CN1179975A - A kind of pharmaceutical composition for treating osteoporosis - Google Patents

Abstract

The invention relates to a pharmaceutical composition for treating osteoporosis, which comprises ginseng, sheep bone, live eel, prepared rhizome of rehmannia, Szechuan lovage rhizome, Chinese angelica, red paeony root, red-rooted salvia root, elderberry, native copper, crab, oyster shell, rhubarb, roasted monkshood, roasted nux vomica, peach kernel and safflower.

Description

A kind of pharmaceutical composition for treating osteoporosis

The invention is a pharmaceutical composition for treating osteoporosis. The composition is traditional Chinese herbal medicine in my country, which has good efficacy in the treatment and prevention of osteoporosis. The invention also provides The medicament formed belongs to the field of traditional Chinese medicine,

With the improvement of modern living standards, the life expectancy of the population is gradually increasing, and the elderly population is increasing. The resulting degenerative physiological disease-primary osteoporosis has become one of the important diseases of the health of the elderly. Osteoporosis is a kind of senile disease, a common disease, and there is no specific Chinese medicine preparation in China at present. Osteoporosis is characterized by low bone mass and microarchitectural degradation of bone tissue leading to increased bone fragility, which can easily cause lumbar vertebral compression fractures, femoral neck fractures, wrist and radius fractures. These fractures, especially lumbar fractures, often occur without obvious external force, and often manifest as sudden severe back pain. Along with the growth of population life expectancy, the increase of old people's number, the harm of this disease is just more and more serious. Therefore, finding a kind of Chinese medicine for effectively preventing and treating osteoporosis is one of the important topics in the current medical circle.

The purpose of the present invention is to develop a pharmaceutical composition for treating osteoporosis.

According to the theory of "kidney governs bones" in traditional Chinese medicine, kidney deficiency is the root of the disease in patients with osteoporosis. Curing must seek at the root, and kidney deficiency can be divided into kidney-yin deficiency and kidney-yin deficiency. Using the principle of TCM dialectical treatment, in accordance with the national diagnostic criteria for kidney yin deficiency and kidney yang deficiency, for those with kidney yang deficiency in this disease, tonify kidney yang, replenish essence and nourish blood, strengthen bones and relax tendons, promote blood circulation, remove blood stasis and relieve pain. The inventor has developed a medicine for treating osteoporosis partial kidney yang deficiency through a large number of case studies in clinical practice.

The composition of the pharmaceutical composition of the present invention is in parts by weight:

Ginseng 20-80 parts

Lamb bone 20-80 parts

Rehmannia 20-80 parts

Live eel 80-120 servings

Angelica 30-80 servings

Paeoniae Rubra 30-80 parts

Danshen 30-80 parts

Elderberry 80-120 servings

Natural copper 80-120 parts

Crab 80-120 servings

Rhubarb 30-80 parts

Roasted horse money 30-80 parts

10-40 parts of peach kernel

Safflower 10-40 parts

Chuanxiong 30-80 parts

Zhichuan black 30-80 servings

Oysters 80-120 servings

Its preferred weight ratio of the pharmaceutical composition of the present invention is:

Ginseng 50 servings

Lamb bones 50 parts

Cooked 50 servings

Live eel 100 servings

Angelica 50 servings

Radix Paeoniae Alba 50 parts

Danshen 50 parts

elderberry 100 servings

Natural copper 100 parts

Crab 100 servings

rhubarb 50 parts

Roasted horse money 50 parts

15 servings of peach kernels

15 servings of safflower

Chuanxiong 50 parts

Zhichuan black 50 servings

Oysters 100 servings

The pharmaceutical composition of the present invention can be prepared into any pharmaceutical dosage form suitable for clinical use according to conventional preparation techniques. For example, pills, tablets, capsules, powders, syrups, oral liquids, suspensions, granules, etc.

During the preparation of the above-mentioned pharmaceutical dosage forms of the present invention, conventional pharmaceutical excipients, such as disintegrants, binders, flavoring agents, preservatives, fillers, solubilizers, solubilizers, lubricants, pigments, etc., can be added.

The preparation method of medicine pill of the present invention (trade name is brave bone pill) is:

Ginseng, mutton bone, live eel and crab are quick-freeze-dried and ground into powder. Natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi were ground into fine powder, and the rest of the medicines were made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above-mentioned medicinal powder, and refined into honey to make pills, each weighing 6 grams.

The effects of the medicine of the present invention are: tonifying kidney yang, replenishing essence and blood, strengthening bones and relaxing tendons, promoting blood circulation and removing blood stasis.

Indications: kidney yang deficiency type osteoporosis.

Clinical application: Osteoporosis, cold pain in the waist and spine, poor flexion and extension, unhealed fractures and chills in the limbs, spontaneous sweating, pale complexion, deep and slow pulse, take one pill each time, three times a day, rice wine 100 after meals Milliliter delivery service, 30 days as a course of treatment.

From 1995 to 1997, 30 patients with osteoporosis were treated with the medicine of the present invention. The bone X-ray plain films of 30 patients showed that the bone density of the thoracic spine and hip bones decreased in varying degrees. Among them, there were 6 cases of lumbar compression fracture, 4 cases of femoral neck fracture, 1 case of radial fracture, and 1 case of hip fracture. All 30 patients had medical history of low back pain, knee joint and hip pain in different degrees.

The curative effect evaluation standard of treatment result is:

Significant effect refers to the complete disappearance of pain after medication, and significant improvement in activity function;

It is effective for pain relief and improvement of activity function after medication;

Ineffective means that the pain has not been alleviated after taking the medicine, and other medicines still need to be taken.

According to the above curative effect evaluation criteria, the treatment results are as follows: curative effect Number of cases % female male Number of cases % Number of cases % markedly effective 13 43 10 33.3 3 10 efficient 15 50 10 33.3 5 16.8 invalid 2 7 1 3.3 1 3.3

The total effective rate of the pharmaceutical composition of the present invention in treating osteoporosis is 93%.

Example 1

50 grams of ginseng 50 grams of sheep bone 100 grams of live eel 50 grams of angelica

50 grams of red peony, 50 grams of Chuanxiong, 50 grams of rehmannia, 100 grams of elderberry

Natural Copper 100g Crab 100g Oyster 100g Rhubarb 50g

50 grams of Zhichuan black, 50 grams of roasted horse money, 50 grams of salvia miltiorrhiza, 15 grams of peach kernels

Safflower 15g

Take ginseng, sheep bone, live eel and crab according to the prescription and freeze-dry them quickly to keep biological activity. Grind natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into 100 pills. Pills weigh 6 grams.

Example 2

60 grams of ginseng 30 grams of sheep bone 80 grams of live eel 70 grams of angelica

Radix Paeoniae Rubra 30g Chuanxiong 40g Rehmannia Rehmanniae 40g Elderberry 80g

Natural Copper 90g Crab 90g Oyster 90g Rhubarb 40g

60 grams of Zhichuan black, 50 grams of roasted horse money, 40 grams of salvia miltiorrhiza, 20 grams of peach kernels

Safflower 25g

Take ginseng, sheep bone, live eel and crab according to the prescription and freeze-dry them quickly to keep biological activity. Grind natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into 100 pills. Pills weigh 6 grams.

Example 3

Ginseng 90g Lamb bone 60g Live eel 100g Angelica 40g

50 grams of red peony, 50 grams of Chuanxiong, 80 grams of rehmannia, 120 grams of elderberry

Natural Copper 90g Crab 100g Oyster 100g Rhubarb 30g

40 grams of Zhichuan black, 40 grams of roasted horse money, 80 grams of salvia miltiorrhiza, 30 grams of peach kernels

Safflower 20g

Take ginseng, sheep bone, live eel and crab according to the prescription and freeze-dry them quickly to keep biological activity. Grind natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into 100 pills. Pills weigh 6 grams.

Claims (4)

1, a kind of pharmaceutical composition for the treatment of osteoporosis, it is characterized in that the composition of this composition is by weight: Ginseng 20-80 parts Lamb bone 20-80 parts Rehmannia 20-80 parts Live eel 80-120 servings Angelica 30-80 servings Paeoniae Rubra 30-80 parts Danshen 30-80 parts Elderberry 80-120 servings Natural copper 80-120 parts Crab 80-120 servings Rhubarb 30-80 parts Roasted horse money 30-80 parts 10-40 parts of peach kernel Safflower 10-40 parts Chuanxiong 30-80 parts Zhichuan black 30-80 servings Oysters 80-120 servings 2. The above-mentioned pharmaceutical composition according to claim 1, characterized in that the weight ratio of each component is: Ginseng 50 servings Lamb bones 50 parts Rehmannia 50 servings Live eel 100 servings Angelica 50 servings Radix Paeoniae Alba 50 parts Danshen 50 parts elderberry 100 servings Natural copper 100 parts Crab 100 servings rhubarb 50 parts Roasted horse money 50 parts 15 servings of peach kernels 15 servings of safflower Chuanxiong 50 parts Zhichuan black 50 servings Oysters 100 servings 3. A pharmaceutical preparation, characterized in that the pharmaceutical composition as claimed in claim 1 is used as a raw material component. 4. The pharmaceutical preparation according to claim 3, characterized in that the preparation also contains excipients.