[go: up one dir, main page]

DE69935135D1 - Topische hormonhaltige zusammensetzung mit systemischer wirkung - Google Patents

Topische hormonhaltige zusammensetzung mit systemischer wirkung

Info

Publication number
DE69935135D1
DE69935135D1 DE69935135T DE69935135T DE69935135D1 DE 69935135 D1 DE69935135 D1 DE 69935135D1 DE 69935135 T DE69935135 T DE 69935135T DE 69935135 T DE69935135 T DE 69935135T DE 69935135 D1 DE69935135 D1 DE 69935135D1
Authority
DE
Germany
Prior art keywords
hormonic
topical
composition
systemic effect
systemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69935135T
Other languages
English (en)
Other versions
DE69935135T2 (de
Inventor
Michel Lanquetin
Le Clos De Cimiez Paris
Jean-Louis Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Theramex SAM
Original Assignee
Laboratoire Theramex SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Publication of DE69935135D1 publication Critical patent/DE69935135D1/de
Application granted granted Critical
Publication of DE69935135T2 publication Critical patent/DE69935135T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
DE69935135T 1998-03-23 1999-03-23 Topische hormonhaltige zusammensetzung mit systemischer wirkung Expired - Lifetime DE69935135T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9803533A FR2776191B1 (fr) 1998-03-23 1998-03-23 Composition hormonale topique a effet systemique
FR9803533 1998-03-23
PCT/FR1999/000680 WO1999048477A1 (fr) 1998-03-23 1999-03-23 Composition hormonale topique a effet systemique

Publications (2)

Publication Number Publication Date
DE69935135D1 true DE69935135D1 (de) 2007-03-29
DE69935135T2 DE69935135T2 (de) 2007-10-31

Family

ID=9524367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69935135T Expired - Lifetime DE69935135T2 (de) 1998-03-23 1999-03-23 Topische hormonhaltige zusammensetzung mit systemischer wirkung

Country Status (29)

Country Link
US (1) US20080227763A1 (de)
EP (1) EP1066030B1 (de)
JP (1) JP4579411B2 (de)
KR (1) KR100681322B1 (de)
CN (1) CN1161102C (de)
AP (1) AP1343A (de)
AT (1) ATE353626T1 (de)
AU (1) AU754490B2 (de)
BR (1) BR9909027A (de)
CA (1) CA2324904C (de)
CY (1) CY1106463T1 (de)
CZ (1) CZ300484B6 (de)
DE (1) DE69935135T2 (de)
DK (1) DK1066030T3 (de)
ES (1) ES2283106T3 (de)
FR (1) FR2776191B1 (de)
HK (1) HK1038184A1 (de)
HU (1) HU228863B1 (de)
ID (1) ID27988A (de)
IL (1) IL138607A0 (de)
NO (1) NO331222B1 (de)
NZ (1) NZ507201A (de)
OA (1) OA11489A (de)
PL (1) PL204210B1 (de)
PT (1) PT1066030E (de)
RU (1) RU2215520C2 (de)
TR (1) TR200002751T2 (de)
WO (1) WO1999048477A1 (de)
ZA (1) ZA200005785B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20011739A3 (cs) * 1998-11-20 2001-10-17 Rtp Pharma Inc. Dispergovatelné fosfolipidem stabilizované mikročástice
WO2001030356A1 (fr) * 1999-10-25 2001-05-03 Laboratoire Theramex Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation
DE10008128A1 (de) * 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
KR100452972B1 (ko) * 2000-05-16 2004-10-14 주식회사 삼양사 경피투여용 하이드로젤 조성물
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
ATE485837T1 (de) 2000-08-03 2010-11-15 Antares Pharma Ipl Ag Zusammensetzung zur transdermalen und/oder transmukosalen verabreichung von wirkstoffen, die ausreichende therapeutische spiegel garantiert
FR2814074B1 (fr) * 2000-09-15 2003-03-07 Theramex Nouvelles compositions estro-progestatives topiques a effet systemique
US7803392B2 (en) 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
US7005557B2 (en) 2001-07-03 2006-02-28 The Procter & Gamble Company Film-forming compositions for protecting skin from body fluids and articles made therefrom
GB0119480D0 (en) * 2001-08-09 2001-10-03 Jagotec Ag Novel compositions
DE10146541A1 (de) * 2001-09-21 2003-04-17 Kade Pharma Fab Gmbh Arzneimittel auf Basis von Gestagenen zur dermalen Anwendung
PL1670433T3 (pl) 2003-10-10 2013-03-29 Ferring Bv Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze
US7425340B2 (en) 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US8067399B2 (en) 2005-05-27 2011-11-29 Antares Pharma Ipl Ag Method and apparatus for transdermal or transmucosal application of testosterone
US7772213B2 (en) 2006-07-27 2010-08-10 Nathan Strick Composition for the treatment of inflammatory conditions
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
EP2742932A1 (de) * 2012-12-17 2014-06-18 Laboratorios Ojer Pharma S.L. Gelzusammensetzungen
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
AU2015296609A1 (en) * 2014-07-29 2016-12-22 Therapeuticsmd, Inc. Transdermal cream
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
BR112018070199A2 (pt) 2016-04-01 2019-01-29 Therapeuticsmd Inc composição farmacêutica de hormônio esteroide
WO2020161771A1 (ja) * 2019-02-04 2020-08-13 マルホ株式会社 皮膚用組成物
GB2597637A (en) * 2020-06-02 2022-02-09 Surfachem Ltd Sanitiser composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE220912T1 (de) * 1990-06-01 2002-08-15 Population Council Inc Herstellung von st1435 enthaltenden pharmazeutischen zusammensetzungen zur topischen verwendung
FR2668945B1 (fr) * 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
JPH05148146A (ja) * 1991-06-20 1993-06-15 Terumo Corp 水溶性ゲル外用剤
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
FR2695826B1 (fr) * 1992-09-21 1995-01-06 Theramex Nouvelles compositions pharmaceutiques à base de dérivés de nomégestrol et leurs procédés d'obtention.
DE4309830C1 (de) * 1993-03-26 1994-05-05 Lohmann Therapie Syst Lts Wirkstoffpflaster für die Abgabe von Estradiol an die Haut
IL105600A (en) * 1993-05-04 1999-12-31 Allon Blank Pharmaceutical and cosmetic compositions with increased rate of transdermal penetration and antioxidation protection against degradation containing derivatives of thioglycolic and mercaptopropionic acids some such novel compounds and their use
EP0785212A1 (de) * 1996-01-22 1997-07-23 Laboratoire Theramex Neue 19-nor-Pregnan-Derivate
EP0785211A1 (de) * 1996-01-22 1997-07-23 Laboratoire Theramex Neue substituierte 19-nor-Pregnan-Derivate
JP4346696B2 (ja) * 1996-05-28 2009-10-21 久光製薬株式会社 経皮治療用装置
IT1283102B1 (it) * 1996-06-06 1998-04-07 Permatec Nv Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele

Also Published As

Publication number Publication date
CN1161102C (zh) 2004-08-11
NO331222B1 (no) 2011-11-07
ATE353626T1 (de) 2007-03-15
AP1343A (en) 2004-12-15
EP1066030B1 (de) 2007-02-14
FR2776191B1 (fr) 2002-05-31
NO20004745D0 (no) 2000-09-22
BR9909027A (pt) 2001-12-11
CA2324904C (fr) 2009-03-03
US20080227763A1 (en) 2008-09-18
HK1038184A1 (en) 2002-03-08
PT1066030E (pt) 2007-05-31
CN1301146A (zh) 2001-06-27
JP2002507561A (ja) 2002-03-12
PL343256A1 (en) 2001-07-30
OA11489A (fr) 2004-05-08
CA2324904A1 (fr) 1999-09-30
HUP0101579A3 (en) 2002-01-28
DK1066030T3 (da) 2007-06-11
KR100681322B1 (ko) 2007-02-09
WO1999048477A1 (fr) 1999-09-30
RU2215520C2 (ru) 2003-11-10
ZA200005785B (en) 2001-06-12
NZ507201A (en) 2003-07-25
FR2776191A1 (fr) 1999-09-24
AP2000001948A0 (en) 2000-12-31
AU2845199A (en) 1999-10-18
KR20010042152A (ko) 2001-05-25
TR200002751T2 (tr) 2000-12-21
DE69935135T2 (de) 2007-10-31
HU228863B1 (en) 2013-06-28
NO20004745L (no) 2000-11-20
ID27988A (id) 2001-05-03
IL138607A0 (en) 2001-10-31
CZ20003471A3 (cs) 2001-07-11
EP1066030A1 (de) 2001-01-10
PL204210B1 (pl) 2009-12-31
CY1106463T1 (el) 2012-01-25
CZ300484B6 (cs) 2009-05-27
JP4579411B2 (ja) 2010-11-10
HUP0101579A2 (hu) 2001-11-28
AU754490B2 (en) 2002-11-21
ES2283106T3 (es) 2007-10-16

Similar Documents

Publication Publication Date Title
DE69935135D1 (de) Topische hormonhaltige zusammensetzung mit systemischer wirkung
DE60022162D1 (de) Topische zusammensetzung mit n-acetylglukosamin
DE69934805D1 (de) Substituierte imidazole mit cytokin-inhibierender wirkung
HUP0204349A3 (en) Novel topical oestroprogestational compositions with systemic effect
ID26926A (id) Komposisi shampo pembentuk mode
DE69919156D1 (de) Oxyiminoalkansäure derivate mit hypoglykämischer und hypolipidemischer wirkung
ID26186A (id) Komposisi sampo
ID28694A (id) Komposisi sampo
ID29430A (id) Komposisi herbisida
DE69926237D1 (de) Beschichtungszusammensetzung
DE69816216D1 (de) Reversible Thermochrome Zusammensetzung
BR9915458B1 (pt) formulação antiparasitária tópica.
ID27776A (id) Bahan dengan efek antidepresan
DE59708160D1 (de) 1-Dimethylaminomethyl-2-phenyl-cycloalk-2-enverbindungen mit analgetischer Wirkung
ID26370A (id) Komposisi pengkondisian rambut
DE69942892D1 (de) Gaserzeugende zusammensetzung
DE69928862D1 (de) Zusammensetzung
DE69919480D1 (de) Beschichtungszusammensetzung
DE69930277D1 (de) Haarformungszusammensetzung
FR2748659B1 (fr) Composition topique amincissante
ATE269106T1 (de) Glycolipid-cremes
NO20011983D0 (no) Beleggsammensetning
FI103827B1 (fi) Levitystela
ID26295A (id) Komposisi keras-ultraviolet
ID26485A (id) Komposisi paroksetina

Legal Events

Date Code Title Description
8364 No opposition during term of opposition