CN1048175C

CN1048175C - Oral liquid for regulating women's sexual function

Info

Publication number: CN1048175C
Application number: CN95104292A
Authority: CN
Inventors: 杨泽林; 梁茂新; 杨金庆; 李绍华; 周巧兰; 李东安; 刘云锋; 李伟
Original assignee: HONGBAO PHARMACEUTICAL CO Ltd HEBEI PROV
Current assignee: HONGBAO PHARMACEUTICAL CO Ltd HEBEI PROV
Priority date: 1995-05-02
Filing date: 1995-05-02
Publication date: 2000-01-12
Anticipated expiration: 2015-05-02
Also published as: CN1134824A

Abstract

The present invention relates to a preparation of oral liquid for regulating female sexual functions. The preparation is composed of prepared rehmannia root, desertliving cistanche, epimedium herb, white peony root, barbary wolfberry fruit and other kinds of Chinese herbal medicine. The preparation is used for treating female sexual hypofunction, menoxenia, soreness and weakness of waist and knees, mental deficiency, amnesia and other pathological symptoms in clinic. Pharmacological tests and clinical verification show that the oral liquid has the functions of nourishing blood for regulating menstruation, tonifying the liver and the kidney and nourishing yin for tranquillization, and the oral liquid relieves pains for patients.

Description

A kind of oral liquid of regulating women's sexual function

The present invention relates to a kind of oral liquid of regulating women's sexual function, belong to health care medicine.

In recent years, research and development along with sex medicine, Chinese medicine and pharmacy has had some experiences to understanding and the treatment that women's sexual function goes down, as Li Yuyou to amenorrhea and the indifferent person of libido due to the obesity, control from stagnation of phlegm-damp, the cloudy depressed opinion of spleen, the side adds flavor (cognition of " the new traditional Chinese medical science in Tianjin " 1990.7.17 treatment amenorrhea) with the grey attached expectorant ball of leading, and is sombre for the women, Wang Wanzu is from the insufficiency of kidney-YANG diagnosis and treatment, with warm palace soup with disease adaptability in tactics (" the Sichuan traditional Chinese medical science " 1992.4.46. temperature palace soup treatment married woman is sombre); Zhang Chaojun then sombrely obtains effect with the treatment of self-control wine of sheep kidney; (treatment of " the Sichuan traditional Chinese medical science " 1995.5.37 wine of sheep kidney is sombre) Zheng Chunlei is to the sombre double bitter taste of seeing of women, costalgia person, examine and be dampness-heat in the liver and gallbladder disease, the side is sombre with Decoction of Gentiana for Purging the Liver-fire treatment) (treatment of " the Sichuan traditional Chinese medical science " 1990.1.42. Decoction of Gentiana for Purging the Liver-fire is sombre) bibliographic reference shows, being used for the treatment of women's sexual function now goes down, the menoxenia companion sees irritability, insomnia, lethargy, forgetful, many symptoms such as depression, the clinical doctor of polyphyly draws up prescription, the patient oneself decocts into decoction and takes, extremely inconvenient, in addition, these clinical reports of testing controlled are not all from the clear and definite side's medicine of experimental viewpoint mechanism of action with the pharmacodynamics data are provided.

The objective of the invention is to release a kind of fixed oral liquid formulation and go down to treat women's sexual function clinically, many symptoms of climacteric syndrome and association as a kind of pure Chinese medicine health-care medicine, guarantee the curative effect and the quality of medicine.

This health care medicine of the present invention is pure Chinese medicinal components, in order to regulate women's sexual function.Dosage form is an oral liquid, and its crude drug is formed and comprised (W/W)

Radix Rehmanniae Preparata 8-12%, Herba Cistanches 6-10%, Herba Epimedii 6-10%, Radix Paeoniae Alba 6-10%, Fructus Ligustri Lucidi 5-8%, Fructus Corni 5-8%, Fructus Lycii 5-8%, Caulis Spatholobi 5-8%, Radix Salviae Miltiorrhizae 3-6%, Radix Dipsaci 4-8%, Semen Ziziphi Spinosae (parched) 4-8%, Radix Angelicae Sinensis 5-8%, Cortex Phellodendri 5-8%, Rhizoma Anemarrhenae 5-8%, Cortex Moutan 3-6% Rhizoma Chuanxiong 2-5%.Oral liquid is the concentrated extract of above crude drug component.

The formulation method of this oral liquid comprises that the crude drug component is added moisture decocts filtration three times, merging filtrate is concentrated into relative density 1.0-1.2, adding 95% ethanol makes pure content reach 70%, fully stir evenly, left standstill 24 hours, filter, reclaim ethanol, add correctives, antiseptic, adding the ratio that entry makes crude drug and oral liquid is 1: 1.

The oral liquid of adjusting women's sexual function of the present invention is earlier with the nourishing blood for regulating menstruation, liver and kidney tonifying is attached most importance to, from the fixing Chinese medicine component Cheng Fang of dosage form, confirm through preclinical pharmacology, this oral liquid can significantly shorten rat incubation period emotionally, improve estradiol content in the teenage female Mus serum, improve the dispirited degree of going to ovum female mice uterus, increase adrenal gland's weight, certain calmness and resisting fatigue are also arranged, oxygen lack resistant function (seeing Appendix 1,2) clinical observation shows that oral liquid of the present invention has nourishing blood for regulating menstruation, the function of liver and kidney tonifying, nourishing YIN for tranquillization.Be applicable to women's deficiency of the liver and kindey, hyposexuality due to vim and vigour are uncomfortable, vaginal dryness, lethargy, have a dizzy spell, disease such as fidgety irritability, insomnia forgetfulness, soreness of the waist and knees, menoxenia, total effective rate is 93%, has the effect of paying of the obvious no any poison of effect (seeing Appendix 3) that improves women's sexual function and 9 sees Appendix 4,5) oral liquid of the present invention is significant to numerous women's psychosomatic health.

Below in conjunction with embodiment, describe technology contents of the present invention in detail.

1. female gentle liquid (trade name) prescription is formed;

The Radix Rehmanniae Preparata 90 gram Herba Cistanches 80 gram Herba Epimedii 80 gram Radix Paeoniae Alba 80 gram Fructus Ligustri Lucidi 60 Keshan dish cornels 60 gram Fructus Lycii 60 gram Caulis Spatholobis 60 gram Radix Salviae Miltiorrhizaes 50 gram Radix Dipsacis 40 gram Semen Ziziphi Spinosae (parched)s 40 gram Radix Angelicae Sinensis 60 gram Cortex Phellodendris 80 gram Rhizoma Anemarrhenaes 80 gram Cortex Moutans 50 gram Rhizoma Chuanxiongs 30 gram sodium benzoate 3 gram steviosides are an amount of.

Above crude drug is decocted with water 3 times, add 10 times in water, decoct filtration in 2 hours for the 1st time; Add 8 times in water the 2nd time, decocted 1.5 hours, filter; Add 6 times in water the 3rd time, decocted 1 hour, and filtered, merging filtrate is concentrated into relative density 1.1-1.2, adding 95% ethanol makes and contains alcohol amount and reach 70%, fully stir evenly, leave standstill after 24 hours and filter recovery ethanol, add sodium benzoate, stevioside makes into the 1000ml heated and boiled with water, leaves standstill filtration, and packing promptly.

Embodiment 2, and female gentle liquid (trade name) prescription is formed

The Radix Rehmanniae Preparata 90 gram Herba Cistanches 80 gram Herba Epimedii 80 gram Radix Paeoniae Alba 80 gram Fructus Ligustri Lucidi 60 Keshan Fructus Evodiaes 60 gram Fructus Lycii 60 gram Caulis Spatholobis 60 gram Radix Salviae Miltiorrhizaes 50 gram Radix Dipsacis 40 gram Semen Ziziphi Spinosae (parched)s 40 gram Radix Angelicae Sinensis 60 gram Cortex Phellodendris 80 gram Rhizoma Anemarrhenaes 80 gram Cortex Moutans 50 gram Rhizoma Chuanxiongs 30 gram sodium benzoate 3 gram steviosides are an amount of.

Preparation method is with embodiment 1.

Claims

1, a kind of oral liquid of regulating women's sexual function is characterized in that it is the medicament of being made by following materials of weight proportions medicine: Radix Rehmanniae Preparata 8-12%, Herba Cistanches 6-10%, Herba Epimedii 6-10%, Radix Paeoniae Alba 6-10%, Fructus Ligustri Lucidi 5-8%, Fructus Corni 5-8%, Fructus Lycii 5-8%, Caulis Spatholobi 5-8%, Radix Salviae Miltiorrhizae 3-6%, Radix Dipsaci 4-8%, Semen Ziziphi Spinosae (parched) 4-8, Radix Angelicae Sinensis 5-8%, Cortex Phellodendri 5-8%, Rhizoma Anemarrhenae 5-8%, Cortex Moutan 3-6%, Rhizoma Chuanxiong 2-5%.

2, a kind of preparation method of regulating the oral liquid of women's sexual function comprises that the crude drug component with following weight proportion adds three decoction filtering of moisture: Radix Rehmanniae Preparata 8-12%, Herba Cistanches 6-10%, Herba Epimedii 6-10%, Radix Paeoniae Alba 6-10%, Fructus Ligustri Lucidi 5-8%, Fructus Corni 5-8%, Fructus Lycii 5-8%, Caulis Spatholobi 5-8%, Radix Salviae Miltiorrhizae 3-6%, Radix Dipsaci 4-8%, Semen Ziziphi Spinosae (parched) 4-8, Radix Angelicae Sinensis 5-8%, Cortex Phellodendri 5-8%, Rhizoma Anemarrhenae 5-8%, Cortex Moutan 3-6%, Rhizoma Chuanxiong 2-5%, merging filtrate is concentrated into relative density 1.1-1.2, adding 95% ethanol makes pure content reach 70%, fully stir evenly, left standstill 24 hours, filter, reclaim ethanol, add school flavor agent, antiseptic, adding the ratio that entry makes crude drug and oral liquid is 1: 1.