CN105597013A - Method for preparing traditional Chinese medicine composition for treating post-cholecystectomy syndrome - Google Patents
Method for preparing traditional Chinese medicine composition for treating post-cholecystectomy syndrome Download PDFInfo
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- CN105597013A CN105597013A CN201610075545.8A CN201610075545A CN105597013A CN 105597013 A CN105597013 A CN 105597013A CN 201610075545 A CN201610075545 A CN 201610075545A CN 105597013 A CN105597013 A CN 105597013A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/539—Scutellaria (skullcap)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a method for preparing a traditional Chinese medicine composition for treating post-cholecystectomy syndrome, and relates to the technical field of traditional Chinese medicines. The composition is prepared from the following traditional Chinese medicinal raw materials: purslane, radix curcumae, capillary artemisia, endothelium corneum gigeriae galli, scutellaria baicalensis, mangnolia officinalis, lysimachia christinae hance and rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition can be used for relieving main clinical symptoms of patients with post-cholecystectomy syndrome and remarkably improving the health condition of patients after operation, so that post-operation rehabilitation of the patients can be promoted.
Description
The application be applicant Wang Xueyan propose application for a patent for invention (denomination of invention is: one is treated cholecystectomyRear syndromic Chinese medicine composition and application thereof, application number is: 2014100476183, the applying date is: on February 11st, 2014)Divisional application.
Technical field
The invention belongs to traditional Chinese medicine technical field, relate to a kind of Chinese traditional medicine composition for the treatment of postcholecystectomy syndrome of preparingThe method of thing.
Background technology
Acute and chronic biliary diseases is as cholelithiasis, cholecystitis, clinical common disease, the frequently-occurring disease of gallbladder polyps Deng Shi department of general surgery,Mostly need operation excision gall-bladder, but a lot of patient there will be postcholecystectomy syndrome, morbidity after operation excision gall-bladderRate accounts for the l0%-27% of postcholecystectomy, clinical cardinal symptom has precordial region turgor, feels sick, belch, pour out one's grievances, appetite subtractsMove back, appetite minimizing, jaundice, low fever, dysfunction of liver etc., more than occurring in postcholecystectomy several weeks or several months, women more thanThe male sex, symptom can be brought out by factors such as direct stimulation, alcohol, the greasy foods of feed. In its pathogenesis, become silted up with bileLong-pending, infection of biliary tract and cholesterol metabolic imbalance are closely related.
Summary of the invention
The present invention is according to Traditional Chinese medical theory, through a large amount of screenings to drug component, restructuring, trial, again by a large amount ofExperimental study is made. Therefore, the object of the invention is to by prescription again after the pharmacology of traditional Chinese medicine material is studied,The Chinese medicine composition of the treatment postcholecystectomy syndrome that a kind of curative effect is stable, recurrence rate is low, have no side effect is provided.
The object of the present invention is achieved like this:
Treat a Chinese medicine composition for postcholecystectomy syndrome, this Chinese medicine composition is by the Chinese medicine system of following weight portionStandby forming: purslane 17-24 part, root tuber of aromatic turmeric 9-16 part, oriental wormwood 9-16 part, the membrane of a chicken's gizzard 15-22 part, root of large-flowered skullcap 17-24 part, bark of official magnolia 15-22 parts, desmodium 6-13 part, bighead atractylodes rhizome 6-13 part;
Preferably, treat as mentioned above the Chinese medicine composition of postcholecystectomy syndrome, wherein said Chinese medicine composition byThe Chinese medicine of following weight portion is prepared from: purslane 19-21 part, root tuber of aromatic turmeric 11-13 part, oriental wormwood 11-13 part, the membrane of a chicken's gizzard 17-19Part, root of large-flowered skullcap 19-21 part, bark of official magnolia 17-19 part, desmodium 8-10 part, bighead atractylodes rhizome 8-10 part;
Further preferably, treat as mentioned above the Chinese medicine composition of postcholecystectomy syndrome, wherein said Chinese drug-treated groupCompound is prepared from by the Chinese medicine of following weight portion: 20 parts of purslanes, 12 parts of root tubers of aromatic turmeric, 12 parts of oriental wormwoods, 18 parts of thes membrane of a chicken's gizzard, the root of large-flowered skullcap20 parts, 18 parts of the barks of official magnolia, 9 parts of desmodiums, 9 parts of the bighead atractylodes rhizomes;
The Chinese medicine composition for the treatment of postcholecystectomy syndrome of the present invention, preferably the formulation of preparation is oral formulations, entersOne step preferably this oral formulations is granule.
By experimental results demonstrate, the curative effect of traditional Chinese medicine composition for treating postcholecystectomy syndrome of the present invention is stable,Recurrence rate is low, substantially has no side effect. Therefore, the present invention also provides a kind of product purpose, that is: above-mentioned Chinese medicine composition existsApplication in the medicine of preparation treatment postcholecystectomy syndrome.
The preparation method who above-mentioned each Chinese medicine is prepared into compound granular agent of the present invention, comprises the steps: to take clearlyPurslane 17-24 part of wash clean, root tuber of aromatic turmeric 9-16 part, oriental wormwood 9-16 part, the membrane of a chicken's gizzard 15-22 part, root of large-flowered skullcap 17-24 part, bark of official magnolia 15-22 parts, desmodium 6-13 part and bighead atractylodes rhizome 6-13 part, merge, and boiling twice, adds water for the first time as 10 times of amounts of medicinal material weight,Decoct 1.5h, add water for the second time as 8 times of amounts of medicinal material weight, decoct 1.5h, collecting decoction, decompression at 0.07MPa, 60-70 DEG CThe medicinal extract that while being concentrated into 65 DEG C, relative density is 1.15, adds 95% (v/v) ethanol and makes to reach 75% (v/v) containing alcohol amount, stirs, and leaves standstill24 hours, filter, when filtrate reduced pressure concentration under 0.07MPa, 65 DEG C of conditions becomes to 65 DEG C, relative density is 1.25, and reclaims secondAlcohol, obtains concentrate, and (condition is that EAT is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is by dry concentrate spraying80 DEG C, atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s. ), pulverized 80 mesh sieves, obtain cream powder clearly; According to clear cream powder:The weight ratio of dextrin 1:1-3 claims qinghuo reagent powder, dextrin and appropriate 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is 55%Ethanol water, drops into clear cream powder and dextrin in trough type mixing machine, stirs 20 minutes, slowly adds while stirring 55% ethanol,To making softwood, granulate with 12 order stainless steel sifts, 65-75 DEG C is dried 2 hours, takes out, and cools and obtain described granule.
Show by experimental study, Chinese medicine composition of the present invention has the body's immunity of adjusting, strengthens bodyDefence capability, improve cardio-pulmonary function, improve microcirculation, regulate body fluid electrolyte balance, promote digestive juice secretion, improve digestion meritCan, promote human body metabolism, reduce the effects such as sympathetic excitability, can alleviate the main of the postoperative syndrome patient of gall-bladderClinical symptoms, obviously improve the health status of patients after surgery, thereby promote the recovery of patient's postcholecystectomy. In addition, byComparatively desirable in treatment postcholecystectomy syndrome curative effect, therefore Chinese medicine composition of the present invention has cheapness, effective, poison is secondaryAct on low advantage, can save limited health resources, alleviate society and household economy burden.
Detailed description of the invention
According to traditional Chinese medicine Historical Data Data About, the pharmacologically active of the traditional Chinese medicinal material raw materials that the present invention adopts and source are as follows:
Purslane: have clearing heat and detoxicating, the effect such as stop blooding treating stranguria; Cure mainly acute, subacute dermatitis and enteritis, bacillary dysentery,Treat pyogenic infections from tumour or sore, damage by worms bite, eczema, appendicitis, hookworm disease, banded spore rash and functional uterine bleeding; Select amaranthaceous plant horseThe dry young young stem and leaf of bitterroot;
Root tuber of aromatic turmeric: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice. Be used for through closing dysmenorrhoea chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsyGo mad, jaundice urine is red; Select the dried root of zingiberaceous plant turmeric;
Oriental wormwood: clearing away damp-heat, removing jaundice subcutaneous ulcer. For jaundice oliguria, wet sore itch; Infectious jaundice type hepatitis; Select feverfew mattressThe dry aerial parts of old wormwood artemisia ArtemisiacapillarisThunb.;
The membrane of a chicken's gizzard: stomach strengthening and digestion promoting, arresting seminal emission. Do not disappear for dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission; Select pheasantThe dry inner wall of sandbag of the chicken GallusgallusdomesticusBrisson of animal man of section;
The root of large-flowered skullcap: heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive; For damp-warm syndrome, the heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian is full, rushes downDysentery, jaundice, cough with lung heat, high hot polydipsia, blood-head is told nosebleed, carbuncle sore tumefacting virus, fetal irritability; Select the labiate root of large-flowered skullcapThe dry root of ScutellariabaicalensisGeorgi;
The bark of official magnolia: in main temperature, beneficial gas, gas under dissolving phlegm, controls cholera and stomachache, turgor, cold in the stomach is contrary, vomits in the heart contrary more than, lets out dysentery, drenchesReveal, except frightened, going or staying heat, only dysphoria, thick stomach; Select Magnoliacea plant bark of official magnolia MagnoliaofficinalisRehd.etOr Magnolia bilola MagnoliaofficinalisRehd.etWils.var.bilobaRehd.etWils. Wils.Dry dry hide, Gen Pi and branch skin;
Desmodium: eliminating dampness and heat, treating stranguria, detumescence. Drench for heat, Sha Lin, urinates and puckeryly has a pain, and jaundice urine is red, the carbuncle furunculosis that swells, and poisonous snake stingsWound; Liver and bile stone, lithangiuria; Select being dried of Ofthe Primulaceae Lysimachia christinae LysimachiachristinaeHanceHerb;
The bighead atractylodes rhizome: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive; Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, fromSweat, fetal irritability; Select the dry rhizome of feverfew bighead atractylodes rhizome AtractylodesmacrocephalaKoidz.;
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but guarantor of the present inventionThe scope of protecting is not limited to these embodiment. Every do not deviate from the change of the present invention design or be equal to substitute include of the present inventionWithin protection domain.
The preparation of embodiment 1 Chinese herbal granules
Take 18 parts of 20 parts of 18 parts of 12 parts of 12 parts of 20 parts of purslanes, root tubers of aromatic turmeric, oriental wormwoods, thes membrane of a chicken's gizzard, the roots of large-flowered skullcap, the barks of official magnolia cleaning up,9 parts of 9 parts of desmodiums and the bighead atractylodes rhizomes, merge, and boiling twice, adds water for the first time as 10 times of amounts of medicinal material weight, decocts 1.5h, theSecondary adds water as 8 times of amounts of medicinal material weight, decocts 1.5h, and collecting decoction, while being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG CRelative density is 1.15 medicinal extract, adds 95% (v/v) ethanol and makes to reach 75% (v/v) containing alcohol amount, stirs, and leaves standstill 24 hours, filter,When filtrate reduced pressure concentration under 0.07MPa, 65 DEG C of conditions becomes to 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrate,(condition is that EAT is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, and atomization is pressed by dry concentrate sprayingPower is 0.2 MPa, and spray velocity is 5ml/s. ), pulverized 80 mesh sieves, obtain cream powder clearly; According to clear cream powder: the weight of dextrin 1:3Amount is than claiming qinghuo reagent powder, dextrin and appropriate 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, willClear cream powder and dextrin drop in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making softwood, use12 order stainless steel sifts are granulated, and 65-75 DEG C is dried 2 hours, takes out, and cools and obtain described granule, by every bag of 20g packaging.
The preparation of embodiment 2 Chinese herbal granules
Take 15 parts of 24 parts of 22 parts of 10 parts of 9 parts of 23 parts of purslanes, root tubers of aromatic turmeric, oriental wormwoods, thes membrane of a chicken's gizzard, the roots of large-flowered skullcap, the barks of official magnolia, the gold that clean up12 parts of 8 parts of money grass and the bighead atractylodes rhizomes, merge, and boiling twice, adds water for the first time as 10 times of amounts of medicinal material weight, decocts 1.5h, theSecondary adds water as 8 times of amounts of medicinal material weight, decocts 1.5h, and collecting decoction, while being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG CRelative density is 1.15 medicinal extract, adds 95% (v/v) ethanol and makes to reach 75% (v/v) containing alcohol amount, stirs, and leaves standstill 24 hours, filter,When filtrate reduced pressure concentration under 0.07MPa, 65 DEG C of conditions becomes to 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrate,(condition is that EAT is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, and atomization is pressed by dry concentrate sprayingPower is 0.2 MPa, and spray velocity is 5ml/s. ), pulverized 80 mesh sieves, obtain cream powder clearly; According to clear cream powder: the weight of dextrin 1:3Amount is than claiming qinghuo reagent powder, dextrin and appropriate 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, willClear cream powder and dextrin drop in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making softwood, use12 order stainless steel sifts are granulated, and 65-75 DEG C is dried 2 hours, takes out, and cools and obtain described granule, by every bag of 20g packaging.
The preparation of embodiment 3 Chinese herbal granules
Take 20 parts of 18 parts of 15 parts of 15 parts of 16 parts of 17 parts of purslanes, root tubers of aromatic turmeric, oriental wormwoods, thes membrane of a chicken's gizzard, the roots of large-flowered skullcap, the barks of official magnolia cleaning up,8 parts of 12 parts of desmodiums and the bighead atractylodes rhizomes, merge, and boiling twice, adds water for the first time as 10 times of amounts of medicinal material weight, decocts 1.5h,Add water for the second time as 8 times of amounts of medicinal material weight, decoct 1.5h, collecting decoction, is evaporated to 65 DEG C at 0.07MPa, 60-70 DEG CTime the relative density medicinal extract that is 1.15, add 95% (v/v) ethanol and make to reach 75% (v/v) containing alcohol amount, stir, leave standstill 24 hours, mistakeFilter, when filtrate reduced pressure concentration under 0.07MPa, 65 DEG C of conditions becomes to 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentratedLiquid, (condition is that EAT is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, atomization by dry concentrate sprayingPressure is 0.2 MPa, and spray velocity is 5ml/s. ), pulverized 80 mesh sieves, obtain cream powder clearly; According to clear cream powder: dextrin 1:2.5Weight ratio claim qinghuo reagent powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is that 55% ethanol is water-solubleLiquid, drops into clear cream powder and dextrin in trough type mixing machine, stirs 20 minutes, slowly adds while stirring 55% ethanol, soft to makingMaterial, granulates with 12 order stainless steel sifts, and 65-75 DEG C is dried 2 hours, takes out, and cools and obtain described granule, by every bag of 20g bagDress.
The effectiveness study of embodiment 4 Chinese herbal granules to postcholecystectomy syndrome patient
Gallbladder removal patient 47 examples, male 19 examples, female's 28 examples; Age 33-70 year, average 51.6 ± 4.9 years old. Open abdomen excision gall-bladder 16Example, laparoscopic resection gall-bladder 31 examples. Postcholecystectomy is more than 3 months, postoperative repeatedly occur right upper quadrant of the abdomen or right flank pain orSwollen vexed sense of discomfort, and repeatedly occur detesting the indigestion symptoms such as greasy, abdominal distension, borborygmus, constipation, is diagnosed as that gall-bladder is postoperative to be combinedSimulator sickness. All patients are divided into test group 24 examples at random, and control group is totally 23 examples. Two groups of sexes, age, the course of disease, biochemical indicator, imageThe aspects such as, operation method are there was no significant difference relatively, has comparativity.
Test group patient makes a definite diagnosis and starts to take Chinese herbal granules (by the formulation and technology preparation of the embodiment of the present invention 1 afterwardsBecome), every day is in before the meal and respectively take a bag before dinner early. Anethol trithione sheet 25mg for control group, day takes 3 times. Two groups of equal 4 Zhou WeiyiThe individual course for the treatment of, add up curative effect after treating a course for the treatment of.
The result of two groups of curative effect comparisons is: effective in the routine patient of test group 24 (hypochondriac pain, stomachache and other malaise symptoms disappearLose, do not find obvious positive sign, physico-chemical examination is normal) 19 examples, effectively (hypochondriac pain, stomachache and other malaise symptoms alleviate, the positiveSign and physico-chemical examination improve) 3 examples, invalid (symptom, sign are all unchanged) 2 examples, total effective rate is 91.7%; Control group 23 examplesEffective 12 examples in patient, effective 4 examples, invalid 7 examples, total effective rate is 69.6%.
Claims (3)
1. prepare a method for the Chinese medicine composition for the treatment of postcholecystectomy syndrome, it is characterized in that comprising following techniqueStep: (1) takes 18 parts of 12 parts of 12 parts of 20 parts of purslanes, root tubers of aromatic turmeric, oriental wormwoods, thes membrane of a chicken's gizzard, the root of large-flowered skullcap 20 that clean up by weight9 parts of part, 18 parts of the barks of official magnolia, 9 parts of desmodiums and the bighead atractylodes rhizomes; (2) above raw material is merged, boiling twice, adds water for the first time as medicine10 times of amounts of material weight, decoct 1.5h, add water for the second time as 8 times of amounts of medicinal material weight, decoct 1.5h, collecting decoction,The medicinal extract that while being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.15, adds 95%v/v ethanol and makes to reach containing alcohol amount75%v/v, stirs, and leaves standstill 24 hours, filters, relatively close when filtrate reduced pressure concentration under 0.07MPa, 65 DEG C of conditions becomes to 65 DEG CDegree is 1.25, and reclaims ethanol, obtains concentrate, and by dry concentrate spraying, condition is that EAT is 100 DEG C, leaving air tempBe 80 DEG C, temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s, pulverizes 80 mesh sieves, obtains clearlyCream powder; (3) according to clear cream powder: the weight ratio of dextrin 1:3 claims qinghuo reagent powder, dextrin and appropriate 55% ethanol, and wherein 55% ethanol isRefer to the ethanol water that volumetric concentration is 55%, clear cream powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, stir on limitLimit slowly adds 55% ethanol, to making softwood, granulates with 12 order stainless steel sifts, and 65-75 DEG C is dried 2 hours, takes out, and cools.
2. the method for preparing according to claim 1 the Chinese medicine composition for the treatment of postcholecystectomy syndrome, its feature existsIn: described Chinese medicine composition is oral formulations.
3. the method for preparing according to claim 2 the Chinese medicine composition for the treatment of postcholecystectomy syndrome, its feature existsIn: described oral formulations is granule.
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| CN105106843A (en) * | 2015-09-07 | 2015-12-02 | 江淑芬 | Traditional Chinese medicine composition for treating post-cholecystectomy syndrome |
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