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CY1106463T1 - Τοπικη ορμονικη συνθεση με συστημικο αποτελεσμα - Google Patents

Τοπικη ορμονικη συνθεση με συστημικο αποτελεσμα

Info

Publication number
CY1106463T1
CY1106463T1 CY20071100563T CY071100563T CY1106463T1 CY 1106463 T1 CY1106463 T1 CY 1106463T1 CY 20071100563 T CY20071100563 T CY 20071100563T CY 071100563 T CY071100563 T CY 071100563T CY 1106463 T1 CY1106463 T1 CY 1106463T1
Authority
CY
Cyprus
Prior art keywords
agent
systemic effect
active ingredient
hormonal composition
local
Prior art date
Application number
CY20071100563T
Other languages
English (en)
Inventor
Michel Lanquetin
Jacques Paris
Jean-Louis Thomas
Original Assignee
Laboratoire Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex filed Critical Laboratoire Theramex
Publication of CY1106463T1 publication Critical patent/CY1106463T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Η εφεύρεση αναφέρεται στον τομέα της θεραπευτικής χημείας και πιο συγκεκριμένα στην παραγωγή νέων γαληνικών μορφών σχεδιασμένων να εφαρμόζονται επί του δέρματος. Ειδικότερα, αφορά μια τοπική ορμονική σύνθεση με συστημικό αποτέλεσμα για την αποκατάσταση του ελλείμματος προγεστερόνης σε γυναίκες προ της εμμηνόπαυσης και ως ορμονικό υποκατάστατο για τη γυναίκα μετά την εμμηνόπαυση. Η εφεύρεση χαρακτηρίζεται από το ότι περιέχει, ως δραστικό συστατικό, μια γεσταγόνο ουσία παραγόμενη από 19-νορπρογεστερόνη, ένα φορέα για τη συστημική διέλευση του εν λόγω δραστικού συστατικού που επιλέγεται από την ομάδα που αποτελείται από μέσον διαλυτοποίησης, μέσον προαγωγής απορρόφησης, μέσον σχηματισμού υμενίου, μέσον πήξης ή τα μίγματά τους, συνδυαζόμενο ή αναμιγνυόμενη με κατάλληλους φορείς για την παραγωγή μιας πηγμένης ή/και σχηματίζουσας υμένιο φαρμακευτικής μορφής.
CY20071100563T 1998-03-23 2007-04-26 Τοπικη ορμονικη συνθεση με συστημικο αποτελεσμα CY1106463T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9803533A FR2776191B1 (fr) 1998-03-23 1998-03-23 Composition hormonale topique a effet systemique
PCT/FR1999/000680 WO1999048477A1 (fr) 1998-03-23 1999-03-23 Composition hormonale topique a effet systemique

Publications (1)

Publication Number Publication Date
CY1106463T1 true CY1106463T1 (el) 2012-01-25

Family

ID=9524367

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100563T CY1106463T1 (el) 1998-03-23 2007-04-26 Τοπικη ορμονικη συνθεση με συστημικο αποτελεσμα

Country Status (29)

Country Link
US (1) US20080227763A1 (el)
EP (1) EP1066030B1 (el)
JP (1) JP4579411B2 (el)
KR (1) KR100681322B1 (el)
CN (1) CN1161102C (el)
AP (1) AP1343A (el)
AT (1) ATE353626T1 (el)
AU (1) AU754490B2 (el)
BR (1) BR9909027A (el)
CA (1) CA2324904C (el)
CY (1) CY1106463T1 (el)
CZ (1) CZ300484B6 (el)
DE (1) DE69935135T2 (el)
DK (1) DK1066030T3 (el)
ES (1) ES2283106T3 (el)
FR (1) FR2776191B1 (el)
HK (1) HK1038184A1 (el)
HU (1) HU228863B1 (el)
ID (1) ID27988A (el)
IL (1) IL138607A0 (el)
NO (1) NO331222B1 (el)
NZ (1) NZ507201A (el)
OA (1) OA11489A (el)
PL (1) PL204210B1 (el)
PT (1) PT1066030E (el)
RU (1) RU2215520C2 (el)
TR (1) TR200002751T2 (el)
WO (1) WO1999048477A1 (el)
ZA (1) ZA200005785B (el)

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CZ20011739A3 (cs) * 1998-11-20 2001-10-17 Rtp Pharma Inc. Dispergovatelné fosfolipidem stabilizované mikročástice
WO2001030356A1 (fr) * 1999-10-25 2001-05-03 Laboratoire Theramex Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation
DE10008128A1 (de) * 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
KR100452972B1 (ko) * 2000-05-16 2004-10-14 주식회사 삼양사 경피투여용 하이드로젤 조성물
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
ES2283425T3 (es) 2000-08-03 2007-11-01 Antares Pharma Ipl Ag Nueva composicion para la administracion transdermica y/o transmucosa de compuestos activos que asegura niveles terapeutiocos adecuados.
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
FR2814074B1 (fr) * 2000-09-15 2003-03-07 Theramex Nouvelles compositions estro-progestatives topiques a effet systemique
US7803392B2 (en) 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
US7005557B2 (en) * 2001-07-03 2006-02-28 The Procter & Gamble Company Film-forming compositions for protecting skin from body fluids and articles made therefrom
GB0119480D0 (en) * 2001-08-09 2001-10-03 Jagotec Ag Novel compositions
DE10146541A1 (de) * 2001-09-21 2003-04-17 Kade Pharma Fab Gmbh Arzneimittel auf Basis von Gestagenen zur dermalen Anwendung
MXPA06003316A (es) 2003-10-10 2006-06-08 Antares Pharma Ipl Ag Formulacion farmaceutica transdermica para minimizar los residuos en la piel.
US7425340B2 (en) 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
US7772213B2 (en) 2006-07-27 2010-08-10 Nathan Strick Composition for the treatment of inflammatory conditions
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP2782584B1 (en) 2011-11-23 2021-06-09 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP2742932A1 (en) * 2012-12-17 2014-06-18 Laboratorios Ojer Pharma S.L. Gel compositions
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AR100562A1 (es) 2014-05-22 2016-10-12 Therapeuticsmd Inc Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal
MX2016013693A (es) 2014-07-29 2017-10-31 Therapeuticsmd Inc Crema transdermica.
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
WO2020161771A1 (ja) * 2019-02-04 2020-08-13 マルホ株式会社 皮膚用組成物
GB2597637A (en) * 2020-06-02 2022-02-09 Surfachem Ltd Sanitiser composition

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ES2180690T3 (es) * 1990-06-01 2003-02-16 Population Council Inc Preparacion de composiciones que comprenden st1435 para aplicacion topica.
FR2668945B1 (fr) * 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
JPH05148146A (ja) * 1991-06-20 1993-06-15 Terumo Corp 水溶性ゲル外用剤
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
FR2695826B1 (fr) * 1992-09-21 1995-01-06 Theramex Nouvelles compositions pharmaceutiques à base de dérivés de nomégestrol et leurs procédés d'obtention.
DE4309830C1 (de) * 1993-03-26 1994-05-05 Lohmann Therapie Syst Lts Wirkstoffpflaster für die Abgabe von Estradiol an die Haut
IL105600A (en) * 1993-05-04 1999-12-31 Allon Blank Pharmaceutical and cosmetic compositions with increased rate of transdermal penetration and antioxidation protection against degradation containing derivatives of thioglycolic and mercaptopropionic acids some such novel compounds and their use
EP0785211A1 (en) * 1996-01-22 1997-07-23 Laboratoire Theramex New substituted 19-nor-pregnane derivatives
EP0785212A1 (en) * 1996-01-22 1997-07-23 Laboratoire Theramex New 19-nor-pregnene derivatives
JP4346696B2 (ja) * 1996-05-28 2009-10-21 久光製薬株式会社 経皮治療用装置
IT1283102B1 (it) * 1996-06-06 1998-04-07 Permatec Nv Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele

Also Published As

Publication number Publication date
JP2002507561A (ja) 2002-03-12
PL343256A1 (en) 2001-07-30
WO1999048477A1 (fr) 1999-09-30
EP1066030A1 (fr) 2001-01-10
AP2000001948A0 (en) 2000-12-31
FR2776191A1 (fr) 1999-09-24
AU2845199A (en) 1999-10-18
NO20004745D0 (no) 2000-09-22
CZ300484B6 (cs) 2009-05-27
IL138607A0 (en) 2001-10-31
JP4579411B2 (ja) 2010-11-10
KR20010042152A (ko) 2001-05-25
AP1343A (en) 2004-12-15
PT1066030E (pt) 2007-05-31
ID27988A (id) 2001-05-03
NO331222B1 (no) 2011-11-07
RU2215520C2 (ru) 2003-11-10
CN1161102C (zh) 2004-08-11
CA2324904A1 (fr) 1999-09-30
US20080227763A1 (en) 2008-09-18
KR100681322B1 (ko) 2007-02-09
TR200002751T2 (tr) 2000-12-21
ES2283106T3 (es) 2007-10-16
DE69935135D1 (de) 2007-03-29
HUP0101579A3 (en) 2002-01-28
OA11489A (fr) 2004-05-08
EP1066030B1 (fr) 2007-02-14
HUP0101579A2 (hu) 2001-11-28
FR2776191B1 (fr) 2002-05-31
ATE353626T1 (de) 2007-03-15
NZ507201A (en) 2003-07-25
HU228863B1 (en) 2013-06-28
CN1301146A (zh) 2001-06-27
DE69935135T2 (de) 2007-10-31
PL204210B1 (pl) 2009-12-31
NO20004745L (no) 2000-11-20
HK1038184A1 (en) 2002-03-08
ZA200005785B (en) 2001-06-12
CA2324904C (fr) 2009-03-03
CZ20003471A3 (cs) 2001-07-11
BR9909027A (pt) 2001-12-11
AU754490B2 (en) 2002-11-21
DK1066030T3 (da) 2007-06-11

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