CN1296072C - Method for preparing a gynecopathy treating medicine - Google Patents
Method for preparing a gynecopathy treating medicine Download PDFInfo
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- CN1296072C CN1296072C CNB2004100233192A CN200410023319A CN1296072C CN 1296072 C CN1296072 C CN 1296072C CN B2004100233192 A CNB2004100233192 A CN B2004100233192A CN 200410023319 A CN200410023319 A CN 200410023319A CN 1296072 C CN1296072 C CN 1296072C
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Abstract
The present invention relates to a preparation method of a medicine for treating gynecopathy. The medicine is prepared from dangshen, Zanthoxylum dissitum Hemsl, mahonia stem, cherokee rose root, radix moghania, leatherleaf milletia, angelica and creat. The preparation method comprises the steps that the angelica is extracted and filtered by ethanol with a heating reflux method or a percolation method; after the ethanol is recovered, the filtered angelica is concentrated into extract; medical dregs are reserved for standby. The dangshen, the Zanthoxylum dissitum Hemsl, the mahonia stem, the cherokee rose root, the radix moghania and the leatherleaf milletia are put in an extractor to be extracted with water for the first time; then, filtered dregs and angelica dregs are merged to be boiled and extracted with water for the second time and then are filtered; filtered liquids are merged and are concentrated into spare extract whose specific weight is 1.08/80 DEG C. the creat is pulverized into a mixed powdery material giving priority to micron and nanometer granules; the creat powdery material is uniformly mixed with the extract to be granulated, dried and pressed into a tablet patent medicine or a capsule patent medicine by filling. The present invention enhances bioavailability, enhances medical therapeutic effect, decreases dosage and improves working environment.
Description
Technical field
The present invention relates to a kind of process for preparing medicine for the treatment of gynaecopathia, referring in particular to Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis is the manufacture method of gynecological's Chinese patent medicine of raw material.
Background technology
The patent No. is a kind of claimed manufacturing technique method that ZL98112696.0's " a kind of process for preparing medicine for the treatment of gynaecopathia " " FUKE QIANJIN PIAN " that to be the applicant produce for company at that time on October 21st, 1998 proposes.In above-mentioned disclosed production method, its protection fundamentally mainly embodies a concentrated reflection of both ways: the first is ground into fine powder more than 100 orders with Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis three flavor Chinese crude drugs in pulverizer, leaves and takes 93.3% standby; It two is that Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis and the Caulis Spatholobi Chinese medicine of the five flavours that will choose is placed in the extraction pot together, adds hot water and extracts twice by the method for extracting once in per 2 hours, crosses leaching liquid; Then extracting solution is condensed into proportion and is 10.8/80 ℃ extractum in concentrator.
Then, my company has proposed medicine---the FUKE QIANJIN PIAN with the treatment gynaecopathia again, production method with two kinds of capsules of identical prescription, and submitted the patent application (patent No. and application number are respectively: 99115682.x, 99115683.8) of two kinds of capsule manufacture methods on the 7th in December in 1999 to State Patent Office.
In the manufacture method of these two kinds of capsules, its main characteristics is: Radix Angelicae Sinensis and this two flavors Chinese medicine of Herba Andrographis are extracted both effective ingredient with alcohol heating reflux method or alcohol percolation method together or respectively, to reach the content that both reduces fecula material in the patent medicine, improve the amount of effective ingredient again, thereby make the patient both reduce dosage, can keep good efficacy again.
Though production practices for many years show above-mentioned kinds of processes method and are successfully effective in the production of instructing " FUKE QIANJIN PIAN ".But along with deep development to pharmaceutics of Chinese drugs and Chinese crude drug pharmacological research, especially in today of other subject technology develop rapidly, be based upon the production method of " FUKE QIANJIN PIAN " series of products on traditional Chinese patent medicine manufacturing technique method, the demand of incompatibility development of the situation.Therefore, how to guarantee under the product quality prerequisite, further reduce production costs, medicament curative effect enhancement, the preparation method of the medicine of more effective, more economical treatment gynaecopathia is provided for society and patient, from production technology, innovate, become the producer of this product of production and scientific research personnel's a main direction.
Technology contents
Purpose of the present invention: be intended on the basis of forefathers to " FUKE QIANJIN PIAN " series of products and technical study, under the prerequisite that does not change its basic prescription compatibility, a kind of more scientific and rational process for preparing medicine that can treat gynaecopathia is proposed, wish that it can not only continue to keep good drug effect, also can further improve simultaneously the utilization rate of Chinese material medicine resource, thereby bring better economic benefit and social benefit for manufacturer.
The preparation method of the medicine of this treatment gynaecopathia, it is made by Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Herba Andrographis, it is characterized in that preparing as follows:
A, the Chinese crude drug 9 weight portion Radix Angelicae Sinensis chosen are extracted with alcohol heat reflux method or alcohol percolation method filter, through reclaiming ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum, and medicinal residues are standby;
B, the 9 weight portion Radix Codonopsis that will choose, 9 weight portion Fructus Zanthoxyli Dissiti, 16 weight portion Caulis Mahoniaes, 16 weight portion Radix Rosae Laevigataes, 16 weight portion Radix Flemingiae Philippinensiss, 16 weight portion Caulis Spatholobi Six-element Chinese crude drugs are put together and are placed extractor, and decocting in water extracted once in 2 hours, crossed leaching liquid; And the extraction again after 2 hours with this filtering residue and A operation Radix Angelicae Sinensis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate; Twice gained filter rear filtrate is merged, and to be condensed into proportion be 1.08/80 ℃ standby extractum;
C, will in pulverizer, be ground into by the 9 weight portion Herba Andrographis that prescription is chosen based on the micron order of 0.1-1.0 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
The extractum mixing that D, the Herba Andrographis powder that will obtain from C technology and two technologies of A, B are obtained is respectively granulated later on, and drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
Described Fructus Zanthoxyli Dissiti, Caulis Mahoniae two flavor Chinese crude drugs and Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs separate the decocting in water extraction, and obtain standby extractum; And the independent decocting in water of Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs was extracted once in 2 hours, cross leaching liquid; And the Radix Angelicae Sinensis medicinal residues in this filtering residue and the A operation are merged decocting in water and extract again after 2 hours, filter and take off slag and get filtrate, be 1.08/80 ℃ standby extractum with being condensed into proportion for twice the merging of gained filtrate.
Described Herba Andrographis mixed powder is to be the fine powder of 10～150 μ m based on particle diameter.
Described Herba Andrographis mixed powder is to be the fine powder of 0.1～10 μ m based on particle diameter.
Described Herba Andrographis mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
Described Herba Andrographis mixed powder is made up of two kinds of powders in fine powder, micropowder, three kinds of granules of nano powder at least.
A kind of preparation method for the treatment of medicine for gynecopathy according to above technical scheme proposition, obtained comparing of patent of invention with our company with the production method, its main feature is: the one, Radix Codonopsis is extracted by pulverizing starch, change into to incorporate into Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Flemingiae Philippinensis, Radix Rosae Laevigatae, Caulis Spatholobi decocting in water; So both reduce the starch amount, dose is reduced, also alleviated dust pollution in the production simultaneously; The more important thing is the extraction that helps the Radix Codonopsis water soluble ingredient; The 2nd, Herba Andrographis is used as medicine with micron order and nano level superfine powder, both made the easier stripping of effective ingredient in the medical material, also be beneficial to absorption of human body, improve bioavailability.
The specific embodiment
Improve the preparation method of the medicine (FUKE QIANJIN PIAN) of later treatment gynaecopathia according to this innovation of technique scheme proposition, its prescription is still continued to use the main formula compatibility of ZL98112696.0 patent, and promptly this medicine-FUKE QIANJIN PIAN is still by respectively being Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis, the Fructus Zanthoxyli Dissiti of 9 weight portions and respectively being Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the common prescription of Caulis Spatholobi eight flavor Chinese crude drugs of 16 weight portions.
Concrete preparation method is as follows:
A, the Chinese crude drug Radix Angelicae Sinensis chosen extracted with alcohol heat reflux method or alcohol percolation method filter, through reclaiming ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum, and medicinal residues are standby;
B, Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae with choosing, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi Six-element Chinese crude drug are put together and are placed extractor, and decocting in water extracted once in 2 hours, crossed leaching liquid; And the extraction again after 2 hours with this filtering residue and A operation Radix Angelicae Sinensis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate; Twice gained filter rear filtrate is merged, and to be condensed into proportion be 1.08/80 ℃ standby extractum;
C, will in pulverizer, be ground into by the Herba Andrographis that prescription is chosen based on the micron order of 0.1-1.0 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
The extractum mixing that D, the Herba Andrographis powder that will obtain from C technology and two technologies of A, B are obtained is respectively granulated later on, and drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
Described Fructus Zanthoxyli Dissiti, Caulis Mahoniae two flavor Chinese crude drugs and Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs separate the decocting in water extraction, and obtain standby extractum; And the independent decocting in water of Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs was extracted once in 2 hours, cross leaching liquid; And the Radix Angelicae Sinensis medicinal residues in this filtering residue and the A operation are merged decocting in water and extract again after 2 hours, filter and take off slag and get filtrate, be 1.08/80 ℃ standby extractum with being condensed into proportion for twice the merging of gained filtrate.
Described Herba Andrographis mixed powder is to be the fine powder of 10～150 μ m based on particle diameter.
Described Herba Andrographis mixed powder is to be the fine powder of 0.1～10 μ m based on particle diameter.
Described Herba Andrographis mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
Described Herba Andrographis mixed powder is made up of two kinds of powders in fine powder, micropowder, three kinds of granules of nano powder at least.
Why the scientific research personnel of our company proposes once more for this innovation and the improvement that is used for the treatment of the medicine for gynecopathy production technology of FUKE QIANJIN PIAN, mainly based on two big reasons:
The one, along with the appearance of nanometer theory, herbal pharmaceutical is to being in the research of dependency relation between nanoscale, micron order drug particles and the drug effect;
The 2nd, this seminar person of having utilize the current paper data to this flavor Chinese medicine Chinese crude drug of Radix Codonopsis re-recognizing aspect the pharmacological properties.
Micron Chinese medicine and nanometer Chinese medicine are meant that adopting the modern high technology nanotechnology to combine with the process of preparing Chinese medicine of Chinese medicine tradition and preparation technique develops; can keep Chinese medicine to have pharmacodynamics material base, granularity to be respectively 0.1～10 μ m micron particles or particle diameter new medicine less than 0.1 μ m nano-scale particle.
Modern medicine is all thought material base that Chinese medicine prevents and cures diseases from biological activity position or active chemical components, and therefore, general traditional medicine scholar's attention mainly concentrates on to seek to be had on the various bioactive chemical compounds.But through the modern science personnel traditional Chinese medical science, Chinese medicine further investigation are shown: living organism is an extremely complex physical chemical process to absorption, metabolism, the drainage of medicine, the pharmacodynamics effect that Chinese medicine produces can not give the credit to the distinctive chemical composition of this medicine uniquely, and is also closely related with the physical state of medicine etc.Therefore, changing the physical state of medicine, is the raising drug effect, also is a kind of method that is worth trying to explore of development newtype drug.
From having had many scientific and technical personnel some Chinese crude drug to be changed the test of drug unit size (volume) the disclosed documents and materials at present, result of the test shows, use distinct methods, can change primary crude drug, make it to make the granularity difference, the biological activity of its medicine and availability all can be largely increased.Its reason is: the dissolution rate of medicine is directly proportional with the specific grain surface of medicine is long-pending, and this surface area and particle diameter are inversely proportional to.Therefore, the particle diameter of medicine is thin more, and its surface area is big more, helps the stripping of effective ingredient more.
Just be based on above-mentioned theory research and document foundation, medicine---the prescription characteristics of FUKE QIANJIN PIAN of the scientific research personnel of this seminar binding energy treatment gynaecopathia, the Chinese medicine Herba Andrographis of powder is worn in proposition to the flavor of two in the raw material, processing particle diameter in flour mill proposes following requirement, and promptly the powder of 0.1-10 μ m and the particle diameter below the 0.1 μ m should account for more than 80% in fine powder after grinding and the fine powder.The result who so does not only makes degradation rate bring up to more than 95% from 93.3, has improved the medical material utilization rate; Also will improve the raising that brings drug action for the dissolution of active substance in using.
In addition, why research worker of the present invention proposes: Radix Codonopsis is carried out decocting in water with Fructus Zanthoxyli Dissiti, Caulis Mahoniae, this five tastes medical material of Radix Flemingiae Philippinensis and Caulis Spatholobi extract, its reason has three:
One adopts methods such as water extraction, solvent extraction that Radix Codonopsis is carried out chemical analysis and studies show that Radix Codonopsis mainly contains polysaccharide according to relevant scholar, multiple tangshenoside, n-hexyl-β-D glycoside, α-D-fructose ethanol glycoside etc.; Sterols composition such as α-Bo sterol, stigmasterol etc., its main pharmacodynamics material is water-soluble components, extracts by decocting in water, can the main pharmacodynamics composition of Radix Codonopsis be extracted comparatively fully.Changing Radix Codonopsis into decocting in water from original grinding extracts, this is more to give full play to better, the more effective processing method that Radix Codonopsis acts in this treatment medicine for gynecopathy of FUKE QIANJIN PIAN, also is the technical foundation of further this prescription being carried out evaluation of pharmacology prescription and clinical evaluation.
Its two, it is the one of the main reasons that causes the FUKE QIANJIN PIAN dose excessive that FUKE QIANJIN PIAN dose excessive (three times on the one, a time 6) Radix Codonopsis is pulverized with starch, can reduce the starch amount after changing decocting in water into, and dose is reduced.
Its three, at the pulverization process of existing FUKE QIANJIN PIAN production technology to Radix Codonopsis, existing Radix Codonopsis is pulverized processing method, must first Radix Codonopsis be wanted the drying operation; Changing decocting in water into can shorten processing link later on, reduce production costs; And out-of-date methods also have a defective in processing is pulverized, and dust is too big in the crushing process, and is unfavorable to environmental conservation, and after changing decocting in water into and extracting, working environment are improved.
For the be used as medicine change of processing method of Radix Angelicae Sinensis, its purpose has three: reduce starch and both can reduce taking dose, improve bioavailability; Reduce being used as medicine of fecula simultaneously, reduced the dose of patent medicine, can deduct the dust in the Radix Angelicae Sinensis processing, obviously improved working environment; With the decocting in water extraction once more of Radix Angelicae Sinensis recrement, the aqueous soluble active constituent in the Radix Angelicae Sinensis is also fully extracted, medical material is fully fully utilized.
In addition, why research worker of the present invention proposes that Fructus Zanthoxyli Dissiti, Caulis Mahoniae are separated decocting in water with Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi is extracted, and this is based on our the deep progress to the research and the test of prescription medicine galenic pharmacy.This five kinds of Chinese medicine, especially the first four traditional Chinese medicine in this prescription, their pharmacological action is: contain alkaloid-berberine hydrochloride in Caulis Mahoniae and the Fructus Zanthoxyli Dissiti, contain tannin in Radix Rosae Laevigatae and the Radix Flemingiae Philippinensis.Therefore, what of the berberine hydrochloride that extracts in these four kinds of medical materials, content of tannin not only can play an important role to drug effect, and to produce prescription all significant to further adjusting later on.
Testing program and result are as follows:
One group: Radix Rosae Laevigatae 150 grams, Radix Flemingiae Philippinensis 150 grams.
Two groups: Caulis Mahoniae 150 grams, Fructus Zanthoxyli Dissiti 84.4 grams.
Three groups: Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, each 150 gram of Caulis Mahoniae, Fructus Zanthoxyli Dissiti 84.4 grams.
Experimental implementation: the medical material of specified in packets is pressed into fragment, places 3 to boil and carry container respectively, add 6 times of decoctings and boil 2 times to the medical material amount, each 2 hours, filter, filtrate is condensed into dried cream and accurate the title quantitatively respectively, 3 parts of dried cream samples.
Keep sample: 3 parts of dried cream samples are also indicated accurate weight, and are standby.
Sample is denoted as: 3-1,3-2,3-3 (totally 3 increments).
Measure: the content of tannin in one group, the content of berberine hydrochloride in two groups, the content of tannin and berberine hydrochloride in three groups.The data rows following table:
Compatibility changes the test data table
| Label | Dried cream heavy (g) | Tannin | Berberine hydrochloride | Content of tannin | Content of berberine hydrochloride |
| 3-1 | 28.4612 | 23.60％ | / | 6.7168g | / |
| 3-2 | 9.5329 | / | 4.0475mg/g | / | 0.3858mg |
| 3-3 | 33.7912 | 9.800％ | 0.7845mg/g | 3.3115g | 0.2651mg |
Test shows: after the medical material of Radix Rosae Laevigatae, Radix Flemingiae Philippinensis (containing the tannin composition) and Caulis Mahoniae, Fructus Zanthoxyli Dissiti (containing alkaloid) adopts and separate and merges decoction and test, with Radix Rosae Laevigatae and Radix Flemingiae Philippinensis and Caulis Mahoniae, Fructus Zanthoxyli Dissiti separate boil separately get after, the content of its working substance tannin has increased by one times with respect to old merging decocting method; Equally, separately boil the berberine hydrochloride that from Caulis Mahoniae and Fructus Zanthoxyli Dissiti, obtains after getting and also increase by 45.5%.This result fully shows: this two classes medical material is unwell to close to be fried in shallow oil, and should separately decoct.
Claims (6)
1, a kind of preparation method for the treatment of the medicine of gynaecopathia, it is made by Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Herba Andrographis, it is characterized in that preparing as follows:
A, the Chinese crude drug 9 weight portion Radix Angelicae Sinensis chosen are extracted with alcohol heat reflux method or alcohol percolation method filter, through reclaiming ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum, and medicinal residues are standby;
B, the 9 weight portion Radix Codonopsis that will choose, 9 weight portion Fructus Zanthoxyli Dissiti, 16 weight portion Caulis Mahoniaes, 16 weight portion Radix Rosae Laevigataes, 16 weight portion Radix Flemingiae Philippinensiss, 16 weight portion Caulis Spatholobi Six-element Chinese crude drugs are put together and are placed extractor, and decocting in water extracted once in 2 hours, crossed leaching liquid; And the extraction again after 2 hours with this filtering residue and A operation Radix Angelicae Sinensis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate; Twice gained filter rear filtrate is merged, and to be condensed into proportion be 1.08/80 ℃ standby extractum;
C, will in pulverizer, be ground into by the 9 weight portion Herba Andrographis that prescription is chosen based on the micron order of 0.1-1.0 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
The extractum mixing that D, the Herba Andrographis powder that will obtain from C technology and two technologies of A, B are obtained is respectively granulated later on, and drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
2, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1, it is characterized in that: described Fructus Zanthoxyli Dissiti, Caulis Mahoniae two flavor Chinese crude drugs and Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs separate the decocting in water extraction, and obtain standby extractum; And the independent decocting in water of Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs was extracted once in 2 hours, cross leaching liquid; And the Radix Angelicae Sinensis medicinal residues in this filtering residue and the A operation are merged decocting in water and extract again after 2 hours, filter and take off slag and get filtrate, be 1.08/80 ℃ standby extractum with being condensed into proportion for twice the merging of gained filtrate.
3, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Herba Andrographis mixed powder is to be the fine powder of 10～150 μ m based on particle diameter.
4, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Herba Andrographis mixed powder is to be the fine powder of 0.1～10 μ m based on particle diameter.
5, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Herba Andrographis mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
6, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Herba Andrographis mixed powder is made up of two kinds of powders in fine powder, micropowder, three kinds of granules of nano powder at least.
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| CNB2004100233192A CN1296072C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
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| CNB2004100233192A CN1296072C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925364A (en) * | 2017-12-17 | 2019-06-25 | 株洲千金药业股份有限公司 | A kind of Chinese recipe for treating tinea pedis |
| US10329316B2 (en) | 2016-03-17 | 2019-06-25 | Qianjin Pharmaceutical Co., Ltd. | Phenylpropanoid compound and preparation method and use thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318055C (en) * | 2004-12-03 | 2007-05-30 | 仁和（集团）发展有限公司 | Method for preparing medicine |
| CN109718296A (en) * | 2017-10-31 | 2019-05-07 | 株洲千金药业股份有限公司 | A kind of warm nest patch of analgesic antiphlogistic |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298731A (en) * | 1999-12-07 | 2001-06-13 | 株洲千金药业股份有限公司 | Process for preparing 'Qianjin' capsule to treat ganopathy |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1298731A (en) * | 1999-12-07 | 2001-06-13 | 株洲千金药业股份有限公司 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10329316B2 (en) | 2016-03-17 | 2019-06-25 | Qianjin Pharmaceutical Co., Ltd. | Phenylpropanoid compound and preparation method and use thereof |
| CN109925364A (en) * | 2017-12-17 | 2019-06-25 | 株洲千金药业股份有限公司 | A kind of Chinese recipe for treating tinea pedis |
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