CN1175873C - Preparation technology of - Google Patents
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- Publication number
- CN1175873C CN1175873C CNB021341486A CN02134148A CN1175873C CN 1175873 C CN1175873 C CN 1175873C CN B021341486 A CNB021341486 A CN B021341486A CN 02134148 A CN02134148 A CN 02134148A CN 1175873 C CN1175873 C CN 1175873C
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- China
- Prior art keywords
- fine powder
- thick paste
- poria
- concentrated
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000005516 engineering process Methods 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title description 2
- 229920005989 resin Polymers 0.000 claims abstract description 22
- 239000011347 resin Substances 0.000 claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 claims abstract description 13
- 239000008187 granular material Substances 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 76
- 239000000843 powder Substances 0.000 claims description 60
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 239000000706 filtrate Substances 0.000 claims description 30
- 238000001035 drying Methods 0.000 claims description 23
- 238000002425 crystallisation Methods 0.000 claims description 21
- 230000008025 crystallization Effects 0.000 claims description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 20
- 238000004821 distillation Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 13
- 239000000047 product Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 230000000274 adsorptive effect Effects 0.000 claims description 9
- 239000009220 Liuwei Dihuang Decoction Substances 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000003463 adsorbent Substances 0.000 claims description 3
- 239000003480 eluent Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 4
- 150000004676 glycans Chemical class 0.000 abstract description 2
- 229920001282 polysaccharide Polymers 0.000 abstract description 2
- 239000005017 polysaccharide Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 2
- 239000002775 capsule Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000012567 medical material Substances 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a technique for producing Liuwei Dihuang capsules. Specified traditional Chinese medicinal materials are respectively extracted and concentrated, macroporous resins, etc. are used for extraction, and thus, effective ingredients are fully kept. Compared with the prior art, the simple and feasible production method of the present invention has simple technique, obtained medicines are further concentrated and refined, medicine effect is concentrated, protruding and obvious, the medicines can be only taken twice with one granule every time, and the dosage of taking the medicines is one time less than that of taking medicines obtained from the prior art. Effluent liquid flowing from resin columns is collected and processed, the method completely keeps polysaccharide in the traditional Chinese medicinal materials though a certain procedure is added, and the effect of finished products is enhanced.
Description
Technical field: the present invention is a kind of production technology of LIUWEIDIHUANG JIAONANG, belongs to the production of medicine
Technical field.
Technical background: the main effect of LIUWEIDIHUANG JIAONANG is enriching yin and nourishing kidney, is used for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, symptom such as quench one's thirst; Traditional production method adopts more common technology with all medical material mix homogeneously, and its efficacy of a drug deficiency needs the patient to take 16 day and just can reach therapeutic effect; There is " production method of Chinese medicine Liuwei Dihuang preparation " to apply for national inventing patent in the Chinese patent application, this technology has solved the purified inadequately problem of active ingredient of prior art Chinese crude drug, the quantity of obeying 8 the product needs of patients day of original technology production is reduced to the level that only needs 4 of day clothes, just can reaches identical therapeutic effect; But according to existing technology still the active ingredient of this medicine further can be concentrated, refine, and obtained success through test repeatedly.
Summary of the invention: the objective of the invention is to: the production technology that a kind of LIUWEIDIHUANG JIAONANG is provided, this method is according to the different characteristics of these medical materials self, choose corresponding fabrication and processing method and utilize Amberlyst process to extract active ingredient in the medical material, make medicine refine more like this, drug effect is more remarkable, reduces user's the quantity of taking, and only need 2 every day, make the patient be easy to more accept, alleviate patients ' psychological, physiological fear; The present invention is achieved in that the medical material of use is: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, and method is:
A, the Poria powder of 30%-40% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, pass through macroporous adsorptive resins, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products; More specific technology is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni adds the alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, also carry out crystallization according to conventional way, filter then, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, ethanol elution with 70% reclaims ethanol, is concentrated into the thick paste shape, add the Poria thick paste that has obtained, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, at Cortex Moutan extract fine powder that adds acquisition and an amount of conventional adjuvant, in incapsulating behind the mix homogeneously, get 1000 granule products.More specifically technology is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni decocts with water three times, each 1 hour, filter, medicinal residues add 90% alcohol reflux secondary of 5 times of amounts, each 1 hour, filter, filtrate recycling ethanol is concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, and make its crystallization, filter, crystallization washes with water, cold drying is ground into fine powder, the aqueous solution after the distillation and Cortex Moutan medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate by macroporous adsorptive resins, is collected trickle from resin column, suitably concentrate the back and add isopyknic 95% ethanol, stir, left standstill 24 hours, filter, the taking precipitate cold drying, pulverize, with 70% ethanol elution, eluent is incorporated Fructus Corni backflow recovery ethanol into adsorbent resin, be concentrated into the thick paste shape, add the Poria thick paste and the fine powder that have obtained, mix homogeneously, drying, be ground into powder again, add Cortex Moutan extract fine powder and resin column effluent extract, in incapsulating behind the mix homogeneously, get 1000 granule products.Compared with prior art: simple, the easy row of production method technology provided by the invention, the medicine that obtains further concentrates, refine, drug effect is concentrated more, is given prominence to, the efficacy of a drug is more obvious, take this medicine, only need every day secondary, each 1 to get final product, the medicine that obtains than prior art lacks the multiple amount of taking; Employing will collect, handle by effusive effluent from resin column, though increased certain operation, this method has kept the polysaccharide composition in the medical material fully, has improved the effect of manufactured goods.
Embodiments of the invention 1: the regulation according to state-promulgated pharmacopoeia is selected medical material for use: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, concrete grammar is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni adds the alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, ethanol elution with 70% reclaims ethanol, is concentrated into the thick paste shape, add the Poria thick paste that has obtained, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, at Cortex Moutan extract fine powder that adds acquisition and an amount of conventional adjuvant, in incapsulating behind the mix homogeneously, get 1000 granule products.
Embodiments of the invention 2: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, method is:
A, the Poria powder of 40% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, pass through macroporous adsorptive resins, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products.
Embodiments of the invention 3: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 538 grams, method is:
A, the Poria powder of 30% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, cross resin column, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products.
Embodiments of the invention 4: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni decocts with water three times, each 1 hour, filter, medicinal residues add 90% alcohol reflux secondary of 5 times of amounts, each 1 hour, filter, filtrate recycling ethanol is concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, and make its crystallization, filter, crystallization washes with water, cold drying is ground into fine powder, the aqueous solution after the distillation and Cortex Moutan medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate by macroporous adsorptive resins, is collected trickle from resin column, suitably concentrate the back and add isopyknic 95% ethanol, stir, left standstill 24 hours, filter, the taking precipitate cold drying, pulverize, with 70% ethanol elution, eluent is incorporated Fructus Corni backflow recovery ethanol into adsorbent resin, be concentrated into the thick paste shape, add the Poria thick paste and the fine powder that have obtained, mix homogeneously, drying, be ground into powder again, add Cortex Moutan extract fine powder and resin column effluent extract, in incapsulating behind the mix homogeneously, get 1000 granule products.
Claims (3)
1, a kind of production technology of LIUWEIDIHUANG JIAONANG, wherein Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 restrain, Poria 528 restrains, Rhizoma Alismatis 538 grams, it is characterized in that:
A, the Poria powder of 30%-40% weight is broken into fine powder, tails over part and decoct with water merging filtrate, be concentrated into the thick paste shape with remaining Poria,
B, Fructus Corni add alcohol reflux and filter, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape,
C, Cortex Moutan vapor distillation, and in the distillate of collecting, add hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, is ground into fine powder after the drying,
Aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after D, the distillation decocts with water, filtration, merging filtrate, pass through macroporous adsorptive resins, use ethanol elution, reclaim ethanol, be concentrated into the thick paste shape, add the Poria thick paste, Fructus Corni thick paste and the Poria fine powder that have obtained, mixing, drying are ground into fine powder, add the Cortex Moutan extract fine powder of acquisition and an amount of adjuvant again, in incapsulating behind the mix homogeneously, get 1000 granule products.
2, production technology according to the described this LIUWEIDIHUANG JIAONANG of claim 1, it is characterized in that: technology is particularly: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni adds the alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, ethanol elution with 70% reclaims ethanol, is concentrated into the thick paste shape, add the Poria thick paste that has obtained, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, at Cortex Moutan extract fine powder that adds acquisition and an amount of adjuvant, in incapsulating behind the mix homogeneously, get 1000 granule products.
3, according to claim 1, the production technology of 2 described this LIUWEIDIHUANG JIAONANG, it is characterized in that: more specifically technology is: 110 gram Poria powders are broken into fine powder, tailing over part decocts with water three times with remaining 418 gram Poria, each 30 minutes, filter, merging filtrate, be concentrated into the thick paste shape, Fructus Corni decocts with water three times, each 1 hour, filter, medicinal residues add 90% alcohol reflux secondary of 5 times of amounts, each 1 hour, filter, filtrate recycling ethanol, be concentrated into the thick paste shape, the Cortex Moutan vapor distillation, and in the distillate of collecting, add the 1moL/L hydrochloric acid solution, make its crystallization, filter, crystallization washes with water, cold drying, be ground into fine powder, aqueous solution after the distillation and Cortex Moutan medicinal residues and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filters, merging filtrate, pass through macroporous adsorptive resins, collection is trickle from resin column, suitably concentrates the back and adds isopyknic 95% ethanol, stirs, left standstill 24 hours, filter, the taking precipitate cold drying is pulverized, with adsorbent resin with 70% ethanol elution, eluent is incorporated the Fructus Corni backflow into and is reclaimed ethanol, is concentrated into the thick paste shape, adds the Poria thick paste and the fine powder that have obtained, mix homogeneously, drying is ground into powder again, adds Cortex Moutan extract fine powder and resin column effluent extract, in incapsulating behind the mix homogeneously, get 1000 granule products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021341486A CN1175873C (en) | 2002-11-19 | 2002-11-19 | Preparation technology of |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021341486A CN1175873C (en) | 2002-11-19 | 2002-11-19 | Preparation technology of |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1413711A CN1413711A (en) | 2003-04-30 |
| CN1175873C true CN1175873C (en) | 2004-11-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021341486A Expired - Fee Related CN1175873C (en) | 2002-11-19 | 2002-11-19 | Preparation technology of |
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| Country | Link |
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| CN (1) | CN1175873C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104096040A (en) * | 2013-04-14 | 2014-10-15 | 江西普正制药有限公司 | Preparation method of six-ingredient rehmannia capsules |
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN105609639A (en) * | 2015-12-23 | 2016-05-25 | 海安常州大学高新技术研发中心 | Low-temperature preparation method for organic/inorganic hybrid perovskite solar cell |
| CN106214911A (en) * | 2016-08-22 | 2016-12-14 | 湖南康尔佳制药股份有限公司 | A kind of medicine of enriching yin and nourishing kidney and preparation method thereof |
| CN115137786A (en) * | 2022-07-29 | 2022-10-04 | 吉林省民泰制药股份有限公司 | A capsule containing six ingredients with rehmanniae radix and its preparation method |
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2002
- 2002-11-19 CN CNB021341486A patent/CN1175873C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1413711A (en) | 2003-04-30 |
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Effective date of registration: 20041029 Address after: 550004 No. 467 North Road, Guiyang, Guizhou Patentee after: Guizhou Kangna Shengfang Pharmaceutical Co.,Ltd. Address before: 550004, Guizhou province Guiyang City North Road 467, Chen Ping turn Patentee before: Gao Yang |
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