CS253740B2 - Process for preparing 4,4-dialkyl-2-azetidinones - Google Patents

Process for preparing 4,4-dialkyl-2-azetidinones Download PDF

Info

Publication number: CS253740B2
Authority: CS; Czechoslovakia
Prior art keywords: group; formula; tert; compound; benzyl
Prior art date: 1985-01-28

Application number

CS86625A

Other languages

Czech (cs)

English (en)

Inventor

William A Slusarchyk

Tamara Dejneka

William H Koster

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-28

Filing date

1986-01-28

Publication date

1987-12-17

1986-01-28 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1986-06-03 Priority to CS864065A priority Critical patent/CS253749B2/cs

1987-12-17 Publication of CS253740B2 publication Critical patent/CS253740B2/cs

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/18—Salts thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyridine Compounds (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CS86625A 1985-01-28 1986-01-28 Process for preparing 4,4-dialkyl-2-azetidinones CS253740B2 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CS864065A CS253749B2 (cs)	1985-01-28	1986-06-03	Způsob výroby 3-substituovaných 2-oxo-4,4-dimethyl-1-azetidinylsulfátů

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/695,775 US4638061A (en)	1985-01-28	1985-01-28	[3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy] acetic acid and intermediate

Publications (1)

Publication Number	Publication Date
CS253740B2 true CS253740B2 (en)	1987-12-17

Family

ID=24794413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS86625A CS253740B2 (en)	1985-01-28	1986-01-28	Process for preparing 4,4-dialkyl-2-azetidinones

Country Status (35)

Country	Link
US (1)	US4638061A (es)
JP (2)	JPH0780840B2 (es)
KR (1)	KR900000675B1 (es)
CN (1)	CN1014894B (es)
AR (1)	AR242024A1 (es)
AT (1)	AT389511B (es)
AU (1)	AU588017B2 (es)
BE (1)	BE904121A (es)
CA (2)	CA1283924C (es)
CH (3)	CH670825A5 (es)
CS (1)	CS253740B2 (es)
DD (3)	DD248592A5 (es)
DE (1)	DE3602347A1 (es)
DK (1)	DK39486A (es)
EG (1)	EG17682A (es)
ES (3)	ES8706112A1 (es)
FI (1)	FI85022C (es)
FR (1)	FR2576596B1 (es)
GB (2)	GB2170201B (es)
GR (1)	GR860239B (es)
HU (1)	HU196367B (es)
IE (2)	IE59629B1 (es)
IL (1)	IL77661A (es)
IT (1)	IT1190604B (es)
LU (1)	LU86262A1 (es)
NL (1)	NL8600136A (es)
NO (1)	NO170014C (es)
NZ (1)	NZ214836A (es)
PH (3)	PH22425A (es)
PL (3)	PL257668A1 (es)
PT (1)	PT81914B (es)
RO (1)	RO93483B (es)
SE (3)	SE467824B (es)
YU (2)	YU45760B (es)
ZA (1)	ZA86302B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4751220A (en) *	1986-12-19	1988-06-14	E. R. Squibb & Sons, Inc.	Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid
US5143913A (en) *	1988-04-04	1992-09-01	E. R. Squibb & Sons, Inc.	[3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
EP0336667A3 (en) *	1988-04-04	1991-04-10	E.R. Squibb & Sons, Inc.	[3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]-amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
US4973747A (en) *	1989-08-15	1990-11-27	E. R. Squibb & Sons, Inc.	Process for preparing 3-hydroxy 2-keto acids
US8901293B2 (en) *	2005-12-07	2014-12-02	Basilea Pharmaceutica Ag	Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
WO2017180794A1 (en)	2016-04-13	2017-10-19	Skyline Antiinfectives, Inc.	Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4337197A (en) *	1980-10-31	1982-06-29	E. R. Squibb & Sons, Inc.	O-sulfated β-lactam hydroxamic acids and intermediates
JPS58113174A (ja) *	1981-12-26	1983-07-05	Toyama Chem Co Ltd	新規なアゼチジン誘導体またはその塩類を含有する抗菌剤
JPS58194856A (ja) *	1982-05-10	1983-11-12	Yamanouchi Pharmaceut Co Ltd	新規２−アゼチジノン誘導体
JPS58206589A (ja) *	1982-05-26	1983-12-01	Yamanouchi Pharmaceut Co Ltd	２−アゼチジノン誘導体
US4565654A (en) *	1983-03-28	1986-01-21	University Of Notre Dame Du Lac	N-Acyloxy monocyclic β-lactams

1985
- 1985-01-28 US US06/695,775 patent/US4638061A/en not_active Expired - Fee Related
1986
- 1986-01-15 GB GB08600825A patent/GB2170201B/en not_active Expired
- 1986-01-15 ZA ZA86302A patent/ZA86302B/xx unknown
- 1986-01-15 NZ NZ214836A patent/NZ214836A/xx unknown
- 1986-01-15 CA CA000499611A patent/CA1283924C/en not_active Expired - Lifetime
- 1986-01-16 PH PH33290A patent/PH22425A/en unknown
- 1986-01-16 YU YU5886A patent/YU45760B/sh unknown
- 1986-01-17 AU AU52460/86A patent/AU588017B2/en not_active Ceased
- 1986-01-17 FR FR868600631A patent/FR2576596B1/fr not_active Expired
- 1986-01-20 FI FI860247A patent/FI85022C/fi not_active IP Right Cessation
- 1986-01-21 IL IL77661A patent/IL77661A/xx not_active IP Right Cessation
- 1986-01-22 LU LU86262A patent/LU86262A1/fr unknown
- 1986-01-22 NL NL8600136A patent/NL8600136A/xx not_active Application Discontinuation
- 1986-01-24 IE IE20586A patent/IE59629B1/en not_active IP Right Cessation
- 1986-01-24 IE IE930750A patent/IE930750L/xx unknown
- 1986-01-26 EG EG35/86A patent/EG17682A/xx active
- 1986-01-27 HU HU86375A patent/HU196367B/hu not_active IP Right Cessation
- 1986-01-27 DE DE19863602347 patent/DE3602347A1/de not_active Ceased
- 1986-01-27 CH CH2358/88A patent/CH670825A5/fr not_active IP Right Cessation
- 1986-01-27 CH CH305/86A patent/CH667872A5/fr not_active IP Right Cessation
- 1986-01-27 ES ES551252A patent/ES8706112A1/es not_active Expired
- 1986-01-27 KR KR1019860000501A patent/KR900000675B1/ko not_active Expired
- 1986-01-27 NO NO860273A patent/NO170014C/no unknown
- 1986-01-27 PT PT81914A patent/PT81914B/pt not_active IP Right Cessation
- 1986-01-27 CH CH2357/88A patent/CH670824A5/fr not_active IP Right Cessation
- 1986-01-27 RO RO122011A patent/RO93483B/ro unknown
- 1986-01-27 SE SE8600355A patent/SE467824B/sv not_active IP Right Cessation
- 1986-01-27 DK DK39486A patent/DK39486A/da not_active Application Discontinuation
- 1986-01-28 CN CN86100736A patent/CN1014894B/zh not_active Expired
- 1986-01-28 AR AR86302968A patent/AR242024A1/es active
- 1986-01-28 BE BE0/216191A patent/BE904121A/fr not_active IP Right Cessation
- 1986-01-28 PL PL25766886A patent/PL257668A1/xx unknown
- 1986-01-28 JP JP61017708A patent/JPH0780840B2/ja not_active Expired - Lifetime
- 1986-01-28 CS CS86625A patent/CS253740B2/cs unknown
- 1986-01-28 DD DD86292942A patent/DD248592A5/de unknown
- 1986-01-28 GR GR860239A patent/GR860239B/el unknown
- 1986-01-28 PL PL1986262318A patent/PL262318A1/xx unknown
- 1986-01-28 AT AT0020386A patent/AT389511B/de not_active IP Right Cessation
- 1986-01-28 IT IT19206/86A patent/IT1190604B/it active
- 1986-01-28 DD DD86286545A patent/DD241600A5/de not_active IP Right Cessation
- 1986-01-28 DD DD86292943A patent/DD248584A5/de unknown
- 1986-01-28 PL PL1986262317A patent/PL149156B1/pl unknown
- 1986-09-09 ES ES557056A patent/ES8800897A1/es not_active Expired
- 1986-09-09 ES ES557057A patent/ES8801917A1/es not_active Expired
1987
- 1987-02-18 PH PH34872A patent/PH23093A/en unknown
- 1987-02-18 PH PH34871A patent/PH23084A/en unknown
- 1987-09-08 YU YU01670/87A patent/YU167087A/xx unknown
1988
- 1988-01-08 GB GB08800425A patent/GB2198133B/en not_active Expired
1989
- 1989-11-24 CA CA000615565A patent/CA1279322C/en not_active Expired - Lifetime
1990
- 1990-07-03 SE SE9002337A patent/SE502442C2/sv not_active IP Right Cessation
- 1990-07-03 SE SE9002338A patent/SE468896B/sv not_active IP Right Cessation
1995
- 1995-02-21 JP JP7032368A patent/JPH0853404A/ja active Pending

Also Published As

Publication number	Publication date
YU45760B (sh)	1992-07-20
KR860005812A (ko)	1986-08-13
AU588017B2 (en)	1989-09-07
GR860239B (en)	1986-05-28
ATA20386A (de)	1989-05-15
YU5886A (en)	1988-02-29
HU196367B (en)	1988-11-28
PH23084A (en)	1989-04-10
LU86262A1 (fr)	1986-08-04
CA1283924C (en)	1991-05-07
FR2576596A1 (fr)	1986-08-01
GB2198133B (en)	1989-01-11
IL77661A (en)	1989-06-30
SE9002338D0 (sv)	1990-07-03
AR242024A1 (es)	1993-02-26
YU167087A (en)	1988-04-30
JPH0780840B2 (ja)	1995-08-30
ES557056A0 (es)	1987-12-01
ES8801917A1 (es)	1988-03-01
DK39486A (da)	1986-07-29
SE467824B (sv)	1992-09-21
NZ214836A (en)	1988-10-28
CA1279322C (en)	1991-01-22
SE8600355L (sv)	1986-07-29
PL262317A1 (en)	1987-09-07
RO93483B (ro)	1988-01-01
CN1014894B (zh)	1991-11-27
US4638061A (en)	1987-01-20
SE9002338L (sv)	1990-07-03
EG17682A (en)	1990-10-30
RO93483A (ro)	1987-12-31
IE860205L (en)	1986-07-28
GB8800425D0 (en)	1988-02-10
IT8619206A0 (it)	1986-01-28
ES557057A0 (es)	1988-03-01
DE3602347A1 (de)	1986-07-31
BE904121A (fr)	1986-05-15
AU5246086A (en)	1986-07-31
CN86100736A (zh)	1986-10-22
FI85022C (fi)	1992-02-25
NO170014C (no)	1992-09-02
AT389511B (de)	1989-12-27
GB2170201B (en)	1989-01-11
CH667872A5 (fr)	1988-11-15
NO860273L (no)	1986-07-29
IT1190604B (it)	1988-02-16
FR2576596B1 (fr)	1989-12-15
ES551252A0 (es)	1987-06-01
ES8800897A1 (es)	1987-12-01
CH670824A5 (es)	1989-07-14
IE59629B1 (en)	1994-03-09
SE9002337D0 (sv)	1990-07-03
IE930750L (en)	1986-07-28
JPS61176563A (ja)	1986-08-08
SE468896B (sv)	1993-04-05
FI860247L (fi)	1986-07-29
PT81914A (en)	1986-02-01
SE502442C2 (sv)	1995-10-16
KR900000675B1 (ko)	1990-02-02
PL257668A1 (en)	1987-03-09
HUT40407A (en)	1986-12-28
DD248584A5 (de)	1987-08-12
ZA86302B (en)	1986-08-27
SE8600355D0 (sv)	1986-01-27
PL262318A1 (en)	1987-09-07
SE9002337L (sv)	1990-07-03
NL8600136A (nl)	1986-08-18
PH22425A (en)	1988-09-12
CH670825A5 (es)	1989-07-14
PH23093A (en)	1989-04-10
GB2198133A (en)	1988-06-08
GB2170201A (en)	1986-07-30
NO170014B (no)	1992-05-25
ES8706112A1 (es)	1987-06-01
FI85022B (fi)	1991-11-15
DD241600A5 (de)	1986-12-17
FI860247A0 (fi)	1986-01-20
DK39486D0 (da)	1986-01-27
PT81914B (pt)	1987-11-30
JPH0853404A (ja)	1996-02-27
DD248592A5 (de)	1987-08-12
PL149156B1 (en)	1990-01-31

Publication	Publication Date	Title
DE69433715T2 (de)	2005-03-24	Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen
CS253740B2 (en)	1987-12-17	Process for preparing 4,4-dialkyl-2-azetidinones
US5831086A (en)	1998-11-03	Production of cefotaxime and new sodium salts
DE69918050T2 (de)	2005-06-30	Verfahren zur herstellung von (2r,3s)-3-amino-1,2-oxiran
CS271476B2 (en)	1990-10-12	Method of pyrimidine's new derivatives production
US5250525A (en)	1993-10-05	4-oxo-azetidine-2-sulfonic acids and their salts, processes for the preparation thereof and their use
EP3807268B1 (en)	2024-01-24	Process for the preparation of lifitegrast
US5322963A (en)	1994-06-21	Method for preparing α-amino-β, δ-diol derivatives
HRP980175A2 (en)	1999-06-30	Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
SU803859A3 (ru)	1981-02-07	Способ получени -тиопропионами-дОВ или иХ КиСлОТНО-АддиТиВНыХСОлЕй
US6407258B1 (en)	2002-06-18	Method for producing S-alkyl(aryl)-substituted imidazol derivatives
WO2001074795A1 (fr)	2001-10-11	Procede de fabrication d'esters d'acide amique
IE870824L (en)	1987-10-16	N-(sulfonylmethyl) formamides.
KR890001851B1 (ko)	1989-05-27	아미노알칸올에스테르의 신규 제조방법
JPH0219356A (ja)	1990-01-23	アミノアセトニトリル誘導体及びその製造方法
FR2520745A1 (fr)	1983-08-05	Nouvelles 23-o-carbamoyl substitue-23-demycinosyldesmycosines utiles comme medicaments antibacteriens
KR870001793B1 (ko)	1987-10-12	N-설파모일-3-(2-구아니디노티아졸-4-일메틸티오)프로피온아미딘 유도체의 제조방법
Isoda et al.	2006	An efficient method for the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine useful for the pendant moiety of oral carbapenem, L-084
KR100404965B1 (ko)	2003-11-10	조합화학(combinatorial chemistry)에서 특징적으로 고체상과 고리화반응 단계에 트리에틸아민과 ＴＨＦ를 이용하여 신규 히덴토인 유도체의 합성법
KR970004048B1 (ko)	1997-03-24	비대칭형 3-메톡시메틸 세팔로스포린 유도체의 디아스테레오머의 분리방법
RU2083560C1 (ru)	1997-07-10	Способ получения индивидуальных стереоизомеров 4-замещенных тиопроизводных глутаминовой кислоты
SU578007A3 (ru)	1977-10-25	Способ получени производных просцилларидина
MXPA02007077A (es)	2003-03-27	Metodo para la preparacion enantioselectiva de acido 3,3-difenil-2,3-epoxipropionico.
JPH02172967A (ja)	1990-07-04	炭酸エステルの製造方法
JPH08198837A (ja)	1996-08-06	２−アミノ−１−アルカノール誘導体の製造方法