CN1170578A - Earthworm capsule - Google Patents
Earthworm capsule Download PDFInfo
- Publication number
- CN1170578A CN1170578A CN96118724A CN96118724A CN1170578A CN 1170578 A CN1170578 A CN 1170578A CN 96118724 A CN96118724 A CN 96118724A CN 96118724 A CN96118724 A CN 96118724A CN 1170578 A CN1170578 A CN 1170578A
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- Prior art keywords
- percent
- earthworm
- esophageal cancer
- homogenate
- freezing
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- Pending
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- 239000002775 capsule Substances 0.000 title claims abstract description 10
- 241000361919 Metaphire sieboldi Species 0.000 title claims abstract description 8
- 238000007710 freezing Methods 0.000 claims abstract description 5
- 230000008014 freezing Effects 0.000 claims abstract description 5
- 238000004108 freeze drying Methods 0.000 claims abstract description 4
- 238000010257 thawing Methods 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 241000237636 Pheretima Species 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 238000005360 mashing Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000000859 sublimation Methods 0.000 claims description 3
- 230000008022 sublimation Effects 0.000 claims description 3
- 241000243684 Lumbricus Species 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 239000003643 water by type Substances 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 4
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract description 4
- 238000001959 radiotherapy Methods 0.000 abstract description 4
- 239000013543 active substance Substances 0.000 abstract description 3
- 230000001093 anti-cancer Effects 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 2
- 229930003268 Vitamin C Natural products 0.000 abstract description 2
- 235000001014 amino acid Nutrition 0.000 abstract description 2
- 229940024606 amino acid Drugs 0.000 abstract description 2
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 238000002512 chemotherapy Methods 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 235000019192 riboflavin Nutrition 0.000 abstract description 2
- 229960002477 riboflavin Drugs 0.000 abstract description 2
- 239000002151 riboflavin Substances 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 231100000820 toxicity test Toxicity 0.000 abstract description 2
- 239000011573 trace mineral Substances 0.000 abstract description 2
- 235000013619 trace mineral Nutrition 0.000 abstract description 2
- 235000019154 vitamin C Nutrition 0.000 abstract description 2
- 239000011718 vitamin C Substances 0.000 abstract description 2
- 201000004101 esophageal cancer Diseases 0.000 abstract 3
- 241001233061 earthworms Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 201000005619 esophageal carcinoma Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 241000237903 Hirudo Species 0.000 description 1
- 241000255626 Tabanus <genus> Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Earthworm capsule relates to an active substance-containing active substance product with anticancer function, which is prepared by washing fresh live earthworms with water, homogenating, freezing, thawing, filtering, freeze-drying and encapsulating. According to the determination, the earthworm capsule contains protein, a plurality of amino acids, riboflavin, vitamin C, DNA, RNA, reducing sugar, trace elements and the like. Toxicity tests prove that the Chinese medicinal composition has no toxic or side effect. Through clinical observation, the partial remission rate of 625 cases of late-stage esophageal cancer is 45 percent, the complete remission rate of the advanced-stage esophageal cancer combined with radiotherapy is 33 percent, the curative effect is obvious, and the effective rate of inhibiting lung cancer is 79.2 percent when the advanced-stage esophageal cancer combined with chemotherapy has obvious synergistic effect.
Description
The present invention relates to a kind of pharmaceutical products that contains anti-cancer active matter.
The traditional Chinese medical science thinks that the formation of tumor at first is positive QI-insufficiency, and it is poly-that zang-fu disharmony and cause qi depression to blood stasis, expectorant coagulate poison, and scorchingly hot penting up forms lump, name day " cancer ", " rock ".Though Chinese traditional treatment tumor rule is many, conclude not outer four big rules: method of dissipating heat and detoxifying, hard masses softening and resolving method, activating blood and removing stasis Method and the body resistance strengthening and constitution consolidating method.By blood removing blood stasis with potent drugs soup " the bright experience collection that borders in the south of Zhao " is one of famous anticancer prescription of blood-activating stasis-removing kind.
Form by Hirudo, worm, Pheretima, Semen Pharbitidis, Fructus Liquidambaris, Herba speranskiae tuberculatae, Fructus Polygoni Orientalis, Radix seu Herba Spiranthis Lanceae, Radix Arnebiae (Radix Lithospermi), Tabanus ten flavor Chinese medicines by blood removing blood stasis with potent drugs soup.
The Japan scholar helps the paper that the clear Yan Shi of rattan delivers at him: Chinese prescription research, 1979.2P51 described in: when the research Chinese medicine medicine for preventing, find, Pheretima through decoct, filtration, distilling under reduced pressure and the dry mixture that forms, be 50% to 70% to the suppression ratio of S180 transplanted tumor.
Also propose Pheretima in " clinical efficacy of Chinese medicine medicine for preventing " book of Qian Baiwen work and can be used for treating intracranial tumour (see Qian Baiwen: the clinical efficacy of Chinese medicine medicine for preventing, 113, Shanghai, Shanghai translation issuing company, 1986.1).
Lumbricus is referred to as Pheretima at Chinese medicine, therefore generally not containing poisonous composition, study on its antitumaous effect basis Pheretima as anticancer drug of first choice forefathers, is prerequisite not destroy its active substance, designed the extracting method of working substance, prepared PTS---earthworm capsule.
The objective of the invention is on the basis of forefathers research, go out pure Chinese medicine cancer therapy drug---earthworm capsule with the prepared of uniqueness.This Pheretima capsule contains protein, several amino acids, riboflavin, vitamin C, DNA and RNA, reducing sugar and trace element etc. after measured.Have no side effect through the toxicity test proof.Part remission rate through clinical observation 625 routine late esophagus cancers is 45%; Share with chemotherapeutic, the effective percentage 79.2% that suppresses pulmonary carcinoma has remarkable potentiation; With radiotherapy and usefulness, be 33% to the complete remission rate of the pulmonary carcinoma and the esophageal carcinoma, remarkable potentiation is arranged; With radiotherapy and usefulness, be 33% to the complete remission rate of the pulmonary carcinoma and the esophageal carcinoma, the notable synergistic effect is arranged.
The object of the present invention is achieved like this: earthworm capsule, get raw material Pheretima alive, wash, add water homogenate, freezing 48 hours, melt filtration, lyophilization incapsulates promptly, its detailed process is: new fresh and alive Pheretima, and tap water is cleaned, airing, 3 times of adding distil waters (W/W), with twice of high-speed tissue mashing machine's (800-12000 rev/min) homogenate, each 2 minutes, 20 seconds at interval, homogenate was put in the cryogenic refrigerator (below 20 ℃) freezing 48 hours, through freeze thawing (＜36 ℃), centrifugal 3000 rev/mins) 20 minutes, filter by (the quick filter paper of two-layer Xinhua), the cool lyophilizing of filtrate dry (pre-cooling-40 ℃, vacuum 10
2, 33 ℃ of sublimation temperatures, moisture content is lower than 70%) the one-tenth brown powder.
Accompanying drawing is preparation technology's flow chart of the present invention.
Advantage of the present invention is: have promoting blood circulation and removing blood stasis, clearing heat and detoxicating, dispersing swelling and dissipating binds, raising is thin Born of the same parents' immunologic function, inhibition tumor cell generates. Be used for the treatment of especially tumor in digestive tract effect of tumour Significantly, also can be used as the synergist effect of radiotherapy, chemotherapy.
Below in conjunction with embodiment in detail the present invention is described in detail:
Get the dark different lip earthworm 1000g of the back of the body, wash, add water 3000ml, homogenate is twice in high-speed tissue mashing machine, each 2 minutes, be crushed to more than the 10um (diameter) for the first time, be crushed to 3-10um (diameter) for the second time, put then below-20 ℃ and freeze 48hr, room temperature is smashed quick thawing for 30 ℃, and centrifugal 3000 change, and filter and abandon precipitate and suspension larger particles, frozen drying becomes brown powder (pre-cooling-40 ℃, vacuum 10
2, sublimation temperature＜33 ℃, moisture is lower than 7%).Divide encapsulated, cobalt 60
1,000,000Behind the rd irradiation-sterilize promptly.
Claims (2)
1. earthworm capsule is characterized in that getting the raw material Pheretima that lives, and washes, and adds water homogenate, freezing 48 hours, melts to filter, and lyophilization incapsulates promptly.
2. earthworm capsule according to claim 1 is characterized in that its preparation detailed process is: new fresh and alive Lumbricus, and tap water is cleaned airing, 3 times of adding distil waters (W/W), with high-speed tissue mashing machine's (8000-12000 rev/min) homogenate twice, each 2 minutes, 20 seconds at interval, homogenate was put in the cryogenic refrigerator (below 20 ℃) freezing 48 hours, through freeze thawing (＜36 ℃, centrifugal 3000 rev/mins) 20 minutes, filter, filtrate lyophilization (pre-cooling-40 ℃, vacuum 10
2, sublimation temperature＜33 ℃ moisture is lower than 7%) and become brown powder, divide promptly encapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96118724A CN1170578A (en) | 1996-07-17 | 1996-07-17 | Earthworm capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96118724A CN1170578A (en) | 1996-07-17 | 1996-07-17 | Earthworm capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1170578A true CN1170578A (en) | 1998-01-21 |
Family
ID=5125291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96118724A Pending CN1170578A (en) | 1996-07-17 | 1996-07-17 | Earthworm capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1170578A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026683A1 (en) * | 2001-09-05 | 2003-04-03 | Xiaoping Zhu | Health caring product for enhancing immunity and delaying aging |
| WO2007016952A1 (en) * | 2005-07-29 | 2007-02-15 | Matuschka-Greiffenclau Markus | Composition for reducing the risk of alcohol induced esophagenal and oropharyngolaryngeal cancer |
| WO2007017139A1 (en) * | 2005-07-29 | 2007-02-15 | Tima Foundation | Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases |
| CN111450120A (en) * | 2020-04-26 | 2020-07-28 | 安溪县桃源有机茶场有限公司 | Earthworm whole powder and preparation method and application thereof |
-
1996
- 1996-07-17 CN CN96118724A patent/CN1170578A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003026683A1 (en) * | 2001-09-05 | 2003-04-03 | Xiaoping Zhu | Health caring product for enhancing immunity and delaying aging |
| WO2007016952A1 (en) * | 2005-07-29 | 2007-02-15 | Matuschka-Greiffenclau Markus | Composition for reducing the risk of alcohol induced esophagenal and oropharyngolaryngeal cancer |
| WO2007017139A1 (en) * | 2005-07-29 | 2007-02-15 | Tima Foundation | Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases |
| EA012753B1 (en) * | 2005-07-29 | 2009-12-30 | Тима Фаундейшн | Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases |
| US8580750B2 (en) | 2005-07-29 | 2013-11-12 | Tima Foundation | Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases |
| US9402849B2 (en) | 2005-07-29 | 2016-08-02 | Tima Foundation | Composition for moderating alcohol metabolism and for reducing the risk of alcohol induced diseases |
| CN111450120A (en) * | 2020-04-26 | 2020-07-28 | 安溪县桃源有机茶场有限公司 | Earthworm whole powder and preparation method and application thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |