CN1134824A - Oral liquid for regulating women's sexual function - Google Patents
Oral liquid for regulating women's sexual function Download PDFInfo
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- CN1134824A CN1134824A CN 95104292 CN95104292A CN1134824A CN 1134824 A CN1134824 A CN 1134824A CN 95104292 CN95104292 CN 95104292 CN 95104292 A CN95104292 A CN 95104292A CN 1134824 A CN1134824 A CN 1134824A
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- oral liquid
- radix
- crude drug
- women
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- 239000007788 liquid Substances 0.000 title claims abstract description 18
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 8
- 230000036299 sexual function Effects 0.000 title claims description 11
- 241000005787 Cistanche Species 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 abstract description 5
- 210000004185 liver Anatomy 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 230000006870 function Effects 0.000 abstract description 3
- 206010016256 fatigue Diseases 0.000 abstract description 2
- 210000003127 knee Anatomy 0.000 abstract description 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 241000950640 Calcarius Species 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 244000241872 Lycium chinense Species 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 208000037093 Menstruation Disturbances Diseases 0.000 abstract 1
- 206010027339 Menstruation irregular Diseases 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 230000007778 menstrual function Effects 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 238000012795 verification Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 235000019202 steviosides Nutrition 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 241000605447 Anemarrhena Species 0.000 description 2
- 241001071795 Gentiana Species 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 241001078983 Tetradium ruticarpum Species 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010024419 Libido decreased Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000020694 gallbladder disease Diseases 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The composition of the invented oral liquid consists of prepared rehmannia root, saline cistanche, longspur epimedium, root of herbaceous peony, fruit of Chinese wolfberry, etc. traditional Chinese medicinal herbs. Indications: femal sexual involution, irregular menstruation, aching and limp waist and knee, lassitude and amnesia. Functions shown by pharmacolhogical verification and clinical trial are nourishing the blood, regulating the menstrual function, invigorating and tonifying the liver and kidney, strengthening yin and arresting convulision.
Description
The present invention relates to a kind of oral liquid of regulating women's sexual function, belong to health care medicine.
In recent years, along with the research and development of sex medicine, Chinese medicine and pharmacy has had some experiences to understanding and the treatment that women's sexual function goes down, as Li Yuyou to amenorrhea and the indifferent person of libido due to the obesity, control from stagnation of phlegm-damp, the cloudy depressed opinion of spleen, the side adds flavor (cognition of " the new traditional Chinese medical science in Tianjin " 1990,7,17 treatment amenorrheas) with the grey attached expectorant ball of leading, sombre for the women, Wang Wanzu is from the insufficiency of kidney-YANG diagnosis and treatment, with warm palace soup with disease adaptability in tactics (" the Sichuan traditional Chinese medical science " 1992,4.46. temperature palace soup treatment married woman is sombre); Zhang Chaojun then sombrely obtains effect with the treatment of self-control wine of sheep kidney; (treatment of " the Sichuan traditional Chinese medical science " 1995.5.37 wine of sheep kidney is sombre) Zheng Chunlei is to the sombre double bitter taste of seeing of women, costalgia person, examine and be dampness-heat in the liver and gallbladder disease, the side is sombre with Decoction of Gentiana for Purging the Liver-fire treatment) (treatment of " the Sichuan traditional Chinese medical science " 1990.1.42. Decoction of Gentiana for Purging the Liver-fire is sombre) bibliographic reference shows, being used for the treatment of women's sexual function now goes down, the menoxenia companion sees irritability, insomnia, lethargy, forgetful, many symptoms such as depression, the clinical doctor of polyphyly draws up prescription, the patient oneself decocts into decoction and takes, extremely inconvenient, in addition, these clinical reports of testing controlled are not all from the clear and definite side's medicine of experimental viewpoint mechanism of action with the pharmacodynamics data are provided.
The objective of the invention is to release a kind of fixed oral liquid formulation and go down to treat women's sexual function clinically, many symptoms of climacteric syndrome and association as a kind of pure Chinese medicine health-care medicine, guarantee the curative effect and the quality of medicine.
This health care medicine of the present invention is pure Chinese medicinal components, in order to regulate women's sexual function.Dosage form is an oral liquid, and its crude drug is formed and comprised (W/W)
Radix Rehmanniae Preparata 8-12%, Herba Cistanches 6-10%, Herba Epimedii 6-10%, Radix Paeoniae Alba 6-10%, Fructus Ligustri Lucidi 5-8%, Fructus Corni 5-8%, Fructus Lycii 5-8%, Caulis Spatholobi 5-8%, Radix Salviae Miltiorrhizae 3-6%, Radix Dipsaci 4-8%, Semen Ziziphi Spinosae (parched) 4-8%, Radix Angelicae Sinensis 5-8%, Cortex Phellodendri 5-8%, Rhizoma Anemarrhenae 5-8%, Cortex Moutan 3-6% Rhizoma Chuanxiong 2-5%.Oral liquid is the concentrated extract of above crude drug component.
The formulation method of this oral liquid comprises that the crude drug component is added moisture decocts filtration three times, merging filtrate is concentrated into relative density 1.0-1.2, adding 95% ethanol makes pure content reach 70%, fully stir evenly, left standstill 24 hours, filter, reclaim ethanol, add correctives, antiseptic, adding the ratio that entry makes crude drug and oral liquid is 1: 1.
The oral liquid of adjusting women's sexual function of the present invention is earlier with the nourishing blood for regulating menstruation, liver and kidney tonifying is attached most importance to, from the fixing Chinese medicine component Cheng Fang of dosage form, confirm through preclinical pharmacology, this oral liquid can significantly shorten rat incubation period emotionally, improve estradiol content in the teenage female Mus serum, improve the dispirited degree of going to ovum female mice uterus, increase adrenal gland's weight, certain calmness and resisting fatigue are also arranged, oxygen lack resistant function (seeing Appendix 1,2) clinical observation shows that oral liquid of the present invention has nourishing blood for regulating menstruation, the function of liver and kidney tonifying, nourishing YIN for tranquillization.Be applicable to women's deficiency of the liver and kindey, hyposexuality due to vim and vigour are uncomfortable, vaginal dryness, lethargy, have a dizzy spell, disease such as fidgety irritability, insomnia forgetfulness, soreness of the waist and knees, menoxenia, total effective rate is 93%, has the effect of paying of the obvious no any poison of effect (seeing Appendix 3) that improves women's sexual function and 9 sees Appendix 4,5) oral liquid of the present invention is significant to numerous women's psychosomatic health.
Below in conjunction with embodiment, describe technology contents of the present invention in detail.
1. female gentle liquid (trade name) prescription is formed:
The Radix Rehmanniae Preparata 90 gram Herba Cistanches 80 gram Herba Epimedii 80 gram Radix Paeoniae Alba 80 gram Fructus Ligustri Lucidi 60 Keshan Fructus Evodiaes 60 gram Fructus Lycii 60 gram Caulis Spatholobis 60 gram Radix Salviae Miltiorrhizaes 50 gram Radix Dipsacis 40 gram Semen Ziziphi Spinosae (parched)s 40 gram Radix Angelicae Sinensis 60 gram Cortex Phellodendris 80 gram Rhizoma Anemarrhenaes 80 gram Cortex Moutans 50 gram Rhizoma Chuanxiongs 30 gram sodium benzoate 3 gram steviosides are an amount of.
Above crude drug is decocted with water 3 times, add 10 times in water, decoct filtration in 2 hours for the 1st time; Add 8 times in water the 2nd time, decocted 1.5 hours, filter; Add 6 times in water the 3rd time, decocted 1 hour, and filtered, merging filtrate is concentrated into relative density 1.1-1.2, adding 95% ethanol makes and contains alcohol amount and reach 70%, fully stir evenly, leave standstill after 24 hours and filter recovery ethanol, add sodium benzoate, stevioside makes into the 1000ml heated and boiled with water, leaves standstill filtration, and packing promptly.
Embodiment 2, and female gentle liquid (trade name) prescription is formed
The Radix Rehmanniae Preparata 90 gram Herba Cistanches 80 gram Herba Epimedii 80 gram Radix Paeoniae Alba 80 gram Fructus Ligustri Lucidi 60 Keshan Fructus Evodiaes 60 gram Fructus Lycii 60 gram Caulis Spatholobis 60 gram Radix Salviae Miltiorrhizaes 50 gram Radix Dipsacis 40 gram Semen Ziziphi Spinosae (parched)s 40 gram Radix Angelicae Sinensis 60 gram Cortex Phellodendris 80 gram Rhizoma Anemarrhenaes 80 gram Cortex Moutans 50 gram Rhizoma Chuanxiongs 30 gram sodium benzoate 3 gram steviosides are an amount of.
Preparation method is with embodiment 1.
Claims (2)
1. its crude drug composition of oral liquid of regulating women's sexual function comprises (W/W)
Radix Rehmanniae Preparata 8-12%, Herba Cistanches 6-10%, Herba Epimedii 6-10%, Radix Paeoniae Alba 6-10%, Fructus Ligustri Lucidi 5-8%, Fructus Corni 5-8%, Fructus Lycii 5-8%, Caulis Spatholobi 5-8%, Radix Salviae Miltiorrhizae 3-6%, Radix Dipsaci 4-8%, Semen Ziziphi Spinosae (parched) 4-8%, Radix Angelicae Sinensis 5-8%, Cortex Phellodendri 5-8%, Rhizoma Anemarrhenae 5-8%, Cortex Moutan 3-6% Rhizoma Chuanxiong 2-5%.
Its oral liquid is the concentrated extract of above crude drug component.
2. a preparation method of regulating the oral liquid of women's sexual function comprises that the crude drug component is added moisture decocts filtration three times, merging filtrate is concentrated into relative density 1.0-1.2, adding 95% ethanol makes pure content reach 70%, fully stir evenly, left standstill 24 hours, filter, reclaim ethanol, add correctives, antiseptic, adding the ratio that entry makes crude drug and oral liquid is 1: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95104292A CN1048175C (en) | 1995-05-02 | 1995-05-02 | Oral liquid for regulating women's sexual function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95104292A CN1048175C (en) | 1995-05-02 | 1995-05-02 | Oral liquid for regulating women's sexual function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1134824A true CN1134824A (en) | 1996-11-06 |
| CN1048175C CN1048175C (en) | 2000-01-12 |
Family
ID=5075087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95104292A Expired - Fee Related CN1048175C (en) | 1995-05-02 | 1995-05-02 | Oral liquid for regulating women's sexual function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1048175C (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314437C (en) * | 2005-09-07 | 2007-05-09 | 高守坤 | Medicine for treating acute and chronic bronchial asthma and cough and its prepn |
| CN101375971B (en) * | 2008-09-27 | 2011-03-30 | 曹开镛 | Rejuvenating and yang-invigorating formulation for treating yin deficiency type impotence and preparation method thereof |
| CN101850016B (en) * | 2009-03-31 | 2012-02-22 | 江苏康缘药业股份有限公司 | Chinese medicinal composition for treating premature ovarian failure and preparation method thereof |
| CN102406838A (en) * | 2011-12-06 | 2012-04-11 | 赵英霖 | Traditional Chinese medicine for treating climacteric syndrome |
| CN102688372A (en) * | 2012-05-21 | 2012-09-26 | 何圣 | Skin care decoction for improving women sub-health, and preparation method thereof |
| CN103655966A (en) * | 2013-12-23 | 2014-03-26 | 青岛安信医疗器械有限公司 | Traditional Chinese medicine liquid for treating puerperal irregular menstruation |
| CN104173726A (en) * | 2014-08-28 | 2014-12-03 | 圣原健康产业有限公司 | Traditional Chinese medicine composition for postpartum recovery and preparation method and application of traditional Chinese medicine composition |
| CN105169076A (en) * | 2013-07-31 | 2015-12-23 | 朱保生 | Traditional Chinese medicine composition for treating irregular menstruation |
| CN106728649A (en) * | 2017-01-12 | 2017-05-31 | 张超英 | A kind of health pill for woman climacteric |
| CN107496875A (en) * | 2017-09-19 | 2017-12-22 | 袁贯丽 | A kind of Chinese medicine of QI invigorating |
| CN114681561A (en) * | 2022-04-24 | 2022-07-01 | 康芝药业股份有限公司 | Method for purifying active ingredients in Zhenlingdan mixture |
-
1995
- 1995-05-02 CN CN95104292A patent/CN1048175C/en not_active Expired - Fee Related
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314437C (en) * | 2005-09-07 | 2007-05-09 | 高守坤 | Medicine for treating acute and chronic bronchial asthma and cough and its prepn |
| CN101375971B (en) * | 2008-09-27 | 2011-03-30 | 曹开镛 | Rejuvenating and yang-invigorating formulation for treating yin deficiency type impotence and preparation method thereof |
| CN101850016B (en) * | 2009-03-31 | 2012-02-22 | 江苏康缘药业股份有限公司 | Chinese medicinal composition for treating premature ovarian failure and preparation method thereof |
| CN102406838B (en) * | 2011-12-06 | 2013-01-09 | 赵英霖 | Traditional Chinese medicine for treating menopausal syndrome |
| CN102406838A (en) * | 2011-12-06 | 2012-04-11 | 赵英霖 | Traditional Chinese medicine for treating climacteric syndrome |
| CN102688372B (en) * | 2012-05-21 | 2014-01-29 | 何圣 | Skin care decoction for improving women sub-health, and preparation method thereof |
| CN102688372A (en) * | 2012-05-21 | 2012-09-26 | 何圣 | Skin care decoction for improving women sub-health, and preparation method thereof |
| CN105169076A (en) * | 2013-07-31 | 2015-12-23 | 朱保生 | Traditional Chinese medicine composition for treating irregular menstruation |
| CN103655966A (en) * | 2013-12-23 | 2014-03-26 | 青岛安信医疗器械有限公司 | Traditional Chinese medicine liquid for treating puerperal irregular menstruation |
| CN104173726A (en) * | 2014-08-28 | 2014-12-03 | 圣原健康产业有限公司 | Traditional Chinese medicine composition for postpartum recovery and preparation method and application of traditional Chinese medicine composition |
| CN104173726B (en) * | 2014-08-28 | 2017-07-28 | 圣原健康产业有限公司 | Chinese medicine composition for postpartum recuperating and its preparation method and application |
| CN106728649A (en) * | 2017-01-12 | 2017-05-31 | 张超英 | A kind of health pill for woman climacteric |
| CN107496875A (en) * | 2017-09-19 | 2017-12-22 | 袁贯丽 | A kind of Chinese medicine of QI invigorating |
| CN114681561A (en) * | 2022-04-24 | 2022-07-01 | 康芝药业股份有限公司 | Method for purifying active ingredients in Zhenlingdan mixture |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1048175C (en) | 2000-01-12 |
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