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CN112569272A - Traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and preparation method thereof - Google Patents

Traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and preparation method thereof Download PDF

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CN112569272A
CN112569272A CN202011638437.XA CN202011638437A CN112569272A CN 112569272 A CN112569272 A CN 112569272A CN 202011638437 A CN202011638437 A CN 202011638437A CN 112569272 A CN112569272 A CN 112569272A
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李浩然
施钧瀚
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Henan Jinsizhi Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne, which comprises the following components in parts by weight: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water. The invention adopts a pure natural traditional Chinese medicine preparation, has low toxic and side effects, and the Huatuo beans have the effects of clearing away heat and toxic materials, sterilizing and relieving itching, removing blood stasis and promoting tissue regeneration, diminishing inflammation and relieving pain; the oleum Lavandula Angustifolia has antibacterial, anti-inflammatory and scar removing effects; the carrier matrix can permeate various active ingredients of medicinal materials into skin tissue, and has effects of sterilizing, disinfecting, diminishing inflammation, relieving pain, promoting tissue regeneration, eliminating acne, and improving skin surface tissue.

Description

Traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acnes and a preparation method thereof.
Background
In adolescence, because of the increase of hormones in the body, the human can stimulate the growth of hair and promote sebaceous glands to secrete grease, and a plurality of substances are accumulated on the hair and the sebaceous glands, so that grease and bacteria are attached to the hair and the sebaceous glands, and the breeding of acne is easily caused. In addition, at present, the environmental pollution is serious, dust in the air and the like directly contact with the facial skin and are easily adsorbed on the skin to block pores, and a computer radiation source can also influence the endocrine system of a human body, so that the facial growth of the acne is caused for adolescents in adolescence.
With the increasing aesthetic awareness of people, especially adolescents, whelk patients not only affect the self image, but also affect the social activities of the people due to the appearance, even because other people evaluate that unvanishable shadows are left in the deep inner heart. Therefore, skin care products capable of removing acne and whitening skin are more abundant in the market.
In the existing skin care products, the formula components of the skin care products mostly contain chemical substances, so that the skin is damaged in the process of treating whelk, pockmarks are left, the skin is dull, and even the skin regeneration function of the body is damaged. The traditional Chinese medicine has natural medicinal value and low toxic and side effects, can achieve double effects of skin treatment and skin care when being applied to skin care products and medicines, and becomes a hotspot of current research and development.
Based on the problems, the invention provides a traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes and a preparation method thereof, so as to overcome the problems.
Disclosure of Invention
In order to solve the problems, the embodiment of the invention provides a traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes and a preparation method thereof, and the aim of the invention is realized by the following technical scheme:
a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acnes comprises the following components in parts by weight: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes has the weight unit of gram or kilogram as a metering unit and is determined according to the required quantity.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes is in the form of paste or patch.
The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the following steps: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing Cibotium barometz at a certain ratio to below 200 mesh, decocting with deionized water for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring, melting, cooling to 80 deg.C after completely melting, adding lavender oil in proportion, stirring well to obtain oil phase solution, and keeping warm for use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Latifolius extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution, keeping the temperatureStandby;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring, and mixing uniformly to obtain Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S1Decocting with deionized water 6-10 times of HUATUODOU for 0.5-1.5 hr each time. The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S1Concentrating under reduced pressure to relative density of 1.10-1.15.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S2The melting temperature of the medium heating and stirring is 95-105 ℃.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S4The medium stirring speed is 150-350r/min, and the stirring time is 15-45 min.
The pharmacological effects of the traditional Chinese medicine components of the traditional Chinese medicine composition are as follows:
huatuo beans: cold in nature, bitter in taste; is toxic. Has effects of killing bacteria, relieving itching, removing blood stasis, promoting tissue regeneration, regulating qi, nourishing blood, nourishing yin, invigorating kidney, and enhancing immunity. Purge water and relieve constipation, resolve phlegm and purge water, kill parasites and eliminate accumulation. It can be used for treating edema, constipation, phlegm accumulation, asthma, cough, abdominal pain, ascariasis, and taeniasis.
Lavender oil: the property is mild. Has effects in tranquilizing mind, resisting bacteria, resisting inflammation, resisting oxidation, relieving spasm, relieving pain, reducing blood lipid, and lowering blood pressure. It can be used for treating headache, insomnia, bacterial infection, burn, and arthralgia.
Stearic acid: is mainly used for preparing stabilizers, surfactants, softeners and the like of cosmetics.
Paraffin wax: the preparation method is mainly used for preparing emulsifying agents, dispersing agents, lubricating grease and the like of cosmetics.
Borax: is mainly used for inhibiting bacteria, and has inhibiting effects on Escherichia coli, Pseudomonas aeruginosa, Bacillus anthracis, Shigella flexneri, Bacillus dysenteriae, typhoid bacillus, paratyphoid bacillus, Bacillus proteus, staphylococcus and Candida albicans; borax can also inhibit diphtheria, Brucella bovis, Diplococcus pneumoniae, meningococcus, hemolytic streptococcus, etc.; in addition, borax has the effect of protecting skin mucosa.
Glycerol: the pure glycerin is colorless, odorless, sweet and clear thick liquid, has strong hygroscopicity, can absorb 40% of moisture by being wiped on the skin to form a film, has the effects of isolating the air and preventing the moisture from evaporating, can absorb the moisture in the air, can keep the skin soft and elastic, and is not damaged by dust, weather and the like and dry.
Triethanolamine: in the embodiment of the invention, the emulsifier, the humectant, the moisturizer and the thickener are used. The cream preparation prepared by using the triethanolamine has the advantages of fine and smooth paste and bright white paste; in addition, it has thickening and moisturizing effects.
And (3) nipagin: in the embodiment of the application, the emulsion stabilizer is used as a high-efficiency emulsion stabilizer, and has the effects of sterilization, disinfection and preservation.
Compared with the prior art, the embodiment of the invention at least comprises the following beneficial effects: the acne-removing traditional Chinese medicine composition disclosed by the invention adopts a pure natural traditional Chinese medicine preparation, is low in toxic and side effects, and the Huatuo beans have the effects of clearing away heat and toxic materials, sterilizing and relieving itching, removing blood stasis and promoting tissue regeneration, diminishing inflammation and relieving pain; the oleum Lavandula Angustifolia has antibacterial, anti-inflammatory and scar removing effects; the carrier matrix adopts functional components such as borax, glycerol, triethanolamine, nipagin ester and the like, and efficiently permeates active ingredients of various medicinal materials into skin tissues, so that the traditional Chinese medicine composition achieves the treatment effect, has the effects of sterilizing, disinfecting, diminishing inflammation, relieving pain, removing new tissues, improving and removing whelk, and quickly repairing skin surface tissues.
Detailed Description
It should be understood by those skilled in the art that these embodiments are only for explaining the technical principle of the present invention, and are not intended to limit the scope of the present invention.
A traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acnes comprises the following components in parts by weight: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes has the weight unit of gram or kilogram as a metering unit and is determined according to the required quantity.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes is in the form of paste or patch.
A preparation method of a traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes is disclosed, wherein the traditional Chinese medicine composition is in the form of an ointment and comprises the following components: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing Cibotium barometz at a certain ratio to below 200 mesh, decocting with deionized water for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring, melting, cooling to 80 deg.C after completely melting, adding lavender oil in proportion, stirring well to obtain oil phase solution, and keeping warm for use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The obtained aqueous solution is slowlySlow addition step S2Adding the obtained oil phase solution while stirring, and mixing uniformly to obtain Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S1Decocting with deionized water 6-10 times of HUATUODOU for 0.5-1.5 hr each time. The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S1Concentrating under reduced pressure to relative density of 1.10-1.15.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S2The melting temperature of the medium heating and stirring is 95-105 ℃.
The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes comprises the step S4The medium stirring speed is 150-350r/min, and the stirring time is 15-45 min.
Example 1:
the invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and a preparation method thereof, wherein the traditional Chinese medicine composition is in the form of paste and comprises the following components: 1 part of Huatuo beans, 1 part of lavender oil and an oil phase matrix part: 17 parts of stearic acid, 1.0 part of liquid paraffin and 17 parts of paraffin; the aqueous matrix part is: 0.1 part of borax, 3.0 parts of glycerol, 0.1 part of triethanolamine, 0.2 part of nipagin and 60 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing HUATUODOU bean powder to below 200 mesh, decocting with deionized water 6 times of HUATUODOU for 0.5 hr each time, decocting for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure to relative density of 1.10-1.15;
step S2: adding stearic acid and paraffin into liquid paraffin, heating and stirring at the melting temperature of 95 deg.C for melting, cooling to 80 deg.C, adding oleum Lavandula Angustifolia, and stirring to obtain oil phase solutionKeeping the temperature for later use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring at the stirring speed of 150r/min for 15min, and mixing uniformly to obtain a Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
Example 2:
the invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and a preparation method thereof, wherein the traditional Chinese medicine composition is in the form of paste and comprises the following components: 30 parts of Huatuo beans, 20 parts of lavender oil and an oil phase matrix part: 19 parts of stearic acid, 3.0 parts of liquid paraffin and 19 parts of paraffin; the aqueous matrix part is: 0.5 part of borax, 5.0 parts of glycerol, 0.3 part of triethanolamine, 0.5 part of nipagin and 70 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing HUATUODOU bean powder to below 200 mesh, decocting with 10 times of deionized water for 1.5 hr each time, decocting for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure to relative density of 1.10-1.15;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring and melting at the melting temperature of 105 ℃, cooling to 80 ℃ after complete melting, adding lavender oil in proportion, stirring uniformly to obtain an oil phase solution, and keeping the temperature for later use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Latifolius extract, heating to 80 deg.C for dissolvingAfter complete dissolution, obtaining a water phase solution, and keeping the temperature for later use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring, wherein the stirring speed is 350r/min, the stirring time is 45min, and uniformly mixing to obtain a traditional Chinese medicine mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
Example 3:
the invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and a preparation method thereof, wherein the traditional Chinese medicine composition is in the form of paste and comprises the following components: 15 parts of Huatuo beans, 10 parts of lavender oil and an oil phase matrix part: 18 parts of stearic acid, 2.0 parts of liquid paraffin and 18 parts of paraffin; the aqueous matrix part is: 0.3 part of borax, 4.0 parts of glycerol, 0.2 part of triethanolamine, 0.35 part of nipagin and 65 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing HUATUODOU bean powder to below 200 mesh, decocting with deionized water 8 times of HUATUODOU for 1.0 hr each time for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure to relative density of 1.10-1.15;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring and melting at the melting temperature of 100 ℃, cooling to 80 ℃ after complete melting, adding lavender oil in proportion, stirring uniformly to obtain an oil phase solution, and keeping the temperature for later use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2The resulting oil phase solution was stirred while adding the solution at a stirring speed of 250rStirring for 30min to obtain Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
Example 4:
the invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and a preparation method thereof, wherein the traditional Chinese medicine composition is in the form of paste and comprises the following components: 1 part of Huatuo beans, 20 parts of lavender oil and an oil phase matrix part: 19 parts of stearic acid, 3.0 parts of liquid paraffin and 19 parts of paraffin; the aqueous matrix part is: 0.5 part of borax, 5.0 parts of glycerol, 0.3 part of triethanolamine, 0.5 part of nipagin and 60 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing HUATUODOU bean powder to below 200 mesh, decocting with 10 times of deionized water for 1.5 hr each time, decocting for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure to relative density of 1.10-1.15;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring and melting at the melting temperature of 105 ℃, cooling to 80 ℃ after complete melting, adding lavender oil in proportion, stirring uniformly to obtain an oil phase solution, and keeping the temperature for later use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring, wherein the stirring speed is 350r/min, the stirring time is 45min, and uniformly mixing to obtain a traditional Chinese medicine mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
Example 5:
the invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and a preparation method thereof, wherein the traditional Chinese medicine composition is in the form of paste and comprises the following components: 30 parts of Huatuo beans, 1 part of lavender oil and an oil phase matrix part: 17 parts of stearic acid, 1.0 part of liquid paraffin and 17 parts of paraffin; the aqueous matrix part is: 0.1 part of borax, 3.0 parts of glycerol, 0.1 part of triethanolamine, 0.2 part of nipagin and 70 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing HUATUODOU bean powder to below 200 mesh, decocting with deionized water 8 times of HUATUODOU for 1.0 hr each time for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure to relative density of 1.10-1.15;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring and melting at the melting temperature of 100 ℃, cooling to 80 ℃ after complete melting, adding lavender oil in proportion, stirring uniformly to obtain an oil phase solution, and keeping the temperature for later use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring at a stirring speed of 200r/min for 30min, and mixing uniformly to obtain a Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
Example 6:
the invention discloses a traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and a preparation method thereof, wherein the traditional Chinese medicine composition is in the form of paste and comprises the following components: 10 parts of Huatuo beans, 10 parts of lavender oil and an oil phase matrix part: 18 parts of stearic acid, 2.0 parts of liquid paraffin and 18 parts of paraffin; the aqueous matrix part is: 0.3 part of borax, 4.0 parts of glycerol, 0.2 part of triethanolamine, 0.35 part of nipagin and 65 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing HUATUODOU bean powder to below 200 mesh, decocting with deionized water 6 times of HUATUODOU for 0.5 hr each time, decocting for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure to relative density of 1.10-1.15;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring and melting at the melting temperature of 95 ℃, cooling to 80 ℃ after complete melting, adding lavender oil in proportion, stirring uniformly to obtain an oil phase solution, and keeping the temperature for later use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring at the stirring speed of 150r/min for 15min, and mixing uniformly to obtain a Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
Use effect experiment:
(1) the clinical test of the traditional Chinese medicine composition comprises the following steps:
the traditional Chinese medicine composition ointment with the formula in the embodiments 1-6 of the invention is adopted to carry out a face acne treatment test, 100 patients are respectively selected to prepare the acne treatment traditional Chinese medicine composition with the formula in the embodiments 1-6, the acne treatment traditional Chinese medicine composition is coated on the patients twice a day in the morning, at noon and at night, the test is carried out for 15 days, the acne treatment and whitening conditions of the patients are counted, and the statistical result is shown in table 1:
TABLE 1 clinical trial effect data of Chinese medicinal composition
Group of Number of patients Show effect Improvement of life Invalidation Effective rate (%)
Example 1 100 30 64 6 94
Example 2 100 32 64 4 96
Example 3 100 28 69 3 97
Example 4 100 22 73 5 95
Example 5 100 26 67 7 93
Example 6 100 35 57 8 92
Note: the curative effect standard is as follows: the effect is shown: acne is removed without obvious scars; the method has the following advantages: acne is removed with slight scar; and (4) invalidation: whelk has no obvious change and remains obvious spot.
As can be seen from the table 1, the traditional Chinese medicine composition has a remarkable effect of removing acne of patients, and the ointment of the traditional Chinese medicine composition prepared by the formula has a remarkable bacteriostatic effect.
Part of the typical cases:
case 1: zhangzhi, girl, 1997, 20-30 particles of forehead acne particles, moderate symptoms, poor effect due to wiping by using a conventional acne-removing ointment, 7 months in 2019, application of the traditional Chinese medicine composition ointment for 7 days, basic removal of acne, slight dullness of acne parts, and 1 month later, complete removal of acne and no residual trace.
Case 2: the traditional Chinese medicine composition ointment is externally applied for 7 days, the whelks are completely removed, the skin of the whelk part is smooth, and no obvious residue exists.
Case 3: the Chinese medicinal composition ointment is applied externally for 30 days, the acne is completely removed, and no obvious residue exists at the acne part.
Case 4: the Yaoji, a woman, 1999 raw, the forehead is distributed with a plurality of whelks with mild symptoms, the effect is poor when the conventional acne-removing ointment is wiped, the diagnosis is carried out in 9 months in 2020, the acne is removed by externally applying the traditional Chinese medicine composition ointment for 15 days, and no residual trace is left basically.
Case 5: certain Zhao, men, 2005, have some whelks near the chin, moderate symptoms, visit 1 month in 2019, apply the Chinese medicinal composition ointment externally for 18 days, the whelks are completely removed, the skin is smooth and has no residual traces.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (8)

1. A traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acnes is characterized by comprising the following components in parts by weight: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water.
2. The Chinese medicinal composition with anti-inflammatory, analgesic and acne removing functions according to claim 1, wherein the weight unit of the Chinese medicinal composition is gram or kilogram, and is determined according to the required amount.
3. The traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acnes as claimed in claim 1, wherein the traditional Chinese medicine composition is in the form of an ointment or a patch.
4. The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acne according to claim 1,
the Chinese medicinal composition is in the form of paste and comprises the following components: 1-30 parts of Huatuo beans, 1-20 parts of lavender oil and an oil phase matrix part: 17-19 parts of stearic acid, 1.0-3.0 parts of liquid paraffin and 17-19 parts of paraffin; the aqueous matrix part is: 0.1-0.5 part of borax, 3.0-5.0 parts of glycerol, 0.1-0.3 part of triethanolamine, 0.2-0.5 part of nipagin and 60-70 parts of deionized water;
the preparation method comprises the following steps:
step S1: pulverizing Cibotium barometz at a certain ratio to below 200 mesh, decocting with deionized water for 2 times, filtering, mixing filtrates, and concentrating under reduced pressure;
step S2: adding stearic acid and paraffin in proportion into liquid paraffin, heating, stirring, melting, cooling to 80 deg.C after completely melting, adding lavender oil in proportion, stirring well to obtain oil phase solution, and keeping warm for use;
step S3: adding borax, glycerol, triethanolamine and nipagin in proportion into the step S1Adding appropriate amount of deionized water into the obtained Phaseolus Lauratus (Tuo.) Toue bean extract, adjusting volume, heating to 80 deg.C for dissolving, obtaining water phase solution after completely dissolving, and keeping the temperature for use;
step S4: will step S3The resulting aqueous solution is slowly added to step S2Adding the obtained oil phase solution while stirring, and mixing uniformly to obtain Chinese medicinal mixture;
step S5: will step S4The Chinese medicine mixture is cooled and packed into a container.
5. The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acne according to claim 4, characterized in that the step S is carried out1Decocting with deionized water 6-10 times of HUATUODOU for 0.5-1.5 hr each time.
6. The preparation method of the traditional Chinese medicine composition with the functions of diminishing inflammation, relieving pain and removing acne according to claim 4, characterized in that the step S is carried out1Concentrating under reduced pressure to relative density of 1.10-1.15.
7. The Chinese medicinal composition with the functions of diminishing inflammation, relieving pain and removing acne according to claim 4, wherein the step S is carried out2The melting temperature of the medium heating and stirring is 95-105 ℃.
8. The Chinese medicinal composition with the functions of diminishing inflammation, relieving pain and removing acne according to claim 4, wherein the step S is carried out4The medium stirring speed is 150-350r/min, and the stirring time is 15-45 min.
CN202011638437.XA 2020-12-31 2020-12-31 Traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and preparation method thereof Pending CN112569272A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116549348A (en) * 2022-12-26 2023-08-08 河南金丝指生物科技有限公司 Deep acne removing mask and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1338257A (en) * 2001-09-07 2002-03-06 康德成 A cream for treating dermatoses
CN101336959A (en) * 2008-08-08 2009-01-07 广西博科药业有限公司 Composition with acne-removal function
CN105833029A (en) * 2016-05-10 2016-08-10 来凤县人民医院 Tujia-Miao herbal medicine for treating acne
CN109431903A (en) * 2018-12-21 2019-03-08 河南金丝指生物科技有限公司 A kind of detoxicating, relieving inflammation analgesic anti acne of traditional Chinese medicine prescription facial mask

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1338257A (en) * 2001-09-07 2002-03-06 康德成 A cream for treating dermatoses
CN101336959A (en) * 2008-08-08 2009-01-07 广西博科药业有限公司 Composition with acne-removal function
CN105833029A (en) * 2016-05-10 2016-08-10 来凤县人民医院 Tujia-Miao herbal medicine for treating acne
CN109431903A (en) * 2018-12-21 2019-03-08 河南金丝指生物科技有限公司 A kind of detoxicating, relieving inflammation analgesic anti acne of traditional Chinese medicine prescription facial mask

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
单孔荣,等: "薰衣草精油与罗勒精油对痤疮致病菌的体外抑菌作用研究", 《广东药科大学学报》 *
梁洁,等: "壮药华陀豆醇提物和水提取镇痛抗炎作用的比较研究", 《中华中医药杂志》 *
靳明慧,等: "薰衣草精油对皮肤光老化作用机制研究进展", 《西南医科大学学报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116549348A (en) * 2022-12-26 2023-08-08 河南金丝指生物科技有限公司 Deep acne removing mask and preparation method thereof

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