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CO6420359A2 - Anticuerpo anti-lectina similar a inmuglobulina de unión a ácido siálico-15 - Google Patents

Anticuerpo anti-lectina similar a inmuglobulina de unión a ácido siálico-15

Info

Publication number
CO6420359A2
CO6420359A2 CO11085127A CO11085127A CO6420359A2 CO 6420359 A2 CO6420359 A2 CO 6420359A2 CO 11085127 A CO11085127 A CO 11085127A CO 11085127 A CO11085127 A CO 11085127A CO 6420359 A2 CO6420359 A2 CO 6420359A2
Authority
CO
Colombia
Prior art keywords
immuglobulin
union
lectin antibody
antibody
syalic
Prior art date
Application number
CO11085127A
Other languages
English (en)
Inventor
Yoshiharu Hiruma
Eisuke Tsuda
Takashi Takizawa
Makiko Nakayama
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CO6420359A2 publication Critical patent/CO6420359A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se provee una composición farmacéutica para tratar y/o prevenir el metabolismo anormal de hueso que dirige una proteína codificada por un gen fuertemente expresado en osteoclastos; de manera específica, se prevé una composición farmacéutica que contiene un anticuerpo que reconoce específicamente Siglec-15 humana y tiene una actividad de inhibir la formación de osteoclastos, y similares.
CO11085127A 2009-04-09 2011-07-08 Anticuerpo anti-lectina similar a inmuglobulina de unión a ácido siálico-15 CO6420359A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009094613 2009-04-09

Publications (1)

Publication Number Publication Date
CO6420359A2 true CO6420359A2 (es) 2012-04-16

Family

ID=42936292

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11085127A CO6420359A2 (es) 2009-04-09 2011-07-08 Anticuerpo anti-lectina similar a inmuglobulina de unión a ácido siálico-15

Country Status (19)

Country Link
US (3) US8575316B2 (es)
EP (2) EP2377932B1 (es)
JP (2) JP5653909B2 (es)
KR (1) KR101690340B1 (es)
CN (2) CN102272306B (es)
AU (2) AU2010235453B2 (es)
BR (1) BRPI1006134A2 (es)
CA (1) CA2750836C (es)
CO (1) CO6420359A2 (es)
ES (1) ES2840923T3 (es)
IL (2) IL213943A (es)
MX (2) MX2011007342A (es)
MY (1) MY152033A (es)
NZ (2) NZ593550A (es)
RU (2) RU2539790C2 (es)
SG (2) SG172419A1 (es)
TW (1) TWI468177B (es)
WO (1) WO2010117011A1 (es)
ZA (1) ZA201104545B (es)

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IL213943A (en) 2017-06-29
MY152033A (en) 2014-08-15
EP2377932A1 (en) 2011-10-19
RU2539790C2 (ru) 2015-01-27
JP6210966B2 (ja) 2017-10-11
BRPI1006134A2 (pt) 2016-02-23
IL252561B (en) 2019-02-28
MX343049B (es) 2016-10-21
MX2011007342A (es) 2011-07-21
US8575316B2 (en) 2013-11-05
SG172419A1 (en) 2011-07-28
CA2750836C (en) 2018-05-01
NZ605450A (en) 2014-07-25
CN106317224A (zh) 2017-01-11
EP2377932A4 (en) 2013-04-24
US9751944B2 (en) 2017-09-05
AU2010235453B2 (en) 2013-10-03
ZA201104545B (en) 2012-03-28
RU2014147188A (ru) 2016-06-10
JP2015096510A (ja) 2015-05-21
TWI468177B (zh) 2015-01-11
CN102272306A (zh) 2011-12-07
EP3699277A1 (en) 2020-08-26
AU2010235453A1 (en) 2011-07-28
RU2011128332A (ru) 2013-01-20
US20150299318A1 (en) 2015-10-22
TW201039852A (en) 2010-11-16
KR101690340B1 (ko) 2016-12-27
CA2750836A1 (en) 2010-10-14
IL213943A0 (en) 2011-07-31
ES2840923T3 (es) 2021-07-07
SG10201401331TA (en) 2014-10-30
US20110268733A1 (en) 2011-11-03
CN106317224B (zh) 2020-05-12
CN102272306B (zh) 2017-12-26
KR20120034587A (ko) 2012-04-12
US20140065146A1 (en) 2014-03-06
AU2013207589B2 (en) 2016-04-07
WO2010117011A1 (ja) 2010-10-14
JPWO2010117011A1 (ja) 2012-10-18
NZ593550A (en) 2013-11-29
RU2014147188A3 (es) 2018-06-27
JP5653909B2 (ja) 2015-01-14
EP2377932B1 (en) 2020-11-18
US9079959B2 (en) 2015-07-14
IL252561A0 (en) 2017-07-31

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