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CN107496317B - Repairing and nursing shampoo containing periplaneta americana active ingredient - Google Patents

Repairing and nursing shampoo containing periplaneta americana active ingredient Download PDF

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CN107496317B
CN107496317B CN201710603252.7A CN201710603252A CN107496317B CN 107496317 B CN107496317 B CN 107496317B CN 201710603252 A CN201710603252 A CN 201710603252A CN 107496317 B CN107496317 B CN 107496317B
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periplaneta americana
surfactant
filter residue
agent
extract
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CN107496317A (en
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李映波
孙旭敏
孙笠雯
赵思聪
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Yunnan Ningkang Biological Technology Co., Ltd.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/008Preparations for oily hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/596Mixtures of surface active compounds

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Abstract

The invention relates to a repairing and nursing shampoo containing periplaneta americana active ingredients, and belongs to the technical field of daily chemical products. The repairing and nursing shampoo comprises periplaneta americana extract, horse chestnut fruit extract, an anionic surfactant, a zwitterionic surfactant, a nonionic surfactant, an amino acid surfactant, a special surfactant, a high molecular polymer, a chelating agent, a humectant, a sun-screening agent, a pearling agent, a neutralizing agent, a thickening agent, a nutritional agent, a preservative, essence and water. The shampoo disclosed by the invention has an antioxidant effect, can improve the cell activity, promote the surface cell growth, the hair follicle regeneration and the hair scale repair, and also can promote the hair growth and the grease secretion of the hair lipid gland, and is easy to popularize and apply.

Description

Repairing and nursing shampoo containing periplaneta americana active ingredient
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to a repairing and nursing shampoo containing periplaneta americana active ingredients.
Background
The shampoo is mainly composed of main active agent, auxiliary active agent and additive, and can remove oil stain and dandruff on the surface of hair and scalp without adverse effect on hair, scalp and human health. The shampoo has various types, and is mainly classified into restoration and nursing shampoo, transparent shampoo, paste shampoo, pearlescent shampoo, conditioning shampoo, anti-dandruff shampoo, special shampoo and the like according to the dosage form and the function.
In recent years, due to the improvement of life quality of people and the increase of hair washing times, more and more requirements and efficacies are put forward on the shampoo. The shampoo is required to have good decontamination and anti-dandruff effects, good moisturizing, repairing and nursing performances and good combing performance after hair washing; on the other hand, it is required that the shampoo has the effects of conditioning, caring, repairing, and maintaining the beauty of hair, and also has the effects of nourishing and refreshing the skin.
At present, no repairing and nursing shampoo prepared by adopting the periplaneta americana is found.
Disclosure of Invention
The invention aims to solve the defects of the prior art and provides a repairing and nursing shampoo containing periplaneta americana active ingredients, which has an antioxidation effect, can improve the cell activity, promote the growth of surface cells, the regeneration of hair follicles and the repair of hair scales, and can also promote the growth of hairs and the secretion of grease from hair and sebaceous glands.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a repairing and nursing shampoo containing periplaneta americana active ingredients comprises the following components in percentage by mass:
Figure BDA0001357696850000011
Figure BDA0001357696850000021
wherein the anionic surfactant is one or more of ammonium laureth sulfate, ammonium lauryl sulfate, α -sodium alkenyl sulfonate (AOS), sodium dodecyl sulfate, fatty alcohol polyoxyethylene ether phosphate (AEOP) and fatty alcohol polyoxyethylene ether ammonium sulfate (AESA);
the zwitterionic surfactant is one or more of carboxylate type imidazoline, sulfonate type imidazoline, cocamidopropyl betaine and dodecyl dimethyl betaine;
the nonionic surfactant is one or more of PEG-7M, fatty alcohol polyoxyethylene ether, coconut diethanolamide (6501), lauryl glucoside, alkyl glucoside and water-soluble lanolin;
the amino acid surfactant is one or more of sodium lauroyl sarcosinate, sodium lauroyl glutamate, sodium cocoyl glycinate and potassium cocoyl glycinate;
specific surfactants are dodecyl dimethyl amine oxide (OA-12);
the soft conditioning agent is one or a combination of more of D-panthenol, polyquaternium-10 and polyquaternium-39;
the functional additive is one or more of β -dextran, ethylhexyl glycerol, allantoin, anhydrous betaine and Hyaluronic Acid (HA).
Further, preferably, the repairing and caring shampoo containing the periplaneta americana active ingredient comprises the following components in percentage by mass:
Figure BDA0001357696850000022
Figure BDA0001357696850000031
further, preferably, the periplaneta americana extract is an extract obtained by ethanol extraction of the periplaneta americana.
Further, preferably, the preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to 60-200um, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding 95% ethanol, rotating and leaching for 3-4 hours at 44-46 ℃, then filtering, and drying filter residues in an oven at 49-51 ℃;
the mass ratio of the periplaneta americana body powder to 95 vol% ethanol is 0.5-3: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH value of 2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH value of 2.0 is 1g:20-40mL, extracting at the temperature of 59-61 ℃ for 58-62min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH value of 7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH value of 7.5 is 1g:20-40mL, extracting at the temperature of 59-61 ℃ for 58-62min, and filtering to obtain filtrate B and filter residue B;
adding the filter residue B into the buffer solution with the pH value of 8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH value of 7.5 is 1g:20-40mL, extracting at the temperature of 59-61 ℃ for 58-62min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at the temperature of 80 +/-1 ℃ to obtain the periplaneta americana extract.
The concentration of each component in each buffer solution in the present invention is not particularly limited, and is limited only to the pH value.
The invention adopts the rotary evaporator to rotate and does not concentrate in the leaching process, and does not start the vacuum pump.
Further, preferably, the preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruit to minus 120 mesh, extracting with water as extraction solvent under rotary reflux for three times in a rotary evaporator, each time for 3.5-4.5 hr, wherein the mass of water used in the first and second extraction is 5.8-6.2 times of that of horse chestnut fruit; the water used for the third extraction accounts for 3.8-4.2 times of the fruit mass of horse chestnut, and the extractive solutions are combined and concentrated to obtain the final product.
Further, preferably, the high molecular polymer is one or a combination of more of cationic guar gum, polyquaternium-10, xanthan gum, polyquaternium-39 and polyquaternium-7;
the chelating agent is one or two of Ethylene Diamine Tetraacetic Acid (EDTA) and disodium ethylene diamine tetraacetic acid (EDTA-2 Na).
Further, preferably, the humectant is one or a combination of more of PEG-7M, glycerol (glycerin), NMF-50, hyaluronic acid and ethylhexylglycerin;
the sun-screening agent is one or the combination of two of zinc oxide and titanium dioxide.
Further, it is preferable that the pearlescent agent is ethylene glycol distearate;
the neutralizer is one or more of triethanolamine, citric acid, sodium citrate and sodium hydroxide.
Further, preferably, the thickener is one or a combination of coconut oil diethanolamide (6501), sodium chloride and 658 thickener.
Further, it is preferable that the nutrient is one or a combination of both of collagen and periplaneta americana extract.
Further, the preservative is preferably one or a combination of more of sodium benzoate, cason, benzoic acid, katon, parachlorometaxylenol, triclocarban and potassium sorbate;
the essence is one or more of herba Menthae Rotundifoliae essence, semen Sesami essence, fructus Amomi rotundus essence, flos Chrysanthemi essence, flos Jasmini sambac essence, and herba Menthae essence;
it will be understood by those skilled in the art that when the nutrient is selected to be periplaneta americana extract, the total amount of periplaneta americana extract contained in the shampoo for repair and care will be the sum of the amount of periplaneta americana extract in the original formulation and the amount of periplaneta americana extract in the nutrient. For another example, the soft conditioner adopts polyquaternium-10, the dosage of the partial polyquaternium-10 is the dosage of the soft conditioner, and meanwhile, if the high molecular polymer also adopts polyquaternium-10, and the dosage of the partial polyquaternium-10 is the dosage of the high molecular polymer, the total dosage of the polyquaternium-10 is the total amount of the soft conditioner and the high molecular polymer.
The water is deionized water.
The horse chestnut fruit extract contains escin, promotes microcirculation, maintains normal metabolism of cells, thereby promoting pore convergence, cleanness and nourishment and leading skin to be delicate and purer; has the functions of resisting inflammation, resisting exudation, protecting cranial nerve, etc., and is well combined with the American cockroach extract to enhance the functions.
The essence is not particularly limited in the invention, and can also be a spice.
The preparation method of the product is not particularly limited, and the conventional shampoo preparation method can be adopted, and the conventional physical and mechanical mixing can be adopted, but the preparation method is not limited.
The periplaneta americana extract added in the invention contains a large amount of protein, has detected that the protein contains up to 18 amino acids, and has the effects of repairing hair follicles, regenerating hair follicles, moistening scalp, preventing alopecia and the like.
Compared with the American cockroach extract extracted by the conventional method, the American cockroach extract extracted by the method disclosed by the invention retains the effective components to the maximum extent, removes the taste emitted by cockroach glands remained in the extract by the conventional method, and obviously improves the subjective feeling of application.
Compared with the prior art, the invention has the beneficial effects that:
the shampoo has an antioxidation effect, can improve the cell activity, promote the growth of surface cells, the regeneration of hair follicles and the repair of hair scales, and can also promote the growth of hair and the secretion of grease from hair lipid glands.
The shampoo adopts a formula containing the periplaneta americana extract, and amino acids (such as glycine, methionine, cystine and the like) in the periplaneta americana extract can effectively promote hair growth and simultaneously improve migraine and nerve defect degree; escin in the horse chestnut fruit extract can promote microcirculation and maintain normal metabolism of cells, thereby promoting convergence of pores, cleaning and nourishing, and ensuring skin to be delicate and flawless.
Detailed Description
The present invention will be described in further detail with reference to examples.
It will be appreciated by those skilled in the art that the following examples are illustrative of the invention only and should not be taken as limiting the scope of the invention. The examples do not specify particular techniques or conditions, and are performed according to the techniques or conditions described in the literature in the art or according to the product specifications. The materials or equipment used are not indicated by manufacturers, and all are conventional products available by purchase.
Example 1
Figure BDA0001357696850000061
The periplaneta americana extract is an extract obtained by ethanol extraction of the periplaneta americana.
Example 2
Figure BDA0001357696850000062
Figure BDA0001357696850000071
The preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to 60-200um, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding ethanol with the volume concentration of 95%, rotating and leaching for 3 hours at 44 ℃, then filtering, and drying filter residues in an oven at 49 ℃;
the mass ratio of the periplaneta americana body powder to 95 vol% ethanol is 0.5: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH value of 2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH value of 2.0 is 1g:20mL, extracting at the temperature of 59 ℃ for 58min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH value of 7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH value of 7.5 is 1g:20mL, extracting at 59 ℃ for 58min, and filtering to obtain filtrate B and filter residue B;
adding the filter residue B into the buffer solution with the pH value of 8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH value of 7.5 is 1g:20mL, extracting at 59 ℃ for 58min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at 79 ℃ to obtain the periplaneta Americana extract.
The preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruits to minus 120 mesh, extracting with water as extraction solvent under rotary reflux for three times (3.5 hr each time) in a rotary evaporator, wherein the mass of water used in the first and second extraction is 5.8 times of that of horse chestnut fruits; and (3) the mass of water used for the third extraction is 3.8 times of that of the horse chestnut fruits, and the extracting solutions are combined and concentrated to obtain the horse chestnut fruit extract.
Example 3
Figure BDA0001357696850000081
Figure BDA0001357696850000091
Figure BDA0001357696850000101
The preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to 60-200um in particle size, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding ethanol with the volume concentration of 95%, rotating and leaching for 4 hours at 46 ℃, then filtering, and drying filter residues in a 51 ℃ oven;
the mass ratio of the periplaneta americana body powder to 95 vol% ethanol is 3: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH value of 2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH value of 2.0 is 1g:40mL, extracting at the temperature of 61 ℃ for 62min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH value of 7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH value of 7.5 is 1g:40mL, extracting at 61 ℃ for 62min, and filtering to obtain a filtrate B and a filter residue B;
adding the filter residue B into the buffer solution with the pH value of 8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH value of 7.5 is 1g:40mL, extracting at 61 ℃ for 62min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at the temperature of 81 ℃ to obtain the periplaneta americana extract.
The preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruits to minus 120 mesh, extracting with water as extraction solvent under rotary reflux for three times (4.5 hr each time) in a rotary evaporator, wherein the mass of water used in the first and second extraction is 6.2 times of that of horse chestnut fruits; the water used for the third extraction is 4.2 times of the fruit of horse chestnut in mass, and the extracting solutions are combined and concentrated to obtain the horse chestnut fruit extract.
Example 4
Figure BDA0001357696850000102
Figure BDA0001357696850000111
The preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to 60-200um, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding ethanol with the volume concentration of 95%, rotating and leaching for 3.5 hours at 45 ℃, then filtering, and drying filter residues in a 50 ℃ oven;
the mass ratio of the periplaneta americana body powder to 95% ethanol by volume concentration is 2.4: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH value of 2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH value of 2.0 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH value of 7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH value of 7.5 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain a filtrate B and a filter residue B;
adding the filter residue B into the buffer solution with the pH value of 8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH value of 7.5 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at 80 ℃ to obtain the periplaneta Americana extract.
The preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruits to minus 120 mesh, performing rotary reflux extraction in a rotary evaporator for three times (4 hr each time) with water as extraction solvent, wherein the mass of water used in the first and second extraction is 6 times that of horse chestnut fruits; and (3) the mass of water used for the third extraction is 4 times of that of the horse chestnut fruits, and the extracting solutions are combined and concentrated to obtain the Chinese medicinal herb tea.
Example 5
Figure BDA0001357696850000121
Figure BDA0001357696850000131
The preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to 60-200um, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding ethanol with the volume concentration of 95%, rotating and leaching for 3.5 hours at 45 ℃, then filtering, and drying filter residues in a 50 ℃ oven;
the mass ratio of the periplaneta americana body powder to 95% ethanol by volume concentration is 2.4: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH value of 2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH value of 2.0 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH value of 7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH value of 7.5 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain a filtrate B and a filter residue B;
adding the filter residue B into the buffer solution with the pH value of 8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH value of 7.5 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at 80 ℃ to obtain the periplaneta Americana extract.
The preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruits to minus 120 mesh, extracting with water as extraction solvent under rotary reflux for three times (3.8 hr each time) in a rotary evaporator, wherein the mass of water used in the first and second extraction is 6.1 times of that of horse chestnut fruits; the water used for the third extraction is 3.9 times of the fruit of horse chestnut in mass, and the extracting solutions are combined and concentrated to obtain the horse chestnut fruit extract.
Example 6
Figure BDA0001357696850000141
The preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to 60-200um, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding ethanol with the volume concentration of 95%, rotating and leaching for 3.5 hours at 45 ℃, then filtering, and drying filter residues in a 50 ℃ oven;
the mass ratio of the periplaneta americana body powder to 95% ethanol by volume concentration is 2.4: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH value of 2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH value of 2.0 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH value of 7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH value of 7.5 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain a filtrate B and a filter residue B;
adding the filter residue B into the buffer solution with the pH value of 8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH value of 7.5 is 1g:30mL, extracting at the temperature of 60 ℃ for 60min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at 80 ℃ to obtain the periplaneta Americana extract.
The preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruits to minus 120 mesh, performing rotary reflux extraction in a rotary evaporator for three times (1 hr each time) with water as extraction solvent, wherein the mass of water used in the first and second extraction is 6 times that of horse chestnut fruits; and (3) the mass of water used for the third extraction is 1 time of that of the horse chestnut fruits, and the extracting solutions are combined and concentrated to obtain the Chinese medicinal herb tea.
The preparation method of the 6 embodiments adopts the conventional preparation method in the technical field, and has no special requirement.
Test example 1
The evaluation was carried out by 32 persons after washing the hair with the invented shampoo for the volunteers in a manner of sensory evaluation, and the evaluation was carried out in the aspects of spreadability, gloss, appearance, fragrance, adaptability, hand feeling, etc., with 6 points, 6 points being the highest points and 1 point being the lowest points. The scoring criteria are shown in table 1 below, and the results are shown in table 2 below. Meanwhile, the contents of microorganisms and heavy metals in the present invention were measured, and the results are shown in table 3.
TABLE 1
Figure BDA0001357696850000151
Figure BDA0001357696850000161
TABLE 2
Figure BDA0001357696850000162
Figure BDA0001357696850000171
Summary of the test: the sensory and physical and chemical indexes of the product reach the national standard.
TABLE 3
Numbering Item Detection standard Products of the invention
1 Total number of colonies ≤1000 <10
2 Total number of mold and yeast ≤100 <10
3 Fecal coliform group Cannot be detected Not detected out
4 Staphylococcus aureus Cannot be detected Not detected out
5 Pseudomonas aeruginosa Cannot be detected Not detected out
6 Lead (in pb) (mg, kg-1) ≤40 <1.1
7 Mercury (in Hg) (mg, kg-1) ≤1 <0.2
8 Arsenic (in As) (mg, kg-1) ≤10 <3.5
Summary of the test: the product reaches and is superior to the national standard in microbe and heavy metal.
Test example 2 test of repairing and nursing effects
Test object
After dyeing and scalding, the hair is seriously damaged, the hair is easy to split, the hair is dry and frizzy, the hair is broken and falls off, and the scalp is itchy.
Second, inclusion criteria
1. Age 15-63 years;
2. voluntarily participate in the 8-week trial;
3. the whole body has good condition and no allergic history;
third, the test methods are shown in Table 4
Control group 1: shampoo purchased from market
Control group 2: control 2 shampoo differed from example 5 in that no periplaneta americana extract was added;
control group 3: control 3 shampoo was different from example 5 in that no horse chestnut fruit extract was added;
test groups: the restoration care shampoo containing the periplaneta americana active ingredient prepared in examples 1-6.
The wash was performed once daily for week 1, and once every 1 day for week 2, 3 times per week. Two groups of patients are treated for 8 weeks as a treatment course.
Observation index
The curative effect evaluation standard shows the effect: the objective signs of the head of a patient (hair is seriously damaged after dyeing and scalding, hair is easy to split, and hair is dry and frizzy), subjective symptoms (broken hair and hair loss) and the like are greatly improved by 60-87%. The results are shown in Table 4
TABLE 4
Figure BDA0001357696850000181
The product of the invention has the following using method and quality evaluation results:
trial results
1. Placing about 5g of the shampoo in the palm of the hand, then rubbing and kneading the shampoo with the two hands uniformly, coating the uniformly-opened shampoo on the whole head, massaging the head for a few minutes, and then cleaning the shampoo; observation phenomena are as follows: the product is easy to disperse uniformly, smooth and has no agglomeration.
2. After being rinsed for 2 times, the fabric is basically free of bubbles and is not sticky in hand feeling.
3. When the hair is washed and dried, the hair is combed by taking the comb without knotting and difficult combing feeling.
4. After the hair is dry, the hair is glossy and the scalp is very fresh, the hair is soft and smooth when touched by hands, and the hair scales which feel harsh to the hands after being used for a long time are generated.
It can be seen from table 4 that the shampoo of the present invention has stronger anti-dandruff ability than the ordinary shampoo, and can repair and care damaged hair, strengthen hair roots, prevent hair loss, and promote hair to grow rapidly, the mutual matching of the periplaneta americana extract and the horse chestnut fruit extract in the formulas of examples 1-6, compared with the single use of the periplaneta americana extract (control group 3) and the single use of the horse chestnut extract (control group 2), the time for achieving the effects of repairing and caring damaged hair, strengthening hair roots, preventing hair loss, and promoting hair to grow rapidly is shorter, and the synergistic effect among natural products is shown.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (8)

1. The repairing and nursing shampoo containing the periplaneta americana active component is characterized by comprising the following components in percentage by mass:
0.1-1.5% of periplaneta americana extract;
1-5% of horse chestnut fruit extract;
5-12% of an anionic surfactant;
3-10% of a zwitterionic surfactant;
3-8% of a nonionic surfactant;
0.5-5% of amino acid surfactant;
1-6% of a special surfactant;
0.08-0.5% of high molecular polymer;
0.08-1.8% of chelating agent;
0.5-3% of a humectant;
0.1-1.0% of a sun-screening agent;
1-3.2% of pearling agent;
0.2-1.0% of a softening conditioner;
0.1-0.5% of a neutralizer;
0.1-1.5% of a thickening agent;
0.5-3.0% of a nutrient;
0.1-1.0% of functional additive;
0-0.2% of a preservative;
0-0.35% of essence;
the balance of water;
the total amount is 100%;
wherein the anionic surfactant is one or more of ammonium laureth sulfate, ammonium lauryl sulfate, α -sodium alkenyl sulfonate, sodium dodecyl sulfate, fatty alcohol-polyoxyethylene ether phosphate and fatty alcohol-polyoxyethylene ether ammonium sulfate;
the zwitterionic surfactant is one or more of carboxylate type imidazoline, sulfonate type imidazoline, cocamidopropyl betaine and dodecyl dimethyl betaine;
the nonionic surfactant is one or more of PEG-7M, fatty alcohol polyoxyethylene ether, coconut oil diethanolamide, alkyl glycoside and water-soluble lanolin;
the amino acid surfactant is one or more of sodium lauroyl sarcosinate, sodium lauroyl glutamate, sodium cocoyl glycinate and potassium cocoyl glycinate;
the special surfactant is dodecyl dimethyl amine oxide;
the soft conditioning agent is one or a combination of more of D-panthenol, polyquaternium-10 and polyquaternium-39;
the functional additive is one or more of β -dextran, ethylhexyl glycerol, allantoin, anhydrous betaine and hyaluronic acid;
the preparation method of the periplaneta americana extract comprises the following steps:
step (1), crushing dried periplaneta americana bodies to a particle size of 60-200 μm, pouring the crushed periplaneta americana body powder into a rotary evaporator test bottle, then adding ethanol with the volume concentration of 95%, rotating and leaching for 3-4 hours at 44-46 ℃, then filtering, and drying filter residues in an oven at 49-51 ℃;
the mass ratio of the periplaneta americana body powder to 95 vol% ethanol is 0.5-3: 12;
step (2), 3 kinds of buffer solutions with the pH values of 2.0, 7.5 and 8.3 are prepared by citric acid and disodium hydrogen phosphate respectively for later use;
step (3), adding the filter residue dried in the step (1) into the buffer solution with the pH =2.0 prepared in the step (2), wherein the mass-to-volume ratio of the dried filter residue to the buffer solution with the pH =2.0 is 1g:20-40mL, extracting at the temperature of 59-61 ℃ for 58-62min, and filtering to obtain filtrate A and filter residue A;
adding the filter residue A into the buffer solution with the pH =7.5 prepared in the step (2), wherein the mass-volume ratio of the filter residue A to the buffer solution with the pH =7.5 is 1g:20-40mL, extracting at 59-61 ℃ for 58-62min, and filtering to obtain filtrate B and filter residue B;
adding the filter residue B into the buffer solution with the pH =8.3 prepared in the step (2), wherein the mass-volume ratio of the filter residue B to the buffer solution with the pH =7.5 is 1g:20-40mL, extracting at 59-61 ℃ for 58-62min, and filtering to obtain filtrate C and filter residue C;
and combining the filtrate A, the filtrate B and the filtrate C, concentrating into an extract, and drying at the temperature of 80 +/-1 ℃ to obtain the periplaneta americana extract.
2. The repair and care shampoo containing the periplaneta americana active ingredient according to claim 1 is characterized by comprising the following components in percentage by mass:
0.1-1.3% of periplaneta americana extract;
1.5-4% of horse chestnut fruit extract;
5-8% of an anionic surfactant;
4-6% of a zwitterionic surfactant;
4-6% of a nonionic surfactant;
1.0-4.0% of amino acid surfactant;
1.5-5% of a special surfactant;
0.1-0.4% of high molecular polymer;
0.1-1.5% of a chelating agent;
0.8-2.5% of a humectant;
0.15-0.8% of a sun-screening agent;
1.2-3.0% of pearling agent;
0.3-0.8% of a softening conditioner;
0.15-0.4% of a neutralizer;
0.2-1.4% of a thickening agent;
0.6-2.8% of a nutrient;
0.15-0.8% of functional additive;
0.1-0.18% of preservative;
0.08-0.3% of essence;
the balance of water;
the total is 100%.
3. The repair and care shampoo containing periplaneta americana active ingredient according to claim 1 is characterized in that the preparation method of the horse chestnut fruit extract comprises the following steps: pulverizing horse chestnut fruit to minus 120 mesh, extracting with water as extraction solvent under rotary reflux for three times in a rotary evaporator, each time for 3.5-4.5 hr, wherein the mass of water used in the first and second extraction is 5.8-6.2 times of that of horse chestnut fruit; the water used for the third extraction accounts for 3.8-4.2 times of the fruit mass of horse chestnut, and the extractive solutions are combined and concentrated to obtain the final product.
4. The repair and care shampoo containing the periplaneta americana active ingredient according to claim 1, wherein the high molecular polymer is one or a combination of more of cationic guar gum, polyquaternium-10, xanthan gum, polyquaternium-39 and polyquaternium-7;
the chelating agent is one or two of ethylenediamine tetraacetic acid and disodium ethylenediamine tetraacetic acid.
5. The repair and care shampoo containing the periplaneta americana active ingredient according to claim 1, wherein the humectant is one or a combination of several of PEG-7M, glycerin, NMF-50, hyaluronic acid and ethylhexylglycerin;
the sun-screening agent is one or the combination of two of zinc oxide and titanium dioxide.
6. The repair and care shampoo containing periplaneta americana active ingredient according to claim 1 wherein the pearlizing agent is ethylene glycol distearate;
the neutralizer is one or more of triethanolamine, citric acid, sodium citrate and sodium hydroxide
7. The restoration and care shampoo containing periplaneta americana active ingredient according to claim 1, wherein the thickener is one or a combination of coconut oil diethanolamide, sodium chloride and 658 thickener; the nutritional agent is one or two of collagen and Periplaneta americana extract.
8. The repair and care shampoo containing periplaneta americana active ingredient according to claim 1, wherein the preservative is one or a combination of several of sodium benzoate, cason, benzoic acid, parachlorometaxylenol, triclocarban and potassium sorbate;
the essence is one or more of herba Menthae Rotundifoliae essence, semen Sesami essence, fructus Amomi rotundus essence, flos Chrysanthemi essence, flos Jasmini sambac essence, and herba Menthae essence; the water is deionized water.
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CN107970198B (en) * 2018-01-03 2021-05-07 昆明赛诺制药股份有限公司 Moistening and repairing hair conditioner containing periplaneta americana refined extract
CN109793700A (en) * 2019-04-04 2019-05-24 安徽省博禾功能食品有限公司 A kind of Bai Sangpi dandruff control shampoo containing
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CN114392223A (en) * 2022-01-19 2022-04-26 吉林省李婧健康产业有限公司 Active agent for repairing hair follicle and dredging stasis and blocking channels and collaterals

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