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CO4910172A1 - Sistema de membrana de afinidad y metodo de uso del mismo - Google Patents

Sistema de membrana de afinidad y metodo de uso del mismo

Info

Publication number
CO4910172A1
CO4910172A1 CO97034165A CO97034165A CO4910172A1 CO 4910172 A1 CO4910172 A1 CO 4910172A1 CO 97034165 A CO97034165 A CO 97034165A CO 97034165 A CO97034165 A CO 97034165A CO 4910172 A1 CO4910172 A1 CO 4910172A1
Authority
CO
Colombia
Prior art keywords
plasma
pores
blood
target molecules
hollow fibers
Prior art date
Application number
CO97034165A
Other languages
English (en)
Inventor
Norma J Ofsthun
Paul J Soltys
Gretchen A Kunas
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of CO4910172A1 publication Critical patent/CO4910172A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/031—Two or more types of hollow fibres within one bundle or within one potting or tube-sheet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • B01D67/00931—Chemical modification by introduction of specific groups after membrane formation, e.g. by grafting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B01J20/28021—Hollow particles, e.g. hollow spheres, microspheres or cenospheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Manufacturing & Machinery (AREA)
  • Water Supply & Treatment (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Nanotechnology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Un dispositivo de membrana de afinidad utilizado para la remociónselectiva de moléculas objetivo contenidas en el plasma de sangre comprende: una caja alargada que tiene una puerta de entrada y una puerta de salida para la entrada y salida de la sangre de ella; fibras huecas encajadas en la cavidad interna, las fibras huecas tienen poros con tamaño de poro adecuados para separar la sangre de plasma y componentes celulares, los poros tienen ligandos inmovilizados a una superficie interna de los poros, los ligandos tienen una afinidad por las moléculas objetivo en el plasma, en donde los componentes celulares de la sangre no fluyen dentro de los poros de las fibras huecas y el plasma es transportado dentro de los poros por medio de filtración positiva e inversa en la ausencia de una bomba externa para generar un flujo de plasma a través de las fibras huecas. 1Un método para la remoción selectiva de moléculas objetivo presentes en el plasma comprende las etapas de: Suministrar un dispositivo de membrana de fibra hueca que tiene (a) una caja alargada con una puerta de entrada única y una puerta de salida única para entrada y salida de la sangre desde ella; y (b) fibras huecas encajadas dentro de la caja, las fibras huecas tienen poros con tamaños de poro adecuados para separar la sangre en plasma y componentes celulares, los poros tienen ligandos ligados a una superficie interna de los poros, los ligandos tienen una afinidad por las moléculas objetivo en el plasma; transportar la sangre dentro de la puerta de entrada de la caja; causar que el plasma de la sangre fluya dentro de los poros de las fibras huecas por medio de filtración positiva e inversa mientras que no le permite que los componentes celulares fluyan dentro de la misma; poner en contacto las moléculas objetivo en el plasma con los ligandos durante un período clínicamente significativo de tiempo para permitir que haya ligación entre las moléculas objetivo a los ligandos; y causar que las moléculas no objetivo del plasma se reúnan con los componentes celulares de la sangre.
CO97034165A 1996-06-20 1997-06-19 Sistema de membrana de afinidad y metodo de uso del mismo CO4910172A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/668,582 US5868936A (en) 1996-06-20 1996-06-20 Affinity membrane system and method of using same

Publications (1)

Publication Number Publication Date
CO4910172A1 true CO4910172A1 (es) 2000-04-24

Family

ID=24682923

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97034165A CO4910172A1 (es) 1996-06-20 1997-06-19 Sistema de membrana de afinidad y metodo de uso del mismo

Country Status (17)

Country Link
US (2) US5868936A (es)
EP (1) EP0868208B1 (es)
KR (1) KR19990043992A (es)
CN (1) CN1196688A (es)
AR (1) AR007409A1 (es)
AT (1) ATE238095T1 (es)
AU (1) AU729964B2 (es)
BR (1) BR9702301A (es)
CA (1) CA2227550A1 (es)
CO (1) CO4910172A1 (es)
DE (1) DE69721223T2 (es)
ID (2) ID18738A (es)
IN (1) IN191816B (es)
MX (1) MX9801391A (es)
MY (1) MY132474A (es)
TW (1) TW389705B (es)
WO (1) WO1997048483A1 (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19748489A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
US6099730A (en) * 1997-11-14 2000-08-08 Massachusetts Institute Of Technology Apparatus for treating whole blood comprising concentric cylinders defining an annulus therebetween
US6919326B1 (en) * 1998-08-24 2005-07-19 Toshio Miyata Carbonyl-stress improving agent and peritoneal dialysate
DE69929986T2 (de) * 1998-08-31 2006-10-19 Ambrus, Julian L. Verfahren zur entfernung von hiv und anderen viren aus blut
WO2000041718A1 (en) * 1999-01-11 2000-07-20 Baxter International, Inc. Method and apparatus for selectively removing xenoreactive antibodies from blood, serum or plasma
WO2000074824A1 (en) * 1999-06-03 2000-12-14 Advanced Extravascular Systems One step removal of unwanted molecules from circulating blood
GB9926419D0 (en) * 1999-11-08 2000-01-12 Downstream Media Limited Methods and apparatus for capturing target substances from liquid media
AU2001249996A1 (en) * 2000-02-22 2001-09-03 Dudley Spencer Hemodialysis assembly and method
AUPQ697300A0 (en) * 2000-04-18 2000-05-11 Life Therapeutics Limited Separation apparatus
US8865172B2 (en) 2000-05-08 2014-10-21 Advanced Extravascular Systems, Inc. Method for reducing the number of unwanted molecules in bodily fluids
DE10036742A1 (de) * 2000-07-27 2002-02-21 Aesku Lab Diagnostika Vorrichtung zur Behandlung von Immunerkrankungen
JP4520621B2 (ja) * 2000-11-01 2010-08-11 信和化工株式会社 クロマトグラフィー用分離カラム、固相抽出用媒体、及びクロマトグラフィーの試料注入システム
US20040096821A1 (en) * 2001-02-05 2004-05-20 Keenan Elizabeth Ann Detection of micro-organisms
WO2003006676A2 (en) * 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
DE10147463B4 (de) * 2001-09-20 2009-03-19 Hemoteq Ag Verfahren zur Herstellung eines Absorbers, Absorber und dessen Verwendung
GB2387130A (en) * 2002-04-04 2003-10-08 Fluid Technologies Plc Hollow fibre filter membrane unit with microorganism detector, and associated usage
SE527054C2 (sv) * 2002-04-23 2005-12-13 Gambro Lundia Ab Förfarande för framställning av ett regioselektivt membran
AU2003281177A1 (en) * 2002-07-12 2004-02-02 Kuraray Co., Ltd. Porous membrane
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
JP2006516198A (ja) * 2002-09-05 2006-06-29 ミトラ メディカル アクティエボラーグ 新規組成物の使用及び方法
JP2007525232A (ja) 2003-01-17 2007-09-06 イースロン メディカル インコーポレイテッド レクチンアフィニティー血液透析による血液のウイルス除去方法
AT413336B (de) * 2003-09-12 2006-02-15 Mattner Frank Dr Apherese-vorrichtung
CA2575731C (en) 2003-12-24 2014-07-15 Chemica Technologies, Inc. Dialysate regeneration system for portable human dialysis
EP1712564B1 (en) * 2004-02-16 2011-07-20 Tsukao Yokoyama Anti-nc1 monoclonal antibody
EP1765228A4 (en) * 2004-06-28 2009-06-10 Haemonetics Corp BLOOD COMPONENT SEPARATION SYSTEM HAVING A FIXED SEPARATION COMPARTMENT
DE102004054747A1 (de) * 2004-11-12 2006-05-24 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zur Abreicherung wenigstens einer Komponente eines fluiden Mediums
US20060254984A1 (en) * 2005-05-16 2006-11-16 Uspolyresearch Hollow Fiber Membrane Adsorber and Process for the Use Thereof
DE102007019051B3 (de) * 2007-04-23 2008-10-09 Fresenius Medical Care Deutschland Gmbh Hohlfaserkapillarmembran und Verfahren zu deren Herstellung
US8202240B2 (en) * 2008-08-12 2012-06-19 Caridianbct, Inc. System and method for collecting plasma protein fractions from separated blood components
US8123713B2 (en) * 2008-08-12 2012-02-28 Caridian Bct, Inc. System and method for collecting plasma protein fractions from separated blood components
TWI469992B (zh) * 2008-08-28 2015-01-21 Baxter Int 濃縮剪切靈敏生物聚合物的方法
US8372287B2 (en) * 2008-09-02 2013-02-12 Als Group Usa, Corp Impregnated expanded polytetrafluoroethylene (ePTFE) tubing as a stationary phase
EP2161072A1 (en) * 2008-09-03 2010-03-10 Gambro Lundia AB High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients
US20100158893A1 (en) * 2008-12-19 2010-06-24 Baxter International Inc. Systems and methods for obtaining immunoglobulin from blood
DE102009022605B4 (de) 2009-05-26 2019-07-25 Lmb Lab Med Blutbank Technologie Gmbh Verfahren und Vorrichtung zum Auftrennen von Vollblut
KR101291245B1 (ko) * 2009-11-27 2013-07-30 한국전자통신연구원 미세유체제어 칩 및 미세유체제어 칩에서의 단백질 검출 방법
ITBO20100376A1 (it) * 2010-06-14 2011-12-15 Medica S P A Dispositivo adsorbente per il trattamento di liquidi
DE102010030238A1 (de) 2010-06-17 2011-12-22 Lmb Lab Med Blutbank Technologie Gmbh Durchflussfilter zum Separieren von Blut in Plasma und zelluläre Bestandteile
US20150158934A1 (en) 2011-09-09 2015-06-11 Ucl Business Plc Broadly neutralizing vhh against hiv-1
SE1200356A1 (sv) * 2011-10-30 2013-05-01 Kurt Nilsson Polymerbaserad produkt och användning
CN103045466B (zh) * 2012-12-31 2016-01-13 山东鑫科生物科技股份有限公司 血液微生物培养瓶
EP3016729B1 (fr) * 2013-07-05 2020-03-25 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Matrice de chromatographie d'affinité
EP3017835B1 (en) * 2014-07-31 2019-12-11 HIBAR Microsciences LLC Methods and apparatus for kidney dialysis and extracorporeal detoxification
EP3102224B1 (en) 2013-12-20 2019-02-20 NephroGenesis, LLC. Apparatuses for kidney dialysis and lipocalin protein for use in the prevention or treatment of uremia by dialysis
CN104931711A (zh) * 2015-06-25 2015-09-23 马鞍山海普微奇生物科技有限公司 一种促进生物试剂与生物分子结合的方法和装置
CN106268960B (zh) * 2016-09-27 2018-08-31 天津工业大学 一种聚丙烯腈纤维-hemin仿生催化剂及其制备方法
EP3400976A1 (en) * 2017-05-12 2018-11-14 Universitat Rovira i Virgili Device and method for the preparation of platelet rich plasma
CN108653846A (zh) * 2018-02-11 2018-10-16 武汉瑞法医疗器械有限公司 一体式血浆分离蛋白a免疫吸附器
ES2722802B2 (es) * 2018-02-14 2019-12-18 Fund De Neurociencias Dispositivo para la eliminacion selectiva de moleculas de tejidos o fluidos
US20200016520A1 (en) * 2018-07-11 2020-01-16 Attila Herczeg Single Pass Cross Flow Filtration Module And Method
CN109985607A (zh) * 2019-04-18 2019-07-09 中冶华天工程技术有限公司 一种用于污水处理的微囊藻球或微囊藻饼
WO2021262147A1 (en) * 2020-06-23 2021-12-30 Qualigen Inc. Devices and methods for on-line whole blood treatment

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742946A (en) * 1970-05-15 1973-07-03 C Grossman Apparatus for the in vivo treatment of blood containing harmful components resulting from chronic uremia and other conditions
US4045352A (en) * 1973-05-23 1977-08-30 California Institute Of Technology Ion-exchange hollow fibers
GB1512458A (en) * 1974-09-07 1978-06-01 Asahi Chemical Ind Liquid treatment apparatus with hollow fibre membranes
US4075100A (en) * 1974-12-04 1978-02-21 Asahi Kasei Kogyo Kabushiki Kaisha Dialysis unit and dialysis apparatus employing the dialysis unit
US4163714A (en) * 1975-11-07 1979-08-07 Gregor Harry P Separating substances with pressure-driven affinity sorption membranes
SE441143B (sv) * 1976-09-02 1985-09-16 Hoechst Ag Membranenhet och anordning for avlegsnande av metaboliter ur blod
IT1096208B (it) * 1978-05-12 1985-08-26 Snam Progetti Composizione adatta alla riduzione del tenore di fenilalanina e metodo impiegante la stessa
US4209392A (en) * 1978-05-15 1980-06-24 Wallace Richard A Portable hepatic-assist method and apparatus for same
US4247393A (en) * 1979-01-11 1981-01-27 Wallace Richard A Hemodialysis assist device
JPH0218858B2 (es) * 1979-06-11 1990-04-26 Gambro Lundia Ab
US4619639A (en) * 1980-02-05 1986-10-28 Asahi Medical Co., Ltd. Method and apparatus for low pressure filtration of plasma from blood
US4362155A (en) * 1981-03-24 1982-12-07 Skurkovich Simon V Method and apparatus for the treatment of autoimmune and allergic diseases
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
DE3423737A1 (de) * 1984-06-28 1986-01-02 Akzo Gmbh, 5600 Wuppertal Verfahren und vorrichtung zur kontinuierlichen dosierten entnahme oder zugabe von kleinen fluidmengen
JPH0611328B2 (ja) * 1984-10-11 1994-02-16 株式会社クラレ 生理活性物質を固定した多孔性中空繊維を使用した液の処理方法
JPS61119271A (ja) * 1984-11-13 1986-06-06 鐘淵化学工業株式会社 血液成分処理回路及び血液成分処理方法
US5144013A (en) * 1986-09-24 1992-09-01 Ube Industries, Ltd. Body fluid purifying material and method for purifying body fluid by use thereof
US4863611A (en) * 1987-04-30 1989-09-05 Massachusetts Institute Of Technology Extracorporeal reactors containing immobilized species
EP0319144A1 (en) * 1987-11-06 1989-06-07 Asahi Kasei Kogyo Kabushiki Kaisha Adsorbent of beta 2-microglobulin
US5216127A (en) * 1987-11-20 1993-06-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Adsorbent for serum amyloid protein
FR2628974A1 (fr) * 1988-03-25 1989-09-29 Hospal Ind Dispositif integre pour l'epuration biospecifique d'un liquide contenant des elements cellulaires
US5286449A (en) * 1988-04-04 1994-02-15 Asahi Medical Co., Ltd. Adsorber module for whole blood treatment and an adsorber apparatus containing the adsorber module
US5310688A (en) * 1988-10-31 1994-05-10 Sepracor Inc. Method and apparatus for eluting proteins in affinity membrane process
CA2001720C (en) * 1988-10-31 2001-10-02 Randal A. Goffe Membrane affinity apparatus and purification methods related thereto
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
US5275838A (en) * 1990-02-28 1994-01-04 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
US5171264A (en) * 1990-02-28 1992-12-15 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
US5418061A (en) * 1990-11-27 1995-05-23 W. R. Grace & Co.-Conn. Microporous polysulfone supports suitable for removal of low density lipoprotein-cholesterol
US5258149A (en) * 1990-11-27 1993-11-02 W. R. Grace & Co.-Conn. Process of making a membrane for high efficiency removal of low density lipoprotein-cholesterol from whole blood
US5187010A (en) * 1990-11-27 1993-02-16 W. R. Grace & Co.-Conn. Membrane having high affinity for low density lipoprotein-cholesterol from whole blood
US5236644A (en) * 1990-11-27 1993-08-17 W. R. Grace & Co.-Conn. Process of making membrane for removal of low density lipoprotein-cholesterol from whole blood
US5211850A (en) * 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
US5753227A (en) * 1993-07-23 1998-05-19 Strahilevitz; Meir Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases

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EP0868208A1 (en) 1998-10-07
TW389705B (en) 2000-05-11
US5868936A (en) 1999-02-09
ID18738A (id) 1998-05-07
DE69721223T2 (de) 2004-02-19
WO1997048483A1 (en) 1997-12-24
MX9801391A (es) 1998-11-30
AU3490497A (en) 1998-01-07
ATE238095T1 (de) 2003-05-15
ID29997A (id) 1997-12-25
IN191816B (es) 2004-01-03
EP0868208B1 (en) 2003-04-23
AU729964B2 (en) 2001-02-15
BR9702301A (pt) 1999-03-02
CN1196688A (zh) 1998-10-21
KR19990043992A (ko) 1999-06-25
MY132474A (en) 2007-10-31
DE69721223D1 (de) 2003-05-28
AR007409A1 (es) 1999-10-27
CA2227550A1 (en) 1997-12-24
US5871649A (en) 1999-02-16

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