CN101417086A - Traditional Chinese medicine preparation for treating myocardial ischemia - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating myocardial ischemia. The weight-to-number ratios of various components are as follows: 10-20 parts of Eucommia, 10-20 parts of notopterygium, 10-20 parts of kudzu root, 10-20 parts of salvia miltiorrhiza, and 10 parts of angelica ～20 parts, Gastrodia 10～20 parts, Astragalus 10～20 parts, Polygonum cuspidatum 10～20 parts, Centella asiatica 10～20 parts, Chuanxiong 10～20 parts, Poria cocos 10～20 parts, cinnamon 10～20 parts, Atractylodes macrocephala 10 parts ～20 parts, 10～20 parts of forsythia, 10～20 parts of Rehmannia glutinosa, 10～20 parts of Polygonum multiflorum, 10～20 parts of donkey-hide gelatin, 10～20 parts of licorice. The traditional Chinese medicine preparation for treating myocardial ischemia of the present invention is safe to use, non-toxic, verified by acute toxicity experiments, has no toxic and side effects, is suitable for patients with different constitutions, and can be taken for a long time; the traditional Chinese medicine preparation for treating myocardial ischemia of the present invention has no drug resistance, There are no dependent drug ingredients, so patients will not be dependent on long-term use.

Description

A kind of traditional Chinese medicine preparation for treating myocardial ischemia

technical field

The invention relates to a medical preparation containing raw materials derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating myocardial ischemia.

Background technique

Myocardial ischemic disease is a common disease, mostly in middle-aged and elderly people, and it is also the most common cause of temporary loss of working ability and premature disability of people with working ability. The basic symptoms are precordial discomfort, dull pain, palpitation, shortness of breath, chest tightness, fatigue and easy tiredness, muscle aches all over the body, and irregular heartbeat. Traditional Chinese medicine believes that the disease is related to heart blood loss, qi deficiency and blood stasis, and pathogenic heat disturbing the heart. About 500,000 people die from this disease every year in the United States, accounting for 1/3-1/2 of the number of patients, accounting for 50-70% of the number of deaths from heart disease. The incidence rate in our country is about 30%, accounting for more than 40% of the death toll, and increasing year by year, it has become the main cause of population death.

The incidence of myocardial ischemic disease increases with age, and the degree also increases with age. According to data, starting from the age of 40, the prevalence of myocardial ischemic diseases doubles for every 10 years of age. After the age of 50 for men and 60 for women, coronary arteriosclerosis develops rapidly, and the risk of myocardial infarction also increases with age.

At present, there are many drugs for the treatment of myocardial ischemic diseases, and the commonly used drugs are mainly chemical drugs, including nitrate preparations, adrenergic β receptor blockers (β blockers), calcium channel blockers, antiplatelet drugs, Adjust blood lipid drugs and anticoagulant drugs. Western medicine treatment often leads to some adverse reactions, such as inducing bronchial asthma, inhibiting the heart, and causing heart failure. There are also many kinds of Chinese patent medicines for the treatment of myocardial ischemic diseases. The more commonly used ones are Danshen preparations, compound ginkgo preparations, Suxiao Jiuxin pills, etc. These medicines have certain therapeutic effects, but there are certain problems, mainly due to different individual patients. The physique is not exactly the same, so the curative effect of the drugs during treatment is also not the same, and some even have no effect, and some of these drugs have certain drug resistance, and patients need to take the drugs for life, which affects the quality of life of patients.

Based on the above reasons, researching a safe, effective and rapid drug is an important task for the effective prevention and treatment of myocardial ischemic diseases. It is a very meaningful work to research and develop drugs for the prevention and treatment of myocardial ischemia with the characteristics of quick effect, definite curative effect, and small toxic and side effects, so as to reduce the threat of cardiovascular diseases to human health.

Contents of the invention

The technical problem to be solved by the present invention is to overcome the shortcomings in the current treatment of myocardial ischemia and provide a traditional Chinese medicine preparation for the treatment of myocardial ischemia which is easy to obtain materials, convenient to prepare, low in cost and high in cure rate.

In order to solve the above-mentioned technical problems, the present invention provides a traditional Chinese medicine preparation for treating myocardial ischemia. The weight-to-number ratios of various components are: Eucommia 10-20 parts, notopterygium 10-20 parts, kudzu root 10-20 parts, salvia miltiorrhiza 10 parts ～20 parts, Angelica 10～20 parts, Gastrodia elata 10～20 parts, Astragalus 10～20 parts, Polygonum cuspidatum 10～20 parts, Centella asiatica 10～20 parts, Chuanxiong 10～20 parts, Poria cocos 10～20 parts, cinnamon 10 parts ～20 parts, Atractylodes macrocephala 10～20 parts, Forsythia 10～20 parts, Rehmannia glutinosa 10～20 parts, Polygonum multiflorum 10～20 parts, Ejiao 10～20 parts, Licorice 10～20 parts.

For the traditional Chinese medicine preparation for treating myocardial ischemia, the weight-to-number ratio of various components can also be: 10-15 parts of Eucommia, 10-15 parts of Notopterygium, 10-15 parts of Pueraria Radix, 10-15 parts of Salvia Miltiorrhiza, 10-15 parts of Angelica Sinensis 10-15 parts of Tianma, 10-15 parts of Astragalus, 10-15 parts of Polygonum cuspidatum, 10-15 parts of Centella asiatica, 15-20 parts of Chuanxiong, 15-20 parts of Poria cocos, 15-20 parts of cinnamon, 15-20 parts of Atractylodes macrocephala 15-20 parts of forsythia, 15-20 parts of Rehmannia glutinosa, 15-20 parts of fleece-flower root, 15-20 parts of donkey-hide gelatin, and 15-20 parts of licorice.

The traditional Chinese medicine preparation for treating myocardial ischemia, the weight-to-number ratio of various components can be: Eucommia 15-20 parts, Notopterygium 15-20 parts, Pueraria 15-20 parts, Salvia miltiorrhiza 15-20 parts, Angelica sinensis 15-20 parts 15-20 parts of Tianma, 15-20 parts of Astragalus, 15-20 parts of Polygonum cuspidatum, 15-20 parts of Centella asiatica, 10-15 parts of Chuanxiong, 10-15 parts of Poria cocos, 10-15 parts of cinnamon, 10-15 parts of Atractylodes macrocephala 10-15 parts of forsythia, 10-15 parts of Rehmannia glutinosa, 10-15 parts of fleece-flower root, 10-15 parts of donkey-hide gelatin, and 10-15 parts of licorice.

In the traditional Chinese medicine preparation for treating myocardial ischemia, the weight-to-number ratio of various components may also be: 10-15 parts of Eucommia, 10-15 parts of Notopterygium, 10-15 parts of Pueraria Radix, 10-15 parts of Salvia Miltiorrhiza, 15-20 parts of Angelica Sinensis 15-20 parts of Tianma, 15-20 parts of Astragalus, 15-20 parts of Polygonum cuspidatum, 15-20 parts of Centella asiatica, 15-20 parts of Chuanxiong, 10-20 parts of Poria cocos, 10-20 parts of cinnamon, 10-20 parts of Atractylodes macrocephala 10-20 parts of forsythia, 10-15 parts of Rehmannia glutinosa, 10-15 parts of fleece-flower root, 10-15 parts of donkey-hide gelatin, and 10-15 parts of licorice.

The administration method of the traditional Chinese medicine preparation can be oral.

The dosage form of the traditional Chinese medicine preparation can be decoction, powder, honey-distilled pill, hydrated pill, tablet, capsule, oral liquid, granule or syrup.

The preparation of the powder of described Chinese medicine preparation can comprise the following steps:

Brush and wash the raw materials with water, remove and dry;

Put angelica, chuanxiong, poria, cinnamon, and rehmannia glutinosa into casserole and stir-fry for 5-10 minutes on low heat, grind them into fine powder with a grinder, and sieve;

Send the dried eucommia, notopterygium, kudzu root, salvia, gastrodia elata, forsythia, fleece-flower root, and donkey-hide gelatin into a slicer and cut into small slices, and then send the above-mentioned processed raw materials and other raw materials into a pulverizer to grind them into fine powder , sieved.

The sieve used for sieving the traditional Chinese medicine preparation for treating myocardial ischemia may be 90-100 mesh.

The traditional Chinese medicine preparation for treating myocardial ischemia can be pulverized in a pulverizer for 10-20 minutes.

The preparation of the powder of the traditional Chinese medicine preparation further includes the step of sterilizing the mixed fine powder by ultraviolet irradiation.

Compared with the prior art, the advantages of the present invention are: reasonable compatibility of the present invention, significant curative effect, quick effect, and high effective rate as proved by clinical experiments; the traditional Chinese medicine preparation for treating myocardial ischemia of the present invention is safe to use, non-toxic, and has been verified by acute toxicity experiments , no toxic side effects, suitable for patients with different constitutions, and can be taken for a long time; the traditional Chinese medicine preparation for the treatment of myocardial ischemia of the present invention has no drug resistance, is a traditional Chinese medicine preparation and has carefully selected materials, and has no dependent drug ingredients, so long-term use is also possible for patients. No dependencies will be created.

Detailed ways

Traditional Chinese medicine believes that chest pain and heartache can be caused by internal injuries of the seven emotions, fatigue from diet, tolerance of exogenous pathogens, deficiency of righteousness, etc. The heart governs the blood vessels, and if the blood vessels are blocked, heartache and death will occur; if the seven emotions are injured, qi stagnation and blood stasis will occur, and the heart collaterals will be blocked; Deficiency causes blood to flow, and blood stasis can also cause heartache. If the Qi movement is unfavorable, the chest will be suffocated and oppressed, and the breathing will be difficult; the heart governs the mind, the heart arteries will not flow smoothly, and the mind will be restless, so palpitations and palpitations will be seen. Although the causes of thoracic obstruction are different, internal stagnation of blood stasis, stagnation of qi, and disharmony of veins are the common pathological links of thoracic obstruction and heartache. Just as "Su Wen·The Essence of the Pulse" says: "The pulse is the home of blood, and astringent causes heartache." Therefore, the method of activating blood and promoting qi, dredging channels and relieving pain is widely used in the treatment of chest obstruction.

The present invention treats the Chinese medicine preparation of myocardial ischemia, and the effect of each taste medicine is:

Eucommia ulmoides: Treat waist and spine pain, flaccidity and weakness of limbs, nocturnal emission, slippery essence, diarrhea at dawn, asthenia, urination, dampness and itching in the genitals. Wang Haogu: "Liver Meridian Qi Division." "Lei Gong Pao Pharmacy Solution": "Enter the Kidney Channel." "Materia Medica Classic Explanation": "Start with the Taiyin Lung Channel." , to draw blood down. For soreness of the waist and knees, weakness of muscles and bones, amenorrhea in the abdomen, dizziness due to liver yang.

Notopterygium: expelling cold, relieving exterior syndrome, expelling rheumatism, relieving pain. Pungent and warm, qi is strong and dissipating, with strong expressive power. It mainly dispels the pathogenic wind and cold-damp in the sun meridian. It has the functions of dispelling cold and expelling wind, overcoming dampness and relieving pain. Those with no sweat, headache, strong neck, and sore limbs.

Radix Puerariae: relieves exterior syndrome and reduces fever, promotes fluid production, relieves rash, promotes yang and relieves diarrhea. For exogenous fever and headache, high blood pressure and neck pain, thirst, thirst, impervious measles, dysentery, and diarrhea. "Compendium of Materia Medica" contains: Radix Puerariae, cool in nature, flat in breath, sweet in taste, has the functions of clearing heat, reducing fire, and detoxifying. Modern medical research shows that puerarin, an isoflavone compound in kudzu root, has certain curative effects on hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular diseases.

Salvia miltiorrhiza: Salvia miltiorrhiza can promote the repair and regeneration of tissues. Salvia miltiorrhiza can promote the differentiation of fibroblasts, and the formation of collagen fibers is more obvious; the formation of granulation is more mature. Local congestion is reduced, blood circulation is improved, and healing time is shortened. Inhibition of hyperproliferation has an inhibitory effect on hyperproliferative fibroblasts.

Angelica: Enriches and activates blood circulation, regulates menstruation and relieves pain, laxes bowels. Curcuma breaks blood, promotes qi and relieves pain, and has a large warming force. It can treat abdominal pain, abdominal mass and accumulation due to stagnation of blood, eliminate stagnation and dissipate stagnation, promote qi, eliminate stagnation and relieve pain, break blood and remove blood stasis, promote qi and relieve pain.

Gastrodia elata: calming the liver, calming the wind and relieving convulsions. For headache and dizziness, limb numbness, limb paralysis, convulsions in children, epileptic convulsions, and tetanus.

Astragalus nourishes qi and promotes yang, stimulates sores and promotes granulation; it is used to warm and nourish the spleen and stomach to promote granulation, and it is used for insufficient qi and blood, sores and sores that are sunken for a long time; it strengthens the spleen and qi, and can regulate the immune function of the body.

Polygonum cuspidatum, slightly bitter, slightly cold. Return liver, gallbladder, lung meridian. Expelling wind and dampness, dissipating blood stasis and relieving pain, relieving cough and reducing phlegm. Used for arthralgia, damp-heat jaundice, amenorrhea, lump in the abdomen, water and fire burns, injuries from falls, carbuncles and sores, cough with excessive phlegm. "Compendium of Materia Medica": Indications of Polygonum cuspidatum, its circulation of blood seems to be similar to that of Tianming Jing, and its treatment of wind is similar to that of Wang Buliu Xing. The first Zhe said that it is the most detoxifying summer heat, and it is from the origin of blood biochemical to eliminate Condensation of heat, so the blood viscera of the Jueyin of the hand and the wind viscera of the Jueyin of the foot are cured like a drum. Prescriptions are used to treat convulsions, the same as all the heat-clearing flavors, and their functions are regarded as ear-piercing, but it is not used in other syndromes, why? The prescription is used to treat stranguria, that is, Danxi treats stranguria with injured Qi and blood of the elderly, and it is also regarded as an important medicine, which is used in tonics. Those who are said to be harmful to people who take it, go hand in hand with supplements, and the effect is almost the same.

Centella asiatica is bitter, pungent, and cold. Return liver, spleen, kidney channel. Clearing heat and promoting dampness, detoxification and detumescence. For damp-heat jaundice, heatstroke diarrhea, sandy drench with blood, carbuncle sores, and injuries from falls.

Rhizoma Chuanxiong is pungent, warm. Return liver, gallbladder, pericardium channel. Promoting blood circulation and promoting qi, expelling wind and relieving pain. Control wind-cold headache, dizziness, hypochondriac pain, abdominal pain, arthralgia due to cold, cramps, amenorrhea, dystocia, postpartum stasis block pain, carbuncle sore. For irregular menstruation, amenorrhea dysmenorrhea, abdominal pain in the abdomen, tingling pain in the chest and hypochondrium, tumbling and swelling pain, headache, rheumatic arthralgia. "Bie Lu": "In addition to the cold movement in the brain, the wind coming and going on the face, tears coming out of the eyes, excessive tears and saliva, sudden drunkenness, all kinds of cold air, hard pain in the heart and abdomen, evil in the heart, acute swelling and pain in the chest, wind pain in the flank, Warming the middle and internal cold." "Medicine Properties": "Treating weakness of the waist and feet, hemiplegia, prolapse of the main body clothes, and cold pain in the abdomen." "Nihuazi Materia Medica": "Cure all wind, all qi, all strain Blood, tonifies five fatigues, strengthens muscles and bones, adjusts multiple channels, breaks out stagnant blood, nourishes new blood, grows flesh, nasal flood, vomiting and drowning, hemorrhoids, fistula, back pain, scrofula, galls, sores and scabies, and Drain pus and eliminate blood stasis."

Poria cocos is sweet, flat, and light in nature, and has the functions of diuretic and dampness, invigorating the spleen, and calming the nerves. And it can promote the immune function of the human body; ether or ethanol extract can strengthen the contraction of the isolated frog heart, and increase the blood sugar of rabbits first and then reduce it. Poria decoction has a sedative effect on mice.

Cinnamon is very hot, spicy and sweet. Supplementing fire and supporting yang, drawing fire back to its source, dispelling cold and relieving pain, promoting blood circulation and stimulating menstruation. For impotence, uterine cold, confidant cold pain, deficiency-cold vomiting and diarrhea, amenorrhea, dysmenorrhea, warming meridians and dredging channels. "Supplements to Materia Medica": Guigui, Mugui, and Guixin have three colors and are the same thing. According to Guilin and Guiling, it is named after Guilin, and it is born today and does not leave this county. From the south of the ridge to the sea, there are all osmanthus trees, but willows and Xiangzhou are the most numerous. The taste is pungent, and the skin is thick and firm. If it is thick, it will be tender, and if it is thin, it will be old. The old and thin ones are the same color, and the thick and tender ones are the same color. Tenderness is spicy, and it is also rolled; old must be light, and naturally thin. The thin ones are Mu Gui Ye, which is named after the big ones; the rolled ones are the Kui Gui Ye, which are tender and easy to roll. In ancient times, there was Tonggui, whose characters resembled the characters of 箘. Later generations wrote it by mistake, and it became a custom after habit. As for the transmission of books, they followed suit. Guixin is to peel off the nails on the skin, and take the inner part, which is pungent and flavorful.

Atractylodes macrocephala is bitter, sweet, salty, and cold in nature, and has the functions of clearing heat, detoxifying, and nourishing yin. Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizome has the effect of invigorating the spleen and replenishing qi, drying dampness and promoting diuresis, antiperspirant and preventing miscarriage. For insufficiency of the spleen, lack of food, abdominal distension and diarrhea, dizziness and palpitation due to phlegm and retention, edema, spontaneous sweating, restless fetal movement. "Medical Genesis" records: "Remove dampness and benefit dryness, harmonize the middle and replenish qi, warm the middle, remove dampness in the spleen and stomach, remove stomach heat, strengthen the spleen and stomach, eat food, quench thirst, and prevent pregnancy."

Forsythia bitter, slightly cold. Return lung, heart, small intestine channel. Heat-clearing and toxic substances removing, reducing swelling and dissipating stagnation. For carbuncle, scrofula, breast carbuncle, erysipelas, wind-heat cold, febrile disease at the onset, warm-heat enters the camp, high fever and polydipsia, coma and spots, heat-drenched urine retention. The medicinal part of forsythia is mainly the fruit. Its husk is the "Qiao" in "Lingqiao Jiedu Pills". Contains forsythol, coumarin, oleanolic acid, saponins, vitamin P, etc. It has the effects of clearing away heat, detoxifying, dispelling stagnation and draining pus. Indications for fever, sores, scrofula, erysipelas, rash, influenza.

Rehmannia glutinosa is sweet in taste and slightly warm in nature. Return liver, kidney channel. It has the effect of nourishing blood and nourishing yin. For blood deficiency and chlorosis, dizziness, palpitation, insomnia, irregular menstruation, metrorrhagia embolism. It can be used for hot flashes, night sweats, nocturnal emission, diabetes, etc. due to deficiency of kidney yin; it can be used for soreness of waist and knees, dizziness, tinnitus, premature graying of beard and hair, etc. due to deficiency of liver and kidney essence and blood.

Polygonum multiflorum is bitter, sweet, astringent, warm. Return liver, heart, kidney channel. Detoxifcation, disappear carbuncle, laxative. For scrofula carbuncle, rubella pruritus, intestinal dryness and constipation; hyperlipidemia. Modern medical research shows that Polygonum multiflorum has the function of enhancing immunity. Polygonum multiflorum has obvious antagonism to the inhibitory changes in the spleen and thymus of aged mice induced by prednisolone and cyclophosphamide, and significantly increases the phagocytic rate and phagocytic index of spleen macrophages. Feeding Shouwu ethanol extract can significantly improve the DNA damage repair ability of peripheral lymphocytes in aged rats. Mice fed Shouwu 6g/kg for 7 consecutive days, which can significantly improve the phagocytic ability of peritoneal macrophages, and has obvious antagonism to the decrease of phagocytic index caused by prednisolone. The alcohol extract of Polygonum multiflorum decocted in water can enhance the immune function of T lymphocytes and B lymphocytes in mice, and the effect of the former is more significant. Polygonum multiflorum extract 25-100mg/kg, intraperitoneal injection, continuous administration for 3 days, can significantly improve the proliferation of thymus and spleen T lymphocytes induced by ConA in normal mice; subcutaneous injection of 5-100g/kg, continuous 3 days, can Significantly increase the number of antibody-forming cells in the spleen of normal mice, and the effect is most significant in the 50g/kg group.

Donkey-hide gelatin sweet, flat. "Ben Jing": "Taste sweet, flat." "Bie Lu": "Temperature, non-toxic." through. Nourish yin and enrich blood, prevent miscarriage. Control blood deficiency, consumptive cough, vomiting blood, epistaxis, blood in stool, irregular menstruation in women, metrorrhagia, fetal leakage. "The Classic": "The main confidant is collapsed, the fatigue is like a malaria, the waist and abdomen pain, the limbs are sore, and the woman is bleeding. Anti-fertility. Long-term use to replenish Qi." "Bie Lu": "The husband has lower abdomen pain, fatigue Lean and thin, lack of yin qi, sore feet can not stand for a long time, nourish liver qi." "On the Properties of Medicine": "Maintains strengthening muscles and bones, nourishing qi and stopping dysentery." "Qian Jin · Food Treatment": "Treating strong wind."

Licorice Gan, flat. GUIXIN, lung, spleen, stomach warp. Invigorating the spleen and replenishing qi, clearing away heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines. For weakness of the spleen and stomach, lassitude and weakness, palpitation and shortness of breath, cough with copious phlegm, epigastric abdomen, extremity convulsion acute pain, carbuncle sore tumefacting virus, alleviates drug toxicity, strong. Licorice is sweet in nature and flavor, flat. Heart, lung, spleen, stomach meridian. Used as a medicine, it can purify fire and detoxify, moisten the lungs, eliminate phlegm and relieve cough, replenish qi and invigorate the middle, relieve spasms and relieve pain, and alleviate the properties of the medicine. acute pain embolism. The medicinal properties of licorice are moderate and can be increased or decreased. It can be used in conjunction with various medicines such as tonics, laxatives, cold medicines, warm medicines, and cold medicines, and has the effect of reconciling the medicinal properties. Western medicine has found that licorice has anti-inflammatory and anti-allergic functions, so it is mainly used as a palliative in Western medicine. Relieve cough, eliminate phlegm, and treat sore throat and laryngitis; licorice or glycyrrhetinic acid has the effect of deoxycorticosterone, which has a good effect on chronic adrenal insufficiency; Lifespan, has anti-inflammatory activity, and is often used in the treatment of chronic ulcers and duodenal ulcers; the flavonoids of licorice have anti-inflammatory, antispasmodic and antacid effects.

Myocardial ischemic diseases mostly occur in middle-aged and elderly people over the age of 40. After middle age, the righteousness gradually declines, and the medicines for promoting blood circulation and promoting Qi tend to break down in nature, so it is easy to damage the righteousness. , it can not only strengthen the body to get rid of the evil, but also get rid of the evil without hurting the body, which complement each other. Qi stagnation and blood stasis of chest obstruction, is the intersection of blood stagnation and Qi stagnation. Qi is handsome and blood moves, and stagnation of qi leads to blood stasis; when blood stasis is blocked, the movement of qi is not smooth. Blood stasis and qi stagnation block the heart vessels, and qi and blood are blocked, so death is painful. Aiming at the above pathogenesis, the main function of this prescription is to promote qi and blood circulation. Equal emphasis is placed on promoting qi and promoting blood circulation, and the compatibility is strict. Expelling evil and strengthening the body are applied together, and they play the role of regulating qi and removing blood stasis, replenishing qi and blood, and regulating the spleen and stomach.

The Chinese medicinal preparation for the treatment of myocardial ischemia of the present invention prepares the medicine of powder formulation according to the following method:

Brush and wash the raw materials with water, remove and dry;

Put angelica, chuanxiong, poria, cinnamon, and rehmannia glutinosa into casserole and stir-fry on low heat for 5-10 minutes, grind them with a grinder for 10 minutes, wait until they are fine, and sieve through a 100-mesh sieve;

Send the dried eucommia, notopterygium, kudzu root, salvia, gastrodia elata, forsythia, fleece-flower root, and donkey-hide gelatin into a slicer and cut into small slices, and then send the above-mentioned treated raw materials and other raw materials into a pulverizer for crushing for 20 minutes. After it becomes fine powder, it is sieved with 90 meshes, and the fine powder after sieving is sterilized by ultraviolet irradiation, and then subpackaged for use.

Pharmacodynamics experiment:

The protective effect of the drug on the ability of mice to withstand hypoxia: 120 test mice, male, each group was randomly divided into normal pressure, normal pressure+ISO and low pressure for testing under three conditions after the last administration of the animals. Show that this medicine treats 8 days, can obviously enhance the hypoxia tolerance ability of mice.

Effect on myocardial ischemia induced by pituitrin: animal experiments showed that the blood pressure, heart rate and electrocardiogram positive detection rate before and after ischemia showed that the drug can significantly resist myocardial ischemia caused by pituitrin symptom. The change of serum lactate dehydrogenase isoenzyme caused by vasopressin showed obvious protective effect on the myocardium.

Effects on rat serum total cholesterol and platelet aggregation and adhesion function: Animal experiments have shown that it can significantly reduce serum and liver cholesterol levels, and can significantly improve platelet aggregation and adhesion functions.

Effects on the stress ability of mice: 64 rats were randomly divided into groups and treated for 6 days. Except for the normal group, the other groups were established as animal models of blood stasis. The specific viscosity of whole blood, plasma specific viscosity, red blood cell Packing percentage, red blood cell aggregation index and other indicators. The results showed that the drug had a significant improvement effect on the high shear rate, low shear rate, RBC accumulation index and plasma specific viscosity of rats with blood stasis compared with the control.

Effects on cardiac function and hemodynamics in rats: It can significantly increase CO and CI of normal rats, and a small dose of the drug can still increase LVSP, which is significant within 35 minutes. It has no significant effect on other cardiac function and hemodynamic indicators.

Effects on ischemic myocardium function, metabolism and morphology:

1. The effect of the drug on cardiac function and hemodynamics in ischemic rats: Experiments have shown that the mean arterial pressure, Lvsp, -dp/atmax, CO, CI and so on were significantly reduced, but the drug could increase the mean arterial pressure after MI, LVSP, +dp/dtmax, CO, CI and so on, especially in the small dose group.

2. The influence on the morphological changes of acute ischemic myocardium: From the results of microscopic examination, it can be seen that all infarction and infarction intervention groups had focal myocardial infarction; 9/10 cases in the MI group, 2/8 cases in the low-dose group, and 2/8 cases in the high-dose group The group was 5/11 cases, and the positive control group was 6/11 cases, indicating that the Chinese medicine preparation of the present invention has the effect of alleviating myocardial necrosis.

Typical case 1: Ms. Zhang, 48 years old, has been ill for 5 years, with chest tightness, shortness of breath, chest pain, insomnia, dizziness, palpitations, fatigue, dark tongue with greasy coating, deep thready pulse. Use the following recipe:

Eucommia 10g, Notopterygium 10g, Pueraria 10g, Salvia 10g, Angelica 10g, Gastrodia elata 10g, Astragalus 10g, Polygonum cuspidatum 10g, Centella asiatica 10g, Chuanxiong 10g, Poria 10g, Cinnamon 10g, Atractylodes macrocephala 10g, Forsythia 10g, Rehmannia glutinosa 10g, Polygonum multiflorum 10g , donkey-hide gelatin 10g, licorice 10g.

After taking 35 doses of Chinese medicine decoction of the present invention, the symptoms are obviously alleviated, and there is no recurrence so far.

Typical case 2: Ms. Wang, 53 years old, the patient reported that in the past few months, she felt stuffy in her chest, her heart beat sometimes violently, her left chest was stabbed, and sometimes her back was painful, her fur was dark and her pulse was stringy, and the syndrome was heart blood stasis. resistance. Use the following recipe:

Eucommia 10g, Notopterygium 10g, Pueraria 10g, Salvia 10g, Angelica 10g, Gastrodia elata 10g, Astragalus 10g, Polygonum cuspidatum 10g, Centella asiatica 10g, Chuanxiong 15g, Poria 15g, Cinnamon 15g, Atractylodes macrocephala 15g, Forsythia 15g, Rehmannia glutinosa 15g, Polygonum multiflorum 15g , donkey-hide gelatin 15g, licorice 15g.

Adopt Chinese medicine decoction for oral administration of the present invention, take 20 doses first, the symptom obviously takes a turn for the better, then take 20 doses again, the symptoms such as heart feeling stuffy and left chest tingling disappear substantially. Follow-up visit after 6 months, no recurrence.

Typical case 3, Mr. Zhao, 63 years old, began to suffer from coronary heart disease three years ago. The symptoms were coronary heart disease, asthma, chest tightness and suffocation, persistent pain, sometimes reflected to the back, cold limbs, fatigue, and repeated attacks. Use the following recipe:

Eucommia 15g, Notopterygium 15g, Pueraria 15g, Salvia 15g, Angelica 15g, Gastrodia elata 15g, Astragalus 15g, Polygonum cuspidatum 15g, Centella asiatica 15g, Chuanxiong 10g, Poria 10g, Cinnamon 10g, Atractylodes macrocephala 10g, Forsythia 10g, Rehmannia glutinosa 10g, Polygonum multiflorum 10g , donkey-hide gelatin 10g, licorice 10g.

After taking 40 doses of Chinese medicine decoction of the present invention, the symptoms obviously alleviated, and then took the Chinese medicine powder of the present invention for 1 month to consolidate the curative effect, so far no recurrence in four years.

Typical case 4: Leng male, 61 years old, with a history of angina pectoris of coronary heart disease for two years, frequent attacks in the past month, 3 to 5 times a week, each time lasting about 5 to 6 minutes, chest pain, palpitations, chest tightness and shortness of breath when moving, Dysphoria and restlessness can be relieved by self-administration of "Compound Danshen Dripping Pills". The clinical diagnosis is coronary heart disease angina pectoris, which belongs to the syndrome of blood stasis and heat in the heart vessels. Use the following recipe:

Eucommia 10g, Notopterygium 10g, Pueraria 10g, Salvia 10g, Angelica 15g, Gastrodia elata 15g, Astragalus 15g, Polygonum cuspidatum 15g, Centella asiatica 15g, Chuanxiong 15g, Poria cocos 10g, Cinnamon 10g, Atractylodes macrocephala 10g, Forsythia 10g, Rehmannia glutinosa 10g, Polygonum multiflorum 10g , donkey-hide gelatin 10g, licorice 10g.

After taking 40 doses of Chinese medicine powder of the present invention, after the treatment, the electrocardiogram V4-6ST segment was rechecked, and the T wave was relatively upright and flat, and adverse reactions did not occur in the treatment process.

The formulas of the above examples are typical formulas used by the inventor according to the illness and physical conditions of different patients. After preparation, they are brewed into powders, pills, or decoctions. Generally, 2 doses are taken for 3 days, and they are taken after meals. After one course of treatment, 90 patients with coronary heart disease (including angina pectoris and myocardial infarction) were tested and observed. Satisfactory results were obtained in 2-4 courses of treatment. According to the clinical efficacy observation, the effective rate reached 88.9%, and there was basically no recurrence after follow-up.

Claims (10)

1, a kind of Chinese medicine preparation for the treatment of myocardial ischemia, it is characterized in that the ratio of weight and number of various compositions is: 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Radix Puerariaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts in Rhizoma Gastrodiae, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Herba Centellaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts in Poria, 10～20 parts of Cortex Cinnamomis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Forsythiaes, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Polygoni Multiflori, 10～20 parts in Colla Corii Asini, 10～20 parts in Radix Glycyrrhizae.

2, according to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 10～15 parts of the Cortexs Eucommiae, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts in Rhizoma Gastrodiae, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Herba Centellaes, 15～20 parts of Rhizoma Chuanxiongs, 15～20 parts in Poria, 15～20 parts of Cortex Cinnamomis, 15～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Fructus Forsythiaes, 15～20 parts in Radix Rehmanniae Preparata, 15～20 parts of Radix Polygoni Multiflori, 15～20 parts in Colla Corii Asini, 15～20 parts in Radix Glycyrrhizae.

3, according to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 15～20 parts of the Cortexs Eucommiae, 15～20 parts of Rhizoma Et Radix Notopterygiis, 15～20 parts of Radix Puerariaes, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts in Rhizoma Gastrodiae, 15～20 parts of the Radixs Astragali, 15～20 parts of Rhizoma Polygoni Cuspidati, 15～20 parts of Herba Centellaes, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts in Poria, 10～15 parts of Cortex Cinnamomis, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Forsythiaes, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts in Colla Corii Asini, 10～15 parts in Radix Glycyrrhizae.

4, according to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 10～15 parts of the Cortexs Eucommiae, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts in Rhizoma Gastrodiae, 15～20 parts of the Radixs Astragali, 15～20 parts of Rhizoma Polygoni Cuspidati, 15～20 parts of Herba Centellaes, 15～20 parts of Rhizoma Chuanxiongs, 10～20 parts in Poria, 10～20 parts of Cortex Cinnamomis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Forsythiaes, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts in Colla Corii Asini, 10～15 parts in Radix Glycyrrhizae.

According to the Chinese medicine preparation of each described treatment myocardial ischemia in the claim 1～4, it is characterized in that 5, the administering mode of described Chinese medicine preparation is oral.

According to the Chinese medicine preparation of each described treatment myocardial ischemia in the claim 1～4, it is characterized in that 6, described Chinese medicine preparation dosage form is decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule or syrup.

According to the Chinese medicine preparation of each described treatment myocardial ischemia in the claim 1～4, it is characterized in that 7, the preparation of the powder of described Chinese medicine preparation may further comprise the steps:

With described raw material water brush, wash clean, pull out and dry;

Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5～10 minutes, respectively it is ground into smalls, sieve with pulverizer;

The Cortex Eucommiae after will drying, Rhizoma Et Radix Notopterygii, Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Fructus Forsythiae, Radix Polygoni Multiflori, Colla Corii Asini are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.

According to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 7, it is characterized in that 8, the used sieve that sieves is 90～100 orders.

According to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 7, it is characterized in that 9, the time of pulverizing is 10～20 minutes in pulverizer.

According to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 7, it is characterized in that 10, the preparation of the powder of described Chinese medicine preparation further comprises the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.