CN111096917B - Long-acting anti-dandruff itching-relieving composition and application thereof - Google Patents
Long-acting anti-dandruff itching-relieving composition and application thereof Download PDFInfo
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- CN111096917B CN111096917B CN202010061073.7A CN202010061073A CN111096917B CN 111096917 B CN111096917 B CN 111096917B CN 202010061073 A CN202010061073 A CN 202010061073A CN 111096917 B CN111096917 B CN 111096917B
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- composition
- sodium
- extract
- dandruff
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- 239000000203 mixture Substances 0.000 title claims abstract description 62
- 208000001840 Dandruff Diseases 0.000 title abstract description 47
- 208000003251 Pruritus Diseases 0.000 title abstract description 13
- 239000000284 extract Substances 0.000 claims abstract description 52
- 241001071795 Gentiana Species 0.000 claims abstract description 29
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229960001915 hexamidine Drugs 0.000 claims abstract description 23
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000002453 shampoo Substances 0.000 claims abstract description 21
- 244000044554 Elaeagnus pungens Species 0.000 claims abstract description 20
- 235000013935 Elaeagnus pungens Nutrition 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 16
- 229910052708 sodium Inorganic materials 0.000 claims description 16
- 239000011734 sodium Substances 0.000 claims description 16
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
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- 230000002335 preservative effect Effects 0.000 claims description 7
- 239000008199 coating composition Substances 0.000 claims description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
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- 150000002148 esters Chemical class 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 4
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 4
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 4
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
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- 235000010417 guar gum Nutrition 0.000 claims description 3
- 229940083542 sodium Drugs 0.000 claims description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004711 α-olefin Substances 0.000 claims description 3
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- QGCUAFIULMNFPJ-UHFFFAOYSA-N Myristamidopropyl betaine Chemical compound CCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O QGCUAFIULMNFPJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-M alaninate Chemical compound CC(N)C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-M 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 229960003767 alanine Drugs 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 claims description 2
- LLRANSBEYQZKFY-UHFFFAOYSA-N dodecanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCCCCCC(O)=O LLRANSBEYQZKFY-UHFFFAOYSA-N 0.000 claims description 2
- 229940075468 lauramidopropyl betaine Drugs 0.000 claims description 2
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 2
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000003346 palm kernel oil Substances 0.000 claims description 2
- 235000019865 palm kernel oil Nutrition 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- 229940079781 sodium cocoyl glutamate Drugs 0.000 claims description 2
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 2
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 39
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 65
- 230000000694 effects Effects 0.000 description 34
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- 238000011156 evaluation Methods 0.000 description 17
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- 239000000523 sample Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 8
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- 241000699670 Mus sp. Species 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
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- 230000001953 sensory effect Effects 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
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- HWJHWSBFPPPIPD-UHFFFAOYSA-N ethoxyethane;propan-2-one Chemical compound CC(C)=O.CCOCC HWJHWSBFPPPIPD-UHFFFAOYSA-N 0.000 description 2
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- 150000004676 glycans Chemical class 0.000 description 2
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- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
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- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
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- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical class NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
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- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
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- 230000028327 secretion Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229940095673 shampoo product Drugs 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
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- 238000002791 soaking Methods 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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- 235000008939 whole milk Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of daily chemicals, and relates to a long-acting anti-dandruff itching-relieving composition and application thereof. The invention provides a long-acting anti-dandruff itching-relieving composition, which comprises the following components: hexamidine bis (isethionate), elaeagnus pungens extract and gentian extract. The composition provided by the invention is used in shampoo, has remarkable anti-dandruff and antipruritic effects, has good moisturizing effect, can well maintain the stable state of skin, and can be used for a long time.
Description
Technical Field
The invention belongs to the field of daily chemicals, and relates to a long-acting anti-dandruff itching-relieving composition and application thereof.
Background
Hair care is increasingly being considered by people, and some hair or scalp problems frequently occurring in hair care and hair care always plague people, such as excessive grease secretion, dandruff or dry and forked hair, etc. The anti-dandruff agents adopted in the shampoo in the market at present are salicylic acid, zinc pyrithione (ZPT for short), piroctone olamine salt and climbazole. These antidandruff agents not only have a single therapeutic route and cannot deposit on the hair for a long time, resulting in poor antidandruff antipruritic effects, but also have problems of sensitization, irritation and instability. CN201510358380.0 discloses the use of hexamidine bis (isethionic acid) salt as an antidandruff agent in products, which however does not completely eradicate the dandruff and is prone to further irritation and damage to the scalp.
Disclosure of Invention
It is an object of the present invention to provide a composition.
It is a further object of the present invention to provide a long-acting anti-dandruff and antipruritic composition.
The invention further aims to provide a preparation method of the long-acting anti-dandruff and antipruritic composition.
At present, the existing anti-dandruff agent cannot be deposited on hair for a long time, so that the anti-dandruff and antipruritic effects are poor, and therefore, the problem of poor anti-dandruff and antipruritic effects is required to be solved, and the aim of use in daily necessities is fulfilled.
In one aspect, the present invention provides a long-acting anti-dandruff antipruritic composition comprising: hexamidine bis (isethionate), extract of elaeagnus pungens, and extract of gentian.
In some embodiments, the composition comprises the following components in parts by weight: 0.001-1 part of hexamidine di (isethionic acid) salt, 0.1-10 parts of elaeagnus pungens extract and 1-5 parts of gentian extract.
In some embodiments, the composition comprises the following components in parts by weight: the hexamidine di (isethionic acid) salt content is 0.01-0.1 part, the elaeagnus pungens extract content is 1-10 parts, and the gentian extract content is 1-5 parts.
In some embodiments, the composition comprises the following components in parts by weight: 0.05-0.1 part of hexamidine di (isethionic acid) salt, 5-10 parts of elaeagnus pungens extract and 4-5 parts of gentian extract.
In the present disclosure, the elaeagnus pungens extract is mainly elaeagnus pungens polysaccharide.
In some embodiments, the composition further comprises a surfactant.
In some embodiments, the surfactant is present in an amount of 12 to 25 parts by weight.
In some embodiments, the surfactant is 15-20 parts by weight.
In one embodiment, the weight fraction of the surfactant is 16-20 parts.
In some embodiments, the surfactant is selected from one or more of sodium cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl alanine, sodium cocoyl glycinate, sodium lauroyl sarcosinate, sodium cocoyl alaninate, cocamidopropyl betaine, lauryl hydroxysulfobetaine, lauramidopropyl betaine, palm kernel oil amidopropyl betaine, myristamidopropyl betaine, sodium lauroyl amphoacetate, sodium palmitoyl amphoacetate, sodium cocoyl amphoacetate, sodium stearoyl amphoacetate, and sodium lauroyl amphodiacetate.
In one embodiment, the surfactant is selected from one or more of sodium lauroyl glutamate, alpha-olefin sulfonate and cocamidopropyl betaine.
In some embodiments, the composition further comprises a thickener.
In some embodiments, the thickener is present in an amount of 0.5 to 5 parts by weight.
In some embodiments, the thickener is 1 to 4 parts by weight.
In one embodiment, the weight portion of the thickener is 2-4.
In some embodiments, the thickener is selected from one or more of glycol laurate, propylene glycol laurate, acrylic acid (esters) based/C10-30 alkanol acrylate cross-linked polymer sodium, acrylic acid (esters) based/C10-30 alkanol acrylate cross-linked polymer potassium salt, cocamidomethyl MEA, cocamidoethyl DEA, polyquaternium-10, cationic guar, cocamidMIPA, cocamidopropylPG-dimethylammonium chloride, and cocamidopropylPG-dimethylammonium chloride phosphate.
In one embodiment, the thickener is polyquaternium-10 or cationic guar gum.
In some embodiments, the present invention also discloses a cosmetic comprising the composition, comprising the following ingredients in weight percent:
hexamidine bis (isethionic acid) salt 0.001-1%;
0.1 to 10 percent of elaeagnus pungens extract;
1-5% of gentian extract;
12-25% of a surfactant;
0.5 to 5 percent of thickening agent;
0.05 to 1 percent of preservative;
0-1% of an acid-base regulator;
0.05 to 1 percent of chelating agent
Water to 100%.
In some embodiments, the cosmetic comprises the following ingredients in weight percent:
hexamidine bis (isethionic acid) salt 0.01-0.1%;
1-10% of elaeagnus pungens extract;
3-5% of gentian extract;
15-20% of a surfactant;
1-4% of thickening agent;
0.1 to 1 percent of preservative;
0.01-1% of acid-base regulator;
chelating agent 0.1-1%
Water to 100%.
In another aspect, the present invention also provides a method of preparing a long-acting anti-dandruff antipruritic composition, said method comprising the steps of: adding fructus Elaeagni extract, radix Gentianae extract, surfactant, and thickener into hexamidine bis (isethionic acid) salt, heating to 40-80deg.C, and stirring to obtain the final product.
In some embodiments, the steps further comprise: heating water, adding the coating composition, the surfactant and the thickener, mixing and stirring, adding the preservative and the chelating agent, stirring, adding the acid-base regulator, continuously stirring, and cooling to obtain the product.
In a further aspect, the invention also provides the use of said composition in cosmetics.
In some embodiments, the cosmetic is a personal cleansing product;
in some embodiments, the cosmetic is a shampoo, but is not limited thereto.
Compared with the prior art, one embodiment has the following beneficial effects: the formula has good anti-dandruff and antipruritic effects.
The other embodiment has the beneficial effects that: has good moisturizing effect, can well maintain the stable state of skin, and can be used for a long time.
Drawings
FIG. 1 different groups of skin HE stained.
Wherein examples 1-3 are example 1, combination 3; comparative examples 1-3 are comparative example 1, combination 3; comparative examples 2-3 are comparative example 2, combination 3; comparative example 3-1 is comparative example 3 combination 1; comparative example 4-1 is comparative example 4 combination 1; comparative example 5-1 is comparative example 5 combination 1.
Detailed Description
The technical solution of the present invention is further illustrated by the following specific examples, which do not represent limitations on the scope of the present invention. Some insubstantial modifications and adaptations of the invention based on the inventive concept by others remain within the scope of the invention.
In the following examples, the extraction process of the elaeagnus pungens extract is as follows:
pulverizing fructus Elaeagni, sieving with 24 mesh sieve, adding 95% ethanol at a feed liquid ratio of 1:6, soaking for 24 hr, filtering, adding drinking water at a feed liquid ratio of 1:30 into the residue, heating to boiling and extracting for 2 hr, filtering, keeping the filtrate for later use, adding drinking water at a feed liquid ratio of 1:15 into the residue, heating to boiling and extracting for 1.5 hr, filtering, mixing the filtrates, concentrating at 65deg.C to solid content of 30% to obtain concentrated extract of fructus Elaeagni, adding 95% ethanol or anhydrous ethanol with volume 4 times of the extract, precipitating with ethanol, repeating for 2 times, filtering, and lyophilizing to obtain extract of fructus Elaeagni. Wherein the main component of the elaeagnus pungens extract is polysaccharide.
In the following examples, gentian extract was purchased from Shanghai Gayu Biotechnology Co., ltd under the trade name gentian anti-irritant factor 2.5#, and the ingredients include water, butylene glycol and gentian extract, but gentian extracts from other companies may be used in real applications.
Example 1 formulation of anti-dandruff antipruritic composition and method of preparing the same
This example aims at exploring and comparing the anti-dandruff and anti-itch effects of pre-packaged anti-dandruff and anti-itch compositions in different proportions.
Table 1 comparison of pre-packaged anti-dandruff and antipruritic compositions
The preparation method comprises the following steps:
(1) Preparation of the coating composition: heating (40-80deg.C), homogenizing and stirring at 2000-4000rpm for 5-30min to obtain coated composition.
(2) Anti-dandruff shampoo proofing process
Adding deionized water into a stirring cylinder and heating to 50 ℃; adding the coating composition prepared in the step (1) according to Table 1, and stirring for 2 hours; adding preservative and chelating agent, stirring for 1 hr, adding acid-base regulator, and stirring for 1 hr. Cooling to 30-40 ℃. Shampoo products of example 1 combinations 1-6 were obtained.
Comparative example 1 unwrapped anti-dandruff antipruritic composition and method of making same
This comparative example aims at exploring an unwrapped anti-dandruff and anti-itching composition and comparing the anti-dandruff and anti-itching effect of an anti-dandruff and anti-itching composition that was pre-wrapped.
Table 2 comparison of unwrapped anti-dandruff and antipruritic compositions
The preparation method comprises the following steps:
(1) The hexamidine bis (isethionate), the elaeagnus pungens extract and the gentian extract were weighed according to table 2 and mixed to obtain an unwrapped composition.
(2) Comparative example 1 shampoo proofing
Adding the sterilized deionized water into a stirring tank and heating to 50 ℃; adding the unwrapped composition prepared in step (1), the surfactant, and the thickener, mixing, and stirring for 2 hours according to table 2; adding the preservative and the chelating agent, stirring for 1 hour, adding the acid-base regulator, and stirring for 1 hour. Cooling to 30-40 ℃. A shampoo product of comparative example 1 in combination 1 to 6 was obtained.
Comparative example 2 anti-dandruff and antipruritic composition using different coating materials and preparation method thereof
The comparative example aims at exploring and comparing the anti-dandruff and anti-itching effects of anti-dandruff and anti-itching compositions of different coating compositions.
Table 3 anti-dandruff antipruritic compositions of different coating materials
The preparation method comprises the following steps: the preparation method was the same as that of example 1, and comparative example 2 combinations 1 to 6 were prepared.
Comparative example 3 anti-dandruff antipruritic composition after removal of hexamidine bis (isethionate) salt and process for its preparation
This comparative example aims at exploring the anti-dandruff antipruritic effect of an anti-dandruff antipruritic composition after removal of hexamidine bis (isethionate) salt and comparing with that of an anti-dandruff antipruritic composition without removal of hexamidine bis (isethionate) salt.
Table 4 comparison of anti-dandruff and antipruritic compositions after removal of hexamidine bis (isethionate)
The preparation method comprises the following steps: comparative example 3 composition 1 was prepared in the same manner as in example 1.
Comparative example 4 anti-dandruff and antipruritic composition with gentian extract removed and preparation method thereof
This comparative example was intended to explore the anti-dandruff and antipruritic effects of anti-dandruff and antipruritic compositions without gentian extract being removed.
Table 5 comparison of anti-dandruff and antipruritic compositions after removal of gentian extract
The preparation method comprises the following steps: comparative example 4 composition 1 was prepared in the same manner as in example 1. Comparative example 5 anti-dandruff antipruritic compositions with different actives
Table 6 comparison of anti-dandruff and antipruritic compositions with different actives
The preparation method comprises the following steps: the preparation method of combinations 1 to 3 in comparative example 5 was the same as that of example 1.
Example 2 evaluation of Performance
1. Evaluation of antibacterial effect of composition on malassezia
1.1 Experimental materials and methods
(1) Material
Strains: malachite color fungus standard strain (ATCC 44344)
Culture medium: LAN medium: 1% peptone, 0.05% glucose, 0.1% yeast extract, 0.4% dried oxgall, 0.1% glycerol, 0.05% glycerol monostearate, 2% olive oil, 0.05% tween-60, 1% whole milk, 1.2% agar, 0.05% chloramphenicol. LAM liquid medium: LAM medium was supplemented with 2% olive oil.
Sample: the prepared sample was dissolved in distilled water at a concentration of 0.1g/mL, 100. Mu.L of the stock solution was taken and added to 900. Mu.L of LAN liquid medium at an initial concentration of 10mg/mL.
(2) Method of
Fungus inoculation: the test bacteria are continuously subcultured in LAN culture medium for 2 times, after subculturing at 32deg.C for 4 days, the colony is eluted and purified with sterile physiological saline, and the bacteria content is determined and diluted to (1-2) x 10 5 CFU/mL。
Preparing a micro drug sensitive plate: 100 mu L of culture medium, 200 mu L of sample solution in 1 hole and multiple dilution in 2-10 holes are added into 2-11 holes of a 96-well plate, and 11 holes are used as growth control.
Inoculating: inoculating 1-11 holes with 5 μl of olive oil, and shaking and mixing.
Interpretation of the results: the inoculated drug sensitive plate is placed in a wet box for culturing for 72 hours at 32 ℃ and the growth condition is observed. MIC values are the lowest drug concentration without fungal growth.
1.2 experimental results
(1) Results of the compositions of example 1 and comparative examples 1 and 2 (unwrapped and replacement wrap)
TABLE 7 minimum drug concentration (MIC) of malassezia
The experimental data in table 7 show that combinations 1-6 of example 1 achieve a bacteriostatic MIC at lower concentrations that is significantly better than combinations 1-6 in comparative example 1 and 1-6 in comparative example 2. Experimental results show that the effect of adding the elaeagnus pungens extract into the composition is superior to that of pullulan, and meanwhile, the composition containing the elaeagnus pungens extract is also demonstrated to have different preparation process effects, and the effect after wrapping is superior to that before wrapping.
(2) Results of some examples and comparative example 3 (rejection of hexamidine bis (isethionate)) salts
Table 8 minimum drug concentration (MIC) of malassezia
The results in table 8 show that, compared to example 1, combination 3 and example 1, combination 4, the inhibition of malassezia is significantly reduced and the minimum inhibitory concentration is greatly increased due to the removal of hexamidine bis (isethionic acid) salt from comparative example 3, combination 1.
(3) Results of some examples and comparative examples 4 and 5 (rejection or replacement of gentian extract)
TABLE 9 minimum drug concentration (MIC) of malassezia
The results in table 9 show that the inhibition of malassezia was slightly significantly reduced due to the removal of the gentian extract from comparative example 4, combination 1, compared to example 1, combination 5 and example 1, combination 3. While comparative example 5, combinations 1 to 3, resulted in a decrease in the bacteriostatic effect of comparative example 5, combinations 1 to 3, due to the replacement of gentian extract with other substances.
2. Evaluation of antipruritic efficacy of compositions
2.1 Experimental materials and methods
(1) Experimental grouping: blank control group, model group, experimental sample group, six mice per group.
(2) Dehairing: firstly, shearing coarse hairs on the backs of the mice by scissors, then removing the residual hairs by an electric shaver, and lightly smearing 10% sodium sulfide on the backs of the mice to enable the hairs to be removed fully and the backs to be exposed fully.
(3) Experimental treatment: mice of the model group and the experimental sample group were soaked with 1:1 acetone-diethyl ether mixture cotton balls for 40s, then distilled water for 40s, and the blank group was soaked with water for 80s 2 times a day (9 am and 5 pm) for 7 days.
(4) Sample treatment: the model group and the blank group are not subjected to sample coating treatment, corresponding samples are respectively coated on the experimental sample groups, the samples are coated twice a day in one week of acetone-diethyl ether treatment, and the samples are washed by adopting deionized water, wherein the sample amount is 200 mu L/sample.
(5) Sampling evaluation
Skin conditions were recorded daily, the percutaneous loss TWEL and the number of writhing in 2 hours were determined, and the back skin was taken after the mice were sacrificed by cervical removal, 4% paraformaldehyde fixation, and subsequent HE staining.
2.2 results
(1) Results of the compositions of example 1 and comparative examples 1 and 2 (unwrapped and replacement of elaeagnus pungens extract wrap)
Table 10 variation of percutaneous Water loss Rate and number of writhing in different groups
The results in Table 10 show that the percutaneous loss rates of comparative example 1 combinations 1-6 are significantly higher than those of example 1 combinations 1-6, with some increase in the number of writhing. Comparative example 2 combinations 1-6 the percutaneous water loss rate was significantly higher than example 1 combinations 1-6 due to the replacement of the elaeagnus pungens extract, and the number of twists was increased to some extent. Experimental results show that the combination 1-6 in the embodiment 1 has remarkable skin moisturizing effect.
(2) Results of some examples and comparative example 3 (rejection of hexamidine)
TABLE 11 variation of percutaneous Water loss and number of writhing in different groups
As shown in table 11, compared with example 1, combination 3 and example 4, comparative example 3, combination 1, after removal of hexamidine bis (hydroxyethylsulfonate), had less change in skin water retention efficacy, slightly deteriorated, and the efficacy of example 1, combination 3 and example 1, combination 4 for water retention and itching relieving was superior to that of comparative example 3, combination 1.
(3) Results of some examples and comparative examples 4 and 5 (rejection and replacement of gentian extract)
TABLE 12 variation of percutaneous Water loss and number of writhing in different groups
As shown in the results of table 12, as compared with example 1, combination 3 and example 1, combination 5, since comparative example 4, combination 1, removed gentian extract, its moisturizing effect as well as antipruritic effect was significantly deteriorated, as shown in the results of table 12, as compared with example 1, combination 3 and example 1, combination 5, the moisturizing and antipruritic effects were significantly reduced since gentian extract in comparative example 5, combinations 1-3, was replaced with other components.
(4) HE staining results
As shown in fig. 1, the skin cells were significantly thickened in the model group compared to the blank group as a result of HE staining of the back skin of the mice of the different groups. Example 1, comparative example 3, comparative example 2, comparative example 3, comparative example 4, comparative example 1, comparative example 5, and comparative example 1 are capable of remarkably suppressing the thickening of the epidermis, and have a good effect of maintaining the skin state, a certain effect of maintaining the skin barrier, and a remarkable effect of maintaining the cell homeostasis.
3. Efficacy evaluation of the composition for shampoo products
3.1 sensory efficacy evaluation procedure
Test materials: shampoo prepared from different formulas.
Test object: 10 persons in each group had an age distribution of 18-45 years and were each shampoo randomly grouped for sensory evaluation testing. Each sample was tested for 1 month, and the tester followed experience sensory scores with a score scale of 10 points, 1 point being the worst, 10 points being the best, with higher scores being the better.
3.2 test results are as follows
(1) Results of the compositions of examples and comparative examples 1 and 2 (unwrapped and replacement of elaeagnus pungens extract wrap)
Table 13 evaluation of different shampoo use effects
Table 14 evaluation of different shampoo use effects
Table 15 evaluation of different shampoo use effects
The results in tables 13, 14 and 15 show that the cleaning effect and refreshing feel of the shampoo are not significantly different in the comparative example 1 combinations 1 to 6 compared with the example 1 combinations 1 to 6; the antidandruff effect, antipruritic effect and oil control effect are inferior to those of the combination 1-6 of example 1. Comparative example 2 in combination 1 to 6, the difference in the cleaning effect and refreshing feel of the shampoo was not obvious; but the antidandruff effect, antipruritic effect and oil control effect are inferior to the combination of examples 1-6. The results show that the combination 1-6 of example 1 has better anti-dandruff effect and obvious antipruritic effect, and the overall evaluation effect is better than that of the compositions in comparative examples 1 and 2.
(2) Results of some examples and comparative example 3 (rejection of hexamidine)
Table 16 evaluation of different shampoo use effects
As shown in table 16, the difference between the cleaning effect and the refreshing feel oil control effect of the shampoo after removing hexamidine bis (isethionic acid) salt was not obvious in comparative example 3, combination 1, compared with example 1, combination 3 and example 1, combination 4; but the anti-dandruff effect and antipruritic effect are remarkably deteriorated. The antipruritic effect of example 1, combination 3 and example 1, combination 4 was remarkable, and the overall evaluation effect was superior to that of comparative example 3.
(3) Results of some examples and comparative examples 4 and 5 (rejection and replacement of gentian extract)
Table 17 evaluation of different shampoo use effects
As shown in table 17, the difference in the cleaning effect and refreshing feeling of the shampoo after the gentian extract was removed was not obvious in comparative example 4, combination 1, compared to example 1, combination 3 and example 1, combination 5; but the anti-dandruff effect and the oil control effect are deteriorated. Wherein example 1, combination 3 and example 1, combination 5 are very significantly better than comparative example 4, combination 1, for antipruritic effect.
Comparative example 5 the shampoo has insignificant difference in cleaning effect and refreshing feel after the gentian extract is replaced by combination 1-3; however, for the antidandruff effect, antipruritic effect and oil control effect, example 1 combination 3 and example 1 combination 5 are significantly better than comparative example 5 combinations 1-3.
Thus, it can be seen that the antipruritic effect of example 1, combination 3 and example 1, combination 5 is more pronounced, and the overall evaluation effect is superior to the rejection or replacement of the compositions of comparative examples 4 and 5 in the gentian extract, in which the gentian extract exerts a significant antipruritic effect.
Through human efficacy experiment detection, the anti-dandruff shampoo of the embodiment 1 has better anti-dandruff and antipruritic effects than the comparative example, and has no difference in the evaluation of cleaning effect, refreshing feel and the like, and the overall evaluation is better than the comparative example.
Claims (9)
1. A composition, characterized by comprising the following components in percentage by weight:
hexamidine bis (isethionic acid) salt 0.001-1%;
0.1 to 10 percent of elaeagnus pungens extract;
1-5% of gentian extract;
12-25% of a surfactant;
0.5 to 5 percent of thickening agent;
0.05 to 1 percent of preservative;
0-1% of an acid-base regulator;
0.05-1% of chelating agent;
water to 100%;
the preparation method of the composition comprises the following steps:
adding the elaeagnus pungens extract, the gentian extract, the surfactant and the thickener into hexamidine bis (isethionic acid) salt, heating to 40-80 ℃, and stirring to obtain a coating composition;
adding the coating composition into hot water at 45-80 ℃ and stirring; adding chelating agent and antiseptic, stirring, adding acid-base regulator, stirring, and cooling.
2. The composition of claim 1, comprising the following ingredients in weight percent:
hexamidine bis (isethionic acid) salt 0.01-0.1%;
1-10% of elaeagnus pungens extract;
3-5% of gentian extract;
15-25% of a surfactant;
1-4% of thickening agent;
0.1 to 1 percent of preservative;
0.01-1% of acid-base regulator;
0.1 to 1 percent of chelating agent;
water to 100%.
3. The composition of claim 1, wherein the surfactant is selected from one or more of sodium cocoyl glutamate, alpha olefin sulfonate, sodium lauroyl glutamate, sodium myristoyl alanine, sodium cocoyl glycinate, sodium lauroyl sarcosinate, sodium cocoyl alaninate, cocamidopropyl betaine, lauryl hydroxysulfobetaine, lauramidopropyl betaine, palm kernel oil amidopropyl betaine, myristamidopropyl betaine, sodium lauroyl amphoacetate, sodium palmitoyl amphoacetate, sodium cocoyl amphoacetate, sodium stearoyl amphoacetate, and sodium lauroyl amphodiacetate.
4. The composition of claim 1, wherein the surfactant is selected from one or more of sodium lauroyl glutamate, alpha olefin sulfonate, and cocamidopropyl betaine.
5. The composition of claim 1, wherein the thickener is selected from one or more of propylene glycol laurate, acrylic acid (esters) based/C10-30 alkyl acrylate cross-linked polymer, acrylic acid (esters) based/C10-30 alcohol acrylate cross-linked polymer sodium, acrylic acid (esters) based/C10-30 alcohol acrylate cross-linked polymer potassium salt, cocoamidomethyl MEA, cocoamidomea, cocoamidodea, polyquaternium-10, cationic guar gum, cocoamidomipa, cocoamidopropyl PG-dimethyl ammonium chloride, and cocoamidopropyl PG-dimethyl ammonium chloride phosphate.
6. The composition of claim 1, wherein the thickener is one or both of polyquaternium-10 and cationic guar gum.
7. Use of a composition according to any one of claims 1 to 6 for the preparation of a cosmetic product.
8. The use according to claim 7, wherein the cosmetic product is a personal cleansing product.
9. The use according to claim 7, wherein the cosmetic product is a shampoo.
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