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CO5690640A2 - Derivados espirociclicos heterociclicos y procedimientos para su uso - Google Patents

Derivados espirociclicos heterociclicos y procedimientos para su uso

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Publication number
CO5690640A2
CO5690640A2 CO06037980A CO06037980A CO5690640A2 CO 5690640 A2 CO5690640 A2 CO 5690640A2 CO 06037980 A CO06037980 A CO 06037980A CO 06037980 A CO06037980 A CO 06037980A CO 5690640 A2 CO5690640 A2 CO 5690640A2
Authority
CO
Colombia
Prior art keywords
alkyl
aryl
atoms
independently
spirociclic
Prior art date
Application number
CO06037980A
Other languages
English (en)
Inventor
Roland E Dollen
Bourdonnec Bertrand Le
Christyopher W Ajello
Minghua Gu
Guo-Hua Chu
Paul Anson Tuthill
Lara K Leister
Jean Q Zhou
Original Assignee
Adolor Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adolor Corp filed Critical Adolor Corp
Publication of CO5690640A2 publication Critical patent/CO5690640A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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Abstract

1.- Un compuesto de fórmula I: en la que:R1 y R3 son cada uno independientemente H, alquilo, alquenilo, alquinilo, o arilo, o R1 y R3 cuando se toman junto con los átomos a través de los cuales están conectados, forman un anillo heterocicloalquilo de 4 a 8 miembros;R2 es H, alquilo, alquenilo, alquinilo, cicloalquilo, alquilcicloalquilo, aralquilo, o heteroarilalquilo, o R1 y R2 cuando se toman junto con los átomos a través de los cuales están conectados, forman un anillo heterocicloalquilo de 4 a 8 miembros, o R2 y R3 cuando se toman junto con los átomos a través de los cuales están conectados, forman un anillo heterocicloalquilo de 4 a 8 miembros;con la condición de que R2 no sea cada Ra es independientemente H o alquilo;cada Rb es independientemente H, alquilo, o arilo;n es el número entero 0, 1, 2 ó 3;A y B son cada uno independientemente H, flúor, o alquilo, o juntos forman un doble enlace entre los átomos de carbono a los cuales están unidos;R4 es -Y-W;Y es un enlace sencillo, C(Ra)(Rb), C(Ra)(Rb)C(Ra)(Rb), o C(Ra)(Rb)C(Ra)(Rb)C(Ra)(Rb);W es arilo o heteroarilo;X es -CH2-, -O-, -S-, -SO, -SO2, o -N(R5)-;R5 es H, alquilo, cicloalquilo, -(CH2)-alquenilo, -(CH2)-alquinilo, arilo, -CORb, o -SO2Rb; y ...
CO06037980A 2003-10-01 2006-04-21 Derivados espirociclicos heterociclicos y procedimientos para su uso CO5690640A2 (es)

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US (6) US7338962B2 (es)
EP (1) EP1675847B1 (es)
JP (2) JP4976134B2 (es)
KR (2) KR20140015122A (es)
CN (2) CN101921279A (es)
AU (1) AU2004278414B2 (es)
BR (1) BRPI0415165A (es)
CA (1) CA2541014A1 (es)
CO (1) CO5690640A2 (es)
IL (2) IL174702A (es)
NZ (3) NZ546834A (es)
WO (1) WO2005033073A2 (es)
ZA (1) ZA200603414B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319939B1 (en) * 1997-12-11 2001-11-20 Janssen Pharmaceutica N.V. Retinoic acid mimetic anlides
JP4976134B2 (ja) * 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
AU2006284860A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers
SI1937669T1 (sl) 2005-09-01 2012-05-31 Janssen Pharmaceutica Nv Novi derivati benzopirana kot odpiralci kalijevega kanala
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
WO2007128782A1 (en) * 2006-05-05 2007-11-15 Boehringer Ingelheim International Gmbh Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes
CN101534819A (zh) * 2006-09-12 2009-09-16 阿得罗公司 含氮的螺环化合物用于增强认知功能的应用
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
JP5524082B2 (ja) * 2008-01-30 2014-06-18 セファロン、インク． ヒスタミン−３（ｈ３）受容体リガンドとしての置換スピロ環状ピペリジン誘導体
CA2712897A1 (en) * 2008-01-30 2009-08-06 Pharmacopeia, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
CA2946445C (en) 2008-05-20 2019-01-08 Acorda Therapeutics, Inc. Hepatoprotectant acetaminophen mutual prodrugs
ES2573497T3 (es) 2011-02-02 2016-06-08 Vertex Pharmaceuticals Incorporated Pirrolopirazin-amidas de piperidina espirocíclicas como moduladores de canales iónicos
CA2827311A1 (en) 2011-02-18 2012-08-23 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
WO2012125613A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
RS56111B1 (sr) * 2011-03-23 2017-10-31 Trevena Inc Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme
SG11201501130PA (en) 2012-08-16 2015-04-29 Janssen Pharmaceutica Nv Substituted pyrazoles as n-type calcium channel blockers
EP2888593B1 (en) 2012-08-21 2018-09-19 Janssen Pharmaceutica NV Antibodies to risperidone and use thereof
EP2888277A4 (en) 2012-08-21 2016-05-18 Ortho Clinical Diagnostics Inc ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF
PL2888284T3 (pl) 2012-08-21 2023-02-27 Janssen Pharmaceutica Nv Przeciwciała przeciwko haptenom rysperydonu i ich zastosowanie
CN110054694B (zh) 2012-08-21 2024-02-20 詹森药业有限公司 阿立哌唑半抗原的抗体及其用途
CN104736564B (zh) 2012-08-21 2019-02-05 詹森药业有限公司 喹硫平半抗原的抗体及其用途
JP6216926B2 (ja) 2012-08-21 2017-10-25 ヤンセン ファーマシューティカ エヌ．ベー． オランザピンに対する抗体及びその使用
AU2013306015B2 (en) 2012-08-21 2017-08-10 Saladax Biomedical Inc. Haptens of aripiprazole and their use in immunoassays
WO2014031668A2 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to quetiapine and use thereof
EP2888287A4 (en) 2012-08-21 2016-04-20 Ortho Clinical Diagnostics Inc ANTIBODIES AGAINST PALIPERIDONE HAPTENES AND THEIR USE
US9494607B2 (en) 2012-08-21 2016-11-15 Janssen Pharmaceutica Nv Antibodies to aripiprazole and use thereof
JP6389177B2 (ja) 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ．ベー． オランザピンハプテンに対する抗体及びその使用
EP2931726B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Spirocyclic morphinans and their use
ES2653265T3 (es) 2012-12-28 2018-02-06 Purdue Pharma Lp Morfinanos sustituidos y el uso de éstos
WO2015023289A1 (en) * 2013-08-16 2015-02-19 Janssen Pharmaceutica Nv Substituted imidazoles as n-type calcium channel blockers
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
US9299409B2 (en) * 2013-09-11 2016-03-29 Tadashi Miyakawa Semiconductor storage device
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands
WO2016100823A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
KR20170025848A (ko) 2015-08-31 2017-03-08 한국건설생활환경시험연구원 교류 직결형 엘이디 램프 결합 구조
AU2016372028B2 (en) 2015-12-14 2022-02-17 Trevena, Inc. Methods of treating hyperalgesia
CN108368180B (zh) 2015-12-17 2022-07-26 詹森药业有限公司 喹硫平的抗体及其用途
MA44056A (fr) 2015-12-17 2018-10-24 Janssen Pharmaceutica Nv Anticorps anti-rispéridone et leur utilisation

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
MX170841B (es) 1988-09-26 1993-09-20 Goodyear Tire & Rubber Proceso mejorado para la sintesis catalizada de metacrilaminadas y acrilimidas n-substituidas
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
ATE120459T1 (de) 1988-12-13 1995-04-15 Beecham Group Plc Benzopyran und verwandte verbindungen.
DE69015886T2 (de) * 1989-06-05 1995-08-03 Tokuyama Corp Fotochromische Verbindung, deren Zusammensetzung und Verwendung.
JPH03173882A (ja) 1989-09-29 1991-07-29 Tanabe Seiyaku Co Ltd クロメン又はチオクロメン誘導体、その製法及びその合成中間体
JP2985322B2 (ja) 1991-03-01 1999-11-29 東レ株式会社 イソキノリン誘導体およびその医薬用途
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
GB9203596D0 (en) 1992-02-20 1992-04-08 Smithkline Beecham Plc Novel process
GB9207400D0 (en) 1992-04-02 1992-05-13 Smithkline Beecham Plc Novel use
CA2100514C (en) 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
ES2064228B1 (es) * 1992-10-19 1995-09-01 Uriach & Cia Sa J Nuevas tetralonas con actividad farmacologica, composiciones que las contienen y procedimiento para su preparacion.
DE69412067T2 (de) * 1993-01-28 1999-03-25 Merck & Co., Inc., Rahway, N.J. Substituierte spiro-azaringen als tachykinine rezeptor antagonisten
US6031115A (en) * 1993-05-14 2000-02-29 Smithkline Beecham Plc Process for preparing epoxides
JPH09505030A (ja) 1993-08-06 1997-05-20 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ ヒドロイソキノリン誘導体
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
AU691296B2 (en) * 1994-05-06 1998-05-14 Pharmacopeia Drug Discovery, Inc. Combinatorial dihydrobenzopyran library
SE9401727D0 (sv) 1994-05-18 1994-05-18 Astra Ab New compounds I
US5683628A (en) 1994-10-17 1997-11-04 Seiko Epson Corp. Photochromic composition and photochromic resin obtainable by using the same
US5628935A (en) * 1994-10-28 1997-05-13 Vision-Ease Lens, Inc. Photochromic spironaphthopyran compounds
WO1996022276A1 (fr) 1995-01-20 1996-07-25 Nippon Shinyaku Co., Ltd. Derives d'ethylamine et medicaments
US5656420A (en) * 1995-02-24 1997-08-12 University Of Kentucky Research Foundation Method for employing the delta opioid dadle to extend tissue survival time during ischemia
IT1307327B1 (it) 1995-09-12 2001-10-30 Smithkline Beecham Spa Derivati idroisochinolinici sostituiti
JPH09301973A (ja) 1996-05-09 1997-11-25 Kumiai Chem Ind Co Ltd クロメン誘導体及びこれを有効成分とする除草剤
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
DE19805370A1 (de) * 1997-03-14 1998-09-17 Gruenenthal Gmbh Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
US6103722A (en) 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
US6319939B1 (en) * 1997-12-11 2001-11-20 Janssen Pharmaceutica N.V. Retinoic acid mimetic anlides
GB9804734D0 (en) 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6436959B1 (en) * 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
FR2787789B1 (fr) 1998-12-29 2002-06-14 Lipha Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
JP2005231995A (ja) 1999-12-22 2005-09-02 Meiji Seika Kaisha Ltd オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物
JP4275288B2 (ja) 2000-03-31 2009-06-10 新明和工業株式会社 ダンプ車輌の油圧制御装置
KR20020093966A (ko) * 2000-04-27 2002-12-16 바실리어 파마슈티카 아게 항균제로서의 크로메닐메틸 피리미딘디아민
US20010036949A1 (en) 2000-05-09 2001-11-01 Coe Jotham Wadsworth Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal
GB0011426D0 (en) 2000-05-11 2000-06-28 Charteris Limited A method for transforming documents written in different XML-based languages
KR20020012346A (ko) 2000-08-07 2002-02-16 유현식 신디오탁틱 폴리스티렌을 고수율로 제조하고 반응기부착물을 감소시키는 담지촉매
AU2002234010A1 (en) 2000-12-14 2002-06-24 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
SE0101773D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101768D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101767D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
PT1395567E (pt) 2001-05-18 2009-03-26 Astrazeneca Ab Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais
SE0101766D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101765D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
EP1279666A1 (en) * 2001-07-24 2003-01-29 Pfizer Products Inc. 1-diphenylmethyl-pyrazole derivatives as opioid receptor ligands
SE0103313D0 (sv) 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
WO2003033486A1 (en) 2001-10-15 2003-04-24 Janssen Pharmaceutica N.V. Novel substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
MXPA04004059A (es) 2001-10-29 2005-03-31 Ardent Pharmaceuticals Inc Metodo para tratar la depresion con compuestos agonistas receptores delta.
US6715527B2 (en) * 2001-12-11 2004-04-06 Raymond V. Ardoin Ventilation apparatus for garages
EP1469850B1 (en) 2002-01-02 2013-01-02 Versi Group, LLC Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
JP2006502190A (ja) 2002-09-18 2006-01-19 ザ キュレイターズ オブ ザ ユニバーシティー オブ ミズーリ デルタ−オピオイド受容体に選択的なオピエート類似物
US20040082612A1 (en) 2002-10-15 2004-04-29 Baxter Ellen W Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives
ATE387443T1 (de) 2002-10-15 2008-03-15 Janssen Pharmaceutica Nv Substituierte aminochinuclidin verbindungen und deren verwendung als delta-opioid rezeptor liganden
SE0203301D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7314880B2 (en) 2003-01-02 2008-01-01 Mount Cook Biosciences, Inc. Cardioprotective delta opioid receptor agonists and methods of using same
SE0300103D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300105D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv) 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
WO2005019157A1 (en) 2003-08-15 2005-03-03 Patel Hasmukh B Choline esters useful for the treatment of cognitive dysfunctions and enhancement of memory, learning and cognition
JP4976134B2 (ja) * 2003-10-01 2012-07-18 アドラー コーポレーション スピロ環複素環誘導体及びそれらを使用する方法
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN101534819A (zh) * 2006-09-12 2009-09-16 阿得罗公司 含氮的螺环化合物用于增强认知功能的应用

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