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CN110709425A - 一种结合bcma的嵌合抗原受体（car）及其应用 - Google Patents

一种结合bcma的嵌合抗原受体（car）及其应用 Download PDF

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Publication number
CN110709425A
CN110709425A CN201980002363.XA CN201980002363A CN110709425A CN 110709425 A CN110709425 A CN 110709425A CN 201980002363 A CN201980002363 A CN 201980002363A CN 110709425 A CN110709425 A CN 110709425A
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car
seq
cells
amino acid
cell
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CN110709425B (zh
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周剑峰
刘军建
胡广
杨永坤
孟广荣
高文静
王玉玉
牛盼盼
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Nanjing Reindeer Biotechnology Co ltd
Innovent Biologics Suzhou Co Ltd
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Nanjing Iaso Biotherapeutics Technology Co ltd
Innovent Biologics Suzhou Co Ltd
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Abstract

本申请提供了一种可以特异性结合BCMA蛋白的嵌合抗原受体(CAR)，其包含BCMA结合结构域、跨膜结构域、共刺激结构域和胞内信号传导结构域。本申请还提供了所述CAR在用于治疗与BCMA的表达相关的疾病或病症中的应用。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
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JP2021118736A (ja) 2021-08-12
EP3674328A4 (en) 2021-11-24
CA3074526C (en) 2021-08-03
EP3674328A1 (en) 2020-07-01
KR20200039793A (ko) 2020-04-16
TWI728308B (zh) 2021-05-21
PT3674328T (pt) 2024-03-14
KR102160061B1 (ko) 2020-09-29
ES2968880T3 (es) 2024-05-14
AU2019214163B2 (en) 2021-06-24
CN116082518A (zh) 2023-05-09
US20200376030A1 (en) 2020-12-03
EP3674328B1 (en) 2023-12-13
JP6968389B2 (ja) 2021-11-17
JP7246647B2 (ja) 2023-03-28
AU2019214163A1 (en) 2020-04-16
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JP2020536527A (ja) 2020-12-17
PL3674328T3 (pl) 2024-09-16

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