CY1109717T1 - Παραγωγα 5-πυριδινυλιο-1-αζαδικυκλο[3.2.1]οκτανιο, μεθοδος παρασκευης και η εφαρμογη τους στη θεραπευτικη - Google Patents
Παραγωγα 5-πυριδινυλιο-1-αζαδικυκλο[3.2.1]οκτανιο, μεθοδος παρασκευης και η εφαρμογη τους στη θεραπευτικηInfo
- Publication number
- CY1109717T1 CY1109717T1 CY20101100013T CY101100013T CY1109717T1 CY 1109717 T1 CY1109717 T1 CY 1109717T1 CY 20101100013 T CY20101100013 T CY 20101100013T CY 101100013 T CY101100013 T CY 101100013T CY 1109717 T1 CY1109717 T1 CY 1109717T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyridinylio
- azadicylic
- octane
- therapeutic
- preparation
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η εφεύρεση αφορά τις ενώσεις της γενικής φόρμουλας (I) (I) στην οποία το R αναπαριστά μια ομάδα που επιλέγεται ανάμεσα σε ένα πυραζολύλιο, ιμιδαζολύλιο, τριαζολύλιο, οξαζολύλιο, οξαδιαζολύλιο, θειαζολύλιο, ισοθειαζολύλιο, θειαδιαζολύλιο, τετραζολύλιο, με την ομάδα αυτή να μπορεί τελικά να αντικατασταθεί από μία ή περισσότερες ομάδες που επιλέγονται ανάμεσα στα άτομα αλογόνου, τις ομάδες (C1-C6)αλκύλιο, (C1-C6)αλκοξύ, τριφθορομεθοξύ, τριφθορομεθύλιο, νίτρο, κύανο, υδροξύ, άμινο, (C1-C6)αλκυλάμινο ή δι(C1-C6)αλκυλάμινο, ο δεσμός άνθρακα-άνθρακα ανάμεσα στις θέσεις 3 και 4 του κύκλου αζαδικυκλοοκτάνιο είναι μονός ή διπλός σε κατάσταση βάσης ή άλατος προσθήκης οξέος, όπως και σε κατάσταση υδρικού ή διαλυτή. Διαδικασία για την παρασκευή και εφαρμογή στη θεραπευτική.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0508528A FR2889701B1 (fr) | 2005-08-12 | 2005-08-12 | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
| EP06794298A EP1915375B1 (fr) | 2005-08-12 | 2006-08-07 | DÉRIVÉS DE -PYRIDINYL-i-AZABICYCLO[3.2.1]OCTANE, A LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109717T1 true CY1109717T1 (el) | 2014-08-13 |
Family
ID=36273387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100013T CY1109717T1 (el) | 2005-08-12 | 2010-01-05 | Παραγωγα 5-πυριδινυλιο-1-αζαδικυκλο[3.2.1]οκτανιο, μεθοδος παρασκευης και η εφαρμογη τους στη θεραπευτικη |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US7863290B2 (el) |
| EP (1) | EP1915375B1 (el) |
| JP (1) | JP5164841B2 (el) |
| KR (1) | KR101299339B1 (el) |
| CN (1) | CN101238125B (el) |
| AT (1) | ATE444964T1 (el) |
| AU (1) | AU2006281341B2 (el) |
| BR (1) | BRPI0614623A2 (el) |
| CA (1) | CA2617828C (el) |
| CR (1) | CR9625A (el) |
| CY (1) | CY1109717T1 (el) |
| DE (1) | DE602006009668D1 (el) |
| DK (1) | DK1915375T3 (el) |
| DO (1) | DOP2006000180A (el) |
| EA (1) | EA014023B1 (el) |
| EC (1) | ECSP088170A (el) |
| ES (1) | ES2332472T3 (el) |
| FR (1) | FR2889701B1 (el) |
| GT (1) | GT200600368A (el) |
| HK (1) | HK1120788A1 (el) |
| HN (1) | HN2008000090A (el) |
| HR (1) | HRP20090677T1 (el) |
| IL (1) | IL188796A (el) |
| JO (1) | JO2583B1 (el) |
| MA (1) | MA30200B1 (el) |
| ME (1) | ME01750B (el) |
| MX (1) | MX2008001968A (el) |
| MY (1) | MY147846A (el) |
| NO (1) | NO20081151L (el) |
| NZ (1) | NZ565149A (el) |
| PE (1) | PE20070339A1 (el) |
| PL (1) | PL1915375T3 (el) |
| PT (1) | PT1915375E (el) |
| RS (1) | RS51068B (el) |
| SI (1) | SI1915375T1 (el) |
| TN (1) | TNSN07472A1 (el) |
| TW (1) | TWI324158B (el) |
| UA (1) | UA92917C2 (el) |
| UY (1) | UY29744A1 (el) |
| WO (1) | WO2007020344A1 (el) |
| ZA (1) | ZA200800958B (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2912404B1 (fr) * | 2007-02-09 | 2009-04-10 | Sanofi Aventis Sa | Derives d'azabicycloalkane,leur preparation et leur application en therapeutique. |
| GB0817424D0 (en) | 2008-09-24 | 2008-10-29 | Medivir Ab | Protease inhibitors |
| JP2017114765A (ja) * | 2014-04-25 | 2017-06-29 | 大正製薬株式会社 | トリアゾリルで置換されたヘテロアリール化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817679A (en) * | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
| EP0664293A1 (en) * | 1993-12-24 | 1995-07-26 | Duphar International Research B.V | 2-Phenyl-7-azabicycloheptanes and 6-phenyl-8-azabicyclo |
| IL132437A0 (en) * | 1997-05-30 | 2001-03-19 | Neurosearch As | 8-Azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
-
2005
- 2005-08-12 FR FR0508528A patent/FR2889701B1/fr active Active
-
2006
- 2006-07-08 UA UAA200802988A patent/UA92917C2/uk unknown
- 2006-07-26 JO JO2006252A patent/JO2583B1/en active
- 2006-08-02 DO DO2006000180A patent/DOP2006000180A/es unknown
- 2006-08-07 DK DK06794298.7T patent/DK1915375T3/da active
- 2006-08-07 ME MEP-2009-576A patent/ME01750B/me unknown
- 2006-08-07 DE DE602006009668T patent/DE602006009668D1/de active Active
- 2006-08-07 AU AU2006281341A patent/AU2006281341B2/en not_active Ceased
- 2006-08-07 KR KR1020087003271A patent/KR101299339B1/ko not_active IP Right Cessation
- 2006-08-07 SI SI200630515T patent/SI1915375T1/sl unknown
- 2006-08-07 PL PL06794298T patent/PL1915375T3/pl unknown
- 2006-08-07 ES ES06794298T patent/ES2332472T3/es active Active
- 2006-08-07 WO PCT/FR2006/001912 patent/WO2007020344A1/fr active Application Filing
- 2006-08-07 ZA ZA200800958A patent/ZA200800958B/xx unknown
- 2006-08-07 EP EP06794298A patent/EP1915375B1/fr active Active
- 2006-08-07 JP JP2008525599A patent/JP5164841B2/ja not_active Expired - Fee Related
- 2006-08-07 EA EA200800575A patent/EA014023B1/ru not_active IP Right Cessation
- 2006-08-07 CN CN2006800291833A patent/CN101238125B/zh not_active Expired - Fee Related
- 2006-08-07 MX MX2008001968A patent/MX2008001968A/es active IP Right Grant
- 2006-08-07 RS RSP-2009/0576A patent/RS51068B/sr unknown
- 2006-08-07 NZ NZ565149A patent/NZ565149A/en not_active IP Right Cessation
- 2006-08-07 CA CA2617828A patent/CA2617828C/fr not_active Expired - Fee Related
- 2006-08-07 BR BRPI0614623-6A patent/BRPI0614623A2/pt not_active IP Right Cessation
- 2006-08-07 PT PT06794298T patent/PT1915375E/pt unknown
- 2006-08-07 AT AT06794298T patent/ATE444964T1/de active
- 2006-08-10 GT GT200600368A patent/GT200600368A/es unknown
- 2006-08-10 MY MYPI20063888A patent/MY147846A/en unknown
- 2006-08-10 PE PE2006000974A patent/PE20070339A1/es not_active Application Discontinuation
- 2006-08-11 TW TW095129651A patent/TWI324158B/zh not_active IP Right Cessation
- 2006-08-11 UY UY29744A patent/UY29744A1/es not_active Application Discontinuation
-
2007
- 2007-12-14 TN TNP2007000472A patent/TNSN07472A1/en unknown
- 2007-12-20 CR CR9625A patent/CR9625A/es unknown
-
2008
- 2008-01-15 IL IL188796A patent/IL188796A/en not_active IP Right Cessation
- 2008-01-22 HN HN2008000090A patent/HN2008000090A/es unknown
- 2008-02-11 EC EC2008008170A patent/ECSP088170A/es unknown
- 2008-02-11 US US12/028,999 patent/US7863290B2/en not_active Expired - Fee Related
- 2008-03-04 NO NO20081151A patent/NO20081151L/no not_active Application Discontinuation
- 2008-03-07 MA MA30724A patent/MA30200B1/fr unknown
- 2008-11-11 HK HK08112365.4A patent/HK1120788A1/xx not_active IP Right Cessation
-
2009
- 2009-12-17 HR HR20090677T patent/HRP20090677T1/hr unknown
-
2010
- 2010-01-05 CY CY20101100013T patent/CY1109717T1/el unknown
- 2010-11-29 US US12/955,389 patent/US8541440B2/en not_active Expired - Fee Related
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