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CN114728952A - 一种鲁拉西酮盐酸盐的制备方法 - Google Patents

一种鲁拉西酮盐酸盐的制备方法 Download PDF

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Publication number
CN114728952A
CN114728952A CN202080081396.0A CN202080081396A CN114728952A CN 114728952 A CN114728952 A CN 114728952A CN 202080081396 A CN202080081396 A CN 202080081396A CN 114728952 A CN114728952 A CN 114728952A
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CN
China
Prior art keywords
lurasidone
hydrochloric acid
acid solution
hydrochloride
ethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202080081396.0A
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English (en)
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CN114728952B (zh
Inventor
张一凯
黄钧正
卢浩
郭效文
姜亚飞
高源海
黄鲁宁
陶安平
安建国
顾虹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Syncores Technologies Inc ltd
Zhejiang Huahai Pharmaceutical Co Ltd
Original Assignee
Shanghai Syncores Technologies Inc ltd
Zhejiang Huahai Pharmaceutical Co Ltd
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Publication of CN114728952A publication Critical patent/CN114728952A/zh
Application granted granted Critical
Publication of CN114728952B publication Critical patent/CN114728952B/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本发明提供了一种盐酸鲁拉西酮的制备方法，包括在醇类溶剂和卤代烷类溶剂的混合溶剂中，鲁拉西酮游离碱与盐酸反应得到盐酸鲁拉西酮。本发明提供的方法，收率高，成本低，安全性高，残留溶剂低，非常适合工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080081396.0A 2019-12-24 2020-12-07 一种鲁拉西酮盐酸盐的制备方法 Active CN114728952B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019113466835 2019-12-24
CN201911346683.5A CN113024535B (zh) 2019-12-24 2019-12-24 一种鲁拉西酮盐酸盐的制备方法
PCT/CN2020/134285 WO2021129364A1 (zh) 2019-12-24 2020-12-07 一种鲁拉西酮盐酸盐的制备方法

Publications (2)

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CN114728952A true CN114728952A (zh) 2022-07-08
CN114728952B CN114728952B (zh) 2024-08-20

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US (1) US20230037151A1 (zh)
CN (2) CN113024535B (zh)
WO (1) WO2021129364A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115043830A (zh) * 2022-07-01 2022-09-13 浙江美诺华药物化学有限公司 一种鲁拉西酮二盐酸盐晶型的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012123858A1 (en) * 2011-03-14 2012-09-20 Ranbaxy Laboratories Limited Amorphous lurasidone hydrochloride
WO2013132511A1 (en) * 2012-03-09 2013-09-12 Hetero Research Foundation Novel polymorph of lurasidone hydrochloride
CN104031041A (zh) * 2013-03-06 2014-09-10 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型及其制备方法
CN106397424A (zh) * 2016-03-30 2017-02-15 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮氧化杂质的一种制备方法
CN106518729A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮中间体的制备方法
CN106916151A (zh) * 2015-12-28 2017-07-04 苏州二叶制药有限公司 一种盐酸鲁拉西酮的制备方法
WO2017154021A1 (en) * 2016-03-09 2017-09-14 Zcl Chemicals Ltd. An improved process for the preparation of lurasidone base and its salt
CN110114063A (zh) * 2017-01-06 2019-08-09 广东东阳光药业有限公司 鲁拉西酮固体分散体及其制备方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012123858A1 (en) * 2011-03-14 2012-09-20 Ranbaxy Laboratories Limited Amorphous lurasidone hydrochloride
WO2013132511A1 (en) * 2012-03-09 2013-09-12 Hetero Research Foundation Novel polymorph of lurasidone hydrochloride
CN104031041A (zh) * 2013-03-06 2014-09-10 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型及其制备方法
CN109705112A (zh) * 2013-03-06 2019-05-03 江苏恩华药业股份有限公司 盐酸鲁拉西酮的新晶型的制备方法
CN106916151A (zh) * 2015-12-28 2017-07-04 苏州二叶制药有限公司 一种盐酸鲁拉西酮的制备方法
WO2017154021A1 (en) * 2016-03-09 2017-09-14 Zcl Chemicals Ltd. An improved process for the preparation of lurasidone base and its salt
CN106397424A (zh) * 2016-03-30 2017-02-15 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮氧化杂质的一种制备方法
CN106518729A (zh) * 2016-09-21 2017-03-22 北京万全德众医药生物技术有限公司 盐酸鲁拉西酮中间体的制备方法
CN110114063A (zh) * 2017-01-06 2019-08-09 广东东阳光药业有限公司 鲁拉西酮固体分散体及其制备方法

Also Published As

Publication number Publication date
CN113024535B (zh) 2024-08-02
CN113024535A (zh) 2021-06-25
US20230037151A1 (en) 2023-02-02
WO2021129364A1 (zh) 2021-07-01
CN114728952B (zh) 2024-08-20

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