CN108721677B - 复合性材料 - Google Patents
复合性材料 Download PDFInfo
- Publication number
- CN108721677B CN108721677B CN201710248691.0A CN201710248691A CN108721677B CN 108721677 B CN108721677 B CN 108721677B CN 201710248691 A CN201710248691 A CN 201710248691A CN 108721677 B CN108721677 B CN 108721677B
- Authority
- CN
- China
- Prior art keywords
- hydrophilic
- composite material
- hydrophilic polymer
- compound
- wound healing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 57
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 81
- 230000029663 wound healing Effects 0.000 claims abstract description 59
- 150000001875 compounds Chemical class 0.000 claims abstract description 48
- 230000001737 promoting effect Effects 0.000 claims abstract description 41
- 239000000178 monomer Substances 0.000 claims abstract description 35
- 239000000758 substrate Substances 0.000 claims abstract description 24
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 19
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 6
- 239000003505 polymerization initiator Substances 0.000 claims description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 9
- 229920001436 collagen Polymers 0.000 claims description 9
- 229910052914 metal silicate Inorganic materials 0.000 claims description 9
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 8
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 108090000695 Cytokines Proteins 0.000 claims description 8
- 102000004127 Cytokines Human genes 0.000 claims description 8
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims description 8
- 229920002674 hyaluronan Polymers 0.000 claims description 8
- 229960003160 hyaluronic acid Drugs 0.000 claims description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 7
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 claims description 6
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 125000000524 functional group Chemical group 0.000 claims description 6
- 239000003102 growth factor Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 5
- GDOBGDUGIFUCJV-UHFFFAOYSA-N 2,2-dimethylbutane;2-methylprop-2-enoic acid Chemical compound CCC(C)(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O.CC(=C)C(O)=O GDOBGDUGIFUCJV-UHFFFAOYSA-N 0.000 claims description 4
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 claims description 4
- LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 claims description 4
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 4
- UKMBKKFLJMFCSA-UHFFFAOYSA-N [3-hydroxy-2-(2-methylprop-2-enoyloxy)propyl] 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(CO)OC(=O)C(C)=C UKMBKKFLJMFCSA-UHFFFAOYSA-N 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- FFYWKOUKJFCBAM-UHFFFAOYSA-N ethenyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC=C FFYWKOUKJFCBAM-UHFFFAOYSA-N 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- DTPIAVTZZGLIFY-UHFFFAOYSA-N C(CN)N.CC(=CC(=O)N)C Chemical compound C(CN)N.CC(=CC(=O)N)C DTPIAVTZZGLIFY-UHFFFAOYSA-N 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 38
- -1 silica compound Chemical class 0.000 abstract description 24
- 239000000377 silicon dioxide Substances 0.000 abstract description 19
- 206010052428 Wound Diseases 0.000 description 36
- 208000027418 Wounds and injury Diseases 0.000 description 35
- 239000002245 particle Substances 0.000 description 18
- 229910052814 silicon oxide Inorganic materials 0.000 description 17
- 239000000017 hydrogel Substances 0.000 description 14
- 239000000853 adhesive Substances 0.000 description 13
- 230000001070 adhesive effect Effects 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 12
- 239000007787 solid Substances 0.000 description 11
- 229920001296 polysiloxane Polymers 0.000 description 10
- 235000012239 silicon dioxide Nutrition 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 229920002554 vinyl polymer Polymers 0.000 description 7
- 239000003999 initiator Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 238000006116 polymerization reaction Methods 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 5
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 4
- GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 description 4
- 239000003522 acrylic cement Substances 0.000 description 4
- 238000004026 adhesive bonding Methods 0.000 description 4
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 210000001339 epidermal cell Anatomy 0.000 description 4
- 239000000416 hydrocolloid Substances 0.000 description 4
- 229910010272 inorganic material Inorganic materials 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000000379 polymerizing effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 150000002484 inorganic compounds Chemical class 0.000 description 3
- 229910052909 inorganic silicate Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- LGJCFVYMIJLQJO-UHFFFAOYSA-N 1-dodecylperoxydodecane Chemical compound CCCCCCCCCCCCOOCCCCCCCCCCCC LGJCFVYMIJLQJO-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 239000004342 Benzoyl peroxide Substances 0.000 description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 description 2
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 description 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- 101000653787 Mus musculus Protein S100-A11 Proteins 0.000 description 2
- 108010025020 Nerve Growth Factor Proteins 0.000 description 2
- 102000015336 Nerve Growth Factor Human genes 0.000 description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 102000013275 Somatomedins Human genes 0.000 description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- OBNDGIHQAIXEAO-UHFFFAOYSA-N [O].[Si] Chemical group [O].[Si] OBNDGIHQAIXEAO-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000008062 acetophenones Chemical class 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 125000005594 diketone group Chemical group 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003344 environmental pollutant Substances 0.000 description 2
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical group NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229940126864 fibroblast growth factor Drugs 0.000 description 2
- ZSDPJPHNMOTSQZ-UHFFFAOYSA-N hydroxy propan-2-yl carbonate Chemical compound CC(C)OC(=O)OO ZSDPJPHNMOTSQZ-UHFFFAOYSA-N 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- RBQRWNWVPQDTJJ-UHFFFAOYSA-N methacryloyloxyethyl isocyanate Chemical compound CC(=C)C(=O)OCCN=C=O RBQRWNWVPQDTJJ-UHFFFAOYSA-N 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229940053128 nerve growth factor Drugs 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 231100000719 pollutant Toxicity 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 1
- VFOZPUQEFHZHBT-UHFFFAOYSA-N 2-ethenylbenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1C=C VFOZPUQEFHZHBT-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 description 1
- IQAGXMNEUYBTLG-UHFFFAOYSA-N 5-hydroxy-2-methylpent-2-enamide Chemical compound NC(=O)C(C)=CCCO IQAGXMNEUYBTLG-UHFFFAOYSA-N 0.000 description 1
- 102100025250 C-X-C motif chemokine 14 Human genes 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 102000003951 Erythropoietin Human genes 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 101000858068 Homo sapiens C-X-C motif chemokine 14 Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 229910020781 SixOy Inorganic materials 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- NBZANZVJRKXVBH-GYDPHNCVSA-N alpha-Cryptoxanthin Natural products O[C@H]1CC(C)(C)C(/C=C/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/[C@H]2C(C)=CCCC2(C)C)\C)/C)\C)/C)=C(C)C1 NBZANZVJRKXVBH-GYDPHNCVSA-N 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical class C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- FXPHJTKVWZVEGA-UHFFFAOYSA-N ethenyl hydrogen carbonate Chemical compound OC(=O)OC=C FXPHJTKVWZVEGA-UHFFFAOYSA-N 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 125000001905 inorganic group Chemical group 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 150000003951 lactams Chemical group 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical group CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- DCUFMVPCXCSVNP-UHFFFAOYSA-N methacrylic anhydride Chemical compound CC(=C)C(=O)OC(=O)C(C)=C DCUFMVPCXCSVNP-UHFFFAOYSA-N 0.000 description 1
- VHRYZQNGTZXDNX-UHFFFAOYSA-N methacryloyl chloride Chemical compound CC(=C)C(Cl)=O VHRYZQNGTZXDNX-UHFFFAOYSA-N 0.000 description 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 description 1
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000005372 silanol group Chemical group 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/48—Surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0033—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
- C08F220/585—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine and containing other heteroatoms, e.g. 2-acrylamido-2-methylpropane sulfonic acid [AMPS]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/36—Amides or imides
- C08F222/38—Amides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/24—Homopolymers or copolymers of amides or imides
- C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明是关于一种复合性材料，其包含一亲水性基材以及一促进伤口愈合的化合物，其中该亲水性基材为一亲水性聚合物的反应产物，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中该促进伤口愈合的化合物分布于该亲水性基材中。
Description
技术领域
本发明是关于一复合性材料，该复合性材料为一含有促进伤口愈合的化合物的高强度三维网络结构的固态亲水性聚合物。
背景技术
以往保持伤口干燥为主要护理原则，因此会使用干式的纱布敷料来保护伤口。但是，常发生伤口与纱布沾黏的情况，导致除去敷料时，沾黏到刚愈合的伤口而造成伤口二次伤害与疼痛。近年来，相关研究证明保持伤口湿润有助在表皮细胞的移动与增生，能加速伤口愈合，在是产生各种湿式敷料，如水胶体(Hydrocolloids)与水凝胶(Hydrogels)敷料。
然而，水胶体敷料系以羧甲基纤维素为主，易遭感染伤口之细菌分解并产生异味；因此，水胶体不可用在感染性伤口。
另一具有吸水膨润的水凝胶，现有产品的力学强度不足，例如，台湾专利公告号第M419555、I267387、I429462、I504420号专利；中国专利公告号第CN204863670号专利及美国专利公开号第2013/0072843号专利系揭示以水凝胶结合不织布或纤维做支持层强化其结构；但水凝胶吸收水性溶液膨润后结构仍旧易碎，导致除去敷料时，碎裂残胶不易清除。
一般为了加速慢性伤口的愈合，除了保持伤口湿润与阻隔外在伤害的敷料，亦需促进伤口愈合因子。例如，美国专利公告号第5,489,304及5,716,411号专利是将胶原蛋白-葡萄糖胺聚醣(glycosaminoglycan)混合后覆盖在伤口表面，再涂覆一层经培养的动物或人类的表皮细胞层，以促使皮肤再生。美国专利专利号第5,977,088号专利揭示一种含有治疗或促进缓解皮肤疾病的药剂及透明质酸的医药组合物，该医药组合物是利用透明质酸促进或引起药剂输送至伤员的皮肤内，其并可累积及延长药剂停留在该部位。
但上述加速伤口愈合的有效因子或湿式敷料，皆需先涂敷有效因子后，再覆盖敷料保护的二步骤，故照护流程烦琐；再者，促进伤口愈合因子若涂敷过量，不仅浪费又易使敷料固定不佳。虽有台湾专利公告号第I264306号专利揭露一胶原蛋白-透明质酸混合物涂布纱布敷料，却属不利伤口愈合的干式纱布的复合性材料。
因此，目前如何将有加速伤口愈合的有效因子与湿式敷料有效的结合，加强伤口护理和愈合，是目前业界解决的问题。
发明内容
有鉴于此，本发明提供一种具有适当力学强度的亲水性敷料，其包含一复合性材料以及一薄膜，最特别的是该复合性材料由一亲水性聚合物以及一促进伤口愈合的化合物所组成。该亲水性聚合物为具有高强度与亲水性有利的特性组合的聚合物；因此，该亲水性聚合物除了维持伤口湿润，加速表皮细胞的移动与增生外，因该亲水性聚合物为具有高强度三维网络结构的固态亲水聚合物，故克服以往水凝胶因吸收水性溶液而膨润后易碎的情况。此外，该亲水性聚合物利用其具有吸附性的亲水基团，将水溶性的胶原蛋白或透明质酸液等促进伤口愈合的化合物，吸附至亲水性聚合物内部的三维网络结构，在伤口治疗时能缓释促进伤口愈合因子，能加速伤口愈合。此外，目前伤口处理，伤员需先涂敷伤口愈合化合物，再覆盖敷料，故需要二步骤的照护流程，但本发明的亲水性敷料可一步骤就达到上述的疗程目的，可使伤口愈合的时间能更有效地缩短。
为达上述的目的，本发明提供一种复合性材料，其包含一亲水性基材以及一促进伤口愈合的化合物，其中该亲水性基材为一亲水性聚合物的反应产物，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中该促进伤口愈合的化合物分布在该亲水性基材中。
本文中的用语「一」或「一种」是用以叙述本发明的组件及成分。此术语仅为了叙述方便及给予本发明的基本观念。此叙述应被理解为包括一种或至少一种，且除非明显地另有所指，表示单数时也包括复数。在在申请专利范围中和”包含”一词一起使用时，该用语「一」可意谓一个或超过一个。
本文中的用语「或」其意同「及/或」。
本文中的「亲水性单体」包含一具有亲水性基团的反应性单体。可用在制备本发明的亲水性聚合物的亲水性单体，其具有至少一个可聚合的双键与至少一个亲水性的官能性基团。具有可聚合双键的官能性基团，其实例包括：丙烯酸、甲基丙烯酸、丙烯酰胺基、甲基丙烯酰胺基、富马酸、马来酸、苯乙烯基、异丙烯基苯基、O-乙烯碳酸酯、O-乙烯胺基甲酸酯、烯丙基、O-乙烯乙酰基、与N-乙烯内酰胺、与N-乙烯酰胺基的双键。
合适本发明的亲水性单体的类型包含含丙烯酸或乙烯基的单体。用语「丙烯酸」或「含丙烯酸」的单体为含有下列丙烯酸基团的单体：(CH2＝CRCOX)，其中R为H或CH3，且X为O或N，其也已知为可迅速进行聚合反应的单体，例如N,N-二甲基丙烯酰胺(DMA)、甲基丙烯酸2-羟乙基酯(HEMA)、甲基丙烯酸甘油酯、2-羟乙基甲基丙烯基酰胺、聚乙二醇单甲基丙烯酸酯、甲基丙烯酸、其混合物与类似者。用语「乙烯基」或「含乙烯基」的单体是指含乙烯基基团(-CH＝CH2)且能够进行聚合反应的单体。含乙烯基单体，包括但不限于单体如N-乙烯酰胺、N-乙烯内酰胺(例如NVP)、N-乙烯基-N-甲基乙酰胺、N-乙烯基-N-乙基乙酰胺、N-乙烯基-N-乙基甲酰胺、N-乙烯基甲酰胺。
其他可用于本发明的亲水性单体包括但不限于聚氧乙烯多元醇，其具有一或多个经一含可聚合双键的官能基置换的末端羟基基团。实例包括聚乙二醇、乙氧基化烷基葡苷与乙氧基化双酚A，其与一或多个莫耳当量的封端基团(end-capping group)反应，例如甲基丙烯酸异氰基乙酯(IEM)、甲基丙烯酸酐、甲基丙烯酰氯、乙烯基苯甲酰氯或类似者，以产生具有一或多个末端可聚合烯基团的聚乙多元醇，并且该一或多个末端可聚合烯基团透过联结部分(linking moiety)，如胺基甲酸酯或酯基团键结至该聚乙多元醇。
本发明所述的亲水性单体可为任何已知可用于制造水凝胶的亲水性单体。在一具体实施例中，该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其衍生物或它们的组合。
在另一具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为8至80％。在一较佳具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为10至50％。
本发明的交联剂无特别限制，只要其能与该亲水性聚合物的官能基反应以引发交联作用即可。本文中「交联剂」包含但不限于具有至少两个烯系不饱和基团的化合物。在一具体实施例中，该交联剂包含一N,N'-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯中或它们的组合。
在另一具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.1至20％。在一较佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.2至10％。在一更佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.5至5％。
本发明通过在该亲水性聚合物中加入无机硅氧化合物，以提高该亲水性聚合物的反应产物的强度，即该亲水性基材，使该亲水性基材具有高强度三维网络结构，故克服以往水凝胶的结构因吸收水性溶液而膨润后易碎的情况。在一具体实施例中，该无机硅氧化合物为一以硅氧链为主链的化合物。硅氧链的基本结构单元是由硅-氧键结构成，具有能与无机材料进行化学性结合，也能够与有机材料进行化学性结合的反应基团。故无机硅氧化合物的结构中既具有"有机基团"结合能力，又含有"无机结构"，这种特殊组成与反应基团的结构，当与有机聚合单体进行反应时，其特殊物化性能起偶联反应，有效提高聚合材料的机械强度，耐水性，耐寒性，黏结度等。
本发明的该无机硅氧化合物包含一无机硅酸盐。无机硅酸盐是指由硅和氧组成的化合物(SixOy)，可用由二氧化硅或硅酸产生的盐表示。在一具体实施例中，该无机硅氧化合物为一二氧化硅或一金属硅酸盐。本文中「金属硅酸盐」一词是由硅元素、氧元素和金属元素组成的化合物的总称。该金属硅酸盐是指二氧化硅的硅氧键改以金属盐替换，其所产生的的金属硅酸盐的粒径小，比表面积大，原始单个粒子为0.02μm，聚集态粒子为5μm，集合体粒子为30μm，比表面积为20-800m2/g。当金属硅酸盐的比表面积大于50m2/g时，表面的硅醇基使粒子之间产生相互作用，在作为橡胶或塑料等疏水塑料聚合物的填料时，赋予塑料优良的补强作用。在一较佳具体实施例中，该金属硅酸盐为一硅酸镁铝。
粒子的比表面积是指单位质量(或体积)颗粒状物质的总表面积，可作为用以评价催化剂、吸附剂及其他多孔性物质性能的重要参数之一。因此，粒子的比表面积增大，可增大其吸附面积，从而增加其吸附能力。在一具体实施例中，该无机硅氧化合物的粒子的比表面积大于50m2/g。在一较佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于100m2/g。在一更佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于150m2/g。
在另一具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为2至80％。在一较佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为4至50％。在一更佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为6至40％。
在一具体实施例中，该无机硅氧化合物为一具有硅氧四面体结构或一聚硅氧四面体结构的无机化合物。因此，透过该无机硅氧化合物在该亲水性聚合物中聚合成三维网络结构，可提高该亲水性聚合物的强度。
该亲水性聚合物进一步包含一或多种聚合引发剂。该聚合引发剂以有效量在该亲水性聚合物中使用，以引发该亲水性聚合物的光聚合。该亲水性聚合物的聚合可使用加热、可见光、紫外光或其他方式的适当选择引发，取决于所使用的聚合引发剂。或者，可在没有光引发剂下引发，例如使用电子束(e-beam)。
该聚合引发剂的实例包括但不限于月桂基过氧化物、苯甲酰基过氧化物、过氧碳酸异丙酯、偶氮双异丁腈与类似者，其在中度升高的温度下会产生自由基，以及光引发剂系统如芳族阿伐羟基酮、烷氧基氧基安息香、苯乙酮、酰基膦氧化物、双酰基膦氧化物与三级胺加上二酮、前述物质的混合物与类似者。UV光聚合引发剂包含Irgacure 1173与Irgacure2959(Ciba Specialty Chemicals)。
因此，该聚合引发剂可促使该亲水性聚合物的其他成份彼此产生聚合反应，反应后以得一亲水性聚合物的反应产物，以作为该亲水性基材。
待上述亲水性基材固化后，利用其具有吸附性的亲水基团，将水溶性促进伤口愈合因子，吸附至该亲水性基材内部的三维网络结构，形成该复合性材料。因此，该复合性材料制成亲水性敷料后，将其贴附于伤口上时，该促进伤口愈合因子从该复合性材料释放出，可加速伤口愈合。
本文中的「伤口」可以是开放伤口和闭合伤口。开放伤口可以分为许多类型，包括割伤(由干净的锋利的物体如刀或剃刀引起)、裂口(由压力或撕扯引起的粗糙不规则的伤口)、擦伤(通常是由于滑过粗糙表面所引起的很表面的伤，其最上层的皮肤被擦掉)和刺伤(被一个物体例如钉或针刺破皮肤引起)。闭合伤口的分类少得多，但是同开放伤口一样危险。它们是挫伤或打伤(由硬力引起的皮肤下组织的伤害)、血肿(由血管受损使得血液在皮肤下聚集引起)以及压伤(由于长期施加的很大或极大的外力引起)。
本文中的「促进伤口愈合的化合物」包含但不限于具有促进伤口愈合的功效的化合物。在一具体实施例中，该促进伤口愈合的化合物包含一促进伤口愈合的水溶性化合物。在一较佳具体实施例中，该促进伤口愈合的化合物包含一促进伤口愈合因子。在一更佳具体实施例中，该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一藻酸盐、一银离子、一几丁聚糖或它们的组合。本文中「细胞因子」包含但不限于白细胞介素及干扰素。本文中「生长因子」包含但不限于上皮生长因子(epidermal growth factor；EGF)、纤维母细胞生长因子(fibroblast growth factor；FGF)、血管内皮生长因子(vascular endothelial growth factor；VEGF)、结缔组织生长因子(connective tissue growth factor)、血小板衍生性生长因子(platelet-derivedgrowth factor；PDGF)、类胰岛素生长因子(insulin-like growth factor)、神经生长因子(nerve growth factor)、细胞聚落刺激因子(colony-stimulating factor)、干细胞因子(stem call factor)、角质细胞生长因子(keratinocyte growth factor)、颗粒球细胞聚落刺激因子(granulocyte colony-stimulating factor)、颗粒球巨噬细胞聚落刺激因子(granulocyte macrophage colony-stimulating factor)、胶质衍生神经营养因子(glial-derived neurotropic factor)、内皮单核细胞活化多胜肽(endothelial-monocyte activating polypeptide)、上皮中性粒细胞活化胜肽(epithelial neutrophilactivating peptide)、红血球生成素(rythropoietin)、BRAK及转化生长因子-β(transforming growth factor beta)。
在另一具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.01至20％。在一较佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.05至18％。在一更佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.1至15％。
本发明的复合性材料进一步黏合一薄膜，以形成一亲水性敷料。在一具体实施例中，该薄膜具有两面结构，其中一面为一黏合面，该黏合面与该复合性材料黏合。在另一具体实施例中，该薄膜为一具有防水透气的功效的薄膜。在一较佳具体实施例中，该薄膜为一聚氨酯(Polyurethane；PU)薄膜。
在一具体实施例中，该薄膜的表面积大于该复合性材料的表面积。因此该薄膜的该黏合面会有多出黏合该复合性材料外的黏合区域，用以提供该亲水性敷料与肌肤黏合。在另一具体实施例中，该黏合面为一压克力胶黏合面。该压克力胶黏合面以用以黏合该复合性料以及一个体的皮肤。
本发明还提供一复合性材料的制备方法，其步骤包含：(1)交联聚合一亲水性聚合物，以得一亲水性基材，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物；以及(2)加入一促进伤口愈合的化合物于该亲水性基材中，以得该复合性材料，其中该促进伤口愈合的化合物被该亲水性基材所吸附且分布在该亲水性基材中。
在一具体实施例中，该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其衍生物或它们的组合。
在另一具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为8至80％。在一较佳具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为10至50％。
在一具体实施例中，该交联剂包含一N,N'-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯中或它们的组合。
在另一具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.1至20％。在一较佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.2至10％。在一更佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.5至5％。
在一具体实施例中，该无机硅氧化合物包含一无机硅酸盐。在一较佳具体实施例中，该无机硅氧化合物为一二氧化硅或一金属硅酸盐。在一更佳具体实施例中，该金属硅酸盐为一硅酸镁铝。
在另一具体实施例中，该无机硅氧化合物为一具硅氧四面体结构或一聚硅氧四面体结构的无机化合物。在另一具体实施例中，该无机硅氧化合物的粒子的比表面积大于50m2/g。在一较佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于100m2/g。在一更佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于150m2/g。
在一具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为2至80％。在一较佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为4至50％。在一更佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为6至40％。
本发明的制备方法中步骤(1)的该亲水性聚合物进一步包含一聚合引发剂。该聚合引发剂系以有效量在该亲水性聚合物中使用，以引发该亲水性聚合物的光聚合。该聚合引发剂的实例包括但不限于月桂基过氧化物、苯甲酰基过氧化物、过氧碳酸异丙酯、偶氮双异丁腈与类似者，其在中度升高的温度下会产生自由基，以及光引发剂系统如芳族阿伐羟基酮、烷氧基氧基安息香、苯乙酮、酰基膦氧化物、双酰基膦氧化物与三级胺加上二酮、前述物质的混合物与类似者。在一具体实施例中，该聚合引发剂为一UV光聚合引发剂。该UV光聚合引发剂是用UV光照射以引发聚合反应。在一较佳具体实施例中，该UV光聚合引发剂为Irgacure 1173或Irgacure 2959。
在一具体实施例中，交联聚合该亲水性聚合物的方法包含使用加热、可见光或紫外光的方式，使该亲水性聚合物产生交联聚合反应。
在另一具体实施例中，该促进伤口愈合的化合物包含一促进伤口愈合的水溶性化合物。在一较佳具体实施例中，该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一藻酸盐、一银离子、一几丁聚糖或它们的组合。
在一具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.01至20％。在一较佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.05至18％。在一更佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.1至15％。
因该亲水性基材本身具有亲水基团，故能吸附促进伤口愈合的化合物；且该亲水性基材为具有三维网络结构的固态亲水性聚合物，故该三维网络结构能缓释促进伤口愈合的化合物，加强该复合性材料的伤口愈合效果。
本发明所制备出的该复合性材料可进一步与一薄膜黏合，以得一亲水性敷料，用于伤口愈合。
本发明的薄膜可兼具有防水、透明与透气等特性；藉此，不仅可避免水或细菌进入该亲水性敷料内，同时也可保持良好透气性。在一具有体实施例中，该薄膜为一具有有防水透气的功效的薄膜。在一较佳具有体实施例中，该透气膜层可由聚氨酯(Polyurethane；PU)所制成。
此外，本发明的薄膜为一具有单面黏合剂的薄膜，除了与该复合性材料黏合外，也提供与一个体的肌肤黏合的作用。故在一具体实施例中，该薄膜具有两面结构，其中一面为一黏合面，该黏合面与该复合性材料黏合。在一较佳具体实施例中，该黏合面为一压克力胶黏合面。该压克力胶黏合面以用以黏合该复合性料以及一个体的皮肤。在另一具体实施例中，该薄膜的表面积大于该复合性材料的表面积。因此，该薄膜的该黏合面会有多出黏合该复合性材料以外的黏合区域，用以提供该亲水性敷料与一个体的肌肤黏合；而肌肤黏合区域为一供氧和湿气交换的密封环境，隔绝微生物与污染物进入伤口，以促进伤口处于潮湿而不过度浸润或干燥现象。
在一具体实施例中，该个体为动物，较佳为哺乳类，更佳为人类。
本发明进一步提供一种水凝胶结构，其包含一亲水性基材层以及复数个分子颗粒，其中该亲水性基材层由一亲水性聚合物所组成，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中该复数个分子颗粒分布在该亲水性基材层中，其中各该复数个分子颗粒为促进伤口愈合的化合物。
在一具体实施例中，该亲水性基材层具有一三维网络结构，该复数个分子颗粒黏附在该三维网络结构上。
在另一具体实施例中，该复数个分子颗粒的形状为圆球状。
在一具体实施例中，该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其衍生物或它们的组合。
在另一具体实施例中，该交联剂包含一N,N'-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯或它们的组合。
在一具体实施例中，该无机硅氧化合物为一具有硅氧四面体结构或一聚硅氧四面体结构的无机化合物。
在另一具体实施例中，该亲水性聚合物进一步包含一聚合引发剂。在一较佳具体实施例中，该聚合引发剂为一Irgacure 2959。
在一具体实施例中，该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一藻酸盐、一银离子、一几丁聚糖或它们的组合。
在另一具体实施例中，该水凝胶结构进一步黏合一薄膜层，其设在该水凝胶结构上方，且该薄膜层的表面积大于该水凝胶结构的表面积。在一较佳具体实施例中，该薄膜层具有两面结构，其中一面为一黏合面，该黏合面与该水凝胶结构黏合。在一更佳具体实施例中，该薄膜层的材质为一聚氨酯(PU)。
是以，本发明的主要目的在于，提供一种具有适当强度、弹性与三维网络结构的固态亲水性聚合物。该亲水性聚合物具有亲水基团，故具有吸湿及抗水解特性，可吸收伤口渗出液并维持伤口湿润；而适当强度的三维网络固态结构覆盖伤口，不仅隔绝外在环境防护伤口，更能加速伤口表皮细胞增生与移动，加速伤口愈合。
本发明的另一目的在于，此适当强度的固态亲水性聚合物，不需不织布或纤维作为强化其结构的支持层，又利用其具有的亲水基团，可吸附促进伤口愈合因子，并利用该亲水聚合物中的三维网络结构达到缓释促进伤口愈合因子的效果，加速伤口愈合。
附图说明
图1为本发明的复合性材料的结构示意图；
图2为本发明的亲水性敷料的侧面结构示意图；
其中，100、220：复合性材料；110：亲水性基材；120：伤口愈合有效因子；200：亲水性敷料；210：薄膜。
具体实施方式
下述范例具非局限性，且仅代表本发明的数个方面及特性。
本发明是以具亲水基团的反应性单体、交联剂及硅氧四面体结构的化合物，固化聚合形成不溶在水的高强度固态的亲水性聚合物，再利用亲水性聚合物基材本身的亲水基团的吸附特性，将伤口愈合有效因子，吸附于固态三维网络结构的亲水性聚合物中。
实施例1
亲水性聚合物的制备
将3克丙烯酰胺(亲水性单体)、7克2-丙烯酰胺基-2-甲基丙磺酸(亲水性单体)、2克二氧化硅、N,N'-亚甲基双丙烯酰胺(添加量为亲水性聚合物的总重量的1％)(交联剂)与水混合至100克，并搅拌均匀。
将上述溶液除氧气后，再向溶液中加入引发剂(initiator)Irgacure 2959(添加量为亲水性聚合物的总重量的2％)并搅拌均匀。将溶液移至反应模具中，在紫外光照射的情况下，使反应模具中的溶液开始发生交联聚合，溶液中液态低聚物逐渐形成不溶于水的固态的三维网络结构的亲水性聚合物，以作为一亲水性基材。
实施例2
复合性材料的制备
添加10克的10％胶原蛋白溶液，其为伤口愈合有效因子，在上述固态的亲水性聚合物中。待固态的亲水性聚合物将胶原蛋白溶液完全吸附后，即可获得一复合性材料。
如图1所示，其为本发明的复合性材料100的结构示意图，该复合性材料100包含一亲水性基材110以及一伤口愈合有效因子120。该亲水性基材110为一亲水性聚合物的反应产物，其具有三维网络结构的固态物，其中该亲水性聚合物包含一亲水性单体、一交联剂及一无机硅氧化合物。而该伤口愈合有效因子120则分布在该亲水性基材110的三维网络结构中；在将该复合性材料100用于治疗伤口时，该伤口愈合有效因子120可在该复合性材料100中所释放，可加速伤口愈合。该伤口愈合有效因子120的一具体实施例为胶原蛋白。
实施例3
复合性材料的功效测试
本发明依据上述复合性材料的制备方法，仅调整亲水性聚合物中二氧化硅的部分的添加量或将二氧化硅改以其他成份替代，即原先3克丙烯酰胺、7克2-丙烯酰胺基-2-甲基丙磺酸、和N,N'-亚甲基双丙烯酰胺(其添加量为亲水性聚合物的总重量的1％)的成份及添加量不变动，以制备出四种不同的复合性材料的样本。各个样本的制备方法差别如下：样本1：二氧化硅的添加量为2克；样本2：二氧化硅的添加量为6克；样本3：二氧化硅以硅酸镁铝替代，且其添加量为2克；以及样本4：二氧化硅以硅酸镁铝替代，且其添加量为6克。
将上述四种配比不同的复合性材料样本与市面上贩卖的水凝胶敷料(作为对比组)进行比较，分别量测其浸生理食盐水前与浸渍完全膨润后的力学性质，其测试结果如表1所示。
表1、本发明的四种复合性材料样本与对比组的比较测试结果
实施例4
亲水性敷料的制备
将一单面黏合剂的薄膜(例如市售的”舒敷贴”，其具有防水透气的功能)与上述的复合性材料黏合，即将该薄膜上具有黏合剂的那一面贴合该复合性材料，就可得一亲水性敷料。
如图2所示，其为本发明的亲水性敷料200的侧面结构示意图，该亲水性敷料200包含一薄膜210以及一复合性材料220，其中该薄膜210设在该复合性材料220上方。该薄膜210具有两面结构，其中一面为一黏合面(黏合面未绘示)，该黏合面上具有黏合剂，该黏合面会与该复合性材料220黏合，以使该薄膜210以及该复合性材料220组成该亲水性敷料200。此外，该薄膜210的表面积大于该复合性材料220的表面积，因此该薄膜210的该黏合面会有多出黏合该复合性材料220外的黏合面积，用以提供该亲水性敷料200与一个体的肌肤黏合，而肌肤黏合区域为一供氧和湿气交换的密封环境，隔绝微生物与污染物进入伤口，以促进伤口处于潮湿而不过度浸润或干燥现象。
上述实施例仅为例示性说明本发明的功效，并阐述本发明的技术特征，而非用于限制本发明的保护范畴。任何熟悉本技术者在不违背本发明的技术原理及精神下，可轻易完成的改变或安排，均属本发明所主张的范围。因此，本发明的权利保护范围系如后附申请专利范围所列。
Claims (9)
1.一种复合性材料，其包含一亲水性基材以及一促进伤口愈合的化合物，其中该亲水性基材为一亲水性聚合物的反应产物，其中该亲水性聚合物是由一亲水性单体、一交联剂、一聚合引发剂、一金属硅酸盐以及水所制成，其中该促进伤口愈合的化合物分布在该亲水性基材中，该亲水性单体具有至少一个可聚合的双键与至少一个亲水性的官能性基团。
2.如权利要求1所述的复合性材料，其中该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一具有一或多个经一含可聚合双键的官能基置换的末端羟基基团的聚乙二醇或其衍生物或它们的组合。
3.如权利要求1所述的复合性材料，其中该亲水性单体占该亲水性聚合物的重量百分比为8至80％。
4.如权利要求1所述的复合性材料，其中该交联剂包含一N,N'-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯或它们的组合。
5.如权利要求1所述的复合性材料，其中该交联剂占该亲水性聚合物的重量百分比为0.1至20％。
6.如权利要求1所述的复合性材料，其中该金属硅酸盐占该亲水性聚合物的重量百分比为2至80％。
7.如权利要求1所述的复合性材料，其中该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子、一藻酸盐、一银离子、一几丁聚糖或它们的组合。
8.如权利要求1所述的复合性材料，其中该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.01至20％。
9.如权利要求1所述的复合性材料，其进一步黏合一薄膜，其中该薄膜具有两面结构，其中一面为一黏合面，该黏合面与该复合性材料黏合，且该薄膜的表面积大于该复合性材料的表面积。
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710248691.0A CN108721677B (zh) | 2017-04-17 | 2017-04-17 | 复合性材料 |
| US16/605,498 US11235083B2 (en) | 2017-04-17 | 2018-01-24 | Composite hydrogel and metal silicate wound healing material |
| KR1020197031607A KR102377115B1 (ko) | 2017-04-17 | 2018-01-24 | 복합 재료 |
| PCT/CN2018/074042 WO2018192285A1 (zh) | 2017-04-17 | 2018-01-24 | 复合性材料 |
| JP2019556222A JP2020516667A (ja) | 2017-04-17 | 2018-01-24 | 複合材料 |
| EP18788094.3A EP3613444A4 (en) | 2017-04-17 | 2018-01-24 | COMPOSITE MATERIAL |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710248691.0A CN108721677B (zh) | 2017-04-17 | 2017-04-17 | 复合性材料 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108721677A CN108721677A (zh) | 2018-11-02 |
| CN108721677B true CN108721677B (zh) | 2021-11-19 |
Family
ID=63856127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710248691.0A Active CN108721677B (zh) | 2017-04-17 | 2017-04-17 | 复合性材料 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11235083B2 (zh) |
| EP (1) | EP3613444A4 (zh) |
| JP (1) | JP2020516667A (zh) |
| KR (1) | KR102377115B1 (zh) |
| CN (1) | CN108721677B (zh) |
| WO (1) | WO2018192285A1 (zh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
| GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| US10207031B2 (en) | 2010-12-08 | 2019-02-19 | Convatec Technologies Inc. | Integrated system for assessing wound exudates |
| EP2648794B1 (en) | 2010-12-08 | 2019-08-28 | ConvaTec Technologies Inc. | Wound exudate system accessory |
| US10780200B2 (en) | 2010-12-08 | 2020-09-22 | Convatec Technologies Inc. | Method and system for removing exudates from a wound site |
| GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
| GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
| CN105008611A (zh) | 2012-12-20 | 2015-10-28 | 康沃特克科技公司 | 化学改性的纤维素纤维的处理 |
| US11740241B2 (en) | 2016-03-30 | 2023-08-29 | Synovo Gmbh | Construct including an anchor, an enzyme recognition site and an indicator region for detecting microbial infection in wounds |
| SG11201808488XA (en) | 2016-03-30 | 2018-10-30 | Convatec Technologies Inc | Detecting microbial infections in wounds |
| EP3481348A4 (en) | 2016-07-08 | 2020-02-26 | ConvaTec Technologies Inc. | FLUID COLLECTION APPARATUS |
| US11452808B2 (en) | 2016-07-08 | 2022-09-27 | Convatec Technologies Inc. | Fluid flow sensing |
| CA3030152A1 (en) | 2016-07-08 | 2018-01-11 | Convatec Technologies Inc. | Flexible negative pressure system |
| CN111836655A (zh) | 2017-11-16 | 2020-10-27 | 康沃特克有限公司 | 流体收集设备 |
| CN109331216B (zh) * | 2018-11-28 | 2021-03-30 | 福建师范大学 | 一种快速止血水凝胶及其制备方法 |
| CN113939321A (zh) | 2019-06-03 | 2022-01-14 | 康沃特克有限公司 | 破坏和控制病原体的方法和装置 |
| TW202102273A (zh) * | 2019-07-10 | 2021-01-16 | 美麗康生技股份有限公司 | 防水透氣濕式敷料 |
| US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
| US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0524786A1 (en) * | 1991-07-18 | 1993-01-27 | MITSUI TOATSU CHEMICALS, Inc. | Hardenable compositions, aqueous gels and processes of making them and applications of said gels |
| WO2005065736A2 (en) * | 2003-12-22 | 2005-07-21 | 3M Innovative Properties Company | Silicone pressure sensitive adhesive and articles |
| CN101240052A (zh) * | 2008-02-29 | 2008-08-13 | 厦门大学 | 一种丙烯酸系半互穿网络复合型高吸水性树脂的制备方法 |
| CN102186508A (zh) * | 2008-10-20 | 2011-09-14 | 赢创斯托豪森有限责任公司 | 包含粘土的超吸收性聚合物、微粒及其制备方法 |
| US8552071B1 (en) * | 1998-11-26 | 2013-10-08 | Basf Se | Hydrogels absorbing aqueous fluids |
| CN105980042A (zh) * | 2014-02-24 | 2016-09-28 | 日产化学工业株式会社 | 凝胶的制造方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093673A (en) * | 1974-11-14 | 1978-06-06 | Ppg Industries, Inc. | Coating compositions composed of hydroxyfunctional polymers or copolymers and alkoxysilanes |
| US4950699A (en) * | 1988-01-11 | 1990-08-21 | Genetic Laboratories, Inc. | Wound dressing incorporating collagen in adhesive layer |
| US5977088A (en) | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| GB2272645B8 (en) * | 1992-11-23 | 2010-02-10 | Johnson & Johnson Medical | Wound dressing |
| US5489304A (en) | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
| US5725876A (en) * | 1996-05-17 | 1998-03-10 | Noven Pharmaceuticals Inc., | Compositions and methods for using low-swell clays in nicotine containing dermal compositions |
| JP3770752B2 (ja) | 1998-08-11 | 2006-04-26 | 株式会社日立製作所 | 半導体装置の製造方法及び加工装置 |
| CA2310484A1 (en) * | 1999-05-26 | 2000-11-26 | Alberta Research Council Inc. | Networked polymer/clay alloy |
| EP1192319B1 (en) * | 1999-05-26 | 2003-12-03 | Alberta Research Council, Inc. | Reinforced networked polymer/clay alloy composite |
| TWI264306B (en) | 2000-08-02 | 2006-10-21 | Shin Era Technology Co Ltd | Wound dressings and their preparation |
| WO2002087645A1 (en) * | 2001-05-01 | 2002-11-07 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions |
| EP1437380B1 (en) * | 2001-09-18 | 2010-04-28 | Sekisui Plastics Co., Ltd. | Polymeric hydrogel |
| TW504420B (en) | 2002-02-27 | 2002-10-01 | Advanced Semiconductor Eng | Table saw device |
| DE60332750D1 (en) * | 2002-10-02 | 2010-07-08 | Coloplast As | Hydrogel |
| TWI267387B (en) | 2003-02-20 | 2006-12-01 | Inst Nuclear Energy Res Aec | The novel preparation of two-layer burn wound dressings |
| DE10331456A1 (de) * | 2003-07-10 | 2005-02-24 | Basf Ag | (Meth)acrylsäureester alkoxilierter ungesättigter Polyolether und deren Herstellung |
| JP4567998B2 (ja) * | 2004-03-22 | 2010-10-27 | コスメディ製薬株式会社 | 親水性粘着剤を用いた親水性皮膚外用粘着剤組成物および親水性貼付剤 |
| RU2393877C2 (ru) * | 2004-08-05 | 2010-07-10 | Кориум Интернэшнл, Инк. | Адгезивная композиция |
| RU2411045C2 (ru) * | 2005-01-27 | 2011-02-10 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Ран | Гидрофильные биологически совместимые адгезивные композиции и их применение |
| JP2006321792A (ja) * | 2005-04-18 | 2006-11-30 | Showa Denko Kk | 含水ゲル体及びその製造方法 |
| EP1837348B9 (en) * | 2006-03-24 | 2020-01-08 | Nippon Shokubai Co.,Ltd. | Water-absorbing resin and method for manufacturing the same |
| US7981949B2 (en) * | 2006-05-23 | 2011-07-19 | 3M Innovative Properties Company | Curable hydrophilic compositions |
| CN101195664B (zh) * | 2006-12-06 | 2012-01-04 | 新疆大学 | 有机无机复合型半互穿网络结构超强吸水剂的制备方法 |
| AU2007359585A1 (en) * | 2007-09-27 | 2009-04-02 | Sca Hygiene Products Ab | Claylinked polymer gels |
| CN101125934B (zh) * | 2007-09-30 | 2010-05-19 | 四川大学 | 含银离子的壳聚糖/尼龙复合抗菌膜的制备方法 |
| CN101959538A (zh) * | 2008-03-05 | 2011-01-26 | 巴斯夫欧洲公司 | 制备超吸收剂的方法 |
| CN101712785A (zh) * | 2008-10-06 | 2010-05-26 | 常琛 | 新型高吸水树脂/无机纳米粒子复合材料及其制备方法和用途 |
| CN101735353B (zh) * | 2010-01-07 | 2012-12-05 | 华南理工大学 | N-乙烯基酰胺类聚合物和锂藻土复合水凝胶及制备方法 |
| JP5688578B2 (ja) * | 2010-11-17 | 2015-03-25 | アルケア株式会社 | 粘着性ゲル |
| TWM419555U (en) | 2011-04-28 | 2012-01-01 | Amed Co Ltd | Wound dressing |
| US10159605B2 (en) | 2011-09-15 | 2018-12-25 | Compose Element Limited | Dressing |
| KR101335176B1 (ko) * | 2011-12-12 | 2013-11-29 | 테고사이언스 (주) | 상처 치유용 드레싱재제 |
| WO2015001564A1 (en) * | 2013-07-04 | 2015-01-08 | Yeda Research And Development Co. Ltd. | Low friction hydrogels and hydrogel-containing composite materials |
| KR101719352B1 (ko) * | 2013-12-13 | 2017-04-04 | 주식회사 엘지화학 | 고흡수성 수지 조성물 |
| AU2015271615A1 (en) * | 2014-06-04 | 2016-12-08 | Klox Technologies Inc. | Biophotonic hydrogels |
| KR20160004967A (ko) * | 2014-07-04 | 2016-01-13 | 한화케미칼 주식회사 | 고흡수성 수지 및 이의 제조 방법 |
| CN104262881B (zh) * | 2014-10-10 | 2017-10-24 | 齐鲁工业大学 | 一种高强度双网络纳米二氧化硅复合水凝胶的制备方法 |
| CN105561370B (zh) * | 2015-04-28 | 2019-02-15 | 安徽省科晟生物科技有限公司 | 一种止血材料及其制备方法 |
| CN204863670U (zh) | 2015-08-20 | 2015-12-16 | 振朋生技股份有限公司 | 多层贴布结构 |
| WO2017058698A1 (en) * | 2015-09-30 | 2017-04-06 | 3M Innovative Properties Company | Hydrogel compositions bonded to polymeric substrates |
| CN105169460B (zh) * | 2015-10-26 | 2018-09-25 | 广东泰宝医疗科技股份有限公司 | 一种磁疗抗菌止血敷料及其制备方法 |
-
2017
- 2017-04-17 CN CN201710248691.0A patent/CN108721677B/zh active Active
-
2018
- 2018-01-24 JP JP2019556222A patent/JP2020516667A/ja active Pending
- 2018-01-24 EP EP18788094.3A patent/EP3613444A4/en not_active Withdrawn
- 2018-01-24 WO PCT/CN2018/074042 patent/WO2018192285A1/zh active Search and Examination
- 2018-01-24 US US16/605,498 patent/US11235083B2/en active Active
- 2018-01-24 KR KR1020197031607A patent/KR102377115B1/ko active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0524786A1 (en) * | 1991-07-18 | 1993-01-27 | MITSUI TOATSU CHEMICALS, Inc. | Hardenable compositions, aqueous gels and processes of making them and applications of said gels |
| US8552071B1 (en) * | 1998-11-26 | 2013-10-08 | Basf Se | Hydrogels absorbing aqueous fluids |
| WO2005065736A2 (en) * | 2003-12-22 | 2005-07-21 | 3M Innovative Properties Company | Silicone pressure sensitive adhesive and articles |
| CN101240052A (zh) * | 2008-02-29 | 2008-08-13 | 厦门大学 | 一种丙烯酸系半互穿网络复合型高吸水性树脂的制备方法 |
| CN102186508A (zh) * | 2008-10-20 | 2011-09-14 | 赢创斯托豪森有限责任公司 | 包含粘土的超吸收性聚合物、微粒及其制备方法 |
| CN105980042A (zh) * | 2014-02-24 | 2016-09-28 | 日产化学工业株式会社 | 凝胶的制造方法 |
Non-Patent Citations (3)
| Title |
|---|
| "Preparation of an imogolite/poly(acrylic acid) hybrid gel";Hoik Lee et al;《Journal of Colloid and Interface Science》;20130607;第406卷;第165-171页 * |
| "物理/化学复合交联剂配比对凝胶温敏性的影响";张青松等;《功能材料》;20121231;第43卷;第558-563页 * |
| "聚N-异丙基丙烯酰胺/黏土纳米复合自修复水凝胶的制备及性能";李海燕等;《中国塑料》;20151231;第29卷;第18-22页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018192285A1 (zh) | 2018-10-25 |
| JP2020516667A (ja) | 2020-06-11 |
| CN108721677A (zh) | 2018-11-02 |
| EP3613444A4 (en) | 2021-01-06 |
| KR102377115B1 (ko) | 2022-03-22 |
| KR20190131099A (ko) | 2019-11-25 |
| EP3613444A1 (en) | 2020-02-26 |
| US20200114039A1 (en) | 2020-04-16 |
| US11235083B2 (en) | 2022-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108721677B (zh) | 复合性材料 | |
| JP3532235B2 (ja) | ヒドロゲルラミネート、絆創膏、複合体、およびそれらの製造法 | |
| US10688215B2 (en) | Flexible hydrogel wound dressings | |
| CN110240712A (zh) | 一种组织粘合用的高拉伸、高粘性、自愈合双网络水凝胶及其制备方法和应用 | |
| WO2009073401A4 (en) | Silicone hydrogels for tissue adhesives and tissue dressing applications | |
| US20090280182A1 (en) | Devices for the treatment of wounds and methods and kits therefor | |
| US20070282237A1 (en) | Absorbent materials and articles | |
| JPS6236702B2 (zh) | ||
| JP2003522596A (ja) | 創傷包帯用の表面模様付き吸収剤物品 | |
| US20050287191A1 (en) | Hydrogel composites | |
| CN112999412B (zh) | 用于伤口愈合的水凝胶敷料及其制备方法 | |
| CA2532493A1 (en) | Tissue substitute material | |
| EP2904038B1 (en) | Hydrogel composites | |
| JP2009270032A (ja) | ハイドロゲルおよびその製造方法 | |
| CN113616851B (zh) | 一种壳聚糖/聚2-甲基丙烯酰氧乙基三甲基氯化铵水凝胶 | |
| JP2011001482A (ja) | 高分子ゲル、高分子ゲル分散液、高分子ゲル複合体及びそれらの製造方法 | |
| TWI662072B (zh) | 複合性材料 | |
| JPS6397677A (ja) | 多孔性感圧接着剤フィルム物品およびその製造方法 | |
| TWM559888U (zh) | 水凝膠結構 | |
| CN111548454A (zh) | 可打印成型的高强度体温释放药物水凝胶的制备方法 | |
| JP2007117275A (ja) | 創傷被覆材 | |
| EP3316918A1 (en) | Hydrogel-foam patch for oxygen-delivery and method of manufacture | |
| White et al. | Blurring the Line Between Device and Drug by Targeting the Fibrin Blood Clot Niche | |
| JPH10277141A (ja) | 創傷被覆材 | |
| WO2017040091A1 (en) | Products for sealing wounds using compressed materials and flexible absorbent binders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200715 Address after: Room E002, Yuegui building, east exit of Wuzhou City, Guangxi Zhuang Autonomous Region Applicant after: Guangxi beautiful skin medical equipment Co., Ltd Address before: 4 / F, 34 Yongping street, Xindian District, Xinbei City, Taiwan, China Applicant before: Wang Wanting |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |