CN1090920C - Kelp product and its production method and application - Google Patents
Kelp product and its production method and application Download PDFInfo
- Publication number
- CN1090920C CN1090920C CN99116164A CN99116164A CN1090920C CN 1090920 C CN1090920 C CN 1090920C CN 99116164 A CN99116164 A CN 99116164A CN 99116164 A CN99116164 A CN 99116164A CN 1090920 C CN1090920 C CN 1090920C
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- CN
- China
- Prior art keywords
- extract
- product
- thallus
- kelp
- molecular weight
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000512259 Ascophyllum nodosum Species 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 239000012528 membrane Substances 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000000047 product Substances 0.000 claims description 22
- 238000007598 dipping method Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000004365 Protease Substances 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 6
- 230000002557 soporific effect Effects 0.000 claims description 6
- 239000000287 crude extract Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 108091005804 Peptidases Proteins 0.000 claims description 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 4
- 230000001914 calming effect Effects 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 239000000932 sedative agent Substances 0.000 abstract description 3
- 230000001624 sedative effect Effects 0.000 abstract description 3
- 239000012535 impurity Substances 0.000 abstract description 2
- 231100000252 nontoxic Toxicity 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 238000000108 ultra-filtration Methods 0.000 abstract description 2
- 230000000147 hypnotic effect Effects 0.000 abstract 2
- 238000002791 soaking Methods 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 9
- 229960000796 barbital sodium Drugs 0.000 description 5
- FTOAOBMCPZCFFF-UHFFFAOYSA-N barbitone sodium Natural products CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000019419 proteases Nutrition 0.000 description 3
- 239000000470 constituent Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000019834 papain Nutrition 0.000 description 2
- 230000008925 spontaneous activity Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001466453 Laminaria Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000015177 Saccharina japonica Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000004799 sedative–hypnotic effect Effects 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Edible Seaweed (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
一种海带制品及其制作方法和用途，本发明以海带为原料，经热浸、酶解后，用超滤膜截取分离其中分子量在4000-70000道尔顿之间的部分，再经纯化去杂质后取得其提取物，可将其制成口服液、片剂或胶囊形式即为本海带制品。本海带制品安全无毒，具有良好的镇静安眠作用，可作镇静安眠的药用保健品用途。A kelp product and its production method and application. The invention uses kelp as a raw material. After hot-soaking and enzymolysis, ultrafiltration membranes are used to intercept and separate the part with a molecular weight between 4000-70000 Daltons, and then purify to remove After removing impurities, its extract can be made into oral liquid, tablet or capsule, which is the kelp product. The kelp product is safe and non-toxic, has a good sedative and hypnotic effect, and can be used as a medicinal health care product for sedative and hypnotic.
Description
The present invention relates to a kind of is the kelp product and preparation method thereof and its new purposes of raw material with the Thallus Laminariae (Thallus Eckloniae).
Thallus Laminariae (Thallus Eckloniae) (Laminaria japonica Aresch) is the marine product that a kind of people are familiar with, contain polysaccharide, protein, crude fibre, several amino acids and iodine, traditional usage is a shredding airing or to fry in shallow oil soup edible, as general food or the refrigerant diuresis food or the food that enriches the iodine.
The objective of the invention is to propose a main laminaria and be the kelp product and preparation method thereof and new purposes of raw material, these goods have the natural constituent of Thallus Laminariae (Thallus Eckloniae), have the medicinal and health-care effect of calming soporific.
The present invention is a kind of like this goods, it is raw material with the Thallus Laminariae (Thallus Eckloniae), separates and suitable purification process through hot dipping, enzymolysis, intercepting, and the extract of gained is made tablet, capsule or oral liquid, product is light brown, and the molecular weight ranges of said extract is 4000-70000 dalton.
Essence of the present invention is the extraction to Thallus Laminariae (Thallus Eckloniae) raw material natural constituent, and after the Thallus Laminariae (Thallus Eckloniae) raw material was carried out hot dipping, enzymolysis, the arbitrary section part of molecular weight between 4000-70000 dalton was as extract in its extract of intercepting separation.Though the part of any section of molecular weight in 4000-70000 dalton scope all contains the necessary composition of goods of the present invention in the above-mentioned said extract, the preferred molecular weight area segment limit of its effective ingredient is between 15000-45000 dalton.
Goods of the present invention manufacture method may further comprise the steps:
(1), with the sufficiently long time after-filtration of Thallus Laminariae (Thallus Eckloniae) raw material hot dipping, get filtrate as crude extract, the hot dipping temperature is 50 ℃-99 ℃, best hot dipping temperature range is 80-95 ℃;
(2), crude extract concentrated after, add the protease hydrolyzed after-filtration, the filtrate of its enzymolysis solution;
(3), intercept in the filtrate of above-mentioned enzymolysis solution molecular weight ranges at the daltonian part of the 4000-70000 extract that is as the criterion with ultrafilter membrane;
(4), in accurate extract, add edible ethanol, control solution concentration of alcohol (volume ratio) makes to produce precipitation in the 60%-90% scope, and is centrifugal then, gets its precipitate, promptly obtains to prepare the Thallus Laminariae (Thallus Eckloniae) extract of said kelp product.
Obtain after the above-mentioned Thallus Laminariae (Thallus Eckloniae) extract, can make drink form or tablet form or capsule form by general conventional method as required.For example above-mentioned precipitate is dried under vacuum condition and add suitable additives then and make tablet or capsule; Or said extract directly is mixed with oral liquid.
Above-mentioned steps (4) is the removal of impurity purification process process to extract.
Carry out hot dipping again after the Thallus Laminariae (Thallus Eckloniae) raw material powder can being broken into kelp paste, to improve the leaching effect of Thallus Laminariae (Thallus Eckloniae) effective ingredient.
The protease of the said crude extract of enzymolysis can adopt neutral enzymatic or acidicenzym, and as the protease of papain, bromelain or other kinds, conditions such as the temperature of enzymolysis are decided according to used enzyme characteristic.
With the concrete grammar of the filtrate of the said enzymolysis solution of ultrafiltration membrane treatment is molecular weight ranges according to the said accurate extract of preparing to obtain, the filtrate of said enzymolysis solution is intercepted at the ultrafilter membrane of the lower limit of said molecular weight ranges and higher limit with the aperture respectively and separates, get final product said accurate extract.
The present invention adopts modern scientific method, and the pharmaceutical components in the Thallus Laminariae (Thallus Eckloniae) raw material is carried out separation and Extraction, prepared kelp product safety non-toxic, and the reliable easily row of its preparation method, suitable for mass production, free from environmental pollution, cost is low.
An important feature of this kelp product is the effect with tangible calming soporific, and is natural product, and the effect of existing health food has medicinal value again, thereby can be used as the medicinal health product of calming soporific.
This kelp product carries out the test of animal (white mice) tranquilizing soporific through No.1 Mmilitary Medical University, Chinese PLA, and result of the test is as follows:
Medicine (this kelp product with normal saline be mixed with the test desired concn solution) to the influence of spontaneous activity in mice
| Group (every group of 10 mices) | Route of administration | Dosage (the g crude drug/kg) | Movable number of times before the administration (inferior/min) | Movable number of times after the administration (inferior/min) |
| The blank group | ig | 0 | 288+63.7 | 285+64.3 |
| Low dose group | ig | 0.126 | 268±50.3 | 258+112.8 |
| Middle dosage group | ig | 0.25 | 274±46.8 | 228+115.9 |
| High dose group (1) | ig | 0.51 | 281±71.9 | 186±83.0 |
| High dose group (2) | ig | 1.01 | 300±125.9 | 96±36.9 |
2. medicine causes the sleeping influence of mice to sleep dosage under the barbital sodium valves
| Group | The mice number (every group of 20 mices) (barbital sodium 30mg/kg) of falling asleep | Mouse sleep time (every group of 10 mices) (barbital sodium 50mg/kg) |
| The blank group | 0 | 16.3±3.34 |
| Low dose group | 1 | 17.2±4.04 |
| Middle dosage group | 4 | 22.5±5.52 |
| High dose group (1) | 7 | 27.9±5.93 |
| High dose group (2) | 10 | 32.4±7.68 |
Can find out that by experimental result this kelp product can obviously reduce the spontaneous activity number of times of white mice, has showed certain sedation; The number of mice that can increase sleep inducing under the barbital sodium threshold also can prolong the length of one's sleep of barbital sodium, and this effect is strengthened with the increase of dosage.Thereby show that this kelp product has tangible sedative-hypnotic property.
The embodiment of producing this kelp product is as follows:
Get 10 kilograms in Thallus Laminariae (Thallus Eckloniae), clean, be ground into kelp paste; Add 200 kg of water, constant temperature stirred 180 minutes under 80 ℃ of temperature; Filter, filtrate is concentrated into 50 kilograms; Add 8 gram papains, enzymolysis is 30 minutes under 60 ℃ of temperature, be warming up to then 95 ℃ 10 minutes; Filter, getting filtrate is that 6000 daltonian ultrafilter membranes (aperture of ultrafilter membrane is 6000 dalton) intercept separation with the intercepting molecular weight, gets the intercepting molecular weight greater than 6000 dalton's parts, is secondary extract; Is that 70000 daltonian ultrafilter membranes intercept separation with secondary extract with the intercepting molecular weight, gets the intercepting molecular weight less than 70000 dalton's parts, gets accurate extract; Get accurate extract, edible ethanol to the solution concentration of alcohol (volume ratio) of adding 95% is 80%, and is centrifugal, taking precipitate; Precipitate is dried under the evacuation condition to water content≤5%, make tablet or capsule (also precipitate directly can be deployed into oral liquid) by conventional method again.
The prepared kelp product of this law is a light brown.Edible about 100 milligrams of every day, has the good sedative soporific function.
Claims (5)
1. kelp product, it is characterized in that with the Thallus Laminariae (Thallus Eckloniae) being raw material, separate and suitable purification process, the extract of gained is made tablet, capsule or oral liquid through hot dipping, enzymolysis, intercepting, product is light brown, and the molecular weight ranges of said extract is 4000-70000 dalton.
2. by the described kelp product of claim 1, the molecular weight that it is characterized in that said extract is between 15000-45000 dalton.
3. the manufacture method of the described kelp product of claim 1 is characterized in that may further comprise the steps:
(1), with the sufficiently long time after-filtration of Thallus Laminariae (Thallus Eckloniae) raw material hot dipping, get filtrate as crude extract, the hot dipping temperature is 50 ℃-99 ℃;
(2), crude extract concentrated after, add the protease hydrolyzed after-filtration, the filtrate of its enzymolysis solution;
(3), intercept in the filtrate of above-mentioned enzymolysis solution the part of molecular weight ranges between the 4000-70000 dalton extract that is as the criterion with ultrafilter membrane;
(4), in accurate extract, add edible ethanol, control solution concentration of alcohol (volume ratio) makes to produce precipitation in the 60%-90% scope, and is centrifugal then, gets its precipitate, Thallus Laminariae (Thallus Eckloniae) extract;
(5), the Thallus Laminariae (Thallus Eckloniae) extract of obtaining is made tablet, capsule or oral liquid.
4. by the manufacture method of the described kelp product of claim 3, carry out hot dipping again after it is characterized in that the Thallus Laminariae (Thallus Eckloniae) raw material powder is broken into kelp paste.
5. the purposes of the described kelp product of claim 1 is the medicinal health product as calming soporific.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116164A CN1090920C (en) | 1999-05-04 | 1999-05-04 | Kelp product and its production method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116164A CN1090920C (en) | 1999-05-04 | 1999-05-04 | Kelp product and its production method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1272336A CN1272336A (en) | 2000-11-08 |
| CN1090920C true CN1090920C (en) | 2002-09-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99116164A Expired - Lifetime CN1090920C (en) | 1999-05-04 | 1999-05-04 | Kelp product and its production method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1090920C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106349298A (en) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | Application of sodium alginate oligose and derivative to improvement of sleep disorders |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012086853A1 (en) * | 2010-12-20 | 2012-06-28 | Korea Food Research Institute | Composition for positively allosterically modulating gabaa-benzodiazepine receptor and composition for producing sedative-hypnotic effects containing ecklonia cava extract and ecklonia kurome extract |
| CN103070431B (en) * | 2012-08-22 | 2013-11-27 | 浙江省海洋开发研究院 | Kelp extract iodine tablet and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86105774A (en) * | 1986-07-19 | 1988-02-17 | 南京大学 | The extracting method and the technology of the edible digestive juice of sea-tangle |
| CN1078358A (en) * | 1993-01-06 | 1993-11-17 | 曾子荣 | A kind of nutriment of producing by natural plants and preparation method thereof |
| CN1105540A (en) * | 1994-11-03 | 1995-07-26 | 大连海藻保健食品厂 | Natural plant extracted liquid and its use |
| CN1172609A (en) * | 1996-12-20 | 1998-02-11 | 车旭华 | Method for preparing iodine enriched nutritive liquor |
-
1999
- 1999-05-04 CN CN99116164A patent/CN1090920C/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86105774A (en) * | 1986-07-19 | 1988-02-17 | 南京大学 | The extracting method and the technology of the edible digestive juice of sea-tangle |
| CN1078358A (en) * | 1993-01-06 | 1993-11-17 | 曾子荣 | A kind of nutriment of producing by natural plants and preparation method thereof |
| CN1105540A (en) * | 1994-11-03 | 1995-07-26 | 大连海藻保健食品厂 | Natural plant extracted liquid and its use |
| CN1172609A (en) * | 1996-12-20 | 1998-02-11 | 车旭华 | Method for preparing iodine enriched nutritive liquor |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106349298A (en) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | Application of sodium alginate oligose and derivative to improvement of sleep disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1272336A (en) | 2000-11-08 |
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