CN108578303A - A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract - Google Patents
A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract Download PDFInfo
- Publication number
- CN108578303A CN108578303A CN201810831875.4A CN201810831875A CN108578303A CN 108578303 A CN108578303 A CN 108578303A CN 201810831875 A CN201810831875 A CN 201810831875A CN 108578303 A CN108578303 A CN 108578303A
- Authority
- CN
- China
- Prior art keywords
- extract
- flos nelumbinis
- water
- preparation
- wrack
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000284 extract Substances 0.000 title claims abstract description 48
- 241000628997 Flos Species 0.000 title claims abstract description 24
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 102000008186 Collagen Human genes 0.000 claims abstract description 21
- 108010035532 Collagen Proteins 0.000 claims abstract description 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 16
- 229920001436 collagen Polymers 0.000 claims abstract description 15
- 229920001184 polypeptide Polymers 0.000 claims abstract description 15
- 102000004190 Enzymes Human genes 0.000 claims abstract description 13
- 108090000790 Enzymes Proteins 0.000 claims abstract description 13
- 230000000694 effects Effects 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 150000003384 small molecules Chemical class 0.000 claims abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- 238000000605 extraction Methods 0.000 claims description 20
- 241000227647 Fucus vesiculosus Species 0.000 claims description 19
- 240000002853 Nelumbo nucifera Species 0.000 claims description 18
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims description 18
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 241000202807 Glycyrrhiza Species 0.000 claims description 13
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 13
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 13
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 239000003292 glue Substances 0.000 claims description 12
- 229940010454 licorice Drugs 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 11
- 238000007873 sieving Methods 0.000 claims description 10
- 210000000988 bone and bone Anatomy 0.000 claims description 9
- 229940118127 fucus vesiculosus extract Drugs 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 239000002002 slurry Substances 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 241000241413 Propolis Species 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 229940069949 propolis Drugs 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000007598 dipping method Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000013049 sediment Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 102000004400 Aminopeptidases Human genes 0.000 claims description 4
- 108090000915 Aminopeptidases Proteins 0.000 claims description 4
- 241001252601 Blumea Species 0.000 claims description 4
- 108091005804 Peptidases Proteins 0.000 claims description 4
- 239000004365 Protease Substances 0.000 claims description 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 3
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 3
- 244000042664 Matricaria chamomilla Species 0.000 claims description 3
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 3
- 108010038807 Oligopeptides Proteins 0.000 claims description 3
- 102000015636 Oligopeptides Human genes 0.000 claims description 3
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 3
- 238000007605 air drying Methods 0.000 claims description 3
- 229960000458 allantoin Drugs 0.000 claims description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 3
- 238000010612 desalination reaction Methods 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- 150000003904 phospholipids Chemical class 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229940088598 enzyme Drugs 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 102000057297 Pepsin A Human genes 0.000 claims 1
- 108090000284 Pepsin A Proteins 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229940111202 pepsin Drugs 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 abstract description 3
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 235000006708 antioxidants Nutrition 0.000 abstract description 3
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 230000004663 cell proliferation Effects 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 230000004069 differentiation Effects 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 230000008439 repair process Effects 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 238000004945 emulsification Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 10
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 2
- 210000002318 cardia Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- KODLUXHSIZOKTG-UHFFFAOYSA-N 1-aminobutan-2-ol Chemical class CCC(O)CN KODLUXHSIZOKTG-UHFFFAOYSA-N 0.000 description 1
- DIBAKBGYJUCGDL-UHFFFAOYSA-N 2,6-diamino-n-[1-[(2-amino-2-oxoethyl)amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCCC(N)C(=O)NC(C(=O)NCC(N)=O)CC1=CN=CN1 DIBAKBGYJUCGDL-UHFFFAOYSA-N 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 108010026970 bursopoietin Proteins 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical class COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical class CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract, belongs to Essence preparing technical field, including：It prepares Flos Nelumbinis extract, prepare small molecule collagen polypeptide extracting solution, the preparation of water phase liquid, emulsification, cool down and etc..The present invention is added to as plant additive in cosmetics using Flos Nelumbinis extract, has effects that excellent anti-wrinkle is crease-resistant.Collagen and polypeptide can provide energy for skin, adjust internal moisture, promote the synthesis and regulation and control of protein, enzyme, contribute to metabolism, promote cell Proliferation, differentiation, can repair cell, crease-resistant, anti-oxidant and anti-aging.
Description
Technical field
The present invention relates to Essence preparing technical field, more particularly to a kind of anti-wrinkle Essence containing Flos Nelumbinis extract
Preparation method.
Background technology
Essence is the superfine product in skin care item, and ingredient is exquisite, effect is powerful, significant effect, remains what it possessed
It is noble and mysterious, it is suitable for any skin or inclined oily skin, preferably puts in the vial, take at any time.Essence is used for toner
Later, before face cream.Commonly there is the problems such as poor permeability, be not easy to absorb, and single effect in current Essence, functional
It is not strong.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of anti-wrinkle Essence containing Flos Nelumbinis extract
Preparation method, there is good penetrability, easily absorb, the effect of anti-wrinkle.
The present invention uses following technical scheme：
A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract, includes the following steps：
Step 1：It is crushed after lotus flower and water are mixed, the mass ratio of the lotus flower and water is 3:1, the crushing
Temperature be no more than 50 DEG C, lotus flower slurry is obtained after the material after crushing is rolled, the lotus flower slurry is being extracted
It takes in agent and is extracted, obtain extract liquor, the extractant includes glycerine, propylene glycol and water, the lotus flower slurry and extraction
The mass ratio of agent is 3:1, the mass ratio of the glycerine, propylene glycol and water is 1:1:70, the temperature of the extraction be 25 DEG C hereinafter,
The time of the extraction is 60min-600min, by the extract liquor successively after filtering, desalination, decoloration and sterilization treatment,
Obtain Flos Nelumbinis extract；
Step 2：It first uses the ethyl alcohol of mass concentration 60-80% to impregnate fish-skin bone 30 seconds, then is carefully cleaned with clear water, removed
Fats impurity cuts disrupting tissue, water wash 3 times with knife later, then presses fish-skin bone with water quality than 1:5 ratio impregnates fish-skin
Bone adjusts pH value to 6.9-8.5, is heated to 100 degree, keeps the temperature 1 hour, be cooled to water temperature 40-50 degree, use 150- later
300 mesh filter 2-3 times, obtain macromolecular collagen protein extracting solution, and wherein collagen content is 0.05-1g/ml；
Step 3：Macromolecular collagen protein extracting solution is digested with biological enzyme, biological enzyme used is stomach cardia
Enzyme, a concentration of 0.0001-500mg/ml digest within 24 hours, are put into 90 DEG C of water-baths and be cooled to room temperature after destroying enzyme activity, from
Heart processing, 4500-10000rpm centrifuge 30-10min, finally take supernatant, obtain small molecule collagen polypeptide extracting solution,
Middle collagen polypeptide content is 0.05-1g/ml；
Step 4：It weighs in deionized water to water phase pot, sequentially adds the measured EDETATE SODIUM of accurate scale, hyaluronic acid
Sodium, carbomer, and heating mixes while stirring, is sufficiently stirred and is uniformly dissolved under temperature 60 C, sequentially adds propylene glycol, 1,3-
Butanediol, methyl hydroxybenzoate, allantoin, temperature 60 C keep the temperature 30 minutes；
Step 5：Material in water phase pot is pumped into vacuum emulsifying pot, lotus flower extraction is sequentially added under stirring
Object, small molecule collagen polypeptide extracting solution, propolis extract, protease, aminopeptidase, camomile extract, licorice, ferment
Female polypeptide, tip edge bladder-wrack extract, oligopeptides -20 stir 30 minutes, are sufficiently mixed uniformly；
Step 6：It cools, when temperature drops to 45 DEG C, Cremophor RH40, blumea oil, octanoic acid is added
Glyceride, and stir；
Step 7：Continue to cool down, when temperature drops to 35 DEG C, aminomethyl propanol is added, and stir, then cold
But to room temperature to get Essence.
Preferably, the propolis extract is nanometer supercritical bee-glue.
It is further preferred that the nanometer supercritical bee-glue is the nanometer being process by Phospholipids nano-encapsulated technology
Supercritical bee-glue.
Preferably, the licorice is prepared using following methods：5g licorice medicinal materials are crushed, sieving, obtains powder
The NaOH aqueous solutions of a concentration of 0.2mol/L are added in body, are 1 by solid-to-liquid ratio:10 ratios mix, the hot dipping extraction 2h at 80 DEG C,
It is repeated 2 times, filters, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifuged under the rotating speed of 4000r/min
Separation, goes supernatant to obtain sediment, as licorice.
Preferably, the camomile extract is prepared using following methods：5g chamomiles are crushed, sieving, obtains powder
The NaOH aqueous solutions of a concentration of 0.2mol/L are added in body, are 1 by solid-to-liquid ratio:10 ratios mix, the hot dipping extraction 2h at 80 DEG C,
It is repeated 2 times, filters, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, is centrifuged under the rotating speed of 4000r/min
Separation, goes supernatant to obtain sediment, as camomile extract.
Preferably, the tip edge bladder-wrack extract is prepared using following methods：Tip edge bladder-wrack is washed, is put
It sets and is air-dried at aeration-drying, the tip edge bladder-wrack after air-drying is placed in micro-wave oven, moderate heat dries 4min, after drying
Tip edge bladder-wrack be put into pulverizer and crush, the tip edge bladder-wrack after crushing is crossed into 60 mesh sieve, tip edge bladder-wrack powder is obtained, weighs
Tip edge bladder-wrack powder 10g, deionized water 100g, are added to the container, and extraction 100min are decocted at 90 DEG C, by the substance in container
It all takes out, is cooled to room temperature, filtered with cryogenic freezing centrifuge, rotating speed 3000r/min, centrifugation time 5min, in collection
Clear liquid obtains tip edge bladder-wrack extract after filtering.
It is further preferred that described is filtered into three layers of filtered through gauze.
It is further preferred that being filtered using the membrane filter in 0.2 μm of aperture after three layers of filtered through gauze.
Preferably, the grinding and sieving was 40 mesh sieve.
The beneficial effects of the present invention are：
1) Flos Nelumbinis extract is added to as plant additive in cosmetics, has effects that excellent anti-wrinkle is crease-resistant.
2) collagen can provide energy with polypeptide for skin, adjust internal moisture, promote the synthesis of protein, enzyme
With regulation and control, contribute to metabolism, promote cell Proliferation, differentiation, can repair cell, it is crease-resistant, anti-oxidant and slow down aging.
3) the effect of Radix Glycyrrhizae has clearing heat and detoxicating, antibacterial anti-inflammatory is suitble to various skin, is particularly suitable for sensibility skin, ocean
Camomile have disinfecting, antimicrobial, releive sensitive skin the effect of.
4) present invention uses nanometer supercritical bee-glue, it is easy to which infiltration and absorption successfully solve and other ingredients
Compatibility issues, nanometer supercritical bee-glue have the function of that strength is anti-oxidant, inhibit tyrosinase activity, and whitening spot-removing effect is aobvious
It writes.
5) tip edge bladder-wrack can provide the natural nutrient needed for skin rapid regeneration and cell normal growth, extra-nutrition
It is lost in, promotes skin metabolism, increase the ATP synthesis of skin energy element；It protects skin cell mitochondria and maintains mitochondria work(
Energy；Promote skin revitalization, skin is helped to reply health and vigor.
Specific implementation mode
With reference to embodiments, the technical solution in the present invention is clearly and completely described.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
A kind of anti-wrinkle Essence containing Flos Nelumbinis extract, includes the raw material of following parts by weight：2-4 parts of lotus flower extractions
Object, 2-4 parts of small molecule collagen polypeptide extracting solutions, 2-4 parts of propolis extracts, 0.5-1 parts of protease, 0.5-1 parts of aminopeptidases, 1-
2 parts of camomile extracts, 1-2 parts of licorices, 1-3 parts of yeast polypeptides, 2-4 parts of tip edge bladder-wrack extracts, 1-3 parts of widows
Peptide -20,0.5-1 part carbomer, 0.6-2 parts of aminomethyl propanols, 3-6 parts of propylene glycol, 3-6 parts of 1,3 butylene glycols, 0.5-1 parts of PEG-
40 rilanit specials, 0.5-1 part blumea oil, 0.5-1 parts of glycerol caprylates, 0.1-0.2 parts of methyl hydroxybenzoates, 0.1-0.2 parts of urine
Bursin, 0.02-0.1 part EDETATE SODIUM, 0.03-0.1 parts of Sodium Hyaluronates, 70-100 parts of deionized waters.
A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract, includes the following steps：
Step 1：It is crushed after lotus flower and water are mixed, the mass ratio of the lotus flower and water is 3:1, the crushing
Temperature be no more than 50 DEG C, lotus flower slurry is obtained after the material after crushing is rolled, the lotus flower slurry is being extracted
It takes in agent and is extracted, obtain extract liquor, the extractant includes glycerine, propylene glycol and water, the lotus flower slurry and extraction
The mass ratio of agent is 3:1, the mass ratio of the glycerine, propylene glycol and water is 1:1:70, the temperature of the extraction be 25 DEG C hereinafter,
The time of the extraction is 60min-600min, by the extract liquor successively after filtering, desalination, decoloration and sterilization treatment,
Obtain Flos Nelumbinis extract；
Step 2：It first uses the ethyl alcohol of mass concentration 60-80% to impregnate fish-skin bone 30 seconds, then is carefully cleaned with clear water, removed
Fats impurity cuts disrupting tissue, water wash 3 times with knife later, then presses fish-skin bone with water quality than 1:5 ratio impregnates fish-skin
Bone adjusts pH value to 6.9-8.5, is heated to 100 degree, keeps the temperature 1 hour, be cooled to water temperature 40-50 degree, use 150- later
300 mesh filter 2-3 times, obtain macromolecular collagen protein extracting solution, and wherein collagen content is 0.05-1g/ml；
Step 3：Macromolecular collagen protein extracting solution is digested with biological enzyme, biological enzyme used is stomach cardia
Enzyme, a concentration of 0.0001-500mg/ml digest within 24 hours, are put into 90 DEG C of water-baths and be cooled to room temperature after destroying enzyme activity, from
Heart processing, 4500-10000rpm centrifuge 30-10min, finally take supernatant, obtain small molecule collagen polypeptide extracting solution,
Middle collagen polypeptide content is 0.05-1g/ml；
Step 4：It weighs in deionized water to water phase pot, sequentially adds the measured EDETATE SODIUM of accurate scale, hyaluronic acid
Sodium, carbomer, and heating mixes while stirring, is sufficiently stirred and is uniformly dissolved under temperature 60 C, sequentially adds propylene glycol, 1,3-
Butanediol, methyl hydroxybenzoate, allantoin, temperature 60 C keep the temperature 30 minutes；
Step 5：Material in water phase pot is pumped into vacuum emulsifying pot, lotus flower extraction is sequentially added under stirring
Object, small molecule collagen polypeptide extracting solution, propolis extract, protease, aminopeptidase, camomile extract, licorice, ferment
Female polypeptide, tip edge bladder-wrack extract, oligopeptides -20 stir 30 minutes, are sufficiently mixed uniformly；
Step 6：It cools, when temperature drops to 45 DEG C, Cremophor RH40, blumea oil, octanoic acid is added
Glyceride, and stir；
Step 7：Continue to cool down, when temperature drops to 35 DEG C, aminomethyl propanol is added, and stir, then cold
But to room temperature to get Essence.
The propolis extract is nanometer supercritical bee-glue.The nanometer supercritical bee-glue is wrapped by Phospholipids nanometer
The nanometer supercritical bee-glue that the technology of wrapping up in is process.
The licorice is prepared using following methods：5g licorice medicinal materials are crushed, sieving, obtain powder, is added
The NaOH aqueous solutions of a concentration of 0.2mol/L are 1 by solid-to-liquid ratio:10 ratios mix, and hot dipping extraction 2h, is repeated 2 times at 80 DEG C,
Filtering, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, centrifuges, goes under the rotating speed of 4000r/min
Supernatant obtains sediment, as licorice.
The grinding and sieving was 40 mesh sieve.
The camomile extract is prepared using following methods：5g chamomiles are crushed, sieving, obtain powder, is added
The NaOH aqueous solutions of a concentration of 0.2mol/L are 1 by solid-to-liquid ratio:10 ratios mix, and hot dipping extraction 2h, is repeated 2 times at 80 DEG C,
Filtering, it is 3% hydrochloric acid tune pH value to 1-2.5 that mass concentration is added in filtrate, centrifuges, goes under the rotating speed of 4000r/min
Supernatant obtains sediment, as camomile extract.
The grinding and sieving was 40 mesh sieve.
The tip edge bladder-wrack extract is prepared using following methods：Tip edge bladder-wrack is washed, is placed on logical
It air-dries dry place to be air-dried, the tip edge bladder-wrack after air-drying is placed in micro-wave oven, moderate heat dries 4min, by the tip edge after drying
Bladder-wrack is put into pulverizer and crushes, and the tip edge bladder-wrack after crushing is crossed 60 mesh sieve, obtains tip edge bladder-wrack powder, weighs tip edge ink
Angle algae powder 10g, deionized water 100g, are added to the container, and extraction 100min is decocted at 90 DEG C, the substance in container is all taken
Go out, be cooled to room temperature, filtered with cryogenic freezing centrifuge, rotating speed 3000r/min, centrifugation time 5min, collects supernatant, mistake
After filter tip edge bladder-wrack extract, it is described to be filtered into three layers of filtered through gauze, using 0.2 after described three layers of filtered through gauze
The membrane filter filtering in μm aperture.
The present invention is exemplarily described above, it is clear that present invention specific implementation is not subject to the restrictions described above,
As long as using the improvement of the various unsubstantialities of inventive concept and technical scheme of the present invention progress, or not improved this is sent out
Bright design and technical solution directly applies to other occasions, within protection scope of the present invention.The protection of the present invention
Range should be determined by the scope of protection defined in the claims.
Claims (9)
1. a kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract, which is characterized in that include the following steps：
Step 1：It is crushed after lotus flower and water are mixed, the mass ratio of the lotus flower and water is 3:1, the temperature of the crushing
Degree is no more than 50 DEG C, lotus flower slurry is obtained after the material after crushing is rolled, by the lotus flower slurry in extractant
In extracted, obtain extract liquor, the extractant includes glycerine, propylene glycol and water, the lotus flower slurry and extractant
Mass ratio is 3:1, the mass ratio of the glycerine, propylene glycol and water is 1:1:70, the temperature of the extraction is 25 DEG C hereinafter, described
The time of extraction is 60min-600min, and the extract liquor is obtained after filtering, desalination, decoloration and sterilization treatment successively
Flos Nelumbinis extract；
Step 2：It first uses the ethyl alcohol of mass concentration 60-80% to impregnate fish-skin bone 30 seconds, then is carefully cleaned with clear water, removal fat
Class impurity cuts disrupting tissue, water wash 3 times with knife later, then presses fish-skin bone with water quality than 1:5 ratio impregnates fish-skin bone,
PH value is adjusted to 6.9-8.5,100 degree is heated to, keeps the temperature 1 hour, be cooled to water temperature 40-50 degree, use 150-300 later
Mesh filters 2-3 times, obtains macromolecular collagen protein extracting solution, and wherein collagen content is 0.05-1g/ml；
Step 3：Macromolecular collagen protein extracting solution is digested with biological enzyme, biological enzyme used is pepsin, dense
Degree is 0.0001-500mg/ml, digest within 24 hours, puts into 90 DEG C of water-baths and is cooled to room temperature after destroying enzyme activity, at centrifugation
Reason, 4500-10000rpm centrifuge 30-10min, finally take supernatant, obtain small molecule collagen polypeptide extracting solution, wherein glue
Former content of peptides is 0.05-1g/ml；
Step 4：Weigh in deionized water to water phase pot, sequentially add the measured EDETATE SODIUM of accurate scale, Sodium Hyaluronate,
Carbomer, and heating mixes while stirring, is sufficiently stirred and is uniformly dissolved under temperature 60 C, sequentially adds propylene glycol, 1,3- fourths
Glycol, methyl hydroxybenzoate, allantoin, temperature 60 C keep the temperature 30 minutes；
Step 5：It material will be pumped into vacuum emulsifying pot in water phase pot, Flos Nelumbinis extract, small is sequentially added under stirring
Molecule collagen polypeptide extracting solution, propolis extract, protease, aminopeptidase, camomile extract, licorice, yeast are more
Peptide, tip edge bladder-wrack extract, oligopeptides -20 stir 30 minutes, are sufficiently mixed uniformly；
Step 6：It cools, when temperature drops to 45 DEG C, Cremophor RH40, blumea oil, sad glycerine is added
Ester, and stir；
Step 7：Continue to cool down, when temperature drops to 35 DEG C, aminomethyl propanol is added, and stir, is cooled to
Room temperature is to get Essence.
2. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 1, it is characterised in that：
The propolis extract is nanometer supercritical bee-glue.
3. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 2, it is characterised in that：
The nanometer supercritical bee-glue is the nanometer supercritical bee-glue being process by Phospholipids nano-encapsulated technology.
4. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 1, which is characterized in that
The licorice is prepared using following methods：5g licorice medicinal materials are crushed, sieving, obtain powder, is added a concentration of
The NaOH aqueous solutions of 0.2mol/L are 1 by solid-to-liquid ratio:10 ratios mix, and hot dipping extraction 2h, is repeated 2 times at 80 DEG C, filters,
In filtrate be added mass concentration be 3% hydrochloric acid tune pH value to 1-2.5, centrifuged under the rotating speed of 4000r/min, remove supernatant
Obtain sediment, as licorice.
5. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 1, which is characterized in that
The camomile extract is prepared using following methods：5g chamomiles are crushed, sieving, obtain powder, is added a concentration of
The NaOH aqueous solutions of 0.2mol/L are 1 by solid-to-liquid ratio:10 ratios mix, and hot dipping extraction 2h, is repeated 2 times at 80 DEG C, filters,
In filtrate be added mass concentration be 3% hydrochloric acid tune pH value to 1-2.5, centrifuged under the rotating speed of 4000r/min, remove supernatant
Obtain sediment, as camomile extract.
6. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 1, which is characterized in that
The tip edge bladder-wrack extract is prepared using following methods：Tip edge bladder-wrack is washed, is placed at aeration-drying
It is air-dried, the tip edge bladder-wrack after air-drying is placed in micro-wave oven, moderate heat dries 4min, and the tip edge bladder-wrack after drying is put
Enter in pulverizer and crush, the tip edge bladder-wrack after crushing is crossed into 60 mesh sieve, tip edge bladder-wrack powder is obtained, weighs tip edge bladder-wrack powder
10g, deionized water 100g, are added to the container, and extraction 100min is decocted at 90 DEG C, the substance in container are all taken out, drop
It warms to room temperature, is filtered with cryogenic freezing centrifuge, rotating speed 3000r/min, centrifugation time 5min, supernatant is collected, after filtering
Obtain tip edge bladder-wrack extract.
7. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 6, it is characterised in that：
Described is filtered into three layers of filtered through gauze.
8. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 7, it is characterised in that：
It is filtered using the membrane filter in 0.2 μm of aperture after three layers of filtered through gauze.
9. a kind of preparation method of anti-wrinkle Essence containing Flos Nelumbinis extract according to claim 4 or 5, feature exist
In：The grinding and sieving was 40 mesh sieve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810831875.4A CN108578303A (en) | 2018-07-26 | 2018-07-26 | A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810831875.4A CN108578303A (en) | 2018-07-26 | 2018-07-26 | A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108578303A true CN108578303A (en) | 2018-09-28 |
Family
ID=63618896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810831875.4A Withdrawn CN108578303A (en) | 2018-07-26 | 2018-07-26 | A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108578303A (en) |
-
2018
- 2018-07-26 CN CN201810831875.4A patent/CN108578303A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108852989A (en) | A kind of preparation method of the anti-wrinkle Essence containing pomegranate rind extract | |
| CN108836909A (en) | A kind of preparation method of the anti-wrinkle Essence containing gadol extract | |
| CN102940244B (en) | Sea cucumber oral liquid and preparation process thereof | |
| CN111821233B (en) | Plant whitening natural active compound composition and preparation method and application thereof | |
| CN107647414A (en) | A kind of instant bird's nest collagen Gly-His-Lys | |
| CN104284601B (en) | Secrete for promoting insulin-like growth factor and the white radix-polygoni multiflori extract of bone growth and Radix Dipsaci extract and manufacture method thereof | |
| CN108578344A (en) | A kind of preparation method of the Post-basking repairing mask containing Folum Ilicis extract | |
| CN108815093A (en) | A kind of pore shrinks Essence and preparation method thereof | |
| CN108836933A (en) | A kind of preparation method of the anti-wrinkle Essence containing peony extract | |
| CN108578345A (en) | A kind of preparation method of the anti-wrinkle Essence containing Ginger P.E | |
| CN111419760A (en) | Fresh black tiger leaf extracting solution and preparation method and application thereof | |
| CN102578452B (en) | Skin-nourishing nutritional food | |
| CN108542876A (en) | A kind of preparation method of the anti-wrinkle Essence containing Mao Xu Cao extract | |
| CN108815092A (en) | A kind of preparation method of the anti-acne maintenance Essence containing tea polyphenols | |
| CN108685838A (en) | A kind of preparation method of the anti-wrinkle Essence containing safflower extract | |
| CN108309873A (en) | Revitalizing Balancing Toning Essence | |
| CN108578303A (en) | A kind of preparation method of the anti-wrinkle Essence containing Flos Nelumbinis extract | |
| CN108743432A (en) | A kind of preparation method of the anti-wrinkle Essence containing ooze extract | |
| CN108553379A (en) | A kind of anti-wrinkle Essence containing Chinese herbal medicine extract | |
| CN102366003A (en) | Instant collagen tea and manufacturing method thereof | |
| CN108542875A (en) | A kind of anti-wrinkle Essence containing logwood extract | |
| CN108403558A (en) | A kind of dendrobium candidum mask product | |
| CN108210440A (en) | A kind of toner based on pilose antler extracting solution and preparation method thereof | |
| CN109395153A (en) | A kind of wound repair materials | |
| CN108219021A (en) | Method that is a kind of while extracting polysaccharide, polyphenol and polypeptide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180928 |