CN1158087C - Process for preparing 'Qianjin' capsule to treat ganopathy - Google Patents
Process for preparing 'Qianjin' capsule to treat ganopathy Download PDFInfo
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- CN1158087C CN1158087C CNB991156838A CN99115683A CN1158087C CN 1158087 C CN1158087 C CN 1158087C CN B991156838 A CNB991156838 A CN B991156838A CN 99115683 A CN99115683 A CN 99115683A CN 1158087 C CN1158087 C CN 1158087C
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- radix
- water
- filtrate
- clear paste
- capsule
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- Expired - Lifetime
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- 239000002775 capsule Substances 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 238000000034 method Methods 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000706 filtrate Substances 0.000 claims abstract description 14
- 241000746375 Andrographis Species 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 238000010992 reflux Methods 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims description 8
- 241000756943 Codonopsis Species 0.000 claims description 7
- 239000002893 slag Substances 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 241000125175 Angelica Species 0.000 abstract 3
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 3
- TYIYMOAHACZAMQ-CQSZACIVSA-N Cyhalofop-butyl Chemical compound C1=CC(O[C@H](C)C(=O)OCCCC)=CC=C1OC1=CC=C(C#N)C=C1F TYIYMOAHACZAMQ-CQSZACIVSA-N 0.000 abstract 2
- 241001278833 Rosa laevigata Species 0.000 abstract 2
- 235000000661 Rosa laevigata Nutrition 0.000 abstract 2
- 235000007650 Aralia spinosa Nutrition 0.000 abstract 1
- 241000949456 Zanthoxylum Species 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 235000015170 shellfish Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 21
- 239000003814 drug Substances 0.000 description 18
- 230000001684 chronic effect Effects 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000012567 medical material Substances 0.000 description 5
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 4
- 206010008323 cervicitis Diseases 0.000 description 4
- 201000003988 chronic cervicitis Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 241001147468 Chondrus ocellatus Species 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 206010014025 Ear swelling Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004145 Endometritis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 208000030373 chronic endometritis Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a gynecology cyhalofop butyl ester capsule which takes moghania, cherokee rose root, common andrographis herb, angelica, mahoniae, lignum millettiae and dangshen as raw materials. In the preparation method, firstly, the common andrographis herb and the angelica are extracted by ethanol in a heating reflux method, and concentrated into a paste; secondly, the mahoniae and the shellfish pricklyash root are boiled with water, extracted twice and concentrated into a paste; thirdly, the moghania, the cherokee rose root, the lignum millettiae and the dangshen are boiled with water, extracted and filtered, the filtration residues and the mixed dregs of the common andrographis herb and the angelica are twice boiled with water, and the two filtrates are merged and concentrated into a paste; and fourthly, the three pastes are merged, uniformly mixed, spray-dried, made into granules and filled, and the gynecology cyhalofop butyl ester capsule is obtained.
Description
The present invention relates to a kind of capsular manufacture method for the treatment of gynaecopathia, belong to Chinese medicinal capsule manufacturing process class.
China's Chinese medicine generally all adopts decoction, pill, powder etc.; Later on along with tablet has appearred again in society's science and technology, economic progress.FUKE QIANJIN PIAN is to be raw material with Chinese crude drug Radix Flemingiae Philippinensis, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Radix Rosae Laevigatae, Caulis Spatholobi and Radix Codonopsis, through the tablet form compound Chinese patent medicine of selecting materials, pulverizing, operation such as granulation, coating being made.Clinical practice through has for many years shown that it is a kind of a kind of cheap and good-quality good medicine that is applicable to gynaecopathias such as woman uterus inflammation, urgent chronic pelvic inflammatory disease, endometritis, menoxenia, leucorrhoea grow in quantity really.
The Chinese patent medicine FUKE QIANJIN PIAN is a kind of rare gynecological's good medicine, but it still exists some shortcomings of Chinese patent medicine tablet: dose is bigger, will eat 6 at every turn; Patient is when taking this tablet, though eaten into the active ingredient that it works the effect of curing the disease, the adjuvant of in fact also having eaten into fiber such as quite a few plant roots that contains these medicine active ingredients, stem, leaf and invalid element simultaneously and having added in production process.Patient is after taking medicine, and some active ingredient can not fully be digested and assimilated and excrete thereupon by the intestines and stomach; And patient is after taking medicine, and tablet disintegration time under one's belt is long, it is slow or the like to take effect.So how to improve the bioavailability of Chinese medicine, active ingredient is fully extracted, improving curative effect of medication is the developing direction of Chinese patent medicine, capsule then is one of its correct selection path.
Purpose of the present invention aims to provide the requirement of a kind of adaptation FUKE QIANJIN PIAN compatibility, can make the capsule manufacture method of its performance optimum curative effect.
This is the capsule of compatibility by Chinese crude drug Radix Flemingiae Philippinensis, Radix Rosae Laevigatae, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Caulis Spatholobi and Radix Codonopsis, and its manufacture method is:
The ethanol that A, the Radix Angelicae Sinensis one that at first will wear 9% Herba Andrographis and 9% are reinstated 85% concentration extracts through heating reflux method and filters, and reclaims ethanol, and filtrate is condensed into clear paste;
B, secondly be that Fructus Zanthoxyli Dissiti decocting in water with 16% Caulis Mahoniae and 9% extracts, filter and filtrate is condensed into clear paste after taking off slag;
C, the Radix Flemingiae Philippinensis with 16%, 16% Radix Rosae Laevigatae, 16% Caulis Spatholobi, 9% Radix Codonopsis decocting in water extract, filter and take off slag and get filtrate, and filtering residue and A operation gained Herba Andrographis, Radix Angelicae Sinensis filtering residue are merged, once more after the decocting in water extraction; The merging of twice gained filter rear filtrate is condensed into clear paste;
D, merge above-mentioned three kinds of clear paste through mixing, spray drying, granulation, fill four procedures finished capsule product.
The capsule of the treatment gynaecopathia of producing according to said method, compare with present FUKE QIANJIN PIAN, its advantage is the relative enrichment of active ingredient that makes in the medical material, improve content, eliminate former mix and be contained in the invalid thing in the Herba Andrographis and Radix Angelicae Sinensis in the FUKE QIANJIN PIAN, patient's drug administration amount is reduced, improve curative effect, instant effect.
Below provide embodiment, and further set forth the present invention in conjunction with the embodiments:
Prescription according to the compound women's QIANJIN PIAN: the incorporation of Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis and Fructus Zanthoxyli Dissiti respectively is 9% of a medical material gross weight; The incorporation of Radix Rosae Laevigatae, Caulis Spatholobi, Caulis Mahoniae and Radix Flemingiae Philippinensis respectively is 16% of a medical material total amount.
Then according to above-mentioned process, at first Herba Andrographis and Radix Angelicae Sinensis are extracted both active ingredients through heating reflux method with the ethanol of 85% concentration, filtration is taken off slag and is obtained the filtrate that ethanol is solvent later on, and concentrated filtrate obtains to contain the effect clear paste of curing the disease in Herba Andrographis and the Radix Angelicae Sinensis after reclaiming ethanol.
Secondly respectively with Caulis Mahoniae, Fructus Zanthoxyli Dissiti, and Radix Flemingiae Philippinensis, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water respectively, take off slag and obtain corresponding filtrate through extracting, filtering; Wherein the filtrate of Caulis Mahoniae and Fructus Zanthoxyli Dissiti directly is condensed into clear paste.And carry again staying behind Radix Flemingiae Philippinensis, Radix Rosae Laevigatae, Caulis Spatholobi, the Radix Codonopsis decocting in water; With concentrated the third clear paste of making of this extracting solution and extracting solution merging for the first time.
The most above-mentioned three kinds of clear paste merge after the mixing, spray-dried, granulation, fill operation the capsule used of the alleged treatment gynaecopathia of the present invention.
In above-mentioned operation, what really play effect is that above-mentioned all medical materials are adopted the method for extracting of handling respectively; Experiment through this programme inventor: adopt the difference decocting in water extracting method of Radix Rosae Laevigatae, Radix Flemingiae Philippinensis and Caulis Mahoniae and Fructus Zanthoxyli Dissiti, extract than decocting in water that above-mentioned four kinds of medical materials are mixed, the content of tannin and berberine exceeds 2.5～5 times respectively in its filtrate.
The result shows through zoopery: this gynecological's capsule all has the obvious suppression effect to rat paw edema due to Oleum Tiglii induced mice ear swelling, the chondrus ocellatus Holmes and rat cotton balls granuloma.The rat uterus inflammation is also had good inhibitory action, and the effect of capsule sheet is better than tablet.Gynecological's capsule can resist the capillary permeability increase effect of acetic acid induced mice abdominal cavity, and the type blood deficiency mice that loses blood is had tangible blood tonification effect, can also resist the immune function of mice reduction that cyclophosphamide causes.Extracorporeal bacteria inhibitor test is the result show: to 9 kinds of antibacterials such as escherichia coli the clinical separation of totally 95 strains cause bacterium and have certain bacteriostasis.To the coli-infection mice, high dose has the certain protection effect, and the capsule effect slightly is better than tablet.
The clinical observe the curative effect of starting is as follows:
Through No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College, Hunan Province woman keep healthy institute, Hunan Province Affiliated Hospital of the academy of traditional Chinese medicine from March, 1998～1998 year November to 381 routine women's chronic pelvic inflammatory diseases, chronic endometritis, chronic cervicitis patient, the three kinds of medicines of capsule, JINJI PIAN that adopt FUKE QIANJIN PIAN, the inventive method to produce are treated, test group (Capsules group) 161 examples wherein, matched group (FUKE QIANJIN PIAN group) 100 examples; Chronic palace intimitis 60 examples, wherein each 30 example of test group (Capsules group) and matched group (FUKE QIANJIN PIAN group); Chronic cervicitis 60 examples, wherein each 30 example of test group (Capsules group) and matched group (FUKE QIANJIN PIAN group).And with state of an illness integrated value judgement curative effect before and after the treatment.
The result shows: the total obvious effective rate of (1) capsule for treating chronic pelvic inflammatory disease, total effective rate are respectively 80.12%, 98.75%; Treat the total obvious effective rate of chronic palace intimitis, total effective rate is respectively 100%, 100%; The total obvious effective rate of treatment chronic cervicitis, total effective rate are respectively 33.3%, 96.7%; Its determined curative effect is better than FUKE QIANJIN PIAN sheet group; The medicine of (2) two kinds of dosage forms all has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, benefiting qi and nourishing blood, strong waist and nourishing kidney, and chronic pelvic inflammatory disease, chronic palace intimitis, chronic cervicitis patient are all had better curative effect.(3) capsule lacks than the QIANJIN PIAN consumption, and it is more convenient to take medicine, and welcome by patient and clinician; (4) capsule administration safety is not seen toxic and side effects and untoward reaction in the observation process.
Clinical application shows: FUKE QIANJIN PIAN and capsule curative effect obviously are better than JINJI PIAN, and the capsule curative effect is better than FUKE QIANJIN PIAN.Really reach final goal of the present invention.
Claims (1)
1, a kind of capsular manufacture method for the treatment of gynaecopathia is characterized in that it is by following weight percentages, makes by following technology:
A, the ethanol of at first Radix Angelicae Sinensis one of 9% Herba Andrographis and 9% being reinstated 85% concentration extract through heating reflux method and filter, and reclaim ethanol, and filtrate is condensed into clear paste;
B, secondly be that Fructus Zanthoxyli Dissiti decocting in water with 16% Caulis Mahoniae and 9% extracts, filter and filtrate is condensed into clear paste after taking off slag;
C, the Radix Flemingiae Philippinensis with 16%, 16% Radix Rosae Laevigatae, 16% Caulis Spatholobi and 9% Radix Codonopsis decocting in water extract, filtration is taken off slag and is got filtrate, and the filtering residue of filtering residue and A operation gained Herba Andrographis and Radix Angelicae Sinensis is merged, after decocting in water extracts once more, twice gained filter rear filtrate merged, and be condensed into clear paste;
D, merge above-mentioned three kinds of clear paste, through mixing, spray drying, granulation, fill four procedures finished capsule product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991156838A CN1158087C (en) | 1999-12-07 | 1999-12-07 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991156838A CN1158087C (en) | 1999-12-07 | 1999-12-07 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1298731A CN1298731A (en) | 2001-06-13 |
| CN1158087C true CN1158087C (en) | 2004-07-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB991156838A Expired - Lifetime CN1158087C (en) | 1999-12-07 | 1999-12-07 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1158087C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10329316B2 (en) | 2016-03-17 | 2019-06-25 | Qianjin Pharmaceutical Co., Ltd. | Phenylpropanoid compound and preparation method and use thereof |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296071C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1321631C (en) * | 2004-06-18 | 2007-06-20 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1296072C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1296073C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1330335C (en) * | 2004-06-18 | 2007-08-08 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1318054C (en) * | 2004-08-26 | 2007-05-30 | 仁和（集团）发展有限公司 | Prepn process of medicine for treating gynecopathy |
| CN1310639C (en) * | 2004-11-25 | 2007-04-18 | 张平 | Effervescence tablet for treating gynecopathy and preparation method thereof |
| CN1318055C (en) * | 2004-12-03 | 2007-05-30 | 仁和（集团）发展有限公司 | Method for preparing medicine |
| CN106650197B (en) * | 2016-08-12 | 2019-09-20 | 株洲千金药业股份有限公司 | Chinese and Western is combined drug PPK-PPD method for establishing model and gynaecology's prescriptions worth thousand gold composition and azithromycin combination evaluation application |
| CN107080817B (en) * | 2017-05-04 | 2020-05-12 | 上海市静安区芷江西路街道社区卫生服务中心 | Novel gynecological Qianjin zedoary turmeric oil suppository |
-
1999
- 1999-12-07 CN CNB991156838A patent/CN1158087C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10329316B2 (en) | 2016-03-17 | 2019-06-25 | Qianjin Pharmaceutical Co., Ltd. | Phenylpropanoid compound and preparation method and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1298731A (en) | 2001-06-13 |
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