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CO5540379A2 - Capsulas para inhalacion - Google Patents

Capsulas para inhalacion

Info

Publication number
CO5540379A2
CO5540379A2 CO03108303A CO03108303A CO5540379A2 CO 5540379 A2 CO5540379 A2 CO 5540379A2 CO 03108303 A CO03108303 A CO 03108303A CO 03108303 A CO03108303 A CO 03108303A CO 5540379 A2 CO5540379 A2 CO 5540379A2
Authority
CO
Colombia
Prior art keywords
capsules
inhalation
cellulose
gelatin
peg
Prior art date
Application number
CO03108303A
Other languages
English (en)
Inventor
Karoline Bechthold-Pe
Dieter Hochrainer
Michael Trunk
Michael Walz
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7687020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5540379(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5540379A2 publication Critical patent/CO5540379A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Cápsulas para inhalación, que como polvo inhalable contienen tiotropio en mezcla con una sustancia auxiliar fisiológicamente inocua, caracterizadas porque el material de las cápsulas presenta un contenido reducido de humedad (humedad TEWS de secador con halógeno de menos que 15 % ).2.- Cápsulas para inhalación según la reivindicación 1, caracterizadas porque el material de las cápsulas se selecciona entre el grupo que consta de gelatina, derivados de celulosa, almidón, derivados de almidón, quitosana y materiales plásticos sintéticos.3.- Cápsulas para inhalación según la reivindicación 2, caracterizadas porque como material de las cápsulas se utiliza una gelatina en mezcla con otros aditivos seleccionados entre el grupo que consta de polietilen-glicol (PEG), con preferencia PEG 3350, glicerol, sorbitol, propilen-glicol, copolímeros de bloques PEO-PPO, y otros polialcoholes y poliéteres.4.- Cápsulas para inhalación según la reivindicación 3, caracterizadas porque el material de las cápsulas contiene, además de gelatina, un PEG en una proporción de 1 - 10 % (% en peso), con preferencia de 3 - 8 %.5.- Cápsulas para inhalación según la reivindicación 3 ó 4, caracterizadas porque el material de las cápsulas presenta una humedad TEWS o de secador con halógeno de menos que 12 %, de modo especialmente preferido de = 10 %.6.- Cápsulas para inhalación según la reivindicación 2, caracterizadas porque el material de las cápsulas se selecciona entre el grupo de los derivados de celulosa hidroxipropil-metil-celulosa, hidroxipropil-celulosa, metil-celulosa, hidroximetil-celulosa e hidroxietil-celulosa.
CO03108303A 2001-06-01 2003-12-10 Capsulas para inhalacion CO5540379A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10126924A DE10126924A1 (de) 2001-06-01 2001-06-01 Inhalationskapseln

Publications (1)

Publication Number Publication Date
CO5540379A2 true CO5540379A2 (es) 2005-07-29

Family

ID=7687020

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03108303A CO5540379A2 (es) 2001-06-01 2003-12-10 Capsulas para inhalacion

Country Status (37)

Country Link
EP (2) EP1508330A1 (es)
JP (3) JP4447311B2 (es)
KR (2) KR100952321B1 (es)
CN (3) CN101697965A (es)
AR (2) AR034346A1 (es)
AT (1) ATE285752T1 (es)
AU (2) AU2002344354B2 (es)
BG (1) BG65655B1 (es)
BR (1) BR0209366A (es)
CA (1) CA2448425C (es)
CH (1) CH1379220H1 (es)
CO (1) CO5540379A2 (es)
CZ (1) CZ300284B6 (es)
DE (2) DE10126924A1 (es)
EA (1) EA005188B1 (es)
EC (2) ECSP034868A (es)
EE (1) EE05416B1 (es)
EG (1) EG24227A (es)
ES (1) ES2236590B5 (es)
HR (1) HRP20030993B1 (es)
HU (3) HU231082B1 (es)
IL (2) IL158917A0 (es)
ME (1) ME00301B (es)
MX (1) MXPA03010990A (es)
MY (1) MY126253A (es)
NO (1) NO332857B3 (es)
NZ (1) NZ530356A (es)
PE (1) PE20030071A1 (es)
PL (2) PL203801B1 (es)
PT (1) PT1379220E (es)
RS (1) RS50353B (es)
SI (1) SI1379220T1 (es)
SK (2) SK287379B6 (es)
TW (1) TWI327921B (es)
UA (1) UA75659C2 (es)
WO (1) WO2002098874A2 (es)
ZA (1) ZA200308340B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1292281E (pt) 2000-10-12 2004-11-30 Boehringer Ingelheim Pharma Novos pos para inalacao contendo tiotropio
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
JP2005530765A (ja) * 2002-05-07 2005-10-13 ネクター セラピューティクス 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10255387A1 (de) * 2002-11-28 2004-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Tiotropium-haltige Pulverformulierung für die Inhalation
DE10258360A1 (de) * 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel
DE10352277A1 (de) * 2003-11-08 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
GB0503738D0 (en) 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US7694676B2 (en) 2005-04-22 2010-04-13 Boehringer Ingelheim Gmbh Dry powder inhaler
JP4825455B2 (ja) * 2005-05-02 2011-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 粉末吸入器
DE102006016904A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006016901A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mundstück für einen Inhalator
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
DE102007036411A1 (de) 2007-07-20 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
DE102007052871A1 (de) * 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen
EP2244686A1 (de) * 2008-02-08 2010-11-03 Boehringer Ingelheim International GmbH Verfahren und vorrichtung zur befüllung von kapseln
EP2172190A1 (en) * 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
LT3578169T (lt) 2009-02-26 2024-08-26 Glaxo Group Limited Farmaciniai preparatai, apimantys 4-{(1r)-2-[(6-{2-[(2,6-dichlorbenzil) oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenolį
WO2010110760A1 (en) * 2009-03-27 2010-09-30 Mahmut Bilgic Compositions comprising water with deuterium for the prevention or treatment of allergic diseases and a process for the preparation thereof
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
EP2575786B1 (en) 2010-06-03 2017-11-15 Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. Process for dry powder formulations
DE202011102694U1 (de) 2011-06-29 2011-12-19 Zisser Gmbh Inhalationsgerät für Heimanwender
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US20150150802A1 (en) 2012-07-05 2015-06-04 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscarinic antagonists
DE202013000774U1 (de) 2013-01-21 2013-04-15 Rhinofilt GmbH Miniaturisiertes Inhalationsgerät zur Privatanwendung
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
CN108295042A (zh) * 2018-03-05 2018-07-20 上海祺宇生物科技有限公司 一种用于吸入药剂的植物空心胶囊及其胶囊剂
CN108451920A (zh) * 2018-03-14 2018-08-28 绍兴康可胶囊有限公司 一种吸雾式胶囊及其制备方法
CN114848605B (zh) * 2022-03-25 2023-08-11 上海方予健康医药科技有限公司 一种供吸入粉雾剂用的明胶胶囊

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
ES2159524T3 (es) * 1992-06-12 2001-10-16 Teijin Ltd Preparacion farmaceutica para administrarse en el interior de las vias respiratorias.
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
JP2000143502A (ja) * 1998-11-11 2000-05-23 Shionogi Qualicaps Kk 吸入製剤
ES2192866T3 (es) * 1998-11-13 2003-10-16 Jago Res Ag Polvo seco para inhalacion.
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
EP1072258A1 (de) * 1999-07-28 2001-01-31 Greither, Peter Eine Kapsel für die Freisetzung von Bakterien, enthaltend ein Bakterienlyophilisat und ein Verfahren zu ihrer Herstellung
US7022311B1 (en) * 1999-10-12 2006-04-04 Kaken Pharmaceutical Co., Ltd. Powdery inhalational preparations and process for producing the same
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln

Also Published As

Publication number Publication date
KR20040007638A (ko) 2004-01-24
JP2008050364A (ja) 2008-03-06
DE10126924A1 (de) 2002-12-05
MEP42508A (en) 2011-02-10
NO332857B3 (no) 2016-01-25
PL387118A1 (pl) 2004-12-13
ME00301B (me) 2011-05-10
JP4447311B2 (ja) 2010-04-07
CN101697965A (zh) 2010-04-28
CN1512875A (zh) 2004-07-14
EP1379220B1 (de) 2004-12-29
ES2236590B5 (es) 2018-03-05
PE20030071A1 (es) 2003-03-04
DE50201898D1 (de) 2005-02-03
HUP0400666A2 (hu) 2005-03-29
AU2008203057B2 (en) 2011-12-08
HRP20030993B1 (en) 2011-10-31
PL205714B1 (pl) 2010-05-31
TWI327921B (en) 2010-08-01
CN101829072A (zh) 2010-09-15
CA2448425C (en) 2010-12-21
CH1379220H1 (es) 2018-10-31
AU2008203057C1 (en) 2017-05-18
ZA200308340B (en) 2004-05-21
MXPA03010990A (es) 2004-02-27
RS50353B (sr) 2009-11-10
AU2008203057C8 (en) 2017-04-06
AU2002344354B2 (en) 2008-08-07
NO20035265L (no) 2003-11-27
CA2448425A1 (en) 2002-12-12
CZ20033579A3 (en) 2004-05-12
NO20035265D0 (no) 2003-11-27
EP1379220A2 (de) 2004-01-14
IL158917A0 (en) 2004-05-12
MY126253A (en) 2006-09-29
ECSP11004868A (es) 2011-02-28
SK287379B6 (sk) 2010-08-09
HU231082B1 (hu) 2020-06-29
ECSP034868A (es) 2004-03-23
HUP0400666A3 (en) 2009-06-29
AU2008203057A1 (en) 2008-07-31
WO2002098874A2 (de) 2002-12-12
EA005188B1 (ru) 2004-12-30
UA75659C2 (en) 2006-05-15
HUP1500188A2 (en) 2005-03-29
KR100952321B1 (ko) 2010-04-09
SK16202003A3 (sk) 2004-05-04
PL203801B1 (pl) 2009-11-30
KR20090010140A (ko) 2009-01-28
AR084804A2 (es) 2013-06-26
IL158917A (en) 2008-11-03
SI1379220T1 (en) 2005-04-30
WO2002098874A3 (de) 2003-09-12
NZ530356A (en) 2005-05-27
JP4787034B2 (ja) 2011-10-05
KR100921904B1 (ko) 2009-10-16
PT1379220E (pt) 2005-03-31
SK287346B6 (sk) 2010-07-07
NO332857B1 (no) 2013-01-21
HU230058B1 (hu) 2015-06-29
EA200301275A1 (ru) 2004-06-24
ATE285752T1 (de) 2005-01-15
BG65655B1 (bg) 2009-05-29
EP1508330A1 (de) 2005-02-23
EG24227A (en) 2008-11-10
CZ300284B6 (cs) 2009-04-08
AR034346A1 (es) 2004-02-18
JP2006143747A (ja) 2006-06-08
YU93503A (sh) 2006-05-25
JP2005500279A (ja) 2005-01-06
EE05416B1 (et) 2011-06-15
HRP20030993A2 (en) 2005-08-31
BR0209366A (pt) 2004-06-08
PL364108A1 (en) 2004-12-13
ES2236590T3 (es) 2005-07-16
BG108380A (en) 2004-11-30
EE200300595A (et) 2004-02-16
HU230827B1 (hu) 2018-07-30

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