CN1259944A - 选择性的雌激素受体调节剂用于治疗或预防前列腺癌及良性前列腺增生 - Google Patents
选择性的雌激素受体调节剂用于治疗或预防前列腺癌及良性前列腺增生 Download PDFInfo
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- CN1259944A CN1259944A CN98805956A CN98805956A CN1259944A CN 1259944 A CN1259944 A CN 1259944A CN 98805956 A CN98805956 A CN 98805956A CN 98805956 A CN98805956 A CN 98805956A CN 1259944 A CN1259944 A CN 1259944A
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- hydroxyl
- benzo
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- thiophene
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 229950004288 tosilate Drugs 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4322397P | 1997-04-09 | 1997-04-09 | |
| US60/043,223 | 1997-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1259944A true CN1259944A (zh) | 2000-07-12 |
Family
ID=21926126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98805956A Pending CN1259944A (zh) | 1997-04-09 | 1998-04-07 | 选择性的雌激素受体调节剂用于治疗或预防前列腺癌及良性前列腺增生 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0975629A4 (no) |
| JP (1) | JP2001518900A (no) |
| KR (1) | KR20010006218A (no) |
| CN (1) | CN1259944A (no) |
| AU (1) | AU6966198A (no) |
| BR (1) | BR9808515A (no) |
| CA (1) | CA2286204A1 (no) |
| EA (1) | EA199900914A1 (no) |
| HU (1) | HUP0003589A3 (no) |
| ID (1) | ID24358A (no) |
| IL (1) | IL132277A0 (no) |
| NO (1) | NO994903L (no) |
| PL (1) | PL336205A1 (no) |
| TR (1) | TR199902701T2 (no) |
| WO (1) | WO1998045288A1 (no) |
| ZA (1) | ZA982819B (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6413533B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US6610706B1 (en) | 1999-07-29 | 2003-08-26 | Eli Lilly And Company | Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride |
| US6653479B1 (en) | 1999-07-29 | 2003-11-25 | Eli Lilly And Company | Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride |
| EP1392304A1 (en) * | 2001-05-10 | 2004-03-03 | Cedars Sinai Medical Center | Use of benzothiophenes to treat and prevent prostate cancer |
| US7425565B2 (en) * | 2002-05-09 | 2008-09-16 | Cedars-Sinai Medical Center | Use of benzothiopenes to treat and prevent prostate cancer |
| US7825107B2 (en) * | 2006-05-22 | 2010-11-02 | Hormos Medical Ltd. | Method of treating men suffering from chronic nonbacterial prostatitis with SERM compounds or aromatase inhibitors |
| EA022760B1 (ru) | 2007-10-16 | 2016-02-29 | Репрос Терапьютикс Инк. | Применение транс-кломифена для предотвращения или лечения диабета 2 типа у мужчин |
| AU2013225869B2 (en) | 2012-02-29 | 2017-06-08 | Repros Therapeutics Inc. | Combination therapy for treating androgen deficiency |
| MA38325B1 (fr) | 2013-02-19 | 2019-03-29 | Novartis Ag | Dérivés de benzothiophène et compositions correspondantes en tant qu'agents de dégradation sélectifs des récepteurs des œstrogènes |
| JP7048505B2 (ja) | 2015-11-10 | 2022-04-05 | パラクリン セラピューティクス エービー | Ｐｄｇｆ－ｃｃ阻害剤および抗エストロゲン剤によるｅｒ陰性乳癌の処置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5429922A (en) * | 1988-03-09 | 1995-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for distinguishing virulent and non-virulent toxoplasma infections |
| JP3989569B2 (ja) * | 1995-02-28 | 2007-10-10 | イーライ リリー アンド カンパニー | ベンゾチオフェン化合物、中間体、組成物および方法 |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| US5731342A (en) * | 1996-02-22 | 1998-03-24 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
-
1998
- 1998-04-02 ZA ZA9802819A patent/ZA982819B/xx unknown
- 1998-04-07 EA EA199900914A patent/EA199900914A1/ru unknown
- 1998-04-07 PL PL98336205A patent/PL336205A1/xx unknown
- 1998-04-07 AU AU69661/98A patent/AU6966198A/en not_active Abandoned
- 1998-04-07 HU HU0003589A patent/HUP0003589A3/hu unknown
- 1998-04-07 BR BR9808515-8A patent/BR9808515A/pt not_active Application Discontinuation
- 1998-04-07 ID IDW991188A patent/ID24358A/id unknown
- 1998-04-07 WO PCT/US1998/007274 patent/WO1998045288A1/en not_active Application Discontinuation
- 1998-04-07 IL IL13227798A patent/IL132277A0/xx unknown
- 1998-04-07 CA CA002286204A patent/CA2286204A1/en not_active Abandoned
- 1998-04-07 CN CN98805956A patent/CN1259944A/zh active Pending
- 1998-04-07 EP EP98915488A patent/EP0975629A4/en not_active Withdrawn
- 1998-04-07 TR TR1999/02701T patent/TR199902701T2/xx unknown
- 1998-04-07 JP JP54316898A patent/JP2001518900A/ja active Pending
- 1998-04-07 KR KR1019997009298A patent/KR20010006218A/ko not_active Application Discontinuation
-
1999
- 1999-10-08 NO NO994903A patent/NO994903L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL336205A1 (en) | 2000-06-05 |
| AU6966198A (en) | 1998-10-30 |
| ID24358A (id) | 2000-07-13 |
| HUP0003589A3 (en) | 2002-02-28 |
| EP0975629A4 (en) | 2001-03-21 |
| NO994903L (no) | 1999-12-09 |
| JP2001518900A (ja) | 2001-10-16 |
| CA2286204A1 (en) | 1998-10-15 |
| WO1998045288A1 (en) | 1998-10-15 |
| NO994903D0 (no) | 1999-10-08 |
| EP0975629A1 (en) | 2000-02-02 |
| ZA982819B (en) | 1999-10-04 |
| IL132277A0 (en) | 2001-03-19 |
| BR9808515A (pt) | 2001-06-19 |
| KR20010006218A (ko) | 2001-01-26 |
| EA199900914A1 (ru) | 2000-04-24 |
| HUP0003589A2 (hu) | 2002-01-28 |
| TR199902701T2 (xx) | 2000-02-21 |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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