CN1500513A - Instant traditional Chinese medicine formulation for headache - Google Patents
Instant traditional Chinese medicine formulation for headache Download PDFInfo
- Publication number
- CN1500513A CN1500513A CNA021486654A CN02148665A CN1500513A CN 1500513 A CN1500513 A CN 1500513A CN A021486654 A CNA021486654 A CN A021486654A CN 02148665 A CN02148665 A CN 02148665A CN 1500513 A CN1500513 A CN 1500513A
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- Prior art keywords
- headache
- chinese medicine
- blood
- electuary
- medicine
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003814 drug Substances 0.000 title claims abstract description 29
- 206010019233 Headaches Diseases 0.000 title claims abstract description 25
- 231100000869 headache Toxicity 0.000 title claims abstract description 25
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241000218176 Corydalis Species 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 241000217407 Margaritifera Species 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000012869 ethanol precipitation Methods 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000012567 medical material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 241000157352 Uncaria Species 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 235000008113 selfheal Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 24
- 210000004369 blood Anatomy 0.000 description 24
- 208000002193 Pain Diseases 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 5
- 206010061245 Internal injury Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 208000019695 Migraine disease Diseases 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 206010027599 migraine Diseases 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 229940095559 cafergot Drugs 0.000 description 2
- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000001631 hypertensive effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 1
- 206010019705 Hepatic pain Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine granule for treating headache has the ingredients including angelica 4-9 wt%, Chuanxiong rhizome 4-9 wt%, white peony root 2-8 wt%, prepared rhizome of rehmannia 2-8 wt%, hooked uncaria 10-15 wt%, spatholobus stem 10-15 wt%, selfheal 10-15 wt%, cassia seed 10-15 wt%, nacre 10-15 wt%, corydalis tuber 4-9 wt% and asarum herb 0.5-2 wt%. The present invention has the features of high performance, easy preparation and low cost.
Description
Affiliated field
The invention belongs to the Chinese patent medicine that pure Chinese medicinal plant is made, it relates to the component and the manufacturing process of this patent medicine.
Background technology
Angioneurotic headache is a kind of commonly encountered diseases, though there is the part Chinese and western drugs to use, effect is all not satisfactory, especially to the treatment blood deficiency.The medicine of the headache due to hyperactivity of liver-YANG of blood stasis type document both domestic and external still is not reported, and the existing Western medicine for the treatment of headache of being in harmony commonly used has cafergot, and it is a kind of vasodilation, only is suitable for the cerebral artery ischemia disease.The flunarizine capsule of just producing in recent years in addition, its mechanism of action is optionally to suppress calcium to enter cell, shrink to reduce venous,: the Chinese patent medicine of controlling headache of report has and does not just have ball at present, it is the Chinese medicine and western medicine side of closing, its mechanism is blood circulation promoting and blood stasis dispelling, and is furnished with the analgesic of Western medicine, and this medicine only is suitable for headache due to invasion of exogenous pathogens and so on.To the internal injury type of traditional Chinese medical science appellation headache blood deficiency and blood stasis headache due to hyperactivity of liver-YANG poor effect then.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine electuary for the treatment of headache can treat the headache due to internal injury category, adapt to angioneurotic headache.Migraine.And hypertensive dizziness, diseases such as headache.
Technical scheme of the present invention is a kind of Chinese medicine electuary for the treatment of headache, it is characterized in that its flavour of a drug constituent is:
Radix Angelicae Sinensis 4~9% Rhizoma Chuanxiong 4-9% Radix Paeoniae Alba 2-8% Radix Rehmanniae Preparata 2-8% Ramulus Uncariae Cum Unciss 10~15% Caulis Spatholobis 10~15% Spica Prunellae 10-15% Semen Cassiae 10-15% Concha Margaritifera 10-15% Rhizoma Corydalis 4-9% Herba Asaris 0.5~2%
The system of electuary of invigorating blood circulation clearly of this programme is sent technology and is: give before the medical material and handle a water and carry one and concentrate an ethanol precipitation one and reclaim ethanol one and be condensed into cream one mixing granulation one finished product packing.Promptly get above-mentioned each medicine in proportion.Decoct with water each one hour three times.Collecting decoction concentrates in right amount, adds the ethanol of 2 times of amounts, leaves standstill 24 hours precipitations, gets supernatant concentration and becomes cream, and relative density is a 1.3-1.4. paste-forming rate 10%, qinghuo reagent again, sucrose.Dextrin is dried into graininess by mixing at 1: 3: 1.
This prescription Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain belongs to treatment headache due to internal injury category, and Gai Yin " the brain being the reservoir of the marrow " mainly relies on liver, kidney.Essence and blood moistens supports and the transporting and transforming function of the spleen and stomach essence of water and grain, fills in brain on the defeated fear QI and blood, so headache due to internal injury and liver: spleen.Kidney three is dirty closely related.If the headache due to the blood deficiency and blood stasis, the ascension of deficiency of YIN liver-yang needs suitable nourshing blood and promoting blood circulation, nourishing yin and calming yang is a method.And be not report in this medicine at home.
Have concurrently to invigorate blood circulation among same 5 of this medicine is enriched blood and foster the spirit of nobility, have the YANG hyperactivity suppressing suppressing the hyperactive liver among the YIN nourishing replenishing essence concurrently, the motion in quiescence regulating yin and yang.It is invigorated blood circulation to be mainly and to nourish blood when being classified as monarch drug, pain relieving, and Radix Rehmanniae Preparata is a nourishing YIN and supplementing blood, beneficial essence is filled out marrow, because of " the brain being the reservoir of the marrow ".Marrow deficiency then brains is lost foster and had a pain, and is suitable with it.Is the Radix Paeoniae Alba the suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation? be used for positive blood deficiency and liver-yang high due to headache best.Rhizoma Chuanxiong blood-activating and qi-promoting, human blood divide the gas in the promoting the circulation of blood.The commonly used medicine of wind-expelling pain-stopping for having a headache due to the treatment blood stasis liver-yang, Radix Rehmanniae Preparata, the Radix Paeoniae Alba.Rhizoma Chuanxiong share the assistance monarch drug, and it act as nourshing blood and promoting blood circulation.Nourish yin and calm the liver, wind-expelling pain-stopping.Ramulus Uncariae Cum Uncis, Concha Margaritifera.Spica Prunellae.Semen Cassiae is a tranquillizing and allaying excitement, for benefit is controlled medicine.The promoting the circulation of blood of enriching blood of assistant association Caulis Spatholobi, relaxing muscles and tendons and activating QI and blood in the collateral, the pain relieving of Rhizoma Corydalis blood-activating and qi-promoting, Herba Asari fragrance is walked to scurry.The expelling wind and cold pain relieving is altogether for assistant makes, the total function in full side is the yin nourishing of enriching blood.Promoting blood circulation and stopping pain.
This medicine is except that curing mainly angioneurotic headache, migraine.Also can treat hypertensive dizziness headache.
This medicine is through clinical trial: use 1000 examples.Wherein male's 400 examples, women's 690 examples, 14~65 years old age, the course of disease 2 months-26 years, be headache or migraine, whole case history impassivity system exception signs, wherein the part patient all once obeyed medicines such as cafergot, gastrodine, somedon, its clinical observation result
Curative effect example number percentage rate
Cure 450 45%
Effective 100 10%
Produce effects 400 40%
Invalid 50 50%
Claims (2)
1, a kind of Chinese medicine electuary for the treatment of headache is characterized in that its flavour of a drug constituent is: Radix Angelicae Sinensis 4~9% Rhizoma Chuanxiong 4-9% Radix Paeoniae Alba 2-8% Radix Rehmanniae Preparata 2-8% Ramulus Uncariae Cum Unciss 10~15% Caulis Spatholobis 10~15% Spica Prunellae 10-15% Semen Cassiae 10-15% Concha Margaritifera 10-15% Rhizoma Corydalis 4-9% Herba Asaris 0.5~2%
2, the manufacture method of the Chinese medicine electuary of treatment according to claim 1 headache is characterized in that: the system of electuary of invigorating blood circulation clearly of this programme is sent technology and is: give before the medical material and handle a water and carry one and concentrate an ethanol precipitation one and reclaim ethanol one and be condensed into cream one mixing granulation one finished product packing.Promptly get above-mentioned each medicine in proportion.Decoct with water each one hour three times.Collecting decoction concentrates in right amount, adds the ethanol of 2 times of amounts, leaves standstill 24 hours precipitations, gets supernatant concentration and becomes cream, and relative density is 1.3-1.4.Paste-forming rate 10%, qinghuo reagent sucrose again.Dextrin is dried into graininess by mixing at 1: 3: 1.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA021486654A CN1500513A (en) | 2002-11-15 | 2002-11-15 | Instant traditional Chinese medicine formulation for headache |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA021486654A CN1500513A (en) | 2002-11-15 | 2002-11-15 | Instant traditional Chinese medicine formulation for headache |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1500513A true CN1500513A (en) | 2004-06-02 |
Family
ID=34233243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA021486654A Pending CN1500513A (en) | 2002-11-15 | 2002-11-15 | Instant traditional Chinese medicine formulation for headache |
Country Status (1)
Country | Link |
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CN (1) | CN1500513A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1318020C (en) * | 2004-06-25 | 2007-05-30 | 广东天之骄生命科技有限公司<Del/> | Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process |
CN100356938C (en) * | 2005-12-29 | 2007-12-26 | 颜怀伟 | Medicine and food dual purpose Chinese medicine for preventing and treating wind heat and headache and its manufacturing method |
CN1872216B (en) * | 2005-06-03 | 2011-07-13 | 天津天士力制药股份有限公司 | Medication composition for treating headache, and preparation method |
CN101194945B (en) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | Tablet for treating headache and method for preparing the same |
CN101194961B (en) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | Aerosol for treating headache and method for preparing the same |
CN101194965B (en) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | Mastication tablet for treating headache and method for preparing the same |
CN101194964B (en) * | 2006-12-08 | 2013-08-21 | 天士力制药集团股份有限公司 | Coated tablet for treating headache and method for preparing the same |
-
2002
- 2002-11-15 CN CNA021486654A patent/CN1500513A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1318020C (en) * | 2004-06-25 | 2007-05-30 | 广东天之骄生命科技有限公司<Del/> | Blood nourishing, brain refreshing orally disintegrating tablet and its preparation process |
CN1872216B (en) * | 2005-06-03 | 2011-07-13 | 天津天士力制药股份有限公司 | Medication composition for treating headache, and preparation method |
CN100356938C (en) * | 2005-12-29 | 2007-12-26 | 颜怀伟 | Medicine and food dual purpose Chinese medicine for preventing and treating wind heat and headache and its manufacturing method |
CN101194945B (en) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | Tablet for treating headache and method for preparing the same |
CN101194961B (en) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | Aerosol for treating headache and method for preparing the same |
CN101194965B (en) * | 2006-12-08 | 2013-06-05 | 天士力制药集团股份有限公司 | Mastication tablet for treating headache and method for preparing the same |
CN101194964B (en) * | 2006-12-08 | 2013-08-21 | 天士力制药集团股份有限公司 | Coated tablet for treating headache and method for preparing the same |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |