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CN105165832B - Application of the succinate dehydrogenase inhibitors in control Sclerotinia fungi - Google Patents

Application of the succinate dehydrogenase inhibitors in control Sclerotinia fungi Download PDF

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Publication number
CN105165832B
CN105165832B CN201510459602.8A CN201510459602A CN105165832B CN 105165832 B CN105165832 B CN 105165832B CN 201510459602 A CN201510459602 A CN 201510459602A CN 105165832 B CN105165832 B CN 105165832B
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plant
seed
succinate dehydrogenase
dehydrogenase inhibitors
fungi
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CN105165832A (en
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英格·维施乐斯基
海客·瑞克
吉尔伯特·拉布尔代特
约瑟·奥古斯托·杰拉尔德斯
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Bayer Intellectual Property GmbH
Bayer CropScience AG
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
    • A01N37/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to succinate dehydrogenase inhibitors, especially fluopyram, application in control Sclerotinia fungi, further relate to the method for control Sclerotinia fungal biodegradation plant or plant parts, the method for further relating to neutralize the Sclerotinia fungal biodegradation seed in the plant grown up to by seed for control seed, wherein the seed is handled through succinate dehydrogenase inhibitors.

Description

Application of the succinate dehydrogenase inhibitors in control Sclerotinia fungi
It is on May 26th, 2010 that the application, which is the applying date, application No. is 201080024517.4, entitled " amber The divisional application of the application for a patent for invention of application of the dehydrogenase inhibitor in control Sclerotinia fungi ".
Technical field
The present invention relates to succinate dehydrogenase inhibitors especially fluopyrams (fluopyram), in control sclerotinite Belong to the application in fungi (Sclerotinia ssp.), further relates to processing plant or plant parts to control Sclerotinia fungi Method is further related to by handling seed with succinate dehydrogenase inhibitors, and control seed neutralizes in the plant grown up to by seed The method of Sclerotinia fungi.
Background technique
Sclerotinia fungi (Sclerotinia ssp.), especially sclerotinite (Sclerotinia sclerotiorum) Sclerotium size be 5-20mm, it is even more big in some cases.By sclerotium fungi can in the soil, infected plant residue Or it survives on perennial weeds.If moist condition takes several weeks, sclerotinite could be formed with sexual generation (sexual Stage): by the apothecium with ascospore of one to several centimetres sizes of sclerotium development.In the sclerotial germination phase, temperature is necessary Between 6 DEG C and about 15 DEG C.The concealment of sclerotium and wetland are the optimum conditions sprouted.Ascospore is finally released, And may cause the infection of leaf and stem, on condition that they infect weak plant tissue or wound.It falls into leaf fork and side shoot withers and falls Flower fair promote spore field planting, and finally make its sprouting.The optimum temperature of fungi growth is about 20 DEG C, but it still can be at 0 DEG C Growth.Sclerotium can be survived in the soil up to 10 years.
One mark outstanding is to make plant yellowing, and plant also becomes rapidly precocious.It, can be in master in such plant Observe entire stem by the discoloration of grey to brown in the lower part of branch.The inside of these stem color change portions be usually it is hollow, white, Cottony fungal mycelium proliferation is throughout wherein.The little particle sclerotium of black is formed in mycelium.Air humidity it is high or In the weather of constant humid, the mycelium and sclerotium occurred on plant is also formed in the external of stem.
In addition to rape, sclerotinite to sunflower, semen viciae fabae (broad bean), soybean, pea and clover and it is a variety of not Also there is great economic significance with vegetable crop.Weeds are also affected.
Sclerotinite occurs nearly in all herbaceous crops plants of tierra templada, is that most serious is endangered in soybean culture One of pathogen.
Therefore, there is an urgent need to be enough to control crop plants, such as rape, sunflower, semen viciae fabae, soybean, pea, clover by people With the fungicide of the Sclerotinia fungi especially sclerotinite in a variety of different vegetable crops.Core more preferably in control soybean Cup fungi.
WO 03/010149 discloses the formamide of Formulas I in control genetically modified plants such as soybean, rape (the 44-46 pages) In fungi such as sclerotinite (Sclerotinia sclerotiorum) (the 1st row of page 31) in application.According to the present invention, All plant, plant parts and/or propagation materials are through handling.It is disclosed at the 36-42 pages and mixes above-mentioned formamide again Match, as a series of fungicides.However, which specific formamide can not be obviously obtained from the introduction of the publication It is suitble to processing Sclerotinia fungi.
WO 2006/015865 discloses the mixture including succinate dehydrogenase inhibitors, such as cyclopamine (sedaxan) and the reactive compound (claim 1-10) of other anti-Sclerotinia fungies (the 7th row of page 59), for handling Grass, soybean, rape, sunflower, beans (page 58, the 4th row).The 51-52 pages discloses genetically modified plants and its processing.So And which specific formamide can not be obviously obtained from the introduction of the publication and is suitble to handle Sclerotinia fungi.More Specifically, the stability of cyclopamine processing Sclerotinia fungi is not disclosed clearly.
EP-A-1 389 614 discloses pyridine ethyl benzamide (pyridinilethylbenzamide) fungicide Derivative, such as fluopyram (claim 1-15) is used to prevent and treat on such as bean plant (the 4th row of page 6) Nuclear disk mushroom fungi (the 38-39 row of page 6).However, it is specific which can not obviously be obtained from the introduction of the publication Pyridine ethyl benzamide fungicide be suitble to handle Sclerotinia fungi.More specifically, not disclosing fluorine pyrrole bacterium acyl clearly The stability of amine processing Sclerotinia fungi.
WO 2007/1017231 disclose the formamide (claim 1-32) of Formulas I plant such as soybean, rape and to In day certain herbaceous plants with big flowers (the 27-30 row of page 16), the application of fungi such as sclerotinite is prevented and treated for seed treatment.It is disclosed in claim 8 Above-mentioned formamide is mixed and is compounded, as a series of fungicides.However, can not be apparent from the introduction of the publication Show that the formamide of which specific Formulas I is suitble to handle Sclerotinia fungi.
WO 2006/131221 discloses the formamide such as succinate dehydrogenase inhibitors Boscalid of Formulas I (boscalid) and pyrrole metsulfovax (penthiopyrad) (claim 4) is used to control the rust-fungi in bean plant, such as Sclerotinite (the 29th row of page 28 to the 12nd row of page 29).The genetically modified plants that can be handled, such as bean plant, equally It is disclosed (the 2nd section, page 37, claim 6).At the 2nd section, page 36 discloses seed treatment.The 31-32 pages disclose by A series of above-mentioned formamide mixing compounding, as fungicides.However, can not obviously be obtained from the introduction of the publication The formamide of which specific Formulas I is suitble to handle Sclerotinia fungi.More specifically, not disclosing Boscalid or pyrrole thiophene clearly The stability of bacterium amine processing Sclerotinia fungi.
WO 2007/118069 discloses a kind of active formamide (such as isopyrazam (isopyrazam)) by Formulas I The method of processing grass or grass seed prevention and treatment fungi such as Sclerotinia fungi (claim 11-15).The 19-20 pages disclose by A series of above-mentioned formamide mixing compounding, as fungicides.However, can not obviously be obtained from the introduction of the publication The formamide of whichever specific Formulas I is suitble to handle Sclerotinia fungi.
JP 2008/133237 discloses a kind of by pyrazole carboxamides, such as pyrrole metsulfovax (penthiopyrad) [0001], method of the soil treatment to prevent and treat sclerotinite class fungi [0007] is carried out for plant such as beans.
Summary of the invention
It has surprisingly been found that being selected from fluopyram, isopyrazam (isopyrazam), Boscalid (boscalid), N- [2- (1,3- dimethylbutyl) phenyl] the fluoro- 1,3- dimethyl -1H- pyrazole-4-carboxamide of -5-, cyclopropyl pyrrole Bacterium amine (sedaxan), N- (3', 4'- dichlorophenyl -2- base) -3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide, N- (2', 4'- dichlorophenyl -2- base) -3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide, 3- (difluoromethyl) - N- [2- (1,1,2,3,3,3- hexafluoro propoxyl group) phenyl] -1- methyl-1 H- pyrazole-4-carboxamide, 3- (difluoromethyl) -1- first Base-N- [2- (1,1,2,2- tetrafluoro ethyoxyl) phenyl] -1H- pyrazole-4-carboxamide, 3- (difluoromethyl) -1- methyl-N- (3', 4', 5'- trifluoro diphenyl -2- base) -1H- pyrazole-4-carboxamide, N- [2- (2,4 dichloro benzene base) -2- methoxyl group -1- methyl second Base] -3- difluoromethyl -1- methyl-1 H- pyrazole-4-carboxamide, flutolanil (flutolanil) and biphenyl pyrrole bacterium amine (bixafen), especially succinate dehydrogenase inhibitors of fluopyram are very suitable in control crop plants, such as oil Sclerotinia fungi in dish, sunflower, semen viciae fabae, soybean, pea, clover and vegetable crop, especially soybean, especially nuclear disk Bacterium.
Specific embodiment
However, the above-mentioned merely illustrative example of plant.In principle, it can handle with succinate dehydrogenase inhibitors by sclerotinite Belong to any plant of fungal infection.
It has been found that it is particularly advantageous to be used to control the sclerotinite in soybean for fluopyram.
In embodiment of the invention optional, including prothioconazoles (prothioconazole) and it is selected from Fluoxastrobin (azoxystrobin), ZEN 90160 (picoxystrobin), pyraclostrobin (pyraclostrobin), iprodione (iprodione), fludioxonil (fludioxonyl), propiconazole (propiconazole), epoxiconazole (epoxiconazole), Cyproconazole (cyproconazole), Tebuconazole (tebuconazole), procymidone (procimidone) (come from Sumitomo (Sumitomo) Sialex), fluazinam (fluazinam), carbendazim (carbendazim), SSF 126 (metaminostrobin) combination of other fungicides can be used for controlling the sclerotinite in soybean.
It is highly preferred that the combination of prothioconazoles and trifloxystrobin (trifloxystrobin) is suitable for controlling the core soybean Cup fungi.
Therefore the present invention provides succinate dehydrogenase inhibitors, especially fluopyram, answering in control sclerotinite With.
In the context of the present invention, succinate dehydrogenase inhibitors are in mitochondrial respiratory chain to succinate dehydrogenase Inhibited all active constituents.In a preferred embodiment of the present invention, succinate dehydrogenase inhibitors are selected from fluorine Pyrrole bacterium amide, isopyrazam, Boscalid, pyrrole metsulfovax, N- [2- (1,3- dimethylbutyl) phenyl] fluoro- 1,3- bis- of -5- Methyl-1 H- pyrazole-4-carboxamide, cyclopamine, N- (3', 4'- dichlorophenyl -2- base) -3- (difluoromethyl) -1- first Base -1H- pyrazole-4-carboxamide, N- (2', 4'- dichlorophenyl -2- base) -3- (difluoromethyl) -1- methyl-1 H- pyrazoles -4- Formamide, 3- (difluoromethyl)-N- [2- (1,1,2,3,3,3- hexafluoro propoxyl group) phenyl] -1- methyl-1 H- pyrazoles -4- formyl Amine, 3- (difluoromethyl) -1- methyl-N- [2- (1,1,2,2- tetrafluoro ethyoxyl) phenyl] -1H- pyrazole-4-carboxamide, 3- (two Methyl fluoride) -1- methyl-N- (3', 4', 5'- trifluoro diphenyl -2- base) -1H- pyrazole-4-carboxamide, N- [2- (2,4 dichloro benzene Base) -2- methoxyl group -1- Methylethyl] -3- difluoromethyl -1- methyl-1 H- pyrazole-4-carboxamide, flutolanil and biphenyl pyrrole bacterium The mixture of amine and these compounds.In especially preferred embodiment of the present invention, the succinate dehydrogenase inhibitors For fluopyram.
It is N- { [3- chloro- 5- (trifluoromethyl) -2- pyridyl group]-ethyl }-that EP-A-1 389 614, which describes chemical name, The fluopyram of 2,6- dichloro-benzamides, and its proper method prepared by commercially available starting material.
It is N- (the fluoro- 1,1'- diphenyl -2- base of the chloro- 5- of 3', 4'- bis-) -3- that WO 03/070705, which describes chemical name, The biphenyl pyrrole bacterium amine of (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide, and its fitted by prepared by commercially available starting material Work as preparation method.
WO 03/010149 describes N- [2- (1,3- dimethylbutyl) phenyl] fluoro- 1,3- dimethyl -1H- pyrazoles-of -5- Proper method 4- formamide (penflufen-containing, penflufen) and its prepared by commercially available starting material.
Cyclopamine be include 2 '-[(1RS, 2RS) -1,1 '-two cyclopropyl -2- base] -3- (difluoromethyl) -1- methyl pyrroles Two cis-isomers of azoles -4- formailide and 2 '-[(1RS, 2SR) -1,1 '-two cyclopropyl -2- base] -3- (difluoromethyl) - The mixture of two transisomers of 1- methylpyrazole -4- formailide.WO 03/074491, WO 2006/015865 and WO 2006/015866 proper method for describing cyclopamine and its being prepared by commercially available starting material.
Isopyrazam be include 3- (difluoromethyl) -1- methyl-N- [(1RS, 4SR, 9RS) -1,2,3,4- tetrahydro -9- Isopropyl -1,4- methanonaphthalene (methanonaphthalen) -5- base] pyrazole-4-carboxamide two same formula (syn) isomeries Body and 3- (difluoromethyl) -1- methyl-N- [(1RS, 4SR, 9SR) -1,2,3,4- tetrahydro -9- isopropyl -1,4- methanonaphthalene - 5- yl] pyrazole-4-carboxamide two transisomers mixture.WO 2004/035589 describe isopyrazam and its The proper method prepared by commercially available starting material.
It is (RS)-N- [2- (1,3- dimethylbutyl) -3- thienyl] -1- that EP-A-0 737 682, which describes chemical name, The pyrrole metsulfovax of methyl -3- (trifluoromethyl) pyrazole-4-carboxamide and its appropriate preparation prepared by commercially available starting material Method.
DE-A 195 31 813 describes the pyridine acyl that chemical name is the chloro- N- of 2- (4 '-chlorodiphenyl base -2- base) niacinamide Bacterium amine and its proper method prepared by commercially available starting material.
N- [2- (2,4 dichloro benzene base) -2- methoxyl group -1- Methylethyl] -3- difluoromethyl -1- methyl-1 H- pyrazoles -4- Formamide is the mixture of 4 stereoisomers.WO 2008/148570 describes what it was prepared by commercially available starting material Proper method.Stereoisomer N- [(1R, 2S) -2- (2,4 dichloro benzene base) -2- methoxyl group -1- Methylethyl]-(+) -3- two Methyl fluoride -1- methyl-1 H- pyrazole-4-carboxamide, N- [(1S, 2R) -2- (2,4 dichloro benzene base) -2- methoxyl group -1- methyl second Base]-(-) -3- difluoromethyl -1- methyl-1 H- pyrazole-4-carboxamide；N- [(1R, 2R) -2- (2,4 dichloro benzene base) -2- methoxy Base -1- Methylethyl]-(-) -3- difluoromethyl -1- methyl-1 H- pyrazole-4-carboxamide and N- [(1S, 2S) -2- (2,4- dichloro Phenyl) -2- methoxyl group -1- Methylethyl]-(+) -3- difluoromethyl -1- methyl-1 H- pyrazole-4-carboxamide can pass through HPLC It is separated from each other using chiral stationary phase, as described in WO 2010/000612.
WO 2005/123690 describes N- (3', 4'- dichlorophenyl -2- base) -3- (difluoromethyl) -1- methyl-1 H- Pyrazole-4-carboxamide, N- (2', 4'- dichlorophenyl -2- base) -3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide, 3- (difluoromethyl)-N- [2- (1,1,2,3,3,3- hexafluoro propoxyl group) phenyl] -1- methyl-1 H- pyrazole-4-carboxamide, 3- (two Methyl fluoride) -1- methyl-N- [2- (1,1,2,2- tetrafluoro ethyoxyl) phenyl] -1H- pyrazole-4-carboxamide, 3- (difluoromethyl) - 1- methyl-N- (3', 4', 5'- trifluoro diphenyl -2- base) -1H- pyrazole-4-carboxamide (fluorobenzene pyrrole bacterium amine, fluxapyroxad) And its proper method prepared by commercially available starting material.
In context of the invention, " control Sclerotinia fungi " refers to compared with untreated plant, can significantly drop The infection of low Sclerotinia fungi significantly reduces preferably compared with untreated plant (100%) and (reduces 40-79%)；More Preferably, the infection of Sclerotinia fungi is thoroughly inhibited and (inhibits 70-100%).The control can be therapeutic, that is, be used for The plant that has infected or protective is handled, for protecting not yet infected plant.
It is highly preferred that by spraying application, seed treatment, trickle irrigation and spray applications, chemigation, i.e., by by activity at Divide and be added in irrigation water and water planting/mineral system, application of the invention shows plant and plant parts or seed Advantage.
In context of the invention, succinate dehydrogenase inhibitors appropriate, preferably fluopyram, with include desinsection Agent, fungicide and bactericide, fertilizer, growth regulator substance combination, can be equally used for control plant disease.Separately Outside equally can be by succinate dehydrogenase inhibitors appropriate, preferably fluopyram, cultivar with improvement of genes, especially It is genetically engineered soybean cultivar connected applications.
In the context of the present invention, plant be preferably interpreted as leaf developmental stage or development after plant (according to German federal agriculture and forestry biological study center, second edition, 2001, BBCH monographs (BBCH monograph from the German Federal Biological Research Centre for Agriculture and Forestry,2nd edition, 2001), for 10 phase of BBCH or later).In the context of the present invention, term " plant " is it can be appreciated that seed or seedling.
It in one embodiment, for example, can be by succinate dehydrogenase inhibitors proposed by the present invention, preferably fluorine pyrrole bacterium Amide sprays and is applied to plant to be processed appropriate or plant parts.
The application of the preferred fluopyram of succinate dehydrogenase inhibitors proposed by the present invention, preferred dose is in 0.01- 3kg/ha particularly preferably works in 0.1-1kg/ha more preferably in 0.05-2kg/ha.
According to its specific physically and/or chemically property, succinate dehydrogenase inhibitors, preferably fluopyram, according to The present invention can be converted into conventional formulation, as solution, lotion, suspension, powder, foaming agent, paste, granule, aerosol and The micropackaging agent of polymer substance and coating material for seed and ULV changes in temperature atomization preparation.
These preparations can be prepared by known way, such as active constituent is mixed with filler, i.e., liquid solvent, subtract The liquefied gas and/or solid carrier of pressure optionally employ surfactant, i.e. emulsifier and/or dispersing agent and/or foaming agent. If the filler used is water, such as organic solvent also can be used as secondary solvent.Useful liquid solvent is substantially are as follows: Aromatic hydrocarbons such as dimethylbenzene, toluene or alkylnaphthalene, chlorinated aromatic hydrocarbons or chlorinated aliphatic hydrocarbon such as chlorobenzene, vinyl chloride or methylene chloride, aliphatic hydrocarbon Such as hexamethylene or paraffin, such as mineral oil fractions, alcohols such as butanol or glycol and its ethers and esters, ketone such as acetone, methyl Ethyl ketone, methyl iso-butyl ketone (MIBK) or cyclohexanone, intensive polar solvent such as dimethylformamide or dimethyl sulfoxide, Huo Zheshui.Liquefied gas It is gaseous liquid, such as aerosol propellant under normal temperature and normal pressure that body filler or carrier, which are interpreted as those, Such as halogenated hydrocarbons or butane, propane, nitrogen and carbon dioxide.Useful solid carrier are as follows: such as natural rock mountain flour, such as kaolinite Soil, clay, talcum, chalk, quartz, attapulgite, montmorillonite or diatomite, and the Rock Powder of synthesis, such as fine grinding dioxy SiClx, aluminium oxide and silicate.Useful solid carrier in granule: such as crushing the and point different day (fractionated) Right rock, such as calcite, float stone, marble, sepiolite, dolomite, and the inorganic and organic powdered granule of synthesis and organic Material grains, such as sawdust, cocoanut shell, maize cob and tabacco straw.Useful emulsifier and/or foam concentrate are as follows: such as Nonionic and anion emulsifier, such as polyoxyethanyl alkene fatty acid ester, polyoxyethanyl alkene fatty alcohol ethers, such as the poly- second of alkyl Glycol ethers, alkylsulfonate, alkyl sulfate, arylsulphonate or other protolysates.Useful dispersing agent includes: example Such as lignin sulfite waste liquor (lignosulphite waste liquors) and methylcellulose.
Tackifier, such as carboxymethyl cellulose, the natural and synthesis of powder, particle or latex form can be used in the formulation Polymer such as gum arabic, polyvinyl alcohol and polyvinyl acetate or other natural phospholipids such as cephalin and lecithin, Yi Jihe At phosphatide.Further additive can be mineral oil and vegetables.
Colorant such as inorganic pigment can be used, such as iron oxide, titanium dioxide and Prussian blue and organic dyestuff are such as The salt of alizarin dyes, azo dyes and metallized phthalocyanine dye and micronutrient such as iron, manganese, boron, copper, cobalt, molybdenum and zinc.
The active constituent weight contained in preparation is generally 0.1-95%, it is therefore preferable to 0.5-90%.
Seed treatment
The seed of processing plant has been known for for a long time, and is the theme continuously improved.However, in seed treatment In always cannot satisfactorily be solved there are also some problems.For example, it is desired to develop a kind of protection seed and germinating plants And finally the method for plant or plant parts, this method after planting or after plant germination, are just being avoided that or are at least significantly subtracting It is few additionally to use crop protection products.In addition it is also necessary to optimize the usage amount of reactive compound, maximumlly to protect seed With germinating plants from the invasion of Sclerotinia fungi, and the active constituent used will not damage plant itself.
Therefore, it is highly preferred that the present invention relates to by handling seed with succinate dehydrogenase inhibitors to control by seed The method of Sclerotinia fungi in the plant grown up to.The seed is more preferably, for example, the seed of soybean.
Germination present invention is equally related to succinate dehydrogenase inhibitors in processing seed to control seed and be grown up to by it The application of Sclerotinia fungi in plant and plant or plant parts.
Advantage of the invention first is that the distinctive absorbability based on the preferred fluopyram of succinate dehydrogenase inhibitors, Seed preferably is handled with fluopyram with succinate dehydrogenase inhibitors, the Sclerotinia that not only can control seeds self is true Bacterium can also control germination opisthogenesis in the Sclerotinia fungi of the plant of the seed.In this way, at seeding time or after planting Crop is immediately treated in short time with regard to unnecessary.
Equally also be considered as advantage is the preferred fluopyram of succinate dehydrogenase inhibitors, can be particularly applied to turn Gene seed.
Succinate dehydrogenase inhibitors, preferably fluopyram, suitable for making in protection agricultural, greenhouse, forest or gardens industry The seed of any plant variety.It is highly preferred that being cereal (such as wheat, barley, rye, millet and oat), corn, cotton Flower, soybean, rice, potato, sunflower, soya bean, coffee, beet (such as sugar beet and fodder beet), peanut, vegetables (example Such as tomato, cucumber, onion and lettuce), the seed of turfgrass and ornamental plant.Further preferably processing cereal (such as wheat, Barley, rye and oat), the seed of corn and rice.
In the context of the present invention, succinate dehydrogenase inhibitors, preferably fluopyram, can be individually or with appropriate Formulation application is in seed.Preferably, seed it is sufficiently stable to avoid it is undermined in processing in the state of handled.Generally Ground, can between harvesting and sowing whenever processing seed.It is usually used to be separated from plant and remove fringe Axis, shell, stem, epidermis, hair or pulp seed.Can be used for example by picking, cleaning and drying, water content is lower than The seed of 15wt%.Either, after drying also can be used, such as the seed then dried again by water process.
When handling seed, it is often necessary to ensure to be applied to the preferred fluopyram of succinate dehydrogenase inhibitors of seed And/or other selected amounts of additive, germination will not be injured, or the plant of generation will not be damaged as degree.Especially It is noted that may have the active constituent of phytotoxic effect in the case where specific application rate.
Succinate dehydrogenase inhibitors, preferably fluopyram can be applied directly, i.e., without containing it is any it is additional at Point, without dilution.Generally, it is preferred to which succinate dehydrogenase inhibitors, preferably fluopyram are applied with suitable dosage form For seed.The processing method of suitable preparation and seed is well known to those skilled in the art, and is described in for example following text In offering: 4,272,417 4,245,432 4,808,430 5,876,739 A, US 2003/ of A, US of A, US of A, US of US 0176428 A1、WO 2002/080675 A1、WO 2002/028186 A2。
Succinate dehydrogenase inhibitors workable for the present invention, preferably fluopyram can be converted to conventional seed dressing, Such as solution, emulsion, suspension, powder, foaming agent, slurries or other seed coat materials and ultra-low volume spray agent (ULV)。
These preparations, which can mix active constituent or active ingredient compositions with conventional additives, passes through known way system Standby, conventional additives are, such as conventional fillers and solvent or diluent, colorant, wetting agent, dispersing agent, emulsifier, defoaming Agent, preservative, secondary thickener, adhesive, gibberellin and water.
It can also be conventional use of all containing suitable colorant, including for this purpose in the seed dressing that the present invention uses Colorant.It can be used and be slightly soluble in the pigment of water and be dissolved in the dyestuff of water.Example includes following known colorant: rose-red (Rhodamine) B, C.I. paratonere (Pigment Red) 112 and C.I. tonyred (Solvent Red) 1.
Can also be containing suitable wetting agent in the seed dressing that the present invention uses, including humidity can be promoted and in agrochemicals Conventional use of all substances in active agent preparation, preferably available is alkylnaphthalene sulfonate, such as diisopropyl sulfonate or Diisobutyl naphthalene.
Agrochemicals can also be included in containing suitable dispersing agent and/or emulsifier in the seed dressing that the present invention uses Conventional use of all nonionics, anion and cation dispersing agent in active agent preparation.It is preferable to use nonionic or yin The mixture of ionic dispersants or nonionic or anionic dispersing agents.Suitable non-ionic dispersing agent preferably includes epoxy second Alkane-propylene oxide block polymer, alkyl phenol polyglycol ether and triphenylethylene phenol polyglycol ether and its phosphate or sulfuric acid Salt derivative.The preferred lignosulfonates of suitable anionic dispersing agents, polyacrylate and aromatic yl sulphonate-formaldehyde contracting Close object.
The suitable defoaming agent that can also contain in the seed dressing that the present invention uses, including it is used for agrochemicals for this purpose All foam mortifiers of active agent preparation.It is preferable to use silica gel defoaming agent and magnesium stearates.
Suitable preservative can also be contained in the seed dressing that the present invention uses, including for this purpose conventionally used for agriculturalization The all substances of length of schooling agent.Example includes Dichlorophenol and phenmethylol hemiformal.
Can also be containing applicable secondary thickener in the seed dressing that the present invention uses, including it is used for agriculturalization for this purpose The all substances of length of schooling agent.Preferred example includes cellulose derivative, acrylic acid derivative, xanthan gum, modified clay and thin Grind silica.
Also containing applicable adhesive in the seed dressing that the present invention uses, including all normal of seed dressing composition can be used for Advise adhesive.Preferred example includes polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and hydroxyethyl cellulose (tylose)。
Also containing suitable gibberellin, preferably gibberellin A1, A3 (=puppet gibberellic acid), A4 in the seed dressing that the present invention uses And A7, particularly preferably pseudo- gibberellic acid.Gibberellin is known (referring to R.Weglaer " Chemie der Pflanzenschutz-und- smittel " [crop protection chemistry and injurious insect control combination Object (Chemistry of Crop Protection and Pest Control Compositions)], Vol.2, Springer Verlag,1970,pp.401-412)。
The seed dressing that the present invention uses directly can use or be diluted with water the numerous different types of seeds of post-processing.Example Such as, it with concentrate or preparation made from the concentrate can be diluted with water dresses seed to cereals seed, such as wheat, barley, black Wheat, the seed of oat and triticale and corn, rice, rape, pea, soya bean, cotton, sunflower and beet seed, or Other numerous different types of vegetable seeds.The seed dressing or their diluent that the present invention uses can also be used for genetically modified plants The seed dressing of seed.In this case, it also can produce other synergistic effect with the interaction by expression institute's forming material.
Handle seed with the seed dressing that uses of the present invention or to the preparation that above-mentioned seed dressing adds water to prepare, it is all conventionally used for The mixing apparatus of seed dressing all can be used.Specific seed dressing program are as follows: seed is placed in mixer, be added Seed dressing formulations itself or Specific required dosage after being diluted with water in advance, is then mixed until preparation is evenly distributed on seed.Next may be used Operation is dried.
The rate of application for the seed dressing that the present invention uses can change in relatively wide range.This depends on living in preparation The specific concentration and seed of property ingredient.In general, the rate of application of active ingredient compositions is 0.001~50g in every kilogram of seed, it is excellent Select 0.01~15g in every kilogram of seed.
The present invention especially preferably handles plant that is available commercial or using or Plant cultivars.Plant culture product Kind should be understood to have new characteristic (" character ") and pass through conventional breeding, by mutation breeding or by recombinant DNA technology The plant of acquisition.Therefore, crop plants can be through conventional breeding and optimization method, or pass through biotechnology and gene work Cheng Fangfa or its combine method obtain plant, including genetically modified plants and can with or cannot obtain Plant variety right protect The plant variety of shield.
Therefore, method of the invention can be used for handling the organism (GMOs) of improvement of genes, such as plant or seed.Base Because the plant (or genetically modified plants) of improvement be foreign gene it is stable be integrated into genomic plant.Term " foreign gene " It is substantially a kind of gene, which provided or recombinate in vitro in plant, is once imported into nuclear genome, is passed through Express express target protein matter or polypeptide, or through other genes present in another gene present in plant or plant by under It adjusts or silencing (such as pass through: antisense technology, co-suppression technology or RNAi technology (RNA interference)), in the leaf of the plant of conversion New or improvement agronomy or other characters are assigned in green body genome or grain wire body genome.The external source being present in genome Gene is also referred to as metastatic gene.According to its specific position in the plant genome, metastatic gene is referred to as genetic transformation or turns Gene event (event).
The plant of preferred process of the present invention and Plant cultivars include all plants, and the plant has energy will be specific Advantageous and useful character pass to the hereditary information of other plants and (whether cultivated by breeding and/or biotechnological ways It obtains not important).
The also accessible plant of the present invention and Plant cultivars are resistant to one or more abiotic stress Plant.The factor of abiotic stress may include as arid, low temperature exposure, heat exposure, osmotic pressure, waterlogging, soil high salt, High mineral concentration, ozone, the exposure of strong light, nitrogen nutrition elements fed is limited, phosphorus nutrition elements fed is limited or shade is kept away.
The accessible plant of the present invention and Plant cultivars are the plant with increased this properties and characteristics of yield.Institute Stating increased yield in plant can be for as improved plant physiology, growth and development, such as efficiency of water application, water retention improves nitrogen benefit With rate, carbon assimilation is improved, photosynthesis is improved, germination percentage is improved and accelerates mature result.It can be by improving the plant type (side of body Compel it is lower under non-stress condition) further influence yield, including but not limited to, bloom ahead of time, control and bloom to generate and hybridize Seed, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, fruit pod size, fruit Pod or spike number amount, the seed amount of every pod or every fringe, seed quality, reinforcement seed plumpness, reduction seed are scattered, reduce fruit pod Cracking with it is resistant to lodging.Other yield traits include seed compositions, as carbohydrate content, protein content, oil content at Divide, nutritive value, reduce bad nutrient compound, improve machinability and improve storage stability.
The plant that can be handled according to the present invention is to have shown heterologous or hybrid vigour character hybrid plant, the hybridization Plant may generally be high yield, vigor, health and to biology and abiotic stress factor it is resistant.The plant is usually logical It crosses to hybridize male sterility self-mating system parent (female parent) with other male-fertile self-mating system parents (male parent) and be made.Hybrid seed is logical Often then harvest is sold to grower from male sterility parent.Male sterile plants (such as corn) sometimes can be by emasculation system , i.e., by mechanical removal Male reproductive organ (or male flower), but more commonly gene determinant is made in Plant Genome At male sterility.In this case, especially when the seed harvested in hybrid plant be required product when, usually can ensure that containing The hybrid plant for being responsible for the gene determinant of male fertility restores male fertility completely.This can be by ensuring that male parent has Appropriate restoring gene can make to come containing the hybrid plant recovery male fertility for being responsible for male sterile gene determinant It completes.Male sterility gene determinant can be located in cytoplasm.The example of cytoplasmic male sterility (CMS) is in such as Btassica (Brassica) (WO 1992/005251, WO 1995/009910, WO 1998/27806, WO 2005/ are had been described in plant 002324,WO 2006/021972 and US 6,229,072).However, male sterility gene determinant may be alternatively located at nucleus In genome.The acquisition of Plant Biotechnology method, such as genetic engineering can also be used in male sterile plants.Obtain male sterile plants Particularly suitable method be disclosed in WO 89/10396, wherein such as ribalgilase, such as barnase (barnase) Selectively expressed in the tapetal cell of stamen.Inhibited by ribalgilase repressor, such as barnase Expression of the agent (barstar) in tapetal cell can restore fertility (such as WO 1991/002069).
The accessible plant of the present invention or Plant cultivars (can be obtained by Plant Biotechnology method, such as genetic engineering ) it is herbicide tolerant plants, it can it is resistant to the plant of one or more particular herbicides.The plant, which can be used, turns base Because method or screening are obtained comprising the plant of herbicide-resistance mutations.
Herbicide-resistance plant is such as Glyphosate resistant plants, it can the plant of resistance glyphosate herbicide or its salt. For example, Glyphosate resistant plants can be by converting coding 5- enol pyruvylshikimate -3- phosphate synthase in plant (EPSPS) gene obtains.The example of the EPSPS gene is the AroA of salmonella (Salmonella typhimurium) Gene (mutant strain CT7) (Comai et al., Science (1983), 221,370-371), Agrobacterium (Agrobacterium Sp.) the CP4 gene (Barry et al., Curr.Topics Plant Physiol. (1992), 7,139-145) of bacterium, coding Petunia EPSPS (Shah et al., Science (1986), 233,478-481), tomato EPSPS (Gasser et al., J.Biol.Chem. (1988), 263,4280-4289) or herba eleusines indicae EPSPS (WO 2001/66704) gene.It can also be The EPSPS of mutation, such as it is described in EP-A 0837944, WO 2000/066746, WO 2000/066747 or WO 2002/ 026995.Glyphosate resistant plants can also encode the gene acquisition of glyphosate oxidoreductase by expressing, and be described in US 5, 776,760 and US 5,463,175.Glyphosate resistant plants can also encode the gene of glyphosate acetyl based transferase by expressing It obtains, is described in such as WO 2002/036782, WO 2003/092360, WO 2005/012515 and WO 2007/024782. Glyphosate resistant plants can also be obtained by screening the plant of the natural mutation comprising said gene, be described in such as WO 2001/ 024615 or WO 2003/013226.
Other herbicide resistant plants, the herbicide of the resistance to suppressed glutamine synthelase such as prepared, such as double third The plant of amine phosphine, glufosinate-ammonium or glufosinate.The preparation method of the plant can release the enzyme of herbicide toxicity by expressing Or the mutation glutamine synthelase of the inhibition can be resisted and obtained.One of enzyme for effectively releasing toxicity is for example to encode careless ammonium Phosphinothricin acetyl transferase (bar the or pat albumen as come from streptomyces (Streptomyces)).US 5,561,236；US 5, 648,477；US 5,646,024；US 5,273,894；US 5,637,489；US 5,276,268；US 5,739,082；US 5,908,810 and US 7,112,665 also illustrates the plant of expression external source glufosinate-ammonium transacetylase.
Further herbicide resistant plants are also possible to the resistance to suppressed p- hydroxyphenyl pyravate dual oxide prepared The plant of the herbicide of enzyme (HPPD).P- p- hydroxyphenyl pyruvate acid esters (HPP) conversion of hydroxyphenyl pyravate dual oxide enzymatic At alkapton.According to WO 1996/038567, WO 1999/024585 and WO 1999/024586, the plant of resistance to HPPD inhibitor It can be obtained by the gene of the HPPD enzyme of the gene or encoding mutant of conversion coding natural resistance HPPD enzyme.Although HPPD inhibits Agent inhibits natural HPPD enzyme, with the gene-transformed plant for encoding certain enzymes for being capable of forming alkapton, also can get and presses down to HPPD The patience of preparation.These plants and gene are described in WO 1999/034008 and WO 2002/36787.WO 2004/024928 In describe plant to the patience of HPPD inhibitor, outside the gene-transformed plant except through coding HPPD- tolerance enzyme, can also lead to It crosses and is improved with the gene-transformed plant of coding prephenate dehydrogenase.
Other herbicide resistant plants can be the plant of resistance to acetolactate synthestase (ALS) inhibitor prepared. Known ALS- inhibitor includes such as sulfonylureas, imidazolone type, triazolo pyrimidine class, pyrimidine radicals oxygen (sulphur) benzoates And/or sulfonyl amido carbonyltriazolinone herbicide.Mutant (the also referred to as acetyl group carboxylic acid of known difference ALS enzyme Synzyme, AHAS) tolerance can be assigned to different herbicides and inhomogeneity herbicide, it is described in such as Tranel and Wright, Weed Science (Weed Science) (2002), 50,700-712 and US 5,605,011, US 5,378,824, US 5, 141,870 and US 5,013,659.US 5,605,011,US 5,013,659,US 5,141,870,US 5,767,361,US 5,731,180, US 5,304,732, US 4,761,373, US 5,331,107, US 5,928,937 and US 5,378,824 In and international publication WO 1996/033270 in disclose sulfonylureas tolerance plant and imidazolone type tolerance plant Preparation.Other imidazolone type tolerance plants are also described in such as WO 2004/040012, WO 2004/106529, WO 2005/ 020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO 2006/ 060634.Other sulfonylureas and imidazolone type tolerance plant are also described in such as WO 2007/024782.
The plant of other resistance to imidazolone types and/or sulfonylureas can pass through mutagenesis, progress cell training in the presence of herbicide It supports selection or mutation breeding obtains, for example, being described in US 5,084,082 for soybean；For rice, it is described in WO In 1997/41218；For beet, it is described in US 5,773,702 and WO 1999/057965；For lettuce, it is described in US In 5,198,599；Or it for sunflower, is described in WO 2001/065922.
(by Plant Biotechnology method, such as: genetic engineering obtains for the also accessible plant of the present invention or Plant cultivars ) it is insect-resistant transgenic plants, i.e., certain targeted insects are encroached on resistant plant.This kind of plant can be by transgenosis side Method, or the plant that screening is mutated containing insect resistace obtain.
The term as used herein " insect-resistant transgenic plants " includes any plant comprising at least one transgenosis, and described turn Gene includes to encode following coded sequences:
1) the insecticidal crystal albumen from bacillus thuringiensis (Bacillus thuringiensis) or its desinsection portion Point, such as it is recorded in Crickmore, microbiology and molecular biology summarize (Microbiology and Molecular Biology Reviews) (1998), 62,807-813, it is named by Crickmore etc. (2005) in B. thuringiensis Toxin It is updated in (Bacillus thuringiensis toxin nomenclature), network address: http: // Www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/ insecticidal crystal albumen or its insecticidal part), Such as PROTEIN C ry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Ae or Cry3Bb or its insecticidal part of Cry protide；Or
2) crystalline protein or part thereof from bacillus thuringiensis, in second from bacillus thuringiensis There is pesticidal, to be such as made of Cry34 and Cry35 crystalline protein binary toxin in the presence of other crystalline proteins or part thereof (Moellenbeck etc., Nat.Biotechnol. (2001), 19,668-72；Schnepf etc., Applied Environm.Microb.(2006),71,1765-1774)；Or
3) comprising for example above-mentioned hybrid proteins 1) of the different insecticidal crystal albumen from bacillus thuringiensis or it is above-mentioned 2) Hybrid proteins hybrid insecticidal proteins, such as by corn event MON98034 (WO 2007/027777) generate Cry1A.105 albumen；Or
4) above-mentioned 1) any protein into 3) item, some of them amino acid, especially 1-10 amino acid are another A amino acid substitution can generate higher insecticidal activity to targeted insect, and/or can expand the range of impacted targeted insect, And/or change caused by due in clone or conversion process in coding DNA, as: corn variety MON863 or MON88017 The Cry3A albumen of Cry3Bb1 albumen or corn variety MIR604；Or
5) the desinsection secretory protein from bacillus thuringiensis or Bacillus cercus (Bacillus cereus) or Its insecticidal part, such as: Vegetative Insecticidal Proteins (VIP) are listed in: http://www.lifesci.sussex.ac.uk/ Home/Neil_Crickmore/Bt/vip.html, such as: the albumen from VIP3Aa protide；Or
6) secretory protein from bacillus thuringiensis or Bacillus cercus is coming from bacillus thuringiensis Or have in the presence of the second secretory protein of Bacillus cercus it is pesticidal, such as: two be made of VIP1A and VIP2A albumen First toxin (WO 1994/21795)；Or
7) comprising the hybrid of the part including different secretory proteins from bacillus thuringiensis or Bacillus cercus Insecticidal proteins such as include: above-mentioned hybrid proteins or above-mentioned hybrid proteins 2) 1)；Or
8) above-mentioned 1) any protein into 3) item, some of them amino acid, especially 1-10 amino acid is by another Amino acid substitution can generate higher insecticidal activity to targeted insect, and/or can expand impacted targeted insect range, and/or Caused change (but still codified insecticidal proteins) in the DNA encoded in clone or conversion process, such as: cotton variety COT102 VIP3Aa albumen.
Certainly, insect-resistant transgenic plants as described herein also include containing the gene for encoding the above-mentioned any albumen of 1 to 8 class Any plant of combination.In a specific embodiment, insect-resistant transgenic plants contain any there are many above-mentioned 1 to 8 class is encoded The metastatic gene of kind albumen by using different insecticidal proteins to same class targeted insect, but has different binding modes, Different receptor binding sites are integrated in insect, such as to expand the range of impacted target insect species or delay insect to plant The resistance development of object.
The also accessible plant of the present invention or Plant cultivars (being obtained by Plant Biotechnology method, such as genetic engineering) It can be with resisting abiotic stress factor.The plant can have the mutant for resisting above-mentioned stress by transgene method or screening It obtains.The plant of particularly useful anti-stress includes:
A. comprising can reduce expression/of poly- (ADP- ribose) polymerase (PARP) gene in plant cell or plant or The plant of active transgenosis is described in WO 2000/004173 or EP 04077984.5 or EP 06009836.5；
It b. include the expression and/or active anti-stress ability that can reduce the PARG encoding gene of plant or plant cell The plant of the transgenosis of enhancing, such as it is described in WO 2004/090140；
It c. include the Plant functional enzyme of encoding nicotinamide adenine-dinucleotide salvage route, including niacinamide Enzyme, nicotinate ribose phosphate invertase, nicotinic acid single nucleotide adenyl invertase, nicotinamide adenine dinucleotide synzyme Or the plant of the transgenosis of the anti-stress ability enhancing of Nicotinic Acid Amide ribose phosphate invertase, it is described in such as EP 04077624.7 or WO 2006/133827 or PCT/EP07/002433.
The also accessible plant of the present invention or Plant cultivars (are made, such as genetic engineering by Plant Biotechnology method Obtaining) product that is harvested shows yield and quality and/or storage stability is changed and/or changes harvested product Special component character, such as:
1) genetically modified plants of synthesis modification starch, relative to starch synthesized by wild type plant cell or plant, In physicochemical characteristics, especially amylose content or amylose/amylopectin ratios, branch degree, average chain Length, side chain distribution, viscosity performance, gel strength, amylum body size and/or morphology of starch grain etc. have changed, therefore more Suitable for specific use.The genetically modified plants of synthesis modification starch are described in for example, EP 0571427, WO 1995/ 004826、EP 0719338、WO 1996/15248、WO 1996/19581、WO 1996/27674、WO 1997/11188、WO 1997/26362、WO 1997/32985、WO 1997/42328、WO 1997/44472、WO 1997/45545、WO 1998/ 27212、WO 1998/40503、WO 99/58688、WO 1999/58690、WO 1999/58654、WO 2000/008184、WO 2000/008185、WO 2000/28052、WO 2000/77229、WO 2001/12782、WO 2001/12826、WO 2002/ 101059、WO 2003/071860、WO 2004/056999、WO 2005/030942、WO 2005/030941、WO 2005/ 095632、WO 2005/095617、WO 2005/095619、WO 2005/095618、WO 2005/123927、WO 2006/ 018319、WO 2006/103107、WO 2006/108702、WO 2007/009823、WO 2000/22140、WO 2006/ 063862、WO 2006/072603、WO 2002/034923、EP 06090134.5、EP 06090228.5、EP 06090227.7、EP 07090007.1、EP 07090009.7、WO 2001/14569、WO 2002/79410、WO 2003/ 33540、WO 2004/078983、WO 2001/19975、WO 1995/26407、WO 1996/34968、WO 1998/20145、 WO 1999/12950、WO 1999/66050、WO 1999/53072、US 6,734,341、WO 2000/11192、WO 1998/ 22604、WO 1998/32326、WO 2001/98509、WO 2001/98509、WO 2005/002359、US 5,824,790、 US 6,013,861, WO 1994/004693, WO 1994/009144, WO 1994/11520, WO 1995/35026 and WO 1997/20936。
2) non-starch carbohydrate polymer or the synthesis character compared with the wild-type plant without improvement of genes are synthesized The genetically modified plants of the non-starch carbohydrate polymer of change.The example is the plant for generating Fructooligosaccharides, espespecially synanthrin type With fructan-type, it is described in EP 0663956, WO 1996/001904, WO 1996/021023, WO 1998/039460 and WO 1999/024593；α-Isosorbide-5-Nitrae glucan plant is generated, WO 1995/031553, US 2002/031826, US 6 are described in, 284,479, US 5,712,107, WO 1997/047806, WO 1997/047807, WO 1997/047808 and WO 2000/ 14249；α -1 is generated, the plant of 6 branched alphas-Isosorbide-5-Nitrae glucan is described in WO 2000/73422；It generates alternan (alternan) Plant, be described in WO 2000/047727, EP 06077301.7, US 5,908,975 and EP 0728213.
3) genetically modified plants of sodium hyaluronate (hyaluronan) are generated, such as are described in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006/304779 and WO 2005/012529.
According to the present invention also accessible plant or plant variety (by Plant Biotechnology, for example, genetic engineering and obtain ) be the fibre property with change plant, such as vegetable lamb.The plant can contain by genetic transformation or by screening There is the mutant plant for the fibre property that can assign the change and obtain, the plant includes:
A) plant of the Cellulose-synthase gene changed containing form, such as vegetable lamb, are described in WO 1998/ 000549；
B) plant of the rsw2 or rsw3 homologous nucleotide changed containing form, such as vegetable lamb, are described in WO 2004/053219；
C) plant of sucrose phosphosynthase expression enhancing, such as vegetable lamb, are described in WO 2001/017333；
D) plant of Sucrose synthesis expression of enzymes enhancing, such as vegetable lamb, are described in WO 02/45485；
When e) as changed fibrocyte base portion plasmodesmus gate by lowering fiber selectivity beta-1,3-glucanase Between plant, such as vegetable lamb is described in WO 2005/017157；
F) such as pass through the expression of N-Acetyl-D-glucosamine transferase gene and chitin synthetase gene including nodC The plant of fiber reactivity, such as vegetable lamb are changed, WO 2006/136351 is described in.
The plant that can also handle according to the present invention or plant variety (by Plant Biotechnology, for example, genetic engineering and obtain ) be the oil component characteristic with change plant, such as rape or related Brassica plants.The plant can pass through heredity Conversion is obtained by screening the mutant plant containing the oily characteristic that can assign the change, and the plant includes:
A) plant with the oil of high oleic acid content, such as rapeseed plant are generated, such as US 5,969,169, US are described in 5,840,946 or US 6,323,392 or US 6,063,947；
B) plant with the oil of low linolenic, such as rapeseed plant are generated, US 6,270828, US 6 are described in, 169,190 or US 5,965,755；
C) plant with the oil of low-level saturated fatty acid, such as rapeseed plant are generated, such as US 5 is described in, 434,283。
The particularly useful genetically modified plants that can be handled according to the present invention are one or more containing one or more codings The plant of the gene of toxin, for following commercially available genetically modified plants of trade name: YIELD(such as corn, Cotton, soybean),(such as corn),(such as corn),(such as corn),(such as corn),(cotton),(cotton), Nucotn(cotton),(such as corn),WithThe plant of (potato).The herbicide that can be mentioned that The example of tolerant plants has following commercially available trade name Roundup(there is tolerance to glyphosate, such as beautiful Rice, cotton, soybean), Liberty(there is tolerance, such as rape to glufosinate),(to imidazolone type With tolerance) andCorn variety, cotton variety and the soybean product of (there is tolerance, such as corn to sulfonylurea) Kind.The herbicide resistant plants (plant of breeding in a manner of conventional herbicide tolerant) that can be mentioned that include commercially available trade name ForThe kind of (such as corn).
The particularly useful genetically modified plants that can be handled according to the present invention are to combine containing transformation event or transformation event Plant, the plant be listed in the database of for example multiple country management organizations (see, e.g.http:// gmoinfo.jrc.it/gmp_browse.aspxWithhttp://www.agbios.com/dbase.php)。
Preparation:
Succinate dehydrogenase inhibitors of the invention, preferably fluopyram can reside in its commercially available obtainable system In agent, and can reside in the application form prepared by these preparations, as with other active constituents such as insecticide, lure worm Agent, disinfectant, bactericide, acaricide, nematicide, fungicide, growth regulator, herbicide, safener, fertilizer or change Learn the mixture of information substance (semiochemicals).
In addition, succinate dehydrogenase inhibitors described above, preferably fluopyram, in control Sclerotinia fungi Positive effect can be improved by being further processed with desinsection, antifungal or bactericidal effective component.
Azole compounds are used to enhance the preferred application multiple of abiotic stress resistance, with the utility ratio that is approved to soil Earth, stem and/or leaf are handled.
Succinate dehydrogenase inhibitors of the invention, preferably fluopyram, can generally be additionally present in its it is commercially available can In the preparation of acquisition, and can reside in the application form prepared by these preparations, as with other active constituents such as desinsection Agent, attractant, disinfectant, acaricide, nematicide, fungicide, growth regulator or herbicide mixture.
The following examples are not limited to the present invention for illustrating the present invention.
Embodiment 1
In Brazil, according to the condition of agricultural practice, plot experiment (plot is carried out to soybean varieties Monsoy7908 RR Test), it is therefore an objective to the anti-sclerotinite effect of detection fluopyram when spraying application.
Product to be detected is sprayed application on plant according to sequence is sprayed.
Every can be to differ for 2-3 weeks during the spraying of individual plant.
Fluopyram is with 500SC preparation (preparation number SP102000016460) application, utility ratio 150,200 and 250g a.i./ha (gram effective component/hectare).The per hectare amount of spraying is 300L water.
30 days after spraying for the third time, in area, examination plot (plot) visual assessment controls success rate.In area's examination block part It is graded by count to infected plant.Then effect is calculated by Abbott Laboratories' formula (Abbott formula).
The table 1 that infected quantity is seen below.
The effect of sclerotinite in the anti-soybean of 1 fluopyram of table

Claims (3)

1. succinate dehydrogenase inhibitors answering in the sclerotinite (Sclerotinia sclerotiorum) in control plant With the succinate dehydrogenase inhibitors are fluopyram (N- { [3- chloro- 5- (trifluoromethyl) -2- pyridyl group] ethyl } -2- Trifluoromethyl benzamide), soybean of the plant for 10 phase of BBCH or later, wherein the dosage of the fluopyram is 100-250g/ha。
2. application according to claim 1, it is characterised in that the plant is genetically modified plants.
3. application according to claim 1, it is characterised in that the succinate dehydrogenase inhibitors are killed with other activity Fungi ingredient is applied in combination.
CN201510459602.8A 2009-06-02 2010-05-26 Application of the succinate dehydrogenase inhibitors in control Sclerotinia fungi Active CN105165832B (en)

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EP09161671.4 2009-06-02
EP09161671 2009-06-02
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