CN104435962A - Pharmaceutical composition for treating dyspeptic diarrhea of piglets and preparation method thereof - Google Patents
Pharmaceutical composition for treating dyspeptic diarrhea of piglets and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating dyspeptic diarrhea of piglets and a preparation method thereof. The pharmaceutical composition comprises the following raw material medicines: lespedeza, alpinia katsumadai, lepista nuda, root of twelve stamen melastoma, rhizoma polygonati, phoenix tree seed, agastache rugosus, raw malt, raw rice sprout, halloysitum album, jagged-leaved oak seed, nutmeg, fructus alpiniae oxyphyllae, the root of three-nerved spicebush, hairyvein agrimony, fortune silene herb with root, rhizoma cibotii, acanthopanax, Rhizoma Drynariae, radix scrophulariae, Angelica sinensis, Radix Ophiopogonis, Schisandra chinensis, plant soot and salt. The pharmaceutical composition disclosed by the invention has the beneficial effects of checking diarrhea, invigorating spleen to promote digestion, warming yang, invigorating spleen, regulating vital energy and promoting transportation and nourishing yin and has the auxiliary effects of dispelling the wind and relieving muscular spasm, the effect of strengthening the body resistance to eliminate pathogenic factors can be achieved, the immunity of the piglets can be improved, the disease resistance is enhanced, and the pharmaceutical composition has the advantages of obvious curative effect, low price, no toxic or harm, zero drug residue, pure natural property, high safety, good convenience, comprehensive functions and drug effect reaching the lesions directly when used for treating the dyspeptic diarrhea of piglets.
Description
Technical field
The present invention relates to field of veterinary, particularly relate to and be a kind ofly used for the treatment of pharmaceutical composition of piglet lienteric dysentery and preparation method thereof.
Background technology
Piglet digestive organs are still undeveloped, digestive function imperfection, and digestive enzyme is not enough, if protein level is too high in piglet diet, after indigested protein enters intestinal, gastrointestinal dysfunction can be caused to cause lienteric dysentery.
Incidence 1. piglet commonly encountered diseases, frequently-occurring disease, before and after ablactation, dysentery accounts for 85 – 90%, general without infectiousness, differentiates with piglet pujos blancos.2. ill age in days: in postnatal a couple of days or multiple before and after 20 ages in days, 1 monthly age reduced later gradually.
Clinical symptoms take dysentery as main 1. simple indigestions: piglet: mostly be yellow paste or watery stool within 10 ages in days, 10-30 ages in days: many grays pasty state or Lycoperdon polymorphum Vitt watery stool 2. toxic indigestion: dysentery is more serious, frequent discharge water sample loose stool, containing a large amount of mucus or blood in excrement, and foul smelling abnormal smells from the patient.
Chinese veterinarian thinks that diet is healthy primary condition.Diet change the raw angry blood of being of essence of water and grain, maintain growth in humans, growth, complete various physiological function, ensure life existence and healthy primary condition.
Normal diet is one of main source of the negative and positive of qi and blood of the activity of sustaining life, but improper diet, be often the reason causing numerous disease.Ingesta mainly relies on taste to digest and assimilate, as improper diet, first can impairing the spleen and stomach, and cause the becoming thoroughly decomposed of taste, transportation capabilities not normal, cause digestive function obstacle; Secondly, can also heat-dissipating, raw expectorant, raw wet, produce all pathological changes, become the pathogenetic major reason of disease.
At present, treatment piglet lienteric dysentery therapeutic scheme, medicine are all limited, do not reach desirable therapeutic effect, and treatment cost are higher.But the Chinese medicine piglet lienteric dysentery initial stage not only has the effects such as the antiviral of western modern medicine, also there is antidiarrheal, strengthening the spleen to promote digestion, warming YANG and strengthening the spleen, regulates the flow of vital energy and helps fortune, and yin nourishing anticreep is main, with the effect that suppressing liver-wind to relieve spasm is auxiliary, can strengthening vital QI to eliminate pathogenic factors, can pigling immunity be improved, strengthen that its resistance against diseases has evident in efficacy, cheap, nonhazardous in treatment piglet lienteric dysentery, no drug residue, pure natural property, safe ready, complete function drug effect go directly the advantages such as focus.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of piglet lienteric dysentery, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, there is strengthening the spleen to promote digestion, warming YANG and strengthening the spleen, regulate the flow of vital energy and help fortune, yin nourishing anticreep simultaneously, can pigling immunity be improved, strengthen that its resistance against diseases has evident in efficacy, cheap, nonhazardous in treatment piglet lienteric dysentery, no drug residue, pure natural property, safe ready, complete function drug effect go directly the advantages such as focus.
In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of piglet lienteric dysentery, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati, Semen Firmianae, Herba Pogostemonis, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Kaolin, Semen querci dentatae, Semen Myristicae, Fructus Alpiniae Oxyphyllae, the Radix Linderae, Herba Agrimoniae, Herba silenes fortunei, Rhizoma Cibotii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Drynariae, Radix Scrophulariae, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Pulvis Fumi Carbonisatus and Sal.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 50-63 weight portion, Semen Alpiniae Katsumadai 45-55 weight portion, amethyst mushroom 40-50 weight portion, Herba Melastomatis dodecandri 27-32 weight portion, Rhizoma Polygonati 31-36 weight portion, Semen Firmianae 22-29 weight portion, Herba Pogostemonis 22-27 weight portion, Fructus Hordei Germinatus 24-28 weight portion, raw Fructus Setariae Germinatus 23-27 weight portion, Kaolin 55-62 weight portion, Semen querci dentatae 65-76 weight portion, Semen Myristicae 40-47 weight portion, Fructus Alpiniae Oxyphyllae 27-33 weight portion, Radix Linderae 12-18 weight portion, Herba Agrimoniae 13-17 weight portion, Herba silenes fortunei 14-17 weight portion, Rhizoma Cibotii 18-23 weight portion, Radix Et Caulis Acanthopanacis Senticosi 32-38 weight portion, Rhizoma Drynariae 31-37 weight portion, Radix Scrophulariae 42-48 weight portion, Radix Angelicae Sinensis 36-44 weight portion, Radix Ophiopogonis 47-53 weight portion, Fructus Schisandrae Chinensis 28-34 weight portion, Pulvis Fumi Carbonisatus 8-13 weight portion and Sal 4-7 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 60 weight portion, Semen Alpiniae Katsumadai 50 weight portion, amethyst mushroom 45 weight portion, Herba Melastomatis dodecandri 30 weight portion, Rhizoma Polygonati 35 weight portion, Semen Firmianae 26 weight portion, Herba Pogostemonis 26 weight portion, Fructus Hordei Germinatus 26 weight portion, raw Fructus Setariae Germinatus 26 weight portion, Kaolin 60 weight portion, Semen querci dentatae 75 weight portion, Semen Myristicae 45 weight portion, Fructus Alpiniae Oxyphyllae 30 weight portion, the Radix Linderae 15 weight portion, Herba Agrimoniae 15 weight portion, Herba silenes fortunei 15 weight portion, Rhizoma Cibotii 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Rhizoma Drynariae 35 weight portion, Radix Scrophulariae 45 weight portion, Radix Angelicae Sinensis 40 weight portion, Radix Ophiopogonis 50 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Pulvis Fumi Carbonisatus 10 weight portion and Sal 5 weight portion.
Described pharmaceutical composition also comprises Radix Cynanchi Otophylli, Rhizoma Humatae Tyermanni, Eumeces Chinensis and Mustela eversmanni lesson..
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 50-63 weight portion, Semen Alpiniae Katsumadai 45-55 weight portion, amethyst mushroom 40-50 weight portion, Herba Melastomatis dodecandri 27-32 weight portion, Rhizoma Polygonati 31-36 weight portion, Semen Firmianae 22-29 weight portion, Herba Pogostemonis 22-27 weight portion, Fructus Hordei Germinatus 24-28 weight portion, raw Fructus Setariae Germinatus 23-27 weight portion, Kaolin 55-62 weight portion, Semen querci dentatae 65-76 weight portion, Semen Myristicae 40-47 weight portion, Fructus Alpiniae Oxyphyllae 27-33 weight portion, Radix Linderae 12-18 weight portion, Herba Agrimoniae 13-17 weight portion, Herba silenes fortunei 14-17 weight portion, Rhizoma Cibotii 18-23 weight portion, Radix Et Caulis Acanthopanacis Senticosi 32-38 weight portion, Rhizoma Drynariae 31-37 weight portion, Radix Scrophulariae 42-48 weight portion, Radix Angelicae Sinensis 36-44 weight portion, Radix Ophiopogonis 47-53 weight portion, Fructus Schisandrae Chinensis 28-34 weight portion, Pulvis Fumi Carbonisatus 8-13 weight portion, Sal 4-7 weight portion, Radix Cynanchi Otophylli 6-13 weight portion, Rhizoma Humatae Tyermanni 7-15 weight portion, Eumeces Chinensis 7-12 weight portion and Mustela eversmanni lesson. 8-15 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 60 weight portion, Semen Alpiniae Katsumadai 50 weight portion, amethyst mushroom 45 weight portion, Herba Melastomatis dodecandri 30 weight portion, Rhizoma Polygonati 35 weight portion, Semen Firmianae 26 weight portion, Herba Pogostemonis 26 weight portion, Fructus Hordei Germinatus 26 weight portion, raw Fructus Setariae Germinatus 26 weight portion, Kaolin 60 weight portion, Semen querci dentatae 75 weight portion, Semen Myristicae 45 weight portion, Fructus Alpiniae Oxyphyllae 30 weight portion, the Radix Linderae 15 weight portion, Herba Agrimoniae 15 weight portion, Herba silenes fortunei 15 weight portion, Rhizoma Cibotii 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Rhizoma Drynariae 35 weight portion, Radix Scrophulariae 45 weight portion, Radix Angelicae Sinensis 40 weight portion, Radix Ophiopogonis 50 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Pulvis Fumi Carbonisatus 10 weight portion, Sal 5 weight portion, Radix Cynanchi Otophylli 7 weight portion, Rhizoma Humatae Tyermanni 9 weight portion, Eumeces Chinensis 11 weight portion and Mustela eversmanni lesson. 12 weight portion.
The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati and Semen Firmianae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Herba Pogostemonis, Fructus Hordei Germinatus and raw Fructus Setariae Germinatus are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
The present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of piglet lienteric dysentery, and the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati and Semen Firmianae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Herba Pogostemonis, Fructus Hordei Germinatus and raw Fructus Setariae Germinatus are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The present invention also provides a kind of preparation method being used for the treatment of the pharmaceutical composition of piglet lienteric dysentery, and the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
The invention has the beneficial effects as follows: pharmaceutical composition of the present invention is with strengthening the spleen to promote digestion, warming YANG and strengthening the spleen, regulate the flow of vital energy and help fortune, heat-clearing and toxic substances removing, yin nourishing anticreep master is auxiliary with suppressing liver-wind to relieve spasm, can strengthening vital QI to eliminate pathogenic factors, can pigling immunity be improved, strengthen that its resistance against diseases has evident in efficacy, cheap, nonhazardous in treatment piglet lienteric dysentery, no drug residue, pure natural property, safe ready, complete function drug effect go directly the advantages such as focus.
Detailed description of the invention
Due to deficiency of spleen-YANG and kidneyYANG, dysfunction of the spleen in transportation, then water is anti-wet, and paddy is anti-stagnant, indigestion, and life is had loose bowels.As insufficiency of kidney-YANG, decline of the fire from the gate of life, can not warm spleen soil, and YIN-cold is golden, sends out as Diarrhoea.Therefore say: " diarrhea due to kidney-dificiency person, diarrhea before dawn is also.It was that insufficiency of kidney-YANG loses originally, can not the sub-spleen of replenishing vital QI with drugs of warm nature, can not prohibit again and be fixed in down, thus after meeting son sun raw when, its gas is depressed, and YIN-cold is counter to be won, then borborygmus is run quickly to ring and done swollen, and rushing down one, two row is peace.This disease is hidden in kidney, should control in lower and in should not controlling " (" Huatuo highly skilled doctor secretly hands down ").Lose in compound: lose and then see anthropophagy's abdominal distention, aqueous-grainy diarrhea etc. in compound.For the corresponding symptom suffering from the appearance of piglet lienteric dysentery.
The invention provides one to have and can nurse one's health Lien Sus domestica stomach function, treatment short treating period, effect be better, residual quantity low while can enhancing immunity and resistivity, Chinese medicine composition of green non-pollution and preparation method thereof.
Wherein, Chinese medicine composition comprises: Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati, Semen Firmianae, Herba Pogostemonis, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Kaolin, Semen querci dentatae, Semen Myristicae, Fructus Alpiniae Oxyphyllae, the Radix Linderae, Herba Agrimoniae, Herba silenes fortunei, Rhizoma Cibotii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Drynariae, Radix Scrophulariae, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Pulvis Fumi Carbonisatus and Sal.Preferably, Radix Cynanchi Otophylli, Rhizoma Humatae Tyermanni, Eumeces Chinensis and Mustela eversmanni lesson. is also comprised.Wherein, Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom invigorating the spleen to clear away damp pathogen is with antidiarrheal, Herba Melastomatis dodecandri, Rhizoma Polygonati, QI invigorating spleen reinforcing, help Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai spleen invigorating, Semen Firmianae, Herba Pogostemonis, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus helps digestion stomach function regulating, fortune is helped to prevent rotten thing from delaying, Kaolin, Semen querci dentatae, Semen Myristicae, Fructus Alpiniae Oxyphyllae is with relieving diarrhea with astringents, the Radix Linderae, Herba Agrimoniae, Herba silenes fortunei, Rhizoma Cibotii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Drynariae the kidney invigorating invigorating YANG, enhancing immunity, Radix Scrophulariae, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Schisandrae Chinensis is to increase liquid anticreep, Pulvis Fumi Carbonisatus, Sal is to regulate electrolyte disturbance, Radix Cynanchi Otophylli, Rhizoma Humatae Tyermanni, Eumeces Chinensis and Mustela eversmanni lesson. suppressing liver-wind to relieve spasm full side compatibility reasonable, rigorous, with warming YANG and strengthening the spleen, regulate the flow of vital energy and help fortune, yin nourishing anticreep is main, suppressing liver-wind to relieve spasm is auxiliary treatment piglet lienteric dysentery, desirable effect can be obtained.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Caulis Seu Folium Lespedezae Bicoloris: sweet; Flat.GUIXIN; Liver Channel.Strong muscle kidney tonifying, invigorating the spleen to clear away damp pathogen.Control dizziness, de-power, snakebite.Clearing heat and moistening lung; Inducing diuresis for treating stranguria syndrome; Hemostasis.Main cough due to lung-heat; Cold, fever; Pertussis; Stranguria; Spit blood; Epistaxis; Hematuria; Have blood in stool.
Semen Alpiniae Katsumadai: pungent, temperature.Return spleen, stomach warp.Drying damp and strengthening spleen, stomach warming preventing or arresting vomiting.For internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, anorexia.
Amethyst mushroom: sweet; Property is put down.Return spleen channel.Invigorating the spleen to clear away damp pathogen.Main prevention foot disorder of QI.
Herba Melastomatis dodecandri: bitter in the mouth; Micro-sweet; Property is put down.Return liver; Spleen; Lung meridian.Invigorating the spleen and replenishing QI.Invigorate blood circulation; Hemostasis; Dampness removing; Removing toxic substances.Main dysmenorrhea; Difficult labour; Puerperal abdonimal pain; Retention of placenta; Metrorrhagia; Leucorrhea; Cough; Spit blood; Dysentery; Jaundice; Drench pain; Chronic malaria; Rheumatalgia; Toothache; Scrofula; Hernia; Traumatic injury impairment caused by overstrain; Venom.
Rhizoma Polygonati: sweet is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Semen Firmianae: sweet in the mouth; Property is put down.GUIXIN; Lung; Stomach warp.Pleasant stomach function regulating; Strengthening the spleen to promote digestion; Hemostasis.Main gastralgia; To get ill from overeating diarrhoea; Hernia; Early whitening of beard and hair; Oral aphthae in children.
Herba Pogostemonis: acrid in the mouth; Slightly warm in nature.Return lung; Spleen; Stomach warp.Dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.Main summertime flu; Cold and heat are had a headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels; Vomiting during pregnancy; Nasal sinusitis; Hands; Tinea pedis.
Fructus Hordei Germinatus: nature and flavor are sweet is flat.Return spleen, stomach warp, Liver Channel.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension." Japan hanako materia medica ": " appetizing, only cholera, relieving restlessness, expectorant, broken crux, can expedite the emergence of tire for warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " anti-nausea, disappear dyspepsia, only acid regurgitation acid regurgitation, antidiarrheal, the wide diaphragm of the stomach that disappears, and control married woman's milk breast and do not receive, and milk is more than for alleviating distention in middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." there is promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn relieving distension.Cure mainly food stagnation not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, and women weans.
Raw Fructus Setariae Germinatus: sweet is flat.Return spleen, stomach warp.The appetizing of fast spleen, the therapeutic method to keep the adverse QI flowing downwards and in, promoting digestion and removing stagnation." herbal classic is met former ": " Fructus Setariae Germinatus, opens spleen feed, alleviating distention in middle-JIAO rapid digestion of food, and can invigorating middle warmer, gram to cut also not like Fructus Hordei Germinatus." " Chinese crude drug handbook ": " control insufficiency of the spleen, the heart is had a stomachache, and distension, pyretic toxicity dysentery, excessive thirst, becomes thin." Compendium of Material Medica: " and the appetizing of fast spleen, the therapeutic method to keep the adverse QI flowing downwards and in, promoting digestion and removing stagnation." help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.
Kaolin: sweet acid; Flat; Nontoxic.Return lung; Large intestine channel.Astringing intestine to stop diarrhea; Hemostasis; Gu de-; Removing dampness sore.Main chronic diarrhea; Chronic dysentery; Bleeding not during menses; Seminal emission; Skin infection is not held back.
Semen querci dentatae: bitter; Puckery; Property is put down.Return spleen; Stomach; Large intestine channel.Relieving diarrhea with astringents.Main diarrhoea; Dysentery.
Semen Myristicae: nature and flavor are pungent; Bitter; Temperature.Spleen; Stomach; Large intestine channel.Warming middle-JIAO astringing intestine to stop diarrhea; Promote qi circulation digestion promoting.Main diarrhea of deficiency type." Bencao Jingshu ": large intestine have burning hot and heatstroke diarrhea of heat type spouting diarrhea, discharging fresh blood stool, stomach-fire toothache and damp and hot stagnant Fang Sheng, dysentery from the beginning of, neither should take.Function has warming middle-JIAO astringing intestine to stop diarrhea; Promote qi circulation digestion promoting.Main diarrhea of deficiency type; Cold-dysentery; Abdominal distention; Lack of appetite is vomitted.
Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature; Enter the heart, spleen, kidney channel.The kidney warming controlling nocturnal emission with astringent drugs reducing urination, expectorant is taken the photograph in warming the spleen appetizing, cures mainly Deficiency and coldness of spleen and stomach; Vomiting; Have loose bowels; Coldly in abdomen to educate; The many salivas of mouth; Enuresis due to deficiency of the kidney; Frequent micturition; Seminal emission; Nebulousurine, the diseases such as many salivas.Fructus Alpiniae Oxyphyllae decoct has the effect of stomach invigorating, diuresis, minimizing salivation.
The Radix Linderae: nature and flavor are pungent, temperature.Enter stomach, kidney channel.Have a respite, warming middle-JIAO, cold expelling, pain relieving.1. all pain cards of the breast abdomen of QI stagnated by cold.This product acrid in the mouth is capable loose, and cold relieving warm in nature, enters lung and declare logical, enters spleen and alleviating distention in middle-JIAO, therefore can circulation of qi promoting dispersing cold for relieving pain.Control the vexed pain of breast abdomen side of body rib, often join Rhizoma Cyperi, Radix Glycyrrhizae is equal to use, control colic of cold type stomachache, how to be equal to use with Fructus Foeniculi, Pericarpium Citri Reticulatae Viride, Rhizoma Alpiniae Officinarum, 2. frequent micturition, the enuresis.The pungent loose temperature of these product is led to, and enters kidney and bladder and warming kidney for dispelling cold, reducing urination for preventing enuresis.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache in face, with the passing of time red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.
Herba silenes fortunei: acrid in the mouth, hardship, property is put down, and returns liver,kidney,spleen warp, has wind-damp dispelling, the meridian dredging, effect of antidiarrheal profit, for rheumatic arthralgia, numbness contracture, the cards such as muscles and bones is ached, dysentery.
Rhizoma Cibotii: bitter, sweet, temperature.Return liver, kidney channel." Mingyi Bielu ": " treatment is lost to drown and do not saved, man's flaccidity of the lower limbs lumbago, and ailment said due to cold or exposure drenches dew, weak breath order Dark, hard ridge, sharp pitching, woman's damaging the spleen and stomach, and joint weighs." " property of medicine opinion ": " control man woman poison wind weak foot, pathogen arthralgia chiefly caused by damp pathogen, kidney qi is weak, tonification man, stricture of vagina muscles and bones." function wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.Cure mainly rheumatic arthralgia, soreness of the waist and knees, weakness of the lower extremities, frequent micturition, the enuresis, leukorrhagia.
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Rhizoma Drynariae: bitter, temperature; Return kidney, Liver Channel.The kidney invigorating bone strengthening, continues and hinders pain relieving." property of medicine opinion ": " five kinds of over strain six types of severe debility disease, mouth (one do ' foot ') hands is not received, upper heat and lower cold for poison in main bone, wind blood pain." " Japan hanako materia medica ": " controls malignant boil, loses rotten meat, parasite killing." " book on Chinese herbal medicine is looked for the truth ": " Rhizoma Drynariae, though similar to Fructus Psoraleae, so always specially to reinforce the kidney the logical heart not as Fructus Psoraleae, and controlling also without removing blood stasis removing blood stasis." the kidney invigorating bone strengthening continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel.Clearing away heat-fire, YIN nourishing and the production of body fluid promoting." detailed outline ": " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat." " Japan hanako materia medica ": " control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strains, and the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." there is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cure mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, enters liver, the heart, spleen channel, benefiting blood and regulating blood circulation, promoting blood circulation to remove obstruction in the collateral, loosening bowel to relieve constipation." Treatise on Febrile Disease with Notes ": " the arteries and veins person house of blood, all blood all belongs to the heart, and all persons of promoting blood circulation must first reinforcing the heart benefit blood, therefore Zhang Zhongjing is controlled brothers and fainted cold, thready pulse being about to disappear person, by the hardship temperature of Radix Angelicae Sinensis to help painstaking effort." " book on Chinese herbal medicine is newly organized ": " Radix Angelicae Sinensis, sweet in the mouth is pungent, temperature, can rise and can fall, the YIN aspect of YANG, nontoxic.Though there is upper purgation to divide, enrich blood then one.Enter the heart, spleen, liver three are dirty.But its property is very dynamic, then QI invigorating in the Qi-tonifying drug entered, then enriches blood in the hematonic entered, without determining merit also." have to enrich blood and invigorate blood circulation, the effect of menstruction regulating and pain relieving, the relieving constipation of profit soup, for cards such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel, restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, the cards such as interior-heat is quenched one's thirst, palpitation and insomnia.
Pulvis Fumi Carbonisatus: also name plant ash, pungent, temperature, cold expelling is subsided a swelling, and warming the spleen stops blooding.Compendium of Material Medica: plant ash, be in stove in the eleventh month of the lunar calendar burn the ash of bavin firewood also.
Sal: bitter, salty, returns stomach, kidney, lung, liver, large intestine channel, small intestine meridian.Function: inducing vomiting, relieve inflammation or internal heat, removing heat from blood, removing toxic substances, softening the hard mass, parasite killing, antipruritic." Mingyi Bielu ": cure mainly food and stop Shangwan, trusted subordinate's distending pain, unconsciousness due to blockage of phlegm in brain, constipation and anuresis, gingiva bleeding gingival hemorrhage, laryngalgia, toothache, corneal nebula, skin infection etc.
Radix Cynanchi Otophylli: sweet, acrid, warm.Slightly poisonous.Expelling wind and removing dampness, removing toxic substances spasmolytic.For rheumatic ostalgia, rubella is scratched where it itches, epilepsy, lyssodexis, venom.
Rhizoma Humatae Tyermanni: sweet light, cool.Expelling wind and removing dampness, heat-clearing and toxic substances removing.Dispelling the wind and dampness pathogens arthralgia pain, jaundice due to damp-heat, cough, asthma, lung abscess, acute mastitis, gingival swelling and pain, diphtheria, gonorrhea, leukorrhagia, snakebite.
Eumeces Chinensis: salty, cold.Removing toxic substances and promoting subsidence of swelling, spasmolytic is dispeled the wind.For tuberculous lymphadenitis, breast carcinoma, lung abscess, epilepsy, rheumatism skin is itched and sore.
Mustela eversmanni lesson.: sweet in the mouth; Warm in nature.GUIXIN; Liver Channel.Function cures mainly: dispel the wind; Spasmolytic; Promoting blood circulation to remove obstruction in the collateral.Main epilepsy; Paralysis; Hemiplegia.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments provide a kind of pharmaceutical composition being used for the treatment of piglet lienteric dysentery, be made up of the raw medicinal material of following parts by weight: Caulis Seu Folium Lespedezae Bicoloris 60 weight portion, Semen Alpiniae Katsumadai 50 weight portion, amethyst mushroom 45 weight portion, Herba Melastomatis dodecandri 30 weight portion, Rhizoma Polygonati 35 weight portion, Semen Firmianae 26 weight portion, Herba Pogostemonis 26 weight portion, Fructus Hordei Germinatus 26 weight portion, raw Fructus Setariae Germinatus 26 weight portion, Kaolin 60 weight portion, Semen querci dentatae 75 weight portion, Semen Myristicae 45 weight portion, Fructus Alpiniae Oxyphyllae 30 weight portion, the Radix Linderae 15 weight portion, Herba Agrimoniae 15 weight portion, Herba silenes fortunei 15 weight portion, Rhizoma Cibotii 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Rhizoma Drynariae 35 weight portion, Radix Scrophulariae 45 weight portion, Radix Angelicae Sinensis 40 weight portion, Radix Ophiopogonis 50 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Pulvis Fumi Carbonisatus 10 weight portion and Sal 5 weight portion.
Its preparation method comprises the following steps:
The first step, Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati and Semen Firmianae are mixed in described ratio, be the dissolve with ethanol of 95% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 1 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Herba Pogostemonis, Fructus Hordei Germinatus and raw Fructus Setariae Germinatus are mixed in described ratio, add the ethanol of the determining alcohol 95% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 1 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 1 times relative to the mixture quality obtained, again heat decoction 2 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
Embodiment 2 pharmaceutical composition 2
Embodiments provide a kind of pharmaceutical composition being used for the treatment of piglet lienteric dysentery, be made up of the raw medicinal material of following parts by weight: Caulis Seu Folium Lespedezae Bicoloris 60 weight portion, Semen Alpiniae Katsumadai 50 weight portion, amethyst mushroom 45 weight portion, Herba Melastomatis dodecandri 30 weight portion, Rhizoma Polygonati 35 weight portion, Semen Firmianae 26 weight portion, Herba Pogostemonis 26 weight portion, Fructus Hordei Germinatus 26 weight portion, raw Fructus Setariae Germinatus 26 weight portion, Kaolin 60 weight portion, Semen querci dentatae 75 weight portion, Semen Myristicae 45 weight portion, Fructus Alpiniae Oxyphyllae 30 weight portion, the Radix Linderae 15 weight portion, Herba Agrimoniae 15 weight portion, Herba silenes fortunei 15 weight portion, Rhizoma Cibotii 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Rhizoma Drynariae 35 weight portion, Radix Scrophulariae 45 weight portion, Radix Angelicae Sinensis 40 weight portion, Radix Ophiopogonis 50 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Pulvis Fumi Carbonisatus 10 weight portion, Sal 5 weight portion, Radix Cynanchi Otophylli 7 weight portion, Rhizoma Humatae Tyermanni 9 weight portion, Eumeces Chinensis 11 weight portion and Mustela eversmanni lesson. 12 weight portion.
Its preparation method is as follows:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
The toxicity test of pharmaceutical composition:
1, trial drug
Choose Caulis Seu Folium Lespedezae Bicoloris 60g, Semen Alpiniae Katsumadai 50g, amethyst mushroom 45g, Herba Melastomatis dodecandri 30g, Rhizoma Polygonati 35g, Semen Firmianae 26g, Herba Pogostemonis 26g, Fructus Hordei Germinatus 26g, raw Fructus Setariae Germinatus 26g, Kaolin 60g, Semen querci dentatae 75g, Semen Myristicae 45g, Fructus Alpiniae Oxyphyllae 30g, Radix Linderae 15g, Herba Agrimoniae 15g, Herba silenes fortunei 15g, Rhizoma Cibotii 20g, Radix Et Caulis Acanthopanacis Senticosi 35g, Rhizoma Drynariae 35g, Radix Scrophulariae 45g, Radix Angelicae Sinensis 40g, Radix Ophiopogonis 50g, Fructus Schisandrae Chinensis 30g, Pulvis Fumi Carbonisatus 10g and Sal 5g mix, and is ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
Cultivation pig farm, Jining City in Shandong Province, in by the end of July, 2013, find nearly 260 30 age in days piglets occur feces be yellow paste just, excrement stench, adhere to perianal, the phenomenon that abdominal circumference increases.Piglet lienteric dysentery is diagnosed as with taking a blood sample according to above-mentioned epidemiology.
Choose the piglet that 90 30 ages in days suffer from piglet lienteric dysentery, 90 piglets are divided into three groups, and be respectively embodiment group 1, embodiment group 2 and matched group, the pig weight of three groups, the aspects such as the state of an illness, all without significant difference, have comparability.Embodiment group 1, embodiment group 2 and matched group use the granule of the powder of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively; Wherein, the using method of powder and granule be by powder or granule according in the part by weight conventional feed of 1:100, feed continuously 3 days; Conventional medicament is the sodium bicarbonate 10-15 piece/times that throws something and feeds to piglet, female young peace 1 parcel/time, 2 times on the one, be used in conjunction 3 days, conventional feed of feeding.Take the body weight of each group of ill piglet before and after treatment respectively, period records recovery from illness situation and the death toll of ill piglet, and calculate average daily gain and cure rate, result as shown in Table 1 and Table 2.Wherein, cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, bouncing; Invalid: clinical symptoms is not improved and even increased the weight of or death.
Table 1 three groups of piglet average weight synopsis
Data from table 1: compared with matched group, the piglet average weight taking medicine of the present invention exceeds 188g and 248g respectively than the piglet taking conventional medicament, and average daily gain exceeds 68g/d and 91g/d respectively.
The therapeutic effect synopsis of table 2 three groups of piglets
Data from table 2: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage that is evident in efficacy, cheap, that have no side effect in treatment piglet lienteric dysentery.
Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effects advantage little, evident in efficacy in treatment piglet lienteric dysentery, but also can be good at the normal growth ensureing piglet.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. be used for the treatment of the pharmaceutical composition of piglet lienteric dysentery, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati, Semen Firmianae, Herba Pogostemonis, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Kaolin, Semen querci dentatae, Semen Myristicae, Fructus Alpiniae Oxyphyllae, the Radix Linderae, Herba Agrimoniae, Herba silenes fortunei, Rhizoma Cibotii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Drynariae, Radix Scrophulariae, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Pulvis Fumi Carbonisatus and Sal.
2. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 50-63 weight portion, Semen Alpiniae Katsumadai 45-55 weight portion, amethyst mushroom 40-50 weight portion, Herba Melastomatis dodecandri 27-32 weight portion, Rhizoma Polygonati 31-36 weight portion, Semen Firmianae 22-29 weight portion, Herba Pogostemonis 22-27 weight portion, Fructus Hordei Germinatus 24-28 weight portion, raw Fructus Setariae Germinatus 23-27 weight portion, Kaolin 55-62 weight portion, Semen querci dentatae 65-76 weight portion, Semen Myristicae 40-47 weight portion, Fructus Alpiniae Oxyphyllae 27-33 weight portion, Radix Linderae 12-18 weight portion, Herba Agrimoniae 13-17 weight portion, Herba silenes fortunei 14-17 weight portion, Rhizoma Cibotii 18-23 weight portion, Radix Et Caulis Acanthopanacis Senticosi 32-38 weight portion, Rhizoma Drynariae 31-37 weight portion, Radix Scrophulariae 42-48 weight portion, Radix Angelicae Sinensis 36-44 weight portion, Radix Ophiopogonis 47-53 weight portion, Fructus Schisandrae Chinensis 28-34 weight portion, Pulvis Fumi Carbonisatus 8-13 weight portion and Sal 4-7 weight portion.
3. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 60 weight portion, Semen Alpiniae Katsumadai 50 weight portion, amethyst mushroom 45 weight portion, Herba Melastomatis dodecandri 30 weight portion, Rhizoma Polygonati 35 weight portion, Semen Firmianae 26 weight portion, Herba Pogostemonis 26 weight portion, Fructus Hordei Germinatus 26 weight portion, raw Fructus Setariae Germinatus 26 weight portion, Kaolin 60 weight portion, Semen querci dentatae 75 weight portion, Semen Myristicae 45 weight portion, Fructus Alpiniae Oxyphyllae 30 weight portion, the Radix Linderae 15 weight portion, Herba Agrimoniae 15 weight portion, Herba silenes fortunei 15 weight portion, Rhizoma Cibotii 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Rhizoma Drynariae 35 weight portion, Radix Scrophulariae 45 weight portion, Radix Angelicae Sinensis 40 weight portion, Radix Ophiopogonis 50 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Pulvis Fumi Carbonisatus 10 weight portion and Sal 5 weight portion.
4. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Radix Cynanchi Otophylli, Rhizoma Humatae Tyermanni, Eumeces Chinensis and Mustela eversmanni lesson..
5. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 50-63 weight portion, Semen Alpiniae Katsumadai 45-55 weight portion, amethyst mushroom 40-50 weight portion, Herba Melastomatis dodecandri 27-32 weight portion, Rhizoma Polygonati 31-36 weight portion, Semen Firmianae 22-29 weight portion, Herba Pogostemonis 22-27 weight portion, Fructus Hordei Germinatus 24-28 weight portion, raw Fructus Setariae Germinatus 23-27 weight portion, Kaolin 55-62 weight portion, Semen querci dentatae 65-76 weight portion, Semen Myristicae 40-47 weight portion, Fructus Alpiniae Oxyphyllae 27-33 weight portion, Radix Linderae 12-18 weight portion, Herba Agrimoniae 13-17 weight portion, Herba silenes fortunei 14-17 weight portion, Rhizoma Cibotii 18-23 weight portion, Radix Et Caulis Acanthopanacis Senticosi 32-38 weight portion, Rhizoma Drynariae 31-37 weight portion, Radix Scrophulariae 42-48 weight portion, Radix Angelicae Sinensis 36-44 weight portion, Radix Ophiopogonis 47-53 weight portion, Fructus Schisandrae Chinensis 28-34 weight portion, Pulvis Fumi Carbonisatus 8-13 weight portion, Sal 4-7 weight portion, Radix Cynanchi Otophylli 6-13 weight portion, Rhizoma Humatae Tyermanni 7-15 weight portion, Eumeces Chinensis 7-12 weight portion and Mustela eversmanni lesson. 8-15 weight portion.
6. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Caulis Seu Folium Lespedezae Bicoloris 60 weight portion, Semen Alpiniae Katsumadai 50 weight portion, amethyst mushroom 45 weight portion, Herba Melastomatis dodecandri 30 weight portion, Rhizoma Polygonati 35 weight portion, Semen Firmianae 26 weight portion, Herba Pogostemonis 26 weight portion, Fructus Hordei Germinatus 26 weight portion, raw Fructus Setariae Germinatus 26 weight portion, Kaolin 60 weight portion, Semen querci dentatae 75 weight portion, Semen Myristicae 45 weight portion, Fructus Alpiniae Oxyphyllae 30 weight portion, the Radix Linderae 15 weight portion, Herba Agrimoniae 15 weight portion, Herba silenes fortunei 15 weight portion, Rhizoma Cibotii 20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion, Rhizoma Drynariae 35 weight portion, Radix Scrophulariae 45 weight portion, Radix Angelicae Sinensis 40 weight portion, Radix Ophiopogonis 50 weight portion, Fructus Schisandrae Chinensis 30 weight portion, Pulvis Fumi Carbonisatus 10 weight portion, Sal 5 weight portion, Radix Cynanchi Otophylli 7 weight portion, Rhizoma Humatae Tyermanni 9 weight portion, Eumeces Chinensis 11 weight portion and Mustela eversmanni lesson. 12 weight portion.
7. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati and Semen Firmianae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Herba Pogostemonis, Fructus Hordei Germinatus and raw Fructus Setariae Germinatus are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
8. the pharmaceutical composition being used for the treatment of piglet lienteric dysentery according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
9. the preparation method being used for the treatment of the pharmaceutical composition of piglet lienteric dysentery as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Caulis Seu Folium Lespedezae Bicoloris, Semen Alpiniae Katsumadai, amethyst mushroom, Herba Melastomatis dodecandri, Rhizoma Polygonati and Semen Firmianae are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Herba Pogostemonis, Fructus Hordei Germinatus and raw Fructus Setariae Germinatus are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
10. the preparation method being used for the treatment of the pharmaceutical composition of piglet lienteric dysentery as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995083A (en) * | 2016-05-30 | 2016-10-12 | 高启忠 | Method for treating porcine diarrheic dehydration |
| CN107095059A (en) * | 2017-05-18 | 2017-08-29 | 佛山市高明区生产力促进中心 | It is a kind of to be effective against the feed for nursing that lower dysentery occurs for piglet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251726A (en) * | 2013-05-21 | 2013-08-21 | 天津必佳药业集团有限公司 | Chinese veterinary drug for treating yellow scours of newborn piglets and preparation method thereof |
| CN103272087A (en) * | 2013-05-27 | 2013-09-04 | 天津生机集团股份有限公司 | Chinese medicinal granules for preventing and treating dysentery of piglets and preparation method thereof |
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2014
- 2014-12-17 CN CN201410779960.2A patent/CN104435962A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251726A (en) * | 2013-05-21 | 2013-08-21 | 天津必佳药业集团有限公司 | Chinese veterinary drug for treating yellow scours of newborn piglets and preparation method thereof |
| CN103272087A (en) * | 2013-05-27 | 2013-09-04 | 天津生机集团股份有限公司 | Chinese medicinal granules for preventing and treating dysentery of piglets and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995083A (en) * | 2016-05-30 | 2016-10-12 | 高启忠 | Method for treating porcine diarrheic dehydration |
| CN107095059A (en) * | 2017-05-18 | 2017-08-29 | 佛山市高明区生产力促进中心 | It is a kind of to be effective against the feed for nursing that lower dysentery occurs for piglet |
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