CN1925840A - Substances with a probiotic action used in deodorants - Google Patents

Abstract

The invention relates to substances, in particular plant extracts, glycerine monoalkyl ethers and esters of organic acids, which have a probiotic action on the skin, in particular in the axillary area. The invention also relates to topical cosmetic and pharmaceutical compositions that contain said substances and to the use of said substances and compositions, in particular for combating body odour.

Description

Be used for the material that deodorizer has prebiotic effect

The present invention relates to material, plant extract particularly, described material has prebiotic effect to skin, arm-pit areas particularly, relate to and comprise partial makeup of these materials and Pharmaceutical composition, and relate to the purposes of these materials and compositions, especially for preventing body odor.

Body odor is because the antibacterial in the skin flora causes the degraded of perspiration composition.For this reason, the antibacterium material has been used for deodorizer for a long time.Yet, use non-selective antibiotic effective substances to have shortcoming, do not cause that promptly the antibacterial of stink also is suppressed or kills.Come from the skin care effect of these antibacterials, owing to utilize nonselective antibacterial activity composition therefore also destroyed.In addition, well-known is that the smelly effectiveness of many antibacterial activity composition antibody is very poor.Draw a conclusion thus, by using the antibacterial activity composition, the antibacterial that forms stink can not or can not fully be suppressed, and have bacillary symbiotic connecting each other (for example nobody knows the type that produces stink so far), promptly who forms the described material that the influence that produces is not used to body odor and solves.

Therefore need prevent the effective composition of body odor,, particularly have more those smelly compositionss of potent antibodies than known compositions up to now especially for arm-pit areas.These compositionss should equally advantageously have the selection that stink is formed microorganism.

Preferably the purpose of this invention is to provide a kind of skin composition in the present invention, compare, can promote microbial growth and/or physiologically active that the skin flora is wished with undesirable microbial growth and/or physiologically active in the skin flora.This material is also referred to as " prebiotics ".

Particularly, the objective of the invention is to find a kind of material, can promote neutral microbial growth of abnormal smells from the patient and/or physiologically active, and/or suppress to form stink and/or form bad smell microbial growth and/or physiologically active, in this case, can produce benefit in arm-pit areas especially and give birth to influence.

For arm-pit areas, so far there is not report to have the material of prebiotic effect, particularly be not reported in sacrifice to form stink and/or cause the bad smell microbial growth and/or the physiologically active situation under, can promote the material of neutral microbial growth of abnormal smells from the patient and/or physiologically active selectively.

Have the living demonstration that influences material of benefit and be only limited to intestinal so far basically.Therefore, various publications are described the material that uses the coliform growth that can promote needs.Ahn et al., (1990) Microbial Ecology in Health and Disease 3, also special public use ginseng extract among the 223-229.

For skin, only report oligosaccharide so far and can produce the living influence of benefit (advertisement pamphlet: Solabia Group, the BioEcolia of France ^) because it can preferably be utilized selectively by saprophytic antibacterial.In this respect, the oligosaccharide that has shown use, not only with but also, the mixture of having reported farnesol and xylitol in EP1050300 can be used as prebiotic substance, because this mixture has the antibacterial action of selecting for staphylococcus aureus, therefore can strengthen the microorganism staphylococcus epidermidis (S.epidermidis) of competition better.The growth of staphylococcus aureus (Staphylococcus aureus) and with the growth phase ratio of Corynebacterium xerose (Corynebacterium xerosis), can promote the growth of Micrococcus kristinae (Micrococcus kristinae).

And, the mixture of having reported farnesol and xylitol in EP1050300 can be used as prebiotic substance, because this mixture has the antibacterial action of selecting for staphylococcus aureus, therefore can strengthen the microorganism staphylococcus epidermidis (S.epidermidis) of competition better.

Described antibiotic and deodorant activities composition is the extract from prior art document EP 911019 and the known cedra fruits seed of JP9040516, although describe these the benefit fruit of not coming into force.

As the prerequisite of realizing the object of the invention, study to determine having the especially difference of the distribution of the microbiologic population between the male of strong and weak abnormal smells from the patient experimenter, so to find to form the microorganism of stink.In this, determined to have strong and/or make the experimenter of the unhappy body odor of people have different bacterial micro-organism group compositions with experimenter with weak body odor.

According to the present invention,, can find to have the following typical feature of strong body odor crowd by using the biomolecular science method:

A) the staphylococcus epidermidis mark reduces

B) staphylococcus hominis (Staphylococcus hominis) mark increases

C) Anaerococcus octavius mark increases slightly

D) specific corynebacterium (Corynebacterium) species mark increases slightly

To appear be particular importance to ratio between two kinds of staphylococcuses (Staphylococcus) species especially, in the present invention.The possible importance of described staphylococcus ratio to body odor do not disclosed in the prior art so far; Anaerococci to the report of the possible importance of body odor equally seldom.On the contrary, description of the Prior Art corynebacterium (Corynebacteria) and micrococcus (micrococci) be how to relate to stink to form.

Based on result of the present invention, study following material, described material, particularly by promoting the neutral microorganism of abnormal smells from the patient selectively, the neutral staphylococcus of abnormal smells from the patient particularly, it mainly is the growth of staphylococcus epidermidis, prevent to form the stink staphylococcus simultaneously, staphylococcus hominis particularly, and/or the positive anaerobic cocci of gram (dyeing), Streptacocci particularly, mainly be the growth of Anaerococcus octavius, and/or form the corynebacterium of stink, and/or form the micrococcus of stink, mainly be the growth of micrococcus luteus (Micrococcus luteus), can make to have strong stench experimenter or have the microbiologic population that makes the unhappy body odor experimenter of people to distribute towards having the direction change that weak stink experimenter microbiologic population distributes.The minimum requirements of this prebiotics is that inhibition forms the stink microorganism and directly do not influence the neutral microorganism of abnormal smells from the patient, perhaps promotes the neutral microorganism of abnormal smells from the patient and the directly microorganism of influence formation stink.

Surprisingly, the material of finding can be by promoting the growth and/or the physiologically active of staphylococcus epidermidis now, the growth and/or the physiologically active that suppress staphylococcus hominis simultaneously perhaps do not promote the growth of staphylococcus hominis at least, give birth to influence thereby skin is produced benefit.

In a preferred implementation, described plant extract is as follows:

1. from the extract (Cosmetochem of Fructus Vitis viniferae (Vitis viticola) seed; Water/propylene glycol extraction thing)

2. from the leaf extract of Ramulus et Folium Mussaendae Pubescentis (tea, Camellia sinensis), (Cosmetochem; Water/ethanol dry extract)

3. from the extract of carcade (Hibiscus syriacus L., the Sudan's tea, Calyx Hibisci Sabdariffae), (Cosmetochem; Water/ethanol dry extract)

4. from the flower extract of Radix Malvae sylvestris (Radix Malvae sylvestris, Malva sylvestris), (Cosmetochem; Water/ethanol dry extract)

5. from the extract of European grape (Vitis viticola), (Cosmetochem; Water/propylene glycol extraction thing)

6. the mixed extract of Radix Dauci Sativae and jojoba (Daucus carota L., Daucus carota, and jojoba, Simmondsia chinensis), (Flavex, CO2 extract)

7. from the extract of myrrh (myrrh, Commiphora myrrh), (Cosmetochem; Water/propylene glycol extraction thing)

8. from the extract of Flos Tagetis Erectae (Flos Inulae, Calendula officinalis), (Cosmetochem; Water/ethanol dry extract)

In other preferred implementation, described material with the living influence of benefit is glycerol monoalkyl ether and/or organic acid esters.

Therefore the present invention at first provides a kind of method of determining to have in arm-pit areas the prebiotic effect material, may further comprise the steps:

A) from have strong and weak stink experimenter, obtain comparative sample,

B) composition of the methods analyst comparative sample by biomolecular science is determined to compare in having strong stench experimenter to a greater extent or the microorganism that occurs on the littler degree with having weak stink experimenter,

C) search material goods storehouse suppresses the material that there is the growth of microorganism of degree increase in described basis (b) to seek, and/or promotes to exist according to (b) material of the lower growth of microorganism of degree.

Therefore the present invention further provides and a kind ofly determine at skin, particularly arm-pit areas has the method for prebiotic effect material, be characterised in that the material that research is following, described material can make the microbiologic population with strong stench experimenter distribute towards having the direction change that weak stink experimenter microbiologic population distributes, and/or study following material, described material promotes the neutral microorganism of abnormal smells from the patient selectively, the neutral staphylococcus of abnormal smells from the patient particularly, mainly be the growth and/or the physiologically active of staphylococcus epidermidis, and/or inhibition forms the stink staphylococcus simultaneously, staphylococcus hominis particularly, and/or the positive anaerobic coccus of gram (dyeing), Streptococci particularly, mainly be Anaerococcus octavius, and/or the corynebacterium of formation stink, and/or the micrococcus of formation stink, mainly be the growth and/or the physiologically active of micrococcus luteus.For example carry out the material search in the present invention by screening material goods storehouse.Described in the present invention prebiotics suppresses to form stink microbial growth and/or physiologically active at least and does not directly influence the neutral microorganism of abnormal smells from the patient, perhaps they promote the neutral microbial growth of abnormal smells from the patient and/or physiologically active at least and directly influence form the microorganism of stink.In special preferred implementation, research suppresses the growth and/or the physiologically active of staphylococcus hominis, does not influence simultaneously or promotes the growth of staphylococcus epidermidis and/or the microorganism of physiologically active.

According to the present invention, the positive anaerobic cocci of described gram (dyeing) is Peptostreptococcus (Peptostreptococcus) antibacterial preferably.The generic name Peptostreptococcus comprises that the synonym of genus do not understand sugar and have a liking for peptone Pseudomonas (Peptoniphilus), Gallicola, Slackia, anaerobic cocci belongs to (Anaerococcus) (comprising Anaerococcus octavius), Finegoldia, little unit cell belongs to (Micromonas), strange thing Pseudomonas (Atopobium) and Ruminococcus (Ruminococcus).Therefore material of the present invention is selected from the antibacterial of these genus in the preferred implementation to its positive anaerobic cocci of gram (dyeing) that effectively participates in the formation body odor.

According to the present invention, prebiotic effect is understood that implication is: with undesirable, particularly skin is disagreeableness and/or form the skin microorganism of stink or the growth and/or the survival ability of microbiologic population compared, and the growth and/or the physiologically active of neutral skin microorganism of the particularly skin-friendly of hope and/or abnormal smells from the patient or microbiologic population are promoted.This can or directly not influence active component realization of undesirable skin growth of microorganism by the skin microbial growth that promotes hope, the perhaps not directly active component realization of the skin growth of microorganism of influence hope by suppressing undesirable skin microbial growth.Yet in particularly preferred according to a present invention and surprising especially embodiment, described active component promotes the skin microbial growth of hope, suppresses undesirable skin microbial growth simultaneously.

Unfriendly and/or the pathogenic microorganism of described in the present invention undesirable microorganism, particularly skin and/or have with healthy physiognomy than the microorganism that has too high microbe density, therefore,, can produce undesirable and/or pathogenic influence in some cases.Yet described undesirable microorganism also can be the microorganism that forms the microorganism of stink or cause bad smell.

Therefore, the microbiologic population of described hope in the present invention is skin-friendly and/or non-pathogenic microorganism particularly, the flora of resident skin particularly, saprophytic microbe, perhaps other, under body odor situation for example, the neutral microorganism that does not promptly produce the foul odour chemical compound of abnormal smells from the patient from perspiration composition or other material.Especially, should consider in the present invention, by promoting to wish microbial growth, suppress undesirable microorganism, vice versa by suppressing not to wish microbial growth, promotes to wish microbial growth, meaning to produce the benefit fruit of coming into force in many ways.

Under (irritating) body odor, particularly axillary fossa stink situation, undesirable microorganism needs not to be pathogenic microorganism, and the microorganism of formation stink itself is the microorganism of skin-friendly equally naturally.Under (irritating) body odor situation, therefore described undesirable microorganism is defined as and causes body odor.In this, prebiotic substance is characterised in that the following fact: it is sacrificing the neutral microbial growth of promotion abnormal smells from the patient under the situation that forms stink (causing the offending body odor of people) growth of microorganism.

According to the present invention, " forming the stink microorganism " or " stink microorganism " are understood to mean in principle and are present in the microorganism that degree increases among the body odor crowd.These are preferred or itself produce the microorganism that causes the bad smell material, or promote to cause the microorganism of bad smell material formation.And these microorganisms may be, for example by producing this material, or to promote to form by means of other microbial transformation be the material that makes the unhappy odoring substance of people, and the microorganism that in forming this material, only directly relates to.According to the present invention, the microorganism of described formation stink may not itself cause bad smell, also can relate to the metabolism of the formation stink that carries out with other approach.

The present invention further provides purposes with prebiotic effect material, especially have skin, particularly in the purposes of the material of arm-pit areas prebiotic effect, described material is plant extract particularly, glycerol monoalkyl ether or organic acid ester, with skin microbial growth and/or the physiologically active that promotes to wish, preferably benign and/or non-pathogenic and/or skin-friendly of the skin microorganism of wherein said hope and/or saprophytic skin microorganism and/or, particularly preferably be the neutral microorganism of abnormal smells from the patient, the neutral coagulase negative staphylococcus of abnormal smells from the patient (coagulase-negative Staphylococci) particularly, staphylococcus epidermidis especially in the present invention.

Therefore the present invention further provides the purposes with prebiotic effect material, especially have skin, particularly in the purposes of the material of arm-pit areas prebiotic effect, described material is plant extract particularly, glycerol monoalkyl ether or organic acid ester, to suppress undesirable skin microbial growth and/or physiologically active, wherein said undesirable microorganism is disagreeableness microorganism of skin and/or pathogenic microorganism preferably, and/or particularly preferably be the microorganism that forms stink, particularly form the staphylococcus of stink, it mainly is staphylococcus hominis, form gram (dyeing) the positive anaerobic cocci, particularly peptostreptococcus (Peptostreptococci) of stink, especially anaerobic cocci belongs to octavius, and/or micrococcus, the especially micrococcus luteus of the corynebacterium of formation stink and/or formation stink.

Under special each situation in the present invention, described purposes can be used for makeup with in the local skin care composition, and the composition of described compositions is further definition in this description.

According to the present invention, term " skin " is the skin of skin itself, particularly people preferably, but also refer in addition mucosa and, the skin appendage, if they comprise living cells, hair follicle particularly, Rhizoma Imperatae, ball top, the outside of belly epithelium of nail matrix (Lectulus) and sebaceous gland and sweat gland.In a preferred implementation, skin is interpreted as the skin that is meant at arm-pit areas (axillary fossa) according to the present invention.

Preferably, be suitable for making appearing at according to the material that has the skin beneficiating effect of giving birth to of the present invention having strong and/or making distribute microbiologic population's changes in distribution in appearing at the smelly crowd of belt body not of microbiologic population among the unhappy body odor crowd of people, perhaps can repair and/or stablize this microbiologic population and distribute.

Therefore the present invention further provides a kind of prebiotic substance, preferably by means of promoting the neutral staphylococcus of abnormal smells from the patient, the growth of special staphylococcus epidermidis, and/or inhibition forms the staphylococcus of stink, the particularly growth of staphylococcus hominis, and/or the positive anaerobic cocci of inhibition gram (dyeing), particularly anaerobic cocci belongs to the growth of octavius, and/or the micrococcus that suppresses to form the corynebacterium of stink and/or form stink, the particularly growth of micrococcus luteus, described material have the effect that suppresses stink in arm-pit areas.

In the particularly preferred embodiment of the present invention, described material with prebiotic effect is a plant extract, glycerol monoalkyl ether or organic acid ester, can promote the neutral coagulase negative staphylococcus of abnormal smells from the patient, the particularly growth of staphylococcus epidermidis, show to forming the stink staphylococcus inhibition of special staphylococcus hominis growth or do not produce direct influence simultaneously.

In the particularly preferred embodiment of the present invention, described material with prebiotic effect is a plant extract, glycerol monoalkyl ether or organic acid ester, to forming the stink staphylococcus, the growth of special staphylococcus hominis has depression effect, show the growth that can promote abnormal smells from the patient neutral coagulase negative staphylococcus, particularly staphylococcus epidermidis simultaneously, perhaps do not have a direct impact.

The present invention further provides described purposes with prebiotic effect material, particularly has the purposes of skin beneficiating being given birth to working substance, mainly, be used for cosmetic local skin care composition with the treatment body odor, especially in arm-pit areas by in deodorizer and/or anti-perspirant, using.

The present invention further provides described purposes with prebiotic effect material, the purposes that particularly skin is had the material of prebiotic effect, be used for cosmetic local skin care composition with the treatment spot, dry or greasy skin and the treatment dermatophytes or the dandruff.

Among the present invention under each situation described nursing also refer to preventative or prophylactic.

The present invention further provides a kind of cosmetic or Pharmaceutical composition, comprise material with effect that skin beneficiating is given birth to, especially the plant extract that skin is had prebiotic effect, the glycerol monoalkyl ether that skin is had prebiotic effect, the organic acid esters that skin is had prebiotic effect, perhaps its mixture, wherein said cosmetic or Pharmaceutical composition be local skin care composition, particularly deodorizer and/or anti-perspirant preferably.

Have the content of material in the present composition of prebiotic effect, be preferably 0.01-20wt% based on described composition total weight, be preferably 0.05-10wt% especially, especially 0.1-5wt% is in particular 0.1-1.5wt%, perhaps 0.5-2wt%.

Plant extract with prebiotic effect of the present invention is Folium Camelliae sinensis extract preferably, from Theaceae or the extract from Malvaceae, is from Vitaceae particularly, umbrella flower section, the extract in the Buxaceae, the perhaps extract from Radix Asteris section or its mixture.Special preferred extract from Vitaceae.

The Theaceae extract is the extract from the Flos Camelliae Japonicae kind preferably, especially the extract from Ramulus et Folium Mussaendae Pubescentis (tea, Camellia sinensis).In a preferred implementation, be the extract from blade, as getable from Cosmetochem.

Extract from Malvaceae is the extract from the Hibiscus kind preferably, especially from the Sudan's Folium Camelliae sinensis (carcade, Hibiscus syriacus L., Calyx Hibisci Sabdariffae) extract in, the perhaps extract from the Radix Malvae sylvestris kind is especially from Radix Malvae sylvestris (Radix Malvae sylvestris, Malva sylvestris), the extract in the special Radix Malvae sylvestris.

Extract from Vitaceae is the extract from the Fructus Vitis viniferae kind preferably, particularly the extract from Fructus Vitis viniferae (Vitis viticola).Among the present invention, particularly preferably be the extract from Semen Vitis viniferae.

Extract from umbrella flower section is the extract from wild celery kind preferably, especially the extract from Radix Dauci Sativae (Daucus carota L., Daucus carota), the perhaps extract from the bdellium kind, especially the extract from myrrh (bdellium myrrh, Commiphora myrrh).In a preferred implementation, be the extract from root, as getable from Cosmetochem or Rahn.

Extract from Buxaceae is the extract from the Jojoba genera kind preferably, especially the extract from jojoba (jojoba, Simmondsia chinensis).

Extract from Radix Asteris section is the extract from the Calendula kind preferably, especially the extract from Flos Tagetis Erectae (Flos Inulae, Calendula officinalis).

Above-mentioned plant extract is for example getable from Cosmetochem of company (Germany) or Rahn (Germany).

Any way that plant extract with prebiotic effect in principle can those of ordinary skills be known uses the plant tissue of any hope and uses the extractant preparation of any hope.At first, described plant extract can be for example by the extraction whole plants, by extracting flower, blade, seed, root, and/or the separate living tissue of extraction plant and carrying out.

The extractant that is used for producing described plant extract for example can be water, alcohol and its mixture.Suitable alcohol for example is lower alcohol, for example ethanol and isopropyl alcohol, but especially also can be polyhydric alcohol, ethylene glycol for example, propylene glycol and butanediol, perhaps as only extractant, perhaps as with the mixture of water.Therefore be 1 based on the ratio of water/propylene glycol for example: 10-10: 1 plant extract proves suitable especially.Described extraction can for example be carried out with the steam distillation form.In some cases, also can carry out the extraction of dry type.

After the described extraction, described extract also can be applied to carrier, in particular for introducing in the product better.Appropriate carriers of the present invention for example is maltodextrin and Talcum.In a preferred embodiment of the invention, the preparation that extract will be used for is depended in the selection of extract.For example moisture and alcoholic extract, water/propylene glycol extraction thing particularly, be preferred for aqueous or contain in the alcohol formulations, in the perhaps soapy club, the molten extract of oil is preferred in the oil-including formulation, particularly in bar-shaped antiperspirant or antiperspirant aerosol, the extract on maltodextrin based carrier or be used for hydrophilic or hydrophobic product, the extract on the Talcum carrier is preferred in the hydrophobic product.

Therefore, the present invention also provides a kind of cosmetic or Pharmaceutical composition especially, it is included in carrier, the plant extract with prebiotic effect of the present invention on Talcum carrier or maltodextrin based carrier particularly, those at least a as mentioned above particularly, described compositions used according to the invention proves particularly advantageous.

From Theaceae, extract in Malvaceae and the Radix Asteris section is water/propylene glycol extraction thing preferably, perhaps water/ethanol dry extract, perhaps water/the ethanol extraction on maltodextrin or Talcum carrier, extract from Vitaceae is water/propylene glycol extraction liquid preferably, extracting solution from umbrella flower section is carbon dioxide extraction liquid preferably, perhaps water/propylene glycol extraction liquid, and the extracting solution from Buxaceae is carbon dioxide extraction liquid preferably.

According to the present invention skin is had the plant extract of prebiotic effect or use with the pure material form or with dilute form.If they use with dilute form, they comprise the active substance of about 2-80wt% usually and are used for their isolating extractants or extractant mixture as solvent.The extractant that depends on selection is preferably stablized described plant extract by adding solubilizing agent.Appropriate solubilizing agent for example is the ethoxylated products of optionally hydrogenated plant and animal oil.Preferred solubilizing agent is the list with C8-22 fatty acid of the ethoxylation of 4-50 ethylene oxide unit, two and triglyceride, for example hydrogenant ethoxylated castor oil, the olive oil ethoxylate, the almond oil ethoxylate, ermine oil ethoxylate, polyoxyethylene glycol caprylic/capric glyceride, polyoxyethylene glyceryl monolaurate and polyoxyethylene glycol cocoa fat acid glyceride.

Described glycerol monoalkyl ether with prebiotic effect is the 1-alkyl glycerylether preferably.Alkyl described in the present invention is (C preferably ₂-C ₁₄)-, be (C particularly ₄-C ₁₂)-, be (C especially ₆-C ₁₀) alkyl, wherein said alkyl can be straight chain or side chain.In a special preferred implementation, described alkyl is octyl group and/or alkyl hexyl, particularly ethylhexyl, especially the 2-ethylhexyl of side chain.1-(2-ethylhexyl) glycerin ether is for example with trade name Sensiva  SC 50 (Sch ü lke﹠amp; Mayr is getable Germany).

Organic acid esters with prebiotic effect is (C preferably ₁₀-C ₁₈) carboxylic acid and (C ₁-C ₁₀) ester of alcohol, wherein said hydroxy-acid group or described alcohol radical can straight chains or side chain, and be saturated or undersaturated, and the alkyl of wherein said hydroxy-acid group and described alcohol radical independently of one another can the one or more substituent groups of carrier band, are selected from (C especially ₁-C ₆) alkyl and hydroxyl.Described carboxylic acid particularly preferably is (C ₁₂-C ₁₆) carboxylic acid, especially C ₁₄Carboxylic acid, particularly myristic acid.Preferred especially (the C of described alcohol ₁-C ₆) alkanol, especially methanol, ethanol, propanol, particularly 1-propanol, 2-propanol or isopropyl alcohol, butanols, particularly 1-butanols, the 2-butanols or the tert-butyl alcohol, amylalcohol, particularly 1-amylalcohol, the 2-amylalcohol, the 3-amylalcohol, 2-methyl-1-butene alcohol, 3-methyl isophthalic acid-butanols, 2-methyl-2-butanols, perhaps 3-methyl-2-butanols.In special preferred implementation, described ester with prebiotic effect is isopropyl myristate or myristic acid ethyl ester.

Cosmetic of the present invention or Pharmaceutical composition can be the forms that gives of any hope, for example solid or liquid soap, washing liquid, spray, cream, gelinite, emulsion, cleanout fluid or cleaning Emulsion, deodorizer, anti-perspirant, ointment, hair-care agent or shampoo perhaps also may reside in giving in the form of any of description or other, for example also may reside in the ointment, particularly in gelinite storage or saving ointment or the substrate ointment.

In the particularly preferred embodiment of the present invention, described cosmetic or Pharmaceutical composition are deodorizer and/or anti-perspirant.Deodorizer described in the present invention and/or anti-perspirant preferred form are powder, and be bar-shaped, synthetic detergent, cleaning mixture, aerosol spray, pump sprays, liquid or gel roll puts formula container dress deodorizer, cream on the skin, foam, liquid or bar soap, the flexible substrate of gelinite or dipping.

Therefore, depend on the application scenario form can as loader for example be bar-shaped clamper, roll and put the formula container on the skin, pump, pipe, pipkin, allotter is wiped, aerosol can or bottle.

The suitable skin that the position is any zone of health, particularly Mian Bu skin, scalp, the skin of foot and hands of applying.In a special preferred implementation, describedly apply the skin that the position is described arm-pit areas.

Cosmetic of the present invention or Pharmaceutical composition also can comprise those compositions that are different from above definition.In a preferred implementation, it comprises lists at least a of following material at least.It also can comprise the compositions of listing in following composition of any hope.

Particularly, prove to the particularly advantageous cosmetic of the present invention or Pharmaceutical composition it is to comprise at least a skin to be had those of prebiotic effect plant extract of the present invention and at least a glycerol monoalkyl ether mixture that skin is had a prebiotic effect.

In addition, prove to the particularly advantageous cosmetic of the present invention or Pharmaceutical composition it is to comprise at least a skin to be had prebiotic effect material of the present invention and at least a deodorizer active component, particularly have the material of antibacterial action.Under the situation that the deodorizer active component is used with, occur favourable cooperative effect at material among the present invention, be that promptly generally speaking bacterial population reduces with prebiotic effect, but undesirable antibacterial than the antibacterial of wishing selected killing to a greater extent.Because this comprehensive effect, compare the antibacterial of described hope thereby can even on skin, propagate to a greater extent in some cases with the pure benefit situation that fruit exists that comes into force.

In one embodiment of the present invention, except that at least a plant extract with prebiotic effect of the present invention, described compositions also comprises at least a other plant extract.This other plant extract can be for example by the whole plant preparation of extraction, and can be only by preparing from flower and/or blade and/or seed and/or the extraction of other plant part.According to the present invention, from separate living tissue, the plant that promptly can separate generates extract and the extract from following concrete plant in the tissue: green tea for example, Hamamelis virginiana, Flos Chrysanthemi, Herba Violae Hortensis, Radix Paeoniae, Aloe, Aesculus chinensis Bunge, salvia, Willow bark, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Chrysanthemi, oak bark, small British nettle, hop, Fructus Arctii, Herba Equiseti Arvinsis, Fructus Crataegi, Flos tiliae miquelianae, Semen Armeniacae Amarum, fir needle, sandalwood, juniper, Cortex cocois radicis, Fructus Averrhoae Carambolae, Punica granatum L., tilia, Fructus Mangifera Indicae, Fructus Pruni, Semen Tritici aestivi, Fructus Melo, Fructus Citri junoris, grapefruit, American Avocado Tree, Herba Rosmarini Officinalis, birch, Fagus sinensis Oliv. branch, garment or robe made of feathers grass, achillea millefolium, wild thyme, Herba thymi vulgaris, Herba leucadis ciliatae, restharrow, Althaea officinalis L. (Althaea), violet, Ribes nigrum L. blade, coltsfoot, cincfoil, Radix Ginseng, race and Rhizoma Dioscoreae esculentae are preferred as other plant extract.Also can advantageously use algae extract.Algae extract used according to the invention derives from green algae, Brown algae, red algae or cyanophyceae (cyanobacteria).The algae that is used to extract can be a natural origin, perhaps obtains by biotechnological method, if wish that the described native form of comparing carries out modification.Described organic modification can be passed through genetic engineering, is undertaken by growth in being rich in the medium of selecting nutrient or cultivation.Preferred algae extract derives from Sargassum, cyanophyceae, chlorella pine Trentepohlia tomentosum and Brown algae fucus vesiculosus.Particularly preferred algae extracting solution derives from the spirulina species of the cyanophyceae of cultivating in rich magnesium culture medium.

As other plant extract, especially preferably from spirulina, green tea, Aloe, separate living tissue, Hamamelis virginiana, Fructus Pruni, Punica granatum L., Rhizoma Dioscoreae esculentae, tilia, Fructus Mangifera Indicae, Fructus Averrhoae Carambolae, Fructus Cucumidis sativi, Radix Malvae sylvestris, the extract of Althaea officinalis L. and violet.As other plant extract, compositions of the present invention also can comprise two or more, particularly the mixture of two kinds of different plant extracts.

Having the plant extract of prebiotic effect as for preparation, can for example be water as the extractant of the specific other plant extract of preparation, pure and mild its mixture.In described alcohol, preferred lower alcohol among the present invention, for example ethanol and isopropyl alcohol, but be in particular polyhydric alcohol, ethylene glycol for example, propylene glycol and butanediol, perhaps as only extractant or as with the mixture of water.Based on ratio is 1: 10-10: the plant extract of water/propylene glycol of 1 proves suitable especially.According to the present invention, steam distillation belongs to preferred extraction method.Yet in some cases, described extraction also can dry type extraction form be carried out.

According to the present invention, described plant extract can pure material form or dilute form use.If they use with dilute form, they comprise the active substance of about 2-80wt% usually and are used for their isolating extractants or extractant mixture as solvent.The extractant that depends on selection is preferably stablized described plant extract by adding solubilizing agent.Appropriate solubilizing agent for example is the ethoxylated products of optionally hydrogenated plant and animal oil.Preferred solubilizing agent is the C with ethoxylation of 4-50 ethylene oxide unit _8-22The list of fatty acid, two and triglyceride, for example hydrogenant ethoxylated castor oil, the olive oil ethoxylate, the almond oil ethoxylate, ermine oil ethoxylate, polyoxyethylene glycol caprylic/capric glyceride, polyoxyethylene glyceryl monolaurate and polyoxyethylene glycol cocoa fat acid glyceride.

In addition, in compositions of the present invention, except that plant extract, also preferably use two or more, particularly the mixture of two kinds of different plant extracts with prebiotic effect.

As for being used as plant extract of the present invention, also can be with reference at IndustrieverbandK  rperpflege-und Waschmittel e.V. (IKW), the extract of listing in the table of the 44th page of beginning of the third edition is introduced in the cosmetic composition composition explanation that Frankfurt publishes.

Described cosmetic or Pharmaceutical composition, particularly the present invention preferably comprise deodorizer or the antiperspirant compositions that the present invention has the prebiotic effect material also can comprise lipid.Lipid is understood to mean fatty acid, aliphatic alcohol, and natural and synthetic oil for cosmetic purpose component, natural and synthetic paraffin, they can solid-state existence or other liquid existence as moisture or oil dispersion form.

The fatty acid that can be used is straight chain and/or side chain, saturated and/or unsaturated C _8-30Fatty acid.Preferred C _10-22Fatty acid.Example is a caproic acid, and is sad, 2 ethyl hexanoic acid, capric acid, lauric acid, different tridecanoic acid, myristic acid, Palmic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselic acid, linoleic acid, linolenic acid, eleostearic acid, arachidonic acid, gaducene acid, mountain Yu's acid and erucic acid and its industrial grade mixture.It is particularly preferred using stearic acid.The fatty acid of described use can the one or more hydroxyls of carrier band.Its preferred example is Alpha-hydroxy-C ₈-C ₁₈Carboxylic acid and 12-hydroxy stearic acid.Use amount is 0.1-15wt% based on total composition under each situation among the present invention, preferred 0.5-10wt%, preferred especially 1-5wt%.

The aliphatic alcohol that can be used is saturated, single or polyunsaturated side chain or unbranchedly have 6-30, preferred 10-22, the aliphatic alcohol of 12-22 carbon atom very particularly preferably.For example, (just) decanol, (just) capryl alcohol, matsutake alcohol, lanolin alcohol, decenol, octadienol, Pherocon CM, decadinene alcohol, oleyl alcohol, mustard alcohol, ricinoleyl alcohol, octadecanol, isooctadecane base alcohol, hexadecanol, lauryl alcohol, tetradecanol, arachidic alcohol, capryl alcohol, decanol, inferior oleyl alcohol, linolenyl alcohol and behenyl alcohol and its lid that shellfish alcohol can be used for purpose of the present invention.

Wax is generally used for bar-shaped preparation.Operable natural or synthetic paraffin is hard paraffin or isoparaffin according to the present invention, and vegetable wax is candelilla wax for example, Brazil wax, alfa wax, Japan wax, cork wax, sugarcane wax, ouricury wax, montan wax, Helianthi wax, fruit wax and animal wax be Cera Flava for example, and other insect waxes, spermaceti, shellac wax, the cream of lanocerin and tail fat, mineral tallow in addition, for example ceresin and ceresine, perhaps petroleum chemicals wax, vaseline for example, paraffin, polyethylene or polyacrylic microwax, and polyethylene glycol wax.Advantageously use hydrogenation wax.In addition, also can use the wax, particularly hard wax of chemical modification, for example brown coal ester type waxes, Sa Suoer wax and hydrogenation jojoba wax.

Same suitable is saturated, optional hydroxylated C _16-30The list of fatty acid, two and triglyceride, hydrogenation triglyceride fat (hydrogenated palm oil, hydrogenated coconut oil, castor oil hydrogenated) for example, glyceryl monostearate (Cutina ^MD), three Glyceryl Behenates, perhaps three-12-hydroxy stearic acid glyceride can be fatty acid and the glycol with 2-6 carbon atom (Syncrowachs for example equally ^) or the full esters of polyol and have C _12-22Acyl group and _C2-4The fatty acid monoalkylol amide of silane alcohol base, chain length be 1-80 carbon atom saturated and/or unsaturated, side chain and/or unbranched alkanoic acid, with chain length be 1-80 carbon atom saturated and/or unsaturated, the esters of side chain and/or unbranched alcohol, comprise for example synthetic fatty acid-aliphatic alcohol esters, stearic acid stearyl for example, perhaps cetyl palmitate, aromatic carboxylic acids, dicarboxylic acids and hydroxy carboxylic acid (for example 12-hydroxy stearic acid) and chain length be 1-80 carbon atom saturated and/or unsaturated, the esters of side chain and/or unbranched alcohol, the lactide of long-chain hydroxy carboxylic acid, with aliphatic alcohol and two and tricarboxylic full esters, for example succinic acid dicetyl ester, perhaps adipic acid dicetyl/stearyl, with the mixture of these materials, condition is that single wax component or their mixture at room temperature are solids.

Particularly preferably be and select following wax component: chain length is that 14-44 carbon atom is saturated, unbranched alkanoic acid and chain length are that 14-44 carbon atom is saturated, the esters of unbranched alcohol, condition are that described wax component or described whole wax component at room temperature are solids.Described wax component can particularly advantageously be selected from stearic acid C _16-36Arrcostab, stearic acid C _10-40Arrcostab, isostearate C _2-40Arrcostab, dimeric dibasic acid C _20-40Dialkyl, stearic acid C _18-38The stearic alcohol ester of alkyl hydroxy, erucic acid C _20-40Arrcostab can use C in addition _30-50Alkyl Cera Flava and mountain Yu acid 16/stearyl.Silicone wax, for example hard ester-trimethyl silane/octadecanol is being favourable in some cases equally.Particularly preferred wax component is saturated, monohydroxy C ₂₀-C ₆₀Pure and saturated C _8-30Monocarboxylic esters particularly preferably is stearic acid C ₂₀-C ₄₀Arrcostab can title Kesterwachs ^K82H obtains from Koster Keunen Inc..Described wax or wax component should be solids at 25 ℃, but 35-95 ℃ of scope fusion, wherein preferable range is 45-85 ℃.

Natural, can being used alone or in combination of chemical modification with synthetic paraffin.

Described wax component is based on total composition, and content is 0.1-40wt%, and preferred 1-30wt% is in particular 5-15wt%.

Compositions of the present invention also can comprise at least a natural or synthetic nonpolar or polar liquid is oily.Described polar line of oils part is selected from vegetable oil, Oleum helianthi for example, and olive oil, Oleum Glycines, Oleum Brassicae campestris, almond oil, the liquid distillate of jojoba oil and Oleum Cocois, synthetic triglyceride oil is selected from ester oil, i.e. C _6-30Fatty acid and C _2-30The esters of aliphatic alcohol, be selected from dicarboxylic ester, adipic acid-di-n butyl ester for example, adipic acid two (2-ethylhexyl) ester, with succinic acid two (2-ethylhexyl) ester, and diol-lipid, two oleic acid glycol esters for example, two (2 ethyl hexanoic acid) propylene glycol ester, be selected from symmetric, the ester of asymmetrical or cyclic carbonic acid and aliphatic alcohol for example is described among the DE-A197 56 454, carbonic acid glyceride or dicaprylyl carbonate (Cetiol ^CC), be selected from list saturated and/or unsaturated straight chain and/or branched chain fatty acid and glycerol, two and tri-fatty acid ester, be selected from branched alkanol, the lid that shellfish alcohol that for example on the 2nd carbon atom, has single side chain, 2-hexadecanol for example, the 2-octadecanol, different tridecyl alcohol and 2-Methylpentadecane alcohol are selected from alkanediol, for example by in the presence of water, carrying out open loop from having the obtainable ortho position of the epoxyalkane hydrocarbon glycol of 12-24 carbon atom, be selected from ether alcohol, glycerol for example, ethylene glycol, 1,2-propylene glycol or 1, the monoalky lether of 2-butanediol is selected from the dialkyl ethers that has 12-24 carbon atom under each situation, the alkyl methyl ether or the two positive alkyl ethers, particularly di-n-octylether (Cetiol that for example under each situation, have 12-24 carbon atom altogether ^OE ex Cognis), be selected from oxirane and/or expoxy propane at single or polyhydric C3-20 the alkanol for example addition compound product on butanols and the glycerol, for example PPG-3 myristyl ether (Witconol ^APM), PPG-14 butyl ether (Ucon Fluid ^AP), PPG-15 octadecyl ether (Arlamol ^E), PPG-9 butyl ether (Breox ^B25) and PPG-10 butanediol (Macol  57).Described nonpolar line of oils part can be selected from saxol, isoparaffinic oil, for example 2-Methylpentadecane and Isoeicosane, be selected from the hydrogenation polyolefin, particularly poly--1-decene (can obtain (Fortum as Nexbase 2006 or 2008FG commerce, Belgium)), be selected from synthetic hydrocarbon, for example 1,3-two (2-ethylhexyl) cyclohexane extraction (Cetiol  S), with be selected from volatile and nonvolatile silicone oil, can be cyclic, for example decamethyl ring five polysiloxanes and decamethyl ring six polysiloxanes, or straight chain, straight chain dimethicone for example, for example with Dow Corning  190,200,244,245,344 or 345 and Baysilon  350M can commercial obtain.

Compositions of the present invention also can comprise the alcohol of at least a water dissolvable.According to the present invention, the dissolubility in the water is interpreted as and is meant that under 20 ℃ the dissolving of the alcohol of 5wt% obtains clear solution at least, or-under long-chain or polymeric alcohol situation-obtain solution by described solution being heated to 50 ℃-60 ℃.Depend on the form of giving, monohydric alcohol is ethanol for example, propanol, and perhaps isopropyl alcohol is suitable.The polyol of water soluble is suitable equally.These comprise the glycol of water soluble, the alcohol of three pure and mild senior hydroxyls, and Polyethylene Glycol.In described glycol, C ₂-C ₁₂Glycol is suitable, particularly 1, and 2-propylene glycol, butanediol, for example 1,2-butanediol, 1,3 butylene glycol and 1,4-butanediol, hexanediol for example 1,6-hexanediol.Same preferred suitable be glycerol, particularly diglycerol and triglycerin, 1,2,6-hexanetriol, dipropylene glycol and Polyethylene Glycol (PEG) PEG-400, PEG-600, PEG-1000, PEG-1550, PEG-3000 and PEG-4000.

The content of alcohol or alcohol mixture is 1-50wt% or 1-70wt% based on total composition in the present composition, preferred 5-40wt% or 5-55wt%.According to the present invention, can use a kind of alcohol or two or more pure mixture.

Compositions of the present invention can be anhydrous basically, promptly comprises maximum 5wt%, the preferred water of 1wt% at most.Giving in the form of hydration, based on total composition, water content is 5-98wt%, preferred 10-90wt%, preferred especially 15-85wt%.

Compositions of the present invention also can comprise at least a hydrophilically modified polysiloxanes.They can provide the composite preparation of highly transparent, reduce viscosity and stay salubrious sensation on skin.According to the present invention, hydrophilically modified siloxanes is interpreted as and is meant and contains the polysiloxane that makes siloxanes cause deliquescent hydrophilic component in water.According to the present invention, the dissolubility in the water is interpreted as and is meant that under 20 ℃ the polysiloxanes that contains the hydrophilic group modification of 2wt% dissolves at least in water.Corresponding hydrophilic substituent for example is a hydroxyl, Polyethylene Glycol or polyethylene/polypropylene glycol side chain and hydroxyethylation ester side chain.What preferably be fit to according to the present invention is hydrophilically modified polysiloxane copolymer, particularly contains the dimethione of polyoxyethylene or polyoxypropylene side chain, for example by Wacker-Chemie with Belsil ^DMC 6031, Belsil ^DMC 6032, Belsil ^DMC 6038 or Belsil ^DMC 3071 VP titles are perhaps sold with DC 2501 titles by DowCorning.That especially preferably be fit to is Belsil ^DMC 6038, because it can provide the highly transparent composite preparation, reach higher consumer's acceptability.The hydrophilic polysiloxanes that uses also can be from the ABIL EM 97 of Degussa/Goldschmidt.According to the present invention, also can use any mixture of particular silicone.

The hydrophilically modified polysiloxanes or the content of alcohol mixture are 0.5-10wt% based on composition total weight in described compositions, and preferred 1-8wt% is preferably 2-6wt% especially.

The present composition also can comprise emulsifying agent and/or surfactant.In a special preferred implementation, these are that the oxirane of 10-40mol is at the straight chain of 16-22 carbon atom or the addition compound product on the branched fatty alcohol, at the addition compound product that has on the 12-22 fatty acid, addition compound product on fatty acid alkanol amides, addition compound product on the fatty acid monoglyceride, addition compound product on the sorbitan fatty-acid monoester, addition compound product on fatty acid alkanol amides, addition compound product on fatty glyceride, the addition compound product on castor oil hydrogenated for example, addition compound product on the methyl glucosamine mono fatty acid ester and its mixture.Yet in principle, can use any other emulsifying agent and/or surfactant.

Say that on this meaning operable emulsifying agent for example is according to the present invention:

The oxirane of-4-30mol and/or the expoxy propane of 0-5mol are at straight chain or side chain C ₈-C ₂₂On the aliphatic alcohol, at C ₁₂-C ₂₂On the fatty acid and at C ₈-C ₁₅Addition compound product on the alkyl phenol,

The oxirane of-1-30mol is at C ₃-C ₆The C of the addition compound product on the polyhydric alcohol, particularly glycerol ₁₂-C ₂₂Fatty-acid monoester and diester,

-oxirane and polyglycereol be at the methyl glucosamine fatty acid ester, the addition compound product on fatty acid alkanol amides and the fatty acid glycosamine,

-C ₈-C ₂₂Alkyl list glycosides and oligomeric glycoside and its ethoxylation analog, wherein the oligomerisation degree is 1.1-5, is in particular 1.2-2.0, glucose is preferred as sugared component,

The mixture of-alkyl (oligomeric) glucosides and aliphatic alcohol for example can the commercial Montanov that obtains ^68,

The addition compound product of the oxirane of-5-60mol on Oleum Ricini and castor oil hydrogenated,

-have the polyhydric alcohol of 3-6 carbon atom and a saturated C ₈-C ₂₂The partial ester of fatty acid,

-sterol.Sterol is interpreted as and is meant steroid, uploads hydroxylly at the 3rd carbon atom of steroid main chain, perhaps separates from animal tissue's (zoosterol) or plant cream (phytosterol).The example of zoosterol is cholesterol and lanosterol.The example of suitable phytosterol is a cupreol, stigmasterol, campesterol and ergosterol.Sterol can be separated from fungus and yeast equally, so-called mycosterol.

-phospholipid mainly is glucose phospholipid, for example for example from egg yolk or plant seed (for example Semen sojae atricolor), obtains as lecithin or cholinphospholipide,

-sugar and sugar alcohol, Sorbitol for example, fatty acid ester,

-polyglycereol and polyglycereol derivant, preferred polyglyceryl-2 dimerization hydroxy stearic acid ester (commodity Dehymuls ^PGPH) and polyglyceryl-3 diisopstearate (commodity Lameform ^TGI),

-straight chain and side chain C ₈-C ₃₀Fatty acid and their sodium, potassium, ammonium, calcium, magnesium and zinc salt.

The present composition comprises the emulsifying agent that preferred content is 0.1-25wt%, particularly 0.5-15wt% based on total composition.

In in addition same preferred implementation, contain at least a be selected from anionic, zwitterionic, the ionic emulsifying agent of amphoteric and cationic emulsifier.The preferred anionic surfactants emulsifying agent is an alkyl sulfate, in molecule, contain up to 12 ethylene glycol ether groups and in alkyl, have the alkyl polyglycol ether sulfate and the ether carboxylic acid of 10-18 carbon atom, the sulfo-succinic acid list and the dialkyl that in alkyl, have 8-18 carbon atom, have 1-6 ethyoxyl and reach the sulfo-succinic acid monoalkyl polyoxy ethyl ester that in alkyl, has 8-18 carbon atom, monoglyceride sulfate, alkyl and alkenyl ether phosphate, and protein fatty acid condensation product.At least a quaternary ammonium group of zwitterionic emulsifying agent carrier band in molecule and at least a-COO ^-Perhaps-SO ₃ ^-Group.Suitable especially zwitterionic emulsifying agent is so-called betanin; N-alkyl-N for example; N-Dimethyl Ammonium glycine; N-acyl amino propyl group-N; N-Dimethyl Ammonium glycine; with 2-alkyl-3-carboxymethyl-3-hydroxyethyl imidazole quinoline, in described alkyl or acyl group, containing 8-18 carbon atom and cocoyl acyl amino ethyl-hydroxyethyl carboxymethylamino acetic acid under each situation.

Except C ₈-C ₂₄Alkyl or acyl group, amphoteric emulsifying agent in molecule, also comprise at least a free amino group and at least a-COOH or-SO ₃The H group can form inner salt.The example of suitable amphoteric emulsifier is a N-alkyl glycine; the N-alkyl aminopropionic acid; N-alkyl amino butanoic acid; N-alkyl imino dipropionic acid, N-ethoxy-N-alkyl amino propyl group glycine, N-alkyl taurine; N-alkyl sarcosine; 2-alkyl aminopropionic acid, and p dialkylaminobenzoic acid have about 8-24 carbon atom in described alkyl under each situation.

Described ionic emulsifying agent is 0.01-5wt% based on the content of total composition, is preferably 0.05-3wt%, particularly preferably is to be 0.1-1wt%.

Operable nonionic surfactant for example is according to the present invention:

-general formula is R ¹CO (OCH ₂CHR ²) _xOR ³The alkoxylated fatty acid Arrcostab, R wherein ¹CO is straight chain or the side chain with 6-22 carbon atom, saturated and/or unsaturated acyl group, R ²Be hydrogen or methyl, R ³Be straight chain or the branched alkyl with 1-4 carbon atom, x is 1-20,

The addition compound product of-oxirane on fatty acid alkanol amides and aliphatic amine,

-fatty acid N-alkyl glucose amide,

-C ₈-C ₂₂The alkyl amine n-oxide,

-be equivalent to general formula R O-(Z) _xAlkylpolyglycosides, wherein R is C ₈-C ₁₆Alkyl, Z are sugar, and x is the quantity of sugar unit.Operable alkylpolyglycosides can comprise only a kind of concrete alkyl R according to the present invention.Yet these chemical compounds are usually from natural fat and oil or mineral oil preparation.In this case, the alkyl R of existence is corresponding starting compound, the mixture after perhaps corresponding these chemical compound particular procedure.Preferred especially those alkylpolyglycosides, wherein R is basically by C ₈And C ₁₀Alkyl is formed, basically by C ₁₂And C ₁₄Alkyl is formed, basically by C ₈To C ₁₆Alkyl is formed, perhaps basically by C ₁₂To C ₁₆Alkyl is formed.

Any list or oligosaccharide can be used as sugared construction unit Z.Usually, use sugar and corresponding oligosaccharide, for example glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose with 5 or 6 carbon atoms.Preferred sugared construction unit is a glucose, fructose, galactose, arabinose, and sucrose; Glucose is particularly preferred.Operable alkylpolyglycosides comprises 1.1-5 on an average according to the present invention, preferred 1.1-2.0, preferred especially 1.1-1.8 sugar unit.Also can use the alkoxylate homologue of described alkylpolyglycosides according to the present invention.Each alkyl polyglucoside unit of these homologues can comprise on an average up to 10 oxirane and/or propylene oxide units.

Suitable zwitterionic surfactant is at least one quaternary ammonium group of carrier band and at least one in described molecule-COO ^(-)Perhaps-SO ₃ ^(-)The surface active cpd of group.Suitable especially zwitterionic surfactant is so-called betanin; N-alkyl-N for example; N-Dimethyl Ammonium glycine; cocoyl alkyl dimethyl glycine ammonium for example, N-acyl amino propyl group-N, N-Dimethyl Ammonium glycine; cocoyl aminopropyl dimethylglycine ammonium for example; with 2-alkyl-3-carboxymethyl-3-hydroxyethyl imidazole quinoline, in described alkyl or acyl group, have 8-18 carbon atom under each situation, and cocoyl amino-ethyl hydroxyethyl-carboxymethyl glycine.Preferred zwitterionic surfactant is the known fatty acid amide derivant that the INCI name is called cocoyl aminopropyl betanin.

Suitable anion surfactant is all anionic surface active substances that are suitable on the human body in the thing combined according to the invention.These surfactants are characterised in that the anion radical of solubilising, carbonyl acidic group, sulfate radical, sulfonic group, perhaps phosphate radical and have the lipophilic alkyl of about 8-30 carbon atom.In addition, in described molecule, can contain ethylene glycol or Polyethylene Glycol ether group, ester group, ether group and amide groups, and hydroxyl.Suitable foaming anion surfactant example is that form is the sodium that has 2-4 carbon atom in triacontanol group under each situation, potassium and ammonium, and single, the salt of two and three alkanol ammoniums.

The acyl glutamic acid of-general formula (II),

R wherein ¹CO is a straight chain or the chain acyl with 6-22 carbon atom and 0,1,2 or 3 two keys, and X is a hydrogen; alkali metal and/or alkaline-earth metal, ammonium, alkylammonium, alkanol ammonium or glucose ammonium; for example stem from and have 6-22, the fatty acid of preferred 12-18 carbon atom, for example C _12/14Perhaps C _12/18Coconut fatty acid, lauric acid, myristic acid, Palmic acid and/or stearic acyl glutamic acid, particularly N-cocoyl and N-stearyl L-sodium glutamate,

Two or tricarboxylic esters that the hydroxyl of-general formula (III) replaces,

X=H wherein, perhaps-CH ₂The COOR group, Y=H or-OH, condition is if X=-CH ₂COOR, Y=H then, R, R ¹And R ²Be hydrogen atom independently of one another, alkali metal or alkaline earth metal cation, ammonium group, the cation of ammonium organic base, or group Z, described group Z derives from polyhydroxylated organic compound, and described polyhydroxylated organic compound is selected from the (C of the etherificate with 1-6 monomer sugar unit ₆-C ₁₈) alkyl polysaccharide, and/or the aliphatic series (C with etherificate of 2-16 hydroxyl ₆-C ₁₆) the hydroxy alkyl polyol, condition is a radicals R, R ¹Perhaps R ²At least one be group Z,

The esters of the sulfosuccinate of-general formula (IV),

R wherein ¹And R ²Be hydrogen atom independently of one another, alkali metal or alkaline earth metal cation, ammonium group, ammonium-organic base cation, perhaps group Z, described group Z derives from polyhydroxylated organic compound, and described polyhydroxylated organic compound is selected from the (C of the etherificate with 1-6 monomer sugar unit ₆-C ₁₈) alkyl polysaccharide, and/or the aliphatic series (C with 2-16 hydroxyl etherificate ₆-C ₁₆) the hydroxy alkyl polyol, condition is a radicals R ¹Perhaps R ²At least one is group Z,

-in alkyl, have the sulfo-succinic acid list and the dialkyl of 8-24 carbon atom and have 1-6 ethyoxyl and in alkyl, have the sulfo-succinic acid monoalkyl polyoxy ethyl ester of 8-24 carbon atom,

The ester of-tartaric acid and citric acid and alcohol, its oxirane and/or expoxy propane that constitutes about 2-15 molecule has 8-22 the addition compound product on the fat of carbon atom alcohol,

-have the straight chain and a branched chain fatty acid (soap) of 8-30 carbon atom,

-general formula R-O-(CH ₂-CH ₂O) _x-CH ₂The ether carboxylic acid of-COOH, wherein R is the straight chained alkyl with 8-30 carbon atom, x=0 or 1-16,

-contain the straight chain with the two keys of 6-22 carbon atom and 0,1,2 or 3 or the acyl sarcosinates of a chain acyl,

-contain the straight chain with the two keys of 6-22 carbon atom and 0,1,2 or 3 or the acyl taurine salt of a chain acyl,

-contain the straight chain with the two keys of 6-22 carbon atom and 0,1,2 or 3 or the acyl-hydroxyethyl sulfonate of a chain acyl,

-have a straight chain paraffin sulfonate of 8-24 carbon atom,

-have the linear alpha-olefin sulfonate of 8-24 carbon atom,

-have an alpha-sulfo fatty acid methyl ester of 8-30 carbon atom fatty acid,

-general formula R-O (CH ₂-CH ₂O) _z-SO ₃The alkyl sulfate of X and alkyl polyglycol ether sulfate, wherein R preferably has the straight chained alkyl of 8-30 carbon atom, especially preferably has 8-18 carbon atom, z=0 or 1-12, preferred especially 3, X is a sodium, potassium, magnesium, zinc, ammonium ion or, the single alkanol that in triacontanol group, has 2-4 carbon atom, dialkanol or three alkanol ammonium ions, wherein more preferred example is the cocoyl ether zinc sulfate of ethoxylation degree z=3

-according to the mixture of the surface-active hydroxy sulfonate of DE-A-37 25 030,

-disclosed Sulfated hydroxyalkyl polyethylene and/or hydroxy alkylidene propylene glycol in DE-A-37 23 354,

-disclosed sulphonic acid ester in DE-A-39 26 344 with unsaturated fatty acid of 8-24 carbon atom and 1-6 two keys,

-general formula (alkyl v) and/or alkenyl ether phosphate,

-R wherein ¹The aliphatic hydrocarbon that preferably has 8-30 carbon atom, R ²Be hydrogen, group (CH ₂CH ₂O) _nR ¹Perhaps X, n is 1-10, X is a hydrogen, alkali metal or alkaline-earth metal or NR ³R ⁴R ⁵R ⁶, R wherein ³-R ⁶Be C independently of one another ₁-C ₄Alkyl,

-as disclosed among the DE-A 197 36 906.5, general formula is R ⁷CO (AlkO) _nSO ₃The sulphation fatty acid alkylene glycol ester of M, wherein R ⁷CO is straight chain or the side chain with 6-22 carbon atom, aliphatic series, and saturated and/or unsaturated acyl group, Alk is CH ₂CH ₂, CHCH ₃CH ₂And/or CH ₂CHCH ₃, n is 0.5-5, M is a cation,

The monoglyceride sulfate of-general formula (VI) and monoglyceride ether sulfate,

-R wherein ⁸CO is straight chain or the chain acyl with 6-22 carbon atom, x, 6 and z add up to 0 or 1-30, preferred 2-10, X is alkali metal or alkaline-earth metal.The representative instance that is applicable to monoglyceride (ether) sulfate of the object of the invention is the lauric acid monoglyceride, the cocoa fat acid monoglyceride, the Palmic acid monoglyceride, the stearic acid monoglyceride, oleic acid monoglyceride and tallow fatty acid monoglyceride and its ethylene oxide adduct and form are the product of the sulfur trioxide or the chlorosulfonic acid of their sodium salts.The preferred monoglyceride sulfate that uses general formula (VI), wherein R ⁸CO is the straight chain acyl group with 8-18 carbon atom.

In addition, the present composition can comprise at least a protein hydrolysate or its derivant.According to the present invention, can use or plant or animal protein hydrolyzate.The animal protein hydrolyzate for example is an elastin laminin, collagen, and keratin, silk and milk protein hydrolyzate, they also can be the forms of salt.According to the present invention, preferred plant protein hydrolysate, for example Semen sojae atricolor, Semen Tritici aestivi, Semen Armeniacae Amarum, Semen Pisi sativi, Rhizoma Solani tuber osi and rice protein hydrolyzate.Corresponding commodity for example are DiaMin ^(Diamalt), Gluadin ^(Cognis), Lexein ^(Inolex) and Crotein ^(Croda).

Replace described protein hydrolysate, can at first use the ispol that obtains by other method, secondly also can use the single aminoacid salt compatible with its physiology.Preferred amino acids comprises glycine according to the present invention, serine, threonine, cysteine, asparagine, glutamine, pyroglutamic acid, alanine, valine, leucine, isoleucine, proline, tryptophan, phenylalanine, methionine, aspartic acid, glutamic acid, lysine, arginine and histidine and described amino acid whose zinc salt and acid-addition salts.

The same possible derivant that is to use protein hydrolysate, for example form is their fatty acid condensation product.Corresponding commodity for example are Lamepon ^(Cognis), Gluadin ^(Cognis), Lexein ^(Inolex), Crolastin ^Perhaps Crotein ^(Croda).

According to the present invention, also can use the protein hydrolysate of cationization, wherein Ji Chu protein hydrolysate can derive from animal, plant, marine organisms form or derive from the protein hydrolysate that Biotechnology obtains.Preferred cationic protein hydrolysate, the molecular weight of its basic protein fractions are 100-25000 dalton, preferred 250-5000 dalton.And the cationic protein hydrolyzate is interpreted as and is meant quaternized aminoacid and its mixture.In addition, described cationic protein hydrolyzate also can further be derived again.The cationic protein hydrolyzate used according to the invention and the representative instance of derivant can be at " InternationalCosmetic Ingredient Dictionary and Handbook ", (seventh edition 1997, The Cosmetic, Toiletry, and Fragrance Association 1101 17th Street, N.W., Suite 300, Washington, DC 20036-4702) those that under the INCI name, mention in.With can the commercial product that obtains: the collagen of cocoyl dimethyl quaternary ammonium hydroxypropyl hydrolysis, the casein of cocoyl dimethyl quaternary ammonium hydroxypropyl hydrolysis, the collagen of stearyl leptodactyline hydroxypropyl hydrolysis, the hair-keratin of stearyl leptodactyline hydroxypropyl hydrolysis, the keratin of lauryl dimethyl ammonium salt hydroxypropyl hydrolysis, the rice protein of cocoyl dimethyl quaternary ammonium hydroxypropyl hydrolysis, the silk of cocoyl dimethyl quaternary ammonium hydroxypropyl hydrolysis, the soybean protein of cocoyl dimethyl quaternary ammonium hydroxypropyl hydrolysis, the wheat protein of cocoyl dimethyl quaternary ammonium hydroxypropyl hydrolysis, cocoyl dimethyl quaternary ammonium hydroxypropyl Silk Amino Acids, hydroxypropyl arginine lauryl/myristyl ether HCI, Hydroxyproyl Trimethyl ammonium salt gel.Very particularly preferably based on cationic protein hydrolyzate and the derivant of plant.

In the present composition, based on total composition, the content of described its protein hydrolysate and derivant or its aminoacid and derivant is for reaching 10wt%.Content is that 0.1-5wt%, particularly 0.1-3wt% are particularly preferred.

In addition, the present composition can comprise at least a list, oligomeric or polysaccharide or its derivant.

Suitable monosaccharide for example is glucose according to the present invention, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose and talose, deoxysaccharide trehalose and rhamnose, and amino sugar, for example glycosamine or chondrosamine.Preferred glucose, fructose, galactose, arabinose and trehalose; Glucose is particularly preferred.

The suitable oligosaccharide of the present invention is by two kinds to ten kinds monosaccharide units, sucrose for example, and lactose or trehalose are formed.Particularly preferred oligosaccharide is a sucrose.Using Mel, mainly comprise dextrose plus saccharose, is particularly preferred equally.

The suitable polysaccharide of the present invention is by forming greater than ten monosaccharide units.Starch and starch degradation product that preferred polysaccharide is made up of the alpha-D-glucose monomer, for example amylase, amylopectin and dextrin.Special advantage is chemistry and/or heat modification starch according to the present invention, hydroxypropyl starch phosphate ester for example, dihydroxypropyl PASELLI EASYGEL or commodity Dry Flo ^Preferred in addition dextran and their derivant, for example dextran sulfate.Equally preferably non-ionic cellulose derivative, methylcellulose for example, hydroxypropyl cellulose or hydroxyethyl-cellulose and cationic cellulose derivative, for example commodity Celquat ^With Polymer JR ^, preferred Celquat ^H 100, Celquat ^L 200 and Polymer JR ^400 (polyquaternary ammonium salt-10) and polyquaternary ammonium salt-24.Preferred in addition example is the unitary polysaccharide of trehalose, for example commodity Fucogel ^Especially preferably the polysaccharide, particularly chitin that constitutes from the amino sugar unit and they takes off acetyl derivative, chitosan, and mucopolysaccharide.Preferred mucopolysaccharide comprises hyaluronic acid and its derivant according to the present invention, for example hyaluronate sodium or dimethyl-silicon alkanol hyaluronate sodium and chrondroitin and its derivant, for example chondroitin sulfate.

In a favourable embodiment, compositions of the present invention comprises at least a film forming, stable emulsion, thickening or the polymer of the natural and synthetic polymer of being selected from of stickiness is arranged, and can be cationic, anionic, and both sexes are charged or non-ionic.According to the present invention, preferred cationic, anionic and non-ionic polymer.

In described cationic polymer, preferably contain the polysiloxanes of quaternary groups, commodity Q2-7224 (Dow Corning) for example, Dow Corning ^929emulsion (containing poly dimethyl silica amine), SM-2059 (General Electric), SLM-55067 (Wacker), and Abil ^-Quat3270 and 3272 (Goldschmidt).

Help the preferred anionic polymer of the active component effect used to comprise carboxylate and/or sulfonate ester group according to the present invention and as monomeric for example acrylic acid, methacrylic acid .beta.-methylacrylic acid, maleic anhydride and 2-acrylamide-2-methyl propane sulfonic acid.Among the present invention, acidic-group can global existence, perhaps as sodium, and potassium, ammonium, list or tri ethanol ammonium salt partly exist.Preferred monomer is 2-acrylamide-2-methyl propane sulfonic acid and acrylic acid.Anionic polymer very particularly preferably comprises, and as only monomer or as the 2-acrylamide-2-methyl propane sulfonic acid of comonomer, wherein said sulfonic group can global existence or partly existed with salt form.Within this embodiment, preferably use the copolymer of at least a anionic monomer and at least a non-ionic monomer.As for anionic monomer, referring to material listed above.Preferred nonionic monomer is an acrylamide, Methacrylamide, acrylate, methacrylate, vinyl pyrrolidone, vinyl Ether and vinyl esters.The preferred anionic surfactants copolymer is an acrylic acid-acrylamide copolymer, particularly contains the monomeric polyacrylamide copolymer of sulfonic group.A particularly preferred anionic copolymer is made up of the acrylamide of 70-55mol% and 2-acrylamide-2-methyl propane sulfonic acid of 30-45mol%, and wherein said sulfonic group is with global existence or as sodium, potassium, and ammonium, list or tri ethanol ammonium salt partly exist.This copolymer also can be crosslinked form exist, and in such cases, the preferably poly-ethylenically unsaturated compounds of the cross-linking agent of use, tetraene propoxyl group ethane for example, allyl sucrose, pi-allyl tetramethylolmethane and methylene-bisacrylamide.A kind of such polymer is present in the commodity Sepigel of SEPPIC ^305.In the scope of the present invention's instruction, use this chemical compound to prove particularly advantageous.According to the present invention, with title Simulgel ^600 sodium acryloyldimethyl taurate copolymers of selling as the chemical compound that contains 2-Methylpentadecane and polysorbate-80, also prove effective especially.

Preferred anionic surfactants homopolymer and copolymer are uncrosslinked and crosslinked polyacrylic acid in addition.Among the present invention, tetramethylolmethane, the allyl ether of sucrose and propylene can be a preferred cross-linking agents.Such chemical compound for example is commodity Carbopol ^Particularly preferred anionic copolymer comprises, and is unsaturated as monomeric 80-98%, (if hope) C of replacement _3-6(if hope) saturated C that carboxylic acid or its anhydride and 2-20 replace _10-30The acrylate of carboxylic acid, wherein said copolymer can be crosslinked with above-mentioned cross-linking agent.Corresponding commodity are Pemulen  and Carbopol  label 954,980,1342 and ETD 2020 (ex B.F.Goodrich).

Suitable non-ionic polymers for example is a polyvinyl alcohol, can be partly-hydrolysed, and commodity Mowiol for example ^And vinyl pyrrolidone/vinyl ester copolymer and polyvinylpyrrolidone, for example with trade name Luviskol ^(BASF) sell.

The present composition also can comprise at least a alpha-hydroxy carboxylic acid compounds or α-keto-carboxylic acid or its ester, the form of lactone or salt.Suitable α-keto-carboxylic acid is selected from lactic acid, tartaric acid, citric acid, the 2-hydroxybutyric acid, 2, the 3-dihydroxypropionic acid, the 2-hydroxypentanoic acid, 2-hydroxycaproic acid, 2-hydroxyl enanthic acid, the 2-Hydroxycaprylic acid, 2-hydroxydecanoic acid, 2-hydroxyl lauric acid, 2-hydroxyl ten tetra-carbonics, the acid of 2-hydroxy-16 carbon, 2-hydroxyl 18 carbonic acid, mandelic acid, 4-hydroxymandelic acid, malic acid, erythraric acid, threaric acid, glucosaccharic acid, galactosaccharic acid, mannosaccharic acid (mannaric acid), Gularic acid, 2-hydroxy-2-methyl succinic acid, gluconic acid, acetone acid, glucuronic acid and galacturonic acid.The esters of described acid is selected from methyl, ethyl, propyl group, isopropyl, butyl, pentyl, amyl group, hexyl, 2-ethylhexyl, octyl group, decyl, dodecyl and cetyl esters.The content of described alpha-hydroxy carboxylic acid compounds or α-keto-carboxylic acid or their derivant is 0.1-10wt% based on total composition under each situation, preferred 0.5-5wt%.

Compositions of the present invention can comprise other active component, adjuvant and additive, for example:

-be selected from A, C, the vitamin of E and F family, rovitamin and previtamin thing, particularly 3, the two dehydroretinol (vitamin A of 4- ₂), β-phylloerythrin (vitamin A ₁Rovitamin), ascorbic acid (vitamin C) and Palmic acid esters, glucosides, perhaps ascorbic acid phosphate, tocopherol, particularly alpha-tocopherol and its esters, acetas for example, nicotinate, phosphate ester and succinate; Be vitaminF equally, be interpreted as to be meant essential fatty acid, linoleic acid specifically, linolenic acid and arachidonic acid;

-retinol (vitamin A ₁) and C _2-18The ester of carboxylic acid, particularly retinyl acetate or retinyl palmitate,

The vitamin of-vitamin B complex, rovitamin or previtamin thing, perhaps its derivant and derivant 2-furanone, particularly vitamin B ₁(thiamine vitamin B ₁), vitamin B ₂(riboflavin), vitamin B ₃(nicotinic acid and/or nicotiamide), vitamin B ₅(pantothenic acid and/or pantothenylol), vitamin B ₆(pyridoxol, vitamin B ₆Amine and/or 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine .) and/or vitamin B ₇(biotin),

-allantoin,

-antioxidant, for example imidazoles (for example urocanic acid) and its derivant; peptide, D for example, L-carnosine; the D-carnosine, L-carnosine and its derivant (for example anserine), chlorogenic acid and its derivant; thioctic acid and its derivant (for example dihydrolipoic acid), aurothioglucose, propylthiouracil and other mercaptan (thioredoxin for example; glutathion; cysteine, cystine, cystamine and glycosyl; the N-acetyl group; methyl, ethyl, propyl group; pentyl; butyl, and lauryl, hexadecanoyl; oleyl; γ-Ya oil base, cholesteryl and its glyceride); with its salt; dilauryl thiodipropionate, distearyl thiodipropionate, thio-2 acid and its derivant (esters; ether; peptide, lipid, nucleotide; nucleoside and salt); the sulfo group oxime compound of extremely low tolerance (for example pmol is to μ mol/ kilogram) (butyl thionine imines for example, homocysteine sulfo group oxime, butyl thionine sulfone; penta; oneself, heptyl thionine imines), same is (metal) chelating agen (alpha-hydroxy fatty acid for example; Palmic acid; phytic acid, lactotransferrin), humic acid; bile acid; bile extract, bilirubin, biliverdin; ethylenediaminetetraacetic acid; EGTA ethylene glycol bistetraacetic acid and its derivant, unsaturated fatty acid and its derivant (gamma-Linolenic acid for example; linoleic acid; oleic acid), folic acid and its derivant, ubiquinone and pantothenylol and its derivant; the coniferyl benzoate of benzoin resin; rutinic acid and its derivant, alpha-glycosyl rutin, ferulic acid; the furfurylidene glucitol; carnosine, butylated hydroxytoluene, butylhydroxy anethole; nordihydroguaiacic acid; nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivant; catalase; superoxide dismutase, zinc and its derivant (zinc oxide for example, ZnSO ₄), selenium and its derivant (for example selenomethionine), stilbene and its derivant (for example stilbene oxide, trans stilbene oxide) and these suitable derivants (salt, ester, ether, sugar, nucleotide, nucleoside, peptide and lipid) as the antioxidant activity composition,

-N-fatty acyl group sphingosine and false vitalility be through amide,

-triterpene, particularly triterpenic acid (triterpenoic acids), ursolic acid for example, rosmarinic acid (rosmaric acid), belulinic acid Betulinic acid, boswellic acid and bryonolic acid,

-monomeric catechuic acid, specifically catechuic acid and epicatechin, leucoanthocyanidin, catechuic acid polymer (cachou extract tannin), and gallotannin,

-thickening agent, example gel, plant gum, for example bengal gelatine, guar gum, alginic acid fat, xanthan gum, Radix Acaciae senegalis, karaya, perhaps carob flour, natural and synthesis of clay and phyllosilicate, Bentonite for example, Strese Hofmann's hectorite., montorillonite clay, perhaps LAPONITE , complete synthetic hydrocolloid, for example polyvinyl alcohol, and the calcium of fatty acid, the soap of magnesium or zinc

-plant glycoside,

-structural agent, for example maleic acid and lactic acid,

-dimethyl isosorbite,

-α-, β-and γ-cyclodextrin, be used in particular for stablizing retinol,

-solvent, swelling and permeate substance, ethanol for example, isopropyl alcohol, ethylene glycol, propylene glycol, dihydroxypropane single-ether, glycerol and diethylene glycol, carbonate, bicarbonate, guanidine, phosphoamide and replaces, and two replace and three replacement phosphate,

-aromatic oil is used for the pigment and the dyestuff of coloured composition,

-be used to regulate the material of pH, α-and beta-hydroxycarboxylic acids,

-chelating agent, ethylenediaminetetraacetic acid for example, nitrilotriacetic acid(NTA), Beta-alanine oxalic acid and phosphonic acids,

-opacifier, emulsion for example, styrene/polyvinyl pyrrolidone and styrene/acrylamide copolymer,

-pearling agent, for example monostearate and diglycol stearate and PEG-3 distearate,

-propellant, propane/butane mix for example, N ₂O, dimethyl ether, CO ₂And air,

-MMP-1-inhibitor particularly is selected from light cracking enzyme and/or T4 endonuclease V, PG, precocene, 6-hydroxyl-7-methoxyl group-2,2-dimethyl-1 (2H)-.alpha.-5:6-benzopyran and 3,4-dihydro-6-hydroxyl-7-methoxyl group-2,2-dimethyl-1 (2H)-.alpha.-5:6-benzopyran

-organically, inorganic photoprotection filter inorganic and/or modification, particularly UVA filter, and/or UVB filter.

In a preferred implementation, the present composition comprises at least a anti-perspirant active component.Suitable anti-perspirant active component is the astringent of water soluble according to the present invention, perhaps condenses proteinic metallic salt, particularly aluminum, zirconium, the inorganic and organic salt of zinc and titanium and any mixture of these salt.According to the present invention, dissolubility is interpreted as and is meant at 20 ℃ of every 100g solution and dissolves 4g active substance at least in the water.According to the present invention, can use for example Alumen (KAl (SO ₄) ₂12H ₂O), aluminum sulfate, aluctyl., chlorine hydroxyl aluctyl. sodium, chlorine hydroxyl aldioxa (chlorohydroxyallantoinate aluminum), aluminium chlorohydrate, aluminum phenolsulfonate, the aluminium chlorohydrate zirconium, zinc chloride, zinc sulfocarbolate, zinc sulfate, chloro hydrous zirconium oxide(HZO), aluminium chlorohydrate zirconium glycine complexes and the aluminum chloride of alkalescence and the complex of propylene glycol or Polyethylene Glycol.Described liquid actives preparation preferably comprises astringent aluminum salt, particularly aluminium chlorohydrate, and/or the aluminum zirconium compounds.Aluminium chlorohydrate for example with powder type as Micro Dry ^Ultrafine, perhaps activated form is as the Reach of Reheis ^501 or Reach ^103 sell, and with the Locron of aqueous solution form as Clariant ^L or as the Chlorhydrol of Reheis ^Sell.The sesquialter aluminium chlorohydrate is with title Reach ^301 are provided by Reheis.According to the present invention, for example use the name that obtains by Reheis to be called Rezal ^The coordination compound of the hydration three of G or tetrachloro ten trihydroxies or ten dihydroxy aluminum zirconiums and glycine is particularly advantageous equally.

The content of the anti-perspirant active component that contains in the present composition is 0.01-40wt% based on the amount of active substance in the total composition, and preferred 2-30wt% is in particular 5-25wt%.

In in addition special preferred implementation, the present composition also comprises at least a other deodorizer active component except that the material that contains prebiotic effect.Suitable deodorizer active component is an essence in addition according to the present invention, antimicrobial drug, antimicrobial or germicidal material, enzyme inhibitor, antioxidant and stink adsorbent.

Particularly, organohalogen compound and organohalogen compounds, quaternary ammonium compound and zinc compound are suitable.Preferred chlorhexidine and chlorhexidine gluconate, zephiran halogenide and cetylpyridinium chloride(CPC).Can use sodium bicarbonate equally, sodium sulfocarbolate., and zinc phenolsulfonate, the composition of linden flower oil and chamomile oil, bisabolol, phenyl phenol, triclosan (Irgasan ^DP 300) or triethyl citrate.

As enzyme inhibitor, preferably relate to the inhibitor of the enzyme of the axillary fossa microorganism species that forms body odor.These are lipase preferably, aryl sulfatase (seeing WO 01/99376), β-glucose hyaluronidase (seeing WO 03/039505), the inhibitor of 5-5 alpha-reductases and amino acylase.

Antibiotic effective deodorizer active component in addition is a lantibiotics; the sweet cream of glycosyl; sphingolipid (N-fatty acyl group sphingosine); sterol and other inhibition are adhered to the active component of the antibacterial of skin, glycosidase for example, lipase; proteinase; carbohydrate, two and oligosaccharide fatty acid ester and alkylation list and oligosaccharide.

The suitable in addition active component as deodorizer is the polyol of water soluble, is selected from the glycol of water soluble, three pure and mild polyhydric alcohol, and Polyethylene Glycol.In described glycol, C ₂-C ₁₂Glycol is suitable, particularly 1, and 2-propylene glycol, butanediol, for example 1,2-butanediol, 1,3 butylene glycol and 1,4-butanediol, pentanediol, for example 1,2-pentanediol, and hexanediol, l for example, 6-hexanediol.Same preferred suitable be glycerol and technical grade be the oligomeric glycerol mixture of 1.5-10 from condensation degree, for example the diglycerol content of technical grade is the diglycerol mixture of 40-50wt%, perhaps triglycerin, and 1,2,6-hexanetriol and mean molecule quantity are the daltonian Polyethylene Glycol of 100-1000 (PEG), for example PEG-400, PEG-600 or PEG-1000.Suitable in addition polyhydric alcohol is C ₄-, C ₅-and C ₆-monosaccharide and corresponding sugar alcohol, for example mannitol or Sorbitol.

Based on anhydrous wax with based on water-in-oil emulsion and oil-in-water emulsion, deodorizer or bar-shaped antiperspirant also can be gel forms.The gelinite club can be based on fatty acid soaps, dibenzylidene sorbitol, N-acyl amino-acid amide, 12-hydroxy stearic acid and the preparation of other gelinite forming agents.Aerosol spray, pump sprays, rolling the application scenario of putting formula container dress deodorizer on the skin and emulsifiable paste can water-in-oil emulsion, oil-in-water emulsion, water bag silicone oil emulsion, water-in-oil microemulsion, the oil-in-water micro emulsion, water bag silicone oil micro emulsion, no water slurry, the solution that contains alcohol and water alcohol, aqueous gel and oil exist.All specific compositionss can be for example based on can be through the fatty acid soaps of chemistry and/or physical modification; dibenzylidene sorbitol, N-acyl amino-acid amide, 12-hydroxy stearic acid; the polyacrylate of carbomer and carbopol type, polyacrylamide and polysaccharide and thickening.Described emulsion and micro emulsion can be transparent, and be limpid or opaque.

The compositions that liquid of the present invention and gel give form can comprise thickening agent, cellulose ether for example, hydroxypropyl cellulose for example, hydroxyethyl-cellulose and methylhydroxypropylcellulose, thickening polymer based on polyacrylate, if it can be crosslinked that described polyacrylate is wished, for example carbopol label or Pemulen ^Product is perhaps based on polyacrylamide or contain sulfonic polyacrylate, for example Sepigel ^305 or Simulgel ^EG also can be inorganic thickening agent, for example bentonite and Strese Hofmann's hectorite. (Laponite ^).

Compositions of the present invention can comprise the active component that beauty treatment is used and skin is used in addition, and for example the material of antiinflammatory is selected from Silicon stone, Aerosil  label for example, silica gel, silicon dioxide, clay, for example bentonite or Kaolin, Magnesiumaluminumsilicate, Talcum for example, boron nitride, the solid of titanium dioxide, if described solid is wished and can be applied, optional modified starch and starch derivatives, cellulose powder and polymer powder, and plant extract, protein hydrolysate, vitamin, aromatic oil, sebostatics, anti-acne active component and keratolytic.

The present composition if they exist with liquid state, then can be applied on the carrier of flexible and absorption, and can be used as deodorizer or anti-perspirant cloth or sponge and provide.The suitable flexible and absorption carrier that is used for the object of the invention for example is by textile fiber, the carrier that collagen or polymeric foam are made.Operable textile fiber or natural fiber, for example cellulose (cotton, linen), silk, Pilus Caprae seu Ovis, regenerated cellulose (viscose, artificial silk), cellulose derivative, or synthetic fibers, polyester for example, polyacrylonitrile, polyamide or polyolefine fiber, the mixture of fibrage perhaps like that or non-textile.Can these fibers of processed to obtain the absorbent cotton pad, pile fabric perhaps obtains braiding or knitted fabric.Flexible and adsorb polymeric foam, for example polyurethane foam and polyamide foam also are suitable base materials.Described base material can have one, two, three or greater than three the layer, wherein said monolayer can be made up of identical or different materials.Each substrate layer can have homogeneous or uneven structure, the zone that for example has different variable density.

For the object of the invention, the absorption carrier base material is considered to those at 20 ℃, based on dry weight, with absorption and/or capillary tube mode in conjunction with the base material of 10wt% water at least.Yet preferred appropriate carriers is those with absorption and the combination of the capillary tube mode carrier of 100wt% water at least.

By handling and/or the described adsorbent of surface treatment with the present composition, flexible carrier substrate, preferably by textile fiber, collagen or polymeric foam are made, described carrier substrate is processed at last, optionally drying they.In this, the processing of described carrier substrate (surface treatment) can be carried out by any method, for example the present composition is sprayed on the described carrier substrate, floods and is squeezed into, be immersed on the described carrier substrate, perhaps inject described carrier substrate simply.

Equally preferably as the aerocolloidal form that gives, the compositions of the usefulness of wherein improving looks comprises propellant, is preferably selected from propane according to the present invention, butane, iso-butane, pentane, 2-methybutane, dimethyl ether, fluorocarbon and Chlorofluorocarbons (CFCs).Can use the propellant of compression equally, for example air, nitrogen or carbon dioxide.Can use the mixture of described propellant equally.

In a preferred implementation, present composition form is liquid or solid-state oil-in-water emulsion, water-in-oil emulsion, polybasic emulsion, micro emulsion, PIT emulsion, perhaps Pickering emulsion, hydrogel, the fat gel, single-phase or multi-phase solution, foam, powder perhaps contains at least a mixture of polymers that is suitable as medicinal adhesive.Described compositions also can anhydrous form give with, for example oil or face cream.Among the present invention, described carrier can be plant or animal oil, mineral oil, artificial oil, the perhaps mixture of oil like that.

In special embodiment of the present composition, described composition forms is a micro emulsion.For the object of the invention, micro emulsion is interpreted as equally and is meant so-called " PIT " emulsion and thermodynamically stable micro emulsion.These emulsion are to contain 3 component water, and the system of oil and emulsifying agent at room temperature exists as oil-in-water emulsion.Once these systems of heating, within specific range of temperatures, (be called phase inversion temperature (PIT) or " PIT "), just form micro emulsion, just change Water-In-Oil (W/O) emulsion into once the described micro emulsion of further heating.Once with postcooling, just form O/W emulsion once more, although even at room temperature, their forms are micro emulsion, perhaps form is an emulsion very in small, broken bits, mean particle diameter is below 400 nanometers, in particular for about 100-300 nanometer.According to the present invention, preferably those mean particle diameters are micro emulsion or " PIT " emulsion of about 200 nanometers.Detailed description as for these " PIT emulsion " is for example seen publication Angew.Chem.97, among the 655-669 (1985).

Following examples are used for illustrating the present invention, and the present invention are not limited to this.

Embodiment

Example 1: under there is situation in plant extract, the influence of staphylococcus epidermidis and staphylococcus hominis growth

From the liquid pre-culture of staphylococcus epidermidis and staphylococcus hominis, inoculation optical density OD (600 nanometer) is the kind bacterium in 0.05 the LB medium.In parallel tester (not adding extractant or extracting solution), under each situation, handle 2 parts of cultures with 1% plant extract, within 30h, grow by writing down with reference to the OD measurement result.After 30h, determine to contain the difference between OD and the corresponding tester (not containing the extracting solution additive) of culture of extracting solution additive by proofreading and correct in the value of measuring under the situation that does not have cell (cells).The Ramulus et Folium Mussaendae Pubescentis of Shi Yonging (Camellia sinensis tea) selectively, carcade (Hibiscus), Radix Malvae sylvestris, Fructus Vitis viniferae, Semen Vitis viniferae, Radix Dauci Sativae/jojoba, the extract of myrrh and Calendula arvensis L. promotes the growth of staphylococcus epidermidis, suppresses the growth of staphylococcus hominis simultaneously.

Table 1: various plant extracts are to the influence (comparing promotion after 30h or inhibitive factor with tester) of staphylococcus epidermidis and staphylococcus hominis

	Ramulus et Folium Mussaendae Pubescentis	Carcade	Radix Malvae sylvestris	Fructus Vitis viniferae	Semen Vitis viniferae	Myrrh	Radix Dauci Sativae/jojoba	Calendula arvensis L.
									Staphylococcus epidermidis	1.18	1.67	1.56	1.19	1.38	1.47	1.10	1.43
Staphylococcus hominis	0.77	0.79	0.83	0.79	0.64	0.99	0.63	0.92

The Hibiscus extract (Carcade) of various preparation is to the growth effect of staphylococcus epidermidis and staphylococcus hominis

From the liquid pre-culture of staphylococcus epidermidis and staphylococcus hominis, inoculation optical density OD (600 nanometer) is the kind bacterium in 0.05 the LB medium.In parallel tester (not adding extractant or extracting solution), under each situation, handle 2 parts of cultures with 1% plant extract, within 30h, grow by writing down with reference to the OD measurement result.After 30h, determine to contain the difference between OD and the corresponding tester (not containing the extracting solution additive) of culture of extracting solution additive by proofreading and correct in the value of measuring under the situation that does not have cell (cells).Use various Hibiscus extracts from Cosmetochem, that is, " the herbasol extracting solution in 80%PG is the Carcade of preservation not " " Carcade (Hibiscus) herbasec " and " Carcade (Hibiscus) herbasol extraction oil-soluble ".

Table 2: the Hibiscus extract (Carcade) of various preparation is to the growth effect (comparing promotion after 24h or inhibitive factor with isopropyl myristate) of staphylococcus epidermidis and staphylococcus hominis

	Water/propylene glycol	Water/ethanol (on maltodextrin based carrier)	Isopropyl myristate
				Staphylococcus epidermidis	1.36	2.59	1.38
Staphylococcus hominis	1.00	1.00	1.01

Embodiment 3: the myristate derivant is to the growth effect of staphylococcus epidermidis and staphylococcus hominis

From the liquid pre-culture of staphylococcus epidermidis and staphylococcus hominis, inoculation optical density OD (600 nanometer) is the kind bacterium in 0.05 the LB medium.In parallel tester (not adding cell (cells) or myristate), under each situation, handle 2 parts of cultures with 1% myristate derivant, within 8h, grow by writing down with reference to the OD measurement result.After 8h, determine to contain the difference between OD and the corresponding tester (not containing the myristate additive) of culture of myristate additive by proofreading and correct in the value of measuring under the situation that does not have cell (cells).Isopropyl myristate and myristic acid ethyl ester are inhibited to staphylococcus hominis, and simultaneously staphylococcus epidermidis are had moderate facilitation.

Table 3: different myristate derivants is to the growth effect (promotion or the inhibitive factor compared with described tester) of staphylococcus epidermidis and staphylococcus hominis

	Isopropyl myristate	The myristic acid ethyl ester
			Staphylococcus epidermidis	1.24	1.44
Staphylococcus hominis	0.50	0.22

Embodiment 4: ethylhexyl glycerol (Sensiva SC50) is to the growth effect of staphylococcus epidermidis and staphylococcus hominis

From the liquid pre-culture of staphylococcus epidermidis and staphylococcus hominis, inoculation optical density OD (600 nanometer) is the kind bacterium in 0.05 the LB medium.[do not add cell (cells), perhaps ethylhexyl glycerol (Sensiva SC50, Sch ü lke ﹠amp at parallel tester; Mayr] in, under each situation, 2 parts of cultures of the ethylhexyl glycerin treatment with 0.1% are grown with reference to OD measurement result record within 24h.At 4h, after 8h and the 24h, determine to contain the difference between OD and the corresponding tester (not containing the extracting solution additive) of culture of ethylhexyl glycerol by proofreading and correct in the value of measuring under the situation that does not have cell (cells).Ethylhexyl glycerol suppresses staphylococcus hominis, and does not suppress staphylococcus epidermidis.

Table 4: between test period, ethylhexyl glycerol is to the growth effect (promotion of comparing with tester or inhibitive factor) of staphylococcus epidermidis and staphylococcus hominis

	4h	8h	24h
				Staphylococcus epidermidis	1.06	1.06	1.10
Staphylococcus hominis	0.87	0.92	0.76

Embodiment 5: comprise the influence of the deodorant formulations of Hibiscus extracting solution and antimicrobial drug component to staphylococcus epidermidis and staphylococcus hominis growth

From the overnight culture of staphylococcus epidermidis and staphylococcus hominis, preparation OD in 100ml LB medium ₆₀₀=0.1 (corresponding about 10 ⁴The mixture of cell/ml) is in advance to wherein adding the deodorant formulations that does not contain or contain 1wt% Hibiscus extracting solution that final concentration is 10% (v/v).Described culture is cultivated 48h altogether then under 37 ℃ and 100rpm.0 and 48h, determine micro organism quantity by plate culture.

Because the effective ingredient of described antibacterial has non-specific inhibition to all types of antibacterials, but give birth to influence, the overlapping synergistically reinforcement of described antimicrobial effect owing to contain the benefit of prebiotic effect material.

Therefore, be clear that very that from table 5 deodorant formulations that does not contain the Hibiscus extracting solution of use has approximate identical intensive depression effect to staphylococcus epidermidis and staphylococcus hominis.On the other hand, under the situation that contains Hibiscus extracting solution preparation, obviously have quite more weak inhibition, and have the intensive inhibition of continuing for staphylococcus hominis for staphylococcus epidermidis.

Table 5: contain and do not contain the contrast of the influence of Hibiscus extracting solution deodorant formulations

	Staphylococcus epidermidis		Staphylococcus hominis
					Time (h)	Not containing the art rose of Sharon belongs to	Contain Hibiscus	Do not contain Hibiscus	Contain Hibiscus
0	1.41E+04	1.41E+04	4.57E+04	4.57E+04
					48	7.00E+02	3.20E+03	1.00E+02	1.00E+02

The embodiment preparation

The anhydrous bar-shaped antiperspirant (data by weight) that contains surfactant

	1.1	1.2	1.3	1.4	1.5	1.6	1.7	1.8	1.9
										EutanolG16	10	-	-	15	10	-	10	-	10
CetiolOE	-	10	15	-	-	-	-	-	-
										Ucon FluidAP	5	5	5	5	5	5	5	5	5
CutinaHR	6	6	6	6	6	6	2	5	6
										LorolC18	20	20	20	-	20	20	-	-	20
LanetteO	-	-	-	20	-	-	10	12	-
										EumulginB3	3	3	3	3	3	3	3	3	-
CutinaE 24PF	-	-	-	-	5	-	-	-	-
										Aluminium chlorohydrate	20	20	20	20	20	20	20	-	-
Talcum	8	8	8	8	8	8	8	28	28
										Benefit is given birth to plant extract	0.4	0.6	0.8	1.0	1.2	-	-	-	0.4
SensivaSC50	-	-	-	-	-	0.4	0.8	-	-
										Isopropyl myristate	-	-	-	-	-	-	-	1.0	1.0
Silicone oil DC  245	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Sprayable limpid anti-perspirant micro emulsion (data are represented with wt%)

	2.1	2.2	2.3	2.4	2.5	2.6	2.7	2.8
									Plantaren1200	1.71	1.71	-	1.71	1.71	-	1.71	1.71
Plantaren2000	1.14	1.39	2.40	1.14	1.39	2.40	1.14	1.39
									Glycerin mono-fatty acid ester	0.71	0.71	-	0.71	0.71	-	0.71	0.71
Dioctyl ether	4.00	4.00	0.09	4.00	4.00	0.09	4.00	4.00
									Octyldodecanol	1.00	1.00	0.02	1.00	1.00	0.02	1.00	1.00
Aromatic oil	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
									Aluminium chlorohydrate	8.00	5.00	5.00	-	-	-	8.00	5.00
1, the 2-propylene glycol	5.00	5.00	-	5.00	5.00	-	5.00	5.00
									Glycerol	-	-	5.00	-	-	5.00	-	-
SensivaSC50	-	-	-	-	-	-	0.5	0.5
									Benefit is given birth to plant extract	0.2	0.4	0.6	0.8	1.0	1.2	-	0.5
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Soapy club (data are represented with wt%)

	3.1	3.2	3.3	3.4	3.5	3.6	3.7	3.8
									Ethanol	22.5	22.5	22.5	22.5	22.5	22.5	22.5	22.5
CutinaFS45	4.4	4.4	4.4	4.4	4.4	4.4	4.4	4.4
									1,3 butylene glycol	31.7	31.7	31.7	31.7	31.7	31.7	31.7	31.7
1, the 2-propylene glycol	21.0	21.0	21.0	21.0	21.0	21.0	21.0	21.0
									EutanolG	2.0	2.0	2.0	2.0	2.0	2.0	2.0	2.0
AethoxalB	3.0	3.0	3.0	3.0	3.0	3.0	3.0	3.0
									CremophorRH 455	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
NaOH 45% concentration	1.44	1.44	1.44	1.44	1.44	1.44	1.44	1.44
									Aromatic oil	2.0	2.0	2.0	2.0	2.0	2.0	2.0	2.0
Benefit is given birth to plant extract	0.2	0.4	0.6	0.8	1.0	-	-	-
									SensivaSC50	-	-	-	-	-	0.3	0.8	-
Isopropyl myristate	-	-	-	-	-	-	-	1.0
									Distilled water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Soapy deodorizer (data are represented with wt%)

	3.1	3.2	3.3	3.4	3.5	3.6	3.7	3.8
									Ethanol	22.5	22.5	22.5	22.5	22.5	22.5	22.5	22.5
CutinaFS45	4.4	4.4	4.4	4.4	4.4	4.4	4.4	4.4
									1,3 butylene glycol	31.7	31.7	31.7	31.7	31.7	31.7	31.7	31.7
1, the 2-propylene glycol	21.0	21.0	21.0	21.0	21.0	21.0	21.0	21.0
									EutanolG	2.0	2.0	2.0	2.0	2.0	2.0	2.0	2.0
AethoxalB	3.0	3.0	3.0	3.0	3.0	3.0	3.0	3.0
									CremophorRH 455	0.05	0.05	0.05	0.05	0.05	0.05	0.05	0.05
NaOH 45% concentration	1.44	1.44	1.44	1.44	1.44	1.44	1.44	1.44
									Phenoxyethanol	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
SensivaSC 50	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3
									Aromatic oil	2.0	2.0	2.0	2.0	2.0	2.0	2.0	2.0
Benefit is given birth to plant extract	0.1	0.3	0.5	0.8	1.0	0.5	-	-
									Isopropyl myristate	-	-	-	-	-	0.8	0.8	1.0
Distilled water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorizer in the pumping nebulizer (data are represented with wt%)

	4.1	4.2	4.3	4.4	4.5	4.6	4.7
								Ethanol, 96% concentration (DEP degeneration)	55.0	55.0	55.0	55.0	55.0	55.0	55.0
Triethyl citrate	3.0	3.0	3.0	3.0	3.0	3.0	3.0
								CremophorRH 455	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Benefit is given birth to plant extract	0.2	0.4	0.6	0.8	1.0	-	-
								SensivaSC50	-	-	-	-	-	0.4	0.6
Aromatic oil	1.0	1.0	1.0	1.0	1.0	1.0	1.0
								Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anhydrous deodorant spray (data are represented with wt%)

	6.1	6.2	6.3	6.4
					The 2-octadecanol	0.5	0.5	0.5	0.5
Ethanol, 99% concentration, (DEP degeneration)	39	39.45	39	39
					Benefit is given birth to plant extract	0.5	1.0	-	-
SensivaSC50	-	-	0.5	-
					Isopropyl myristate	-	-	-	1.0
Normal butane	60	60	60	60

Roll and put formula container dress anti-perspirant (data are represented with wt%) on the skin

	5.1	5.2	5.3	5.4	5.5
						Ethanol, 96% concentration (DEP degeneration)	30.0	30.0	30.0	30.0	30.0
MergitalCS11	2.0	2.0	2.0	2.0	2.0
						EumulginB3	2.0	2.0	2.0	2.0	2.0
Aluminium chlorohydrate	20.0	20.0	20.0	20.0	20.0
						Hydroxyethyl-cellulose	0.5	0.5	0.5	0.5	0.5
Benefit is given birth to plant extract	0.2	0.5	1.0	-	-
						SensivaSC 50	-	-	-	0.5	-
Isopropyl myristate	-	-	-	-	1.0
						Aromatic oil	0.8	0.8	0.8	0.8	0.8
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Floating type anti-perspirant spray (data are represented with wt%)

	6.1	6.2	6.3
				DC-245	10.0	10.0	10.0
Isopropyl myristate	5.0	5.0	5.0
				The aluminium chlorohydrate powder	5.0	5.0	5.0
AerosilR 972	2.0	2.0	2.0
				SensivaSC50	-	-	0.5
Benefit is given birth to plant extract	0.5	1.0	-
				Normal butane	Be added to 100	Be added to 100	Be added to 100

Clear antiperspirant gel (data are represented with wt%)

		8.1
			Phase 1	DC-245	7.0
	DC-3225	10.0
				Benefit is given birth to plant extract	1.0
Phase 2	Chlorhydrol	50.0
				1, the 2-propylene glycol	16.0
	Water	16.9

Under stirring state, will 2 within 25 minutes, join in the phase 1 mutually by means of the dropping liquid graduated cylinder.Described mixture stirred 30 minutes then.Make material carry out homogenizing of homogeneous by the glass on the mobile shear head (Ultra TurraxT50 (IKA-Werke), turrax bar, 8 sections (about 8500rpm)) then.

Anti-perspirant or deodorizer cloth

For the embodiment of the present invention, has 50g/m as anti-perspirant cloth or deodorizer cloth ²The single layer of substrate material of 100% viscose of aereal weight is under each situation, every square metre of emulsion 2.1 that provides 75g embodiment, 2.2 or 2.3, perhaps under each situation, provide the solution 4.1 or 4.2 of 75g embodiment, cloth is cut into suitable size and is packaged in the pouch.

Additional embodiments preparation (data are represented with wt%)

Deodorizer aerosol base 1
						1	2	3	4
Triethyl citrate	1.00	5.00	6.00	2.00
					Ethylhexyl glycerol	0.50	0.10	1.50	3.00
Phenoxyethanol	0.30	0.50	0.10	0.20
					Spice	0.50	1.50	1.00	0.50
The Ramulus et Folium Mussaendae Pubescentis extracting solution	0.05	0.10	0.15	0.20
					Aromatic	0.50	0.01	0.05	0.10
Isopropyl myristate	0.20
					The Flos Tagetis Erectae extracting solution		0.20
The Carcade extracting solution			0.30
					The myrrh extracting solution			0.10
The mixed extract of Radix Dauci Sativae and jojoba				0.20
					The Radix Malvae sylvestris extracting solution	0.05			0.20
Hydrocarbon propellant	85.00	80.00	70.00	60.00
					Modification alcohol	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorizer aerosol base 2
						1	2	3	4
Isopropyl myristate	1.00	10.00	5.00	2.00
					Phenoxyethanol	0.30	0.50	0.10	0.20
Spice	0.50	1.50	1.00	0.50
					The Ramulus et Folium Mussaendae Pubescentis extracting solution	0.05		0.05
Ethylhexyl glycerol	0.50	0.10	1.50	3.00
					The Fructus Vitis viniferae extracting solution	0.05
The Flos Tagetis Erectae extracting solution		0.10
					The Carcade extracting solution			0.15	0.50
Hydrocarbon propellant	75.00	85.00	78.00	60.00
					The alcohol of modification	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anti-perspirant aerosol base 1
						1	2	3	4
Aluminium chlorohydrate	4.00	10.00
					Activatory aluminium chlorohydrate			2.00	10.00
Distearyl Dimethyl Ammonium Strese Hofmann's hectorite. propylene carbonate (4-methyl isophthalic acid, 3-dioxolanes-2-ketone)	0.50	1.50	0.80	1.20
					Spice	0.80	0.50	1.00	1.50
Spice/activating agent of sealing (Firecaps)	1.50	0.10	1.50	0.10
					Ethylhexyl glycerol	0.50			0.25
Isopropyl myristate		1.00
					The mixed extract of Radix Dauci Sativae and jojoba	0.10
The myrrh extracting solution		0.20
					The Ramulus et Folium Mussaendae Pubescentis extracting solution			0.30
The Carcade extracting solution				0.60
					Hydrocarbon propellant	85.00	75.00	80.00	60.00
Encircle five polysiloxanes/ring six polysiloxanes	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anti-perspirant aerosol base 2
						1	2	3	4
Aluminium chlorohydrate	4.00	10.00
					Activatory aluminium chlorohydrate			2.00	10.00
Distearyl Dimethyl Ammonium Strese Hofmann's hectorite. propylene carbonate (4-methyl isophthalic acid, 3-dioxolanes-2-ketone)	0.50	1.50	0.80	1.20
					Spice	0.80	0.50	1.00	1.50
Aromatic	0.50	0.01	0.05	0.10
					Malic acid two-C12-13 Arrcostab		0.50	0.50	10.00
The palm acid ethyl hexyl ester	ad 100	5.00
					Ethylhexyl glycerol	0.50
Isopropyl myristate		0.20
					The Ramulus et Folium Mussaendae Pubescentis extracting solution			0.40
The Radix Malvae sylvestris extracting solution				0.65
					Hydrocarbon propellant	85.00	75.00	80.00	60.00
Encircle five polysiloxanes/ring six polysiloxanes		Be added to 100	Be added to 100	Be added to 100

Roll and put formula container dress deodorizer alcoholic liquor on the skin
								1	2	3	4	5	6
The alcohol of modification	35.00	30.00	28.00	30.00	30.00	40.00
							Aluminium chlorohydrate 50% solution	16.00	40.00	16.00	16.00	40.00
Pentachloro-hydrated aluminum zirconium, 40% solution						45.00
							16/polyoxyethylene octadecanol-12	2.50	1.50	2.00	2.00		2.50
16/polyoxyethylene octadecanol-30	2.50	2.00	1.50	2.00		2.50
							The PEG-40 castor oil hydrogenated					3.00
Spice	0.70	1.00	1.50	1.20	1.00	1.20
							Vitamin E acetate	0.05	0.10		0.25		0.05
Hydroxyethyl-cellulose	0.50	0.30	0.40	0.60	0.30	0.50
							Zinc gluconate		0.10			0.10	0.10
Approval is used for the pigment of cosmetics	0.0005	0.0010	0.0005	0.0100	0.0001
							The Semen Vitis viniferae extracting solution	0.20	0.50
The Carcade extracting solution			0.30	0.60
							Ethylhexyl glycerol					0.30	0.70
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Roll and put formula container dress deodorizer emulsion on the skin
								1	2	3	4	5	6
Stearyl alcohol polyethers-2	2.50	3.00	3.00	2.80	2.80	2.80
							PPG-15 octadecyl ether	2.00	3.00	2.00	2.20	2.00	2.00
Stearyl alcohol polyethers-21	1.00	1.00	3.00	1.00	1.30	1.30
							Aluminium chlorohydrate 50% solution	40.00	40.00	40.00	40.00	40.00
The coordination compound of tetrachlorohydrex aluminum and glycine, 35% solution						63.00
							Allantoin	0.10		0.10		0.10
Vitamin E acetate	0.05	0.05	0.05	0.25	0.25	0.25
							Spice	1.00	1.50	1.30	0.80	1.00	1.20
Ethylhexyl glycerol	0.10	0.50				0.20
							Isopropyl myristate			1.00
The myrrh extracting solution				0.20	0.50	0.80
							Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorizer club/soap base-alcoholic liquor
						1	2	3	4
The alcohol of modification	40.00	40.00	35.00	30.00
					1, the 2-propylene glycol	30.32	32.32	32.32	38.00
1,3 butylene glycol	12.00	10.00	15.00	12.00
					Sodium palmitate	3.10	3.50	2.80	3.10
Sodium stearate	3.10	3.50	2.80	3.10
					Glycerol 86%	2.00	1.00	1.70
The PPG-5 month silica-based polyoxyethylene ether-5	0.50	1.00	1.00	0.50
					Spice	1,00	0.60	1.30	1.00
Octadecanol	1.00	0.50	1.00	0.70
					Phenoxyethanol	1.00	0.50	1.00	0.50
Ethylhexyl glycerol	0.50		0.30
					Vitamin E acetate	0.05		0.10	0.25
PEG-40 castor oil hydrogenated isopropyl myristate	0.02	1.00		0.10
					The Carcade extracting solution	0.20		0.30
The Radix Malvae sylvestris extracting solution			0.20
					The mixed extract of Radix Dauci Sativae and jojoba				0.80
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

The pure liquid of deodorizer club/soap base-do not have
						1	2	3	4
PEG-8	40.00	45.00	50.00	46.00
					Sodium palmitate	2.50	2.50	2.50	2.50
Sodium stearate	2.50	2.50	2.50	2.50
					1,3 butylene glycol	5.00	2.00	3.00	4.00
The PEG-14 dimethicone	1.00	2.00	1.50	1.50
					Phenoxyethanol	1.00	2.00	0.50	1.00
Spice	1.00	1.20	0.80	1.00
					Ethylhexyl glycerol	0.30		0.30
Steareth-10	0.20		0.20	0.20
					The mixed extract of Radix Dauci Sativae and jojoba	0.60
The Radix Malvae sylvestris extracting solution		0.75
					The Carcade extracting solution			0.30
Isopropyl myristate				1.0
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anti-perspirant club base 1
						1	2	3	4
The PPG-14 butyl ether	15.00	18.00	12.00	19.00
					Castor oil hydrogenated	1.00	1.50	2.00	1.50
Octadecanol	20.00	18.00	15.00	18.00
					16/polyoxyethylene octadecanol-30	3.00	2.00	4.00
Isocetyl polyoxyethylene (20) ether				2.50
					Spice	1.00	1.20	0.80	1.50
Aluminium chlorohydrate	20.00	22.00	18.00
					The coordination compound of tetrachlorohydrex aluminum zirconium and glycine				22.00
Allantoin	0.10			0.10
					Cocos nucifera oil glyceride	4.00	6.00	3.00	5.00
Talcum	3.00	2.00	5.00	3.00
					Tocopherol acetas	0.20		0.50	0.10
Ethylhexyl glycerol	0.50
					Isopropyl myristate		1.00
The Carcade extracting solution			0.35
					The Radix Malvae sylvestris extracting solution				0.50
The Pentamethylene. siloxanes	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anti-perspirant club base 2
						1	2	3	4
Hexadecanol	10.00	12.00	10.00	8.00
					The PPG-14 butyl ether	6.00	5.00	6.00	8.00
Castor oil hydrogenated	4.00	5.00	6.00	5.00
					Octadecanol	12.00	14.00	11.00	16.00
Hexadecanol	6.00	5.00	6.00	3.00
					The PEG-20 tristerin	5.00	4.00	6.00	4.00
16/polyoxyethylene octadecanol-30	3.00	1.00	3.00
					Spice	1.00	1.20	0.80	1.00
Aluminium chlorohydrate	20.00	20.00	18.00
					The coordination compound of tetrachlorohydrex aluminum zirconium and glycine				23.00
Talcum	8.00	5.00	8.00	7.00
					Ethylhexyl glycerol	0.20	0.80
Tocopherol acetas	0.25		0.50
					The Ramulus et Folium Mussaendae Pubescentis extracting solution	0.30
Isopropyl myristate			1.00
					The Carcade extracting solution			0.10	1.00
Encircle five polysiloxanes	ad 100	ad 100	ad 100	ad 100

Deodorizer pumping dispersant
						1	2	3	4
The alcohol of modification	50.00	55.00	60.00	40.00
					Triethyl citrate	2.50	3.50	4.00	3.00
The PEG-40 castor oil hydrogenated	1.00	0.50	0.50	2.00
					Ethylhexyl glycerol	0.10	0.30
Vitamin E acetate	0.05	0.20	0.10
					Benzophenone-2	0.01	0.01	0.01	0.05
Approval is used for the pigment of cosmetics	0.0001	0.0005	0.0010
					Spice	0.80	1.00	2.00	1.50
The Semen Vitis viniferae extracting solution	0.20
					The myrrh extracting solution		0.15
The Carcade extracting solution		0.15
					The Flos Tagetis Erectae extracting solution			0.35
The Ramulus et Folium Mussaendae Pubescentis extracting solution				0.45
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anti-perspirant pumping dispersant (PIT technology)
						1	2	3	4
Aluminium chlorohydrate 50% solution	30.00	40.00	35.00	40.00
					Two caprylyl ethers	10.00	10.00	8.00	9.00
Glycerol 86%	5.00	3.00	5.00	3.00
					Behenyl alcohol polyethers-10	3.30	4.00	3.50	4.00
Different n-nonanoic acid 16/stearyl			4.00	5.00
					Lauric acid hexadecanol/hexyl decyl ester	3.00	5.00
Spice	1.00	0.80	1.20	1.00
					Polysorbate 20/ linoleic acid	0.20	0.20	0.50
Allantoin	0.10			0.20
					Ethylhexyl glycerol	0.50
Isopropyl myristate		0.20
					The Semen Vitis viniferae extracting solution			0.50
The mixed extract of Radix Dauci Sativae and jojoba				0.50
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorizer cloth
						1	2	3	4
The alcohol of modification	50.00	55.00	60.00	40.00
					Triethyl citrate	2.50	3.50	4.00	3.00
The PEG-40 castor oil hydrogenated	1,00	0.50	0.50	2.00
					Ethylhexyl glycerol	0.10	0.30
Vitamin E acetate	0.05	0.20	0.10
					Benzophenone-2	0.01	0.01	0.01	0.05
Approval is used for the pigment of cosmetics	0.0001	0.0005	0.0010
					Spice	0.80	1.00	2.00	1.50
The Semen Vitis viniferae extracting solution	0.25
					The Radix Malvae sylvestris extracting solution		0.30
Talcum	3.00	2.00	5.00	3.00
					The Carcade extracting solution	0.15
The Fructus Vitis viniferae extracting solution			0.50
					The Flos Tagetis Erectae extracting solution				0.40
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anti-perspirant cloth (PIT technology)
						1	2	3	4
Aluminium chlorohydrate 50% solution	30.00	40.00	35.00	40.00
					Two caprylyl ethers	10.00	10.00	8.00	9.00
Glycerol 86%	5.00	3.00	5.00	3.00
					Behenyl alcohol polyethers-10	3.30	4.00	3.50	4.00
Different n-nonanoic acid 16/stearyl			4.00	5.00
					Lauric acid hexadecanol/hexyl decyl ester	3.00	5.00
Spice	1.00	0.80	1.20	1.00
					Polysorbate 20/ linoleic acid	0.20	0.20	0.50
Allantoin	0.10			0.20
					The Fructus Vitis viniferae extracting solution	0.25	0.40
The Carcade extracting solution	0.25		0.50
					The Radix Malvae sylvestris extracting solution				0.65
Preservative system	0.50	0.20	1.00	0.50
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Limpid gelinite
						1	2	3	4
1, the 2-propylene glycol	18.00	23.00	18.00	20.00
					Aluminium chlorohydrate 50% solution	40.00	40.00	40.00	40.00
Cyclopentasiloxane	14.20	14.20	14.20	14.20
					The alcohol of modification	5.00	10.00	8.00	10.00
The BIS-PEG/PPG-14/14 dimethicone	3.50	2.50	3.20	3.00
					Spice	0.60	0.60	1.00	1.30
Allantoin		0.10
					Ethylhexyl glycerol	0.50
The Flos Tagetis Erectae extracting solution	0.20
					The Semen Vitis viniferae extracting solution		0.35
The Carcade extracting solution			0.50
					The myrrh extracting solution				0.85
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Limpid deodorizer gelinite
						1	2	3	4
The alcohol of modification	30.00	40.00	50.00	60.00
					16/polyoxyethylene octadecanol-12	1.50		2.00
16/polyoxyethylene octadecanol-20	2.50		2.00
					The PEG-40 castor oil hydrogenated		3.00		2.00
Carbomer	0.30	0.50	0.80	1.00
					Spice	0.60	0.60	1.00	1.30
The Radix Malvae sylvestris extracting solution	0.10
					The myrrh extracting solution		0.20
The Semen Vitis viniferae extracting solution	0.25			0.60
					The mixed extract of Radix Dauci Sativae and jojoba		0.15
The Carcade extracting solution			0.35
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

For obtaining limpid gel, the index of refraction of described water and the index of refraction of described oil phase mate, and water or propylene glycol are as variable.

(NaOH LiOH) regulates the pH of thickening agent (carbomer) to obtain wishing for TEA, AMP with suitable nertralizer.

The anti-perspirant cream
						1	2	3	4
Aluminium chlorohydrate 50% solution	40.00	40.00	35.00	45.00
					Tristerin	5.00	4.50	5.50	6.00
Hexadecanol	2.00	1.50	3.00	1.50
					Behenyl alcohol	1.50	4.00	3.50	5.00
Dimethicone	2.00	1.50	2.50	3.00
					16/polyoxyethylene octadecanol-12	1.50	2.00	2.50	1.30
16/polyoxyethylene octadecanol-20	1.50	2.00	2.50	1.30
					Lauric acid hexadecanol/hexyl decyl ester	3.00	4.00	2.50	2.40
Encircle five polysiloxanes	1.50	3.00	2.00	1.00
					Vitamin E acetate	0.05	0.25
Spice	0.80	1.00	1.50	2.00
					Allantoin	0.10	0.10
Preservative system	0.05	0.05	0.05	0.05
					Ethylhexyl glycerol	0.5
Isopropyl myristate		1.0
					The Carcade extracting solution		0.2	0.5	0.8
Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Anhydrous soft solid anti-perspirant cream
						1	2	3	4
Aluminium chlorohydrate	20.00	22.00	20.00
					The coordination compound of tetrachlorohydrex aluminum zirconium and glycine				24.00
Hexadecanol	5.00	4.50	5.50	6.00
					Two caprylyl ethers	3.00	4.00	3.50	5.00
Cocos nucifera oil glyceride	5.00	6.00	7.00	3.00
					Glycerol three sour C18-C36 esters	6.00	5.00	4.00	3.00
16/polyoxyethylene octadecanol-30	3.00	2.00	2.50	4.00
					The PEG-20 tristerin	5.00	6.00	3.00	2.00
Cellulose	3.00	2.00	5.00	1.00
					The Dry Flo PC	5.00	4.00	6.00	5.00
Silicon dioxide	1.00	2.00	0.50
					Talcum	10.00	5.00	7.00	12.00
Allantoin	0.10	0.10
					Spice	1.00	1.50	2.00	0.80
Ginseng extract	0.05	0.20	0.50
					The Flos Tagetis Erectae extracting solution	0.1
The myrrh extracting solution		0.3
					The Fructus Vitis viniferae extracting solution			0.5	1.0
Encircle five polysiloxanes	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorizer/anti-perspirant powder
						1	2	3	4
Aluminium chlorohydrate	20.00
					The coordination compound of tetrachlorohydrex aluminum zirconium and glycine				24.00
Silicon dioxide	2.00	2.00	1.00	1.00
					Triclosan		0.30	0.10
Sensiva SC 50			1.00
					Spice	1.00	0.50	2.00	1.00
Green tea extractive liquor	0.05		0.50
					The Ramulus et Folium Mussaendae Pubescentis extracting solution	0.1
The Fructus Vitis viniferae extracting solution		0.2	0.5
					The Carcade extracting solution			0.1	0.6
Talcum	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorant soap
						1	2	3	4
Tallow acid sodium	55.00		60.00
					Sodium palmitate		55.00		60.00
Coconut oil sodium	22.00		27.00
					Palmitoleic acid sodium		22.00		27.00
Talcum	10.00	10.00
					Plantacare APG 1200G		2.00		2.00
Spice	1.00	1.00	1.50	0.50
					Sodium chloride	0.50	0.50	0.50	0.50
Tetrasodium ethylenediamine tetraacetate	0.30	0.20	0.30	0.10
					Tocopherol	0.10	0.30
The antibacterial activity agent	0.30		0.50
					Approval is used for the pigment of cosmetics	0.01	0.05	0.03
Ethylhexyl glycerol	0.2	0.5
					Isopropyl myristate			1.0
The Carcade extracting solution				0.6
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

The deodorizer synthetic detergent
						1	2	3	4
Month silica-based polyethenoxy ether sodium sulfate	30.00	30.00	25.00	30.00
					The cocoyl sodium isethionate	15.00	12.00	20.00	15.00
Month silica-based polyoxyethylene ether sulfo-succinic acid disodium	10.00	15.00	10.00	8.00
					16 stearyl alcohol	10.00	12.00	10.00	10.00
Stearic acid	10.00	10.00	12.00	8.00
					Starch	10.00	2.00	10.00	5.00
Talcum	2.00	10.00		5.00
					Spice	0.50	1.00	0.30	0.80
Tetrasodium ethylenediamine tetraacetate	0.30	0.20	0.30	0.10
					Tocopherol acetas	0.10	0.30
Antibacterial	0.30		0.50
					Approval is used for the pigment of cosmetics	0.01	0.05	0.03
The mixed extract of Radix Dauci Sativae and jojoba	0.2	0.5
					The extracting solution of Radix Malvae sylvestris			0.5
The extracting solution of Ramulus et Folium Mussaendae Pubescentis blade				1.0
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

Deodorizer washing washing liquid
						1	2	3	4
Month silica-based polyethenoxy ether sodium sulfate		5.00	4.00
					Month silica-based polyoxyethylene ether sulfo-succinic acid disodium	6.00		2.00	8.00
Plantacare APG 1200G	4.00	5.00	4.00	4.00
					The collagen potassium of cocoyl hydrolysis	2.00	3.00	5.00	2.00
PEG-7 coconut oil glyceryl ester	3.00	3.00	5.00	3.00
					PEG-120 methyl glucoside dioleate	1.00	2.00	3.00	1.00
Spice	0.30	0.50	0.80	0.50
					Tetrasodium ethylenediamine tetraacetate	0.30	0.20		0.10
Tocopherol acetas	0.10	0.30
					Antibacterial	0.30		0.50
Citric acid	0.20	0.30	0.20	0.30
					Approval is used for the pigment of cosmetics	0.01	0.05	0.03
Ethylhexyl glycerol	0.2	0.5
					The Semen Vitis viniferae extracting solution			0.5
The Carcade extracting solution				0.8
					Water	Be added to 100	Be added to 100	Be added to 100	Be added to 100

The raw material tabulation of using

Raw material	Supplier	The INCI name
			Allantoin	Merck	Allantoin
Rezal G solution	Reheis	The coordination compound of tetrachlorohydrex aluminum and glycine, 35% solution
			Rezal 36GP SUF	Reheis	The coordination compound of tetrachlorohydrex aluminum zirconium and glycine
Locron L	Clariant	Aluminium chlorohydrate 50% solution

Microdry	Reheis	Aluminium chlorohydrate
			Microdry UF	Reheis	Aluminium chlorohydrate
Chlorhydrol solution	Reheis	Aluminium chlorohydrate 50% solution
			Reach 103	Reheis	Active aluminium chlorohydrate
Rezal 67	Reheis	Zirkonal 50,40% solution
			Dry Flo PC	National Starch	The Dry Flo PC
Cooling agent	Different	Aromatic
			Mergital B10	Cognis	Behenyl alcohol polyethers-10
Stenol 1822 A	Cognis	Behenyl alcohol
			Uvinul D 50	BASF	Benzophenone-2
Abil EM 97	Degussa	The BIS-PEG/PPG-14/14 dimethicone
			Synchrowax HGLC	Croda	Three acid glycerol C18-C36 esters
Carbopol ETD 2001	Noveon	Carbomer (with the crosslinked acrylate copolymer of allyl sucrose)
			Vitacel L-600-20 FCC Mergital CS 11	Rettenmaier	Cellulose 16/polyoxyethylene octadecanol-11
Cognis
	Eumulgin B1	Cognis		16/polyoxyethylene octadecanol-12
Eumulgin B2			Cognis		16/polyoxyethylene octadecanol-20
	Eumulgin B3	Cognis Cognis		16/polyoxyethylene octadecanol-300 six/stearyl alcohol
Lanette O
	Cetiol SN		Cognis		Different n-nonanoic acid 16/stearyl
Lorol C16		Cognis		Hexadecanol
	Novata AB		Cognis		Cocos nucifera oil glyceride
dc 245		Dow Corning Dow Corning		Encircle five polysiloxanes cyclohexyl methyl polysiloxanes/the contain poly-dimethicone of polyoxyethylene or polyoxypropylene side chain
	Dc 3225
dc 345			Dow Corning		Encircle five polysiloxanes/ring six polysiloxanes
	Cosmacol EMI	Condea		Malic acid two-C12-13 Arrcostab
Cetiol OE			Cognis		Two capryl ethers

Baysilone M350	Bayer	Dimethicone
			Powder quality	Different	Month silica-based polyoxyethylene ether sulfo-succinic acid disodium
Texapon SB 3 UP	Cognis	Month silica-based polyoxyethylene ether sulfo-succinic acid disodium
			Bentone Gel VS 5 PCV	Rheox	Distearyl Dimethyl Ammonium Strese Hofmann's hectorite. propylene carbonate (4-methyl isophthalic acid, 3-dioxolanes-2-ketone)
Fircaps	Firmenich	Spice/activating agent of sealing (Fircaps)
			Sensiva SC 50	Schülke & Mayr	Ethylhexyl glycerol
Cegesoft C24	Cognis	The palm acid ethyl hexyl ester
			Cutina MD-V	Cognis	Tristerin
Eutanol G 16	Cognis	Hexadecanol
			Cetiol PGL	Cognis	Lauric acid hexadecanol/hexyl decyl ester
Drivosol	Hüls	Hydrocarbon propellant
			Cutina HR	Cognis	Castor oil hydrogenated
Natrosol 250 HR	Hercules Aqualon	Hydroxyethyl-cellulose
			Arlasolv 200	Uniqema	Isocetyl polyoxyethylene (20) ether
Isopropyl myristate	Cognis	Isopropyl myristate
			Plantacare 1200 UP	Cognis	Plantacare APG 1200G
Eutanol G	Cognis	Octadecanol
			Perfume	Different	Spice
Glucamte DOE 120	Amerchol	PEG-120 methyl glucoside dioleate
			Abil B 8843	Degussa	The PEG-14 dimethicone
Cutina E 24	Cognis	The PEG-20 tristerin
			Eumulgin HRE 40	Cognis	The PEG-40 castor oil hydrogenated
Cetiol HE	Cognis	PEG-7 coconut oil glyceryl ester
			Phenoxyethanol	Bayer	Phenoxyethanol
Plant extract	Different	Plant extract
			Vitamin F water soluble	Crodarom	Polysorbate 20/ linoleic acid
Lamepon S	Cognis	The collagen potassium of cocoyl hydrolysis

Ucon Fluid AP	Ucon	The PPG-14 butyl ether
			Arlamol E	Uniqema	PPG-15 octadecyl ether
Aethoxal B	Cognis	The PPG-5 month silica-based polyoxyethylene ether-5
			Aerosil 200	Degussa	Silicon dioxide
Aerosil 200	Degussa Degussa	Silicon dioxide silicon dioxide dimetylsilyl thing
			Aerosol R 972
Soap based on Edenor K12-18				Cognis	Coconut oil sodium
	Powder quality	Different	Month silica-based polyethenoxy ether sodium sulfate
Texapon NSO UP				Cognis	Month silica-based polyethenoxy ether sodium sulfate
	Soap based on Edenor	Cognis	Palmitoleic acid sodium
Soap based on Cutina FS 45				Cognis	Sodium palmitate
	Soap based on Edenor C16-98/100	Cognis	Sodium palmitate
Soap based on Cutina FS 45				Cognis	Sodium stearate
	Soap based on Edenor TIS GAH	Cognis	Tallow acid sodium
Powder quality				Different	The cocoyl sodium isethionate
	Brij 76	Uniqema	Stearyl alcohol polyethers-10
Brij 72				Uniqema	Stearyl alcohol polyethers-12
	Brij 721	Uniqema	Stearyl alcohol polyethers-21
Lorol C18				Cognis	Octadecanol
	Lorol C18	Cognis	Octadecanol
Steasilk 5 GGHT				Luzenac	Talcum
	Talcum Pharma G	Grolmann	Talcum
Trilon B liq.				BASF	Tetrasodium ethylenediamine tetraacetate
	Vitamin E	Roche	Tocopherol

Vitamin E acetate	BASF	Vitamin E acetate
			Irgasan DP 300	Ciba Spec.	Triclosan
Citrofol AL	Jungbunzlauer	Triethyl citrate
			Zinc gluconate	Interorgana	Zinc gluconate

Leaf extract from white tea		Cosmetochem
			Carcade extract		Cosmetochem
Flower extract from mallow		Cosmetochem
			Grape extract		Cosmetochem
Mixed extract from carrot and jojoba		Cosmetochem
			Myrrh extract		Cosmetochem
Marigold extract		Cosmetochem
			Grape seed extract		Cosmetochem
Green tea extract		Dragoco

Claims (48)

1. the material that skin is had a prebiotic effect is in the local beauty of the skin growth of microorganism that is used for promoting the wishing purposes with skin care compositions and methods.

2. purposes as claimed in claim 1, the skin microorganism that is characterised in that described hope are saprophytic skin microorganisms.

3. as the purposes of claim 1 or 2, the skin microorganism that is characterised in that described hope is the neutral skin microorganism of abnormal smells from the patient.

4. purposes as claimed in claim 3 is characterised in that the neutral skin microorganism of described abnormal smells from the patient is the neutral staphylococcus of abnormal smells from the patient.

5. purposes as claimed in claim 4 is characterised in that the neutral staphylococcus of described abnormal smells from the patient is a staphylococcus epidermidis.

6. as the purposes of one of claim 1-5, be characterised in that the material that skin is had prebiotic effect, simultaneously undesirable skin growth of microorganism had depression effect.

7. the material that skin is had a prebiotic effect is being used for suppressing the purposes of the local beauty of undesirable skin growth of microorganism with skin care compositions and methods.

8. purposes as claimed in claim 7 is characterised in that described undesirable microorganism is the microorganism that forms stink.

9. purposes as claimed in claim 8, the microorganism that is characterised in that described formation stink are the staphylococcuses that forms stink, the positive anaerobic cocci of gram (dyeing), the micrococcus of the coryneform bacteria of formation stink or formation stink.

10. purposes as claimed in claim 9, the staphylococcus that is characterised in that described formation stink is a staphylococcus hominis.

11. purposes as claimed in claim 9 is characterised in that the positive anaerobic cocci of described gram (dyeing) is that anaerobic cocci belongs to octavius (Anaerococcus octavius).

12. as the purposes of one of claim 1-11, be used to handle spot, skin dryness or butyrous.

13., be used to handle body odor as the purposes of one of claim 1-11.

14., be used to handle the dermatophytes or the dandruff as the purposes of one of claim 1-11.

15. the purposes of one of claim is characterised in that described skin is the skin of arm-pit areas as described above.

Be used for the local beauty usefulness of skin benefit life nursing or the purposes of Pharmaceutical composition 16. skin is had the material of prebiotic effect in production.

17., be characterised in that described benefit comes into force to realize by promoting to wish growth of microorganism as the purposes of claim 16.

18. as the purposes of claim 17, the microorganism that is characterised in that described hope is the neutral staphylococcus of abnormal smells from the patient.

19., be characterised in that described benefit comes into force to realize by suppressing undesirable growth of microorganism as the purposes of one of claim 16-18.

20. as the purposes of claim 19, be characterised in that described undesirable microorganism is the staphylococcus that forms stink, the positive anaerobic cocci of gram (dyeing), the micrococcus of the coryneform bacteria of formation stink or formation stink.

21., be characterised in that described material with prebiotic effect is a plant extract as the purposes of one of claim 1-20.

22. as the purposes of claim 21, be characterised in that described plant extract is a tea juice, the particularly plant extract from Theaceae or Radix Malvae sylvestris, or Vitaceae, Radix Asteris section, the extracting solution of umbrella flower section or Buxaceae or its mixture.

23. purposes as claim 22, be characterised in that described plant extract is Flos Camelliae Japonicae kind (Camellia spec.), Hibiscus kind (Hibiscus spec.), Radix Malvae sylvestris kind (Malva spec.), Fructus Vitis viniferae kind (Vitis spec.), wild celery kind (Daucus spec.), bdellium kind (Commiphoraspec.), Jojoba genera kind (Simmondsia spec.), perhaps Calendula arvensis L. kind (Calendulaspec.), the perhaps extract of its mixture.

24. purposes as claim 23, be characterised in that described plant extract is tea (Camellia sinensis), Calyx Hibisci Sabdariffae (Hibiscus sabdariffa), Radix Malvae sylvestris (Malvasylvestris), Fructus Vitis viniferae (Vitis viticola), Daucus carota L. (Daucus carota), myrrh (Commiphora myrrha), jojoba (Simmondsia chinensis) or Flos Inulae (Calendula officinalis), the perhaps extract of its mixture.

25., be characterised in that described material with prebiotic effect is a glycerol monoalkyl ether as the purposes of one of claim 1-20.

26., be characterised in that described glycerol monoalkyl ether is 1-(2-ethylhexyl) glycerin ether as the purposes of claim 25.

27., be characterised in that described material with prebiotic effect is an organic acid esters as the purposes of one of claim 1-20.

28., be characterised in that described ester is isopropyl myristate or myristic acid ethyl ester as the purposes of claim 27.

29., be characterised in that described skin nursing is preventative as the purposes of one of claim 1-28.

30., be characterised in that described content with material of prebiotic effect is 0.01-20wt% based on composition total weight as the purposes of one of claim 1-29.

31. a beauty treatment is used or Pharmaceutical composition, comprises the material that skin is had prebiotic effect.

32. the beauty treatment as claim 31 is used or Pharmaceutical composition, is characterised in that described skin is the skin of arm-pit areas.

33. as the beauty treatment of claim 31 or 32 with or Pharmaceutical composition, be characterised in that the described material that skin is had a prebiotic effect is a plant extract.

34. the beauty treatment as claim 33 is used or Pharmaceutical composition, be characterised in that described plant extract is a tea juice, particularly from Theaceae, the plant extract in Vitaceae or the Radix Malvae sylvestris, or Radix Asteris section, the extracting solution in umbrella flower section or Buxaceae or its mixture.

35. the beauty treatment as claim 34 is used or Pharmaceutical composition, be characterised in that described plant extract is Flos Camelliae Japonicae kind (Camellia spec.), Hibiscus kind (Hibiscus spec.), Radix Malvae sylvestris kind (Malva spec.), Fructus Vitis viniferae kind (Vitis spec.), wild celery kind (Daucus spec.), bdellium kind (Commiphora spec.), Jojoba genera kind (Simmondsia spec.), perhaps Calendula arvensis L. kind (Calendula spec.), the perhaps extracting solution of its mixture.

36. the beauty treatment as claim 35 is used or Pharmaceutical composition, be characterised in that described plant extract is tea (Camellia sinensis), Calyx Hibisci Sabdariffae (Hibiscus sabdariffa), Radix Malvae sylvestris (Malva sylvestris), Fructus Vitis viniferae (Vitis viticola), Daucus carota L. (Daucus carota), myrrh (Commiphora myrrha), jojoba (Simmondsia chinensis) or Flos Inulae (Calendula officinalis), the perhaps extract of its mixture.

37. the beauty treatment as claim 31 or 32 is used or Pharmaceutical composition, is characterised in that described material with prebiotic effect is a glycerol monoalkyl ether.

38. the beauty treatment as claim 37 is used or Pharmaceutical composition, is characterised in that described glycerol monoalkyl ether is 1-(2-ethylhexyl) glycerin ether.

39. the beauty treatment as claim 31 or 32 is used or Pharmaceutical composition, is characterised in that described material with prebiotic effect is an organic acid esters.

40. the beauty treatment as claim 39 is used or Pharmaceutical composition, is characterised in that described ester is isopropyl myristate or myristic acid ethyl ester.

41. the beauty treatment as one of claim 31-40 is used or Pharmaceutical composition, is characterised in that it comprises at least a following at least one group of other material that be selected from:

-organically, inorganic and inorganic photoprotection filter modification,

-be selected from the vitamin of vitamin B complex, rovitamin or previtamin thing, or derivatives thereof and 2-furanone, pantothenylol, pantolactone, the derivant of nicotiamide and biotin,

-other plant extract,

-MMP-1-inhibitor,

-retinol (vitamin A ₁) and C _2-18The ester of carboxylic acid,

-enzyme inhibitor, stabilizing agent, deodorizer active component, oil, wax.

42. the beauty treatment as one of claim 31-41 is used or Pharmaceutical composition, is characterised in that it comprises at least a following at least one group other material that is selected from:

-surfactant, as emulsifying agent or dispersant,

The salt of-aminoacid and its zinc salt and its sour addition,

-film forming and/or stable emulsion, and/or thickening and/or adhesive polymer,

-lipid, surfactant, anti-perspirant and polyol,

-organically, inorganic and inorganic photoprotection filter modification,

-protein hydrolysate and its derivant,

-single, oligomeric and polysaccharide and its derivant,

-alpha-hydroxy carboxylic acid compounds and α-keto-carboxylic acid, and ester, lactone, perhaps its salt form.

43. the beauty treatment as one of claim 31-42 is used or Pharmaceutical composition, is characterised in that it is the local skin care composition.

44. the beauty treatment as one of claim 31-43 is used or Pharmaceutical composition, is characterised in that it is present in soap, washing liquid, and powder, synthetic detergent, foam, club, emulsion, spray, cream, gelinite is in shampoo or the ointment.

45. the beauty treatment as one of claim 31-44 is used or Pharmaceutical composition, is characterised in that described compositions is deodorizer and/or anti-perspirant.

46. a method of determining to have in arm-pit areas the prebiotic effect material may further comprise the steps:

A) from have strong and weak abnormal smells from the patient experimenter, obtain comparative sample,

B) composition of the methods analyst comparative sample by biomolecular science is determined to compare in having strong abnormal smells from the patient experimenter to a greater extent or the microorganism that occurs on the littler degree with having weak abnormal smells from the patient experimenter,

C) search material goods storehouse suppresses the material that the growth of microorganism of degree increase appears in basis (b) to seek, and/or promotes to occur according to (b) material of the lower growth of microorganism of degree.

47. method that is used to determine to have the prebiotic effect material in arm-pit areas, be characterised in that search promotes neutral aureus growth of abnormal smells from the patient and/or physiologically active, and/or suppress to form the staphylococcus of stink and/or the material of positive anaerobic cocci growth of gram (dyeing) and/or physiologically active simultaneously.

48. a material obtains by the method as claim 46 or 47.