CN110464693A - Composition for splitting yeast tunning lysis object containing two and preparation method thereof and the application in cosmetics - Google Patents
Composition for splitting yeast tunning lysis object containing two and preparation method thereof and the application in cosmetics Download PDFInfo
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- CN110464693A CN110464693A CN201910877251.0A CN201910877251A CN110464693A CN 110464693 A CN110464693 A CN 110464693A CN 201910877251 A CN201910877251 A CN 201910877251A CN 110464693 A CN110464693 A CN 110464693A
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- tunning lysis
- yeast tunning
- splitting
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- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 238000005491 wire drawing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention belongs to cosmetic fields, more particularly to composition for containing two splitting yeast tunning lysis object and preparation method thereof and the application in cosmetics, yeast tunning lysis compositions are split including two, peptides composition, rice extract, the quality of each component is divided into: two mass fractions for splitting yeast tunning lysis object are 1-40 parts, 1-20 parts of peptides composition, the mass fraction of rice extract is 1-20 parts, the mass fraction for further including moisture-keeping composition is 1-20 parts, two, which split yeast tunning lysis compositions, splits yeast freeze-dried powder including two, two split yeast freeze-dried powder lyase liquid.Beneficial effects of the present invention: formula setting is reasonable, it is vdiverse in function, wrinkle can be significantly reduced, reduce pigment content, increase skin shine, bright color, increase skin elasticity, repair skin barrier, reduces water loss, it is non-stimulated to skin, have the function of preventing skin aging, lasting moisturizing simultaneously, skin is made to secure good health nature brilliant white state.
Description
Technical field
The invention belongs to cosmetic fields, more particularly to the composition and its system that split yeast tunning lysis object containing two
Preparation Method and the application in cosmetics.
Background technique
Skin is first of physiologic barrier of human body, and healthy skin can resist outside contamination, stimulation, damage and daylight
Infringement, while also there is moisturizing and adjustment effect.However, due to living environment, work and rest habit and skin care mode etc., skin
Barrier is easily impaired, so that skin self-defense scarce capacity, and then leads to that filament occurs in skin and wrinkle increases, elasticity lacks
It loses, sagging increases, solid sense missing, the uniformity (tonicity) of color lacks, surface texture is coarse and the pigmentation of plaque-like
Etc. a series of skin problems.
The annual sales volume of global Cosmetic Market is being doubled and redoubled, and brings considerable economic benefit.Functional form makeup
Product have become 21 generation with welcome of the multiple actions such as its anti-aging, whitening, sun-proof and moisturizing by modern, anti-aging cosmetics
The important development topic of discipline cosmetic industry.Some special enzymes and the cell played regulatory role during the metabolic cycles of cell
The factor plays a decisive role.
People extract from natural materials or go out some active materials with bionical method design and synthesis, thin to participate in
The composition of born of the same parents and metabolism, are repaired, substitution is impaired or the cell of aging, restrains or delays skin aging, keep the pale of skin with
Elasticity.
Currently, having anti-ageing and reparation cosmetics brand many in the market, effect is different, also deep by consumer's favorable rating
It is shallow different.But from source analysis that is anti-ageing and repairing, have plant origin with anti-ageing and restoration and protection skin, have and inhibits aging anti-
Oxidation pain protection skin also has the chemical synthesis preparation for resisting cell ageing.In the application, skin care item are usually in combination with using
Several anti-ageing and reparation substance, to reach anti-ageing and repairing effect.But many cosmetics do not have synergistic effect, so often
Optimal state is often not achieved.The physiology lysate that does not also obtain from Bifidobacterium repairs skin at present simultaneously, makes it
The cosmetics for the young state that maintains vigour.
Summary of the invention
For the above problem of solution, the present invention provides the composition for splitting yeast tunning lysis object containing two.
Technical solution of the present invention: the composition for splitting yeast tunning lysis object containing two, it is characterised in that including two
Split yeast tunning lysis compositions, peptides composition, rice extract.
Further, the quality of each component is divided into: two mass fractions for splitting yeast tunning lysis object are 1-40 parts, peptide
1-20 parts of class composition, the mass fraction of rice extract is 1-20 parts.
Further, described two to split yeast tunning lysis compositions include two splitting yeast freeze-dried powder, two splitting yeast
Freeze-dried powder lyase liquid.
Further, the peptides composition is carnosine and/or glutathione.
Further, the mass fraction for further including moisture-keeping composition is 1-20 parts.
Further, the moisture-keeping composition is poly- using low-molecular-weight hyaluronic acid, low-molecular-weight hyaluronic acid, oat Portugal
Sugar, D-pantothenyl aleohol, D-pantothenyl aleohol, composition one or more in deionized water；
The quality of each component is divided into: hyaluronic acid 1-10, oat beta-glucan 1-5, D-pantothenyl aleohol 3-5, Phenoxyethanol 3-5,
Deionized water 1-20.
Further, further include antioxidant composition, antioxidant composition using superoxide dismutase, protocatechuic acid,
One or more of ascorbic acid and algal polysaccharide.
The quality of each component is divided into: superoxide dismutase 1-10, protocatechuic acid 1-5 ascorbic acid 3-5, algal polysaccharide
1-20。
The preparation method for the composition for splitting yeast tunning lysis object containing two, it is characterised in that two, which split yeast fermentation, produces
Object lysis compositions, peptides composition, rice extract and optional glycerol be blended in 50 DEG C it is stirred below uniformly, obtain institute
State the composition that tool splits yeast tunning lysis object containing two.
Further, described two preparation method for splitting yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；S3: by two split yeast tunning lysis object, glutathione, Argireline, oligopeptides -1,
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by oligopeptides -3, mannitol mixing, is in 600r/min in revolving speed
10min is stirred, stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
Further, the preparation method of rice extract: rice, water and rice fermentation bacterium are mixed and carried out at rice fermentation
Reason, obtains rice fermentation liquid, is then sterilized, is centrifuged to rice fermentation liquid, obtain the rice extract.
The composition for splitting yeast tunning lysis object containing two is applied in preparing cosmetics, it is characterised in that
Added with the composition for splitting yeast tunning lysis object containing two in the cosmetics.
The medicine have the advantages that formula setting is rationally, wrinkle can be significantly reduced, reduce pigment content, increase skin light
Damp degree, bright color increase skin elasticity, repair skin barrier, reduce water loss, non-stimulated to skin, while having anti-
Only skin aging, lasting moisturizing effect, so that skin is secured good health nature brilliant white state.
Specific embodiment
Specific embodiment is explained below.
The composition for splitting yeast tunning lysis object containing two, it is characterised in that split yeast tunning lysis including two
Compositions, peptides composition, rice extract.
The quality of each component is divided into: two mass fractions for splitting yeast tunning lysis object are 1-40 parts, peptides composition
1-20 parts, the mass fraction of rice extract is 1-20 parts.
Two to split yeast tunning lysis compositions include two splitting yeast freeze-dried powder, two splitting yeast freeze-dried powder lyase liquid.
Two split yeast tunning lysis object releive repair Essence by addition Bifidobacterium extract, containing metabolism produce
Object, cytoplasmic components, cell-wall components and polysaccharide compound active constituent can prevent immunosuppressor interleukin (IL-10)
Release, while interleukin (IL-12) being prevented to be suppressed.Two, which split yeast tunning lysis object, can help epidermal cell and corium
Cell fights the adverse effect of UVB ray, keeps the integrality and vigor chrotoplast of cell, not only releives and repair skin, moreover it is possible to
Fight skin early ageing.
Peptides composition is carnosine and/or glutathione.
Wherein, being applied first in cosmetic formulations is two kinds of natural activity peptides: carnosine and glutathione, it is sun-proof,
It is used in crease-resistant and Skin whitening care cosmetics, effect is very good；On this basis, people have investigated again a plurality of types of peptides and by it
Applied in cosmetics.In general, a peptide, tripeptides, pentapeptide can help that collagen is promoted to generate；Tetrapeptide help it is anti-inflammatory,
It is anti-oxidant；The effect of hexapeptide can prevent neurotransmitter regulator, similar botulinum toxin.
N-BETA-Alanyl-L-histidine is added in cosmetics, can effectively slow down the aging of skin, play whitening function.It can prevent human body
Weathered human body cell is repaired in the growth of fibroblast, is the natural anti-aging of one kind, antioxidant；It is to freedom
Lipid oxidation caused by base and metal ion significantly inhibits], the active imidazole ring contained to metallic copper, iron from
The chelation of son is especially pronounced；It can enhance the light transmittance of muddy eye lens to treat cataract of old people；It can also promote
Wound healing inhibits tumour growth, currently, the acquisition modes of N-BETA-Alanyl-L-histidine have: natural extraction, protein hydrolysis, enzyme hydrolysis and change
Learn synthesis etc..
Glutathione can inhibit the generation of melanin, prevent skin aging, reduce pigmentation and improve skin antioxygen
Change ability has the effect of beauty treatment, beauty, skin care, moreover it is possible to prevent allergy；It is added in cosmetics, various skins can be suitble to, especially
There is good maintenance effect to responsive type skin.
The mass fraction for further including moisture-keeping composition is 1-20 parts.
Moisture-keeping composition is using one or more in hyaluronic acid, oat beta-glucan, D-pantothenyl aleohol, D-pantothenyl aleohol, deionized water
Composition；
The quality of each component is divided into: hyaluronic acid 1-4, oat beta-glucan 1-5, D-pantothenyl aleohol 3-5, Phenoxyethanol 3-5, go from
Sub- water 1-20.
Hyaluronic acid (hyaluronic acid, HA) is a kind of disaccharide list by glucuronic acid and n-acetylglucosamine
The glutinous polysaccharide that position repetition connects and composes, is widely present in the histocyte interstitial of animal and the pod membrane of certain bacteriums.HA its
The ceremonies such as medicine, cosmetics, food have extensive and unique application value.Especially in cosmetic field, HA is unrivaled with its
Skin sense, unique moisturizing activity and film forming, be widely used in terms of skin care item.People are to hyaluronic acid at present
Molecular weight be classified, referring to following table.
The skin-protecting function of HA depends primarily on molecular weight and dosage.The molecular weight of HA is bigger under normal circumstances, then intermolecular
Mutual winding effect it is bigger, wider array of molecular network can be formed, skin surface formed viscoplasticity film then have more preferably
Moisture-keeping efficacy.Low molecule HA molecular weight product range is in (20~40) ten thousand.
In cosmetics, HA dosage will generate molecular folding at 0.1% or more, form continuous three-dimensional network, produce
Raw various physiological effects, so 0.1% is that the effective of HA uses concentration.
It is higher than 2,000,000 HA using molecular weight, it is possible that wire drawing phenomenon, influences the texture of product in cosmetics.
Hyaluronic acid is the polysaccharide of unique not sulphation in naturally occurring glutinous polysaccharide, and hydrophily is strong, is unbranched line
Property molecule, is the naturally occurring component substances of skin, has high affinity with histocyte.The theory of Transdermal absorption is to build at present
Stand global molecular theoretically, compared with hyaluronic acid, the theory use molecular shape and tissue affinity there are larger
Difference is not suitable for the Transdermal absorption of hyaluronic acid.
The unique hydrophilic character and excellent histocompatbility, LMW HA of HA is applied in cosmetic field, can be effective
Exogenous HA is provided and increases skin HA concentration to skin corium, and improves the content of deep skin moisture content, helps to maintain skin
Ideal water content effectively improves the soft appropriateness and elasticity of skin.
Since LMW HA has preferable penetrating power, the formula of skin care field can be widely applied to
In, it is particularly suitable for moisturizing emulsion, cream, eye cream, in mask product, blood microcirculation can be promoted, adjust skin metabolism, change
Kind skin-nourishing, plays anti-wrinkle cosmetic, prevents skin aging.
LMW HA is used cooperatively with conventional molecular weight HA's, and the HA of conventional molecular weight can form moisturizing in epidermis
Film, LMW HA can penetrate into skin corium, can achieve the three-dimensional moistening effect from epidermis to corium.
Panthenol is widely used in the skin or hair care product of cosmetics as a kind of active matter.It can improve skin, head
The appearance of hair and nail.D-VB5 is the provitamin of D-VB5 (Panthenol).D-pantothenyl aleohol is sent out in the metabolism of human body
Crucial effect is waved.It is a component part of coacetylase.The shortage of Panthenol will lead to many cutaneous nerve disorders.
Oat is a kind of more drought-enduring, cold-resistant, resistance to lean, happiness cool place, the annual gramineae crop of long-day.It is main in the world
One of crops wanted.The high nutritive value of oat not only shows that it is rich in the nutritional ingredients such as protein, grease, more main
Further include antioxidant composition, antioxidant composition using superoxide dismutase, protocatechuic acid, ascorbic acid and
One or more of algal polysaccharide.
Wherein antioxidant composition is using one in superoxide dismutase, protocatechuic acid, ascorbic acid and algal polysaccharide
Kind is several.Prevent the dysgenic substance of oxygen.It is that one kind can help to capture and neutralize free radical, to dispel free radical
To a substance of human body damage.
Superoxide dismutase (Superoxide dismutase, SOD) is the important of Antioxidant Enzymes in biosystem
Forming member is widely distributed in microorganism, in plant and animal body.Skin aging and damage are the important features of human senility,
And human senility is since reactive oxygen species free radicals are accumulated or remove the consequence of generation obstacle, intracorporal extra free radical can cause
Cellular damage and pigmentation.Since the skin of people is directly contacted with oxygen, the aging and damage of skin will cause.External source
The supplement of SOD has conducive to delay skin aging, anti-oxidant, color spot of dispelling function.
Protocatechuic acid protocatechuic acid (Protocatechuic acid, PCA), i.e. 3,4- dihydroxy-benzoic acid, are naturally to deposit
It is one of many vegetables and fruit phenolic acid, and is effective work in many Chinese medicines (such as Radix Salviae Miltiorrhizae, lotus)
Property ingredient.Protocatechuic acid is a kind of water-soluble phenolic sour component, and is the active material of many Chinese medicines, not only has anti-blood small
Plate agglutination reduces myocardial oxygen consumption, improves the pharmacological activity such as myocardium oxygen-resistant ability, reducing heart rate, antibacterial, analgesia, also has anti-
Oxidation, antitumor and neuroprotection.
Ascorbic acid generally refers to vitamin C, and ascorbic structure is a kind of polyol similar to glucose,
The the 2nd and the 3rd upper two adjacent enolic hydroxyls easily dissociate and release H in molecule+, therefore there is the property of acid, it is also known as anti-
Bad hematic acid.Vitamin C has very strong reproducibility, it is easy to it is oxidized to dehydrogenation vitamin C, but its reaction is reversible, and
And ascorbic acid and hydroascorbic acid have same physiological function, if but hydroascorbic acid continue to aoxidize, generate diketone
Ancient happy saccharic acid, then react irreversible and lose physiological potency completely.
Algal polysaccharide is mainly from seaweed such as kelp, bulk kelp, yellow tang, bladder-wracks, including algin, fucoidin and brown
Algae starch.Excessive active oxygen radical has destruction to phagocyte itself and other cells, tissue and large biological molecule,
And lipid peroxidation accelerates that the destruction and death of normal cell can be caused.Algal polysaccharides not only have the work of Scavenger of ROS
With, additionally it is possible to the content of lipid peroxide (LPO) is significantly reduced, peroxidase (CAT) and superoxide dismutase are improved
(SOD) activity has the function of removing polyradical and anti peroxidation of lipid, and spirulina platensis polysaccharide can significantly increase machine
Body is anti-oxidant and the ability of free radical resisting damage, and mechanism may be by promoting body to SOD, GSH-Px (sweet skin mistake of paddy moon bright
Oxide enzyme) and GSH etc. biosynthesis and enhance the ability that body removes free radical.
The preparation method for the composition for splitting yeast tunning lysis object containing two splits yeast tunning lysis object for two
Composition, peptides composition, rice extract and optional glycerol be blended in 50 DEG C it is stirred below uniformly, obtain tool and split containing two
The composition of yeast tunning lysis object.
Two split the preparation method of yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；S3: by two split yeast tunning lysis object, glutathione, Argireline, oligopeptides -1,
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by oligopeptides -3, mannitol mixing, is in 600r/min in revolving speed
10min is stirred, stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
The preparation method of rice extract: rice, water and rice fermentation bacterium being mixed and carry out rice fermentation processing, obtained big
Rice fermentation liquid, then sterilizes to rice fermentation liquid, is centrifuged, obtain rice extract.
This method is effectively simplified production technology, carries out reaction process under mild conditions.Meanwhile it fermenting and extracting
Method also improves the effect of raw material, reduces toxicity and irritation, optimizes color and taste, is that a kind of comparatively ideal plant extract is new
Technique.
The composition for splitting yeast tunning lysis object containing two is applied in preparing cosmetics, it is characterised in that cosmetics
In added with the composition that splits yeast tunning lysis object containing two.
Compared with existing product, formula setting rationally, can significantly reduce wrinkle, reduce pigment content, increase skin gloss
Degree, bright color increase skin elasticity, repair skin barrier, reduce water loss, non-stimulated to skin, while having and prevent
Skin aging, lasting moisturizing effect, so that skin is secured good health nature brilliant white state.
Embodiment 1
The composition for splitting yeast tunning lysis object containing two, including two split yeast tunning lysis compositions,
Peptides composition, rice extract.
The quality of each component is divided into: two mass fractions for splitting yeast tunning lysis object are 1-40 parts, peptides composition
1-20 parts, the mass fraction of rice extract is 1-20 parts.
Two contents for splitting yeast tunning lysis object are 1-40 parts, for example, it may be 1 part, 3 parts, 6 parts, 10 parts, 12
Part, 15 parts, 17 parts, 20 parts, 21 parts, 23 parts, 26 parts, 29 parts, 30 parts, 31 parts, 33 parts, 36 parts, 39 parts, 40.
The content of Zinc-rich saccharomyces cerevisiae tunning filtrate is 1-20 parts, for example, it may be 1 part, 2 parts, 5 parts, 8 parts, 11 parts, 14
Part, 16 parts, 19 parts or 20 parts.
The content of rice extract is 1-20 parts, for example, it may be 1 part, 3 parts, 5 parts, 6 parts, 10 parts, 14 parts, 17 parts, 18
Part or 20 parts.
Rest part is the conventional adding ingredient of cosmetics in the prior art, for example, it may be glycerol or butanediol.
Embodiment 2
The composition for splitting yeast tunning lysis object containing two, including two split yeast tunning lysis compositions,
Peptides composition, rice extract, moisture-keeping composition
The quality of each component is divided into: two mass fractions for splitting yeast tunning lysis object are 1-40 parts, peptides composition
1-20 parts, the mass fraction of rice extract is 1-20 parts, and the mass fraction of moisture-keeping composition is 1-20 parts.
Two contents for splitting yeast tunning lysis object are 1-40 parts, for example, it may be 1 part, 3 parts, 6 parts, 10 parts, 12
Part, 15 parts, 17 parts, 20 parts, 21 parts, 23 parts, 26 parts, 29 parts, 30 parts, 31 parts, 33 parts, 36 parts, 39 parts, 40.
The content of Zinc-rich saccharomyces cerevisiae tunning filtrate is 1-20 parts, for example, it may be 1 part, 2 parts, 5 parts, 8 parts, 11 parts, 14
Part, 16 parts, 19 parts or 20 parts.
The content of rice extract is 1-20 parts, for example, it may be 1 part, 3 parts, 5 parts, 6 parts, 10 parts, 14 parts, 17 parts, 18
Part or 20 parts.
The content of moisture-keeping composition is 1-20 parts, for example, it may be 1 part, 3 parts, 5 parts, 6 parts, 10 parts, 14 parts, 17 parts, 18
Part or 20 parts.
Rest part is the conventional adding ingredient of cosmetics in the prior art, for example, it may be glycerol or butanediol.
Embodiment 3
The composition for splitting yeast tunning lysis object containing two, including two split yeast tunning lysis compositions,
Peptides composition, rice extract, moisture-keeping composition, antioxidant composition.
The quality of each component is divided into: two mass fractions for splitting yeast tunning lysis object are 1-40 parts, peptides composition
1-20 parts, the mass fraction of rice extract is 1-20 parts, and the mass fraction of moisture-keeping composition is 1-20 parts.
Two contents for splitting yeast tunning lysis object are 1-40 parts, for example, it may be 1 part, 3 parts, 6 parts, 10 parts, 12
Part, 15 parts, 17 parts, 20 parts, 21 parts, 23 parts, 26 parts, 29 parts, 30 parts, 31 parts, 33 parts, 36 parts, 39 parts, 40.
The content of Zinc-rich saccharomyces cerevisiae tunning filtrate is 1-20 parts, for example, it may be 1 part, 2 parts, 5 parts, 8 parts, 11 parts, 14
Part, 16 parts, 19 parts or 20 parts.
The content of rice extract is 1-20 parts, for example, it may be 1 part, 3 parts, 5 parts, 6 parts, 10 parts, 14 parts, 17 parts, 18
Part or 20 parts.
The content of moisture-keeping composition is 1-20 parts, for example, it may be 1 part, 3 parts, 5 parts, 6 parts, 10 parts, 14 parts, 17 parts, 18
Part or 20 parts.
The content of antioxidant composition be 1-20 parts, for example, it may be 1 part, 3 parts, 5 parts, 6 parts, 10 parts, 14 parts, 17 parts,
18 parts or 20 parts.
Rest part is the conventional adding ingredient of cosmetics in the prior art, for example, it may be glycerol or butanediol.
Embodiment 4
The preparation method for the composition for splitting yeast tunning lysis object containing two splits yeast tunning lysis object for two
Composition, peptides composition, rice extract and optional glycerol be blended in 50 DEG C it is stirred below uniformly, obtain tool and split containing two
The composition of yeast tunning lysis object.
Two split the preparation method of yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；S3: by two split yeast tunning lysis object, glutathione, Argireline, oligopeptides -1,
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by oligopeptides -3, mannitol mixing, is in 600r/min in revolving speed
10min is stirred, stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
The preparation method of rice extract: rice, water and rice fermentation bacterium being mixed and carry out rice fermentation processing, obtained big
Rice fermentation liquid, then sterilizes to rice fermentation liquid, is centrifuged, obtain rice extract.
The quality of water is 5-10 times of rice quality, for example, it may be 5 times, 6 times, 6.5 times, 7 times, 8 times or 10 times.
Rice fermentation bacterium is added in the form of bacterium solution.
Rice fermentation bacterium is saccharomycete, further preferably saccharomyces cerevisiae.
The quality of rice fermentation bacterium be rice and water mixed liquid quality 5-10%, for example, it may be 5%, 6%, 7%,
9% or 10%.
The bacterial concentration of rice fermentation bacterium is 10 6-10 8cfu/mL, for example, it may be 10 6cfu/mL, 10 7cfu/
ML or 10 8cfu/mL.
The temperature of rice fermentation processing is 25-35 DEG C, for example, it may be 25 DEG C, 27 DEG C, 29 DEG C, 30 DEG C, 32 DEG C, 34 DEG C
Or 35 DEG C；Time is 15-30 days, for example, it may be, 15 days, 16 days, 18 days, 20 days, 22 days, 25 days, 26 days, 28 days or 30
It.
When the pH value of rice fermentation liquid is 4-6, sterilization treatment is carried out.
This method is effectively simplified production technology, carries out reaction process under mild conditions.Meanwhile it fermenting and extracting
Method also improves the effect of raw material, reduces toxicity and irritation, optimizes color and taste, is that a kind of comparatively ideal plant extract is new
Technique.
Embodiment 5
The preparation method for the composition for splitting yeast tunning lysis object containing two splits yeast tunning lysis object for two
Composition, peptides composition, rice extract and optional glycerol be blended in 50 DEG C it is stirred below uniformly, obtain tool and split containing two
The composition of yeast tunning lysis object.Wherein two mass fractions for splitting yeast tunning lysis object are 1-40 parts, peptides
1-20 parts of composition, the mass fraction of rice extract is 1-20 parts.
Two split the preparation method of yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；S3: by two split yeast tunning lysis object, glutathione, Argireline, oligopeptides -1,
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by oligopeptides -3, mannitol mixing, is in 600r/min in revolving speed
10min is stirred, stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
The preparation method of peptides composition, peptides composition are carnosine and/or glutathione.
The acquisition modes of carnosine have: natural extraction, protein hydrolysis, enzyme hydrolysis and chemical synthesis etc..
The preparation method of carnosine composition is contracted after radical protection by acyl chlorides using Beta-alanine and L-Histidine as raw material
Closing reduction can be obtained.
Glutathione (Glutathione) is condensed by glutamic acid, cysteine and glycine through peptide bond, be containing
The polypeptide of active sulfydryl, it can be in conjunction with the free radical and peroxide in metabolism, moreover it is possible to the lipid peroxidation etc. of mitochondria is prevented,
Play the role of protecting cell resistance aging.
Glutathione preparation method, can be using direx process, chemical synthesis, fermentation method and enzyme transforming process etc..
Peptides composition can also use palmityl tripeptides -5, four victory peptide -5 of acetyl, pentapeptide, other than above-mentioned peptides,
Also there are several types of acetyl hexapeptide also known as argireline (Argireline), -1 (Snap- of eight victory peptide of acetyl for common polypeptide
8), both have the function of mitigating and caused wrinkle is shunk by facial expression muscle, especially reducing forehead and eye wrinkle-removing
Aspect, effect are ideal.Its mechanism of action is: block the conduction between muscle and nerve, loosen wrinkle, smooth dynamic line and
Expression line.Seven victory peptides are called one lipopeptid of beauty peptide (Lipopeptide Acetate), are famous whitening peptides, are not only making up
It is used to hinder the generation of melanin in product industry, improves the anti-sun damages ability of human body, moreover it can be used to is therapeutic in pharmaceuticals industry
The diseases such as dysfunction and cutaneum carcinoma.
Rice, water and rice fermentation bacterium are mixed and carry out rice fermentation processing by the preparation method of rice extract, are obtained big
Rice fermentation liquid, then sterilizes to rice fermentation liquid, is centrifuged, obtain rice extract.
The quality of water is 5-10 times of rice quality, for example, it may be 5 times, 6 times, 6.5 times, 7 times, 8 times or 10 times.
Rice fermentation bacterium is added in the form of bacterium solution.
Rice fermentation bacterium is saccharomycete, further preferably saccharomyces cerevisiae.
The quality of rice fermentation bacterium be rice and water mixed liquid quality 5-10%, for example, it may be 5%, 6%, 7%,
9% or 10%.
The bacterial concentration of rice fermentation bacterium is 10 6-10 8cfu/mL, for example, it may be 10 6cfu/mL, 10 7cfu/
ML or 10 8cfu/mL.
The temperature of rice fermentation processing is 25-35 DEG C, for example, it may be 25 DEG C, 27 DEG C, 29 DEG C, 30 DEG C, 32 DEG C, 34 DEG C
Or 35 DEG C；Time is 15-30 days, for example, it may be, 15 days, 16 days, 18 days, 20 days, 22 days, 25 days, 26 days, 28 days or 30
It.
When the pH value of rice fermentation liquid is 4-6, sterilization treatment is carried out.
This method is effectively simplified production technology, carries out reaction process under mild conditions.Meanwhile it fermenting and extracting
Method also improves the effect of raw material, reduces toxicity and irritation, optimizes color and taste, is that a kind of comparatively ideal plant extract is new
Technique.
Embodiment 6
The preparation method for the composition for splitting yeast tunning lysis object containing two splits yeast tunning lysis object for two
Composition, peptides composition, rice extract, moisture-keeping composition and optional glycerol be blended in 50 DEG C it is stirred below uniformly, obtain
The composition for splitting yeast tunning lysis object containing two to tool.Wherein two split yeast tunning lysis object mass fraction be
1-40 parts, 1-20 parts of peptides composition, the mass fraction of rice extract is 1-20 parts, the mass fraction of moisture-keeping composition is 1-
20 parts.
Two split the preparation method of yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；S3: by two split yeast tunning lysis object, glutathione, Argireline, oligopeptides -1,
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by oligopeptides -3, mannitol mixing, is in 600r/min in revolving speed
10min is stirred, stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
The preparation method of peptides composition, peptides composition are carnosine and/or glutathione.
The acquisition modes of carnosine have: natural extraction, protein hydrolysis, enzyme hydrolysis and chemical synthesis etc..
The preparation method of carnosine composition is contracted after radical protection by acyl chlorides using Beta-alanine and L-Histidine as raw material
Closing reduction can be obtained.
Glutathione (Glutathione) is condensed by glutamic acid, cysteine and glycine through peptide bond, be containing
The polypeptide of active sulfydryl, it can be in conjunction with the free radical and peroxide in metabolism, moreover it is possible to the lipid peroxidation etc. of mitochondria is prevented,
Play the role of protecting cell resistance aging.
Glutathione preparation method, can be using direx process, chemical synthesis, fermentation method and enzyme transforming process etc..
Peptides composition can also use palmityl tripeptides -5, four victory peptide -5 of acetyl, pentapeptide, other than above-mentioned peptides,
Also there are several types of acetyl hexapeptide also known as argireline (Argireline), -1 (Snap- of eight victory peptide of acetyl for common polypeptide
8), both have the function of mitigating and caused wrinkle is shunk by facial expression muscle, especially reducing forehead and eye wrinkle-removing
Aspect, effect are ideal.Its mechanism of action is: block the conduction between muscle and nerve, loosen wrinkle, smooth dynamic line and
Expression line.Seven victory peptides are called one lipopeptid of beauty peptide (Lipopeptide Acetate), are famous whitening peptides, are not only making up
It is used to hinder the generation of melanin in product industry, improves the anti-sun damages ability of human body, moreover it can be used to is therapeutic in pharmaceuticals industry
The diseases such as dysfunction and cutaneum carcinoma.
Rice, water and rice fermentation bacterium are mixed and carry out rice fermentation processing by the preparation method of rice extract, are obtained big
Rice fermentation liquid, then sterilizes to rice fermentation liquid, is centrifuged, obtain rice extract.
The quality of water is 5-10 times of rice quality, for example, it may be 5 times, 6 times, 6.5 times, 7 times, 8 times or 10 times.
Rice fermentation bacterium is added in the form of bacterium solution.
Rice fermentation bacterium is saccharomycete, further preferably saccharomyces cerevisiae.
The quality of rice fermentation bacterium be rice and water mixed liquid quality 5-10%, for example, it may be 5%, 6%, 7%,
9% or 10%.
The bacterial concentration of rice fermentation bacterium is 10 6-10 8cfu/mL, for example, it may be 10 6cfu/mL, 10 7cfu/
ML or 10 8cfu/mL.
The temperature of rice fermentation processing is 25-35 DEG C, for example, it may be 25 DEG C, 27 DEG C, 29 DEG C, 30 DEG C, 32 DEG C, 34 DEG C
Or 35 DEG C；Time is 15-30 days, for example, it may be, 15 days, 16 days, 18 days, 20 days, 22 days, 25 days, 26 days, 28 days or 30
It.
When the pH value of rice fermentation liquid is 4-6, sterilization treatment is carried out.
This method is effectively simplified production technology, carries out reaction process under mild conditions.Meanwhile it fermenting and extracting
Method also improves the effect of raw material, reduces toxicity and irritation, optimizes color and taste, is that a kind of comparatively ideal plant extract is new
Technique.
The preparation method of moisture-keeping composition uses the prior art.
Embodiment 7
The preparation method for the composition for splitting yeast tunning lysis object containing two splits yeast tunning lysis object for two
Composition, peptides composition, rice extract, moisture-keeping composition and optional glycerol be blended in 50 DEG C it is stirred below uniformly, obtain
The composition for splitting yeast tunning lysis object containing two to tool.Wherein two split yeast tunning lysis object mass fraction be
1-40 parts, 1-20 parts of peptides composition, the mass fraction of rice extract is 1-20 parts, the mass fraction of moisture-keeping composition is 1-
20 parts.
Two split the preparation method of yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing deionized water, the mannose by distillation and sterilization processing
Alcohol, oligopeptides -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione before carrying out mixing match
In vacuum packaging；
S2: yeast tunning lysis object, mannitol, glutathione, acetyl group six are split by quality proportioning weighed two
Peptide -8, oligopeptides -1, oligopeptides -3；S3: by two split yeast tunning lysis object, glutathione, Argireline, oligopeptides -1,
Mixture, is then placed in mixing plant and is at the uniform velocity stirred by oligopeptides -3, mannitol mixing, is in 600r/min in revolving speed
10min is stirred, stirring forms mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is 1200r/ in revolving speed
20min is stirred in min；
S5: mixed solution A is filtered by filter membrane, is removed impurity not soluble in water in mixed solution A and is mixed
Close solution B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, at this time temperature
Control carries out refrigeration operation, mixed solution B lyophilization after the completion of -15 DEG C, precooling, and temperature is controlled at -5 DEG C；
The preparation method of peptides composition, peptides composition are carnosine and/or glutathione.
The acquisition modes of carnosine have: natural extraction, protein hydrolysis, enzyme hydrolysis and chemical synthesis etc..
The preparation method of carnosine composition is contracted after radical protection by acyl chlorides using Beta-alanine and L-Histidine as raw material
Closing reduction can be obtained.
Glutathione (Glutathione) is condensed by glutamic acid, cysteine and glycine through peptide bond, be containing
The polypeptide of active sulfydryl, it can be in conjunction with the free radical and peroxide in metabolism, moreover it is possible to the lipid peroxidation etc. of mitochondria is prevented,
Play the role of protecting cell resistance aging.
Glutathione preparation method, can be using direx process, chemical synthesis, fermentation method and enzyme transforming process etc..
Peptides composition can also use palmityl tripeptides -5, four victory peptide -5 of acetyl, pentapeptide, other than above-mentioned peptides,
Also there are several types of acetyl hexapeptide also known as argireline (Argireline), -1 (Snap- of eight victory peptide of acetyl for common polypeptide
8), both have the function of mitigating and caused wrinkle is shunk by facial expression muscle, especially reducing forehead and eye wrinkle-removing
Aspect, effect are ideal.Its mechanism of action is: block the conduction between muscle and nerve, loosen wrinkle, smooth dynamic line and
Expression line.Seven victory peptides are called one lipopeptid of beauty peptide (Lipopeptide Acetate), are famous whitening peptides, are not only making up
It is used to hinder the generation of melanin in product industry, improves the anti-sun damages ability of human body, moreover it can be used to is therapeutic in pharmaceuticals industry
The diseases such as dysfunction and cutaneum carcinoma.
Rice, water and rice fermentation bacterium are mixed and carry out rice fermentation processing by the preparation method of rice extract, are obtained big
Rice fermentation liquid, then sterilizes to rice fermentation liquid, is centrifuged, obtain rice extract.
The quality of water is 5-10 times of rice quality, for example, it may be 5 times, 6 times, 6.5 times, 7 times, 8 times or 10 times.
Rice fermentation bacterium is added in the form of bacterium solution.
Rice fermentation bacterium is saccharomycete, further preferably saccharomyces cerevisiae.
The quality of rice fermentation bacterium be rice and water mixed liquid quality 5-10%, for example, it may be 5%, 6%, 7%,
9% or 10%.
The bacterial concentration of rice fermentation bacterium is 10 6-10 8cfu/mL, for example, it may be 10 6cfu/mL, 10 7cfu/
ML or 10 8cfu/mL.
The temperature of rice fermentation processing is 25-35 DEG C, for example, it may be 25 DEG C, 27 DEG C, 29 DEG C, 30 DEG C, 32 DEG C, 34 DEG C
Or 35 DEG C；Time is 15-30 days, for example, it may be, 15 days, 16 days, 18 days, 20 days, 22 days, 25 days, 26 days, 28 days or 30
It.
When the pH value of rice fermentation liquid is 4-6, sterilization treatment is carried out.
This method is effectively simplified production technology, carries out reaction process under mild conditions.Meanwhile it fermenting and extracting
Method also improves the effect of raw material, reduces toxicity and irritation, optimizes color and taste, is that a kind of comparatively ideal plant extract is new
Technique.
Moisture-keeping composition is using one or more in hyaluronic acid, oat beta-glucan, D-pantothenyl aleohol, D-pantothenyl aleohol, deionized water
Composition；The preparation method of moisture-keeping composition uses the prior art.
Embodiment 8
The preparation method for the composition for splitting yeast tunning lysis object containing two splits yeast tunning lysis object for two
Composition, peptides composition, rice extract, moisture-keeping composition, antioxidant composition and optional glycerol be blended in 50 DEG C with
Under stir evenly, obtain having the composition for splitting yeast tunning lysis object containing two.Wherein two split yeast tunning lysis
The mass fraction of object is 1-40 parts, and 1-20 parts of peptides composition, the mass fraction of rice extract is 1-20 parts, moisture-keeping composition
Mass fraction be 1-20 parts, antioxidant composition 1-30.
Antioxidant composition using one of superoxide dismutase, protocatechuic acid, ascorbic acid and algal polysaccharide or
It is several.The preparation method of antioxidant composition uses the prior art.
Embodiment 9
The composition for splitting yeast tunning lysis object containing two is applied in preparing cosmetics, it is characterised in that cosmetics
In added with the composition that splits yeast tunning lysis object containing two.
Cosmetics are toner facial mask, Essence, face cream, lotion etc..
Example of the invention is described in detail above, but content is only presently preferred embodiments of the present invention, it cannot be by
Think for limiting practical range of the invention.Any changes and modifications in accordance with the scope of the present application, should all be still
It falls within the scope of the patent of the present invention.
Claims (10)
1. the composition for splitting yeast tunning lysis object containing two, it is characterised in that split yeast tunning lysis object including two
Composition, peptides composition, rice extract.
2. the composition according to claim 1 for splitting yeast tunning lysis object containing two, it is characterised in that each component
Quality be divided into: two split yeast tunning lysis object mass fractions be 1-40 part, 1-20 parts of peptides composition, rice extraction
The mass fraction of object is 1-20 parts.
3. the composition according to claim 1 or 2 for splitting yeast tunning lysis object containing two, it is characterised in that described
Two to split yeast tunning lysis compositions include two splitting yeast freeze-dried powder, two splitting yeast freeze-dried powder lyase liquid.
4. the composition according to claim 1 or 2 for splitting yeast tunning lysis object containing two, it is characterised in that described
Peptides composition is carnosine and/or glutathione.
5. the composition according to claim 1 or 2 for splitting yeast tunning lysis object containing two, it is characterised in that also wrap
The mass fraction for including moisture-keeping composition is 1-20 parts.
6. the composition according to claim 3 for splitting yeast tunning lysis object containing two, it is characterised in that further include
The moisture-keeping composition is using group one or more in hyaluronic acid, oat beta-glucan, D-pantothenyl aleohol, D-pantothenyl aleohol, deionized water
Close object；
The quality of each component is divided into: hyaluronic acid 1-10, oat beta-glucan 1-5, D-pantothenyl aleohol 3-5, Phenoxyethanol 3-5, go from
Sub- water 1-20.
Preferably.It further include antioxidant composition, antioxidant composition uses superoxide dismutase, protocatechuic acid, Vitamin C
One or more of acid and algal polysaccharide.
The quality of each component is divided into: superoxide dismutase 1-10, protocatechuic acid 1-5 ascorbic acid 3-5, algal polysaccharide 1-
20。
7. the preparation method of -6 any compositions for splitting yeast tunning lysis object containing two according to claim 1,
It is mixed it is characterized in that splitting yeast tunning lysis compositions, peptides composition, rice extract for two with optional glycerol
Conjunction is stirred below uniform at 50 DEG C, obtains the composition for having and splitting yeast tunning lysis object containing two.
8. the preparation method of the composition according to claim 7 for splitting yeast tunning lysis object containing two, feature
It is described two preparation methods for splitting yeast tunning lysis object, comprising the following steps:
S1: it the selection of raw material and prepares ratio: choosing by distillation and the deionized water of sterilization processing, mannitol, widow
Peptide -1, oligopeptides -3, Argireline, two split yeast tunning lysis object, glutathione is in front of carrying out mixing match
Vacuum packaging；
S2: by quality proportioning weighed two split yeast tunning lysis object, mannitol, glutathione, Argireline,
Oligopeptides -1, oligopeptides -3；S3: yeast tunning lysis object, glutathione, Argireline, oligopeptides -1, oligopeptides-are split by two
3, mannitol mixes, and then mixture is placed in mixing plant and is at the uniform velocity stirred, and is to stir in 600r/min in revolving speed
10min, stirring form mixed solution A；
S4: mixed solution A standing being again placed in mixing plant afterwards for 24 hours and is at the uniform velocity stirred, and is in 1200r/min in revolving speed
Stir 20min；
S5: mixed solution A is filtered by filter membrane, and impurity not soluble in water obtains mixing molten in removing mixed solution A
Liquid B；
S6: mixed solution B is placed in sterilizing Dewar bottle and is vacuum-packed, storage temperature is controlled at 5 DEG C or less；
S7: mixed solution B being placed in centrifugation apparatus and carries out centrifugally operated, then carries out precooling operation, and temperature controls at this time
Refrigeration operation, mixed solution B lyophilization are carried out after the completion of -15 DEG C, precooling, temperature is controlled at -5 DEG C；
9. the preparation method of the composition according to claim 7 for splitting yeast tunning lysis object containing two, feature
It is the preparation method of rice extract: rice, water and rice fermentation bacterium is mixed and carry out rice fermentation processing, obtains rice hair
Then zymotic fluid sterilizes to rice fermentation liquid, is centrifuged, the rice extract is obtained.
10. -9 any compositions for splitting yeast tunning lysis object containing two are made up in preparation according to claim 1
It is applied in product, it is characterised in that added with the composition for splitting yeast tunning lysis object containing two in the cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910877251.0A CN110464693A (en) | 2019-09-17 | 2019-09-17 | Composition for splitting yeast tunning lysis object containing two and preparation method thereof and the application in cosmetics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910877251.0A CN110464693A (en) | 2019-09-17 | 2019-09-17 | Composition for splitting yeast tunning lysis object containing two and preparation method thereof and the application in cosmetics |
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| Publication Number | Publication Date |
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| CN110464693A true CN110464693A (en) | 2019-11-19 |
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| CN111214417A (en) * | 2020-03-10 | 2020-06-02 | 广州澳特朗生物技术有限公司 | Yeast essence with effects of tightening and resisting wrinkles and preparation method and application thereof |
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| CN111920723A (en) * | 2020-09-15 | 2020-11-13 | 广州莱约生物科技有限公司 | Moisturizing composition and preparation method and application thereof |
| CN111920723B (en) * | 2020-09-15 | 2023-04-28 | 广州莱约生物科技有限公司 | Moisturizing composition, preparation method and application thereof |
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| CN113520926A (en) * | 2021-08-19 | 2021-10-22 | 浙江予美生物科技有限公司 | Composition for skin anti-aging, preparation method, cosmetic and application |
| CN113520926B (en) * | 2021-08-19 | 2023-11-28 | 浙江予美生物科技有限公司 | Composition for skin anti-aging, preparation method, cosmetics and application |
| CN114073658A (en) * | 2021-11-23 | 2022-02-22 | 湖北省麦诗特生物科技有限公司 | Essence composition containing liposome capable of resisting photoaging damage and preparation method thereof |
| CN114073658B (en) * | 2021-11-23 | 2023-09-15 | 湖北省麦诗特生物科技有限公司 | Essence composition containing liposome capable of resisting photoaging injury and preparation method thereof |
| CN114259457A (en) * | 2022-01-12 | 2022-04-01 | 江西灏洋生物科技有限公司 | Skin care product containing yeast fermentation related product and preparation method thereof |
| CN116590169A (en) * | 2022-12-15 | 2023-08-15 | 东莞华工创为生物科技有限公司 | Bifidobacterium longum and application thereof |
| CN116590169B (en) * | 2022-12-15 | 2024-01-30 | 东莞华工创为生物科技有限公司 | Bifidobacterium longum and application thereof |
| FR3145489A1 (en) | 2023-02-04 | 2024-08-09 | Terrake France | Cosmetic composition for hair care combining a Sturgeon Caviar extract and a Bifidus lysate with six different plant extracts to maintain the entire hair in good condition. |
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Application publication date: 20191119 |