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CN111315407A - 一种广谱抗流感疫苗免疫原及其应用 - Google Patents

一种广谱抗流感疫苗免疫原及其应用 Download PDF

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CN111315407A
CN111315407A CN201880001963.XA CN201880001963A CN111315407A CN 111315407 A CN111315407 A CN 111315407A CN 201880001963 A CN201880001963 A CN 201880001963A CN 111315407 A CN111315407 A CN 111315407A
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vaccine
influenza
recombinant
immunogen
vector
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CN111315407B (zh
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徐建青
张晓燕
谢辛慈
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SHANGHAI PUBLIC HEALTH CLINICAL CENTER
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Abstract

本发明提供了一种新型的抗流感免疫原，其序列包括如SEQ ID No:1和SEQ ID No:2所示的氨基酸序列，或其免疫原性片段，或其组合。此外，本发明还提供了采用该免疫原的重组载体疫苗及其免疫方法在抗流感疫苗中的应用。通过表达该新型流感免疫原的多种载体疫苗序贯应用，并采用全身系统免疫和局部免疫的组合，在呼吸道局部诱导高水平T细胞免疫应答，可对多种流感病毒感染产生广谱性保护作用。

Description

PCT国内申请，说明书已公开。

Claims (27)

  1. PCT国内申请，权利要求书已公开。
CN201880001963.XA 2018-09-11 2018-09-11 一种广谱抗流感疫苗免疫原及其应用 Active CN111315407B (zh)

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EP (2) EP3851120A4 (zh)
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AU (1) AU2020421142A1 (zh)
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CN113024640A (zh) * 2020-12-28 2021-06-25 广州中医药大学顺德医院(佛山市顺德区中医院) 一种基于新冠病毒rbd与ace2受体结合结构域筛选的表位肽抗原检测中和抗体试剂盒
CN113171449A (zh) * 2021-04-27 2021-07-27 青岛农业大学 一种甲型流感病毒通用dna疫苗及其构建方法
CN116947982A (zh) * 2023-07-12 2023-10-27 吉林大学 三条优势表位肽序列及其在流感病毒疫苗的应用
CN117430664A (zh) * 2023-10-24 2024-01-23 暨南大学附属第六医院(东莞市东部中心医院) 一种甲型流感病毒t细胞抗原表位肽及其应用

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CN111601885B (zh) 2017-11-30 2025-01-07 武田疫苗股份有限公司 用于将寨卡病毒灭活的方法和相关方法
CA3153528A1 (en) * 2019-09-16 2021-03-25 Dalu CHEN Methods of blocking asfv infection through interruption of cellular receptors
CA3178834A1 (en) * 2020-04-14 2021-10-21 The Regents Of The University Of California Large sequence pan-coronavirus vaccine compositions
CN113117069B (zh) * 2020-05-29 2022-09-30 北京启辰生生物科技有限公司 抗新型冠状病毒疫苗及其制备方法
US20240252619A1 (en) * 2021-05-21 2024-08-01 The Regents Of The University Of California Coronavirus Constructs and Vaccines
WO2023028327A1 (en) * 2021-08-27 2023-03-02 Cornell University Multivalent viral particles
CN113633764B (zh) * 2021-09-02 2024-05-14 中国食品药品检定研究院 一种含佐剂的新冠dna疫苗
CN116068192A (zh) * 2022-01-24 2023-05-05 中国农业大学 一种检测非洲猪瘟病毒抗体的ELISA检测试剂盒以及protein L的应用
CN119300843A (zh) * 2022-02-23 2025-01-10 定凯生物科技有限公司 表达嵌合抗原受体的经修饰的不变自然杀伤t细胞及其用途
EP4587054A2 (en) * 2022-09-13 2025-07-23 Oregon Health and Science University Universal t cell-based, cmv-vectored vaccine for influenza
WO2024197249A1 (en) * 2023-03-23 2024-09-26 The Penn State Research Foundation Improved yield of paramyxovirus-like particles through use of altered viral matrix proteins
WO2025064936A1 (en) * 2023-09-22 2025-03-27 Astrid Pharma Corp. Composition for prophylaxis and/or treatment of infection and use thereof
CN117778430B (zh) * 2024-01-25 2025-07-01 福建农林大学 稻瘟病菌MoPCP1基因及其应用
CN118255849B (zh) * 2024-02-06 2024-10-01 中山大学·深圳 一种流感病毒通用疫苗及其制备方法与应用

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