CN1063056C - Oral liquid for relieving pain of cancer patient - Google Patents
Oral liquid for relieving pain of cancer patient Download PDFInfo
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- CN1063056C CN1063056C CN 96118736 CN96118736A CN1063056C CN 1063056 C CN1063056 C CN 1063056C CN 96118736 CN96118736 CN 96118736 CN 96118736 A CN96118736 A CN 96118736A CN 1063056 C CN1063056 C CN 1063056C
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Abstract
The invention relates to an oral liquid for alleviating or relieving pain of cancer patients, which is prepared by mixing and decocting seven pure Chinese herbal medicines of rhizoma ligustici wallichii, angelica, ginger, liquorice, radix aconiti agrestis and salvia miltiorrhiza and thalictrum, and then concentrating, cooling and precipitating the mixture, and has the advantages that: 1. the invention is a pure herbal preparation, without side effect; 2. the analgesic effect is strong; 3. has wide application range and no drug resistance and addiction.
Description
The present invention relates to a kind of oral Chinese medicine medicinal liquid and the production method thereof that can remove or alleviate cancer patient's slight illness.
At present, medically three stepped care methods are being carried out in cancer pain treatment: the first ladder pain is used the agent that relieves the pain of non-Opium class, as: aspirin, acetaminophen etc., the second ladder pain adopts strong Opiate (cocaine), and the 3rd ladder pain adopts strong Opiate (morphine hydrochloride) so that the last dolantin that uses.The advantage of morphine hydrochloride and dolantin is that pain relieving scope indication is wide, and onset time is short, and its shortcoming is addiction and drug resistance promptly to occur about one week of patient's medication.The new drug " pain is ended oral liquid surely " (production of Tonghua, Jilin biochemistry products factory) of listing after announce according to China national medicine general bureau 90 years, but it is mainly used in the pain relieving of alimentary tract cancer, and said medicine all belongs to chemical synthetic drug.
The object of the present invention is to provide a kind ofly with the synthetic oral liquid medicine that can remove or alleviate pain among cancer patients of Chinese herbal medicine, its advantage is: 1. the present invention is a pure Chinese medicinal preparation; 2. there are not addiction and drug resistance; 3. side effect is little.
The objective of the invention is to realize with following technical proposals: a kind of Aitongning oral liquid (for relieving cancer pain), its production technology is:
(1) a that takes by weighing raw material Rhizoma Chuanxiong (30--35 gram) doubly measures, the a of Radix Angelicae Sinensis (35--40 gram) doubly measures, a of Rhizoma Zingiberis Recens (2--5 gram) doubly measures, a of Radix Aconiti Kusnezoffii (5--15 gram) doubly measures, a of Radix Glycyrrhizae (3--8 gram) doubly measures, a of Radix Salviae Miltiorrhizae (10--20 gram) doubly measures, a of Flos Daturae (5--15 gram) doubly measures
(2) with the Rhizoma Chuanxiong that takes by weighing, Radix Angelicae Sinensis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Radix Aconiti Kusnezoffii, Radix Salviae Miltiorrhizae chopping, add its weight 8--12 cold water doubly, soaked after 20-40 minute decoction 20-40 minute,
(3) give the Flos Daturae that adding takes by weighing in the medicinal liquid, continue to decoct 40--80 minute, separating liquid medicine is gone out, it is the medicinal liquid I,
(4) give the water that adds 6--10 times of spice gross weight in the isolated medicinal residues, continue to decoct 40--80 minute, separating liquid medicine is gone out again, it is the medicinal liquid II,
(5) again with adding 4--8 times water of spice total amount in the isolated medicinal residues in (4) and decocting 50--70 minute, separating liquid medicine is gone out, it is the medicinal liquid III again,
(6) three isolated medicinal liquid I, II, III are merged filtration, filtrate decompression is condensed into cream, after the cooling, 95% ethanol that the 2--4 of adding extractum doubly measures makes precipitation, leaves standstill 20--28 hour again, and get supernatant and reclaim ethanol to the extractum shape,
(7) the extractum adding distil water is an amount of, make every milliliter of medicinal liquid contain crude drug 1.5--2.5 gram, and a that adds preservative sodium benzoate (0.2--0.4 gram) doubly measure through stirring, potting, sterilizing promptly gets the alleged Aitongning oral liquid (for relieving cancer pain) of the present invention.
Advantage of the present invention is as follows:
(1) analgesic effect is strong.This medicine belongs to the nervus centralis analgesics, shows through pharmacology's system experimentation 142 routine all kinds of cancer pain patient's clinical observations: (seeing Table)
(2) analgesia time is long.The pain relieving of centering patient with advanced cancer Aitongning oral liquid (for relieving cancer pain) 5--10ml, 10--20 minute can take effect, the analgesia effective time reach 3--4 hour, as the while oral fast can sleep 0.1 the gram, analgesic effect can prolong 7--12 hour.
| Use oral liquid treatment effect of the present invention | Compare with 60 routine dolantin treatments | ||||||
| Alleviation degree disease degree | Alleviate fully | Moderate is alleviated | Do not have and alleviate | Remarkable effective percentage % | Inefficiency % | Remarkable effective percentage % | Inefficiency % |
| Moderate pain 34 examples | 24 | 6 | 4 | 87.3 | 12.7 | 63.3 | 36.7 |
| Severe pain 108 examples | 34 | 60 | 14 | ||||
(3) indication wide and do not have recessive, have no drug resistance.The pain of Aitongning oral liquid (for relieving cancer pain) after to malignant tumor, middle and terminal cancer pain, colic, cholelithiasis pain and trauma operation treats that analgesic effect is good, and this medicinal liquid is through probationary certificate repeatedly: do not have into recessiveness and drug resistance.
Below in conjunction with embodiment the present invention is further described.
Oral liquid production method step of the present invention is as follows:
Rhizoma Chuanxiong 300 grams with select, Radix Angelicae Sinensis 350 grams, Rhizoma Zingiberis Recens 20 grams, Radix Aconiti Kusnezoffii 100 grams, Radix Glycyrrhizae 30 grams, after the Radix Salviae Miltiorrhizae 150 gram choppings, put into extraction pot, add 10 premium on currency and soak half an hour, after decocting half an hour again, add Flos Daturae 150 grams, decocted again 1 hour, isolate the medicinal liquid I, decocted for the second time 1 hour to adding 8 premium on currency in the medicinal residues, isolate the medicinal liquid II, decoct for the third time to adding 6 premium on currency in the medicinal residues again, isolate the medicinal liquid III, with above-mentioned isolated medicinal liquid I, II, III merges also filters, and filtrate decompression is condensed into cream, adds 95% ethanol that the 2--4 of extractum doubly measures again, leave standstill and got supernatant recovery ethanol in 24 hours to the extractum shape, then with extractum adding distil water to 500 milliliter, give to add after preservative sodium benzoate 2.5 grams stir potting in the medicinal liquid, the mattress that goes out promptly gets oral liquid of the present invention half an hour.
Claims (1)
1, a kind of oral liquid that is used to alleviate pain among cancer patients is characterized in that, prescription and production technology are as follows:
(1) take by weighing Chinese herbal medicine: a of Rhizoma Chuanxiong (30--35 gram) doubly measures, the a of Radix Angelicae Sinensis (35--40 gram) doubly measures, a of Rhizoma Zingiberis Recens (2--5 gram) doubly measures, a of Radix Aconiti Kusnezoffii (5--15 gram) doubly measures, a of Radix Glycyrrhizae (3--8 gram) doubly measures, a of Radix Salviae Miltiorrhizae (10--20 gram) doubly measures, a of Flos Daturae (5--15 gram) doubly measures
(2) with the Rhizoma Chuanxiong that takes by weighing, Radix Angelicae Sinensis, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Radix Aconiti Kusnezoffii, Radix Salviae Miltiorrhizae chopping, add its weight 8--12 cold water doubly, soaked after 20-40 minute decoction 20-40 minute,
(3) give the Flos Daturae that adding takes by weighing in the medicinal liquid, continue to decoct 40--80 minute, separating liquid medicine is gone out, it is the medicinal liquid I,
(4) give the water that adds 6--10 times of spice gross weight in the isolated medicinal residues, continue to decoct 40--80 minute, separating liquid medicine is gone out again, it is the medicinal liquid II,
(5) again with adding 4--8 times water of spice total amount in the isolated medicinal residues in (4) and decocting 50--70 minute, separating liquid medicine is gone out, it is the medicinal liquid III again,
(6) three isolated medicinal liquid I, II, III are merged filtration, filtrate decompression is condensed into cream, after the cooling, 95% ethanol that the 2--4 of adding extractum doubly measures makes precipitation, leaves standstill 20--28 hour again, and get supernatant and reclaim ethanol to the extractum shape,
(7) the extractum adding distil water is an amount of, make every milliliter of medicinal liquid contain crude drug 1.5--2.5 gram, and a that adds preservative sodium benzoate (0.2--0.4 gram) doubly measure through stirring, potting, sterilizing promptly gets the alleged oral liquid of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96118736 CN1063056C (en) | 1996-07-18 | 1996-07-18 | Oral liquid for relieving pain of cancer patient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96118736 CN1063056C (en) | 1996-07-18 | 1996-07-18 | Oral liquid for relieving pain of cancer patient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1146361A CN1146361A (en) | 1997-04-02 |
| CN1063056C true CN1063056C (en) | 2001-03-14 |
Family
ID=5125303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96118736 Expired - Fee Related CN1063056C (en) | 1996-07-18 | 1996-07-18 | Oral liquid for relieving pain of cancer patient |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063056C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090968C (en) * | 1999-11-16 | 2002-09-18 | 吉林省力源药业股份有限公司 | Chinese-medicinal analgesic and sedative and preparing process thereof |
-
1996
- 1996-07-18 CN CN 96118736 patent/CN1063056C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1146361A (en) | 1997-04-02 |
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