CN1328316C - Prepn process of degradable bioactive film - Google Patents
Prepn process of degradable bioactive film Download PDFInfo
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- CN1328316C CN1328316C CNB2004100214740A CN200410021474A CN1328316C CN 1328316 C CN1328316 C CN 1328316C CN B2004100214740 A CNB2004100214740 A CN B2004100214740A CN 200410021474 A CN200410021474 A CN 200410021474A CN 1328316 C CN1328316 C CN 1328316C
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Abstract
The present invention provides a preparation method for a bioactive degradable film. The preparation method solves the technical problems that polylactic acid and chitosan are usually used as raw materials for preparing a bioactive degradable polymer at present, import polylactic acid is adopted as most of the polylactic acid due to the fact that requirements for the synthetic conditions of the polylactic acid are high, and the price of the import polylactic acid is very high; a degradable film which is prepared from the polylactic acid has long degradable time in a body, and therefore, the degradable film is not usually used at home. The preparation method has the key point that gelatin is completely dissolved into a PBS solution to be prepared into 0.3 to 5% of solution; chitin is completely dissolved into a citric acid-phosphoric acid buffering solution to be prepared into 0.5 to 5% of solution; polyvinyl alcohol is dissolved into a double-distilled water to be prepared into 3 to 15% of solution, and is completely dissolved to be in the shape of colorless transparent gelatin; and after the gelatine solution, the chitin solution and the polyvinyl alcohol solution are taken to be completely mixed according to a proportion of 4 to 8:2 to 7:3 to 7, the mixed solution is coated on a glass board, and is naturally dried at room temperature to form the bioactive degradable film. The bioactive degradable film has the advantages that the bioactive degradable film has the ideal function of slowly releasing bioactive matter, and is rapidly degraded in a body.
Description
Technical field
The present invention relates to the preparation method of biological activity degradative membrane
Background technology
Biological degradation polyalcohol is a kind of organism compound of synthetic, in vivo degradable absorb, nontoxic, do not have and accumulate, better biocompatibility is arranged, now be widely used in absorbable suture, the slow-released carrier of medicine, Steel Plate For Fixation Of Fracture and retaining screw etc.Particularly pay close attention to for the people as the research of slow releasing carrier of medication.The effect of biodegradable polymer carrier in the controlled release drug delivery system, be to make medicine discharge medicine with zero order kinetics speed or other controlled rate, thereupon drug release totally, polymer carrier itself also just is degraded into small-molecule substance, and is absorbed by human body or get rid of external.Be generally used for the main polyester of polymer carrier and the monoamino-acid class of medicine controlled releasing, mainly be some chemical substance by structural modification or adopt the technology of pharmaceutics means to come the speed of control drug release, prolong drug action time.What research was more at present is to make forms such as microballoon, micro-capsule, tubular fibre, and pharmaceutical pack is rolled in wherein, passes through drug administration by injection.Make form research few of degradative membrane.
Make Biodegradable films and mainly be divided into two big classes, a class is to make Biodegradable films separately, does not add any medicine or active substance, and this film can be used as the mechanical barrier between the surgery damage tissue, prevention abdominal postoperative tissue adhesion; Also can be used as film guide tissue regeneration technology and use in Oral and Maxillofacial Surgery and orthopaedics, it creates a barrier environment, prevents connective tissue growth, guiding osteanagenesis, and it is damaged to repair osseous tissue.Another kind of is to prepare the degradative membrane that contains medicine or active substance, and this type of bibliographical information seldom.
What at present the raw material of preparation biological degradation polyalcohol was commonly used is poly(lactic acid) and chitosan, poly(lactic acid) synthetic conditional request is higher, adopts import mostly, costs an arm and a leg; Chronic by the degradative membrane degradation in vivo that poly(lactic acid) is made, so domestic use seldom.
Summary of the invention
The object of the present invention is to provide a kind of preparation method who contains the biological activity degradative membrane.Can avoid above-mentioned deficiency with the biological activity degradative membrane that this method is prepared.
The object of the present invention is achieved like this: be main raw material with the chitosan, add related substances simultaneously, prepare colorless and odorless, softness, translucent, have certain mechanical strength, certain elasticity and a flexible membranoid substance.Can be water-soluble, but wet tenacity is better, tensile property is good, is convenient to use in the operation.The eventual degradation product is that glucosamine is the material that human body exists, thereby good biocompatibility, has no side effect.
Preparation method of the present invention is:
1, gelatin is dissolved in the balanced salt solution PBS solution fully, is made into 0.3-5% solution.
2, chitosan is dissolved in citric acid-phosphoric acid buffer fully, is made into 0.5-5% solution.
3, polyvinyl alcohol is dissolved in the distilled water, is made into 3-15% solution, it is dissolved fully be water white glue.
4, get gelatin solution, chitosan solution, polyvinyl alcohol solution, these three kinds of solution are in 4-8: 2-7: after the 3-7 ratio is mixed fully, be layered on the sheet glass seasoning film forming under the room temperature.
The present invention compared with prior art has the effect of ideal slow releasing bioactivity material, and comparatively fast degraded in vivo.Concrete characteristics are:
1, containing biologically active substance in the degradative membrane, and preserve its activity, is the ideal carrier.
2, the non-chitosan one-component of Biodegradable films is made, and adds related substances slow release speed is accelerated, and improves degradation rate.The degradation in vivo time is about 35 days.
3, has ideal slowly-releasing rate as pharmaceutical carrier.
Guarantee under the prerequisite of the certain sustained release rate of this active substance that 4, add toughness, intensity and gloss that related substance increases film, wet tenacity is better in water, is convenient to use in operation.
Further specify the present invention below in conjunction with embodiment.
Embodiment
1, gelatin is dissolved in the balanced salt solution PBS solution fully, is made into 3% solution.
2, chitosan is dissolved in citric acid-phosphoric acid buffer fully, is made into 3% solution.
3, polyvinyl alcohol is dissolved in the distilled water, is made into 10% solution, it is dissolved fully be water white glue.
4, get gelatin solution, chitosan solution, polyvinyl alcohol solution, these three kinds of solution are layered on the sheet glass seasoning film forming under the room temperature after mixing fully in 6: 5: 5 ratios.
Claims (2)
1, a kind of preparation method of biological activity degradative membrane is characterized in that:
(1), gelatin is dissolved in the balanced salt solution PBS solution fully, is made into 0.3-5% solution;
(2), chitosan is dissolved in citric acid-phosphoric acid buffer fully, is made into 0.5-5% solution;
(3), polyvinyl alcohol is dissolved in the distilled water, is made into 3-15% solution, it is dissolved fully is water white glue;
(4), get gelatin solution, chitosan solution, polyvinyl alcohol solution, these three kinds of solution are in 4-8: 2-7: after the 3-7 ratio is mixed fully, be layered on the sheet glass seasoning film forming under the room temperature.
2, according to the preparation method of the described biological activity degradative membrane of claim 1, it is characterized in that:
(1), gelatin is dissolved in the balanced salt solution PBS solution fully, is made into 3% solution;
(2), chitosan is dissolved in citric acid-phosphoric acid buffer fully, is made into 3% solution;
(3), polyvinyl alcohol is dissolved in the distilled water, is made into 10% solution, it is dissolved fully is water white glue;
(4), get gelatin solution, chitosan solution, polyvinyl alcohol solution, these three kinds of solution are layered on the sheet glass seasoning film forming under the room temperature after mixing fully in 6: 5: 5 ratios.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100214740A CN1328316C (en) | 2004-03-26 | 2004-03-26 | Prepn process of degradable bioactive film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100214740A CN1328316C (en) | 2004-03-26 | 2004-03-26 | Prepn process of degradable bioactive film |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1673273A CN1673273A (en) | 2005-09-28 |
| CN1328316C true CN1328316C (en) | 2007-07-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100214740A Expired - Fee Related CN1328316C (en) | 2004-03-26 | 2004-03-26 | Prepn process of degradable bioactive film |
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| CN (1) | CN1328316C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101372820B (en) * | 2007-08-21 | 2010-11-17 | 马铁良 | Cigarette self-extinguishing solution and preparation thereof |
| CN102125811B (en) * | 2011-01-10 | 2012-09-05 | 杭州水处理技术研究开发中心有限公司 | Method for preparing polyvinyl alcohol-chitosan nano filtration membrane |
| CN102585264B (en) * | 2012-01-20 | 2013-06-05 | 河南科技大学 | Preparation method of gelatin/poli vinyl alcohol (PVA) composite films improved by inorganic montmorillonite |
| CN102585263B (en) * | 2012-01-20 | 2013-06-05 | 河南科技大学 | Preparation method of organic montmorillonite-modified gelatin/PVA (polyvinyl acetate) composite film |
| CN115895053B (en) * | 2022-08-04 | 2024-03-26 | 盐城工学院 | Biodegradable membrane and preparation method and application thereof |
Citations (7)
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| JPS529070A (en) * | 1975-07-11 | 1977-01-24 | Mitsubishi Monsanto Chem | Process for molding polyvinyl chloride foam |
| CN1063425A (en) * | 1992-01-17 | 1992-08-12 | 厦门大学 | The facture of high-efficient diffusion barrier |
| CN1111652A (en) * | 1994-05-10 | 1995-11-15 | 池洪 | Biodegradable pollution-free foaming water-based material |
| CN1112024A (en) * | 1995-05-01 | 1995-11-22 | 付朝宏 | Method for preparing medical biologic film |
| KR20010016482A (en) * | 2000-12-14 | 2001-03-05 | 손태원 | Soft gel comprising chitosan and gelatin |
| CN1296852A (en) * | 2000-12-12 | 2001-05-30 | 天津大学 | Chitosan/gelatin network modification on surface of aliphatic polyester |
| CN1411805A (en) * | 2001-10-11 | 2003-04-23 | 北京中科天鹤生物技术有限公司 | Biological medicine film and its preparation method |
-
2004
- 2004-03-26 CN CNB2004100214740A patent/CN1328316C/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS529070A (en) * | 1975-07-11 | 1977-01-24 | Mitsubishi Monsanto Chem | Process for molding polyvinyl chloride foam |
| CN1063425A (en) * | 1992-01-17 | 1992-08-12 | 厦门大学 | The facture of high-efficient diffusion barrier |
| CN1111652A (en) * | 1994-05-10 | 1995-11-15 | 池洪 | Biodegradable pollution-free foaming water-based material |
| CN1112024A (en) * | 1995-05-01 | 1995-11-22 | 付朝宏 | Method for preparing medical biologic film |
| CN1296852A (en) * | 2000-12-12 | 2001-05-30 | 天津大学 | Chitosan/gelatin network modification on surface of aliphatic polyester |
| KR20010016482A (en) * | 2000-12-14 | 2001-03-05 | 손태원 | Soft gel comprising chitosan and gelatin |
| CN1411805A (en) * | 2001-10-11 | 2003-04-23 | 北京中科天鹤生物技术有限公司 | Biological medicine film and its preparation method |
Non-Patent Citations (4)
| Title |
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| 壳聚糖一明胶共混膜 余家会等，武汉大学学报 自然科学版，第45卷第4期 1999 * |
| 壳聚糖水杨酸盐一明胶共混膜结构表征及其抗菌性 赵铁等，分析科学学报，第18卷第2期 2002 * |
| 壳聚糖水杨酸盐一明胶共混膜结构表征及其抗菌性 赵铁等，分析科学学报，第18卷第2期 2002;壳聚糖一明胶共混膜 余家会等，武汉大学学报 自然科学版，第45卷第4期 1999;生物可降解包装膜 陈洁等，无锡轻工大学学报，第19卷第4期 2000 * |
| 生物可降解包装膜 陈洁等，无锡轻工大学学报，第19卷第4期 2000 * |
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| CN1673273A (en) | 2005-09-28 |
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