CN108836909A

CN108836909A - A kind of preparation method of the anti-wrinkle Essence containing gadol extract

Info

Publication number: CN108836909A
Application number: CN201810831874.XA
Authority: CN
Inventors: 卜俊超
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-07-26
Filing date: 2018-07-26
Publication date: 2018-11-20

Abstract

A kind of preparation method of the anti-wrinkle Essence containing gadol extract, belongs to Essence preparation technical field, including：Gadol extract, preparation small molecule collagen polypeptide extracting solution, the preparation of water phase liquid are prepared, is emulsified, cool down and etc..The present invention is added in cosmetics using gadol extract as plant additive, has effects that excellent anti-wrinkle is crease-resistant.Collagen and polypeptide can provide energy for skin, adjust intracorporal moisture, promote the synthesis and regulation of protein, enzyme, facilitate metabolism, promote cell Proliferation, differentiation, can repair cell, crease-resistant, anti-oxidant and anti-aging.

Description

A kind of preparation method of the anti-wrinkle Essence containing gadol extract

Technical field

The present invention relates to Essence preparation technical field, in particular to a kind of anti-wrinkle Essence containing gadol extract Preparation method.

Background technique

Essence is the superfine product in skin care item, and ingredient is exquisite, effect is powerful, significant effect, remains what it possessed It is noble and mysterious, it is suitable for any skin or inclined oily skin, preferably puts in the vial, take at any time.Essence is used for toner Later, before face cream.Commonly there is poor permeability, be not easy the problems such as absorbing, and single effect in current Essence, functional It is not strong.

Summary of the invention

The anti-wrinkle essence containing gadol extract that it is an object of the invention to overcome the deficiencies of the prior art and provide a kind of The effect of preparation method of liquid has good penetrability, easily absorbs, anti-wrinkle.

The present invention uses following technical scheme：

A kind of preparation method of the anti-wrinkle Essence containing gadol extract, includes the following steps：

Step 1：Root of kirilow rhodiola is cleaned, is placed at shady and cool ventilation 2-4 days, then be placed in crock, root of kirilow rhodiola weight 2-4 is added Rice vinegar again, sealing is 3-6 hours stewing, and filtering, filter residue is placed on the iron plate heated, dries 10-20 minutes, cools to room temperature, grinds 120-140 mesh is crossed at smalls, gains are added to 3-6 times of raw material weight of deionized water, and heating mixing while stirring, temperature It is sufficiently stirred and is uniformly dissolved at 50-70 DEG C of degree, rose hip oil is added when cooling the temperature to 30-40 DEG C, after mixing evenly in 140- It sterilizes 20-40 seconds at 150 DEG C, is cooled to 20 DEG C, obtains gadol extract；

Step 2：It is first impregnated fish-skin bone 30 seconds with the ethyl alcohol of mass concentration 60-80%, then is carefully cleaned with clear water, removed Fats impurity cuts disrupting tissue with knife later, and water elutes 3 times, then presses fish-skin bone and water quality than 1:5 ratio impregnates fish-skin Bone adjusts pH value to 6.9-8.5, is heated to 100 degree, keeps the temperature 1 hour, be cooled to water temperature 40-50 degree, use 150- later 300 mesh filter 2-3 times, obtain macromolecular collagen protein extracting solution, and wherein collagen content is 0.05-1g/ml；

Step 3：Macromolecular collagen protein extracting solution is digested with biological enzyme, biological enzyme used is stomach cardia Enzyme, concentration 0.0001-500mg/ml digest within 24 hours, are put into 90 DEG C of water-baths and be cooled to room temperature after destroying enzyme activity, from Heart processing, 4500-10000rpm are centrifugated 30-10min, finally take supernatant, obtain small molecule collagen polypeptide extracting solution, Middle collagen polypeptide content is 0.05-1g/ml；

Step 4：It weighs in deionized water to water phase pot, sequentially adds the measured EDETATE SODIUM of accurate scale, hyaluronic acid Sodium, carbomer, and heating mixes while stirring, is sufficiently stirred and is uniformly dissolved under temperature 60 C, sequentially adds propylene glycol, 1,3- Butanediol, methyl hydroxybenzoate, allantoin, temperature 60 C keep the temperature 30 minutes；

Step 5：Material in water phase pot is pumped into vacuum emulsifying pot, root of kirilow rhodiola is sequentially added under stirring and mentions Take object, small molecule collagen polypeptide extracting solution, propolis extract, protease, aminopeptidase, camomile extract, licorice, Yeast polypeptides, tip edge bladder-wrack extract, oligopeptides -20 stir 30 minutes, are sufficiently mixed uniformly；

Step 6：It cools, when temperature drops to 45 DEG C, Cremophor RH40, blumea oil, octanoic acid is added Glyceride, and stir；

Step 7：Continue to cool down, when temperature drops to 35 DEG C, aminomethyl propanol is added, and stir, then cold But to room temperature to get Essence.

Preferably, the propolis extract is nanometer supercritical bee-glue.

It is further preferred that the nanometer supercritical bee-glue is the nanometer being process by Phospholipids nano-encapsulated technology Supercritical bee-glue.

Preferably, the licorice is prepared using following methods：5g licorice medicinal materials are crushed, sieving, obtains powder The NaOH aqueous solution that concentration is 0.2mol/L is added in body, is 1 by solid-to-liquid ratio:The mixing of 10 ratios, 2h is extracted in hot dipping at 80 DEG C, It is repeated 2 times, filters, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifuged under the revolving speed of 4000r/min Separation, goes supernatant to obtain sediment, as licorice.

Preferably, the camomile extract is prepared using following methods：5g chamomile is crushed, sieving, obtains powder The NaOH aqueous solution that concentration is 0.2mol/L is added in body, is 1 by solid-to-liquid ratio:The mixing of 10 ratios, 2h is extracted in hot dipping at 80 DEG C, It is repeated 2 times, filters, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifuged under the revolving speed of 4000r/min Separation, goes supernatant to obtain sediment, as camomile extract.

Preferably, the tip edge bladder-wrack extract is prepared using following methods：Tip edge bladder-wrack is washed, is put It sets and is carried out at aeration-drying air-dried, the tip edge bladder-wrack after air-drying is placed in micro-wave oven, the dry 4min of moderate heat, after drying Tip edge bladder-wrack be put into pulverizer and crush, smashed tip edge bladder-wrack is crossed into 60 meshes, tip edge bladder-wrack powder is obtained, weighs Tip edge bladder-wrack powder 10g, deionized water 100g, are added to the container, and decoct at 90 DEG C and extract 100min, by the substance in container It all takes out, is cooled to room temperature, filtered with cryogenic freezing centrifuge, revolving speed 3000r/min, centrifugation time 5min, in collection Clear liquid obtains tip edge bladder-wrack extract after filtering.

It is further preferred that described is filtered into three layers of filtered through gauze.

It is further preferred that being filtered after three layers of filtered through gauze using the membrane filter in 0.2 μm of aperture.

Preferably, the grinding and sieving was 40 meshes.

The beneficial effects of the present invention are：

1) gadol extract is added in cosmetics as plant additive, has effects that excellent anti-wrinkle is crease-resistant.

2) collagen and polypeptide can provide energy for skin, adjust intracorporal moisture, promote the synthesis of protein, enzyme With regulation, facilitate metabolism, promote cell Proliferation, differentiation, can repair cell, it is crease-resistant, anti-oxidant and delay senescence.

3) the effect of Radix Glycyrrhizae has clearing heat and detoxicating, antibacterial anti-inflammatory, is suitble to various skin, is particularly suitable for sensibility skin, ocean Camomile have disinfecting, antimicrobial, releive sensitive skin the effect of.

4) present invention uses nanometer supercritical bee-glue, it is easy to which infiltration and absorption successfully solve and other ingredients Compatibility issues, nanometer supercritical bee-glue have the function of that strength is anti-oxidant, inhibit tyrosinase activity, and whitening spot-removing effect is aobvious It writes.

5) natural nutrient needed for tip edge bladder-wrack can provide skin rapid regeneration and cell normal growth, extra-nutrition It is lost, promotes skin metabolism, increase skin energy element ATP synthesis；It protects skin cell mitochondria and maintains mitochondria function Energy；Promote skin revitalization, skin is helped to reply health and vigor.

Specific embodiment

With reference to embodiments, the technical solution in the present invention is clearly and completely described.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.

A kind of anti-wrinkle Essence containing gadol extract, the raw material including following parts by weight：2-4 parts of root of kirilow rhodiola mention Take object, 2-4 parts of small molecule collagen polypeptide extracting solutions, 2-4 parts of propolis extracts, 0.5-1 parts of protease, 0.5-1 parts of aminopeptidases, 1-2 parts of camomile extracts, 1-2 parts of licorices, 1-3 parts of yeast polypeptides, 2-4 parts of tip edge bladder-wrack extracts, 1-3 parts of widows Peptide -20,0.5-1 part carbomer, 0.6-2 parts of aminomethyl propanols, 3-6 parts of propylene glycol, 3-6 parts of 1,3 butylene glycols, 0.5-1 parts of PEG- 40 rilanit specials, 0.5-1 part blumea oil, 0.5-1 parts of glycerol caprylates, 0.1-0.2 parts of methyl hydroxybenzoates, 0.1-0.2 parts of urine Bursin, 0.02-0.1 part EDETATE SODIUM, 0.03-0.1 parts of Sodium Hyaluronates, 70-100 parts of deionized waters.

The propolis extract is nanometer supercritical bee-glue.The nanometer supercritical bee-glue is wrapped by Phospholipids nanometer The nanometer supercritical bee-glue that the technology of wrapping up in is process.

The licorice is prepared using following methods：5g licorice medicinal materials are crushed, sieving, obtain powder, is added Concentration is the NaOH aqueous solution of 0.2mol/L, is 1 by solid-to-liquid ratio:The mixing of 10 ratios, 2h is extracted in hot dipping at 80 DEG C, is repeated 2 times, It filters, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifugated, goes under the revolving speed of 4000r/min Supernatant obtains sediment, as licorice.

The grinding and sieving was 40 meshes.

The camomile extract is prepared using following methods：5g chamomile is crushed, sieving, obtain powder, is added Concentration is the NaOH aqueous solution of 0.2mol/L, is 1 by solid-to-liquid ratio:The mixing of 10 ratios, 2h is extracted in hot dipping at 80 DEG C, is repeated 2 times, It filters, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifugated, goes under the revolving speed of 4000r/min Supernatant obtains sediment, as camomile extract.

The grinding and sieving was 40 meshes.

The tip edge bladder-wrack extract is prepared using following methods：Tip edge bladder-wrack is washed, is placed on logical It air-dries dry place and carries out air-dried, the tip edge bladder-wrack after air-drying is placed in micro-wave oven, the dry 4min of moderate heat, by the tip edge after drying Bladder-wrack is put into pulverizer and crushes, and smashed tip edge bladder-wrack is crossed 60 meshes, obtains tip edge bladder-wrack powder, weighs tip edge ink Angle algae powder 10g, deionized water 100g, are added to the container, and decoct at 90 DEG C and extract 100min, the substance in container is all taken Out, it is cooled to room temperature, is filtered with cryogenic freezing centrifuge, revolving speed 3000r/min, centrifugation time 5min, supernatant, mistake are collected After filter tip edge bladder-wrack extract, it is described to be filtered into three layers of filtered through gauze, using 0.2 after three layers of filtered through gauze The membrane filter filtering in μm aperture.

The present invention is exemplarily described above, it is clear that present invention specific implementation is not subject to the restrictions described above, As long as using the improvement for the various unsubstantialities that the inventive concept and technical scheme of the present invention carry out, or not improved this is sent out Bright conception and technical scheme directly apply to other occasions, within the scope of the present invention.Protection of the invention Range should be determined by the scope of protection defined in the claims.

Claims

1. a kind of preparation method of the anti-wrinkle Essence containing gadol extract, which is characterized in that include the following steps：

Step 1：Root of kirilow rhodiola is cleaned, is placed at shady and cool ventilation 2-4 days, then be placed in crock, 2-4 times of root of kirilow rhodiola weight is added Rice vinegar, sealing is 3-6 hours stewing, and filtering, filter residue is placed on the iron plate heated, dries 10-20 minutes, cools to room temperature, is ground into thin 120-140 mesh is crossed at end, and gains are added to 3-6 times of raw material weight of deionized water, and heating mixing while stirring, temperature It is sufficiently stirred and is uniformly dissolved at 50-70 DEG C, rose hip oil is added when cooling the temperature to 30-40 DEG C, after mixing evenly in 140-150 It sterilizes 20-40 seconds at DEG C, is cooled to 20 DEG C, obtains gadol extract；

Step 2：It is first impregnated fish-skin bone 30 seconds with the ethyl alcohol of mass concentration 60-80%, then is carefully cleaned with clear water, removal fat Class impurity cuts disrupting tissue with knife later, and water elutes 3 times, then presses fish-skin bone and water quality than 1:5 ratio impregnates fish-skin bone, PH value is adjusted to 6.9-8.5,100 degree is heated to, keeps the temperature 1 hour, be cooled to water temperature 40-50 degree, use 150-300 later Mesh filters 2-3 times, obtains macromolecular collagen protein extracting solution, and wherein collagen content is 0.05-1g/ml；

Step 3：Macromolecular collagen protein extracting solution is digested with biological enzyme, biological enzyme used is pepsin, dense Degree is 0.0001-500mg/ml, digest within 24 hours, puts into 90 DEG C of water-baths and is cooled to room temperature after destroying enzyme activity, at centrifugation Reason, 4500-10000rpm are centrifugated 30-10min, finally take supernatant, obtain small molecule collagen polypeptide extracting solution, wherein glue Former content of peptides is 0.05-1g/ml；

Step 4：Weigh in deionized water to water phase pot, sequentially add the measured EDETATE SODIUM of accurate scale, Sodium Hyaluronate, Carbomer, and heating mixes while stirring, is sufficiently stirred and is uniformly dissolved under temperature 60 C, sequentially adds propylene glycol, 1,3- fourth Glycol, methyl hydroxybenzoate, allantoin, temperature 60 C keep the temperature 30 minutes；

Step 5：Will in water phase pot material be pumped into vacuum emulsifying pot in, sequentially added under stirring gadol extract, Small molecule collagen polypeptide extracting solution, propolis extract, protease, aminopeptidase, camomile extract, licorice, yeast Polypeptide, tip edge bladder-wrack extract, oligopeptides -20 stir 30 minutes, are sufficiently mixed uniformly；

Step 6：It cools, when temperature drops to 45 DEG C, Cremophor RH40, blumea oil, sad glycerol is added Ester, and stir；

Step 7：Continue to cool down, when temperature drops to 35 DEG C, aminomethyl propanol is added, and stir, is cooled to Room temperature is to get Essence.

2. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 1, feature exist In：The propolis extract is nanometer supercritical bee-glue.

3. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 2, feature exist In：The nanometer supercritical bee-glue is the nanometer supercritical bee-glue being process by Phospholipids nano-encapsulated technology.

4. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 1, feature exist In the licorice is prepared using following methods：5g licorice medicinal materials are crushed, sieving, obtain powder, concentration, which is added, is The NaOH aqueous solution of 0.2mol/L is 1 by solid-to-liquid ratio:The mixing of 10 ratios, 2h is extracted in hot dipping at 80 DEG C, is repeated 2 times, and is filtered, It is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifugated under the revolving speed of 4000r/min, removes supernatant Obtain sediment, as licorice.

5. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 1, feature exist In the camomile extract is prepared using following methods：5g chamomile is crushed, sieving, obtain powder, concentration, which is added, is The NaOH aqueous solution of 0.2mol/L is 1 by solid-to-liquid ratio:The mixing of 10 ratios, 2h is extracted in hot dipping at 80 DEG C, is repeated 2 times, and is filtered, It is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifugated under the revolving speed of 4000r/min, removes supernatant Obtain sediment, as camomile extract.

6. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 1, feature exist In the tip edge bladder-wrack extract is prepared using following methods：Tip edge bladder-wrack is washed, aeration-drying is placed on Place carries out air-dried, and the tip edge bladder-wrack after air-drying is placed in micro-wave oven, the dry 4min of moderate heat, by the tip edge bladder-wrack after drying It is put into pulverizer and crushes, smashed tip edge bladder-wrack is crossed into 60 meshes, obtains tip edge bladder-wrack powder, weighs tip edge bladder-wrack powder 10g, deionized water 100g, are added to the container, and decoct at 90 DEG C and extract 100min, the substance in container are all taken out, drop It warms to room temperature, is filtered with cryogenic freezing centrifuge, revolving speed 3000r/min, centrifugation time 5min, supernatant is collected, after filtering Obtain tip edge bladder-wrack extract.

7. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 6, feature exist In：Described is filtered into three layers of filtered through gauze.

8. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 7, feature exist In：It is filtered after three layers of filtered through gauze using the membrane filter in 0.2 μm of aperture.

9. a kind of preparation method of anti-wrinkle Essence containing gadol extract according to claim 4 or 5, feature It is：The grinding and sieving was 40 meshes.