CN115192501A - Cosmetic composition for skin protection comprising extracts of rice, reed, corn silk, malva sylvestris and aloe vera - Google Patents
Cosmetic composition for skin protection comprising extracts of rice, reed, corn silk, malva sylvestris and aloe vera Download PDFInfo
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- CN115192501A CN115192501A CN202210355636.2A CN202210355636A CN115192501A CN 115192501 A CN115192501 A CN 115192501A CN 202210355636 A CN202210355636 A CN 202210355636A CN 115192501 A CN115192501 A CN 115192501A
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- Prior art keywords
- skin
- reed
- cosmetic composition
- rice
- aloe
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- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a skin-protecting cosmetic composition comprising, as an active ingredient, a mixed extract obtained by mixing rice, reed, corn silk, mallow, and aloe, and more particularly, to a skin-protecting cosmetic composition comprising, as an active ingredient, a mixed extract obtained by mixing 0.1% to 40.0% of each of rice, reed, corn silk, mallow, and aloe. The cosmetic composition of the present invention provides a sustained moisturizing effect, has skin calming, antioxidant, whitening and anti-inflammatory effects, and has the advantages of no skin irritation and no side effects.
Description
Technical Field
The present invention relates to a cosmetic composition for skin protection comprising a mixed extract of oryza sativa, reed, corn silk, mallow and aloe vera as an active ingredient, and more particularly, to a composition for skin protection exhibiting skin moisturizing, skin calming, antioxidant, whitening and anti-inflammatory activity effects.
Background
Generally, the skin is composed of epidermis, dermis, and subcutaneous adipose tissue, and can protect the skin in external environments such as physical and chemical stimuli. However, direct exposure to external environments such as excessive ultraviolet light or pollutants induces skin irritation and inflammatory reactions such as erythema, edema, and itching. Such skin allergy is not only a problem in terms of beauty, but also skin damage such as promotion of collapse of collagen (collagen), elastin (elastin), hyaluronic acid (hydraronic acid), mucopolysaccharide (Mucopolysaccharide), and the like, which are involved in skin elasticity, is caused by pigmentation of substances generated during inflammatory reaction.
The epidermis forms the structure of stratum corneum, granular layer, thorn cortex, stratum basale from outside to inside in proper order, and the stratum corneum is located skin outermost and is protected inside the skin, is protecting skin just like wall brick.
In particular, intercellular lipids between keratinocytes have been reported to act like stucco and thus constitute a skin barrier (J.invest. Dermatol.80 (suppl.), 44-49.1983).
By this action, the stratum corneum of the epidermis in normal skin contains about 10% to 20% of water, and cells and intrinsic proteins constituting the skin can function normally.
In particular, the surface of the stratum corneum is covered with a thin natural protective film formed by sebum secreted from sebaceous glands and sweat secreted from sweat glands, and evaporation of water can be prevented.
On the contrary, if the water retention ability of the epidermal layer is lost, the water content of the horny layer is reduced to less than 10%, the elasticity and flexibility of the skin are lost, and the skin becomes dry and rough. This induces the drying of the skin, which becomes a cause of inflammation and allergy, and reduces the activity of keratinocytes and fibroblasts. Not only does not maintain normal skin moisturization, but also loses skin elasticity and health.
Further, the reduction in skin elasticity is caused by the reduction in water retention, and the elasticity of collagen and elastin supporting the pore wall of the skin is reduced, so that the pore-tightening force is weakened and the pores are dilated. As the pores expand and dry to disable the skin barrier, inflammation occurs as bacteria invade, and thus, it is very important to maintain the moisture content of the stratum corneum of the skin.
The phenomenon of decreased elasticity accompanying skin aging is caused by decrease in skin elasticity due to decrease in fibroblast division, decrease in collagen synthesis and increase in MMP production caused by photoaging caused by ultraviolet rays, increase in age, and phenomena caused by internal factors such as menopause, genetic factors and environmental factors. In particular, around age 40, the hormone balance is disrupted, and the ability to produce skin lipids, which play an important role in cell regeneration, collagen synthesis, and skin moisturization, is greatly reduced. With the increasing demand for youthful exterior and the increasing desire for cosmetics by consumers, research on cosmetics aiming at improving the above-mentioned decrease in skin elasticity is also actively being conducted.
Currently, in order to prevent the disappearance of water in the skin, occlusive agents (occlusive agents) which are hydrophobic substances such as vaseline, lanolin, cacao butter, mineral Oil, jojoba Oil, shea butter, and silica gel are used, and in order to prepare cosmetics, 20 to 50 kinds of common raw materials such as Sodium Lauryl Sulfate (Sodium Lauryl Sulfate), dimethyl Sulfoxide (Dimethyl Sulfoxide), croton Oil (Croton Oil), and Sodium hydroxide are conventionally used. When the raw materials are added into the product, the skin is stimulated, immune reactions such as pruritus, allergy, skin inflammation and the like are also accompanied, and the percutaneous Water Loss (transepidem Water Loss) of the horny layer is increased, so that the skin inflammation is induced.
Therefore, conventional moisturizing agents contained in cosmetic compositions have limitations in terms of skin moisturizing effects, protective effects, and the like, because they have side effects of causing irritation and allergy associated with inflammation.
In order to compensate for the above problems, a component having a structure similar to sebum or a polyol such as Natural Moisturizing Factor (NMF) and a triol having 3 hydroxyl groups (-OH) is added to a cosmetic to function as a moisturizer.
However, the polyol has disadvantages of being too viscous or sticky to the touch due to its inherent viscosity and physical properties, and also has a sticky or uncomfortable feeling in use due to the influence of temperature and humidity according to geographical or environmental changes, and conversely, there sometimes occurs a problem that moisture is taken away by the polyol.
In order to solve the above problems, research and development of cosmetics in which physiologically active materials derived from natural sources, such as animals, plants, and microorganisms, are introduced into cosmetics to maintain or even improve the inherent defense ability of the skin, thereby suppressing the loss of moisture in the skin and increasing the elasticity and moisturizing ability have been actively conducted recently.
Therefore, the present research has been made in an effort to develop a physiologically active material having skin moisturizing, skin calming, antioxidant and anti-inflammatory effects and a stable cosmetic for moisture retention from existing plant extracts.
Documents of the prior art
Patent document
Patent document 0001: korean laid-open patent publication No. 10-2016-0036120 (2016, 04/04) for the preparation of cosmetic compositions comprising extracts of rice, chia seed, mung bean, oat, quinoa, coix seed, and silk protein as the active ingredients.
Patent document 0002: korean patent laid-open publication No. 10-2193209 (issued 12/18/2020), "a skin whitening cosmetic composition comprising reed extract as an active ingredient".
Patent document 0003: korean laid-open patent publication No. 10-2016-0045289 (2016, 27/04) discloses a cosmetic composition for skin whitening comprising a corn silk fermentation broth.
Patent document 0004: korean laid-open patent publication No. 10-2011-0016536 (published 18.02/2011), "skin whitening cosmetic composition comprising mallow extract or mallow extract and american pinus bark extract".
Patent document 0005: korean granted patent publication No. 10-0614467 (published 2006, 08/25/month), "A whitening cosmetic composition comprising a mixed extract of Euphorbiae Helioscopiae, moutan cortex Radicis and Aloe vera for inhibiting melanin production".
Disclosure of Invention
Technical problem to be solved
In order to solve the above problems, an object of the present invention is to provide the following cosmetic composition: contains mixed extracts of Oryza sativa, phragmites communis, stigma Maydis, malva sylvestris and Aloe vera as effective components, and has skin moisturizing, skin tranquilizing, antioxidant, skin whitening and antiinflammatory effects.
Technical scheme for solving problems
In order to achieve the above objects, the present invention provides a cosmetic composition having skin moisturizing, tranquilizing, antioxidant and whitening effects, comprising mixed rice, reed, corn silk, malva sylvestris and aloe vera and extracting the mixed extract as an effective ingredient.
And the weight ratio of the rice extract, the reed extract, the malva sylvestris extract and the aloe extract is 0.1-40.0: 0.1-40.0.
The extract is extracted with one or more extraction solvents selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, ethyl acetate, glycerin and ethylene glycol.
The cosmetic composition is formulated into lotion, skin care emulsion, milky lotion, cream, foundation, essence, gel, pack, emulsion type sunscreen cream, emulsion type foundation, emulsion type pre-emulsion, oil cake type foundation, dry and wet dual-purpose cake or cake.
Advantageous effects of the invention
The cosmetic composition for skin protection of the present invention comprising the mixed extract of rice, reed, corn silk, malva sylvestris and aloe vera having skin moisturizing, calming, antioxidant, whitening and anti-inflammatory activities provides skin moisturizing, calming, antioxidant, whitening and anti-inflammatory effects.
Drawings
Fig. 1 is a bar graph showing cytotoxicity of example 1 to example 7.
Fig. 2 is a bar graph showing skin moisturizing and improving effects of comparative example 1, comparative example 2, and preparation examples 1 to 7.
Fig. 3 is a bar graph showing evaluation of the amount of moisture loss through the skin in comparative example 1, comparative example 2, and preparation examples 1 to 7.
Fig. 4 is a bar graph showing skin-calming effects of comparative example 1, comparative example 2, and preparation examples 1 to 7.
Fig. 5 is a bar graph showing the radical scavenging effect of examples 1 to 7.
Fig. 6 and 7 are bar graphs illustrating skin whitening effects of examples 1 to 7.
Fig. 8 is a bar graph showing the anti-inflammatory effects of examples 1 to 7.
Detailed Description
The following detailed description of the present invention refers to the accompanying drawings that illustrate embodiments of the invention, by way of example only, in which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention. It is to be understood that the various embodiments of the invention, although different, are not necessarily mutually exclusive. For example, certain phenomena, structures and characteristics described herein in connection with one embodiment may be implemented as other embodiments without departing from the spirit and scope of the invention. It is to be understood that the position and arrangement of individual components in the described embodiments may be changed without departing from the spirit and scope of the present invention.
The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims and all equivalents thereof, if any. In the drawings, like numerals refer to the same or similar functionality in many respects.
Terms used in the present invention are different according to intentions or examples of a person having ordinary skill in the art to which the present invention pertains, the appearance of new technology, and the like, although common terms used widely at present are selected as much as possible in consideration of functions in the present invention. In addition, in a specific case, there is a term that the applicant arbitrarily selected, and in this case, the meaning thereof will be described in detail in the relevant specification section. Therefore, the terms used in the present invention should be defined based on their own meanings and the entire contents of the present invention, and should not be understood only by the names of the terms.
In the present invention, when a part "includes" a certain structural element, unless otherwise specified, it does not mean that other structural elements are excluded, but means that other structural elements may be included.
The present invention provides a cosmetic composition comprising rice, reed, corn silk, malva sylvestris and aloe as effective ingredients and having skin moisturizing, tranquilizing, antioxidant, whitening and anti-inflammatory effects.
The above-mentioned "Rice (Oryza Sativa (Rice)" is an annual herbaceous plant belonging to the family Gramineae (Gramineae), and is widely distributed throughout the entire asia (zheng le gay, etc., korea society for applied life chemistry, 2014, 26.
The above-mentioned "reed (Phragmitis Communis)" is a monocotyledonous plant belonging to the family Gramineae of the order Gramineae, and mainly grows near the sea or in rivers and wetlands. The roots and stems of reed are known to contain carbohydrates, proteins, fats and asparagine, and it has been reported that the efficacy of reed has antioxidant activity and skin whitening effect (Bingdong column, etc., korean food Nutrition society 2015, 28 (4): 666-675).
The "Corn Silk (Zea Mays (Corn) Silk)" refers to an ear of Corn, which is a byproduct of Corn, and is also called Corn Silk or sorghum Silk. Corn stigma contains a considerable amount of vitamin K, and flavonoids such as maysin, apinaysinm, methoxynaysin, etc., particularly contain a large amount of maysin. These ingredients are known to have the proliferation inhibitory activity of corn earworm (corn earworm), cytotoxic effect on tumor cell lines, radical-scavenging activity, etc. (Jinxiying et al, korea society for crop production, 2016, 61 (3): 184-190).
The above-mentioned "Malva Sylvestris (Mallow)" is an annual plant having purple flowers and low leaves, and is grown in humid places such as seaside, wetland, river, etc. Malva sylvestris comprises malvidine a (malvone a), naphthoquinone (naphthoquinone), monoterpenes (monoterpenes), tetrahydroxylated acyclic diterpenes (tetrahydroxylated acyclic diterpenes), anthocyanidins (anthocyanins), and the like, and has plasma cholesterol lowering, neutral fat lowering, wound healing, inflammation treating, and antibacterial effects (Seyed Mehdi Razavi et al, iran J Basic Med sci,2011,14 (6): 574-579).
The above-mentioned "Aloe (Aloe Barbadensis)" belongs to the genus Aloe (Aloineae) of the family Liliaceae (Liliaceae) inhabiting tropical places. Aloe contains compounds such as fatty acids, organic acids, and flavonoids, contains anthraquinone, anthrone, chromone, pyrone, amino acids, vitamins, and minerals, and has been known to have antibacterial, antioxidant, antiallergic, collagen decomposition and regeneration promoting, and ultraviolet protective effects (Zhao Enhui et al, korea Biotechnology, 2014, 29 (6): 437-442).
In order to impart moisturizing, skin-tranquilizing, antioxidant, whitening and anti-inflammatory effects to the skin, the present invention uses, as active ingredients, extracts of rice, reed, corn silk, mallow and aloe, which contain natural moisturizing factors, natural polysaccharide ingredients such as amino acids and mucins.
The rice extract, the reed extract, the corn silk extract, the mallow extract and the aloe extract have a certain degree of activity effects in terms of skin moisturizing, skin calming, antioxidation, whitening and anti-inflammation, and in the present invention, it has been found that a mixture of two or more of the above-mentioned raw materials, preferably a composition in which rice, reed, corn silk, mallow and aloe are mixed and extracted has an excellent synergistic effect compared to a composition in which each raw material is extracted alone.
According to a preferred embodiment of the present invention, the proportions of the mixture prepared by mixing equal amounts of the rice, reed, corn silk, malva sylvestris and aloe of the present invention may include the following proportions.
Preferably, the mixture is prepared by mixing rice, reed, corn stigma, malva sylvestris and aloe in a weight ratio of 0.1-40.0: 0.1-40.0.
On the other hand, the mixture is more preferably a mixture of pulverized raw materials obtained by pulverizing rice, reed, corn silk, malva sylvestris and aloe.
Preferably, the mixed extract of the present invention is an extract obtained by extracting a mixture of mixed rice, reed, corn silk, mallow and aloe using one or more extraction solvents selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, ethyl acetate, glycerin and ethylene glycol.
The mixed extract of the present invention is more suitably prepared as follows: reflux-extracting the mixture of mixed rice, reed, corn stigma, malva sylvestris and aloe at 60-90 deg.C for 3 times, each for 2-6 hr, cold-soaking at room temperature, filtering with filter paper, concentrating under reduced pressure at 30-70 deg.C, and freeze-drying.
In the cosmetic composition having skin moisturizing, tranquilizing, antioxidant, whitening and anti-inflammatory effects according to the present invention, which comprises the mixed extract of rice, reed, corn silk, mallow and aloe as an active ingredient, at least the mixed extract is contained in an amount of 0.001 to 30.0 wt%, more preferably 0.01 to 20.0 wt%, and still more preferably 0.1 to 10.0 wt% in a final form.
If the content of the above-mentioned mixed extract is less than 0.001 wt%, the skin moisturizing effect is not exhibited, and if the content is 30 wt% or more, the effect is not greatly increased, which causes problems in safety and stability of the dosage form, and the economical efficiency is also reduced accordingly.
The cosmetic composition for skin moisturization of the present invention is a composition based on basic data of skin science, and can achieve substantially long-term effects in skin moisturization when a mixed extract obtained by separately mixing rice, reed, corn silk, mallow, and aloe is used as an active ingredient.
The cosmetic composition of the present invention contains, in addition to the above-mentioned mixture of the present invention prepared by extracting rice, reed, corn silk, malva and aloe, respectively, and mixing them, ingredients generally used in cosmetic compositions, for example, usual adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and perfumes, and a carrier.
The cosmetic composition of the present invention may be prepared in any form that is generally prepared in the art to which the present invention pertains, and for example, may be formulated as a solution, a suspension, an emulsion, a makeup cream, a gel, a cream, an emulsion, a powder, a soap, a surfactant-containing lotion, an oil agent, a powder foundation, an emulsion foundation, a wax foundation, a spray, and the like, but is not limited thereto. More specifically, the skin softening cosmetic water can be prepared into dosage forms such as softening cosmetic water, nourishing cream, massage cream, essence, facial mask, eye cream, cleansing foam, makeup remover, facial mask, spray or powder.
When the formulation of the present invention is a makeup base, a cream or a gel, one or more selected from animal oil, vegetable oil, wax, paraffin, starch, tragacanth, a cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc and zinc oxide may be used as a carrier component.
In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silicon dioxide, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and particularly in the case of a spray, an accelerator such as chlorofluorocarbon, propane/butane or dimethyl ether may be further contained.
When the formulation of the present invention is a solution or a suspension, a solvent, a dissolving agent or an opacifying agent is used as a carrier component, and for example, one or more of water, ethanol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, butylene glycol, 1, 3-butylene glycol oil, polyoxyethylene hydrogenated castor oil, glycerol, glycerin, fatty esters, phenoxyethanol, triethanolamine, polyethylene glycol, beeswax, polysorbate 60, sorbitan sesquioleate, paraffin, sorbitan stearate, oleophilic mono fatty acid glyceride, stearic acid, glyceryl stearate/PEG-400 stearate, carboxyl polymers, sitosterol, polyglycerol 2-oleate, ceramide, cholesterol, steareth-4 (steareth-4), dicetyl phosphate, macadamia nut oil, carboxyvinyl polymers, xanthan gum, or fatty acid esters of sorbitol may be selected and used.
In the case where the dosage form of the present invention is a suspension, one or more of water, liquid diluents such as ethanol, glycerin, butylene glycol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitol ester, microcrystalline cellulose, hydroxyethyl cellulose, sodium hyaluronate, phenoxyethanol, aluminum metahydroxide, bentonite, stearic acid, cetyl alcohol, glyceryl monostearate, polyoxyethylene sorbitan monostearate, sorbitol sesquioleate, glyceryl monostearate/stearate/polyoxyethylene stearate, waxes, paraffins, squalane, caprylic/capric triglyceride, carboxyvinyl polymers, triethanolamine, agar or tragacanth may be selected for use as the carrier component.
In the case where the formulation of the present invention is a surfactant-containing lotion, one or more of fatty alcohol sulfate, fatty alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazoline derivative, methyl taurate, sarcosinate, fatty acid amide ether sulfate, alkylamino betaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerin fatty acid ester may be selected as the carrier component.
In addition, the efficacy of the cosmetic composition according to an embodiment of the present invention can be appropriately adjusted according to the skin condition, health condition and external environmental conditions of an individual.
The present invention will be described in detail below with reference to examples and experimental examples to assist understanding of the present invention. However, the following examples and experimental examples are provided only for the purpose of understanding the present invention, and should not be construed as limiting the technical level and scope of the present invention. The examples and experimental examples of the present invention are provided to more fully explain the present invention to those skilled in the art.
Example 1 preparation of Rice extract
After washing and drying the rice in running pure water, all the rice was pulverized and filtered by a 100-mesh screen to ensure only finely pulverized rice. The rice extract was prepared by adding the pulverized rice to 50% ethanol to a concentration of 50g/L, reflux-extracting for 3 times each for 4 hours, cold-soaking at room temperature, filtering with whatman # 3 filter paper, concentrating under reduced pressure at a temperature of 50 ℃ or lower, and freeze-drying.
Example 2 preparation of Phragmites communis extract
After washing and drying reed in running pure water, the whole was pulverized and filtered with a 100-mesh screen to ensure only finely pulverized material. The extract of reed was prepared by adding crushed reed to 50% ethanol to a concentration of 50g/L, extracting under reflux for 3 times each for 4 hours at room temperature, filtering with whatman # 3 filter paper, concentrating under reduced pressure at a temperature of 50 ℃ or lower, and freeze-drying.
Example 3 preparation of corn stigma extract
The corn silk was washed with running pure water, dried, and then all pulverized, and then filtered using a 100-mesh filter screen to ensure only finely pulverized material. The stigma Maydis extract is prepared by adding pulverized stigma Maydis 50% ethanol to give a concentration of 50g/L, reflux-extracting for 3 times each for 4 hr, cold-soaking at room temperature, filtering with whatman # 3 filter paper, concentrating under reduced pressure at 50 deg.C or lower, and freeze-drying.
Example 4 preparation of Malva sylvestris extract
After washing and drying malva sylvestris in running pure water, all the malva sylvestris was pulverized and filtered through a 100-mesh filter screen to ensure only finely pulverized products. Adding crushed Malva sylvestris into 50% ethanol to reach a concentration of 50g/L, reflux-extracting for 3 times each for 4 hr, cold-soaking at room temperature, filtering with whatman # 3 filter paper, concentrating under reduced pressure at a temperature below 50 deg.C, and freeze-drying to obtain Malva sylvestris extract.
Example 5 preparation of Aloe extract
After washing aloe in running pure water and drying, all the aloe powder was ground and filtered through a 100-mesh filter screen to ensure only finely ground aloe powder. Adding aloe pulverized material into 1kg 50% ethanol aqueous solution to make concentration of 50g/L, reflux-extracting at 60-90 deg.C for 3 times, 4 hr each time, cold soaking at room temperature, filtering with whatman # 3 filter paper, concentrating under reduced pressure at below 50 deg.C, and freeze drying to obtain aloe extract.
Example 6 Mixed extract A
In the same manner as in examples 1 to 5, 50g of a mixture of pulverized raw materials obtained by pulverizing rice, reed, corn silk, malva sylvestris and aloe, respectively, in a weight ratio of 1: 1, was added with 1kg of 50% ethanol aqueous solution, and then extracted under reflux at 60 to 90 ℃ for 3 times, 4 hours each, by cold soaking at room temperature, filtered using whatman # 3 filter paper, and then concentrated under reduced pressure at a temperature of 50 ℃ or lower and freeze-dried to prepare a mixed extract.
Example 7 Mixed extract B
In the same manner as in examples 1 to 5, 50g of a mixture of pulverized raw materials obtained by pulverizing rice, reed, corn silk, malva sylvestris and aloe, respectively, in a weight ratio of 3.2: 2.5: 5.0: 3.0 was added with 1kg of 50% ethanol aqueous solution, and then, the mixture was refluxed and extracted at 60 to 90 ℃ for 3 times, 4 hours each time, cold-dipped at room temperature, filtered using whatman # 3 filter paper, concentrated under reduced pressure at a temperature of 50 ℃ or lower, and freeze-dried to prepare a mixed extract.
Preparation examples 1 to 7 and comparative examples 1 to 2 cosmetic compositions were prepared
The rice extract, reed extract, corn silk extract, malva sylvestris extract, and aloe extract of examples 1 to 5 described above and the mixed extracts a and B of mixed rice, reed, corn silk, malva sylvestris, and aloe of examples 6 to 7 were prepared as preparation examples 1 to 7, as shown in table 1 below.
Also, for the purpose of comparing preparation examples 1 to 7, cosmetic compositions comparative examples 1 to 2 not including any one of example 1 to example 7 were prepared.
TABLE 1
Experimental example 1 cell viability assay: MTT assay
1) Experimental method
The influence of the samples prepared in examples 1 to 7 on cell growth was confirmed. In order to confirm cell proliferation and toxicity, experiments were performed as follows.
Cells 3T3 (fibroblast cell line) in culture were seeded in 96-well microplate at a cell/well ratio of 5000 cells/well, and then cultured in a thermostatic bath for 30 minutes, and then samples were added at different concentrations of 0.0008, 0.0016, 0.0048, 0.008, 0.0112, and 0.0114 (%, W/V), and then cultured for 72 hours.
After 72 hours of culture, thiazoline blue (Thiazoline blue) was added and cultured for another 4 hours. After the culture solution was completely removed, the stop solution was added to each well of the microplate and stirred for 5 minutes, and then the absorbance was measured at a wavelength of 570 nm. The control group was added with 10% Fetal Bovine Serum (FBS) medium in the same amount as the amount of the sample, and the cell proliferation rate of the experimental group to which the sample was added was calculated by setting the cell proliferation of the control group to 100% while performing synchronous culture under the optimal condition for cell growth.
The cell growth effect was calculated by the following calculation formula 1, and the results are shown in table 2 below.
TABLE 2
As shown in table 2, it was confirmed that the rice, reed, corn silk, malva sylvestris, aloe extract, and the mixture a and the mixture B prepared in examples 1 to 7 were not cytotoxic at all concentrations.
Experimental example 2 skin moisturizing and improving effects
1) Experimental method
Skin moisture improvement conditions before, after 2 weeks and after 4 weeks application were examined using a skin moisture meter Corneometer CM 820 (Courage + Khazaka, germany) for 4 weeks using 25 subjects (male and female 25-50 years old) whose cheeks and all of the cosmetic formulations prepared according to table 1 were coated 2 times a day on both sides of the face of the subject, and the units were represented by Arbitrary units (Arbitrary Unit, AU) given by an instrument, and the higher the examination value, the higher the moisture content on the skin surface.
2) Results of the experiment
The results of the experiments relating to the improvement of skin moisturization are shown in table 3 below.
TABLE 3
As shown in table 3 above, the moisturizing effects of the cosmetic compositions prepared in preparation examples 1 to 7 and comparative examples 1 to 2 were examined, and as a result, it was confirmed that the moisturizing effects of the rice extract, the reed extract, the corn silk extract, the mallow extract, the aloe extract, and the preparation examples 1 to 7 in which they were mixed and extracted were higher than those of comparative examples 1 to 2. In particular, it was confirmed that the mixed extract B of preparation example 7 was more excellent in moisturizing effect than the extraction raw materials of preparation examples 1 to 6.
EXAMPLE 3 evaluation of amount of percutaneous Water loss
1) Experimental methods
The upper arm part of 25 subjects (male and female aged 20 to 50) was set as a detection part and the longitudinal direction was 2X 2cm 2 The cosmetic compositions of preparation examples 1 to 7 and comparative examples 1 to 2 in table 1 were examined after the test site was expressed by the size of (b). The test sites were carefully rubbed after application of the cosmetic composition and the amount of transdermal moisture loss was measured using TEWAMETER TM210 (C + K electronic gmh, germany). The short-term moisturizing effect was evaluated by measuring the moisture increase (%) at 30 minutes after application, 4 days after application, and 8 days after application, based on the moisture retention amount 0 hour before application. For measurement, the amount of percutaneous moisture loss was measured 3 times continuously by vertically contacting and holding the probe (probe) horizontally for 60 seconds. Measurements were made in the same manner in a constant temperature and humidity chamber, with higher values indicating greater moisture loss.
2) Results of the experiment
The results of the transdermal water loss amount are shown in table 4 below.
TABLE 4
As shown in table 4, the results of comparing the amounts of percutaneous moisture loss of preparation examples 1 to 7 and comparative examples 1 to 2 in 8 days confirmed that the amount of percutaneous moisture loss of preparation example 7 was the most improved with time. In particular, it was confirmed that the mixed extract B of preparation example 7 was more excellent in moisturizing effect than the extraction raw materials of preparation examples 1 to 6.
Experimental example 4 sedative Effect against skin irritant substance
1) Experimental methods
The skin calming effect was confirmed by a human skin information test on 25 male and female adults aged from 20 to 50 years, who had no skin disease or allergic symptoms and had no history of allergic reactions.
To the cosmetics and control samples of the above-mentioned preparation examples 1 to 7 and comparative examples 1 to 2, 5% lactic acid was added as a skin irritant, and then skin patch tests were performed, respectively. Before the sedation test, the forearm of the test subject was thoroughly wiped on the inner side with 70% ethanol and then completely dried, and 9 kinds of cosmetics each 30 μ g were applied to the patch. After 24 hours based on the patch time point, the patch was removed for about 30 minutes, and the patch portion was observed with a magnifier (MicroView) to confirm the presence or absence of erythema and edema. The evaluation was performed by using the criteria shown in table 5 below, and the average skin reactivity was calculated according to the following equation 2. The results are shown in Table 6 below.
TABLE 5
| Marking | Score of | Skin reactions | Evaluation criteria |
| - | 0 | Has no irritation | No reaction |
| ± | 0.5 | Micro-stimulation | Blurred or only perceptible slight erythema |
| + | 1 | Mild stimulation | Faint erythema with obvious border |
| ++ | 2 | Middle stimulation | Marked erythema |
| +++ | 3 | Strong stimulation | Severe erythema and bulla |
Mathematical formula 2
2) Results of experiments)
The results of the skin calming effect are shown in table 6 below.
TABLE 6
From the results of table 6 above, it was confirmed that the skin calming effect by lactic acid-induced irritation was superior in production examples 1 to 7 as compared with the control sample, and on the contrary, there was no difference from the control sample in the case of comparative examples 1 to 2. Further, it was confirmed that the synergistic effect was exhibited when the rice extract, the reed extract, the corn silk extract, the malva sylvestris extract and the aloe extract were mixed, as compared with the cases of the preparation examples 6 to 7 and the preparation examples 1 to 5, and it was confirmed that the skin-calming effect was more excellent when the rice extract, the reed extract, the corn silk extract, the malva sylvestris extract and the aloe extract were mixed at the same ratio as that of the preparation example 6 and the preparation example 7.
Experimental example 5 confirmation of radical scavenging Effect
1) Experimental methods
The effect on the elimination of Free radicals (Free radial) was confirmed by using the extracted dry powders of examples 1 to 7. In order to confirm the effect on the elimination of Free radicals (Free radial), experiments were performed as follows.
Experiments were carried out using the 1, 1-diphenyl-2-trinitrophenylhydrazine (DPPH) method (see: blois. M.S. Nature 181,1190, 1958), and 1, 1-diphenyl-2-trinitrophenylhydrazine and Quercetin (Quercetin) were obtained from SIGMA corporation. 2ml of each of examples 1 to 7 and the positive control group at different concentrations (8 ppm, 16ppm, 48ppm, 80 ppm) were added to 1ml of a 0.2mM 1, 1-diphenyl-2-trinitrophenylhydrazine solution in methanol and stirred, followed by reaction at room temperature for 10 minutes. Then, the absorbance was measured at a wavelength of 517nm, and in this case, pure water was used instead of each sample as a blank test.
The change in the radical was measured by the following equation 3, and the results are shown in Table 5.
2) Results of the experiment
The results of radical elimination are shown in Table 7 below.
TABLE 7
As shown in table 7, it was confirmed that examples 1 to 7 were all effective for radical elimination. In particular, it was confirmed that examples 6 to 7 are higher in antioxidant effect than examples 1 to 5, wherein the effect of example 7 is most excellent.
EXAMPLE 6 inhibition of tyrosinase Activity
1) Experimental method
The inhibition test of Tyrosinase (Tyrosinase) activity was carried out by Yagi or the like, which is a test for confirming the effect of inhibiting melanin activity of a substance concerned, and which is measured by a dopachrome method.
In this experiment, a reaction solution was prepared by adding 40. Mu.l of 1.5mM L-Tyrosine (L-Tyrosine) solution to 120. Mu.l of 0.1M phosphate buffer (phosphate buffer pH 6.5) in a 96-well culture plate, and after 5 minutes of reaction after 10. Mu.l of the sample solution was added to the reaction solution, 10. Mu.l of mushroom tyrosinase (100 unit/ml) was added to conduct an enzymatic reaction at 37 ℃ for 10 minutes. After 10 minutes, the generated DOPACr in the reaction solution was measured at a wavelength of 490nm using a microplate counter.
The tyrosinase activity inhibition rate was calculated by the following formula 4, and the results are shown in the following table 8.
Mathematical formula 4
TABLE 8
It was confirmed that examples 1 to 7 each showed a progressive effect of inhibiting tyrosinase activity depending on the concentration, and it was confirmed that the effect was increased as compared with examples 1 to 5 when the raw materials were mixed as in examples 6 to 7. In particular, as shown in table 8, when the raw materials were mixed in the same ratio as in example 7, a synergistic effect was exhibited in which the effect was further increased, and it was found that the compound was effective for inhibiting the enzymatic activity of tyrosinase.
EXAMPLE 7 blocking melanin Synthesis
1) Experimental method
B16F10 mouse melanoma cells at 3.5X 10 5 Cell/well concentration was divided into 6-well plates and cultured for 24 hours, and then each well was treated with α -melanocyte stimulating hormone (α -MSH) and samples of examples, preparation examples, and comparative examples prepared at different concentrations, respectively. After 48 hours of culture, the medium was removed by washing 2 times with Phosphate Buffer Solution (PBS), and the adherent cells were transferred to an E-P tube and centrifuged to obtain cultured cell pellets (pellet). The shape of the precipitated B16F10 melanoma cells was photographed, and after melanin was dissolved at a temperature of 60 ℃ for 1 hour using a 1N NaOH solution supplemented with dimethyl sulfoxide (DMSO), the absorbance was measured at a wavelength of 405nm after dispensing 200. Mu.l per well of a 96-well culture plate.
The melanin synthesis inhibition ratio was calculated by the following equation 5, and the results are shown in table 9 below.
It was confirmed that examples 1 to 7 all inhibited melanin synthesis depending on the concentration. In particular, it was confirmed that when the mixed rice, reed, corn silk, malva sylvestris and aloe in examples 6 to 7 were extracted, the melanin synthesis inhibitory effect was more increased than when the single extracts were used as in examples 1 to 5.
EXAMPLE 8 examination of anti-inflammatory Effect by suppressing NO production
1) Experimental method
Raw 264.7 cells as mouse macrophages were plated at 3.5X 10 5 The concentration of cells/well was divided into 6-well plates and cultured for 24 hours. Then, the culture medium of each well was replaced with the sample cell culture medium prepared in example 1 to example 7 containing the dilution at the concentration according to table 10. Each well was treated with 1 μ g of Lipopolysaccharide (LPS) as a stimulus and cultured for 24 hours. Mu.l of each supernatant was transferred to a 96-well plate, 100. Mu.l of each Griess solution was added thereto, and the reaction was carried out at room temperature for 10 minutes, and the NO inhibitory effect was judged by measuring the absorbance at a wavelength of 540nm, and the results are shown in Table 10 below.
It was confirmed that examples 1 to 7 all had the effect of inhibiting NO production depending on the concentration. In particular, it was confirmed that the effect of inhibiting NO generation was more increased when the mixed rice, reed, corn silk, mallow and aloe of examples 6 to 7 were extracted than when they were used alone as in examples 1 to 5.
Hereinafter, based on the results of the above experimental examples, it is suggested that the following cosmetics are combined with mixed extracts including rice extract, reed extract, corn silk extract, malva sylvestris extract, aloe extract, and the like.
However, the composition of the present invention is not limited to the following formulation examples.
Formulation example 1 preparation of a cosmetic lotion containing mixed extracts of rice, reed, corn silk, malva sylvestris and aloe vera
The formulation of lotions (skin care creams and lotions) for cosmetics containing the mixed extracts of rice, reed, corn silk, malva sylvestris and aloe in example 7 is shown in table 11.
TABLE 11
The preparation method comprises the following steps: adding items 2, 3, 4 and 8 in sequence to item 11, stirring for dissolution, heating item 5 to about 60 ℃ for dissolution, adding item 10 for dissolution, and adding item 11. Finally, after the addition of items 6, 7 and 9, item 1 was added and sufficiently stirred and then aged.
Formulation example 2 preparation of nutritional emulsion comprising mixed extracts of rice, reed, corn silk, malva sylvestris and aloe vera
The formulation of the nutritional emulsion in cosmetics comprising the mixed extract of rice, reed, corn silk, malva sylvestris and aloe of example 7 is shown in table 12.
TABLE 12
The preparation method comprises the following steps: mixing items 10, 11, 12, 13 and 16, heating to 80-85 ℃ while stirring, then putting into a preparation kettle, starting an emulsifier, heating items 2, 3, 4, 5, 6, 7, 8, 9 and 12 to 80-85 ℃, dissolving and emulsifying. After the completion of the emulsification, the mixture was stirred with a stirrer and cooled to 50 ℃ and then the mixture was added in item 15, cooled to 45 ℃ and then item 14, and at a temperature of 35 ℃ item 1 was added and cooled to 25 ℃ and then aged.
Formulation example 3 preparation of a nourishing cream comprising mixed extracts of rice, reed, corn silk, malva sylvestris and aloe vera
The formulation of a nourishing cream in cosmetics comprising the mixed extract of rice, reed, corn silk, malva sylvestris and aloe of example 7 is shown in table 13.
Watch 13
The preparation method comprises the following steps: mixing items 12, 13, 14 and 16, heating to 80-85 ℃ while stirring, then placing into a preparation kettle, starting an emulsifier to heat items 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 to 80-85 ℃, dissolving, then adding item 15, stirring, and then placing into the preparation kettle for emulsification. Cooling to 35 deg.C with stirring after emulsification, adding the product of item 1, cooling to 25 deg.C, and aging.
Formulation example 4 preparation of essence containing mixed extracts of rice, reed, corn silk, malva sylvestris and aloe vera
The formula of the essence for cosmetics containing the mixed extract of rice, reed, corn silk, mallow and aloe of example 7 is shown in table 14.
TABLE 14
The preparation method comprises the following steps: the products of items 2, 3, 4, 5 and 6 are homogenized at a predetermined temperature and are referred to as nonionic amphiphilic lipids. Mixing the above nonionic amphiphilic lipid with the mixture of items 7, 8 and 14, further mixing in item 1, homogenizing at a predetermined temperature, passing through a high pressure homogenizer, then slowly adding item 9 at a predetermined temperature, homogenizing, and passing through a high pressure homogenizer again. Then adding the dispersing and stabilizing materials of items 10, 11, 12 and 13, and curing.
The present invention has been described above with reference to the drawings, but this is only one example of various embodiments including the gist of the present invention, and the present invention is not limited to the above-described example because it is intended to enable a person having ordinary skill in the art to easily carry out the present invention. Therefore, the scope of the present invention should be construed as being indicated by the appended claims, and all technical ideas that are equivalent thereto by way of change, substitution, replacement, etc. within the scope not departing from the gist of the present invention are included in the claims of the present invention. Further, it should be understood that some of the structures in the drawings are provided in an exaggerated or reduced form as compared with the actual structures for more clear explanation.
Claims (4)
1. A cosmetic composition for skin protection, characterized by comprising a mixed extract obtained by mixing rice, reed, corn silk, malva sylvestris and aloe as an active ingredient.
2. The cosmetic composition for skin protection according to claim 1, comprising oryza sativa, reed, corn silk, mallow and aloe vera, and having skin moisturizing, calming, antioxidant, whitening and anti-inflammatory activities, wherein the weight ratio of the combination of oryza sativa, reed, mallow and aloe is 0.1-40.0: 0.1-40.0.
3. The cosmetic composition for skin protection according to claim 1, which comprises Oryza sativa, phragmites communis, stigma Maydis, malva sylvestris and Aloe vera, and has skin moisturizing, tranquilizing, antioxidant and whitening activities, wherein the extract is extracted with one or more extraction solvents selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, ethyl acetate, glycerin and ethylene glycol.
4. The cosmetic composition for skin protection according to claim 1, comprising rice, reed, corn silk, mallow and aloe vera, having skin moisturizing, calming, antioxidant and whitening activities, wherein the cosmetic composition is formulated in the form of a lotion, a skin care cream, an emulsion, a cream, a foundation, an essence, a gel, a pack, an emulsion sunscreen cream, an emulsion foundation, an emulsion pre-makeup cream, an oil cake foundation, a dry-wet dual-purpose cake or a cake.
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| KR10-2021-0044571 | 2021-04-06 |
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| CN116473901A (en) * | 2023-06-12 | 2023-07-25 | 广州丽彦妆生物科技有限公司 | Moisturizing and repairing freeze-dried mask and preparation method thereof |
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