CN1319559C - Pharmaceutical composition for treating muscle and bone pain and preparation method thereof - Google Patents
Pharmaceutical composition for treating muscle and bone pain and preparation method thereof Download PDFInfo
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- CN1319559C CN1319559C CNB2005100722846A CN200510072284A CN1319559C CN 1319559 C CN1319559 C CN 1319559C CN B2005100722846 A CNB2005100722846 A CN B2005100722846A CN 200510072284 A CN200510072284 A CN 200510072284A CN 1319559 C CN1319559 C CN 1319559C
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Abstract
The invention discloses a pharmaceutical composition for treating muscle and bone pain, which is prepared from rhubarb horsetails, pilose antler, red ginseng, Chinese angelica root, dried orange peel, notoginseng, licorice root, indomethacin and VB1、VB2、VB6And (4) forming. The invention has the efficacies of treating both principal and secondary aspect of disease, strengthening body resistance and eliminating evil, and eliminating various diseases, and has obvious effect on treating various kinds of muscle and bone pain.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of bones and muscles pain and preparation method thereof.
Background technology
The medicine of treatment bones and muscles pain is generally oral medicine at present, and Chinese herbal medicine need be brewed into decoction oral mostly, and troublesome poeration all has drawbacks such as damage taste in various degree.Normally used SHANGSHI ZHITONG GAO because the restriction of its dose can only play mitigation to the affected part, can not be taken stopgap measures and effect a permanent cure.
Technology contents
The object of the invention is to provide a kind of pharmaceutical composition that the treatment bones and muscles pain is had remarkable result and can take stopgap measures and can effect a permanent cure.
Another purpose of the present invention is to provide a kind of preparation of drug combination method for the treatment of bones and muscles pain.
The present invention is achieved through the following technical solutions: choose crude drug
Radix Et Rhizoma Rhei 30-90 weight portion system Cornu Cervi Pantotrichum 25-75 weight portion Radix Ginseng Rubra 15-45 weight portion
Radix Angelicae Sinensis 15-45 weight portion Pericarpium Citri Reticulatae 10-30 weight portion horsewhip Radix Notoginseng 5-15 weight portion
Radix Glycyrrhizae 5-15 weight portion indomethacin 0.8-2.5 weight portion VB
10.35-1.05 weight portion
VB
20.17-0.52 weight portion VB
60.35-1.05 weight portion
The optimum ratio of the present composition is: choose crude drug
Radix Et Rhizoma Rhei 60 weight portion system Cornu Cervi Pantotrichums 50 weight portion Radix Ginseng Rubra 30 weight portions
Radix Angelicae Sinensis 30 weight portion Pericarpium Citri Reticulataes 20 weight portion horsewhip Radix Notoginseng 10 weight portions
Radix Glycyrrhizae 10 weight portion indomethacins 1.75 weight portion VB
10.7 weight portion
VB
20.35 weight portion VB
60.7 weight portion
The conventional adjuvant that pharmaceutical composition of the present invention adds is pharmaceutically made clinical acceptable forms, as in pill, tablet, suppository, capsule, granule, spray, ointment, emplastrum or the ointment any.
Preparation method of the present invention is: Radix Et Rhizoma Rhei, system Cornu Cervi Pantotrichum, Radix Ginseng Rubra, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, horsewhip Radix Notoginseng, Radix Glycyrrhizae are gone into calorstat and dry, pulverize; With indomethacin, VB
1, VB
2, VB
6Pulverize; All medicated powder are gone into to sterilize in the container and even; 115-345 weight portion Mel is boiled into refined honey; Refined honey and medicated powder blending are knead, make honeyed pill with the honeyed pill machine; Going into calorstat dries and makes pill.
The effect that the present invention has that giving consideration to both the incidental and fundamental, curb pins are controlled, strengthening body resistance and dispelling evil, all diseases can remove is especially remarkable to treating all kinds of bones and muscles pain person effects.
Following experimental example is used to further specify the present invention:
The present invention's " intercalation specimen ball of Fructus Pruni " treats bones and muscles pain 4991 examples over nearly 12 years, clinical report is as follows:
One, physical data
In the 4991 routine cases, cervical spondylosis 511 examples wherein, male 216 examples, women 295 examples; Sick 1535 examples of lumbar vertebra hyperosteogeny, wherein male 609 examples, women 926 examples; Prolapse of lumbar intervertebral disc 849 examples, male 420 examples, women 429 examples; Sciatica 878 examples, male 381 examples, women 497 examples; Gout 51 examples, male 20 examples, women 31 examples; Rheumatism 167 examples, male 66 examples, women 101 examples; Rheumatoid 87 examples, male 2 examples, women 85 examples; Brachial plexus neuralgia 370 examples, male 151 examples, women 219 examples; Knee osteoarthritis 534 examples, male 208 examples, women 326 examples; Calcanean spur 9 examples are the women.
Two, Therapeutic Method
The present invention's " intercalation specimen ball of Fructus Pruni " composition of writing out a prescription: Radix Et Rhizoma Rhei 60g, system Cornu Cervi Pantotrichum 50g, Radix Ginseng Rubra 30g, Radix Angelicae Sinensis 30g, Pericarpium Citri Reticulatae 20g, horsewhip Radix Notoginseng 10g, Radix Glycyrrhizae 10g, indomethacin 1.75g, VB
10.7g, VB
20.35g, VB
60.7g.
Preparation method:
Radix Et Rhizoma Rhei, system Cornu Cervi Pantotrichum, Radix Ginseng Rubra, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, horsewhip Radix Notoginseng, Radix Glycyrrhizae are gone into calorstat and dry, pulverize; With indomethacin, VB
1, VB
2, VB
6Pulverize; All medicated powder are gone into to sterilize in the container and even; 230g Mel is boiled into refined honey; Refined honey and medicated powder blending are knead, make honeyed pill with the honeyed pill machine; Going into calorstat dries and makes pill, every 166mg.
Usage and consumption:
The present invention's " specimen ball " is oral immediately in after the meal: control acute sick and wounded each 10-20 grain, and every day 1-3 time, available 1-3 days, control chronic sick and wounded every day 1-2 time, 15 for the first time, successively decrease after the improvement 1 at every turn, reduce to till 1 and the sick and wounded recovery from illness.
Three, therapeutic outcome (seeing the following form)
| Cervical spondylosis | The lumbar vertebra hyperosteogeny disease | Prolapse of lumbar intervertebral disc | Sciatica | Gout | Rheumatism | Rheumatoid | Brachial plexus neuralgia | Knee osteoarthritis | Calcanean spur | Add up to | ||
| Eradicate painful number | 146 | 498 | 266 | 251 | 9 | 4 | 122 | 267 | 1 | 1564 | ||
| Wherein | The man | 65 | 213 | 125 | 105 | 5 | 51 | 105 | 669 | |||
| The woman | 81 | 285 | 141 | 146 | 4 | 4 | 71 | 162 | 1 | 895 | ||
| The produce effects number | 185 | 575 | 294 | 417 | 32 | 76 | 58 | 113 | 166 | 5 | 1921 | |
| Wherein | The man | 89 | 184 | 136 | 152 | 11 | 27 | 2 | 44 | 74 | 719 | |
| The woman | 96 | 391 | 158 | 265 | 21 | 49 | 56 | 69 | 92 | 5 | 1202 | |
| Good revolution | 168 | 428 | 262 | 198 | 7 | 58 | 22 | 108 | 94 | 2 | 1347 | |
| Wherein | The man | 58 | 199 | 148 | 120 | 3 | 24 | 45 | 28 | 625 | ||
| The woman | 110 | 229 | 114 | 78 | 4 | 34 | 22 | 63 | 66 | 2 | 722 | |
| Invalid number | 12 | 34 | 27 | 12 | 3 | 33 | 3 | 27 | 7 | 1 | 159 | |
| Wherein | The man | 4 | 13 | 11 | 4 | 1 | 15 | 11 | 1 | 60 | ||
| The woman | 8 | 21 | 16 | 8 | 2 | 18 | 3 | 16 | 6 | 1 | 99 | |
| Total effective rate % | 97.65 | 97.78 | 96.81 | 98.63 | 94.11 | 80.23 | 96.55 | 92.70 | 98.68 | 88.88 | 96.81 | |
| Eradicate misery and obvious effective rate % | 64.77 | 69.90 | 65.95 | 76.08 | 80.39 | 45.50 | 71.26 | 63.51 | 81.08 | 66.66 | 69.83 | |
| Eradicate painful rate % | 28.57 | 32.44 | 31.33 | 28.58 | 17.64 | 4.59 | 32.97 | 5 | 11.11 | 31.34 | ||
Four, discuss
The present invention's " specimen ball " is monarch with the cathartic drug Radix Et Rhizoma Rhei with multiple function such as blood circulation promoting and blood stasis dispelling, is minister with the YANG invigorating principal agent system Cornu Cervi Pantotrichum of kidney-Yang invigorating, benefiting essence-blood, bone and muscle strengthening, is aided with the blood of regulating the flow of vital energy, transfers the product of all medicines, reaches the purpose that makes human body yin-yang balancing.
Five, case
Case 1: recklessly * *, man, 32 years old, too floating people from town, Linli County, Hunan Province, consultation time: 9: 15 morning of on November 1st, 1997.
The main suit: waist lower limb severe pain can not paralysed for 2 weeks.
History of present illness: before 2 weeks, the patient is forced to stop to work because of removing the thing lumbago, and can not get up inferior morning, and low back is to left buttocks, the thigh rear side, outside distending pain loses self care ability unbearably behind the shank, and once how tame medical institutions smelting treatment be invalid in the locality, in the morning on the same day to Changde City * * the People's Hospital goes to a doctor, and open the notice of being admitted to hospital, and the treatment that makes arrangements for surgery, family numbers of patients is sent the patient here my institute's prescription on individual diagnosis upon somebody's introduction.
History of past illness: the tuberculosis of spine medical history is arranged.
Family history: no lumbar spondylosis and skelalgia family history.
Personal history: special hobby such as no tobacco and wine.
Physical examination: because of severe pain too far, moving its clothing then pain can't bear speech, so reexamine after 2 hours eat 15 of the present invention's " intercalation specimen ball of Fructus Pruni " earlier: T37.1 ℃, P84 time/minute, the BP110/75mmhg body of the tongue is light red, tongue is bored with in vain, deep-thready pulse, L4/5, L5/S
1Intervertebral place tenderness is obvious, directly lifts left lower limb test positive (＜15
0).
Laboratory and special examined: CT:L4/5, L5/S
1Intervertebral disc back left is outstanding.
Tentative diagnosis:
The traditional Chinese medical science: rheumatism involving the bone
Doctor trained in Western medicine: prolapse of lumbar intervertebral disc compressing sciatica.
Handle: clothes the present invention's " intercalation specimen ball of Fructus Pruni " 400g (2400).
Usage: every day 2 times, it is oral to press diminishing method 15-1 grain.
Follow up a case by regular visits to: the medication walking of can standing in 3 hours, pain disappears substantially after January, can do farm work, and 7 years so far are surplus, recurrence.
Case 2: sieve * *, man, 5 years old, the sweet village people of factory in Gongan County, Hubei, consultation time: 37 minutes 2 pms of on June 27th, 2002, during prescription on individual diagnosis in the left side, that the third finger and carpal joint swelling and pain have reached May is surplus, once went to * * county people's hospital with * * institute of traditional Chinese medicine can not make a definite diagnosis, my institute is that infant is taken the present invention's " specimen ball " every day 2 times, each 5-1 grain, and oral January, posterior joint ended swollen disappearing bitterly, change clothes every days 2 times, each 1, when student's health check-up in 2003, its immunologic function and parts of body situation are all normal.
Case 3: Tang * *, man, 94 years old, Anxiang County people from shipping company, go to a doctor the date: 9: 27 on the 28th January in 2005, knee-joint pain JIUYUE in a left side once used the goldentop Radix Fissistigmatis Oldhamii invalid during prescription on individual diagnosis, intermittence was beaten 4 all garters, detumescence when beating, the stopping time is pain again, takes 240 of the present invention's " specimen ball ", pain is ended swollen disappearing, so far not recurrence.
Following embodiment is used to further specify the present invention:
Embodiment 1
Radix Et Rhizoma Rhei 60kg system Cornu Cervi Pantotrichum 50kg Radix Ginseng Rubra 30kg Radix Angelicae Sinensis 30kg
Pericarpium Citri Reticulatae 20kg horsewhip Radix Notoginseng 10kg Radix Glycyrrhizae 10kg indomethacin 1.75kg
VB
1 0.7kg VB
2 0.35kg VB
6 0.7kg
Radix Et Rhizoma Rhei, system Cornu Cervi Pantotrichum, Radix Ginseng Rubra, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, horsewhip Radix Notoginseng, Radix Glycyrrhizae are gone into calorstat and dry, pulverize; With indomethacin, VB
1, VB
2, VB
6Pulverize; All medicated powder are gone into to sterilize in the container and even; 230 kilograms of Mel are boiled into refined honey; Refined honey and medicated powder blending are knead, make honeyed pill with the honeyed pill machine; Going into calorstat dries and makes pill, every 166mg.Control acute sick and wounded each 10 1 20, every day 1-3 time, available 1-3 days, control chronic sick and wounded every day 1-2 time, 15 for the first time, successively decrease after the improvement 1 at every turn, reduce to till 1 and the sick and wounded recovery from illness.
Embodiment 2
Radix Et Rhizoma Rhei 40kg system Cornu Cervi Pantotrichum 65kg Radix Ginseng Rubra 20kg Radix Angelicae Sinensis 40kg
Pericarpium Citri Reticulatae 15kg horsewhip Radix Notoginseng 12kg Radix Glycyrrhizae 8kg indomethacin 2kg
VB
1 0.5kg VB
2 0.45kg VB
6 1kg
Said medicine technology is routinely made tablet.
Embodiment 3
Radix Et Rhizoma Rhei 80kg system Cornu Cervi Pantotrichum 35kg Radix Ginseng Rubra 40kg Radix Angelicae Sinensis 20kg
Pericarpium Citri Reticulatae 25kg horsewhip Radix Notoginseng 7kg Radix Glycyrrhizae 13kg indomethacin 1kg
VB
1 1kg VB
2 0.2kg VB
6 0.5kg
Said medicine technology is routinely made capsule.
Claims (9)
1, a kind of pharmaceutical composition for the treatment of bones and muscles pain is characterized in that the crude drug of this pharmaceutical composition consists of:
Radix Et Rhizoma Rhei 30-90 weight portion system Cornu Cervi Pantotrichum 25-75 weight portion Radix Ginseng Rubra 15-45 weight portion
Radix Angelicae Sinensis 15-45 weight portion Pericarpium Citri Reticulatae 10-30 weight portion horsewhip Radix Notoginseng 5-15 weight portion
Radix Glycyrrhizae 5-15 weight portion indomethacin 0.8-2.5 weight portion VB
10.35-1.05 weight portion
VB
20.17-0.52 weight portion VB
60.35-1.05 weight portion.
2, pharmaceutical composition according to claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:
Radix Et Rhizoma Rhei 60 weight portion system Cornu Cervi Pantotrichums 50 weight portion Radix Ginseng Rubra 30 weight portions
Radix Angelicae Sinensis 30 weight portion Pericarpium Citri Reticulataes 20 weight portion horsewhip Radix Notoginseng 10 weight portions
Radix Glycyrrhizae 10 weight portion indomethacins 1.75 weight portion VB
10.7 weight portion
VB
20.35 weight portion VB
60.7 weight portion.
3, pharmaceutical composition according to claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:
Radix Et Rhizoma Rhei 40 weight portion system Cornu Cervi Pantotrichums 65 weight portion Radix Ginseng Rubra 20 weight portions
Radix Angelicae Sinensis 40 weight portion Pericarpium Citri Reticulataes 15 weight portion horsewhip Radix Notoginseng 12 weight portions
Radix Glycyrrhizae 8 weight portion indomethacins 2 weight portion VB
10.5 weight portion
VB
20.45 weight portion VB
61 weight portion.
4, pharmaceutical composition according to claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:
Radix Et Rhizoma Rhei 80 weight portion system Cornu Cervi Pantotrichums 35 weight portion Radix Ginseng Rubra 40 weight portions
Radix Angelicae Sinensis 20 weight portion Pericarpium Citri Reticulataes 25 weight portion horsewhip Radix Notoginseng 7 weight portions
Radix Glycyrrhizae 13 weight portion indomethacins 1 weight portion VB
11 weight portion
VB
20.2 weight portion VB
60.5 weight portion.
5,, it is characterized in that the conventional adjuvant that said composition adds pharmaceutically makes the dosage form of clinical acceptance according to claim 1,2,3 or 4 described pharmaceutical compositions.
6, pharmaceutical composition according to claim 5 is characterized in that said composition makes any in pill, tablet, suppository, capsule, granule, spray, ointment, emplastrum or the ointment.
7, according to claim 1,2,3 or 4 described pharmaceutical compositions, the preparation method that it is characterized in that said composition is for going into Radix Et Rhizoma Rhei, system Cornu Cervi Pantotrichum, Radix Ginseng Rubra, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, horsewhip Radix Notoginseng, Radix Glycyrrhizae calorstat and dry, pulverize; With indomethacin, VB
1, VB
2, VB
6Pulverize; All medicated powder are gone into to sterilize in the container and even; 115-345 weight portion Mel is boiled into refined honey; Refined honey and medicated powder blending are knead, make honeyed pill with the honeyed pill machine; Going into calorstat dries and makes pill.
8, preparation of drug combination method according to claim 7 is characterized in that this preparation method is: Radix Et Rhizoma Rhei, system Cornu Cervi Pantotrichum, Radix Ginseng Rubra, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, horsewhip Radix Notoginseng, Radix Glycyrrhizae are gone into calorstat and dry, pulverize; With indomethacin, VB
1, VB
2, VB
6Pulverize; All medicated powder are gone into to sterilize in the container and even; 230 weight portion Mel are boiled into refined honey; Refined honey and medicated powder blending are knead, make honeyed pill with the honeyed pill machine; Going into calorstat dries and makes pill.
9, according to claim 1,2, the application of 3 or 4 described pharmaceutical compositions in the medicine of preparation treatment bones and muscles pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100722846A CN1319559C (en) | 2005-05-27 | 2005-05-27 | Pharmaceutical composition for treating muscle and bone pain and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100722846A CN1319559C (en) | 2005-05-27 | 2005-05-27 | Pharmaceutical composition for treating muscle and bone pain and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1698789A CN1698789A (en) | 2005-11-23 |
| CN1319559C true CN1319559C (en) | 2007-06-06 |
Family
ID=35475143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100722846A Expired - Fee Related CN1319559C (en) | 2005-05-27 | 2005-05-27 | Pharmaceutical composition for treating muscle and bone pain and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1319559C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145149B (en) * | 2010-02-07 | 2012-03-07 | 张向阳 | Plaster for treating arthralgia and myalgia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1530122A (en) * | 2003-03-12 | 2004-09-22 | 湘潭钢铁集团有限公司 | Chinese medicine for treating injury |
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2005
- 2005-05-27 CN CNB2005100722846A patent/CN1319559C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1530122A (en) * | 2003-03-12 | 2004-09-22 | 湘潭钢铁集团有限公司 | Chinese medicine for treating injury |
Non-Patent Citations (3)
| Title |
|---|
| 中药治疗腰椎间盘突出症的近况及评价 农勇安，刘祖清，叶宗昌，颈腰痛杂志，第25卷第4期 2004 * |
| 骨痹临症举隅 张光明，吉林中医药，第24卷第7期 2004 * |
| 骨痹临症举隅 张光明，吉林中医药，第24卷第7期 2004;中药治疗腰椎间盘突出症的近况及评价 农勇安，刘祖清，叶宗昌，颈腰痛杂志，第25卷第4期 2004 * |
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| Publication number | Publication date |
|---|---|
| CN1698789A (en) | 2005-11-23 |
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