CN108309873B - Activation-balanced conditioning essence - Google Patents
Activation-balanced conditioning essence Download PDFInfo
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- CN108309873B CN108309873B CN201810426253.3A CN201810426253A CN108309873B CN 108309873 B CN108309873 B CN 108309873B CN 201810426253 A CN201810426253 A CN 201810426253A CN 108309873 B CN108309873 B CN 108309873B
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- 229960004441 tyrosine Drugs 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses an activation-balanced conditioning essence which comprises butanediol, propylene glycol, trehalose, hyaluronic acid, a centella asiatica extract, a rosemary leaf extract, panthenol, 1, 2-pentanediol, a geranium extract, ethylhexyl glycerin, a skin conditioner, a whitening agent, an antioxidant and water. The activation-promoting balanced conditioning essence disclosed by the invention is wide in raw material source, simple in processing technology, low in production cost, free of hormone, and suitable for various skin types, and has the effects of anti-allergy repair, whitening, freckle removal, skin tightening, skin aging delaying, moisture retention and the like.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an activation-balancing conditioning essence.
Background
With the increasing living standard of people, the pursuit of beauty is increasing, and various cosmetics are used for skin care. The cosmetics can be generally used for skin care aspects including cleaning, moisturizing, whitening and the like, and the main types of the cosmetics comprise facial cleanser, toner, lotion, essence, eye cream, functional whitening cream and the like. The essence is a transparent liquid cosmetic, can be divided into anti-allergy repair essence, whitening and freckle removing essence, anti-wrinkle essence, skin softening essence and the like, and can supplement moisture and nutrition to skin, so that the skin aging is delayed, the wrinkles are reduced, and the young state of the skin is kept.
The essence is a skin care product with the highest content of nutrient elements and the best effect, is expensive in the market of the skin care product, generally, consumers after 25 years old can select the essence to maintain the skin, and the essence is a daily necessity for people paying attention to maintenance. The efficacy of the essence is closely related to the components of the essence, and as modern people live increasingly more delicately, the environment also worsens increasingly, and the skin of the face of people is increasingly sensitive to various stimuli. The traditional method has a lot of adverse reactions to chemicals, and the existing pure plant products can also generate anaphylactic reaction to cause red, swollen, cancer and itching of facial skin and destroy the natural barrier of the skin, and skin cells need to be maintained and repaired in time in order to maintain the health of the skin and keep the skin soft and elastic. With the increase of age, the metabolism of the body is slowed down, the melanin can not be normally excreted, and spots are deposited on the horny layer to form chloasma, black spots and color spots, in addition, the modern life is tense, work and rest are irregular, and various environmental pollutions cause the resistance of the body to be reduced, endocrine dyscrasia, the activation of free radicals in the body and the abnormal secretion of the melanin are increased. Moreover, for some consumers with natural dark skin, whitening is a continuous pursuit. Therefore, whitening and removing spots have long been the goal of most beauty consumers, especially in China with white as the beauty. The skin aging refers to rough skin surface and wrinkle, the natural aging is mainly caused by the genetic factors of the organism and limited to the whole body, and is obviously characterized by the phenomena of wrinkle, relaxation, pigmentation and the like; photoaging is mainly skin aging caused by accumulation of ultraviolet damage, is the result of combined action of natural aging and ultraviolet irradiation, is limited to exposed parts of the skin, and is mainly characterized by phenomena of rough and lusterless skin, deepened pigmentation, elastic tissue deformation, synthesis capacity of collagen and elastin, reduction of immunity and the like.
Although the essence as an extreme product in cosmetics has the effects of anti-allergy repair, whitening, freckle removal, anti-aging, wrinkle resistance, moisture retention and the like, at present, no effective comprehensive treatment product exists for various skin problems, and a single-performance product has a good effect but cannot solve various skin problems of the same patient; in addition, the overlapping use of multiple single-performance products may not only have respective effects, but also may generate cross reaction, causing further serious skin problems.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the revitalizing and balancing conditioning essence.
A conditioning essence for activating balance comprises butanediol, propylene glycol, trehalose, hyaluronic acid, herba Centellae extract, herba Rosmarini officinalis leaf extract, panthenol, 1, 2-pentanediol, flos Pelargonii Graveolentis extract, ethylhexyl glycerol, skin conditioner, whitening agent, antioxidant, and water.
Specifically, the activating balance conditioning essence consists of the following raw materials in parts by weight: 9-13 wt% of butanediol, 3-10 wt% of propylene glycol, 2-4 wt% of trehalose, 0.2-1 wt% of hyaluronic acid, 0.05-1 wt% of centella asiatica extract, 0.1-0.5 wt% of rosemary leaf extract, 0.05-0.5 wt% of panthenol, 0.05-0.4 wt% of 1, 2-pentanediol, 0.01-0.05 wt% of geranium extract, 0.1-0.5 wt% of ethylhexyl glycerin, 4-12 wt% of a skin conditioner, 2-5 wt% of a whitening agent, 0.5-3 wt% of an antioxidant and the balance of water.
The skin conditioner is prepared from the following raw materials in parts by weight: 20-32 wt% of aloe extract, 10-15 wt% of licorice extract, 20-25 wt% of senecio cineraria extract, 10-20 wt% of peony root extract, 15-21 wt% of honeysuckle extract and 2-10 wt% of ceramide.
The whitening agent is one or more of glycyrrhiza glabra root extract, polygonum cuspidatum root extract and jackfruit peel extract.
Preferably, the whitening agent is a mixture of a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract, and the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract to the jackfruit peel extract is (1-5): (1-5): (1-5).
The antioxidant is one or more of tocopherol, tea extract and radix Scutellariae extract.
Preferably, the antioxidant is a mixture of tocopherol, tea extract and scutellaria root extract, and the mass ratio of the tocopherol to the tea extract to the scutellaria root extract is (1-5): (1-5): (1-5).
The ceramide is one or more of ceramide 1, ceramide 2 and ceramide 6 II.
The preparation method of the aloe extract comprises the following steps:
cleaning, airing, peeling and dicing aloe, and putting the aloe into hot water at 90-100 ℃ for fixation to obtain the aloe after fixation;
II, draining, drying and crushing the de-enzymed aloe to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and uniformly mixing, wherein the mass volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: (0.05-0.5): (10-15) (g/g/ml), extracting by microwave radiation, and filtering to obtain an extracting solution;
IV, performing ultrafiltration on the extracting solution to obtain ultrafiltrate;
and V, drying the ultrafiltrate by adopting a spray drying method to obtain the aloe extract.
Preferably, the preparation method of the aloe extract comprises the following steps:
cleaning, airing, peeling and dicing aloe, and putting the aloe into hot water at 90-100 ℃ for fixation to obtain the aloe after fixation;
II, draining, drying and crushing the de-enzymed aloe to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and uniformly mixing, wherein the mass volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: (0.05-0.5): (10-15) (g/g/ml), extracting by microwave radiation, and filtering to obtain an extracting solution a and aloe filter residue;
and IV, adding the aloe filter residue into an enzyme and phosphoric acid buffer solution, and uniformly mixing, wherein the mass volume ratio of the aloe filter residue to the enzyme to the phosphoric acid buffer solution is 1: (0.05-0.5): (10-15) (g/g/ml), extracting by ultrasonic, and filtering to obtain an extracting solution b;
mixing the extracting solution a and the extracting solution b, and performing ultrafiltration on the obtained mixed extracting solution to obtain ultrafiltrate;
VI, drying the ultrafiltrate by a spray drying method to obtain the aloe extract.
The enzyme is cellulase or/and protease.
Preferably, the enzyme is a mixture of cellulase and protease, and the mass of the cellulase and the protease is (1-3): (1-3).
The pH value of the phosphoric acid buffer solution ranges from 4 to 6.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, and uniformly stirring at 65-85 ℃ to obtain a mixture;
and III, cooling the mixture to 35-50 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent and an antioxidant, uniformly stirring, cooling to 25-35 ℃, standing for 18-35h, and discharging to obtain the activity-activating balance conditioning essence disclosed by the invention.
The use method of the invention comprises the following steps: after cleaning the face, a proper amount of the powder is gently massaged on the face until the powder is absorbed, and the powder is used twice a day. The essence can also be dripped into other cosmetics, and the using effect is better.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following beneficial effects: the anti-allergy moisturizing repair essence reduces allergens by mixing a plurality of plant components, has small irritation to skin, accelerates the repair and update of cells by stimulation while strengthening the natural resistance of the skin, and has the effects of improving and conditioning sensitive skin; the essence disclosed by the invention can effectively inhibit the activity of tyrosinase, efficiently remove oxygen radicals, prevent melanin from being generated, and has the effects of efficiently whitening and removing freckles; the antioxidant can effectively prevent skin photoaging, promote the generation of skin beautifying components such as collagen and the like, and achieve the effects of increasing skin elasticity, improving skin vitality and the like. The activation-promoting balanced conditioning essence disclosed by the invention is wide in raw material source, simple in processing technology, low in production cost, free of hormone, and suitable for various skin types, and has the effects of anti-allergy repair, whitening, freckle removal, skin tightening, skin aging delaying, moisture retention and the like.
Detailed Description
The foregoing summary of the invention is provided in the context of the present invention in which exemplary embodiments are shown and described, and in which all equipment and materials are commercially available or commonly used in the art, unless otherwise specified, and the methods in the examples which follow are conventional in the art, unless otherwise specified.
Introduction of raw materials and equipment in the examples:
potassium dihydrogen phosphate, CAS No.: 7778-77-0, product number: p104075 available from Shanghai Allantin Biotechnology Ltd.
Disodium hydrogen phosphate dihydrate, CAS No.: 10028-24-7, product number: s821245, available from Shanghai Michelin Biochemical technology, Inc.
Centella asiatica, a dry whole plant of Centella asiatica (L.) agrb. of the family umbelliferae, produced in china, purchased from certified trade ltd.
Rosemary leaves, which are leaves of Rosmarinus officinalis of Labiatae, variety Rosmarinus officinalis, which is purchased from Rosemary planting, Inc. of Yu jin Yu, City.
Pelargonium graveolens, leaves of Pelargonium graveolens L' Herit of Pelargonium genus of Geraniaceae family, produced in Yunnan, was purchased from Pelargonium graveolens ecological agriculture development Co., Ltd.
Licorice, a dry root of Glycyrrhiza uralensis fisch, a plant of Glycyrrhiza genus of leguminosae, produced in xinjiang, purchased from moja, china, the pharmaceutical industry ltd.
Dendranthema indicum, a flower bud of the perennial herb Matricaria chamomilla of the Compositae family, produced in Germany, was purchased from Yuntang tea, Inc., Bozhou.
Peony root, a dried root of Paeonia suffruticosa Andr. of Ranunculaceae, variety of Acer palmatum, Cat. 00116, purchased from Jingyao ShangMao Co., Ltd.
Honeysuckle, also known as honeysuckle, honeysuckle and honeysuckle, is the flower bud of the perennial twining woody liana Lonicera japonica of Caprifoliaceae, variety Henan Jiangqihua, purchased from Haitai chrysanthemum Limited of Tongxiang city.
Glycyrrhiza glabra root, dried root of Glycyrrhiza glabra L. of Leguminosae, Gansu, is purchased from Zhenghengzhiza soil production, LLC of Ministry county.
Polygonum cuspidatum root, which is the dried rhizome and root of Polygonum cuspidatum Sieb. et Zucc. of Polygonaceae, is purchased from Tai Sheng pharmaceutical Co., Ltd., Bozhou province, Hubei province.
Jack fruit peel, a peel of Artocarpus heterophyllus lam of Artocarpus of Moraceae, Hainan, was purchased from Dahurian province of fresh fruit edge agriculture, cooperative, Vaozhou, Japan.
Tocopherol, CAS number: 59-02-9, cosmetic grade, available from basf, Germany.
Tea, which is the leaf of Camellia sinensis (L.) o.ktze. of the genus Camellia of the family theaceae, is a species longjing, and is purchased from hang zhou longsancha limited.
Scutellaria baicalensis Georgi, dried root of Scutellaria baicalensis Georgi of Labiatae, variety Scutellaria baicalensis Georgi, purchased from Qixin pharmaceutical sales, Inc., Bozhou.
Butanediol, CAS number: 107-88-0, cosmetic grade, available from Pentium, Guangzhou, Pentium, chemical Co., Ltd.
Propylene glycol, CAS No.: 57-55-6, cosmetic grade, available from Wuhan Dynasty Co.
Trehalose, CAS No.: 99-20-7, cosmetic grade, purchased from zhengzhou Wangbu chemical products Co.
Hyaluronic acid, CAS No.: 9004-61-9, cosmetic grade, available from Zhengzhou Wangbu chemical products Co., Ltd.
Panthenol, CAS No.: 81-13-0, cosmetic grade, available from basf, Germany.
Ethylhexyl glycerol, CAS No.: 70445-33-9, cosmetic grade, available from Lossen chemical Co., Ltd, Linyi
1, 2-pentanediol, CAS No.: 5343-92-0, cosmetic grade, available from Guangzhou Yukung chemical Co., Ltd.
Ceramide, CAS No.: 100403-19-8, product number: c837835, available from Shanghai Michelin Biochemical technology, Inc.
Cellulase, CAS number: 9042-54-8, and the enzyme activity is 20000U/g, and is purchased from Shandong Su Kehan bioengineering GmbH.
Protease, CAS No.: 9001-75-6, which is prepared from pepsin P6322 provided by Shanghai Michelin Biotechnology Ltd, and has enzyme activity of 3000U/mg.
D101 macroporous resin, available from Hebei Gallery vast Yang chemical Co.
A phi 30mm x 500mm resin column, model MCSS-500, available from Beijing Kayaku technology Ltd.
The preparation method of the phosphoric acid buffer solution comprises the following steps: 27.22g of monopotassium phosphate is weighed, dissolved by water and diluted to 1000mL to obtain 0.2mol/L potassium dihydrogen phosphate solution; weighing 35.6g of disodium hydrogen phosphate dihydrate, dissolving with water and diluting to 1000mL to obtain 0.2mol/L disodium hydrogen phosphate solution; and mixing the potassium dihydrogen phosphate solution and the disodium hydrogen phosphate solution according to the volume ratio of 95:5, and continuously adjusting the volume ratio of the potassium dihydrogen phosphate solution to the disodium hydrogen phosphate solution until the pH value is 4.5 to obtain the phosphoric acid buffer solution.
The preparation method of the macroporous resin column comprises the following steps: soaking D101 resin in 2 times of anhydrous ethanol for 24h, washing with water of the same volume as that of D101 resin for several times, and loading into a phi 30mm x 500mm resin column to obtain the macroporous resin column.
The preparation method of the centella extract comprises the following steps: soaking herba Centellae in 4 times of water at 8 deg.C for 2 hr, extracting at 75 deg.C for 3 hr, and filtering with 100 mesh medicinal screen to obtain filtrate A and herba Centellae residue; adding water 6 times the mass of herba Centellae filter residue into the herba Centellae filter residue, extracting at 80 deg.C for 2 hr, filtering with 100 mesh medicinal filter net to obtain extractive solution B, mixing extractive solutions A and B, and concentrating in rotary evaporator at 60 deg.C and vacuum degree of 0.05MPa for 3.5 hr to obtain herba Centellae extract.
The preparation method of the rosemary leaf extract comprises the following steps: drying fresh rosemary leaves at 55 ℃ for 48h, crushing to 150 meshes to obtain rosemary leaf powder, adding 55 wt% ethanol aqueous solution which is 4 times of the mass of the rosemary leaf powder, performing supercritical extraction for 3h, wherein the extraction pressure is 20MPa, the extraction temperature is 40 ℃, the separation pressure is 5MPa, and the separation temperature is 35 ℃ to obtain supercritical extract and supercritical raffinate; adding 50 wt% methanol aqueous solution 20 times of the supercritical raffinate, and performing ultrasonic treatment at 55 deg.C for 20min with ultrasonic power of 350W and ultrasonic frequency of 30kHz to obtain ultrasonic extractive solution; and combining the supercritical extract and the ultrasonic extracting solution, filtering through 250-mesh filter cloth, putting the obtained filtrate into a rotary evaporator with the temperature of 60 ℃ and the vacuum degree of 0.05MPa, and concentrating until the residual volume is 5% of the original volume to obtain the rosemary leaf extract.
The preparation method of the pelargonium roseum extract comprises the following steps: drying pelargonium graveolens, then crushing to 60 meshes, adding 95W% ethanol water solution according to the mass volume ratio of 1:18(g/mL), performing ultrasonic extraction at 50 ℃ for 20min, wherein the ultrasonic power of ultrasonic treatment is 500W, the ultrasonic frequency is 40Hz, placing the obtained filtrate in a rotary evaporator with the temperature of 50 ℃ and the vacuum degree of 0.05MPa, and concentrating until the residual volume is 4% of the original volume to obtain the pelargonium graveolens extract.
The preparation method of the licorice extract comprises the following steps: cleaning and drying the licorice raw material, adding the licorice raw material into water according to the mass volume ratio of 1:10(g/mL) for decoction at 90 ℃ for 30min, and filtering the licorice raw material through 100-mesh filter cloth to obtain a first decoction and licorice filter residue; adding 10 times of water into Glycyrrhrizae radix residue, decocting at 95 deg.C for 30min to obtain second decoction, mixing the first and second decoctions, concentrating at 50 deg.C and 0.05MPa in a rotary evaporatorShrinking for 2h, and spray drying at air inlet temperature and air outlet temperature of 165 deg.C, 75 deg.C, and hot air speed of 4m3At a feed rate of 35mL/min, Glycyrrhiza extract was obtained.
The preparation method of the senecio cineraria extract comprises the following steps: adding chamomile into 70 wt% ethanol aqueous solution according to the mass-volume ratio of 1:12(g/mL), soaking at 30 ℃ for 2h, extracting at 75 ℃ for 2h, filtering through 100-mesh filter cloth, placing the obtained filtrate in a rotary evaporator with the temperature of 60 ℃ and the vacuum degree of 0.05MPa, and concentrating until the residual volume is 8% of the original volume to obtain the chamomile extract.
The preparation method of the peony root extract comprises the following steps: cleaning the peony root, naturally airing, crushing to 100 meshes to obtain peony root powder, adding 60 wt% acetone aqueous solution into the peony root powder, carrying out oscillatory leaching for 2 hours at 50 ℃ and 200r/min according to the mass-volume ratio of the peony root powder to the 60 wt% acetone aqueous solution of 1:8(g/mL), and filtering through 200 meshes of filter cloth to obtain filtrate C and peony root filter residue; adding 60 wt% ethanol water solution into the obtained peony root filter residue, wherein the mass volume ratio of the peony root filter residue to the 60 wt% ethanol water solution is 1:8(g/mL), carrying out shaking extraction for 2h at 50 ℃ and 200r/min, filtering through 200-mesh filter cloth to obtain a filtrate D, combining the filtrate C and the filtrate D, carrying out refrigerated centrifugation on the obtained mixed extracting solution at the temperature of-2 ℃ and the rotating speed of 15000r/m for 28min, placing the obtained supernatant into a rotary evaporation instrument at 55 ℃ and the vacuum degree of 0.05MPa, and carrying out rotary concentration until the residual volume is 4% of the original volume to obtain the peony root extract.
The preparation method of the honeysuckle flower extract comprises the following steps: adding honeysuckle flower into a 70 wt% ethanol aqueous solution, wherein the mass volume ratio of the honeysuckle flower to the 50 wt% ethanol aqueous solution is 1:8(g/mL), extracting at 85 ℃ for 2h, and filtering through 150-mesh filter cloth to obtain filtrate E and honeysuckle flower filter residue; adding 70 wt% ethanol water solution with the same volume as that of the first extraction into the honeysuckle flower filter residue, extracting at 85 ℃ for 2h, filtering through 150-mesh filter cloth to obtain filtrate F, combining the filtrate E and the filtrate F, and drying at 70 ℃ under the vacuum degree of 50Pa for 3.5h to obtain the honeysuckle flower extract.
The preparation method of the glycyrrhiza glabra root extract comprises the following steps: naturally airing the glycyrrhiza glabra roots, crushing the glycyrrhiza glabra roots into 50 meshes, adding a mixed extracting agent into the obtained glycyrrhiza glabra root powder according to the mass-volume ratio of 1:8(g/mL), carrying out ultrasonic extraction at 30 ℃ for 20min, carrying out ultrasonic treatment with the ultrasonic power of 250W and the ultrasonic frequency of 50Hz, carrying out suction filtration, adding the obtained solid into 70 wt% ethanol water solution, after complete dissolution, centrifuging at 10 ℃ at the rotating speed of 3000r/min for 15min, adding the obtained supernatant into a macroporous resin column with the sampling speed of 2BV/h, stopping after no liquid flows out, keeping the sampling speed unchanged, washing the column with distilled water with the volume 2 times of the volume of the supernatant, eluting with 65 wt% ethanol water solution with the volume 2 times of the volume of the supernatant, collecting the effluent of the ethanol elution water solution, and (3) carrying out vacuum freeze drying on the obtained ethanol water solution elution effluent under the conditions that the thickness of the material is controlled to be 8mm, the pre-freezing temperature is set to be-40 ℃, the sample is kept for 2 hours after the temperature is reduced to the set temperature, the sublimation temperature is set to be 10 ℃, the analysis temperature is 35 ℃, the vacuum degree is 30pa, and the material is dried for 24 hours to obtain the glycyrrhiza glabra root extract.
The preparation method of the giant knotweed root extract comprises the following steps: pulverizing rhizoma Polygoni Cuspidati to 40 mesh, weighing, adding 80 wt% ethanol water solution according to a material-to-liquid ratio of 1:4, extracting at 85 deg.C for 3h, filtering with 150 mesh filter cloth, and vacuum drying the filtrate at 70 deg.C under 50Pa for 2h to obtain rhizoma Polygoni Cuspidati extract.
The preparation method of the jackfruit peel extract comprises the following steps: peeling fresh jack fruit, cleaning the obtained peel, draining, drying at 55 deg.C until the water content is about 6%, pulverizing, and sieving with 60 mesh sieve to obtain jackfruit peel powder; adding 60 wt% of ethanol aqueous solution into the jack fruit peel powder according to the mass-to-volume ratio of 1:25(g/mL), carrying out ultrasonic treatment for 15min at 40 ℃, wherein the ultrasonic power of the ultrasonic treatment is 400W, the ultrasonic frequency is 40Hz, centrifuging for 20min at 6000r/min, taking supernatant, placing the supernatant into a rotary evaporator with the temperature of 50 ℃ and the vacuum degree of 0.05MPa, concentrating for 2h, carrying out vacuum freeze drying on the obtained concentrated solution, wherein the vacuum freeze drying condition is to control the material thickness to be 10mm, setting the pre-freezing temperature to be-40 ℃, keeping for 2h when the sample temperature is reduced to the set temperature, setting the sublimation temperature to be 10 ℃, the analysis temperature to be 35 ℃, the vacuum degree to be 30pa, and drying for 30h to obtain the jack fruit peel extract.
The preparation method of the tea extract comprises the following steps: cleaning and drying tea leaves, adding the tea leaves into 50 wt% ethanol water solution, wherein the mass volume ratio of the tea leaves to the 50 wt% ethanol water solution is 1: 9(g/mL), performing microwave treatment at 70 deg.C for 5min with power of 560W, filtering with 100 mesh filter cloth, placing the filtrate in rotary evaporator, concentrating at 50 deg.C and vacuum degree of 0.05MPa until the residual volume is 8% of the original volume to obtain folium Camelliae sinensis extract.
The preparation method of the scutellaria root extract comprises the following steps: pulverizing dried radix Scutellariae to 80 mesh, and mixing at a ratio of 1: adding 65 wt% methanol water solution into 10 of the raw materials, extracting at 80 deg.C for 3 hr, filtering with 200 mesh filter cloth to obtain filtrate and radix Scutellariae residue, concentrating at 50 deg.C and vacuum degree of 0.05MPa for 2 hr, and vacuum drying at 70 deg.C and 40Pa for 2 hr to obtain radix Scutellariae extract.
The ultrafiltration equipment is an SS-UR100-1812 type ultrafiltration membrane, has a molecular weight cut-off of 10 ten thousand and is purchased from Zhongke Ruiyang Membrane technology (Beijing) Co.
The microwave equipment is an LWMC-205 type power-adjustable microwave chemical reactor, and is purchased from Nanjing Lingjiang science and technology development, LLC.
The ultrasonic equipment is KQ-2500E type ultrasonic cleaner available from Kunshan Seama instruments Co., Ltd
Spray drying equipment, ZOLLO-6000Y spray dryer available from Shanghai Lele instruments Co.
The vacuum drying oven was a model DZF-6020 vacuum drying oven available from Shanghai Keliter instruments Co., Ltd.
The vacuum freeze-drying equipment is FD-100S type vacuum freeze-drying machine, which is purchased from Beijing Huicheng Jia apparatus science and technology Limited.
Example 1
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of skin conditioner, 3 wt% of whitening agent, 0.75 wt% of tea leaf extract, 0.75 wt% of scutellaria baicalensis root extract, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The whitening agent is prepared by mixing a glycyrrhiza glabra root extract and a polygonum cuspidatum root extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract is 1: 1.
the preparation method of the aloe extract comprises the following steps:
selecting aloe without diseases and spots on the surface, cleaning, airing, peeling, dicing the peeled aloe, and putting the diced aloe in hot water at 95 ℃ for deactivation of enzymes for 30 s;
drying the de-enzymed aloe at 55 deg.C for 10 hr, and pulverizing to 50 mesh to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and stirring for 30min at the temperature of 25 ℃ and the speed of 600r/min, wherein the mass-volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: 0.3: 15(g/g/ml), performing enzymolysis for 1.5h at 45 ℃, and filtering through 100-mesh filter cloth to obtain an enzymolysis solution;
IV, filtering the enzymatic hydrolysate by using an ultrafiltration membrane, wherein the molecular weight cut-off of the ultrafiltration membrane is 10 ten thousand, and performing ultrafiltration under the conditions of the driving pressure of 0.15MPa and the temperature of 25 ℃ to obtain ultrafiltrate;
spray drying the ultrafiltrate, wherein the inlet air temperature of the spray drying equipment is 165 ℃, the outlet air temperature is 80 ℃, and the hot air speed is 4m3Drying at a feed rate of 40mL/min for 1.5s to obtain aloe extract with water content of 4%.
The enzyme is prepared by mixing cellulase and protease according to the mass ratio of 1: 1.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent, a tea leaf extract and a scutellaria baicalensis root extract, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activation balancing conditioning essence liquid.
Example 2
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of skin conditioner, 3 wt% of whitening agent, 0.5 wt% of tocopherol, 0.5 wt% of tea leaf extract, 0.5 wt% of scutellaria baicalensis root extract, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The whitening agent is prepared by mixing a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract to the jackfruit peel extract is 1:1: 1.
the preparation method of the aloe extract comprises the following steps:
selecting aloe without diseases and spots on the surface, cleaning, airing, peeling, dicing the peeled aloe, and putting the diced aloe in hot water at 95 ℃ for deactivation of enzymes for 30 s;
drying the de-enzymed aloe at 55 deg.C for 10 hr, and pulverizing to 50 mesh to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and stirring for 30min at the temperature of 25 ℃ and the speed of 600r/min, wherein the mass-volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: 0.3: 15(g/g/ml), treating at 40 deg.C for 8min by microwave radiation with power of 560W, and filtering with 100 mesh filter cloth to obtain extractive solution a and aloe residue;
adding enzyme and phosphoric acid buffer solution into the aloe filter residue, and stirring for 30min at the temperature of 25 ℃ and the speed of 600r/min, wherein the mass-to-volume ratio of the aloe filter residue to the enzyme to the phosphoric acid buffer solution is 1: 0.3: 15(g/g/ml), then carrying out ultrasonic extraction for 15min at 50 ℃, wherein the ultrasonic power of ultrasonic treatment is 500W, the ultrasonic frequency is 40Hz, and filtering through 100-mesh filter cloth to obtain an extracting solution b;
combining the extracting solution a and the extracting solution b, and filtering the obtained mixed extracting solution by adopting an ultrafiltration membrane, wherein the molecular weight cut-off of the ultrafiltration membrane is 10 ten thousand, and ultrafiltration is carried out under the conditions of the driving pressure of 0.15MPa and the temperature of 25 ℃ to obtain ultrafiltrate;
VI, spray drying the ultrafiltrate, wherein the air inlet temperature of the spray drying equipment is 165 ℃, the air outlet temperature is 80 ℃, and the air speed of the hot air is 4m3Drying at a feed rate of 40mL/min for 1.5s to obtain aloe extract with water content of 4%.
The enzyme is prepared by mixing cellulase and protease according to the mass ratio of 1: 1.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent, tocopherol, a tea leaf extract and a scutellaria baicalensis root extract, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activity-endowing balanced conditioning essence disclosed by the invention.
Example 3
Essentially the same as example 2, except that: the preparation method of the aloe extract comprises the following steps:
selecting aloe without diseases and spots on the surface, cleaning, airing, peeling, dicing the peeled aloe, and putting the diced aloe in hot water at 95 ℃ for deactivation of enzymes for 30 s;
drying the de-enzymed aloe at 55 deg.C for 10 hr, and pulverizing to 50 mesh to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and stirring for 30min at the temperature of 25 ℃ and the speed of 600r/min, wherein the mass-volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: 0.3: 15(g/g/ml), performing enzymolysis for 1.5h at 45 ℃, and filtering through 100-mesh filter cloth to obtain an enzymolysis solution;
IV, filtering the enzymatic hydrolysate by using an ultrafiltration membrane, wherein the molecular weight cut-off of the ultrafiltration membrane is 10 ten thousand, and performing ultrafiltration under the conditions of the driving pressure of 0.15MPa and the temperature of 25 ℃ to obtain ultrafiltrate;
spray drying the ultrafiltrate, wherein the inlet air temperature of the spray drying equipment is 165 ℃, the outlet air temperature is 80 ℃, and the hot air speed is 4m3Drying at a feed rate of 40mL/min for 1.5s to obtain aloe extract with water content of 4%.
The enzyme is prepared by mixing cellulase and protease according to the mass ratio of 1: 1.
Example 4
Essentially the same as example 2, except that: the preparation method of the aloe extract comprises the following steps: the preparation method of the aloe extract comprises the following steps:
selecting aloe without diseases and spots on the surface, cleaning, airing, peeling, dicing the peeled aloe, and putting the diced aloe in hot water at 95 ℃ for deactivation of enzymes for 30 s;
drying the de-enzymed aloe at 55 deg.C for 10 hr, and pulverizing to 50 mesh to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and stirring for 30min at the temperature of 25 ℃ and the speed of 600r/min, wherein the mass-volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: 0.3: 15(g/g/ml), treating at 40 deg.C for 8min by microwave radiation with power of 560W, and filtering with 100 mesh filter cloth to obtain extractive solution;
IV, filtering the obtained extracting solution by adopting an ultrafiltration membrane, wherein the molecular weight cut-off of the ultrafiltration membrane is 10 ten thousand, and carrying out ultrafiltration under the conditions of the driving pressure of 0.15MPa and the temperature of 25 ℃ to obtain ultrafiltrate;
VI, spray drying the ultrafiltrate, wherein the air inlet temperature of the spray drying equipment is 165 ℃, the air outlet temperature is 80 ℃, and the air speed of the hot air is 4m3Drying at a feed rate of 40mL/min for 1.5s to obtain aloe extract with water content of 4%.
The enzyme is prepared by mixing cellulase and protease according to the mass ratio of 1: 1.
Example 5
Essentially the same as example 2, except that: the whitening agent is a glycyrrhiza glabra root extract and a polygonum cuspidatum root extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract is 1: 1.
example 6
Essentially the same as example 2, except that: the whitening agent is a giant knotweed root extract and a jackfruit peel extract, wherein the mass ratio of the giant knotweed root extract to the jackfruit peel extract is 1: 1.
example 7
Essentially the same as example 2, except that: the whitening agent is a glycyrrhiza glabra root extract and a jackfruit peel extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the jackfruit peel extract is 1: 1.
comparative example 1
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of skin conditioner, 0.5 wt% of tocopherol, 0.5 wt% of tea leaf extract, 0.5 wt% of scutellaria baicalensis root extract, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The aloe extract was prepared in the same manner as in example 2.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, tocopherol, a tea leaf extract and a scutellaria baicalensis root extract, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activation balancing conditioning essence liquid.
Example 8
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of a skin conditioner, 3 wt% of a whitening agent, 0.75 wt% of tocopherol, 0.75 wt% of a tea leaf extract, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The whitening agent is prepared by mixing a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract to the jackfruit peel extract is 1:1: 1.
the aloe extract was prepared in the same manner as in example 2.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent, tocopherol and a tea leaf extract, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activation balancing conditioning essence liquid.
Example 9
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of skin conditioner, 3 wt% of whitening agent, 0.75 wt% of tea leaf extract, 0.75 wt% of scutellaria baicalensis root extract, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The whitening agent is prepared by mixing a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract to the jackfruit peel extract is 1:1: 1.
the aloe extract was prepared in the same manner as in example 2.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent, a tea leaf extract and a scutellaria baicalensis root extract, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activation balancing conditioning essence liquid.
Example 10
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of a skin conditioner, 3 wt% of a whitening agent, 0.75 wt% of tocopherol, 0.75 wt% of scutellaria baicalensis root extract, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The whitening agent is prepared by mixing a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract to the jackfruit peel extract is 1:1: 1.
the aloe extract was prepared in the same manner as in example 2.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent, tocopherol and a scutellaria baicalensis root extract, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activation balancing conditioning essence disclosed by the invention.
Comparative example 2
The activity-promoting balance conditioning essence consists of the following raw materials in parts by weight: 10 wt% of butanediol, 7 wt% of propylene glycol, 3 wt% of trehalose, 0.8 wt% of hyaluronic acid, 0.5 wt% of centella asiatica extract, 0.3 wt% of rosemary leaf extract, 0.2 wt% of panthenol, 0.2 wt% of 1, 2-pentanediol, 0.03 wt% of geranium extract, 0.3 wt% of ethylhexyl glycerin, 8 wt% of a skin conditioner, 3 wt% of a whitening agent, and the balance of deionized water.
The skin conditioner is prepared from the following raw materials in parts by weight: 30 wt% of aloe extract, 10 wt% of licorice extract, 20 wt% of senecio cineraria extract, 15 wt% of peony root extract, 15 wt% of honeysuckle extract and 10 wt% of ceramide.
The whitening agent is prepared by mixing a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract, wherein the mass ratio of the glycyrrhiza glabra root extract to the polygonum cuspidatum root extract to the jackfruit peel extract is 1:1: 1.
the aloe extract was prepared in the same manner as in example 2.
The preparation method of the activation-balanced conditioning essence comprises the following steps:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, stirring at the temperature of 80 ℃ at the rotating speed of 700r/min for 20min, and uniformly mixing to obtain a mixture;
and III, cooling the mixture to 40 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner and a whitening agent, keeping the temperature unchanged, stirring at the rotating speed of 450r/min for 15min, cooling to 25 ℃, standing for 24h, and discharging to obtain the activation-balanced conditioning essence liquid.
Test example 1
Skin sensitivity test: 200 skin-sensitive subjects were screened by a lactic acid sting test, and divided into 10 groups of 20 subjects, each group was applied with the revitalizing balance conditioning essence obtained in examples 1 to 10, each group was applied with the revitalizing balance conditioning essence twice a day in the morning and evening on the facial skin, and the subjects were subjected to the lactic acid sting test after 0 day, 14 days, and 28 days of use of the product of the present invention.
Lactic acid sting test: preparing 50 mu L of 10 wt% lactic acid solution, dripping the lactic acid solution on a single-layer filter paper with the diameter of 0.8cm, placing the single-layer filter paper on the nasolabial sulcus of a subject, inquiring the stabbing pain feeling of the subject and observing the skin condition respectively for 3min, 4min and 5min, and grading according to a 4-point method, (0 is no stabbing pain, 1 is mild stabbing pain, 2 is moderate stabbing pain, 3 is severe stabbing pain) and the sum of the stabbing pain is more than or equal to 3, and the test result is shown in a table 1. Comparing the test results of each group, and obtaining that P is less than 0.05 by a statistical analysis method, which shows that the average difference of the samples has statistical significance.
Table 1: lactic acid stabbing pain evaluation table
| Sample (I) | 0d | 14d | 28d |
| Example 1 | 3.7 | 3.2 | 2.9 |
| Example 2 | 2.8 | 2.4 | 2.2 |
| Example 3 | 3.6 | 3.1 | 2.7 |
| Example 4 | 3.5 | 2.7 | 2.5 |
| Example 5 | 2.9 | 2.5 | 2.3 |
| Example 6 | 2.9 | 2.6 | 2.4 |
| Example 7 | 3.1 | 2.4 | 2.3 |
| Example 8 | 3.4 | 2.7 | 2.4 |
| Example 9 | 3.3 | 2.7 | 2.5 |
| Example 10 | 3.4 | 2.6 | 2.4 |
The experimental data in the comparison table show that the activation-balanced conditioning essence disclosed by the invention improves the tolerance of skin by adding a plurality of plant components, and has a good anti-allergy effect.
Test example 2
Skin barrier repair performance test: the skin barrier function is one of the important physiological functions of the skin, and the skin function has important relation with the health of the skin, the selection of skin care and beauty and the using effect, and mainly refers to the permeation function of the skin to physical, chemical, biological, moisture and the like, and the permeation function is mainly expressed on the epidermis, particularly on the stratum corneum. The barrier function is poor, and skin moisture is easy to lose, so that the skin is dry; the shielding effect is too strong, the absorption is not good when a plurality of nutrient substances are used, and the effect can not be achieved. According to the method of 1.2 in Zhu-Shing 'inspection of skin barrier function of adult female face in Kunming area', 180 patients with acne vulgaris are selected as volunteers, half of men and women are randomly divided into 9 groups, the activation balance conditioning essence in the examples 2-10 is respectively used, the circulation is performed once in the morning and at night, after 28 days, the change conditions of the physiological functions of the skin before and after use are observed by measuring the sebum content in the middle of the forehead and the value of percutaneous water loss (TEWL), wherein the TEWL indicates the condition of water loss by measuring the water vapor pressure gradient on the surface of the skin, and the value reflects the water permeability barrier of the skin. The specific test results are shown in table 2. Comparing the test results of each group, and obtaining that P is less than 0.05 by a statistical analysis method, which shows that the average difference of the samples has statistical significance.
Table 1: skin barrier repair performance test result table
From the test data of the examples 2 to 4 in the table 2, it can be seen that the physiological functions of the volunteers who activated the balanced conditioning essence of the example 2 before and after use are obviously lower in sebum content and trans-epidermal water loss than those of the volunteers of the examples 3 to 4, which indicates that the activated balanced conditioning essence of the example 2 is better than those of the examples 3 to 4 in the aspects of improving the cortex content and trans-epidermal water loss.
Test example 3
And (3) testing the whitening effect: solutions of the activation-providing balanced conditioning essence of examples 2 to 10 and comparative example 1 at a concentration of 0.2mg/mL were prepared using 0.2mol/L Phosphate Buffered Saline (PBS) having a pH of 6.8 as a solvent.
0.9mL of the activation-providing balanced conditioning essence prepared in the above example was taken, and a prepared solution having a concentration of 0.2mg/mL was added with 1mL of L-tyrosine (0.3mol) and 1mL of Phosphate Buffered Saline (PBS) having a pH of 6.8, preheated in a constant temperature water bath at 35 ℃ for 10min, and then 0.1mL of an aqueous tyrosinase solution (1.0mg/mL, Mclvains buffer) was added thereto, sufficiently stirred, reacted at 35 ℃ for 15min, and then absorbance at 475nm was measured (D1). In addition, the same reaction was carried out using the phosphate buffer solution in place of the 0.2mg/mL solution prepared in examples 1 to 7, and the absorbance was measured (D2). For control, absorbance was measured without addition of the sample solution and tyrosinase (D3). The tyrosinase activity inhibition rate was calculated by the following formula:
tyrosinase activity inhibition rate (%) (D2-D1)/(D2-D3) × 100
The results are shown in Table 3:
table 3: tyrosinase activity inhibition rate test result table
| Time | Inhibition of tyrosinase activity/%) |
| Example 2 | 89.5 |
| Example 3 | 82.3 |
| Example 4 | 85.2 |
| Example 5 | 76.9 |
| Example 6 | 77.4 |
| Example 7 | 76.1 |
| Example 8 | 86.8 |
| Example 9 | 87.1 |
| Example 10 | 87.4 |
| Comparative example 1 | 71.5 |
Comparing example 2 with examples 5-7 and comparative example 1, the tyrosinase activity inhibition rate of example 2 (the whitening agent is prepared by compounding any two of glycyrrhiza glabra root extract, polygonum cuspidatum root extract and jackfruit peel extract) is obviously better than that of examples 5-7 (the whitening agent is prepared by compounding any two of glycyrrhiza glabra root extract, polygonum cuspidatum root extract and jackfruit peel extract) and comparative example 1 (the whitening agent is not added).
Test example 4
Skin elasticity test: the wrinkle-removing performance of the revitalizing and balancing conditioning essence in examples 2 to 10 and comparative example 2 was evaluated, and skin elasticity was used as a test index.
Test subjects: a total of 180 subjects aged 35 years, females, were selected and randomized into 9 groups of 20 subjects each. The subjects were free of serious systemic disease, no active allergic disease, and had not been tested for skin treatment, cosmetic, and other possible effects. The test site of the subject was unable to use any cosmetic or topical drug 3 days prior to testing.
The test method comprises the following steps: before applying the cosmetic, the subject washed their face with a conventional facial cleanser, and then selected 5X 5cm at the left side of the subject's face2The square area of the size is used as a test area, about 0.5g of the activation balance conditioning essence is smeared, the activation balance conditioning essence is used once in the morning and at night, and the activation balance conditioning essence is used every day to avoid outdoor solarization. In makingBefore the cosmetic of the present invention was applied, the elasticity value of the test area was measured with a skin elasticity tester (supplied by CK company, germany, model number MPA 580); the elasticity values of the test areas were again measured after 4 weeks of application. 5 elastic R measurements per test area2And the average value is taken.
The skin elasticity is measured by a suction method in a constant negative pressure mode, namely a test probe applies negative pressure on the skin surface to suck the skin into a probe hole, the skin deformation recovers after the negative pressure disappears, the skin deformation can be measured along with the negative pressure and time change by a device which emits light and receives light in a tester, the device can reflect the sucked depth of the skin, thus a graph of the skin stretching length along with the time change can be obtained, Uf represents the maximum stretching amount of the skin, Ue represents the stretching amount of the skin when the constant negative pressure is applied to the skin for 0.1 second, Ur represents the skin recovery amount after no negative pressure is applied for 0.1S, Uv is the viscous elastic part of Uf-Ue, Ua represents the recovery amount of the skin after the negative pressure is cancelled and the negative pressure is added in the next continuous test, and R represents the recovery amount of2＝Ua/Uf，R2Is a parameter reflecting the elasticity of the skin, R2The larger the value the better the skin elasticity, the closer to 1 the elasticity.
Comparing the test results of each group, and obtaining that P is less than 0.05 by a statistical analysis method, which shows that the average difference of the samples has statistical significance. The specific test results are shown in table 4.
Table 4: skin elasticity test data sheet
As can be seen from table 4, comparing examples 2, 8-10 and comparative example 2, it can be seen that the anti-wrinkle effect of the active balance conditioning essence in example 2 using the antioxidant comprising tocopherol, tea extract and scutellaria root extract is better than that of the active balance conditioning essence in examples 8-10 (the antioxidant comprising any two of tocopherol, tea extract and scutellaria root extract) and comparative example 2 without antioxidant, so that the anti-wrinkle effect of the active balance conditioning essence is enhanced by adding the antioxidant.
The foregoing is considered as illustrative and not restrictive in character, and that all equivalent and simple variations on the principles taught herein are included within the scope of the present invention; various modifications, additions and substitutions for the specific embodiments described may be made by those skilled in the art without departing from the scope of the invention as defined in the accompanying claims.
Claims (5)
1. The revitalizing and balancing conditioning essence is characterized by comprising the following raw materials in parts by weight: 9-13 wt% of butanediol, 3-10 wt% of propylene glycol, 2-4 wt% of trehalose, 0.2-1 wt% of hyaluronic acid, 0.05-1 wt% of centella asiatica extract, 0.1-0.5 wt% of rosemary leaf extract, 0.05-0.5 wt% of panthenol, 0.05-0.4 wt% of 1, 2-pentanediol, 0.01-0.05 wt% of geranium extract, 0.1-0.5 wt% of ethylhexylglycerin, 4-12 wt% of a skin conditioner, 2-5 wt% of a whitening agent, 0.5-3 wt% of an antioxidant and the balance of water;
the skin conditioner is prepared from the following raw materials in parts by weight: 20-32 wt% of aloe extract, 10-15 wt% of licorice extract, 20-25 wt% of senecio cineraria extract, 10-20 wt% of peony root extract, 15-21 wt% of honeysuckle extract and 2-10 wt% of ceramide;
the preparation method of the aloe extract comprises the following steps:
cleaning, airing, peeling and dicing aloe, and putting the aloe into hot water at 90-100 ℃ for fixation to obtain the aloe after fixation;
II, draining, drying and crushing the de-enzymed aloe to obtain aloe powder;
adding enzyme and phosphoric acid buffer solution into the aloe powder, and uniformly mixing, wherein the mass volume ratio of the aloe powder to the enzyme to the phosphoric acid buffer solution is 1: (0.05-0.5): (10-15) (g/g/ml), extracting by microwave radiation, and filtering to obtain an extracting solution a and aloe filter residue;
and IV, adding the aloe filter residue into an enzyme and phosphoric acid buffer solution, and uniformly mixing, wherein the mass volume ratio of the aloe filter residue to the enzyme to the phosphoric acid buffer solution is 1: (0.05-0.5): (10-15) (g/g/ml), extracting by ultrasonic, and filtering to obtain an extracting solution b;
mixing the extracting solution a and the extracting solution b, and performing ultrafiltration on the obtained mixed extracting solution to obtain ultrafiltrate;
VI, drying the ultrafiltrate by a spray drying method to obtain the aloe extract
The whitening agent is prepared from a glycyrrhiza glabra root extract, a polygonum cuspidatum root extract and a jackfruit peel extract according to the mass ratio of (1-5): (1-5): (1-5).
2. The vital balancing conditioning essence of claim 1, wherein the antioxidant is one or more of tocopherol, tea extract, and scutellaria root extract.
3. The active balance conditioning essence of claim 1 wherein the ceramide is one or more of ceramide 1, ceramide 2 and ceramide 6 II.
4. The vital conditioning serum of claim 1 wherein the enzyme is a cellulase or/and a protease; the pH value of the phosphoric acid buffer solution ranges from 4 to 6.
5. A method of preparing the active balance conditioning serum as claimed in claim 1, comprising the steps of:
weighing raw material components in parts by weight;
II, mixing water, butanediol, propylene glycol, trehalose, hyaluronic acid, panthenol, 1, 2-pentanediol and ethylhexylglycerin, and uniformly stirring at 65-85 ℃ to obtain a mixture;
and III, cooling the mixture to 35-50 ℃, adding a centella asiatica extract, a rosemary leaf extract, a geranium extract, a skin conditioner, a whitening agent and an antioxidant, uniformly stirring, cooling to 25-35 ℃, standing for 18-35h, and discharging to obtain the activity-activating balance conditioning essence disclosed by the invention.
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| CN112641685A (en) * | 2019-10-10 | 2021-04-13 | 广州樱奈儿化妆品有限公司 | Moisturizing and circulation promoting essence and preparation method thereof |
| CN110693796A (en) * | 2019-11-20 | 2020-01-17 | 星皇亚太企业（博罗）化工有限公司 | Oxygen injection essence and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550101A (en) * | 2013-11-06 | 2014-02-05 | 广州爱韵生物科技有限公司 | Plant extract with whitening and moisturizing functions and application thereof |
| CN104173232A (en) * | 2014-08-06 | 2014-12-03 | 金玲 | Method for preparing beautifying fluid capable of promoting skin resistance and repairing small-invasive skin |
| CN105769633A (en) * | 2014-12-18 | 2016-07-20 | 广东金奇精化股份有限公司 | Plant anti-allergy skincare essence and preparation method thereof |
| CN106309246A (en) * | 2016-10-10 | 2017-01-11 | 大连苗谣青颜生物科技有限公司 | Multieffect skin-smoothing cream and preparation method thereof |
| CN106389161A (en) * | 2016-09-29 | 2017-02-15 | 防城港市港口区高创信息技术有限公司 | Preparation method of cosmetic component with moisturizing efficacy |
| RU2650808C1 (en) * | 2016-12-09 | 2018-04-17 | Федеральное государственное бюджетное учреждение науки Мурманский морской биологический институт Кольского научного центра Российской академии наук (ММБИ КНЦ РАН) | Dry extract from fucus algae with antioxidant action and the method of its production |
-
2018
- 2018-05-07 CN CN201810426253.3A patent/CN108309873B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550101A (en) * | 2013-11-06 | 2014-02-05 | 广州爱韵生物科技有限公司 | Plant extract with whitening and moisturizing functions and application thereof |
| CN104173232A (en) * | 2014-08-06 | 2014-12-03 | 金玲 | Method for preparing beautifying fluid capable of promoting skin resistance and repairing small-invasive skin |
| CN105769633A (en) * | 2014-12-18 | 2016-07-20 | 广东金奇精化股份有限公司 | Plant anti-allergy skincare essence and preparation method thereof |
| CN106389161A (en) * | 2016-09-29 | 2017-02-15 | 防城港市港口区高创信息技术有限公司 | Preparation method of cosmetic component with moisturizing efficacy |
| CN106309246A (en) * | 2016-10-10 | 2017-01-11 | 大连苗谣青颜生物科技有限公司 | Multieffect skin-smoothing cream and preparation method thereof |
| RU2650808C1 (en) * | 2016-12-09 | 2018-04-17 | Федеральное государственное бюджетное учреждение науки Мурманский морской биологический институт Кольского научного центра Российской академии наук (ММБИ КНЦ РАН) | Dry extract from fucus algae with antioxidant action and the method of its production |
Non-Patent Citations (2)
| Title |
|---|
| 芦荟中多糖成分的提取、分离纯化及生物活性研究进展;刘洁等;《中国食物与营养》;20111231;第38-40页 * |
| 菠萝蜜果皮多酚提取工艺及其抗氧化和酪氨酸酶抑制作用研究;张祎敬;《食品科技》;20180131;第43卷(第1期);第215-221页 * |
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