CN1778339B - Drug drop pills for treating angina pectoris of coronary heart disease - Google Patents

Abstract

The invention discloses a traditional Chinese medicine dripping pill for treating angina pectoris of coronary heart disease, which uses salvia miltiorrhiza, notoginseng, borneol and ginseng or codonopsis as raw materials, and the preparation process steps are as follows: (1) mixing salvia miltiorrhiza, notoginseng and ginseng or codonopsis Or make water extract or ethanol extract separately; (2) carry out preliminary clarification treatment to described extract; (3) further carry out ultrafiltration to described extract; (4) ultrafiltrate is concentrated, Add borneol to make drop pills.

Description

Drug drop pills for treating angina pectoris of coronary heart disease

technical field

The invention relates to a traditional Chinese medicine prepared by an ultrafiltration process. Specifically, the invention relates to a traditional Chinese medicine dripping pill prepared by an ultrafiltration process.

Background technique

Membrane separation technology (Membrane Separation Technique) is a new high-efficiency separation technology, which has been internationally recognized as the most promising high-tech production technology from the end of the 20th century to the middle of the 21st century. Ultrafiltration (UF) technology is a membrane separation technology whose basic principle is to use the selective screening performance of membrane pores to separate, purify and concentrate substances. The ultrafiltration method uses an anisotropic membrane (that is, an asymmetric membrane) made of polymer materials as the filter medium. Under normal temperature conditions, relying on a certain pressure and flow rate, the solution flows through the membrane surface, forcing low molecular weight substances to permeate. Through the membrane, the polymer substances are intercepted.

Because the ultrafiltration method is a physical method, it has the characteristics of no need for repeated heating, no "phase state" change, less possibility of destroying active ingredients than other general methods, and short process flow, so it is applied to the research of extracting active ingredients of traditional Chinese medicine It is becoming more and more active, and some products have moved from laboratory research to industrial production. Wang Shiling and others in the PLA 304 Hospital used ultrafiltration to extract the active ingredient baicalin in Scutellaria baicalensis. The results showed that the ultrafiltration method was better than the conventional method in terms of yield and purity. And once ultrafiltration can meet the requirement of injection, no further refinement is needed, the process is simple, and the production cycle can be shortened by 1 to 2 times (Wang Shiling, Zheng Dianbao "Preliminary investigation of extracting baicalin by ultrafiltration", Chinese patent medicine research, 1988 (3 ): 5). Wang Shiling and others have further studied the optimal process conditions for extracting baicalin by ultrafiltration. The experimental results prove that the ultrafiltration membrane with suitable pore size (molecular weight cut-off is 6000～10000) is the best way to improve the yield and quality of baicalin. The key is to increase the temperature of the liquid medicine or reduce the concentration at the same time, and strictly control the pH value (pH=1.5 during acidification, pH=7.0 during alkali dissolution), which can significantly increase the ultrafiltration speed and obtain the best output effect (Wang Shiling, "Ultrafiltration A study on the process of extracting baicalin at one time", Chinese patent medicine, 1994, 16 (3): 2). Xu Jinlin et al. used ultrafiltration (polysulfone membrane, molecular weight cut-off 6000) in the preparation of phytic acid, and the yield of phytic acid It is 86.4%, 12.6% higher than the conventional phytate method, and the phytic acid obtained by the ultrafiltration method almost does not contain inorganic phosphorus, and the appearance is transparent and almost colorless (Xu Jinlin, Xu Jie, Wang Yuanjin "Research on the Preparation of Phytic Acid by Membrane Separation Technology" , Chinese Journal of Pharmaceutical Industry, 1994, 25 (4): 150). He Changsheng and other applications of ultrafiltration technology to separate and refine stevioside, using ultra-thin plate ultrafilter and cellulose acetate membrane (CA membrane) with a molecular weight cut-off of 10000 ) field experiments on stevioside purification, the process flow is reasonable and feasible. The performance of the ultrafilter is stable, the decolorization performance of the membrane and the effect of removing impurities are good, and it can better solve the precipitation and potting that often occur in the production of stevioside. Foaming problem (He Changsheng, Wang Bingnan, Zhu Shanshan "Research on the application of stevioside ultrafiltration", Water Treatment Technology, 1994, 20(2): 89). Huang Ziqiang used ultrafiltration membranes (molecular weight cut-offs of 4000 and 10000 Compared with the bleaching method, recrystallization method, alcohol ether precipitation method and basic salt precipitation method that are mostly used in China, the ultrafiltration process is simple, efficient, and low in cost. Oils, pigments, sugars and other highly hydrophilic impurities in the water can achieve the desired effect (Huang Ziqiang, "Preliminary Study on the Purification of Camellia Camellia Saponin by Ultrafiltration Membrane Method", Water Treatment Technology, 1995, 21(2): 99). Guo Liwei from Nanjing University of Traditional Chinese Medicine compared and studied the effects of water-alcohol method and ultrafiltration method on the clarification of Cornus officinalis preparations on the ingredients contained in the preparations. The ultrafiltration membrane has no obvious effect on loganin (molecular weight is 384), but the membrane with a molecular weight cut-off of 1000 makes loganin lose about 50% Right (Guo Liwei, Peng Guoping, Pan Yang, etc. "Comparative research on refining traditional Chinese medicine preparations containing Cornus officinalis by water-alcohol method and membrane separation method", Chinese Patent Medicine, 1999, 21 (2): 59). Wang Chengzhang et al. Sulfone membrane, molecular weight cut-off 30000) and polyamide resin adsorption and elution method are used to separate and purify the ethanol extract of Ginkgo biloba leaves. After detection by high performance liquid chromatography (HPLC), the content of glycosides in Ginkgo biloba is about 45%, and the yield is 0.5% %～0.7%, compared with conventional steam distillation method, organic solvent extraction method is superior, and can reduce waste water discharge in ultrafiltration process, protect environment, reduce production cost, improve economic benefit (Wang Chengzhang etc. " ultrafiltration is in purifying ginkgo The application of lutein glycosides", Forestry Science and Technology Communication, 1997, (2): 21).

Although the application of ultrafiltration technology in the production of traditional Chinese medicine preparations has its unique advantages, the extent of its application is still very limited. The reason is that there are still the following problems:

(1) The composition of Chinese herbal medicine is complex, especially in many compound preparations, the active ingredients have not been fully understood, so it needs to be thoroughly studied before applying ultrafiltration technology to Chinese herbal medicine preparations. For example, due to the complexity of the components, it is impossible to apply ultrafiltration to the production of most traditional Chinese medicine preparations before a large number of pharmacological and clinical research tests are conducted to fully evaluate the effect of ultrafiltration on the efficacy of each component in traditional Chinese medicine preparations.

(2) There are few types of membrane materials, the membrane pore size distribution is wide, and the performance is not stable. The ultrafiltration membrane materials used in the production of traditional Chinese medicine preparations include cellulose acetate, polyacrylonitrile, polysulfone, sulfonated polysulfone, polysulfone amide, etc. According to its affinity to water, it can be roughly divided into two categories: hydrophobic membrane materials and hydrophilic membrane materials. Hydrophilic membrane materials such as cellulose acetate and sulfonated polysulfone have less adsorption of solutes and a smaller molecular weight cut-off, but poor thermal stability, mechanical strength, chemical resistance, and bacterial erosion resistance are usually not high; polysulfone and other hydrophobic Membrane material has high mechanical strength, high temperature resistance, solvent resistance, and biodegradation resistance, but because the molecular chain contains a large number of hydrophobic genes or chain links, and has a lot of electrostatic charges, the membrane has a low water permeability and low anti-pollution ability .

(3) Membrane fouling is the biggest obstacle preventing ultrafiltration technology from laboratory research to industrial application. In the ultrafiltration process of traditional Chinese medicine preparations, if the pretreatment effect of the liquid medicine is not good, the membrane surface will be easily polluted and the membrane pores will be blocked, which will reduce the permeation flux, that is, the productivity, or even fail to work normally, reduce the production efficiency, and increase the cost, resulting in membrane shortened service life.

(4) The selection method of membrane modules has not been established yet, and the operating parameters of ultrafiltration still need to be optimized. There are many factors that affect the effect of ultrafiltration, including the selection of membrane components, the determination of process parameters and the cleaning method of the ultrafilter after use. Therefore, the ultrafiltration equipment and operating technology suitable for ultrafiltration of traditional Chinese medicine systems need further research.

After long-term and unremitting efforts, the inventor determined the appropriate process operating conditions by analyzing a large number of experimental data, and provided a specific solution for the industrial production of the drug of the present invention by ultrafiltration.

Contents of the invention

The object of the present invention is to provide a medicine dropping pill for treating angina pectoris of coronary heart disease.

The present invention is implemented through the following schemes:

The present invention is realized through the following technical steps: using salvia miltiorrhiza, notoginseng, ginseng and borneol as raw materials, the preparation is carried out according to the following steps:

(1) Mix salvia miltiorrhiza, Panax notoginseng, and ginseng to make water extract or alcohol extract;

(2) Carry out preliminary clarification treatment to described extract;

(3) further carry out ultrafiltration treatment to described extract;

(4) Concentrate the ultrafiltrate into an extract; mix the obtained extract with borneol and auxiliary materials evenly, and make a drop pill preparation.

The ratio of the above-mentioned raw materials is calculated by weight: 20-97 parts of Danshen, 2-79 parts of Panax notoginseng, 0.2-3 parts of Borneolum, 10-40 parts of Radix Ginseng; 2.0, ginseng 15-30; more preferably: salvia miltiorrhiza 75.2-90, Sanqi 9-23.5, borneol 0.5-1.3, ginseng 20-25.

The above-mentioned raw material ginseng can be replaced by Codonopsis ginseng, that is, the above-mentioned raw material drug can be Danshen 20-97, Sanqi 2-79, Borneol 0.2-3, Codonopsis 10-40; preferably: Danshen 63.0-94.0, Sanqi 4.0-35.0, Borneol 0.5-2.0, Codonopsis 15-30; more preferably: Danshen 75.2-90, Panax notoginseng 9-23.5, Borneol 0.5-1.3, Codonopsis 20-25.

In the technical step (1) of the present invention, the alcohol extract can be lower alcohols of different concentrations such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, etc., or extracts of their mixtures. The alcohol extract can be subjected to the next preliminary clarification treatment without concentration or after proper concentration.

In the technical step (2) of the present invention, preliminary clarification treatment can carry out rough filtration with general material such as gauze, silk silk etc., also can carry out microfiltration with more professional material such as ceramic membrane, also can get supernatant after high-speed centrifugation Liquid, also can use flocculant such as chitosan flocculation clarifier, 101 fruit juice clarifier, ZTC1+1 natural clarifier, egg white flocculant etc. Some impurities. The above clarification methods can be used alone or in combination, such as coarse filtration-adsorption clarification, adsorption clarification-high-speed centrifugation, coarse filtration-microfiltration, coarse filtration-alcohol precipitation, etc. The solution that has been preliminarily clarified can be subjected to the next step of ultrafiltration without concentration or after being properly concentrated; preferably, the next step of ultrafiltration is performed without concentration.

In the technical step (3) of the present invention, the ultrafiltration membrane used for ultrafiltration can be cellulose diacetate membrane (CA), cellulose triacetate membrane (CTA), cyanoethyl cellulose acetate membrane (CN-CA), polyester Sulfone membrane (PS), sulfonated polysulfone membrane (SPS), polyethersulfone membrane (PES), sulfonated polyethersulfone membrane (SPES), polysulfone amide membrane (PSA), phenolphthalein side group polyarylsulfone membrane (PDS) ), polyvinylidene fluoride film (PVDF), polyacrylonitrile film (PAN), polyimide film (N), cellulose film, methyl methacrylate-acrylonitrile copolymer film (MMA-AN), poly Acrylonitrile/cellulose diacetate (PAN/CA) blend membranes, dynamically formed ultrafiltration membranes, and modified membranes of the above membranes. Preferably cellulose diacetate membrane (CA), cellulose triacetate membrane (CTA), polysulfone membrane (PS), sulfonated polysulfone membrane (SPS), polyethersulfone membrane (PES), sulfonated polyethersulfone membrane (SPES), polysulfoneamide membrane (PSA), polyvinylidene fluoride membrane (PVDF), polyacrylonitrile membrane (PAN).

The molecular weight cut-off of the ultrafiltration membrane is generally 6000-80000, preferably 10000-70000, most preferably 20000-50000.

Ultrafiltration can be either cross-flow filtration or dead-end filtration, but cross-flow filtration is preferred.

The operating conditions of the ultrafiltration process are as follows:

(1) The inlet pressure of the ultrafiltration is 0.1-0.5MPa, preferably 0.1-0.35Mpa, and most preferably 0.25-0.35Mpa; the outlet pressure of the ultrafiltration is 0.5-0.25kPa lower than the inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.1-0.2Mpa.

(2) The flow rate of the feed liquid is 1.0-4.0 m/s, preferably 2.0-3.0 m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unsteady flow in the membrane channel, and the flow velocity fluctuation difference is 1.0-2.0m/s.

(3) In the ultrafiltration system, high-pressure inert gas such as nitrogen is fed intermittently to form a gas-liquid pulse flow, and the cycle is 0.5h-2h to ventilate once, each time for 1 minute.

(3) The feed liquid temperature is 15-50°C, preferably 20-40°C.

(4) When the stock solution is concentrated by 1/15 to 1/5, add water or dilute alcohol solution for ultrafiltration 1 to 2 times; preferably when the stock solution is concentrated by 1/12 to 1/8, add water Or dilute alcohol solution ultrafiltration 1 to 2 times.

(5) The pH value of the feed liquid is controlled at 5 to 9, preferably 6.0 to 7.5;

(6) Backwashing conditions: Backwashing pressure is 0.15-2.5MPa, backwashing cycle is 0.5-1.5h, and backwashing time is 1min-10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time To carry out, generally work for 10 to 20 minutes, and recoil for 30 seconds to 3 minutes.

(7) The chemical cleaning cycle is 0.5 months to 2 months. The chemical cleaning agents are generally dilute acids, dilute alkalis, and surfactants, preferably dilute alkalis such as 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and The mixed solution of 2% sodium hypochlorite, etc., the pH value is 10-12, and the cleaning working pressure is 0.05-1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

In the ultrafiltration process, periodic pressure fluctuations or periodic flow fluctuations or periodic inert gas injections can be used alone, or in combination, that is, periodic pressure fluctuations and periodic flow fluctuations are used in combination, or periodic pressure fluctuations It is used in combination with periodic inert gas injection, or in combination with periodic flow fluctuations and inert gas injection, or in combination with the three.

In the technical step (4) of the present invention, after the ultrafiltrate is concentrated into an extractum, after mixing evenly with borneol and auxiliary materials, the chemical material is heated, moved into the dropping tank of the dropping pill machine, and the medicinal liquid is dropped into low-temperature liquid paraffin to remove the liquid Paraffin, choose pills.

Among them: the auxiliary material is polyethylene glycol-6000, its freezing point is 53-58 °C, and the addition amount is 2-6 times the weight of the extract and borneol; the temperature of the chemical material is 60-100 °C; the temperature of the liquid paraffin is 0-10 °C. ℃ (optimally 5-10 ℃); pellet weight 5-50mg/granule, diameter 1.95-4.29mm.

Experimental example Clinical curative effect observation of drug treatment of coronary heart disease angina pectoris according to the present invention

1 clinical data

According to the clinical diagnostic criteria of ischemic heart disease and angina pectoris stipulated by WHO, they were randomly divided into two groups. Group A: 100 cases, aged 52-70 years, with an average age of 59.4 years; Group B: 100 cases, aged 50-68 , with an average age of 57.

2 drugs and methods

Two groups of patients carry out general physical examination, after electrocardiogram inspection and laboratory examination, the treatment group throws 250mg of medicine of the present invention, every day 3 times orally, and the course of treatment is 3 months, and the matched group throws each 4 pieces of compound salvia miltiorrhiza tablets, every day Oral administration three times, the type of angina pectoris in the control group was similar to that in the treatment group. Observation method: During the treatment period, the two groups of patients stopped using all drugs that improve microcirculation and reduce cardiac oxygen consumption. For patients with frequent angina pectoris, they took nitroglycerin tablets under the tongue to relieve symptoms. An electrocardiogram was performed once every half month. During the treatment period, the analgesic effect of the two groups of drugs, the relief of symptoms, the changes of the electrocardiogram and the changes of heart rate, blood pressure, and liver and kidney functions were closely observed.

3 Curative effect evaluation criteria and results

Markedly effective: symptoms of chest tightness and precordial pain disappeared completely, and ST-T changes in ECG returned to normal; effective: symptoms of chest tightness and precordial pain were relieved, the number of attacks decreased, and S-T changes in ECG showed a certain degree of recovery; invalid: symptoms did not improve , no change in ECG.

4 results

Angina relief degree and ECG changes are shown in the attached table.

Angina pectoris and electrocardiogram improvement of the two groups of patients in the attached table (n=100)

Heart rate, blood pressure and liver and kidney function of the two groups of patients had no significant changes.

Detailed ways

The present invention will be further elaborated below in conjunction with embodiment. These examples are for illustrative purposes only and do not limit the invention in any way.

Embodiment one

The raw materials are 37.5g of Danshen, 11.8g of Sanqi, 0.8g of borneol, and 10.0g of ginseng.

Extract Danshen, Panax notoginseng and Ginseng with ethanol to obtain the ethanol extract of their mixed medicinal materials, filter the extract with gauze, and collect the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30sec. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix them evenly with 18g of polyethylene glycol-6000, heat to a temperature of 85°C, and after 20-120 minutes to make the material, move it to a dropping tank of a dripping machine whose tank temperature is kept at 85-90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment two

The raw materials used are Danshen 46.5g, Panax notoginseng 3.0g, Borneol 0.8g, and Ginseng 8.5g.

Decoct coarsely crushed salvia miltiorrhiza and ginseng with 5 times the amount of water for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrates to obtain salvia miltiorrhiza Ginseng extract. Extract the notoginseng with 70% ethanol to obtain the notoginseng extract. The above-mentioned Danshen ginseng extract and Panax notoginseng extract were combined, allowed to stand, and filtered. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the raw liquid of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix them evenly with 20g of polyethylene glycol-6000, heat to a temperature of 85°C, and after 20-120 minutes to make the material, move it to a dropping tank of a dripping machine whose tank temperature is kept at 85-90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment three

The raw materials are 26.0g of Salvia miltiorrhiza, 16.5g of Sanqi, 0.7g of borneol, and 17.0g of ginseng.

Extracting Danshen, Panax notoginseng and Panax ginseng with ethanol to obtain a mixed ethanol extract, centrifuging the extract at high speed and then separating the supernatant. The liquid is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1/8, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix evenly with 20g of polyethylene glycol-6000, heat to a temperature of 60°C, and after 20 to 120 minutes of compounding, move to a dropping tank of a dripping machine whose tank temperature is kept at 90°C. Drop the drug solution into methyl silicone oil at 7-8°C, take out the dropping pills, remove the oil, select the pills through a screen, and make 1000 dropping pills, to get ready.

Embodiment four

The raw materials are 49.0 grams of Danshen, 8.4 grams of Radix Notoginseng, 0.6 grams of Borneolum, and 6.0 grams of Radix Ginseng.

Add coarsely crushed salvia miltiorrhiza, notoginseng and ginseng to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30sec. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix evenly with 21g of polyethylene glycol-6000, heat to a temperature of 60°C, and after 20 to 120 minutes of compounding, move to a dropping tank of a dropping pill machine whose tank temperature is kept at 90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment five

24.2 grams of salvia miltiorrhiza, 25.5 grams of notoginseng, 0.4 grams of borneol, and 10.0 grams of ginseng were used as raw materials.

Add coarsely crushed salvia miltiorrhiza, notoginseng and ginseng to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the raw liquid of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32 to 1.40 (55° C.), take the extract and borneol, mix with 20 g of polyethylene glycol-6000, heat to a temperature of 60° C. After 120 minutes, move to the dripping tank of the dropping pill machine where the tank temperature is maintained at 90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment six

16.2 grams of salvia miltiorrhiza, 29.5 grams of notoginseng, 0.4 grams of borneol, and 13.8 grams of ginseng were used as raw materials.

Add coarsely crushed Danshen, Panax notoginseng and ginseng medicinal materials into the extraction tank, add 0.89g sodium bicarbonate, add 5 times the amount of water, decoct for 2 hours, filter, and carry out the second extraction of the filter residue, add 4 times the amount of water , fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the liquid inlet of the ultrafiltration The pressure is 0.35Mpa, and the outlet pressure of the ultrafiltration is 0.20kPa lower than the pressure of the inlet. The ultrafiltration adopts a lower pressure at the beginning, and then slowly increases the pressure; The flow rate of the feed liquid is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The flow rate fluctuation difference is 2.0m/s. In the ultrafiltration system Nitrogen gas is fed intermittently to form a gas-liquid pulse flow. The period is 2 hours, and the gas is ventilated once every time. , the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. Carry out normal ultrafiltration and divert a part of the filtrate to backflush the ultrafiltration membranes of another set or several sets of components, exchange after a period of time, work for 20 minutes, and backwash for 3 minutes. The chemical cleaning cycle is 2 months, and the chemical cleaning agent It is a mixed solution of 0.5% ~ 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 ~ 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaning agent, rinse with water to the middle sex.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32 to 1.40 (55° C.), take the extract and borneol, mix it with polyethylene glycol-6000 18 g, heat to a temperature of 85° C. After 120 minutes, move to the dropping tank of the dropping pill machine whose tank temperature is kept at 85-90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment seven

The raw materials are 37.5g of Danshen, 11.8g of Radix Notoginseng, 0.8g of Borneol and 10.0g of Codonopsis.

Extract Danshen, Panax notoginseng and Codonopsis pilosula with ethanol to obtain the ethanol extract of their mixed medicinal materials, filter the extract with gauze, and collect the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30sec. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix them evenly with 18g of polyethylene glycol-6000, heat to a temperature of 85°C, and after 20-120 minutes to make the material, move it to a dropping tank of a dripping machine whose tank temperature is kept at 85-90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment eight

The raw materials are Danshen 46.5g, Sanqi 3.0g, Borneol 0.8g, Codonopsis 8.5g.

Decoct the coarsely crushed Salvia miltiorrhiza and Dangshen with 5 times the amount of water for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrates to obtain Salvia miltiorrhiza Codonopsis extract. Use 70% ethanol to extract Panax notoginseng to obtain Panax notoginseng extract. Combine the above-mentioned Danshen Codonopsis extract and Panax notoginseng extract, let stand, and filter. The filtrate is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000 , the filtration method adopts dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. The initial stage of the ultrafiltration adopts a lower pressure , and then slowly increase the pressure; in the ultrafiltration process, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. To generate pulsating flow or unstable flow, the fluctuation difference of flow velocity is 2.0m/s, nitrogen gas is fed intermittently in the ultrafiltration system to form a gas-liquid pulse flow, and the cycle is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C , when the stock solution of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel and use the method of alternate backflushing, one or several sets of them perform normal ultrafiltration and part of the filtrate is flowed out to backflush the ultrafiltration membrane of another set or several sets of components, with a period of time interval After the exchange, work for 20 minutes and backwash for 3 minutes. The chemical cleaning cycle is 2 months, and the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, and the pH value is 10 to 12. The working pressure of cleaning is 1.0MPa. After cleaning with chemical cleaning agent, rinse with water to near neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix them evenly with 20g of polyethylene glycol-6000, heat to a temperature of 85°C, and after 20-120 minutes to make the material, move it to a dropping tank of a dripping machine whose tank temperature is kept at 85-90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment nine

The raw materials are 26.0g of Danshen, 16.5g of Sanqi, 0.7g of borneol, and 17.0g of Codonopsis.

Extract Danshen, Panax notoginseng and Codonopsis pilosula with ethanol to obtain a mixed ethanol extract, centrifuge the extract at high speed and separate the supernatant. The liquid is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The flow rate fluctuation difference is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1/8, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets of them perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix evenly with 20g of polyethylene glycol-6000, heat to a temperature of 60°C, and after 20 to 120 minutes of compounding, move to a dropping tank of a dripping machine whose tank temperature is kept at 90°C. Drop the drug solution into methyl silicone oil at 7-8°C, take out the dropping pills, remove the oil, select the pills through a screen, and make 1000 dropping pills, to get ready.

Embodiment ten

The raw materials are 49.0 grams of Danshen, 8.4 grams of Radix Notoginseng, 0.6 grams of Borneolum, and 6.0 grams of Codonopsis pilosula.

Add coarsely crushed Danshen, Panax notoginseng and Codonopsis pilosula to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , the filter residue is discarded, and the filtrate is combined. The filtrate is ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the inlet pressure of the ultrafiltration is 0.1Mpa, The outlet pressure of the ultrafiltration is 0.5kPa lower than the inlet pressure. The ultrafiltration adopts a lower pressure in the initial stage, and then gradually increases the pressure; in the ultrafiltration process, the periodic pressure fluctuation is adopted, and the pressure fluctuation difference is 0.1Mpa. The liquid flow rate is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The flow rate fluctuation difference is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system. A gas-liquid pulse flow is formed, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the raw liquid of the feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the feed liquid The PH value is controlled at 5. The backwashing pressure is 0.15MPa, the backwashing cycle is 0.5h, and the backwashing time is 1min. Filter and divert a part of the filtrate to recoil the ultrafiltration membrane of another set or several sets of components, exchange after a period of time, work for 10 minutes, and recoil for 30 sec. The chemical cleaning cycle is 0.5 months, and the chemical cleaning agent is 0.5% to 4.0 The mixed solution of % sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaning agent, rinse with water until it is nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Take the extract and borneol, mix evenly with 21g of polyethylene glycol-6000, heat to a temperature of 60°C, and after 20 to 120 minutes of compounding, move to a dropping tank of a dropping pill machine whose tank temperature is kept at 90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment Eleven

24.2 grams of salvia miltiorrhiza, 25.5 grams of notoginseng, 0.4 grams of borneol, and 10.0 g of Codonopsis pilosula were used as raw materials.

Add coarsely crushed Danshen, Panax notoginseng and Codonopsis pilosula to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow velocity fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the original feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets of them perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32 to 1.40 (55° C.), take the extract and borneol, mix with 20 g of polyethylene glycol-6000, heat to a temperature of 60° C. After 120 minutes, move to the dripping tank of the dropping pill machine where the tank temperature is maintained at 90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Embodiment 12

The raw materials are 16.2 grams of Salvia miltiorrhiza, 29.5 grams of Sanqi, 0.4 grams of borneol, and 13.8 grams of Codonopsis pilosula.

Add coarsely crushed Danshen, Panax notoginseng and Codonopsis pilosula to the extraction tank, add 0.89g sodium bicarbonate, add 5 times the amount of water, decoct for 2 hours, filter, and carry out the second extraction of the filter residue, add 4 times the amount of water , fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the liquid inlet of the ultrafiltration The pressure is 0.35Mpa, and the outlet pressure of the ultrafiltration is 0.20kPa lower than the pressure of the inlet. The ultrafiltration adopts a lower pressure at the beginning, and then slowly increases the pressure; The flow rate of the feed liquid is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The flow rate fluctuation difference is 2.0m/s. In the ultrafiltration system Nitrogen gas is fed intermittently to form a gas-liquid pulse flow. The period is 2 hours, and the gas is ventilated once every time. , the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. Carry out normal ultrafiltration and divert a part of the filtrate to backflush the ultrafiltration membranes of another set or several sets of components, exchange after a period of time, work for 20 minutes, and backwash for 3 minutes. The chemical cleaning cycle is 2 months, and the chemical cleaning agent It is a mixed solution of 0.5% ~ 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 ~ 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaning agent, rinse with water to the middle sex.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32 to 1.40 (55° C.), take the extract and borneol, mix it with polyethylene glycol-6000 18 g, heat to a temperature of 85° C. After 120 minutes, move to the dropping tank of the dropping pill machine whose tank temperature is kept at 85-90°C. Drop the drug solution into liquid paraffin at 7-8°C, take out the dropping pills, remove the oil, select the pills through a sieve, and make 1000 dropping pills.

Claims (12)

1. treat the treating coronary heart disease and angina pectoris drop pill for one kind, it is that crude drug is made with Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Codonopsis and Borneolum Syntheticum perhaps with Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Ginseng and Borneolum Syntheticum, it is characterized in that the processing step of its preparation is:

(1) Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Ginseng or Radix Codonopsis are mixed or make water extract or alcohol extract separately;

(2) described extracting solution being carried out predefecation handles;

(3) further described extracting solution is carried out hyperfiltration treatment;

(4) ultrafiltrate is concentrated, with gained extractum and Borneolum Syntheticum and adjuvant mixed even after, make drop pill;

The operating procedure condition of described hyperfiltration treatment is as follows:

The inlet pressure of ultrafiltration is 0.1～0.5MPa, and the liquid outlet pressure ratio inlet pressure of ultrafiltration hangs down 0.25～0.5kPa; Feed temperature is 15～50 ℃; The pH value of feed liquid is controlled at 5～9; When feed liquid stock solution is concentrated 1/15～1/5, add water or dilute alcohol solution ultrafiltration 1～2 time again;

The weight proportion of described crude drug is: Radix Salviae Miltiorrhizae 20～97, Radix Notoginseng 2～79, Borneolum Syntheticum 0.2～3, Radix Ginseng or Radix Codonopsis 10～40.

2. medicinal dropping ball according to claim 1 is characterized in that the weight proportion of described crude drug is:

Radix Salviae Miltiorrhizae 63.0～94.0,

Radix Notoginseng 4.0～35.0,

Borneolum Syntheticum 0.5～2.0,

Radix Ginseng or Radix Codonopsis 15～30.

3. medicinal dropping ball according to claim 2 is characterized in that the weight proportion of described crude drug is:

Radix Salviae Miltiorrhizae 75.2～90,

Radix Notoginseng 9～23.5,

Borneolum Syntheticum 0.5～1.3,

Radix Ginseng or Radix Codonopsis 20～25.

4. medicinal dropping ball according to claim 1 is characterized in that described alcohol extract is to be selected from the following lower alcohol or the extracting solution of its mixture: methanol, ethanol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutanol.

5. medicinal dropping ball according to claim 4, its feature is an ethanol extract at described alcohol extract.

6. what medicinal dropping ball according to claim 1, its feature obtained in described step (1) is the ethanol extract that Radix Salviae Miltiorrhizae, Radix Notoginseng and Radix Ginseng or Radix Codonopsis are mixed and made into.

7. what medicinal dropping ball according to claim 1, its feature obtained in described step (1) is the aqueous extract that Radix Salviae Miltiorrhizae, Radix Notoginseng and Radix Ginseng or Radix Codonopsis are mixed and made into.

8. medicinal dropping ball according to claim 1, its feature in described step (1) is: the Radix Salviae Miltiorrhizae of the coarse pulverization of learning from else's experience, Radix Notoginseng and Radix Ginseng or codonopsis pilosula add an amount of sodium bicarbonate to extraction pot, decoct with water secondary, filter, filtering residue discards, merging filtrate gets extracting solution.

9. medicinal dropping ball according to claim 1 is characterized in that described predefecation is treated to coarse filtration-adsorption clarification, adsorption clarification-high speed centrifugation, coarse filtration-microfiltration or coarse filtration-precipitate with ethanol.

10. medicinal dropping ball according to claim 1, it is characterized in that the used ultrafilter membrane of described hyperfiltration treatment is selected from: cellulose diacetate film, three cellulose acetate membrane, cyanoethyl cellulose film, polysulfone membrane, sulfonated polysulfone membrane, poly (ether sulfone) film, sulfonated polyether sulfone film, polysulfonamides film, phenolphthalein side group polyarylsulfone (PAS) film, polyvinylidene fluoride film, polyacrylonitrile film, polyimide film, cellulose membrane, methyl methacrylate-acrylonitrile copolymer film, polyacrylonitrile/cellulose diacetate blend film, the dynamically ultrafilter membrane that forms, and the Modified Membrane of above-mentioned film; The molecular cut off of its ultrafilter membrane is 6000～80000.

11. medicinal dropping ball according to claim 10, it is characterized in that described ultrafilter membrane is selected from: cellulose diacetate film, three cellulose acetate membrane, polysulfone membrane, sulfonated polysulfone membrane, poly (ether sulfone) film, sulfonated polyether sulfone film, polysulfonamides film, polyvinylidene fluoride film, polyacrylonitrile film; The molecular cut off of its ultrafilter membrane is 10000～70000.

12. medicinal dropping ball according to claim 1 is characterized in that, in the process of described ultrafiltration separately or unite the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation, feed noble gas off and on; Wherein the pressure wave moment of periodic pressure fluctuation is 0.1～0.2Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～2.0 meter per seconds, feeds noble gas off and on and be ventilation in 0.5 hour～2 hours once, each 1 minute.