CN1112024A - Method for preparing medical biologic film - Google Patents
Method for preparing medical biologic film Download PDFInfo
- Publication number
- CN1112024A CN1112024A CN 95104422 CN95104422A CN1112024A CN 1112024 A CN1112024 A CN 1112024A CN 95104422 CN95104422 CN 95104422 CN 95104422 A CN95104422 A CN 95104422A CN 1112024 A CN1112024 A CN 1112024A
- Authority
- CN
- China
- Prior art keywords
- solution
- film
- mixings
- concentration
- gel slurry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000499 gel Substances 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 claims abstract description 5
- 239000008273 gelatin Substances 0.000 claims abstract description 5
- 229920000159 gelatin Polymers 0.000 claims abstract description 5
- 235000019322 gelatine Nutrition 0.000 claims abstract description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 14
- 239000010408 film Substances 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 229920001661 Chitosan Polymers 0.000 claims description 11
- 239000002002 slurry Substances 0.000 claims description 10
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 239000010409 thin film Substances 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 229960000583 acetic acid Drugs 0.000 claims description 3
- 230000000845 anti-microbial effect Effects 0.000 claims description 3
- 239000012362 glacial acetic acid Substances 0.000 claims description 3
- -1 polyoxyethylene Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 239000000243 solution Substances 0.000 abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract description 2
- 229920002101 Chitin Polymers 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 229940124350 antibacterial drug Drugs 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The medical biofilm is prepared through mixing chitin amine solution, gelatin solution, aqueous solution of polyoxyethene and glycerin to form gel size as matrix, addition of Chinese-medicinal liquid and antibacterial drug, spreading on smooth plane and naturally drying, and features low cost, good filming nature, elasticity, softness, and penetrativity, and antibacterial and antiphlogistic function. It may be used to cover wound to promote healing.
Description
The present invention relates to a kind of preparation of medical material, particularly a kind of preparation method of medical biologic film.
Medical domain is extensive use of products such as cellulose derivative, polyoxyethylene, acrylic acid, resin when the protection wound surface at present; great majority are synthetic or semi-synthetic macromolecular compound, and human body is interior, nature lacks derivant or the enzyme that decomposes these polymer substances.So effect in this respect such as natural polymer such as chitosan more and more is subject to people's attention.
The purpose of this invention is to provide that a kind of preparation technology is simple, cost is low and the preparation method of the medical biologic film of better clinical effectiveness is arranged.
Purpose of the present invention realizes with following technical scheme: it is in the glacial acetic acid solution of 1-2% that the chitosan that at first 10-50 is restrained in the described method is dissolved in 1 liter of concentration, getting concentration again is 2-5%(W/V) gelatin solution, 2-10%(W/V) polyoxyethylene alcohol-water solution, glycerol, above-mentioned four kinds of solution were according to volume ratio 40: 20: 15: 6 abundant stirring and evenly mixings, make the chitosan gel slurry as substrate; When Chinese medicine Pollen Typhae 100 gram is added water 1000ml and decocts medicine juice and be concentrated into 500ml, use the multilamellar filtered through gauze, take concoction, with chitosan gel slurry and Pollen Typhae medicine juice mixing by volume, in room temperature 20-25 ℃ sterilizing room, sprawl on flat board, becoming little yellow thickness through 48-72 hour natural drying is the thin film of 0.2-0.6mm, stand-by after low temperature, vacuum, sterilization.
Pollen Typhae medicine juice usable concentration in the described method is 10-20%(W/V) the anti-microbial type medicine, 8: 1 by volume abundant mixings of chitosan gel slurry and anti-microbial type drug solution spread on the flat board in room temperature is 20-25 ℃ sterilizing room, become translucent, the milky thin film of thickness 0.2-0.6mm through 48-72 hour natural drying, stand-by after low temperature, vacuum sterilization.
The used chitosan of the present invention is a kind of ocean high molecular polysaccharide biomaterial, is the primary raw material of present artificial epithelium, has film property, breathability.
Have elasticity, compression resistance during the polyvinyl alcohol film forming, pasting property is relatively good.
Glycerol is a kind of oily matter, can prevent sclerosis when film forming.Medical gelatin can impel the slurry film forming, increases toughness.
That the Chinese medicine Pollen Typhae has is antibiotic, antiinflammatory, effect.
The present invention can be covered in skin wound, mucosa, large tracts of land shallow; nontoxic to human body; the protection wound surface is avoided environmental stimuli and pollution; have sterilization, antibacterial, promote the healing of wound surface epithelium, be convenient to clinical observation; alleviating the patient changes dressings and waits bitterly for characteristics; preparation method of the present invention is simple, cost is low, and film property, resilient flexibility are good, and higher medical value is arranged.
Embodiment 1: get 30 the gram chitosan be dissolved in 2%(W/V) glacial acetic acid aqueous solution in, fully stir till the dissolving fully, aqueous gelatin solution 2%(W/V), polyvinyl alcohol water solution 5%(W/V), glycerol, above-mentioned four kinds of solution 40: 20: 15 by volume: 6 mixings, make gel slurry, get the antimicrobial drug metronidazole solution of concentration 20% for substrate, gel slurry and metronidazole solution were by 8: 1 mixings, in sterilizing room, be laid on the flat board, through 56 hours natural dryings, desirable film, thin film were translucent, milky in the time of 20 ℃.
Embodiment 2: when Chinese medicine Pollen Typhae 100 gram is added water 1000ml and decocts medicine juice and be concentrated into 500ml, use the multilamellar filtered through gauze, it is stand-by to take concoction, get gel slurry and by volume 8: 1 mixings of Pollen Typhae medicine juice among the embodiment 1, in sterilizing room, be laid on flat board, through 50 hours natural dryings, get film through low temperature in the time of 25 ℃, the vacuum stand-by film color of sterilizing is a milk yellow.
Claims (2)
1, a kind of preparation method of medical biologic film, it is characterized in that, at first fully to be dissolved in 1 liter of concentration be in the glacial acetic acid solution of 1-2% to the chitosan of 10-50 gram, get the gelatin solution that concentration is 2-5% again, the polyoxyethylene alcohol-water solution of 2-10%, glycerol, with above-mentioned four kinds of solution according to volume ratio 40: 20: 15: 6 abundant stirring and evenly mixings, make the chitosan gel slurry as substrate, when Chinese medicine Pollen Typhae 100 gram is added water 1000ml and decocts medicine juice and be concentrated into 500ml, use the multilamellar filtered through gauze, take concoction, with chitosan gel slurry and 8: 1 by volume mixings of Pollen Typhae medicine juice, sprawl on flat board in room temperature 20-25 ℃ sterilizing room, becoming little yellow thickness through 48-72 hour natural drying is the thin film of 0.2-0.6mm, through low temperature, stand-by behind the vacuum sterilization.
2, the preparation method of medical biologic film as claimed in claim 1, it is characterized in that: as the chitosan gel slurry can be 8: 1 by volume abundant mixings of 10-20% anti-microbial type medicine with concentration also, in being 20-25 ℃ sterilizing room, room temperature spreads on the flat board, become thickness 0.2-0.6mm translucent through 48-72 hour natural drying, milky thin film, stand-by after low temperature, vacuum sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95104422 CN1037818C (en) | 1995-05-01 | 1995-05-01 | Preparation method of medical biological film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95104422 CN1037818C (en) | 1995-05-01 | 1995-05-01 | Preparation method of medical biological film |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1112024A true CN1112024A (en) | 1995-11-22 |
| CN1037818C CN1037818C (en) | 1998-03-25 |
Family
ID=5075123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95104422 Expired - Fee Related CN1037818C (en) | 1995-05-01 | 1995-05-01 | Preparation method of medical biological film |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1037818C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067281C (en) * | 1997-05-22 | 2001-06-20 | 吴湘君 | Cohesive and hydrophilic gel for medical use, and method for preparing same |
| CN1118301C (en) * | 1996-06-28 | 2003-08-20 | 庄臣及庄臣医药有限公司 | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
| CN1328316C (en) * | 2004-03-26 | 2007-07-25 | 杨晓霞 | Prepn process of degradable bioactive film |
| CN1333131C (en) * | 2005-08-03 | 2007-08-22 | 高明宝 | Antibacterial mite-removing fiber product and its manufacturing method |
| CN100411651C (en) * | 2005-06-17 | 2008-08-20 | 吴湘君 | Medical gel and its preparing method and device |
-
1995
- 1995-05-01 CN CN 95104422 patent/CN1037818C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1118301C (en) * | 1996-06-28 | 2003-08-20 | 庄臣及庄臣医药有限公司 | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
| CN1067281C (en) * | 1997-05-22 | 2001-06-20 | 吴湘君 | Cohesive and hydrophilic gel for medical use, and method for preparing same |
| CN1328316C (en) * | 2004-03-26 | 2007-07-25 | 杨晓霞 | Prepn process of degradable bioactive film |
| CN100411651C (en) * | 2005-06-17 | 2008-08-20 | 吴湘君 | Medical gel and its preparing method and device |
| CN1333131C (en) * | 2005-08-03 | 2007-08-22 | 高明宝 | Antibacterial mite-removing fiber product and its manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1037818C (en) | 1998-03-25 |
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| C14 | Grant of patent or utility model | ||
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