CN1064536C - Full-divergence promoting medicine for curing fourth-phase carcinoma of stomach and its processing method - Google Patents
Full-divergence promoting medicine for curing fourth-phase carcinoma of stomach and its processing method Download PDFInfo
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- CN1064536C CN1064536C CN96101087A CN96101087A CN1064536C CN 1064536 C CN1064536 C CN 1064536C CN 96101087 A CN96101087 A CN 96101087A CN 96101087 A CN96101087 A CN 96101087A CN 1064536 C CN1064536 C CN 1064536C
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Abstract
The present invention discloses a powdered medicine CQF0 prepared from Chinese herbal medicines and a preparation method thereof. The powdered medicine CQF0 is applied to the treatment of phase-four stomach cancer. The powdered medicine CQF0 comprises the main components of 0.75g of garter snake, 0.75g of ground beetle, 0.5g of scorpion, 0.5g of honeycomb and 0.5g of snake slough. The preparation method of the powdered medicine CQF0 comprises the following processing steps in sequence: a, required medicines are prepared proportionally; b, firstly, the honeycomb is put into an iron pan for baking with strong fire until the honeycomb is in black; c, the other medicines are respectively baked for drying with soft fire; d, all the medicines after being dried by baking are mixed, blended in uniformity and pulverized into powder, and the powder is sieve with a sieve of number 6 (the mesh size of the sieve is 150 um(+/-)0.6); e, the sieved powder is fully stirred in uniformity and is separately filled into bags of 3g for each bag.
Description
The present invention relates to a kind of medicine of making based on the herbal prescription of five kinds of lower animals by the theoretical selection of holobiology (full name: promote the powder that ECIWO (Embryo Containing the Information of the Whole Organism) is grown forward, be called for short CQF
0Loose) and preparation method thereof.This medicine is as the application in the medicine of preparation treatment IV phase gastric cancer disease.
China belongs to one of gastric cancer country occurred frequently, and most of morning, intermediate gastric carcinoma patient after the state of an illness is made a definite diagnosis, can obtain system, the sure therapeutic treatment of curative effect, as excision, put, chemotherapy etc.After patients undergo said method treatment, progressively enter late period, or the state of an illness belonged to late period after making a definite diagnosis, how undesirable re-use above-mentioned therapy for treating, and patient is standing painful torment thus.At present, the types of drugs that is used for the treatment of gastric cancer clinically can be divided into chemicals preparation and Chinese herbal and crude drugs preparations two classes substantially, divides injection, tablet and pill several types on the dosage form again.The chemicals preparation that is used for the treatment of gastric cancer, though entering the molecular biology level aspect the research of drug mechanism, but ubiquitous double-edged sword effect (can grow by anticancer, also can suppress normal cell growth) easily causes to human body to have a strong impact on.Because it has influenced Normocellular growth, thereby makes normal cell be stranded in the cancer district, brings out second kind of cancer easily.
Holobiology theory (" Bioholographic diagnostic method " 1987.149-181 of publishing house of Shandong University) is thought: cancer is the ECIWO (Embryo Containing the Information of the Whole Organism) in diapause cancer district on the development time axle; as long as can promote the ECIWO (Embryo Containing the Information of the Whole Organism) of diapause state grows forward; enter blastaea or higher stage of development, but cancer is with regard to normalization.Can promote the ECIWO (Embryo Containing the Information of the Whole Organism) medicine of differentiation and development forward, be called the ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator.Many kinds of medicines all have the effect that promotes that ECIWO (Embryo Containing the Information of the Whole Organism) is grown forward in the Chinese medicine, therefore, can be used for treating cancer.According to the ECIWO (Embryo Containing the Information of the Whole Organism) cancer district diapause opinion of holobiology about cancer mechanism, the peculiar curative effect of these Chinese herbal medicine is exactly to contain more ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator, thereby the ECIWO (Embryo Containing the Information of the Whole Organism) with this diapause of the cancer of making passes the cancer district and the ability of normalization.In containing the thing source property Chinese herbal medicine of more ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator, mostly belong to lower animal, they have abnormal and differentiation and development feature rapidly, and this shows that zootic body contains more ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator.In containing the plant-derived Chinese herbal medicine of more ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator, the promptly abnormal root of hairiness on their leaf or the stem, leaf ftractures more, incises or many compound leaves more, and tuber or tuber are arranged, and the monogony ability is strong, and these character are called the anticancer indication trait of plant.This shows that its inside contains more ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator.Now, the modal symptom of IV phase patients with gastric cancer is a pain, and the most frequently used way of therapeutic treatment is to use analgesics at present, but this punishment way is difficult to reach effective therapeutic effect.At present, being used for the treatment of the Chinese herbal and crude drugs preparations of gastric cancer, mostly is tablet form or pill-type.Be used for, the treatment of early gastric cancer, when dosage form is used the difference difference little, also there is advantage separately in curative effect.But only at the Chinese herbal and crude drugs preparations of IV phase gastric cancer, that reports on the document is few.The clinical symptoms of late gastric cancer often with blocking or partial obstruction, if take with tablet or pill-type, often is difficult to play a role because of vomiting makes medicine.As with the medication of powder type, for high-order partial obstruction patient, for stream sap-shape attitude, be easy to like this swallow during because of drug use, medicine also can directly act on focus more in large area immediately.For the complete obstruction patient, because of medicine is that the powder type is taken, does not need process in digestive tract, to dissolve this process again, and directly act on focus, reach therapeutic purposes.
Prescription composition of the present invention makes up for the guiding theory basis with the holographic embryo theory.Treatment mechanism is to contain multiple ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator in the prescription, and their function is to help the ECIWO (Embryo Containing the Information of the Whole Organism) of diapause to pass through the cancer district on the development time axle and reach normalization.This and be the difference that the western medical treatment theory on order ground has matter to suppress, to kill cancerous cell.Clinical practice through the several years has obtained beyond thought effect, and has not seen significant side effects as yet.
Task of the present invention is that a kind of medicine for the treatment of IV phase gastric cancer and preparation method thereof will be provided, and in treatment IV phase gastric cancer, with long-time alleviations patient misery, prolongs patient's life down to the purpose that is expected to reach healing with the pharmaceutical applications of this process preparation.
Prescription of the present invention is formed and process is finished as follows:
1, medicine is formed: a kind of medicine for the treatment of IV phase gastric cancer is made up of Zaocys, ground beetle, Scorpio, Nidus Vespae, five kinds of Chinese herbal medicine of Periostracum Serpentis.
(1) manufacture method: a kind of manufacture method for the treatment of the medicine of IV phase gastric cancer, its Main Ingredients and Appearance for preparing this medicine is (by % weight) Zaocys 0.75g, ground beetle 0.75g, Scorpio 0.5g, Nidus Vespae 0.5g, Periostracum Serpentis 0.5g, this method comprises the processing step of following order:
A, prepare required medicine in proportion;
B, elder generation put into iron pan with Nidus Vespae and dry by the fire with high heat to black, take out standby;
C, with each the personal slow fire oven dry of other each herbal medicine, take out standby;
D, all are dried by the fire good medicament mixed mix well, grind No. 6 sieves that mesh size 150um ± 0.6 is crossed in the back into powder;
E, will sieve down the end and fully mix thoroughly, be packed as 3g one bag.
(2) using method and consumption: preserve in the drying place, get medicine one bag (3g), use warm boiled water, one time three times, one time one bag.
2, with disease plus-minus, the preparation of prescription medicine and use main method:
(1) asthenic type: be more common in behind the chemicotherapy or operation after, anemia is heavy, pallor is simple and unadorned, appearance edema due to deficiency, fear of cold coldness of the body, unable, shortness of breath and palpitation, have a dizzy spell, fidgets due to deficiency, hyperhidrosis (spontaneous perspiration or night sweat), anorexia are dull, emaciated physique, light red tongue is fat, tongue is white, deficient and thready pulse is unable.
Compound method (code name: CQF
1): with Radix Astragali 30g, Radix Ginseng 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Radix Rehmanniae Preparata 15g, Radix Paeoniae Alba 20g, Colla Corii Asini 10g, Pericarpium Citri Reticulatae 10g, Herba Epimedii 20g, Placenta Hominis 15g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10g, quantitative in proportion, mix, be decocted in water for oral dose, one day one pair, simultaneously with the medicinal liquid medicine (CQF that takes after mixing it with water
0Loose).
(2) obstruction type: under the low-diet difficulty, just spue in short-term after the food, eating in the morning but vomiting out in the evening or vomiting out in the morning what eaten at last night, or food back is prolonged still spues again, and postprandial pain increases the weight of, belch, abdominal part distending pain or companion's pain over the chest and back, deep-thready pulse, pale tongue.
Compound method: (code name: CQF
2) Haematitum 15g, Flos Inulae 15g, half 10g, Caulis Bambusae In Taenia 10g, Flos Caryophylli 6g, Lignum Dalbergiae Odoriferae 6g, Rhizoma Coptidis 9g, Fructus Trichosanthis 12g, quantitatively mixing water decoction in proportion again, one day one pair, simultaneously with the medicinal liquid medicine (CQF that takes after mixing it with water
0Loose).
(3) pain type: gastral cavilty twinge or causalgia, more acute after the food, pain be a persistence, and remission time is lacked or is not alleviated, and sore spot is fixed, and what also have relates to the thoracic dorsal waist, deep-thready pulse or moisten, tongue has petechia.
Compound method; (code name: CQF
3) Radix Paeoniae Alba 30g, Radix Glycyrrhizae 15g or Pollen Typhae 10g, Oletum Trogopterori 10g or Rhizoma Corydalis 12g, Rhizoma Cyperi 10g select two flavors for use with disease, fry in shallow oil together in last a few type decocts.
(4) ascitic type: abdominal distention abdomen drum, drum is greater than expanding, and the food back is expanded heavy or companion's pain, and extremity are cold, and edema is light or heavy, deep-rolling pulse, greasy fur.Compound method: (CQF
4) 12 pieces in Fructus Tsaoko 6g, Radix Aconiti Lateralis Preparata 6g, Rhizoma Zingiberis 6g, Rhizoma Atractylodis Macrocephalae 15g, Poria 20g, Radix Aucklandiae 9g, Cortex Magnoliae Officinalis 9g, Pericarpium Arecae 12g, Fructus Chaenomelis 9g, Semen Plantaginis 12g, Radix Glycyrrhizae 3g, Fructus Jujubae, quantitatively mixing water decoction in proportion, one day one pair, simultaneously with the medicinal liquid medicine (CQF that takes after mixing it with water
0Loose).
The late gastric cancer symptom is complicated and changeable, and is often mixed mutually between several types, during application based on primary symptom, dialectical executing when controlling can correlate mutually, more than the medication of four typings based on water decoction, potion on the one, fry in shallow oil twice for every dose, divide and take for three times, medicine (CQF simultaneously takes after mixing it with water when taking
0Loose), to stable disease, just use this medicine (CQF separately
0).During this medicine is applied to separately, early gastric cancer also has positive effect.
The present invention uses the regulation that the quality of medicinal material standard all meets first each relevant medical material of Pharmacopoeia of the People's Republic of China version in 1985.Details are as follows for the main Chinese medicinal materials rules of the composite medicine of treatment IV phase gastric cancer and pharmacological effect:
(1) Zaocys: be the Colubridae animal, the dry body of Zaocys Zaocysdhamnades.
The property of Chinese materia medica: sweetly put down, return Liver Channel, dispel the wind, collateral dredging, relieving convulsion.
Methylene blue method experiment: the leukaemia is had inhibitory action, can suppress the breathing of people's hepatocarcinoma, stomach cancer cell.
(2) ground beetle: be the female worm dry body of Lian section insecticide eupolyphoge sinensis or Ji eupolyphoge sinensis EupolyhagaSeuSteleophga.
The property of Chinese materia medica: salty-cold, return Liver Channel, broken block up, invigorate blood circulation, eliminating stagnation.
Methylene blue method experiment: can suppress the breathing of human liver cancer cell.
(3) Scorpio: be the dry body of Buthidae animal Scorpio ButhusmartensiiKarsch.
The property of Chinese materia medica: suffering is put down, is returned Liver Channel, dispels the wind, arresting convulsion, relieving convulsion.
Methylene blue method experiment: can suppress human liver cancer cell and breathe.
(4) Nidus Vespae: be wasp section insecticide fruit horse peak Polistes Olivaceous nest.
The property of Chinese materia medica: sweet flat, dispel the wind detoxifcation, detumescence, eliminating stagnation.
Methylene blue method experiment: people's gastric cancer, hepatoma carcinoma cell are had inhibitory action.
(5) Periostracum Serpentis: be the dry epidermis film under sloughing off such as Colubridae animal Elaphe taeniurus Cope Elaphe TaeniuraCope or Zaocys Zaocys dhumnades.
The property of Chinese materia medica: saltyly sweetly put down, return Liver Channel, dispel the wind, reduce phlegm, eliminating stagnation.
Methylene blue method experiment: the zoografting tumor is had inhibitory action.
Effects applications of the present invention is mainly verified by the data of clinical trial: the clinicopathological staging of gastric cancer standard of working out by the gastric cancer study on prevention cooperation meeting of in April, 1978 whole nation is to IV phase Patients with Gastric Cancer 50 examples, the effect test of inventing, male's 34 examples wherein, women's 16 examples.37 years old of age minimum, maximum 81 years old.Wherein through radical-ability stomach resecting operation therapist 26 examples; Through spacious person's 5 examples of putting the operative treatment of short circuit; The control of cutting open the belly is looked into, and can't excise to close abdomen person 4 examples; Due to illness feelings are made a definite diagnosis and are belonged to late period and lose operative treatment opportunity, or because of can not operator 15 examples with other serious disease.All cases all turn out to be IV phase gastric cancer through pathological diagnosis.Mucinous adenocarcinoma 6 examples wherein, undifferentiated carcinoma 4 examples, adenocarcinoma 40 examples.All patients are using this medicine (CQF
0Loose) all do not re-use other therapies after the treatment, and with this medicine (CQF
0Loose) each 3g, give patient and take after mixing it with water for three times on the one.Because of IV phase gastric cancer clinical symptoms intricate, patient's life in some complication serious harms, in clinical trial, clinical manifestation by IV phase gastric cancer, it is divided into asthenic type, obstruction type, pain type and four typings of ascitic type, every type is selected an effective prescription, with the anxious then Chinese traditional treatment principle of Zhi Qibiao, is taking this medicine (CQF
0Loose) time add use mutually control the table prescription.Four used prescription (CQF of typing
1, CQF
2, CQF
3, CQF
4), the medicine compatibility method of its every type prescription adopts the viscera theory of the theory of TCM and differentiation of eight pricipales theory to make up for the basis, increases the weight of to contain in the prescription consumption of ECIWO (Embryo Containing the Information of the Whole Organism) differentiation accelerator Chinese medicine.To the alleviation of patient's state of an illness, use this medicine (CQF separately
0Loose).The improvement situation of the gastric cancer efficacy assessment standard of drafting by the gastric cancer study on prevention cooperation meeting of in JIUYUE, 1978 whole nation and 14 clinical symptoms and sign, and by the quality of life situation of Kano Paderewski point system to the patient, conditions of patients has been carried out the follow-up study situation of half a year and 1-3, then IV phase Patients with Gastric Cancer 50 routine therapeutic outcomes are assessed, clinical trial shows, uses this medicine (CQF
0Loose) prescription treatment IV phase gastric cancer, tumour patient treatment effective percentage reaches 94.7%, and symptom, sign improvement rate reach 96%, and quality of life raising rate reaches 94%.Observe and follow up a case by regular visits to half a year, 1 year, 2 years, 3 years survival rate and be respectively 86%, 76%, 50%, 30%, with Britain in the recent period the 1-3 survival rate 72%, 33%, 13.1% of statistics compare, obviously be better than the foreign treatment effect.That the present invention selects a topic is novel, reasonable in design, rigorous, material is complete, use diagnosis curative effect selection standard standard, classics, through provincial retrieval unit " Scientific and Technical Information Institute, Qingdao City " update search: domestic still do not have " identical prescription ", from the medical literature of present grasp, still do not have the first abroad yet.
The present invention on January 8th, 1 by provincial-level appraisal.Technology of the present invention is simple, and is easy to process, and low, practical, the easily preservation of the cost of drugs of preparing has higher using value and promotional value.
The main reference data:
1, Zhang Yingqing " Bioholographic diagnostic method " Jinan. " publishing house of Shandong University " 1987:149-181.
2, Yu Rencun " traditional Chinese medical science oncology " Beijing. " Science Press " 1983:89-119.
3, " Chinese medicine research reference " 1979.3:148.
4, " foreign medical science digest " 1994.1:54 1995.3:1995.4:248.
5, " disease treatment standard " Guangxi medical science Institute of Social Science Information compiles, Guangxi " People's Press " 1983.428-437.
6, the Pharmacopoeia of the People's Republic of China, Ministry of Health of the People's Republic of China's committee of pharmacopeia are compiled Beijing. " People's Health Publisher " 1,985 first ones.
7、ECIWO?Theory?in?Medicine?Proceedings?ofthe?2nd?international?congress?of?ECIWO?Biology(1992，Osol，Norway)1：609。
Claims (2)
1, a kind of medicine for the treatment of IV phase gastric cancer is characterized in that this medicine made by Zaocys 0.75g, ground beetle 0.75g, Scorpio 0.5g, Nidus Vespae 0.5g, five kinds of Chinese herbal medicine of Periostracum Serpentis 0.5g.
2, a kind of manufacture method for the treatment of the medicine of IV phase gastric cancer, the prescription that it is characterized in that this medicine are Zaocys 0.75g, ground beetle 0.75g, Scorpio 0.5g, Nidus Vespae 0 5g, Periostracum Serpentis 0.5g, and its manufacture method comprises the processing step of following order:
A, in proportion prepare required medicine quantitatively;
B, elder generation put into iron pan with Nidus Vespae and dry by the fire with high heat to black;
C, with Zaocys, ground beetle, Scorpio, Nidus Vespae, Periostracum Serpentis medicine, each personal iron pan is dried with slow fire;
D, Zaocys, ground beetle, Scorpio, Nidus Vespae, the Periostracum Serpentis five tastes medicament mixed of oven dry stirred evenly, grind No. 6 sieves that mesh size 150um ± 0.6 is crossed in the back into powder;
E, will sieve down the end and fully mix thoroughly, it is mixed after, be packed as 3g one bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96101087A CN1064536C (en) | 1996-02-02 | 1996-02-02 | Full-divergence promoting medicine for curing fourth-phase carcinoma of stomach and its processing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96101087A CN1064536C (en) | 1996-02-02 | 1996-02-02 | Full-divergence promoting medicine for curing fourth-phase carcinoma of stomach and its processing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1156033A CN1156033A (en) | 1997-08-06 |
| CN1064536C true CN1064536C (en) | 2001-04-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96101087A Expired - Fee Related CN1064536C (en) | 1996-02-02 | 1996-02-02 | Full-divergence promoting medicine for curing fourth-phase carcinoma of stomach and its processing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106728565A (en) * | 2016-12-06 | 2017-05-31 | 贾玉山 | A kind of scorpio medicine vinegar liquid and preparation method thereof |
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1996
- 1996-02-02 CN CN96101087A patent/CN1064536C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 中医杂志，1983,24(3),14 1983.1.1 杨清龙，牵正散加味治疗偏头痛 * |
| 四川中医，1992,10(6),31 1992.1.1 邹世光，脱敏汤治荨麻疹 * |
| 四川中医，1992,10(6),31 1992.1.1 邹世光，脱敏汤治荨麻疹;中医杂志，1983,24(3),14 1983.1.1 杨清龙，牵正散加味治疗偏头痛 * |
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| CN1156033A (en) | 1997-08-06 |
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