CN1338257A - A cream for treating dermatoses - Google Patents
A cream for treating dermatoses Download PDFInfo
- Publication number
- CN1338257A CN1338257A CN 01132766 CN01132766A CN1338257A CN 1338257 A CN1338257 A CN 1338257A CN 01132766 CN01132766 CN 01132766 CN 01132766 A CN01132766 A CN 01132766A CN 1338257 A CN1338257 A CN 1338257A
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- CN
- China
- Prior art keywords
- emulsifiable paste
- dermopathic
- vitamin
- another name
- name called
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006071 cream Substances 0.000 title abstract 2
- 208000017520 skin disease Diseases 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims abstract description 9
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims abstract description 9
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 9
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910021538 borax Inorganic materials 0.000 claims abstract description 9
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims abstract description 9
- 229960002867 griseofulvin Drugs 0.000 claims abstract description 9
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 9
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 9
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 9
- 239000008117 stearic acid Substances 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 16
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 7
- 235000019158 vitamin B6 Nutrition 0.000 claims description 7
- 239000011726 vitamin B6 Substances 0.000 claims description 7
- 229940011671 vitamin b6 Drugs 0.000 claims description 7
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 6
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 6
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 3
- 229930003451 Vitamin B1 Natural products 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 229960003495 thiamine Drugs 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 235000010374 vitamin B1 Nutrition 0.000 claims description 2
- 239000011691 vitamin B1 Substances 0.000 claims description 2
- XYMGOIITVXRELK-UHFFFAOYSA-N OC1=C(C(=O)OCC)C=CC=C1.OCC(O)CO Chemical compound OC1=C(C(=O)OCC)C=CC=C1.OCC(O)CO XYMGOIITVXRELK-UHFFFAOYSA-N 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 abstract description 10
- 208000002474 Tinea Diseases 0.000 abstract description 6
- 208000010668 atopic eczema Diseases 0.000 abstract description 6
- 206010000496 acne Diseases 0.000 abstract description 5
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 3
- 241000130764 Tinea Species 0.000 abstract description 2
- 235000013532 brandy Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- -1 liquid paraffin Chemical compound 0.000 abstract 1
- 229940057995 liquid paraffin Drugs 0.000 abstract 1
- 206010005913 Body tinea Diseases 0.000 description 4
- 201000010618 Tinea cruris Diseases 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 201000003875 tinea corporis Diseases 0.000 description 4
- 208000007712 Tinea Versicolor Diseases 0.000 description 3
- 206010056131 Tinea versicolour Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 201000004647 tinea pedis Diseases 0.000 description 3
- 206010012442 Dermatitis contact Diseases 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 2
- 208000019872 Drug Eruptions Diseases 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 201000009053 Neurodermatitis Diseases 0.000 description 2
- 208000010195 Onychomycosis Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 241001303601 Rosacea Species 0.000 description 2
- 206010041303 Solar dermatitis Diseases 0.000 description 2
- 206010043866 Tinea capitis Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000010247 contact dermatitis Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 201000004700 rosacea Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000005882 tinea unguium Diseases 0.000 description 2
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 206010067197 Tinea manuum Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 201000011486 lichen planus Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A cream for treating dermatopathy is prepared from stearic acid, liquid paraffin, triethanolamine, glycerin, nipagin ethyl ester, borax, VB 1, VB 6, griseofulvin, etc through proportional mixing, and serves to treat tinea, eczema, dermatitis, acne, brandy nose, etc.
Description
(1) technical field: the invention belongs to the dermopathic medicine of treatment, the dermopathic emulsifiable paste of especially a kind of treatment (have another name called and be health skin spirit emulsifiable paste).
(2) background technology: present dermatosis sickness rate height, of a great variety, be born in body surface because of its pilosity, not only make the patient suffer the misery of disease itself, and hinder outward appearance and appearance, brought very big worry to the patient.Improving constantly along with living standards of the people in recent years, seek medical advice and demand strengthens day by day to dermopathic, treat dermopathic various ointment thereupon, emulsifiable paste market is raised variety various, daktarin as Xi'an Yang Sen, military medicine institute research inspire confidence in the fine jade emulsifiable paste, three nine-day periods after the winter solstice PIYANPING emulsifiable paste of China Shenzhen three nine-day periods after the winter solstice Pharmaceutical limited company production, these medicines all are famous brand and the choice drugs in clinical skin treating, but these medicines come with some shortcomings, in dermopathic clinical treatment: (1) daktarin, this medicine is only limited to fungal infection, as tinea pedis, tinea cruris, the tinea manuum, tinea corporis, tinea versicolor, tinea capitis, tinea unguium, and treatment time long (2 to 5 week), tinea unguium just can be seen curative effect about 7 months.Simultaneously, local dark the wiping has greasy feeling.(2) inspire confidence in this medicine of its emulsifiable paste and also be only limited to fungal infection.As: tinea corporis, tinea cruris, dissipating rashes tinea etc., clinical verification treatment time long (2 to 4 week), the part is obvious because of the medicine irritant reaction.(3) three nine-day periods after the winter solstice Piyanping ointment: this medicine only is used for eczema, dermatitis, skin itching disease.Above several drugs all has limitation in clinical treatment, dermatosis sickness rate in the crowd is higher, and can have the various skin disease to exist simultaneously on a human body, and certain difficulty is arranged in the treatment, and several ointment are used simultaneously, also make troubles to patient.
(3) summary of the invention: the dermopathic emulsifiable paste of a kind of treatment provided by the present invention, technical problem to be solved was the expansion therapeutic domain, improves clinical cure rate, shortened treatment time (having another name called health skin spirit emulsifiable paste).
Technical scheme of the present invention is: this medicine is to be made by following component, (consumption is a weight portion)
Stearic acid 1.5 white oils 2.5
Triethanolamine 0.4 glycerol 1
Ethyl hydroxybenzoate 0.01 Borax 0.01
Distilled water 3-7 vitaminB10 .01
Vitamin B6 0.01-0.05 griseofulvin 0.1-0.6
Optimum weight (part) proportioning of preparation medicine of the present invention is:
Stearic acid 1.5 white oils 2.5
Triethanolamine 0.4 glycerol 1
Ethyl hydroxybenzoate 0.01 Borax 0.01
Distilled water 4.6 vitaminB10 .02
Vitamin B6 0.02 griseofulvin 0.2
Its production method is:
The first step: stearic acid, white oil, triethanolamine, glycerol, ethyl hydroxybenzoate, Borax, distilled water are reconciled into substrate by a certain percentage.
Second step: with vitamin B
1, vitamin B
6, griseofulvin and other medicines add simultaneously and are in harmonious proportion in the good substrate furnishing emulsifiable paste in container.
The 3rd step: packing.
Against existing technologies, the invention has the beneficial effects as follows:
Its pharmaceutical properties is: it has, and effect is fast, and penetration power is strong, comes into force rapidly, and treatment time is short, acute (5 to 7 days), chronic (3 to 5 week), side effect is little, and skin is had no stimulation, and old man's infant, anemia of pregnant woman all can use, medicine is stable, pollution clothes not, easily eccysis.
Therapeutic domain: 1. tinea pedis, tinea corporis, tinea cruris, tinea versicolor, lichen planus, acute and chronic psoriasis, neurodermatitis.2. various types of eczemas: the facial eczema of infant, anal eczema, perineal position eczema.3. contact dermatitis, drug eruption, solar dermatitis, seborrheic dermatitis, urticaria, skin itching disease.4. comedo (facial acne), rosacea etc.
Usage: clean affected part every day 2-3 time, the ointment that takes a morsel is evenly smeared, up to whole absorptions.
Through clinical experiment.1. treat 560 examples such as tinea pedis, tinea corporis, tinea cruris, tinea capitis, tinea versicolor, effective percentage 98%, cure rate 93%.2. treat neurodermatitis, psoriasis 240 examples, effective percentage 92%.3. treat various types of eczema 450 examples, effective percentage 100%, cure rate 98%.4. treat contact dermatitis, drug eruption, solar dermatitis, dryness dermatitis 260 examples, effective percentage 100%, cure rate 96%.5. treat comedo (facial acne), rosacea 180 examples, effective percentage 93%, cure rate 80%.
(4) description of drawings: do not have.
(5) specific embodiment: take by weighing raw material (kilogram) by following proportioning
Stearic acid 1.5 white oils 2.5
Triethanolamine 0.4 glycerol 1
Ethyl hydroxybenzoate 0.01 Borax 0.01
Distilled water 4.6 vitaminB10 .02
Vitamin B6 0.02 griseofulvin 0.2
Its production method is as follows:
The first step: medicines such as stearic acid, white oil, triethanolamine, glycerol, ethyl hydroxybenzoate, Borax, distilled water are reconciled into substrate.
Second step: vitamin B1, vitamin B6, griseofulvin and other medicines are added in the substrate simultaneously furnishing emulsifiable paste in container.
The 3rd step: packing gets final product.
Claims (5)
1, the dermopathic emulsifiable paste of a kind of treatment (having another name called health skin spirit emulsifiable paste); It is characterized in that: the medicament of making by following materials of weight proportions:
Stearic acid 1.5 white oils 2.5
Triethanolamine 0.4 glycerol 1
Ethyl hydroxybenzoate 0.01 Borax 0.01
Distilled water 3-7 vitaminB10 .01-0.05
Vitamin B6 0.01-0.05 griseofulvin 0.1-0.6
2, the dermopathic emulsifiable paste of a kind of treatment according to claim 1 (having another name called health skin spirit emulsifiable paste), it is characterized in that: wherein the weight proportion of each raw material is:
Stearic acid 1.5 white oils 2.5
Triethanolamine 0.4 glycerol 1
Ethyl hydroxybenzoate 0.01 Borax 0.01
Distilled water 4.6 vitaminB10 .02
Vitamin B6 0.02 griseofulvin 0.2
3, the dermopathic emulsifiable paste of a kind of treatment according to claim 1 (having another name called health skin spirit emulsifiable paste), it is characterized in that: said medicament is a said dosage form on any pharmaceutics.
4, according to claim 1 or the dermopathic emulsifiable paste of 3 described a kind of treatments (having another name called health skin spirit emulsifiable paste), it is characterized in that: said medicament is an emulsifiable paste.
5, according to claim 1 or the dermopathic emulsifiable paste of 4 described a kind of treatments (having another name called health skin spirit emulsifiable paste), it is characterized in that: preparation method is, earlier with stearic acid, white oil, triethanolamine, glycerol, ethyl hydroxybenzoate, medicine such as Borax, distilled water reconciles into substrate, add vitamin B1, vitamin B6, griseofulvin and other medicines in the substrate simultaneously then, furnishing emulsifiable paste in container, packing gets final product at last.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01132766 CN1338257A (en) | 2001-09-07 | 2001-09-07 | A cream for treating dermatoses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01132766 CN1338257A (en) | 2001-09-07 | 2001-09-07 | A cream for treating dermatoses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1338257A true CN1338257A (en) | 2002-03-06 |
Family
ID=4671567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01132766 Pending CN1338257A (en) | 2001-09-07 | 2001-09-07 | A cream for treating dermatoses |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1338257A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112569272A (en) * | 2020-12-31 | 2021-03-30 | 河南金丝指生物科技有限公司 | Traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and preparation method thereof |
-
2001
- 2001-09-07 CN CN 01132766 patent/CN1338257A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112569272A (en) * | 2020-12-31 | 2021-03-30 | 河南金丝指生物科技有限公司 | Traditional Chinese medicine composition with functions of diminishing inflammation, relieving pain and removing acne and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |