CN1051471C - A kind of pharmaceutical composition for treating osteoporosis - Google Patents
A kind of pharmaceutical composition for treating osteoporosis Download PDFInfo
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- CN1051471C CN1051471C CN97116955A CN97116955A CN1051471C CN 1051471 C CN1051471 C CN 1051471C CN 97116955 A CN97116955 A CN 97116955A CN 97116955 A CN97116955 A CN 97116955A CN 1051471 C CN1051471 C CN 1051471C
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Abstract
Description
本发明是一种治疗骨质疏松症的药物组合物，该组合物的组成为我国的传统中草药，对骨质疏松症的治疗和预防具有良好的功效，本发明还提供了以该组合物制备而成的药剂。属于中药领域。The invention is a pharmaceutical composition for treating osteoporosis. The composition is traditional Chinese herbal medicine in my country, which has good efficacy in the treatment and prevention of osteoporosis. The invention also provides made medicine. It belongs to the field of traditional Chinese medicine.
随着现代生活水平的提高，人口寿命逐渐增长，老年人口越来越多，由此带来的退行性生理疾病-原发性骨质疏松症已经成为老年健康的重要疾病之一。骨质疏松症是一种老年病，常见病，目前国内尚无特效的中药制剂。骨质疏松症的特征是骨量低下，骨组织微结构退化导致骨脆性增加，极易造成腰椎压缩性骨折、股骨颈骨折及手腕部、桡骨骨折。这些骨折，尤其是腰椎骨折，往往在没有明显外力作用下发生，常常表现突然腰背剧痛始被发现。随着人口寿命的增长，老年人数的增多，这种病的危害就越来越严重。因此，寻找一种有效预防和治疗骨质疏松症的中药，是当前医学界的重要课题之一。With the improvement of modern living standards, the life expectancy of the population is gradually increasing, and the elderly population is increasing. The resulting degenerative physiological disease-primary osteoporosis has become one of the important diseases of the health of the elderly. Osteoporosis is a kind of senile disease, a common disease, and there is no specific Chinese medicine preparation in China at present. Osteoporosis is characterized by low bone mass and microarchitectural degradation of bone tissue leading to increased bone fragility, which can easily cause lumbar vertebral compression fractures, femoral neck fractures, wrist and radius fractures. These fractures, especially lumbar fractures, often occur without obvious external force, and often manifest as sudden severe back pain. Along with the growth of population life expectancy, the increase of old people's number, the harm of this disease is just more and more serious. Therefore, finding a kind of Chinese medicine for effectively preventing and treating osteoporosis is one of the important topics in the current medical circle.
本发明目的是开发一种治疗骨质疏松症的药物组合物。The purpose of the present invention is to develop a pharmaceutical composition for treating osteoporosis.
根据中医“肾主骨”的理论，骨质疏松症患者肾虚是病之根本。治病必求于本，且肾虚又有肾阴虚、肾阴虚之分。运用中医辩证施治的原则，按照全国关于肾阴虚、肾阳虚诊断标准，对本病肾阴虚者，补肾阴，益气养血，壮骨舒筋，活血祛瘀止痛。发明人在临床实践中通过大量病例总结，研制出了治疗骨质疏松症偏肾阴虚的药物。According to the theory of "kidney governs bones" in traditional Chinese medicine, kidney deficiency is the root of the disease in patients with osteoporosis. Curing must seek at the root, and kidney deficiency can be divided into kidney-yin deficiency and kidney-yin deficiency. Using the principle of dialectical treatment in traditional Chinese medicine, according to the national diagnostic criteria for kidney yin deficiency and kidney yang deficiency, for patients with kidney yin deficiency in this disease, tonify kidney yin, nourish qi and blood, strengthen bones and relax tendons, promote blood circulation, remove blood stasis and relieve pain. The inventor has developed a medicine for treating osteoporosis partial kidney yin deficiency by summarizing a large number of cases in clinical practice.
本发明药物组合物按重量份计其组成是：The composition of the pharmaceutical composition of the present invention is in parts by weight:
西洋参 20-80份American ginseng 20-80 parts
冬虫夏草 10-40份Cordyceps 10-40 parts
熟地 20-80份Rehmannia 20-80 parts
龟板 30-80份Turtle shell 30-80 servings
当归 30-80份Angelica 30-80 servings
赤芍 30-80份Paeoniae Rubra 30-80 parts
丹参 30-80份Danshen 30-80 parts
接骨木 80-120份Elderberry 80-120 servings
自然铜 80-120份Natural copper 80-120 parts
蟹 80-120份Crab 80-120 servings
牡蛎 80-120份Oysters 80-120 servings
大黄 30-80份Rhubarb 30-80 parts
炙马钱子 30-80份Roasted horse money 30-80 servings
桃仁 30-80份30-80 servings of peach kernel
红花 10-40份Safflower 10-40 parts
本发明所述的药物组合物其优选重量配比为：Its preferred weight ratio of the pharmaceutical composition of the present invention is:
西洋参 50份American ginseng 50 servings
冬虫夏草 25份Cordyceps sinensis 25 servings
熟地 50份Shudi 50 copies
龟板 50份Turtle shell 50 parts
当归 50份Angelica 50 servings
赤芍 50份Radix Paeoniae Rubra 50 parts
丹参 50份Danshen 50 parts
接骨木 100份elderberry 100 servings
自然铜 100份Natural Copper 100 parts
蟹 100份Crab 100 servings
牡蛎 100份Oysters 100 servings
大黄 50份rhubarb 50 parts
炙马钱子 50份Roasted horse money 50 copies
桃仁 50份50 servings of peach kernels
红花 15份15 servings of safflower
本发明所述的药物组合物，可以按照常规的制剂工艺，制备成任何一种适合于临床上使用的药物剂型。如，丸剂、片剂、胶囊剂、散记、糖浆剂、口服液、混悬剂、颗粒剂等。The pharmaceutical composition of the present invention can be prepared into any pharmaceutical dosage form suitable for clinical use according to conventional preparation techniques. For example, pills, tablets, capsules, powders, syrups, oral liquids, suspensions, granules, etc.
在制备成本发明上述的药物剂型过程中，可以加入常规的药物赋形剂，例如，崩解剂、粘合剂、调味剂、防腐剂、填充剂、增溶剂、助溶剂、润滑剂、色素等。In the process of preparing the above-mentioned pharmaceutical dosage forms of the present invention, conventional pharmaceutical excipients can be added, for example, disintegrants, binders, flavoring agents, preservatives, fillers, solubilizers, solubilizers, lubricants, pigments, etc. .
本发明药物丸剂(商品名为勇骨丹)的制备方法是：The preparation method of medicine pill of the present invention (trade name is brave bone pill) is:
将西洋参、冬虫夏草、蟹速冻干燥，为末，保持生物活性。自然铜、牡蛎、龟板、大黄、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上述药粉混合，炼蜜为丸，每丸重6克。American ginseng, cordyceps sinensis, and crab are quick-freeze-dried and made into powder to maintain biological activity. Natural copper, oyster, tortoise shell, rhubarb, and sunburst are ground into fine powder, and the rest of the medicines are made into clear ointment according to the general principles of pharmacopoeia preparations, and then mixed with the above-mentioned medicine powder, refined into honey and made into pills, each weighing 6 grams.
本发明药物的功效是：补肾阴、益气养血、壮骨舒筋、活血化瘀。The effects of the medicine of the present invention are: nourishing kidney yin, nourishing qi and nourishing blood, strengthening bones and relaxing tendons, promoting blood circulation and removing blood stasis.
主治：肾阴虚型骨质疏松症。Indications: kidney yin deficiency type osteoporosis.
临床应用：骨质疏松、腰背酸痛、两膝酸软、骨折疼痛兼见头晕眼花、潮热盗汗、咽干口燥、舌红少苔、脉细数者，每次服一丸，每日三次，饭后甜醋25毫升兑水适量送服，30天为一疗程。Clinical application: Osteoporosis, low back pain, sore knees, fracture pain and dizziness, hot flashes and night sweats, dry throat, red tongue with little moss, rapid pulse, take one pill each time, three times a day, Take 25ml of sweet vinegar mixed with water in appropriate amount after meal, 30 days as a course of treatment.
自1995年至1997年，应用本发明药物治疗骨质疏松症病人30例。30例病人骨X线平片显示：胸椎、髋骨均有不同程度骨密度降低。其中，6例腰椎压缩性骨折，4例股骨颈骨折，1例桡骨骨折，1例髋骨骨折。30例病人均有不同程度腰背疼痛病史、膝关节及髋部疼痛病史。From 1995 to 1997, 30 patients with osteoporosis were treated with the medicine of the present invention. The bone X-ray plain films of 30 patients showed that the bone density of the thoracic spine and hip bones decreased in varying degrees. Among them, there were 6 cases of lumbar compression fracture, 4 cases of femoral neck fracture, 1 case of radial fracture, and 1 case of hip fracture. All 30 patients had medical history of low back pain, knee joint and hip pain in different degrees.
对治疗结果的疗效评定标准是：The curative effect evaluation standard of treatment result is:
显效为用药后疼痛完全消失，活动功能显著增进；Significant effect refers to the complete disappearance of pain after medication, and significant improvement in activity function;
有效为用药后疼痛减轻，活动功能改善；It is effective for pain relief and improvement of activity function after medication;
无效为用药后疼痛未减轻，仍需服用其他药物。Ineffective means that the pain has not been alleviated after taking the medicine, and other medicines still need to be taken.
按上述疗效评价标准，治疗结果如下表：
本发明药物组合物治疗骨质疏松症总有效率93％。The total effective rate of the pharmaceutical composition of the present invention in treating osteoporosis is 93%.
实施例1Example 1
西洋参50克 冬虫夏草25克 熟地50克 龟板50克American ginseng 50 grams Cordyceps sinensis 25 grams Rehmannia 50 grams Turtle shell 50 grams
当归 50克 赤芍50克 丹参50克 接骨木100克Angelica 50g Radix Paeoniae Rubra 50g Salvia miltiorrhiza 50g Elderberry 100g
自然铜100克 蟹 100克 牡蛎100克 大黄50克Natural Copper 100g Crab 100g Oyster 100g Rhubarb 50g
炙马钱子50克 桃仁50克 红花15克50 grams of roasted horse money 50 grams of peach kernels 15 grams of safflower
按照处方量取西洋参、冬虫夏草、蟹速冻干燥，为末，保持生物活性。将自然铜、牡蛎、龟板、大黄、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上药粉混合，炼蜜为丸，制成100丸，每丸重6克。American ginseng, cordyceps sinensis and crab are taken according to the prescription and freeze-dried to make the powder to maintain biological activity. Grind natural copper, oyster, tortoise shell, rhubarb, and sunburst into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined with honey to make pills, and made into 100 pills, each weighing 100 pills. 6 grams.
实施例2Example 2
西洋参60克 冬虫夏草30克 熟地40克 龟板40克American ginseng 60 grams Cordyceps sinensis 30 grams Rehmannia 40 grams Turtle shell 40 grams
当归70克 赤芍30克 丹参40克 接骨木80克Angelica 70g Radix Paeoniae Rubra 30g Salvia miltiorrhiza 40g Elderberry 80g
自然铜90克 蟹 90克 牡蛎90克 大黄40克Natural Copper 90g Crab 90g Oyster 90g Rhubarb 40g
炙马钱子50克 桃仁60克 红花25克50 grams of roasted horse money 60 grams of peach kernels 25 grams of safflower
按照处方量取西洋参、冬虫夏草、蟹速冻干燥，为末，保持生物活性。自然铜、牡蛎、龟板、大黄、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上药粉混合，炼蜜为丸，每丸重6克。American ginseng, cordyceps sinensis and crab are taken according to the prescription and freeze-dried to make the powder to maintain biological activity. Natural copper, oyster, tortoise shell, rhubarb, and sunburst are ground into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into pills, each weighing 6 grams.
实施例3Example 3
西洋参80克 冬虫夏草10克 熟地80克 龟板80克American ginseng 80 grams Cordyceps sinensis 10 grams Rehmannia 80 grams Turtle shell 80 grams
当归40克 赤芍50克 丹参80克 接骨木120克40 grams of angelica, 50 grams of red peony root, 80 grams of salvia miltiorrhiza, 120 grams of elderberry
自然铜90克 蟹 100克 牡蛎100克 大黄30克Natural Copper 90g Crab 100g Oyster 100g Rhubarb 30g
炙马钱子40克 桃仁30克 红花20克40 grams of roasted horse money 30 grams of peach kernels 20 grams of safflower
按照处方量取西洋参、冬虫夏草、蟹速冻干燥，为末，保持生物活性。自然铜、牡蛎、龟板、大黄、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上药粉混合，炼蜜为丸，制成100丸，每丸重6克。American ginseng, cordyceps sinensis and crab are taken according to the prescription and freeze-dried to make the powder to maintain biological activity. Natural copper, oyster, tortoise shell, rhubarb, and sunburst are ground into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, and then mixed with the above medicinal powder, refined with honey to make pills, and made into 100 pills, each weighing 6 gram.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116955A CN1051471C (en) | 1997-09-29 | 1997-09-29 | A kind of pharmaceutical composition for treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116955A CN1051471C (en) | 1997-09-29 | 1997-09-29 | A kind of pharmaceutical composition for treating osteoporosis |
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| Publication Number | Publication Date |
|---|---|
| CN1179978A CN1179978A (en) | 1998-04-29 |
| CN1051471C true CN1051471C (en) | 2000-04-19 |
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| CN97116955A Expired - Fee Related CN1051471C (en) | 1997-09-29 | 1997-09-29 | A kind of pharmaceutical composition for treating osteoporosis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7311919B2 (en) * | 2003-04-17 | 2007-12-25 | Simpson Biotech Co., Ltd. | Agents for treating osteoporosis and inhibiting osteoclast formation |
| CN103349123A (en) * | 2013-07-22 | 2013-10-16 | 北京绿源求证科技发展有限责任公司 | Food health preserving tea electuary for preventing osteoporosis |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391497C (en) * | 2004-02-11 | 2008-06-04 | 辽宁中医学院 | Nanometer Chinese traditional medicine for treating osteoporosis |
| CN101138597B (en) * | 2007-08-31 | 2010-06-23 | 澳门科技大学 | A traditional Chinese medicine preparation for preventing and treating osteoporosis and its preparation method |
| CN102614339A (en) * | 2011-06-07 | 2012-08-01 | 李学朋 | Preparation method of Chinese patent medicine used for treating osteoporosis |
| CN104367629A (en) * | 2014-11-06 | 2015-02-25 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating osteoporosis |
-
1997
- 1997-09-29 CN CN97116955A patent/CN1051471C/en not_active Expired - Fee Related
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| Title |
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| 中医杂志1992,23(11) 1992. 1. 1 梁立等,补肾中药治疗骨质节疏松症临床观察 * |
| 中医杂志1992,23(9) 1992. 1. 1 王林元,新伤膏治疗髌骨软骨软化症76例报告 * |
| 实用儿科临床杂志1990,5(4) 1990. 1. 1 尹钟洙,龙牡壮骨冲剂药理学研究 * |
| 实用儿科临床杂志1990,5(4) 1990. 1. 1 尹钟洙,龙牡壮骨冲剂药理学研究;中医杂志1992,23(11) 1992. 1. 1 梁立等,补肾中药治疗骨质节疏松症临床观察;中医杂志1992,23(9) 1992. 1. 1 王林元,新伤膏治疗髌骨软骨软化症76例报告 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7311919B2 (en) * | 2003-04-17 | 2007-12-25 | Simpson Biotech Co., Ltd. | Agents for treating osteoporosis and inhibiting osteoclast formation |
| US7387781B2 (en) | 2003-04-17 | 2008-06-17 | Simpson Biotech Co., Ltd. | Agents for treating osteoporosis and inhibiting osteoclast formation |
| CN103349123A (en) * | 2013-07-22 | 2013-10-16 | 北京绿源求证科技发展有限责任公司 | Food health preserving tea electuary for preventing osteoporosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1179978A (en) | 1998-04-29 |
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