CN115590798B - Double-component bath lotion with anti-allergy and skin tendering effects and preparation method thereof - Google Patents

Abstract

The present invention relates to a two-component shower gel with anti-allergic and skin rejuvenating effects and a preparation method thereof, the two-component shower gel with anti-allergic and skin rejuvenating effects includes a first component and a second component; The first component includes a surfactant, a foam booster, a thickener, a pH regulator and water; the second component includes a moisturizing agent and a conditioning agent; and the conditioning agent includes a strontium-containing compound. The present invention creatively adds strontium-containing compounds into bath products, uses strontium to promote collagen metabolism and formation, induces angiogenesis, promotes cell endothelial proliferation and other biological activities to maintain skin vitality; at the same time, strontium participates in the regulation of nerve transmission and muscle contraction It can relieve the symptoms of skin allergies; when strontium enters the human body, it also plays a role in supplementing trace elements.

Description

A two-component shower gel with anti-allergy and skin rejuvenation effects and preparation method thereof

technical field

The invention belongs to the technical field of daily chemical products, and in particular relates to a two-component shower gel with anti-allergic and skin-rejuvenating effects and a preparation method thereof.

Background technique

Using a suitable shower gel is one of the simplest and easy ways to clean and care for the skin of the whole body in people's daily life, and the shower gel overcomes the shortcomings of soap with a high pH value, easy to cause dry skin, degreasing, and less foam, so it is deeply It is loved by consumers and has become the first choice for people's body cleaners. In recent years, the incidence of sensitive skin has increased significantly. People with sensitive skin caused by the environment, food, hormone abuse and other incentives are deeply troubled by symptoms such as dry skin, itching, tingling, redness and swelling.

CN109464369A discloses a body wash for anti-dermatitis, which contains Chinese herbal medicine extracts made from Cnidium Fructus Cnidii, Safflower, Chinese Yam, Hippocampus, Lobelia, Fangfeng, Coptis Rhizoma, Poria, Prunella vulgaris, Fructus Citrus Citrifolia, Curculigo, and stamen. The shower gel can effectively improve the related symptoms of neurodermatitis and atopic dermatitis, is convenient to use, and has no obvious adverse reaction.

CN113559044A discloses a shower gel for preventing skin diseases, including surfactants, plant extracts, citric acid, essence, humectants, preservatives, chelating agents and deionized water, and the plant extracts include traditional Chinese medicine extracts and Plant essential oils have the functions of antibacterial, antiviral, moisturizing and antipruritic, and regulating skin microenvironment. While antibacterial and antiviral, they can relieve and prevent various skin problems.

The active ingredients in current body cleansers and care products are mostly plant essential oils, protein amino acids, organic skin penetrating agents, oils, and surfactants with cleaning effects. However, most of the organic components are macromolecular substances, and it is not easy to determine the proportion that can be absorbed by skin cells.

Therefore, it is very meaningful to develop a bath product that has skin care conditioning ingredients that are easily absorbed by the skin, safe ingredients, and has both anti-allergic and skin rejuvenating effects.

Contents of the invention

Aiming at the deficiencies of the prior art, the object of the present invention is to provide a two-component shower gel with anti-allergic and skin rejuvenating effects and a preparation method thereof.

To achieve this purpose of the invention, the present invention adopts the following technical solutions:

In a first aspect, the present invention provides a two-component shower gel with anti-allergic and skin rejuvenating effects, the two-component shower gel with anti-allergic and skin rejuvenating effects includes a first component and a second component;

The first component includes a surfactant, a foam booster, a thickener, a pH regulator and water;

The second component includes a moisturizer and a conditioning agent;

The conditioner includes a strontium-containing compound; the strontium-containing compound includes any one or at least two of strontium chloride, strontium chloride hexahydrate, strontium hydroxide, strontium acetate, strontium citrate, strontium gluconate, strontium PCA combination of species.

Strontium is an innate trace element in the human body that is indispensable for maintaining the growth of life. Strontium plays a variety of biological activities in the human body. The particle size of strontium ions is small, and it is easier to penetrate into the skin than organic macromolecules. , the present invention creatively adds strontium-containing compounds into bath products, uses strontium to promote collagen metabolism and formation, induces angiogenesis, promotes cell endothelial proliferation and other biological activities to maintain skin vitality; at the same time, strontium can regulate nerve transmission and muscle Shrinkage can relieve symptoms of skin diseases such as urticaria, chronic eczema, and psoriasis, and relieve skin allergy symptoms; strontium enters the human body and also plays a role in supplementing trace elements.

Simultaneously, the present invention also considers that anionic surfactants are often used in the shower gel, and strontium ions belong to cationic strong electrolyte alkaline earth metals, in order to avoid the following adverse effects caused by the neutralization reaction between anionic surfactants and strontium ions: (1 ) The effect of surfactant and strontium ion can not be brought into full play; (2) shower gel system is unstable, easily produces the phenomenon of demulsification layering; (3) thickener is difficult to play the effect of thickening, the present invention will combine Divide one into two, propose two components to be packaged separately, pump out and mix together when in use, fully ensure the stability and efficacy of each component in the system. In order to solve the problem that metal ions in the shower gel destroy the emulsification system, most of the current methods are to add metal ion chelating agents, such as EDTA salts, but EDTA salts have been identified as persistent organic pollutants and are not environmentally friendly. Therefore, the present invention Also overcome this technical drawback.

The shower gel involved in the present invention is composed of strontium-containing compounds, other conditioning agents, surfactants, thickeners, foam boosters, moisturizers, pH regulators and other components. The raw materials promote each other to make the shower gel It has both anti-allergic and skin rejuvenating effects.

The combination of at least two such as the combination of strontium chloride and strontium chloride hexahydrate, the combination of strontium chloride and strontium acetate, the combination of strontium chloride and strontium hydroxide, the combination of strontium chloride and strontium citrate, etc., Any other combinations can be selected, and details will not be repeated here.

Preferably, the conditioner also includes mulberry leaf extract and Kochia scoparia extract.

Among them, mulberry leaf extract can inhibit elastase, and can prevent and treat acne caused by high male hormones; it can shrink collagen fibers; it can promote the activation of luciferase and has anti-inflammatory effects; The activity of tyrosinase has the effect of whitening. Among them, Kochia scoparia extract has anti-inflammatory, anti-allergic, anti-itching, anti-fungal and other effects. The present invention also creatively finds that the combination of mulberry leaf extract and Kochia scoparia extract with strontium-containing compounds has a synergistic effect on skin antisensitivity.

Preferably, the mass ratio of the mulberry leaf extract, Kochia scoparia extract and the strontium-containing compound is (0.5-5):(0.5-5):6, wherein the specific point value in (0.5-5) can be selected 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, etc. Other specific point values within this value range can be selected, and will not be repeated here.

When the mulberry leaf extract, the Kochia scoparia extract and the strontium-containing compound are combined in a mass ratio of (0.5-5):(0.5-5):6, the effect on skin antisensitivity is more significant.

Preferably, the conditioner also includes Nepeta extract.

The nepeta extract has the functions of improving skin moisture metabolism and soothing. The present invention also creatively finds that the nepeta extract and the strontium-containing compound are used together to have a synergistic effect on skin rejuvenation.

Preferably, the mass ratio of the nepeta extract to the strontium-containing compound is (0.5-5): 6, wherein the specific point value in (0.5-5) can be selected from 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, etc., other specific point values within this value range can be selected, and will not be repeated here.

When the nepeta extract is used in combination with the strontium-containing compound at a mass ratio of (0.5-5):6, its effect on skin rejuvenation is more significant.

Preferably, the conditioner also includes Litsea jasmine extract and/or Dictatorium bark extract.

Among them, Litsea pepper extract has antibacterial function, and white fresh root bark has antibacterial, antibacterial, granulation and antipruritic effects.

Preferably, the surfactant includes any one or a combination of at least two of sodium laureth sulfate, ammonium lauryl sulfate or sodium fatty alcohol ether sulfate.

Surfactants can clean the oil and cutin on the surface of the skin, decompose the dirt, oil and cutin on the surface of the skin, and then use running water to take these dirt away from the skin as the cleaning process proceeds, so as to achieve the cleaning effect. Compared with other types of surfactants, the above-mentioned surfactants can also maintain the oil-water balance of the shower gel system of the present invention and stabilize the system.

The combination of at least two such as the combination of sodium laureth sulfate and ammonium lauryl sulfate, the combination of ammonium lauryl sulfate and sodium fatty alcohol ether sulfate, etc., other arbitrary combinations can be selected, here I won't repeat them one by one.

Preferably, the foam booster includes any one or a combination of at least two of coconut oleic acid monoethanolamide, cocamidopropyl betaine or cocamide.

Further preferably, the foam booster is a combination of coconut oleic acid monoethanolamide, cocamidopropyl betaine and cocamide.

The foam booster in the above specific combination can produce more detailed, dense and rich foam for the shower gel product of the present invention, which can slow down the friction and stimulation to the skin during bathing, and achieve the function of buffering.

Preferably, the thickener comprises polyethylene glycol distearate, polyquaternium-7, PEG-150 distearate, xanthan gum, guar gum, alginate or hydroxyethyl cellulose Any one or a combination of at least two of these elements. Thickeners have the function of thickening and stabilizing the system.

The combination of said at least two such as the combination of polyquaternium-7 and PEG-150 distearate, the combination of xanthan gum and polyethylene glycol distearate, seaweed gum and hydroxyethyl cellulose combination, etc., any other combination can be selected, and will not be repeated here.

Preferably, the moisturizer includes any one or a combination of at least two of hyaluronic acid, sodium hyaluronate, propylene glycol or glycerin.

The combination of the at least two, such as the combination of hyaluronic acid and sodium hyaluronate, the combination of sodium hyaluronate and propylene glycol, the combination of glycerol and hyaluronic acid, etc., any other combination can be selected. I won't repeat them one by one.

Preferably, the hyaluronic acid is a combination of macromolecular hyaluronic acid, medium molecular hyaluronic acid and small molecular hyaluronic acid.

Preferably, the hyaluronate is a combination of macromolecular hyaluronate, medium molecular hyaluronate and small molecular hyaluronate.

The macromolecular hyaluronic acid refers to hyaluronic acid with a molecular weight greater than 5000, the middle molecular hyaluronic acid refers to hyaluronic acid with a molecular weight of 1000-5000, and the small molecular hyaluronic acid refers to hyaluronic acid with a molecular weight less than 1000. acid.

Among them, the macromolecular hyaluronic acid can form a breathable film on the skin surface, making the skin smooth and moist, and can block the invasion of foreign bacteria, dust, and ultraviolet rays to protect the skin from damage; the middle molecular hyaluronic acid can firm the skin, Long-term moisturizing; small molecule hyaluronic acid can penetrate into the dermis, slightly dilate capillaries, increase blood circulation, improve intermediate metabolism, promote skin nutrient absorption, increase skin elasticity, and delay skin aging. Moreover, hyaluronic acid can be combined with strontium ions in strontium-containing compounds to form strontium hyaluronate, which can make the metal ion of strontium more stable in the shower gel system, and avoid the formation of other easy-to-crystallize strontium salts. .

Preferably, the first component includes 15-30% of surfactant, 1-5% of foam booster, Thickening agent 1-5%, pH regulator 0.05-0.5% and water; the second component includes moisturizing agent 5-25%, conditioning agent 5-20% and water.

The mass percent content of the surfactant can be 15%, 18%, 20%, 22%, 25%, 28%, 30% and so on. The mass percent content of the foam booster can be 1%, 2%, 3%, 4%, 5% and so on. The mass percent content of the thickener may be 1%, 2%, 3%, 4%, 5% and so on. The mass percentage content of the pH regulator can be 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% and so on. The mass percent content of the moisturizing agent can be 5%, 8%, 10%, 12%, 15%, 18%, 20%, 25% and so on. The mass percentage content of the conditioner can be 5%, 8%, 10%, 12%, 15%, 18%, 20% and so on.

Other specific point values within the above numerical ranges can be selected, and details will not be repeated here.

Preferably, the first component further includes any one or a combination of at least two of silk protein, penetration enhancers, fragrances, antibacterial agents, moisturizers, and toners.

Preferably, the second component also includes an antimicrobial agent.

Among them, silk protein is rich in polar amino acids, which has excellent performance of regulating humidity and moisturizing; at the same time, it can also inhibit the activity of tyrosinase in melanocytes, thereby inhibiting the formation of melanin, keeping the skin fair and clear, and has a whitening effect; The ability of fat peroxidation is comparable to that of VC, and it has anti-aging skin care effect. Among them, the penetration enhancer such as laurocaprazine is a new type of skin penetration agent, which shows obvious transdermal penetration effect on hydrophilic and lipophilic substances, promotes skin absorption, improves product utilization, and can soften cutin. Enhance skin permeability, it also has synergistic antibacterial and antibacterial effects.

The aromatic agent, such as essence, is used to increase the fragrance of the product, and the fragrance stays after shampooing, which is pleasant. The toner, such as pearl paste, is used to adjust the color and brightness of the system.

In a second aspect, the present invention provides a method for preparing the two-component shower gel with anti-allergic and skin rejuvenating effects according to the first aspect, the preparation method comprising: respectively mixing the first component and the second component The raw materials are mixed separately to obtain the first component and the second component, namely.

The preparation method of the two-component shower gel with anti-allergic and skin rejuvenating effects involved in the present invention is simple and easy to operate, and is very suitable for large-scale industrial production.

Preferably, the preparation method of the first component comprises:

(1) Mix water with surfactant, foam booster and part of thickener to obtain component A;

(2) Mix component A with other remaining raw materials to obtain the first component.

Preferably, the mixing in step (1) is carried out under stirring, and the stirring is carried out at 60-80°C (eg, 60°C, 65°C, 70°C, 75°C, 80°C, etc.).

Preferably, the mixing in step (2) is carried out under stirring, and the stirring is carried out at 40-55°C (such as 40°C, 43°C, 45°C, 50°C, 55°C, etc.).

Preferably, the pH of the first component is 5.5-6.5.

Preferably, the preparation method of the second component includes: stirring each raw material at 45-60°C (such as 45°C, 48°C, 50°C, 55°C, 60°C, etc.) until completely dissolved.

The shower gel prepared by adopting the preparation method with the above-mentioned specific technical parameters has a stable system and long-lasting effect.

In the third aspect, the present invention also provides a body wash essence with anti-allergy and skin rejuvenation effects, said body wash essence includes strontium-containing compound, mulberry leaf extract, Kochia chinensis extract, and Schizonepeta extract;

The strontium-containing compound includes any one of strontium chloride, strontium chloride hexahydrate, strontium hydroxide, strontium acetate, strontium citrate, strontium gluconate, strontium PCA or a combination of at least two.

Preferably, the mass ratio of the mulberry leaf extract, Kochia scoparia extract, Schizonepeta extract to the strontium-containing compound is (0.5-5):(0.5-5):(0.5-5):6.

Preferably, the body wash essence also includes Litsea jasmine extract and/or Dictatorium bark extract.

Compared with the prior art, the present invention has the following beneficial effects:

The present invention creatively adds strontium-containing compounds into bath products, uses strontium to promote collagen metabolism and formation, induces angiogenesis, promotes cell endothelial proliferation and other biological activities to maintain skin vitality; at the same time, strontium participates in the regulation of nerve transmission and muscle contraction It can relieve the symptoms of urticaria, chronic eczema, psoriasis and other skin diseases, and relieve the symptoms of skin allergies; when strontium enters the human body, it also plays a role in supplementing trace elements.

Simultaneously, the present invention also considers that anionic surfactants are often used in the shower gel, and strontium ions belong to cationic strong electrolyte alkaline earth metals, in order to avoid the following adverse effects caused by the neutralization reaction between anionic surfactants and strontium ions: (1 ) The effect of surfactant and strontium ion can not be brought into full play; (2) shower gel system is unstable, easily produces the phenomenon of demulsification layering; (3) thickener is difficult to play the effect of thickening, the present invention will combine Divide one into two, propose two components to be packaged separately, pump out and mix together when in use, fully ensure the stability and efficacy of each component in the system. In order to solve the problem that metal ions in the shower gel destroy the emulsification system, most of the current methods are to add metal ion chelating agents, such as EDTA salts, but EDTA salts have been identified as persistent organic pollutants and are not environmentally friendly. Therefore, the present invention Also overcome this technical drawback.

Furthermore, the present invention creatively finds that mulberry leaf extract and Kochia scoparia extract are used in combination with strontium-containing compounds to have a synergistic effect on skin anti-allergy. The present invention also creatively finds that the Nepeta extract and strontium-containing compounds are used together to have a synergistic effect on skin rejuvenation.

Detailed ways

In order to further illustrate the technical means adopted by the present invention and its effects, the technical solutions of the present invention will be further described below in conjunction with preferred embodiments of the present invention, but the present invention is not limited within the scope of the embodiments.

The part raw material source information involved in following examples and comparative examples is as follows:

Silk protein is hydrolyzed silk protein purchased from Zhengzhou Yukong Biotechnology Co., Ltd.;

Hyaluronic acid is macromolecular hyaluronic acid (Qufu Haixin Biological Products Co., Ltd.), medium molecular hyaluronic acid (Zhengzhou Mingrui Chemical Products Co., Ltd.), small molecular hyaluronic acid (Xi'an Qiannuo Biotechnology Co., Ltd.) A mixture with a mass ratio of 1:2:1;

The preservative is a mixture of Crodaxinol 68 and Xinxinone with a mass ratio of 1:1;

Litsea pepper extract is a product purchased from Shaanxi Gerun Biotechnology Co., Ltd. with a model of 10:1;

Schizonepeta extract is a product purchased from Xi'an Lancao Biotechnology Co., Ltd. with a model of 10:1;

The mulberry leaf extract is a product purchased from Xi'an Enteyuan Biotechnology Co., Ltd. with a model of 10:1;

The root bark extract of Radix Bacillus is the product purchased from Shaanxi Shijiqianxun Biotechnology Co., Ltd. with a model of 10:1;

The Kochia chinensis extract is a product purchased from Xi'an Enteiyuan Biotechnology Co., Ltd. with a model of 10:1;

Sodium lauryl ether sulfate (AES) is the product purchased from Guangzhou Zhonghai Chemical Co., Ltd. model as SLES-70%;

70/ZA的产品；Ammonium lauryl sulfate was purchased from the model of Lichen

70/ZA products;

Fatty alcohol ether sodium sulfate is the product purchased from Guangzhou Baolong International Trade Co., Ltd. model as Texapon N70;

CMEA的产品；Coconut oleic acid monoethanolamide was purchased from Guangzhou Nanjia Chemical Technology Co., Ltd., and the model was BASF

CMEA products;

Cocamidopropyl betaine is a product purchased from Guangzhou Zhonghai Chemical Co., Ltd. model as CAB-35%;

Cocamide DEA is a product purchased from Guangzhou Changhong Chemical Co., Ltd. whose model is Coconut 6501;

Polyethylene glycol distearate is a product purchased from Guangzhou Jiaqi Biotechnology Co., Ltd. model LP-638;

All other raw materials were purchased through commercial channels.

Example 1

This embodiment provides a two-component shower gel with anti-allergic and skin rejuvenating effects, and the formula table is as shown in the following table:

Its preparation method is as follows:

(1) Mix water, surfactant, foam booster and polyethylene glycol distearate uniformly at 70°C to obtain component A;

(2) Mix component A with moisturizer, penetration enhancer, xanthan gum, pH regulator and water in sequence at 45°C to obtain the first component;

(3) Stir the raw materials of the second component at 50° C. until completely dissolved to obtain the second component (essence).

(4) For filling, a special two-component shower gel pump head bottle is used, and the first component and the second component are respectively installed in different positions of the pump head bottle. When using, press the pump head, and the two components will be squeezed out at the same time according to the designed ratio.

Example 2

This embodiment provides a two-component shower gel with anti-allergic and skin rejuvenating effects, and the formula table is as shown in the following table:

Its preparation method is as follows:

(1) Mix water, surfactant, foam booster and polyethylene glycol distearate uniformly at 80°C to obtain component A;

(2) Mix component A with moisturizer, penetration enhancer, xanthan gum, preservative, fragrance, pH regulator, and water in sequence at 50°C to obtain the first component;

(3) Stir the raw materials of the second component at 50° C. until completely dissolved to obtain the second component (essence).

(4) For filling, a special two-component shower gel pump head bottle is used, and the first component and the second component are respectively installed in different positions of the pump head bottle. When using, press the pump head, and the two components will be squeezed out at the same time according to the designed ratio.

Example 3

This example provides a two-component shower gel with anti-allergy and skin rejuvenation effects. The difference between the formula table and Example 1 is that 6% strontium chloride hexahydrate, 1% mulberry leaf extract, and Kochia chinensis extract 1% of the extract was replaced by 6% of strontium chloride hexahydrate and 2% of mulberry leaf extract, and other components and contents remained unchanged. Its preparation method refers to embodiment 1.

Example 4

This example provides a two-component shower gel with anti-allergy and skin rejuvenation effects. The difference between the formula table and Example 1 is that 6% strontium chloride hexahydrate, 1% mulberry leaf extract, and Kochia chinensis extract 1% was replaced by 6% strontium chloride hexahydrate and 2% Kochia chinensis extract, and other components and contents remained unchanged. Its preparation method refers to embodiment 1.

Example 5

This example provides a two-component shower gel with anti-allergy and skin rejuvenation effects. The difference between the formula table and Example 1 is that 6% strontium chloride hexahydrate, 1% mulberry leaf extract, and Kochia chinensis extract 1% of the compound was replaced by 6.2% of strontium chloride hexahydrate, and other components and contents remained unchanged. Its preparation method refers to embodiment 1.

Example 6

This example provides a two-component shower gel with anti-allergic and skin rejuvenating effects. The difference between the formula table and Example 1 is that 6% of strontium chloride hexahydrate and 1% of nepeta extract are replaced by chlorine hexahydrate Strontium 6.2%, other components and content remain unchanged. Its preparation method refers to embodiment 1.

Example 7

This example provides a two-component shower gel with anti-allergic and skin rejuvenating effects. The difference between the formula table and Example 1 is that it lacks Litsea jasmine extract and white fresh bark extract, and other components and contents remain the same. constant. Its preparation method refers to embodiment 1.

Example 8

This embodiment provides a two-component shower gel with anti-allergy and skin rejuvenation effects. The difference between the formula table and Example 1 is that the foam booster consists of 0.7% coconut oleic acid monoethanolamide and cocamidopropyl betaine 2.8% composition, other components and contents remain unchanged. Its preparation method refers to embodiment 1.

Example 9

This embodiment provides a two-component shower gel with anti-allergy and skin rejuvenation effects. The difference between the formula table and Example 1 is that the foam booster is composed of 1% coconut oleic acid monoethanolamide and 2.5% cocoamide. Other components and contents remain unchanged. Its preparation method refers to embodiment 1.

Example 10

This example provides a two-component shower gel with anti-allergic and skin rejuvenating effects. The only difference between the formula table and Example 1 is that the foam booster consists of 2.4% cocamidopropyl betaine and 1.1% cocamide , and other components and contents remained unchanged. Its preparation method refers to embodiment 1.

Comparative example 1

This comparative example provides a two-component shower gel with anti-allergy and skin rejuvenation effects. The difference between the formula table and Example 1 is that 6% strontium chloride hexahydrate, 1% mulberry leaf extract, and Kochia chinensis extract 1% was replaced by 4% mulberry leaf extract and 4% Kochia scoparia extract, and other components and contents remained unchanged. Its preparation method refers to embodiment 1.

Comparative example 2

This comparative example provides a two-component shower gel with anti-allergic and skin rejuvenating effects. The difference between the formula table and Example 1 is that 6% of strontium chloride hexahydrate and 1% of nepeta extract are replaced by nepeta extract 7%, other components and content remain unchanged. Its preparation method refers to embodiment 1.

Comparative example 3

This comparative example provides a two-component shower gel with anti-allergic and skin rejuvenating effects. The difference between the formula table and Example 1 is that it does not contain strontium chloride hexahydrate, and the other components and contents remain unchanged. Its preparation method refers to embodiment 1.

test case 1

The shower gel that embodiment 1-10 makes carries out safety performance evaluation:

Select 100 social volunteers who meet the requirements, aged 20-45 years old, and divide them into 10 groups at random, with 5 women and 5 men in each group, try out the shower gels made in Embodiment 1-10 respectively by groups, put them into spots In the test chamber, the control wells were not treated. Apply the spot test device with the test substance on the inner forearm of the subject with hypoallergenic tape, and gently press it with the palm of the hand to make it evenly applied to the skin for 24 hours. Observe the skin reaction according to the standards in Table 1 at 30min (after the indentation disappears), 24h and 48h after removing the plaque device of the test object.

Table 1

The results show that: Examples 1-10 of the present invention are all negative reactions, indicating that the shower gel involved in the present invention is safe and mild, and will not produce adverse reactions such as skin irritation and sensitization.

test case 2

Antiallergic effect test is carried out to the shower gel that embodiment 1,3-7 and comparative example 1-3 make:

Hyaluronic acid is a component that limits the diffusion of water and other extracellular substances in the tissue matrix. After being hydrolyzed by hyaluronidase, the intercellular space becomes non-adhesive, causing cell degranulation and the exudation of new media synthesized to exert biological effects. Lead to the occurrence of immediate hypersensitivity reactions. Hyaluronidase is a participant in allergic reactions and has a strong correlation with allergies. It can relieve allergies and improve skin by inhibiting the activity of hyaluronidase.

The in vitro anti-allergy efficacy of the shower gels prepared in Examples 1, 3-7 and Comparative Examples 1-3 was investigated by hyaluronidase inhibition method.

Get 0.1mL CaCl _solution (0.25mmol/L) and 0.5mL hyaluronidase solution (100U/mL) and react in a 37°C water bath for 20min; add the second component (essence essence) prepared in each embodiment and comparative example ) 0.5mL, keep warm for 20min; then add 0.5mL sodium hyaluronate solution (0.5g/L), react for 30min, take out and cool for 5min; add 0.1mL sodium hydroxide solution (0.4mol/L) and 0.5mL acetylacetone solution ( 3.5mL of acetylacetone dissolved in 50mL of 1.0mol/L sodium carbonate solution), boiling water bath for 15min, immediately transferred to ice-water bath for 5min; dropwise added 1mL of Ehrlich reagent (0.8g of p-dimethylaminobenzaldehyde dissolved in 15mL of concentrated hydrochloric acid and 15mL of absolute ethanol), and diluted with 3mL of absolute ethanol, placed at 25°C for 20min to develop color, and its absorbance was measured at 540nm, and the hyaluronidase inhibition rate was calculated according to the following formula:

Hyaluronidase inhibition rate = {[(A-B)-(C-D)]/(A-B)}×100%

In the formula: A——control solution absorbance (use acetic acid buffer solution to replace sample solution); B—control blank solution absorbance (use acetic acid buffer solution to replace sample solution and enzyme solution); C——sample solution absorbance; D——sample Absorbance of blank solution (use acetate buffer solution instead of enzyme solution).

The results are shown in Table 2:

Table 2

It can be seen from the data in Table 2 that the essence components in the shower gel involved in the present invention have a good inhibitory effect on hyaluronidase, the inhibition rate is above 84.1%, and have a significant anti-allergic effect on the skin. Moreover, the strontium-containing compound, mulberry leaf extract, and Kochia scoparia extract can mutually promote the anti-allergy effect of the product, which verifies the rationality of the composition compatibility.

Test case 3

Human body evaluation test is carried out to the shower gel that embodiment 1-10 and comparative example 1-3 make:

130 volunteers were selected, aged 20-45, half male and half male, and randomly divided into 13 groups. Volunteers in groups 1-13 used the shower gels prepared in Examples 1-10 and Comparative Examples 1-3, once every 2 days, and the amount used by each group remained basically the same, and the time it stayed on the skin each time Keep basically the same, continue to use for 60 days, the volunteers scored the situation of skin elasticity and soothing effect respectively, wherein the highest score is 5 points, the lowest score is 1 point, take integer value, the evaluation results are shown in Table 3 (average score).

table 3

From the data in Table 3, it can be seen that the shower gel involved in the present invention has significant anti-allergy and skin rejuvenation effects. Moreover, the strontium-containing compound, mulberry leaf extract, and Kochia scoparia extract can mutually promote the anti-allergic effect of the product, and the strontium-containing compound and Schizonepeta extract can mutually promote the product's skin rejuvenation effect. The rationality of the allocation.

Use the Corneometer CM 825 skin moisture content tester to measure the skin moisture content MMV of the inner left upper arm of the subject before and after use, calculate the growth rate of skin moisture content according to the following formula, and take the average value. The test results are shown in Table 4 below.

Moisture content growth rate = (MMV _t -MMV ₀ )/MMV ₀

In the formula, MMV ₀ is the skin MMV before use; MMV _t is the skin MMV in the period t after use.

The results are shown in Table 4 (mean score).

Table 4

From the data in Table 4, it can be seen that the shower gel involved in the present invention has a significant moisturizing and rejuvenating effect on the skin. Moreover, the strontium-containing compound and Nepeta extract can mutually promote the product's moisturizing and skin rejuvenating effect, which verifies the rationality of the composition compatibility.

Test case 4

Carry out foam force evaluation test to the shower gel that embodiment 1,8-10 makes:

The foaming ability of the shower gel was evaluated by Roche Foam Tester. First start the super constant temperature water bath to make it reach 40°C, and at the same time make the temperature of the pipe jacket water bath consistent; weigh 2.5g of sample in a 1L volumetric flask, add 150ppm hard water (accurately weigh MgSO ₄ .7H ₂ O 0.148g and CaCl ₂ 0.0999g in a 1L volumetric flask, dilute with distilled water to the mark) to the mark, shake gently, heat it to 40°C for measurement; rinse the inner wall of the graduated tube with distilled water and then rinse with the test solution, close the piston of the graduated tube, Use another dropper to inject 50mL of test solution, let it stand for 1min, adjust the piston so that the liquid level is just at the 50mL mark; fill the dropper with 200mL of test solution, place the dropper on the prepared tube stand and The cross-section of the scale tube becomes vertical, so that the solution flows to the center of the scale tube; open the drip tube piston, and the solution flows down, and when the solution has flowed out, start the stopwatch, and record the height of the foam after 5 minutes (each group of tests is repeated three times, with average statistics). The results are shown in Table 5.

table 5

sample name Foam height(mm) Example 1 153 Example 8 127 Example 9 133 Example 10 141

From the data in Table 5, it can be seen that the shower gel involved in the present invention has the characteristics of fast foaming and many foams. Visible by the contrast of embodiment 1 and embodiment 8-10, in the shower gel of the present invention, coconut oleic acid monoethanolamide, cocamidopropyl betaine and cocamide are synergistic as the foam booster of shower gel, Lack of either ingredient will negatively affect its lathering effect. The rationality of the product component formula of the present invention is verified.

The applicant declares that the present invention illustrates a two-component shower gel with anti-allergic and skin rejuvenating effects and its preparation method through the above-mentioned examples, but the present invention is not limited to the above-mentioned examples, that is, it does not mean The present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, the equivalent replacement of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc., all fall within the scope of protection and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solutions of the present invention. These simple modifications All belong to the protection scope of the present invention.

In addition, it should be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable way if there is no contradiction. The combination method will not be described separately.

Claims (14)

1. A two-component shower gel with anti-allergic and skin rejuvenating effects, characterized in that, the two-component shower gel with anti-allergic and skin rejuvenating effects includes the first component and the second component; Based on the mass of the two-component shower gel with anti-allergic and skin rejuvenating effects as 100%, the first component includes 15-30% of surfactant, 1-5% of foam booster, and 1% of thickener. -5%, pH regulator 0.05-0.5% and water; the second component includes moisturizing agent 5-25%, conditioning agent 5-20% and water; The conditioner is composed of strontium-containing compound, mulberry leaf extract, Kochia scoparia extract, Schizonepeta extract, Litsea pepper extract and white fresh bark extract; the mulberry leaf extract, Kochia scoparia extract The mass ratio to the strontium-containing compound is (0.5-5):(0.5-5):6; the mass ratio of the nepeta extract to the strontium-containing compound is (0.5-5):6; The strontium-containing compound includes any one of strontium chloride, strontium chloride hexahydrate, strontium hydroxide, strontium acetate, strontium citrate, strontium gluconate, strontium PCA or a combination of at least two. 2. the two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 1, is characterized in that, described tensio-active agent is sodium laureth sulfate, ammonium lauryl sulfate and fatty alcohol ether Any one or a combination of at least two of sodium sulfates. 3. the two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 1, characterized in that, the foam booster is coconut oleic acid monoethanolamide, cocamidopropyl betaine and coconut oil Any one or a combination of at least two amides. 4. The two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 1, characterized in that, the thickener is Polyethylene Glycol Distearate, Polyquaternium-7, Any one or a combination of at least two of PEG-150 distearate, xanthan gum, guar gum, seaweed gum and hydroxyethyl cellulose. 5. The two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 1, wherein the moisturizing agent is any one of hyaluronic acid, sodium hyaluronate, propylene glycol and glycerin one or a combination of at least two. 6. The two-component shower gel with anti-allergy and skin rejuvenation effects according to claim 5, wherein said hyaluronic acid is macromolecular hyaluronic acid, middle molecular hyaluronic acid and small molecular hyaluronic acid The combination. 7. The two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 1, characterized in that, the first component also includes silk protein, penetration enhancer, fragrance, antibacterial agent, moisturizing agent , any one of toners or a combination of at least two. 8. The two-component body wash according to claim 1, wherein the second component further comprises an antibacterial agent. 9. The preparation method of the two-component shower gel with anti-allergy and skin rejuvenation effects according to any one of claims 1-8, characterized in that, the preparation method comprises: respectively mixing the first component and the second The raw materials in the two components are mixed separately to obtain the first component and the second component, namely. 10. the preparation method of the two-component shower gel with anti-allergy and skin rejuvenation effect according to claim 9, is characterized in that, the preparation method of described first component comprises: (1) Mix water with surfactant, foam booster and part of thickener to obtain component A; (2) Mix component A with other remaining raw materials to obtain the first component. 11. The preparation method of the two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 10, characterized in that the mixing in step (1) is carried out under stirring, and the stirring is carried out at 60-80°C next. 12. The preparation method of the two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 10, characterized in that the mixing in step (2) is carried out under stirring, and the stirring is carried out at 40-55°C next. 13. The preparation method of the two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 10, characterized in that the pH value of the first component is 5.5-6.5. 14. The method for preparing the two-component shower gel with anti-allergic and skin rejuvenating effects according to claim 9, characterized in that, the method for preparing the second component comprises: mixing each raw material at 45-60°C Stir until completely dissolved.