CN1778338B - Chinese medicine composition for treating coronary heart disease and angina cordis - Google Patents

Abstract

A Chinese medicine for treating coronary heart disease and angina pectoris is prepared from red sage root, notoginseng, borneol and ginseng or pilose asiabell root through extracting the liquid extract from red sage root, notoginseng, borneol, and ginseng or pilose asiabell root in water or alcohol, clarifying, ultrafiltering, concentrating, adding borneol and shaping.

Description

Traditional Chinese medicine composition for treating coronary heart disease angina pectoris

technical field

The invention relates to a traditional Chinese medicine composition prepared by an ultrafiltration process. Specifically, the invention relates to a traditional Chinese medicine composition for treating angina pectoris of coronary heart disease prepared by ultrafiltration.

Background technique

Compound Danshen Tablet is a variety recorded in the Chinese Pharmacopoeia. It has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is commonly used clinically for chest tightness and angina pectoris. The traditional process is: take Salvia miltiorrhiza and extract 3 times, add ethanol to reflux for 1.5 hours for the first time, filter, recover ethanol from the filtrate, concentrate to a relative density of 1.30 (55-60°C); add 50% ethanol for the second time and reflux for 1.5 hours , filtered. For the third time, add water and reflux for 2 hours, filter, combine the second and third filtrates, recover ethanol, concentrate to a relative density of 1.40 (55-60°C), combine with the first concentrated solution, and mix well to prepare It forms an extract with a relative density of 1.35 to 1.39 (55°C). Crush Panax notoginseng into fine powder, mix with salvia miltiorrhiza extract, dry and make granules. Grind the borneol finely, mix it with the above granules, press it into 1000 pieces, or coat it with sugar.

Although the above-mentioned process can retain most of the active ingredients and remove a considerable amount of impurities, recent studies have found that many polysaccharides and many trace elements related to immunity have great Large loss; and the production cycle of this production process is long, the process is complicated, the production cost is high, the stability of the finished product is poor, and it is easy to produce environmental pollution.

Membrane separation technology (Membrane Separation Technique) is a new high-efficiency separation technology, which has been internationally recognized as the most promising high-tech production technology from the end of the 20th century to the middle of the 21st century. Ultrafiltration (UF) technology is a membrane separation technology whose basic principle is to use the selective screening performance of membrane pores to separate, purify and concentrate substances. The ultrafiltration method uses an anisotropic membrane (that is, an asymmetric membrane) made of polymer materials as the filter medium. Under normal temperature conditions, relying on a certain pressure and flow rate, the solution flows through the membrane surface, forcing low molecular weight substances to permeate. Through the membrane, the polymer substances are intercepted.

Because the ultrafiltration method is a physical method, it has the characteristics of no need for repeated heating, no "phase state" change, less possibility of destroying active ingredients than other general methods, and short process flow, so it is applied to the research of extracting active ingredients of traditional Chinese medicine Increasingly active, some products have moved from laboratory research to industrial production. People's Liberation Army 304 Hospital Wang Shiling and others used ultrafiltration to extract the active ingredient baicalin in Scutellaria baicalensis. The results showed that the ultrafiltration method was superior to the conventional method in terms of yield and purity, and one ultrafiltration can meet the requirements of injections without further steps. Refined, simple process, the production cycle can be shortened by 1 to 2 times (Wang Shiling, Zheng Dianbao "A Preliminary Investigation on the Extraction of Baicalin by Ultrafiltration", Chinese Patent Medicine Research, 1988 (3): 5). Wang Shiling and others have further studied the optimal process conditions for extracting baicalin by ultrafiltration. The experimental results prove that the selection of an ultrafiltration membrane with a suitable pore size (molecular weight cut-off is 6000-10000) is the key to improving the yield and quality of baicalin. Liquid temperature or lower concentration, strictly control the pH value (pH=1.5 during acidification, pH=7.0 during alkali dissolution), can significantly improve the ultrafiltration speed, and obtain the best output effect (Wang Shiling, "One-time extraction of baicalin by ultrafiltration Technology Research", Chinese Patent Medicine, 1994, 16(3): 2). Xu Jinlin and others used the ultrafiltration method (polysulfone membrane, molecular weight cut-off 6000) in the preparation of phytic acid, and the yield of phytic acid was 86.4%, which was 12.6% higher than the conventional phytate method, and the phytic acid obtained by the ultrafiltration method was almost It does not contain inorganic phosphorus, and its appearance is transparent and almost colorless (Xu Jinlin, Xu Jie, Wang Yuanjin "Research on Preparation of Phytic Acid by Membrane Separation Technology", China Journal of Pharmaceutical Industry, 1994, 25(4): 150). He Changsheng and others applied ultrafiltration technology to separate and refine stevioside, and used ultra-thin plate ultrafilter and cellulose acetate membrane (CA membrane) with a molecular weight cut-off of 10,000 to carry out field experiments on the purification of stevioside. The process flow is reasonable and feasible. The performance of the ultrafilter is stable, the decolorization performance of the membrane and the effect of removing impurities are good, which can better solve the problems of precipitation and foaming during potting that often occur in the production of stevioside (He Changsheng, Wang Bingnan, Zhu Shanshan "Stevioside Application Research of Ultrafiltration", Water Treatment Technology, 1994, 20(2): 89). Huang Ziqiang used ultrafiltration membranes (polysulfone membranes with a molecular weight cut-off of 4000 and 10000) to refine camellia oleifera saponin, compared with the bleaching method, recrystallization method, alcohol ether precipitation method and alkaline salt precipitation method mostly used in China, the ultrafiltration process flow Simple, efficient, low cost, to remove grease, pigments, sugars and other highly hydrophilic impurities in the crude camellia saponin, all can achieve the expected effect (Huang Ziqiang, "Ultrafiltration membrane method refining camellia saponin preliminary research" water Process Technology, 1995, 21(2):99). Guo Liwei from Nanjing University of Traditional Chinese Medicine compared and studied the effects of water-alcohol method and ultrafiltration method on the clarification of Cornus officinalis preparations on the ingredients contained in the preparations. Ultrafiltration membrane has no obvious effect on loganin (molecular weight is 384), but the film with molecular weight cut-off is 1000 makes loganin loss about 50% (Guo Liwei, Peng Guoping, Pan Yang et al. A Comparative Study of Chinese Medicine Preparations from Cornus officinalis", Chinese Patent Medicine, 1999, 21(2): 59). Wang Chengzhang et al. used ultrafiltration (polysulfone membrane, molecular weight cut-off 30000) and polyamide resin adsorption elution method to separate and purify the ethanol extract of Ginkgo biloba leaves, and the content of ginkgo flavonoid glycosides was detected by high performance liquid chromatography (HPLC). At about 45%, the yield is 0.5% to 0.7%, which is superior to conventional steam distillation and organic solvent extraction, and can reduce waste water discharge in the ultrafiltration process, protect the environment, reduce production costs, and improve economic benefits ( Wang Chengzhang, Yu Qing, Tan Weihong, etc. "Application of Ultrafiltration in the Purification of Ginkgo Flavonoid Glycosides", Forestry Science and Technology Communication, 1997, (2): 21).

Although the application of ultrafiltration technology in the production of traditional Chinese medicine preparations has its unique advantages, the extent of its application is still very limited. The reason is that there are still the following problems:

(1) The composition of Chinese herbal medicine is complex, especially in many compound preparations, the active ingredients have not been fully understood, so it needs to be thoroughly studied before applying ultrafiltration technology to Chinese herbal medicine preparations. For example, due to the complexity of the components, it is impossible to apply ultrafiltration to the production of most traditional Chinese medicine preparations before a large number of pharmacological and clinical research tests are conducted to fully evaluate the effect of ultrafiltration on the efficacy of each component in traditional Chinese medicine preparations.

(2) There are few types of membrane materials, the membrane pore size distribution is wide, and the performance is not stable. The ultrafiltration membrane materials used in the production of traditional Chinese medicine preparations include cellulose acetate, polyacrylonitrile, polysulfone, sulfonated polysulfone, polysulfone amide, etc. According to its affinity to water, it can be roughly divided into two categories: hydrophobic membrane materials and hydrophilic membrane materials. Hydrophilic membrane materials such as cellulose acetate and sulfonated polysulfone have less adsorption of solutes and a smaller molecular weight cut-off, but poor thermal stability, mechanical strength, chemical resistance, and bacterial erosion resistance are usually not high; polysulfone and other hydrophobic Membrane material has high mechanical strength, high temperature resistance, solvent resistance, and biodegradation resistance, but because the molecular chain contains a large number of hydrophobic genes or chain links, and has a lot of electrostatic charges, the membrane has a low water permeability and low anti-pollution ability .

(3) Membrane fouling is the biggest obstacle preventing ultrafiltration technology from laboratory research to industrial application. In the ultrafiltration process of traditional Chinese medicine preparations, if the pretreatment effect of the liquid medicine is not good, the membrane surface will be easily polluted and the membrane pores will be blocked, which will reduce the permeation flux, that is, the productivity, or even fail to work normally, reduce the production efficiency, and increase the cost, resulting in membrane shortened service life.

(4) The selection method of membrane modules has not been established yet, and the operating parameters of ultrafiltration still need to be optimized. There are many factors that affect the effect of ultrafiltration, including the selection of membrane components, the determination of process parameters and the cleaning method of the ultrafilter after use. Therefore, the ultrafiltration equipment and operating technology suitable for ultrafiltration of traditional Chinese medicine systems need further research.

Regarding the practical application of compound Danshen tablets prepared by ultrafiltration, there are no reports in the current literature. In particular, the use of ultrafiltration for industrial production has always been a technical problem in this field.

Through long-term and unremitting efforts, the inventor has verified the feasibility of preparing the medicine of the present invention by the ultrafiltration method by analyzing a large amount of experimental data, and determined suitable process operating conditions, in order to utilize the ultrafiltration method to carry out the industrialized production of the medicine of the present invention Specific solutions are provided.

Contents of the invention

The object of the invention is to provide a traditional Chinese medicine composition for treating angina pectoris of coronary heart disease.

The present invention is realized through the following technical steps: using salvia miltiorrhiza, notoginseng, borneol and ginseng as raw materials, it is prepared according to the following steps:

(1) Mix salvia miltiorrhiza, Panax notoginseng, and ginseng to make water extract or alcohol extract;

(2) Carry out preliminary clarification treatment to described extract;

(3) further carry out ultrafiltration treatment to described extract;

(4) Concentrate the ultrafiltrate, add borneol, and make a preparation according to a conventional method.

The ratio of the above-mentioned raw materials is calculated by weight: 20-97 parts of Danshen, 2-79 parts of Panax notoginseng, 0.2-3 parts of Borneolum, 10-40 parts of Radix Ginseng; 2.0, ginseng 15-30; more preferably: salvia miltiorrhiza 75.2-90, Sanqi 9-23.5, borneol 0.5-1.3, ginseng 20-25.

The above-mentioned raw material ginseng can be replaced by Codonopsis ginseng, that is, the above-mentioned raw material drug can be Danshen 20-97, Sanqi 2-79, Borneol 0.2-3, Codonopsis 10-40; preferably: Danshen 63.0-94.0, Sanqi 4.0-35.0, Borneol 0.5-2.0, Codonopsis 15-30; more preferably: Danshen 75.2-90, Panax notoginseng 9-23.5, Borneol 0.5-1.3, Codonopsis 20-25.

In the technical step (1) of the present invention, the alcohol extract can be lower alcohols of different concentrations such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, etc., or extracts of their mixtures. The alcohol extract can be subjected to the next preliminary clarification treatment without concentration or after proper concentration.

In the technical step (2) of the present invention, preliminary clarification treatment can carry out rough filtration with general material such as gauze, silk silk etc., also can carry out microfiltration with more professional material such as ceramic membrane, also can get supernatant after high-speed centrifugation Liquid, also can use flocculant such as chitosan flocculation clarifier, 101 fruit juice clarifier, ZTC1+1 natural clarifier, egg white flocculant etc. Some impurities. The above clarification methods can be used alone or in combination, such as coarse filtration-adsorption clarification, adsorption clarification-high-speed centrifugation, coarse filtration-microfiltration, coarse filtration-alcohol precipitation, etc. The solution that has been preliminarily clarified can be subjected to the next step of ultrafiltration without concentration or after being properly concentrated; preferably, the next step of ultrafiltration is performed without concentration.

In the technical step (3) of the present invention, the ultrafiltration membrane used for ultrafiltration can be cellulose diacetate membrane (CA), cellulose triacetate membrane (CTA), cyanoethyl cellulose acetate membrane (CN-CA), polyester Sulfone membrane (PS), sulfonated polysulfone membrane (SPS), polyethersulfone membrane (PFS), sulfonated polyethersulfone membrane (SPES), polysulfone amide membrane (PSA), phenolphthalein side group polyarylsulfone membrane (PDS) ), polyvinylidene fluoride film (PVDF), polyacrylonitrile film (PAN), polyimide film (N), cellulose film, methyl methacrylate-acrylonitrile copolymer film (MMA-AN), poly Acrylonitrile/cellulose diacetate (PAN/CA) blend membranes, dynamically formed ultrafiltration membranes, and modified membranes of the above membranes. Preferably cellulose diacetate membrane (CA), cellulose triacetate membrane (CTA), polysulfone membrane (PS), sulfonated polysulfone membrane (SPS), polyethersulfone membrane (PES), sulfonated polyethersulfone membrane (SPES), polysulfoneamide membrane (PSA), polyvinylidene fluoride membrane (PVDF), polyacrylonitrile membrane (PAN).

The molecular weight cut-off of the ultrafiltration membrane is generally 6000-80000, preferably 10000-70000, most preferably 20000-50000.

Ultrafiltration can be either cross-flow filtration or dead-end filtration, but cross-flow filtration is preferred.

The operating conditions of the ultrafiltration process are as follows:

(1) The inlet pressure of the ultrafiltration is 0.1-0.5MPa, preferably 0.1-0.35Mpa, and most preferably 0.25-0.35Mpa; the outlet pressure of the ultrafiltration is 0.5-0.25kPa lower than the inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.1-0.2Mpa.

(2) The flow rate of the feed liquid is 1.0-4.0 m/s, preferably 2.0-3.0 m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unsteady flow in the membrane channel, and the flow velocity fluctuation difference is 1.0-2.0m/s.

(3) In the ultrafiltration system, high-pressure inert gas such as nitrogen is fed intermittently to form a gas-liquid pulse flow, and the cycle is 0.5h-2h to ventilate once, each time for 1 minute.

(3) The feed liquid temperature is 15-50°C, preferably 20-40°C.

(4) When the stock solution is concentrated by 1/15 to 1/5, add water or dilute alcohol solution for ultrafiltration 1 to 2 times; preferably when the stock solution is concentrated by 1/12 to 1/8, add water Or dilute alcohol solution ultrafiltration 1 to 2 times.

(5) The pH value of the feed liquid is controlled at 5 to 9, preferably 6.0 to 7.5;

(6) Backwashing conditions: Backwashing pressure is 0.15-2.5MPa, backwashing cycle is 0.5-1.5h, and backwashing time is 1min-10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time To carry out, generally work for 10 to 20 minutes, and recoil for 30 seconds to 3 minutes.

(7) The chemical cleaning period is 0.5 months to February. The chemical cleaning agents are generally dilute acids, dilute alkalis, and surfactants, preferably dilute alkalis, such as 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2 % sodium hypochlorite mixed solution, etc., the pH value is 10-12, and the cleaning working pressure is 0.05-1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

In the ultrafiltration process, periodic pressure fluctuations or periodic flow fluctuations or periodic inert gas injections can be used alone, or in combination, that is, periodic pressure fluctuations and periodic flow fluctuations are used in combination, or periodic pressure fluctuations It is used in combination with periodic inert gas injection, or in combination with periodic flow fluctuations and inert gas injection, or in combination with the three.

In the technical step (4) of the present invention, after the ultrafiltrate is concentrated into an extract, the preparation is then prepared in a conventional manner. For example, it can be mixed with any one or more pharmaceutical excipients such as starch, dextrin, lactose, microcrystalline cellulose, hydroxypropylmethylcellulose, polyethylene glycol, magnesium stearate, micronized silica gel, xylose Alcohol, lactitol, glucose, glycine, mannitol, glycine, etc. are mixed to form tablets, capsules, granules, oral liquids, sustained-release preparations, controlled-release preparations, gels, ointments, ointments, creams, suppositories , injections, powder injections, patches, dripping pills, suspensions, etc.

Experimental Example Clinical Observation on Drug Treatment of Coronary Heart Disease Angina Pectoris by the Present Invention

1 clinical data

1.1 General information The observation group consisted of 38 cases, including 21 males and 17 females. The age ranged from 38 to 80 years old, with an average of 53.5 years old. Among them, there were 24 cases of angina pectoris, 8 cases of old myocardial infarction, and 6 cases of arrhythmia. The control group consisted of 30 cases, including 17 males and 13 females. The age ranged from 43 to 85 years old, with an average of 51.5 years old. Among them, there were 21 cases of angina pectoris, 5 cases of old myocardial infarction, and 4 cases of arrhythmia. The above two groups were all in line with the diagnostic criteria of the "Recommendations for Coronary Heart Disease Nomenclature and Diagnostic Criteria" presented by the National Internal Medicine Academic Conference in 1980.

1.2 Treatment method observation group: take medicine (tablet) of the present invention, 3 tablets/time, 3 times/day. At the same time, take 10 mg/time of Xiaoxin Pain, 3 times/day, and 75 mg/time of aspirin, 1 time/day. Control group: taking Xiaoxinpu 10mg times, 3 times/day, and oral aspirin 75mg/time, 1 time/d. The two groups were observed for 4 weeks (1 course of treatment), and other coronary expansion drugs were stopped during the observation period.

2 results

2.1 Efficacy Judgment Criteria Evaluate according to the angina pectoris and electrocardiogram curative effect evaluation standards for coronary heart disease formulated by the Shanghai Conference in 1979. Significantly effective: symptoms disappear, electrocardiogram in resting state returns to normal or positive in exercise test turns negative, and premature beats disappear; effective: clinical symptoms are relieved, S-T segment of electrocardiogram at rest rises by 0.03-0.05mv, and premature beats are reduced compared with before treatment; invalid: Clinical symptoms, no changes in ECG, no reduction in premature beats.

2.2 Treatment results Among the 38 cases in the observation group, 20 cases were markedly effective, accounting for 52.6%. 14 cases were effective, accounting for 36.8%; 4 cases were ineffective, accounting for 10.5%; the total effective rate was 89.5%. Among the 30 cases in the control group, 11 cases were markedly effective, accounting for 36.7%; 10 cases were effective, accounting for 33.3%; 9 cases were ineffective, accounting for 30%; the total effective rate was 70%. The curative effect of the observation group was significantly better than that of the control group (P<0.05).

Detailed ways

The present invention will be further elaborated below in conjunction with embodiment. These examples are for illustrative purposes only and do not limit the invention in any way.

Embodiment one

The raw materials are 375g of Danshen, 118g of Radix Notoginseng, 8g of Borneolum, and 100g of Radix Ginseng.

Extracting the salvia miltiorrhiza and ginseng with ethanol to obtain an ethanol extract of the salvia miltiorrhiza and ginseng, filtering the extract with gauze, and collecting the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30sec. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Crush notoginseng into fine powder, mix with the above extract, dry and make granules. Grind the borneol finely, mix it with the above granules, press it into 1000 pieces, or coat it with sugar.

Embodiment two

The raw materials are 465g of Danshen, 30g of Panax notoginseng, 8g of borneol, and 85g of ginseng.

The ethanol extracts of the salvia miltiorrhiza and the ginseng are obtained by extracting the salvia miltiorrhiza and the ginseng with ethanol, microfiltration is performed with a ceramic membrane, and the filtrate is collected. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the raw liquid of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain the salvia miltiorrhiza extract with a relative density of 1.35-1.39 (55° C.). Crush Panax notoginseng into fine powder, mix with the above extract, grind borneol finely, mix with the above granules, add 3% povidone ethanol solution to make a soft material, pass through a 18-mesh sieve to make granules, and dry at 60°C for 30~ After 45 minutes, whole grains, add talcum powder, mix well, fill in capsules, and get ready.

Embodiment three

260g of salvia miltiorrhiza, 165g of notoginseng, 7g of borneol, and 170g of ginseng were used as raw materials.

Extracting Danshen, Panax notoginseng and Panax ginseng with ethanol to obtain a mixed ethanol extract, centrifuging the extract at high speed and then separating the supernatant. The liquid is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1/8, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Dry and make granules. Grind borneol finely, mix with the above granules, add appropriate amount of magnesium stearate, mix evenly, press into 1000 pieces, or coat with sugar, to obtain.

Embodiment four

The raw material medicine adopts 490 grams of salvia miltiorrhiza, 84 grams of notoginseng, 6 grams of borneol, and 60 grams of ginseng.

Add coarsely crushed salvia miltiorrhiza, notoginseng and ginseng to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30sec. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32-1.40 (55°C), add borneol, mix evenly, fluidize with lactose in a batch fluidized bed, dry, and make granules.

Embodiment five

The raw material medicine adopts 242 grams of salvia miltiorrhiza, 255 grams of notoginseng, 4 grams of borneol, and 100 grams of ginseng.

Add coarsely crushed salvia miltiorrhiza, notoginseng and ginseng to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the raw liquid of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32-1.40 (55° C.), add borneol, add 30 g of mannitol, 5 g of calcium sodium edetate, and 5 ml of distilled water. After mixing the above components, freeze Dry, sub-package, that is.

Embodiment six

162 grams of salvia miltiorrhiza, 295 grams of notoginseng, 4 grams of borneol, and 138 grams of ginseng were used as raw materials.

Add coarsely crushed salvia miltiorrhiza, notoginseng and ginseng to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1/8, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.32-1.40 (55° C.), mixing the extract with borneol and an appropriate amount of magnesium stearate, and pressing it into tablets.

Embodiment seven

The raw materials are 375g of Danshen, 118g of Radix Notoginseng, 8g of Borneolum, and 100g of Codonopsis pilosula.

Extracting Danshen and Codonopsis with ethanol to obtain ethanol extracts of Danshen and Codonopsis, filtering the extract with gauze, and collecting the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30sec. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Crush notoginseng into fine powder, mix with the above extract, dry and make granules. Grind the borneol finely, mix it with the above granules, press it into 1000 pieces, or coat it with sugar.

Embodiment Eight

The raw materials are 465g of Danshen, 30g of Panax notoginseng, 8g of borneol, and 85g of Codonopsis pilosula.

Extracting Danshen and Codonopsis with ethanol to obtain ethanol extracts of Danshen and Codonopsis, performing microfiltration with a ceramic membrane, and collecting the filtrate. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the raw liquid of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain the salvia miltiorrhiza extract with a relative density of 1.35-1.39 (55° C.). Crush Panax notoginseng into fine powder, mix with the above extract, grind borneol finely, mix with the above granules, add 3% povidone ethanol solution to make a soft material, pass through a 18-mesh sieve to make granules, and dry at 60°C for 30~ After 45 minutes, whole grains, add talcum powder, mix well, fill in capsules, and get ready.

Embodiment nine

The raw materials are 260g of Salvia miltiorrhiza, 165g of Sanqi, 7g of borneol, and 170g of Codonopsis pilosula.

Extract Danshen, Panax notoginseng and Codonopsis pilosula with ethanol to obtain a mixed ethanol extract, centrifuge the extract at high speed and separate the supernatant. The liquid is ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1/8, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.35-1.39 (55° C.). Dry and make granules. Grind borneol finely, mix with the above granules, add appropriate amount of magnesium stearate, mix evenly, press into 1000 pieces, or coat with sugar, to obtain.

Embodiment ten

The raw material medicine adopts 490 grams of salvia miltiorrhiza, 84 grams of notoginseng, 6 grams of borneol, and 60 grams of Codonopsis pilosula.

Add coarsely crushed Danshen, Panax notoginseng and Codonopsis pilosula to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the feed liquid is 1.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 1.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 0.5h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 15°C. When the original feed liquid is concentrated by 1/15, add water or dilute alcohol solution for ultrafiltration once, and the pH value of the feed liquid is controlled at 5. The backwash pressure is 0.15MPa, the backwash cycle is 0.5h, and the backwash time is 1min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 10min, recoil for 30see. The chemical cleaning cycle is 0.5 months, the chemical cleaning agent is a mixed solution of 0.5%-4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10-12, and the cleaning working pressure is 0.05MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32-1.40 (55°C), add borneol, mix evenly, fluidize with lactose in a batch fluidized bed, dry, and make granules.

Embodiment Eleven

242 grams of salvia miltiorrhiza, 255 grams of notoginseng, 4 grams of borneol, and 100 grams of Codonopsis pilosula are used as raw materials.

Add coarsely crushed Danshen, Panax notoginseng and Codonopsis pilosula to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 4.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 50°C. When the raw liquid of the feed liquid is concentrated by 1/5, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 9. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrate the ultrafiltrate to obtain an extract with a relative density of 1.32-1.40 (55° C.), add borneol, add 30 g of mannitol, 5 g of calcium sodium edetate, and 5 ml of distilled water. After mixing the above components, freeze Dry, sub-package, that is.

Embodiment 12

The raw materials are 162 grams of Danshen, 295 grams of Radix Notoginseng, 4 grams of Borneolum, and 138 grams of Codonopsis pilosula.

Add coarsely crushed Danshen, Panax notoginseng and Codonopsis pilosula to the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter , discard the filter residue, and combine the filtrates. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m/s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m/s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1/8, add water or dilute alcohol solution for ultrafiltration twice, and the pH value of the feed liquid is controlled at 7.5. The backwash pressure is 2.5MPa, the backwash cycle is 1.5h, and the backwash time is 10min. When the ultrafiltration modules are connected in parallel to use the method of alternate backflushing, one or several sets perform normal ultrafiltration and part of the filtrate is flowed out to backwash the ultrafiltration membrane of another set or several sets of components, and exchange after a period of time Carry out, work for 20 minutes, recoil for 3 minutes. The chemical cleaning cycle is 2 months, the chemical cleaning agent is a mixed solution of 0.5% to 4.0% sodium hydroxide, 1.5% sodium hydroxide and 2% sodium hypochlorite, the pH value is 10 to 12, and the cleaning working pressure is 1.0MPa. After cleaning with chemical cleaners, rinse with water until nearly neutral.

Concentrating the ultrafiltrate to obtain an extract with a relative density of 1.32-1.40 (55° C.), mixing the extract with borneol and an appropriate amount of magnesium stearate, and pressing it into tablets.

Claims (11)

1. a Chinese medicine composition for the treatment of angina pectoris is characterized in that, it is to be prepared from by following raw materials in weight portion: Radix Salviae Miltiorrhizae 20～97, Radix Notoginseng 2～79, Borneolum Syntheticum 0.2～3, Radix Ginseng or Radix Codonopsis 10～40;

Described preparation method is:

(a) Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Ginseng or Radix Codonopsis are mixed or make water extract or alcohol extract separately;

(b) described extracting solution being carried out predefecation handles;

(c) further described extracting solution is carried out hyperfiltration treatment;

(d) ultrafiltrate is concentrated, add Borneolum Syntheticum, make preparation according to a conventional method;

The operating procedure condition of described hyperfiltration treatment is as follows:

The inlet pressure of ultrafiltration is 0.1～0.5MPa, and the liquid outlet pressure ratio inlet pressure of ultrafiltration hangs down 0.25～0.5kPa; Feed temperature is 15～50 ℃; The pH value of feed liquid is controlled at 5～9; When feed liquid stock solution is concentrated 1/15～1/5, add water or dilute alcohol solution ultrafiltration 1～2 time again;

In the process of described ultrafiltration separately or unite the following method that adopts: periodic pressure fluctuation, periodically flow fluctuation, feed noble gas off and on; Wherein the pressure wave moment of periodic pressure fluctuation is 0.1～0.2Mpa, and periodically the flow speed wave moment of flow fluctuation is 1.0～2.0 meter per seconds, feeds noble gas off and on and be ventilation in 0.5 hour～2 hours once, each 1 minute.

2. Chinese medicine composition as claimed in claim 1 is characterized in that, the weight portion proportioning of described raw material is:

Radix Salviae Miltiorrhizae 63.0～94.0,

Radix Notoginseng 4.0～35.0,

Borneolum Syntheticum 0.5～2.0,

Radix Ginseng or Radix Codonopsis 15～30.

3. Chinese medicine composition as claimed in claim 2 is characterized in that, the weight portion proportioning of described raw material is:

Radix Salviae Miltiorrhizae 75.2～90,

Radix Notoginseng 9～23.5,

Borneolum Syntheticum 0.5～1.3,

Radix Ginseng or Radix Codonopsis 20～25.

4. Chinese medicine composition as claimed in claim 1 is characterized in that, described alcohol extract is to be selected from the following lower alcohol or the extracting solution of its mixture: methanol, ethanol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutanol.

5. Chinese medicine composition as claimed in claim 1 is characterized in that, described alcohol extract is an ethanol extract.

6. Chinese medicine composition as claimed in claim 1 is characterized in that, what described step (a) obtained is the ethanol extract of Radix Salviae Miltiorrhizae and Radix Ginseng or Radix Salviae Miltiorrhizae and Radix Codonopsis.

7. Chinese medicine composition as claimed in claim 1 is characterized in that, what described step (a) obtained is the aqueous extract that Radix Salviae Miltiorrhizae, Radix Notoginseng and Radix Ginseng or Radix Salviae Miltiorrhizae, Radix Notoginseng and Radix Codonopsis are mixed and made into.

8. Chinese medicine composition as claimed in claim 1 is characterized in that described predefecation is treated to coarse filtration-adsorption clarification, adsorption clarification-high speed centrifugation, coarse filtration-microfiltration or coarse filtration-precipitate with ethanol.

9. Chinese medicine composition as claimed in claim 1, it is characterized in that, the used ultrafilter membrane of described hyperfiltration treatment is selected from: cellulose diacetate film, three cellulose acetate membrane, cyanoethyl cellulose film, polysulfone membrane, sulfonated polysulfone membrane, poly (ether sulfone) film, sulfonated polyether sulfone film, polysulfonamides film, phenolphthalein side group polyarylsulfone (PAS) film, polyvinylidene fluoride film, polyacrylonitrile film, polyimide film, cellulose membrane, methyl methacrylate-acrylonitrile copolymer film, polyacrylonitrile/cellulose diacetate blend film, the dynamically ultrafilter membrane that forms, and the Modified Membrane of above-mentioned film; The molecular cut off of its ultrafilter membrane is 6000～80000.

10. Chinese medicine composition as claimed in claim 9, it is characterized in that, described ultrafilter membrane is selected from: cellulose diacetate film, three cellulose acetate membrane, polysulfone membrane, sulfonated polysulfone membrane, poly (ether sulfone) film, sulfonated polyether sulfone film, polysulfonamides film, polyvinylidene fluoride film, polyacrylonitrile film; The molecular cut off of its ultrafilter membrane is 10000～70000.

11. Chinese medicine composition as claimed in claim 1, it is characterized in that described preparation contains any or more than one are selected from following pharmaceutics adjuvant: starch, dextrin, lactose, microcrystalline Cellulose, hydroxypropyl methylcellulose, Polyethylene Glycol, magnesium stearate, micropowder silica gel, xylitol, lactose, glucose, glycine, mannitol.