CN1317042C - Biologic external application medicine for curing wound - Google Patents
Biologic external application medicine for curing wound Download PDFInfo
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- CN1317042C CN1317042C CNB2005100571579A CN200510057157A CN1317042C CN 1317042 C CN1317042 C CN 1317042C CN B2005100571579 A CNB2005100571579 A CN B2005100571579A CN 200510057157 A CN200510057157 A CN 200510057157A CN 1317042 C CN1317042 C CN 1317042C
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Abstract
The present invention relates to a biological externally applied medicine for the medical care of wounds. The present invention is characterized in that the medicine is prepared from 18 to 45 parts by weight of isobutyl chitosan as a substrate, and raw medicinal materials containing 9 to 27 parts by weight of ofloxacin, 18 to 37 parts by weight of lidocaine and / or 18 to 45 parts by weight of tranexamic acid; the medicine prepared by the proportion and acetic acid-sodium acetate solution whose pH value is 6 or distilled water are prepared into the solution containing 1.5 to 4% of the medicine, namely the externally applied medicine. The present invention has good functions of stopping bleeding, relieving inflammation, killing pain and promoting healing on wounds, and the present invention can be prepared into sprays or pastes.
Description
(1), affiliated technical field
The present invention relates to a kind of topical drug of health care, particularly a kind of application compress that are used for skin trauma.
(2), technical background
In the human body skin damnification that treatment is lost in a organized way, the effect of medical dressing is very important, uses very extensive.And in the medical dressing of a great variety; biological medicine carrying dressing is because its particular performances; as the favorable tissue compatibility and degradability, safety and low toxicity, in the protection wound surface, can also treat wound effectively, promote tissue repair etc. and people's attention extremely.Chitosan is the chitin deacetylase based products.Chitin is the important component of arthropod shell, also is present in the cell wall of fungus and algae.Because its rich natural resource and unique biological activity; as fabulous biocompatibility and degradability; good film property; certain antibiotic and anthemorrhagic performance; safety and low toxicity etc.; be described as the biological material of 21 century, its application has spreaded all over every field such as industry, agricultural, national defence, medical science, environmental conservation, especially more demonstrates application prospects and potential value at biomedical sector.As with the chitosan be the biological dressing of raw material production at histocompatibility, permeability, draw and demonstrate distinctive advantage aspect intensity, the wound healing promoting; And many studies show that chitosan as pharmaceutical carrier by skin and mucosa delivery the time, can reach slow release, lasting, improve the effect of local drug concentration.
Disclose the patent of invention that a kind of name is called " prescription of biologic dressing for burns and processing technique " in CN1079909A, it is the biologic dressing for burns that is prepared from chitosan, glycerol, water, antibiotic property medicine norfloxacin and porous backing material.The characteristics of this dressing are to have strengthened its fungistatic effect, and do not have to strengthen hemostasis to wound, analgesia, short therapeutical effect such as more.
The patent of invention that a kind of name is called " preparation of chitosan iodine wound dressing " is disclosed in CN1115254A, it is to be raw material with the chitosan, make the chitosan non-woven fabrics, on its non-woven fabrics one side, apply chitosan film, again this chitosan non-woven membrane is immersed in the iodine solution that contains glycerol absorption medicine iodine.The same with above-mentioned patent, the characteristics of this patent are that fungistatic effect is good, but to other therapeutical effect of wound then relatively a little less than.
The patent of invention that a kind of name is called " a kind of biological medicine film and system method thereof " is disclosed in CN1411805A, it is by making rubber cement respectively with chitosan, gelatin, and then the suspension made by Borneolum Syntheticum, Musca domestica larva, Galla Chinensis Chinese medicines such as (stir-frys) of compatibility and forming, it is mainly to skin ulcer, especially oral ulcer has preferably short more effect, but obvious inadequately to functions such as the hemostasis of wound, analgesias
The patent of invention that a kind of name is called " prescription of chitosan Chinese medicine compound herbal membrane " is disclosed in CN1393230A, it is to be combined the chitosan Chinese medicine compound herbal membrane made from chitosan by Radix Arnebiae (Radix Lithospermi) 15%, Radix Angelicae Sinensis 15%, the Radix Angelicae Dahuricae 10%, Sanguis Draxonis 10%, 10% 5 kind of Chinese medicine ingredients of Margarita.Its main effect remains the healing that promotes ulcer skin, and is not suitable for antiinflammatory, analgesia and the hemostasis of acute wound surface.
Therefore, see with the chitosan to be that the medicine carrying dressing of substrate still exists following deficiency with regard to present present Research:
1. dosage form is single.Because the water insoluble and common organic solvents of chitosan molecule is only soluble in acid solution, makes the change of its dressing dosage form be subjected to great restriction.Be outside the dressing of substrate divided by chitosan non-woven fabrics and chitosan coat gauze at present, it is more convenient also not have other use, can be used for the chitosan dressing of arbitrary shape and big minor cut or wound such as the research report of unguentum, spray etc.
2. function singleness.Above-mentioned several patents only is to have strengthened the single antibacterial or promoting healing function of chitosan, and to the hemostasis of wound surface relative with the analgesic function a little less than, up to the present do not have as yet function comparatively comprehensively composite biological dressing come out.
(3), summary of the invention
Purpose of the present invention just provides a kind of biological drug of topical application that wound is cured that is used for antiinflammatory and promoting healing function,
The objective of the invention is to realize by such technical scheme, it is to be substrate by isobutyl-chitosan, and be equipped with crude drug and form, crude drug is an ofloxacin, wherein, the proportioning of isobutyl-chitosan and ofloxacin parts by weight is: 18～45 parts of isobutyl-chitosans, 9～27 parts of ofloxacins; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 1.5%～4% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
It is substrate that the present invention at first selects the soluble derivative-isobutyl-chitosan of chitosan after chemistry changes structure.At " Chinese biochemical drug magazine " (2002,23 (3), 124) delivered the article that name is called " preparation of isobutyl-chitosan and biodegradation Journal of Sex Research " in, at " Chinese marine drug " (2003,4,30) delivered the article that name is called " the biological safety evaluation of water solublity isobutyl-chitosan " in, these two pieces of articles have clearly illustrated that not only safety non-toxic of this derivant of isobutyl-chitosan, and biocompatibility similar to chitosan and more good degradation property are arranged, and condition has been created in the development that its good water dissolution performance is the chitosan dressing novel form; In order to improve the antibacterial and anti-inflammation functions of the drug of topical application, the present invention has selected has a broad antifungal spectrum, and gram positive bacteria and negative bacterium are all had powerful antibacterial action, skin soft-tissue infection is had the ofloxacin of good curative effect; The spray dressing that utilizes this prescription to make can form one deck waterproof and breathable, whippy location medicine film at wound surface, both can prevent the intrusion of antibacterial without gauze to wound, can be used as pharmaceutical carrier again and by mucosa delivery the time, reach slow release, lasting, improve the effect of local drug concentration, thereby reach the treatment of wound being carried out anti-inflammation, stimulate the growth of new raw meat tooth under film, the purpose of accelerating wound healing.
The preparation method of the above-mentioned drug of topical application is: it is that the elimination insoluble matter obtains a transparent glue in 6 the acetic acid-sodium acetate solution or distilled water that 18～45 parts isobutyl-chitosans are dissolved in pH; In addition 9～27 parts ofloxacin also is dissolved in little acetic acid-sodium acetate solution or the distilled water a medicinal liquid; Then medicinal liquid is mixed with transparent glue, is mixed with together with distilled water again that to contain concentration be 1.5%～4%, the drug of topical application.
Owing to adopted technique scheme, the present invention has good hemostasis, antiinflammatory, analgesia, promoting healing function to traumatic wounds, and it can be prepared to spray or unguentum.
(4), the specific embodiment
The invention will be further described below in conjunction with embodiment:
The present invention is to be substrate by isobutyl-chitosan, and is equipped with crude drug and forms, and crude drug is an ofloxacin, and wherein, the parts by weight proportioning of isobutyl-chitosan and ofloxacin is: 18～45 parts of isobutyl-chitosans, 9～27 parts of ofloxacins; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 1.5%～4% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
Be preferably: the parts by weight proportioning of isobutyl-chitosan is 27 parts, and the parts by weight of ofloxacin are 18 parts; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 2.5% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.This is one of preferred forms.
The preparation method of the above-mentioned drug of topical application is: it is that the elimination insoluble matter obtains a transparent glue in 6 the acetic acid-sodium acetate solution or distilled water that 27 parts of isobutyl-chitosans are dissolved in pH; In addition 18 parts of ofloxacins also are dissolved in and get a medicinal liquid in little acetic acid-sodium acetate solution or the distilled water, then medicinal liquid is mixed with transparent glue, is mixed with together with distilled water again that to contain concentration be 2.5%, the drug of topical application, wherein: contain isobutyl-chitosan 1.5%, ofloxacin 1%.
In the above-mentioned drug of topical application, crude drug can also contain lignocaine except that ofloxacin, and wherein, the parts by weight proportioning of lignocaine is 18～37 parts; The medicine that described proportioning is made is that 6 acetic acid-sodium acetate solution or distilled water are made into that to contain concentration be 2.5%～6% with pH, the drug of topical application.Selecting lignocaine mainly is to be used for surface local anesthesia, to increase the analgesic activity of dressing.
Be preferably: the parts by weight proportioning of each component is: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins, 27 parts of lignocaine; Is that 6 acetic acid-sodium acetate solution or distilled water are made into that to contain concentration be 4% with the medicine of making of described proportioning with pH, the drug of topical application.This is one of preferred forms.
The preparation method of the above-mentioned drug of topical application is: it is that the elimination insoluble matter obtains a transparent glue in 6 the acetic acid-sodium acetate solution or distilled water that 27 parts of isobutyl-chitosans are dissolved in pH; In addition 18 parts of ofloxacins, 27 parts of lignocaine also are dissolved in and get a medicinal liquid in little acetic acid-sodium acetate solution or the distilled water, then medicinal liquid is mixed with transparent glue, follow distilled water to be mixed with together again containing concentration is 4%, the drug of topical application, wherein: contain isobutyl-chitosan 1.5%, ofloxacin 1%, lignocaine 1.5%.
In the above-mentioned drug of topical application, crude drug can also contain tranexamic acid except that ofloxacin, and wherein, the parts by weight of tranexamic acid are 18～45 parts; The medicine that described proportioning is made is that 6 acetic acid-sodium acetate solution or distilled water are made into that to contain concentration be 2.5%～6.5% with pH, the drug of topical application.Selection can be used for the tranexamic acid of various hemorrhages, can strengthen the hemostatic function of the drug of topical application.
Be preferably: the parts by weight proportioning of each component is: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins, 37 parts of tranexamic acids; Is that 6 acetic acid-sodium acetate solution or distilled water are made into that to contain concentration be 4.5% with the medicine of making of described proportioning with pH, the drug of topical application.This is one of preferred forms.
The preparation method of the above-mentioned drug of topical application is: it is that the elimination insoluble matter obtains a transparent glue in 6 the acetic acid-sodium acetate solution or distilled water that 27 parts of isobutyl-chitosans are dissolved in pH; In addition 18 parts of ofloxacins, 37 parts of tranexamic acids also are dissolved in and get a medicinal liquid in little acetic acid-sodium acetate solution or the distilled water, then medicinal liquid is mixed with transparent glue, follow distilled water to be mixed with together again containing concentration is 4.5%, the drug of topical application, wherein: contain isobutyl-chitosan 1.5%, ofloxacin 1%, tranexamic acid 2%.
In the above-mentioned drug of topical application, crude drug also contains lignocaine in the crude drug except that ofloxacin and tranexamic acid, and wherein, the parts by weight of lignocaine are 18～37 parts; The medicine that described proportioning is made is that 6 acetic acid-sodium acetate solution or distilled water are made into that to contain concentration be 3.5%～8.5% with pH, the drug of topical application.Can make the present invention that traumatic wounds is had good hemostasis, antiinflammatory, analgesia, promoting healing function like this.
Be preferably: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins, 27 parts of lignocaine, 37 parts of tranexamic acids; Is that 6 acetic acid-sodium acetate solution or distilled water are made into that to contain concentration be 6% with the medicine of making of described proportioning with pH, the drug of topical application.
The preparation method of the above-mentioned drug of topical application is: it is that the elimination insoluble matter obtains a transparent glue in 6 the acetic acid-sodium acetate solution or distilled water that 27 parts of isobutyl-chitosans are dissolved in pH; In addition 18 parts of ofloxacins, 27 parts of lignocaine, 37 parts of tranexamic acids also are dissolved in and get a medicinal liquid in little acetic acid-sodium acetate solution or the distilled water, then medicinal liquid is mixed with transparent glue, follow distilled water to be mixed with together again containing concentration is 6%, the drug of topical application, wherein: contain isobutyl-chitosan 1.5%, ofloxacin 1%, lignocaine 1.5%, tranexamic acid 2%.
The invention will be further described below in conjunction with the test example: in four following test examples, test material all is: isobutyl-chitosan is synthetic by this laboratory, and its viscosity-average molecular weight is 1.31 * 105, and intrinsic viscosity is 221ml/g, deacetylation is 42.5%, and substitution value is 50.9%; Ofloxacin is provided by Zhejiang Yongning Pharmaceutical Factory; Lignocaine is provided by Shanghai Fosun Zhaohui Pharmaceutical Co., Ltd.; Tranexamic acid is pacified pharmaceutcal corporation, Ltd for a long time by Wuhan to be provided.Preparation method all is: it is that the elimination insoluble matter obtains a transparent glue in 6 the acetic acid-sodium acetate solution or distilled water that 27 gram isobutyl-chitosans are dissolved in pH; In addition 18 gram ofloxacins, 27 gram lignocaine, 37 gram tranexamic acids also are dissolved in and get a medicinal liquid in little acetic acid-sodium acetate solution or the distilled water, then medicinal liquid is mixed with transparent glue, follow distilled water to be mixed with together again containing concentration is 6%, the drug of topical application, wherein: contain isobutyl-chitosan 1.5%, ofloxacin 1%, lignocaine 1.5%, tranexamic acid 2%.
[test example 1] the present invention is to the anastalsis of rabbit hepar damnification
Test method:
6 of new zealand white rabbits, male and female have both, and body weight is 2.0-2.5kg, behind the anesthetized animal, open abdomen, the patient helps lobe of the liver with left hand, right hand scissors hold is cut off lobe of the liver edge part tissue, makes it hemorrhage, the drug of topical application is sprayed on organizes on the cut then, and pick up counting, till organizing cut no longer hemorrhage, record blood coagulation time (s) is the medication group, in kind but not administration, allow and hemorrhagely solidify voluntarily, record blood coagulation time (s) is matched group.Every rabbit is cooked matched group with two lobe of the liver, and two lobe of the liver are done the medication group.
The result shows: the average bleeding stopping period of medication group is 55.6 ± 7.4 seconds, and matched group is 147.9 ± 49.9 seconds, and two groups of differences have the meaning (p＜0.01) of highly significant.(seeing Table 1)
The hemostatic effect of table 1 drug of topical application
| Observation index | The medication group | Matched group |
| Wound area (cm2) | 2.71×0.49 | 2.67×0.49 |
| Bleeding stopping period (s) | 55.6±7.4 | 147.9±49.9 |
[test example 2] the present invention is to the topical pain relief effect of white mice
Test method:
14 of Kunming kind white mice, male and female have both, body weight 18-22g, adopt hot plate method to investigate the analgesic activity of prescription, be about to an aluminium sheet by thermostatical circulating water temperature control to 55 ℃, observe and record is put into white mice to rise on the aluminium sheet to white mice and licks the sufficient time (s), be the preceding matched group of medication, not administration is licked sufficient white mice in 30 seconds, in its metapedes spraying drug of topical application, wait to do film forming, behind the 1.5h again repeated observation and write down administration after white mice is put into the time (s) of licking metapedes on the aluminium sheet to white mice, be experimental group after the medication.
The result shows: it is 19.57 ± 3.63 seconds that matched group (before the medication) white mice on average licks the sufficient time, and experimental group (after the administration) is 39.50 ± 7.98 seconds, and two groups of differences have highly significant meaning (p＜0.01).[test example 3] the present invention is to the short more effect of rat wound
Test method:
6 of rat, male and female have both, body weight 180-200g, adopt incision healing method in back to observe the more effect of urging of prescription, be about to rat anesthesia, cut dorsal body setae and sterilization tailing edge spinal column both sides, cut the whole bark (interval 2.0～3.0cm) that two diameters are about 2cm, right side wound spraying medicinal liquid, be the administration group, the left side allows its spontaneous remission, is matched group.Observe the CI of 1 all backs wound and measure the callus hydroxyproline content, it the results are shown in Table 2.
The result shows: all apparently higher than matched group, confirm that this drug of topical application has good short more effect by the hydroxyproline content of the visible administration group of table 2 and wound closure index.
The short more effect of table 2 drug of topical application
| Observation index | Matched group | The medication group |
| 1W CI (%) | 39.1±11.3 | 60.5±12.8 |
| Hydroxyproline (mg/g) | 17.7±4.9 | 60.5±5.4 |
The antibacterial and anti-inflammation functions of [test example 4] drug of topical application of the present invention
Test method:
48 of new zealand rabbits, male and female are regardless of, body weight 2-2.5kg, anesthesia back survey experiment fore-anus temperature (℃), get blood and therefrom get 20 μ L and survey leukocyte count/mL immediately by arteria auricularis, all the other blood are collected blood plasma tumor necrosis factor-alpha before the blood plasma experiment to be measured, blood plasma il-1 β after centrifugal.
Cut the rabbit dorsal body setae, cut the skin of a 30mm * 30mm in the center, back, just add a certain amount of normal saline with a certain amount of rabbit and be modulated into just muddled scratch mouth, cause the wound contamination model; Then in the treatment group contaminated wound spraying drug of topical application, be coated with normal saline at the contaminated wound of matched group.Observe treatment group and matched group different time phases (3,6,12,24,72h, 7d) behind coating the anus temperature (℃), leukocyte, blood plasma tumor necrosis factor-alpha, blood plasma il-1 β change, and observe local circumstance's (as having or not wound sepage, redness, inflammation, incrustation), simultaneously 6,12, put mutually during 24h add do the training of wound bacterium and detect 6,24,72, tumor necrosis factor-alpha, il-1 β, superoxide dismutase, malonaldehyde, the variation of myeloperoxidase (MPO) of muscular tissue around the 7d rabbit local wound.
The result is as follows:
1. two groups of T (anus temperature) and numeration of leukocyte:
Two groups of anus temperature begin to raise from 6h, reach the peak to 12h or 24h, maintain subsequently than high fever status number day, 7d does not return to normal level yet, and the body temperature of matched group (NS group) is wanted a little higher than experiment (treatment group), and especially two groups of differences of 24h have significance meaning (p＜0.05); Hinder back 24h, control animals body temperature is apparently higher than the medication group, and total trend is a little higher than medication group of body temperature of matched group; Medication group and matched group leukocyte change difference does not have significance meaning (seeing Table 3).
Table 3 medication group and matched group anus temperature (℃) and the numeration of leukocyte result (X ± S)
| The time phase (h) N | Matched group (NS group) | Treatment group (medication group) | ||
| The anus temperature (℃) | Leukocyte/mL | The anus temperature (℃) | Leukocyte/mL | |
| 0 30 | 38.4±0.7 | 321.1±193.9 | 38.5±0.7 | 335.3±194.9 |
| 3 30 | 38.4±1.2 | 389.4±210.8 | 38.1±1.0 | 381.6±175.1 |
| 6 30 | 39.3±1.2 | 336.9±242.7 | 39.2±1.2 | 371.1±244.3 |
| 12 18 | 40.1±0.4 | 432.3±439.4 | 39.9±0.5 | 317.2±260.5 |
| 24 18 | 40.1±0.4 | 336.3±235.5 | 39.6±0.4α | 329.2±285.4 |
| 48 18 | 39.9±0.4 | 466.9±284.1 | 39.6±0.3 | 470.9±168.3 |
| 72 12 | 39.6±0.4 | 353.9±170.4 | 39.5±0.3 | 255.3±78.2 |
| 7d 6 | 39.6±0.5 | 404.3±155.8 | 39.4±0.3 | 333.8±129.6 |
With the matched group ratio, α represents p＜0.05.
2. wound local circumstance and bacteria cultivation results
Experimental result shows that the red and swollen degree of medication group wound obviously is lighter than matched group, and incrustation is more Zao and complete than matched group, and no pus under 72h, the 7d medication group crust have the green meat blastogenesis long, and a large amount of pus are arranged under the matched group crust, and wound still has red and swollen phenomenon.In addition each the time put the wound antibacterial culturing mutually the result show that the matched group clump count is obviously more than the medication group.
3. the situation of change of index such as the blood plasma and the meromyarian histiocyte factor
Medication group and matched group relatively, each the time put the optical density value of blood plasma tumor necrosis factor-alpha, il-1 β and local muscle tissue tumor necrosis factor-alpha, il-1 β mutually optical density value and meromyarian organize malonaldehyde, myeloperoxidase (MPO), superoxide dismutase content difference not to have the significance meaning.
Claims (8)
1. one kind is used for the biological drug of topical application that wound is cured, it is characterized in that it is is substrate by isobutyl-chitosan, and be equipped with crude drug and form, crude drug is an ofloxacin, wherein, the parts by weight proportioning of isobutyl-chitosan and ofloxacin is: 18～45 parts of isobutyl-chitosans, 9～27 parts of ofloxacins; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 1.5%～4% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
2. the biological drug of topical application that is used for the wound treatment as claimed in claim 1, it is characterized in that: the parts by weight proportioning of isobutyl-chitosan and ofloxacin is: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 2.5% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
3. the biological drug of topical application that is used for the wound treatment as claimed in claim 1 or 2, it is characterized in that: also contain lignocaine in the crude drug, wherein the parts by weight proportioning of each component is: 18～45 parts of isobutyl-chitosans, 9～27 parts of ofloxacins, 18～37 parts of lignocaine; The medicine that described proportioning is made is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 2.5%～6% with distilled water or pH, the drug of topical application.
4. the biological drug of topical application that is used for the wound treatment as claimed in claim 3 is characterized in that the parts by weight proportioning of each component is: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins, 27 parts of lignocaine; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 4% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
5. the biological drug of topical application that is used for the wound treatment as claimed in claim 1 or 2, it is characterized in that: also contain tranexamic acid in the crude drug, wherein, the parts by weight of tranexamic acid are 18～45 parts; The medicine that described proportioning is made is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 2.5%～6.5% with distilled water or pH, the drug of topical application.
6. the biological drug of topical application that is used for the wound treatment as claimed in claim 5 is characterized in that the parts by weight proportioning of each component is: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins, 37 parts of tranexamic acids; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 4.5% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
7. the biological drug of topical application that is used for the wound treatment as claimed in claim 5, it is characterized in that: also contain lignocaine in the crude drug, wherein, the parts by weight of lignocaine are 18～37 parts; The medicine that described proportioning is made is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 3.5%～8.5% with distilled water or pH, the drug of topical application.
8. the biological drug of topical application that is used for the wound treatment as claimed in claim 7 is characterized in that the parts by weight proportioning of each component is: 27 parts of isobutyl-chitosans, 18 parts of ofloxacins, 27 parts of lignocaine, 37 parts of tranexamic acids; Is that acetic acid-sodium acetate solution of 6 is made into that to contain concentration be 6% with the medicine of making of described proportioning with distilled water or pH, the drug of topical application.
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| US9655840B2 (en) * | 2009-12-22 | 2017-05-23 | Rigshospitalet, Copenhagen University Hospital | Wound care products |
| CN101954117A (en) * | 2010-09-27 | 2011-01-26 | 中国人民解放军第三军医大学野战外科研究所 | Hemostatic bacteriostatic biological dressing and preparation method thereof |
| CN102671232B (en) * | 2012-05-18 | 2014-08-13 | 成都理工大学 | Tourmaline/chitosan hydrochloride compound spray-type aqueous dressing and preparation method thereof |
| CN107753937A (en) * | 2016-08-19 | 2018-03-06 | 昆明倍健生物科技有限公司 | A kind of wound disinfection agent and preparation method thereof |
| CN113425889B (en) * | 2021-06-25 | 2023-01-24 | 延安大学 | A kind of antibacterial hemostatic sponge and its preparation method and application |
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| CN1449748A (en) * | 2003-04-24 | 2003-10-22 | 王立强 | Dry powder drug microsphere preparation for lung inhalation and preparation method thereof |
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| CN1449748A (en) * | 2003-04-24 | 2003-10-22 | 王立强 | Dry powder drug microsphere preparation for lung inhalation and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 异丁基壳聚糖的制备与生物降解性研究 李东红，胡德耀，肖南，田昆仑，中国生化药物杂志，第23卷第3期 2002 * |
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| 水溶性异丁基壳聚糖的生物安全性评价 李东红，田昆仑，刘良明，肖南，胡德耀，中国海洋药物，第94期 2003;异丁基壳聚糖的制备与生物降解性研究 李东红，胡德耀，肖南，田昆仑，中国生化药物杂志，第23卷第3期 2002 * |
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