CN105213905A - A kind of Chinese medicine composition and application thereof preventing and treating postmenopausal osteoporosis - Google Patents

Abstract

A traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis. The raw materials of the traditional Chinese medicine composition are Radix Paeoniae Alba, Radix Nocturna, Epimedium, Ligustrum lucidum, Cuscuta, Polygonum cuspidatum, Red Ginseng, Eclipta chinensis, Red Ginseng Sedum, rubbing white leaves, cistanche, eucommia, medlar, Cracker, Milletah, Sangji, Zhishouwu, Agrimony, safflower, Gentiana, Ziheche, Sanleng, snow lotus, dried blood, motherwort , Panax notoginseng, kudzu root, Morinda officinalis, Gastrodia elata, black sesame. The selected medicinal materials of the Chinese medicine composition of the present invention are suitable for compatibility, which conforms to the theory of traditional Chinese medicine and modern medicine, and its compatibility conforms to the principle of "junchenzuoshi" of traditional Chinese medicine, and has a unique curative effect on postmenopausal osteoporosis. The medicine is scientifically compatible, and the curative effect is rapid and effective Fast, short course of treatment, high cure rate, low cost advantages.

Description

A traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis and its application

technical field

The invention belongs to the technical field of medicine and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis and its application.

Background technique

Osteoporosis is a systemic bone disease characterized by decreased bone mass and destruction of bone microstructure, resulting in increased bone fragility and easy fractures. Osteoporosis can be divided into three major categories: primary osteoporosis, secondary osteoporosis, and idiopathic osteoporosis. The first type of primary osteoporosis can be divided into postmenopausal women's osteoporosis (type I) and senile osteoporosis (type II); the second type is secondary osteoporosis, which Osteoporosis induced by other diseases (such as renal failure, excessive thyroid hormone or leukemia), or drugs (such as steroids); the third type is idiopathic osteoporosis, which is more common in 8-14 years old Adolescents or adults over 100 years old mostly have a family history of inheritance, and more women than men. Osteoporosis that occurs during pregnancy and lactation in women can also be classified as idiopathic osteoporosis.

Osteoporosis is a common and frequently-occurring disease of middle-aged and elderly people, which seriously affects the health and quality of life of this group of people. Osteoporosis and the fractures it causes rank seventh among the current common diseases, seriously threatening The health of the elderly makes it a global public health problem. At present, the aging of the population is becoming more and more serious, and it is of great significance to improve the awareness of prevention and treatment of osteoporosis. Osteoporosis is characterized by decreased bone mass, including the reduction in the proportion of bone mineral and matrix, and the degradation of the microstructure of bone tissue. A systemic skeletal disease in which the mechanical strength of the bone decreases, the load bearing capacity decreases, and microfractures or complete fractures are prone to occur. Clinically, the main symptoms of osteoporosis patients are low back pain, hunchback, and easy fractures, often accompanied by kidney deficiency symptoms, such as low back pain, loss of libido, etc., which seriously affect the quality of life and life. According to United Nations statistics, aging has become an irreversible worldwide trend in the 21st century. China has entered an aging society in 1999. The aging rate of Chinese society is faster than the growth rate of the total population of the country. According to incomplete statistics, the incidence of osteoporosis in the elderly over 60 years old in my country is about 59.89%. Therefore, increasing bone density and effectively treating osteoporosis have become people's important topic of widespread concern.

At the 2004 World Osteoporosis Congress of the International Osteoporosis Foundation (IOF), Johnell et al., the WHO Metabolic Bone Disease Research Center at the University of Sheffield, UK, analyzed 12 clinical studies, which included 3 of the 12 population studies. Ten thousand and nine thousand people. It was found that the lower the BMD value, the higher the probability of osteoporotic fractures (and all types of fractures), and this pattern was most pronounced in the 65-year-old age group. The full name of bone mineral density (BMD) is bone mineral density, which is an important indicator of bone strength, and 75% to 85% of the strength of bone tissue is related to bone density. Bone density refers to the bone density per unit area of bone, which refers to the tightness of bone tissue integration, and usually refers to the bone mineral content. It is an objective and quantitative index to measure osteoporosis at present, and it is also an index to reflect bone mass. Its unit is g/c㎡. The higher the bone density, the better the bone strength. It is related to bone structure, bone mass, bone mineral content and other factors.

Modern medicine believes that postmenopausal osteoporosis is a common disease related to aging, which mainly occurs in postmenopausal women. Due to estrogen deficiency, bone mass decreases and bone tissue structure changes, resulting in increased bone fragility and easy fractures, and Pain, bone deformation, complications, and even death caused by fractures seriously affect the health and quality of life of the elderly, and even shorten life expectancy, increasing the financial and human burden of the country and families. Osteoporosis is a common disease in postmenopausal women. It is a frequently occurring disease and its harm is becoming more and more serious. It is called a "silent epidemic" and has attracted worldwide attention. The clinical manifestations are as follows: back pain at the earliest, followed by vertebral body compression, accompanied by spinal deformity, hunchback becoming shorter, etc. In severe cases, it can cause thoracic deformity, affect lung function, and fracture concurrently. Increased risk. At present, Western medicine treatment methods for this disease mostly use estrogen supplementation, calcium and vitamins, but long-term use of large amounts of estrogen may cause side effects such as endometrial cancer and breast cancer, and the supplementation of calcium and vitamins is difficult to control in terms of dosage. .

At present, osteoporosis associated with menopause has become an important health care issue that cannot be ignored. Postmenopausal osteoporosis is a multifactorial disease, and heredity, lifestyle, and nutrition are all related to the disease. Postmenopausal osteoporosis is predisposed to developing postmenopausal osteoporosis in people who have the following risk factors: Caucasian and Asian women, women with a family history of osteoporosis or women with specific genes that affect bone mass, insufficient calcium intake, physical inactivity, heavy smoking, and alcohol consumption , Early menopause or premenopausal bilateral oophorectomy. Whether osteoporosis occurs depends on the peak bone mass and the speed of bone loss. Those with high peak bone mass and/or slow bone loss are less likely to develop, while those with low peak bone mass and/or fast bone loss are more likely to develop.

Depending on the cause and mechanism of bone mineral density deficiency, different methods can be chosen to increase bone density. At present, calcium, active vitamin D, sex hormones, calcitonin, bisphosphonates and fluoride are often used in clinical treatment. Certain curative effect, but side effect is big, and expense is expensive, and cures the symptoms but not the root cause. In terms of treatment, Western medicine still lacks effective measures, and the application of drugs is also very limited. Simple calcium supplementation can only delay but not prevent the loss of bone mass. Therefore, research and development of a drug that effectively supplements the lost calcium and can consolidate and prevent bone loss, is safe and has no side effects, so as to fundamentally solve the problem of osteoporosis has become an urgent problem to be solved.

Contents of the invention

The purpose of the present invention is to solve the shortcomings of the above-mentioned prior art, and provide a traditional Chinese medicine composition that can effectively prevent and treat postmenopausal osteoporosis, has quick effect, short course of treatment and high cure rate.

Above-mentioned purpose of the present invention is achieved by following technical scheme:

A traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis. The raw materials of the traditional Chinese medicine composition are Radix Paeoniae Alba, Radix Nocturna, Epimedium, Ligustrum lucidum, Cuscuta, Polygonum cuspidatum, Red Ginseng, Eclipta chinensis, Red Ginseng Sedum, rubbing white leaves, cistanche, eucommia, medlar, Cracker, Milletah, Sangji, Zhishouwu, Agrimony, safflower, Gentiana, Ziheche, Sanleng, snow lotus, dried blood, motherwort , Panax notoginseng, kudzu root, Morinda officinalis, Gastrodia elata, black sesame.

Further, the composition and parts by weight of the raw materials for making the traditional Chinese medicine composition are: 12-20 parts of Radix Paeoniae Alba, 10-16 parts of Epimedium, 3-8 parts of Ligustrum lucidum, 5-12 parts of Cuscuta, 12-17 parts of rattan, 7-12 parts of red ginseng, 4-9 parts of safflower, 15-20 parts of Eclipta, 10-15 parts of rhodiola, 8-12 parts of white leaves, 2-5 parts of Cistanche, 3-7 parts of Lycium barbarum, 11-14 parts of Caulis Spatholobus, 9-15 parts of Gufengfeng, 3-6 parts of Sangjisheng, 8-13 parts of Shouwu, 3-5 parts of Snow Lotus, 1-3 parts of Eucommia, Agrimony 5-10 parts, Panax notoginseng 5-10 parts, Polygonum cuspidatum 13-16 parts, Gentiana chinensis 3-10 parts, Ziheche 8-13 parts, Sanleng 3-5 parts, dried blood 1-3 parts, Pueraria 5 parts -10 parts, Motherwort 3-6 parts, Morinda officinalis 8-13 parts, Gastrodia elata 3-5 parts, black sesame 13-16 parts.

Further, the composition and parts by weight of the raw materials for making the Chinese medicine composition are: 12 parts of Radix Paeoniae Alba, 16 parts of Epimedium, 3 parts of Ligustrum lucidum, 12 parts of Cuscuta chinensis, 12 parts of Caulis japonica, and 10 parts of red ginseng , 9 parts of safflower, 15 parts of Eclipta, 15 parts of Rhodiola rosea, 8 parts of white leaves, 5 parts of Cistanche, 3 parts of medlar, 14 parts of Caulis Spatholobus, 9 parts of Cereal, 6 parts of Sangji, 8 parts of Shouwu, 5 parts of Snow Lotus, 1 part of Eucommia, 10 parts of Agrimony, 5 parts of Panax notoginseng, 16 parts of Polygonum cuspidatum, 10 parts of Gentiana chinensis, 8 parts of Ziheche, 5 parts of Sanleng, 1 part of blood jellyfish, and 10 parts of kudzu root 6 parts of Motherwort, 8 parts of Morinda officinalis, 3 parts of Gastrodia elata, and 13 parts of black sesame.

Further, the composition and parts by weight of the raw materials for making the Chinese medicine composition are: 20 parts of Radix Paeoniae Alba, 10 parts of Epimedium, 8 parts of Ligustrum lucidum, 5 parts of Cuscuta chinensis, 17 parts of Caulis japonica, 12 parts of red ginseng , 4 parts of safflower, 20 parts of Eclipta, 10 parts of Rhodiola rosea, 12 parts of white leaves, 2 parts of Cistanche, 7 parts of medlar, 11 parts of Caulis Spatholobus, 15 parts of Cragonia, 3 parts of Mulberry, 13 parts of Shouwu, 3 parts of Snow Lotus, 3 parts of Eucommia, 5 parts of Agrimony, 10 parts of Panax notoginseng, 13 parts of Polygonum cuspidatum, 3 parts of Gentiana, 13 parts of Ziheche, 3 parts of Sanleng, 3 parts of blood, and 5 parts of Pueraria 4 parts of Motherwort, 10 parts of Morinda officinalis, 4 parts of Gastrodia elata, 16 parts of black sesame.

Further, the composition and parts by weight of the raw materials for making the Chinese medicine composition are: 13 parts of Radix Paeoniae Alba, 11 parts of Epimedium, 4 parts of Ligustrum lucidum, 6 parts of Cuscuta chinensis, 13 parts of Caulis japonica, and 7 parts of red ginseng , 5 parts of safflower, 18 parts of Eclipta, 11 parts of Rhodiola, 9 parts of white leaves, 4 parts of Cistanche, 6 parts of medlar, 12 parts of Milletah, 13 parts of Rhizoma, 4 parts of Mulberry, 9 parts of Shouwu, 4 parts of Snow Lotus, 2 parts of Eucommia, 6 parts of Agrimony, 6 parts of Panax notoginseng, 14 parts of Polygonum cuspidatum, 5 parts of Gentiana chinensis, 10 parts of Ziheche, 4 parts of Sanleng, 2 parts of blood, 6 parts of Pueraria 5 parts of Motherwort, 12 parts of Morinda officinalis, 3 parts of Gastrodia elata, and 14 parts of black sesame.

Further, the composition and parts by weight of the raw materials for making the Chinese medicine composition are: 17 parts of Radix Paeoniae Alba, 15 parts of Epimedium, 7 parts of Ligustrum lucidum, 11 parts of Cuscuta chinensis, 16 parts of Caulis japonica, 8 parts of red ginseng , 8 parts of safflower, 16 parts of Eclipta, 14 parts of Rhodiola rosea, 11 parts of white leaves, 3 parts of Cistanche, 5 parts of medlar, 13 parts of Caulis Spatholobus, 14 parts of Cephalosporum, 5 parts of Mulberry, 12 parts of Shouwu, 3 parts of Snow Lotus, 1 part of Eucommia, 10 parts of Agrimony, 9 parts of Panax notoginseng, 13 parts of Polygonum cuspidatum, 7 parts of Gentiana, 11 parts of Ziheche, 3 parts of Sanleng, 1 part of blood, and 10 parts of Pueraria 4 parts of Motherwort, 11 parts of Morinda officinalis, 4 parts of Gastrodia elata, and 15 parts of black sesame.

Further, the composition and parts by weight of the raw materials for making the Chinese medicine composition are: 15 parts of Radix Paeoniae Alba, 12 parts of Epimedium, 5 parts of Ligustrum lucidum, 9 parts of Cuscuta chinensis, 15 parts of Caulis japonica, and 9 parts of red ginseng , 7 parts of safflower, 19 parts of Eclipta, 13 parts of rhodiola, 10 parts of white leaves, 4 parts of cistanche, 4 parts of medlar, 11 parts of Milletah, 11 parts of Rhizoma cerana, 5 parts of mulberry, 10 parts of Shouwu, 5 parts of Snow Lotus, 3 parts of Eucommia, 8 parts of Agrimony, 8 parts of Panax notoginseng, 14 parts of Polygonum cuspidatum, 9 parts of Gentiana chinensis, 12 parts of Ziheche, 5 parts of Sanleng, 3 parts of blood jellyfish, and 8 parts of kudzu root 6 parts of Motherwort, 9 parts of Morinda officinalis, 5 parts of Gastrodia elata, and 14 parts of black sesame.

Further, the composition and parts by weight of the raw materials for making the Chinese medicine composition are: 19 parts of Radix Paeoniae Alba, 14 parts of Epimedium, 6 parts of Ligustrum lucidum, 7 parts of Cuscuta chinensis, 14 parts of Caulis japonica, and 9 parts of red ginseng , 6 parts of safflower, 17 parts of Eclipta, 13 parts of Rhodiola rosea, 10 parts of white leaves, 4 parts of Cistanche, 4 parts of medlar, 11 parts of Caulis Spatholobus, 11 parts of Rhododendron, 5 parts of Mulberry, 10 parts of Shouwu, 5 parts of Snow Lotus, 3 parts of Eucommia, 8 parts of Agrimony, 8 parts of Panax notoginseng, 14 parts of Polygonum cuspidatum, 4 parts of Gentiana chinensis, 9 parts of Ziheche, 5 parts of Sanleng, 3 parts of blood jellyfish, and 8 parts of Pueraria lobata 3 parts of Motherwort, 8 parts of Morinda officinalis, 5 parts of Gastrodia elata, and 16 parts of black sesame.

Further, the traditional Chinese medicine composition is prepared according to the following method:

(1) Get each medical material of weight component in described Chinese medicine composition, pulverize into coarse powder, add the ethanol solution that volume concentration is 70%-95% according to 4-10 times of the total weight of coarse powder, reflux extraction three times, reflux The time is 3-5h, filter, recover ethanol from the filtrate, cool and filter, wash with water, and dry to obtain a dry extract;

(2) Grinding the dry extract prepared in step (1), adding an appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and sizing to obtain granules; or step (1) ) dried extract obtained, pulverized, and made into a powder; or the dried extract obtained in step (1) was pulverized, mixed with an appropriate amount of micropowdered silica gel and α-galactose, and granulated with ethanol as a wetting agent, Drying, granulation, packing into capsules to obtain capsules; or crushing the dry extract obtained in step (1), adding appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and granulation, Tablets are produced; or an appropriate amount of sucrose and essence are added to the centrifuged concentrate obtained in the above step (1), mixed, sterilized, and filled to obtain a liquid medicine.

The invention also relates to the application of a traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis in medicine for preventing and treating postmenopausal osteoporosis.

The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis provided by the present invention uses common Chinese herbal medicines as raw materials to give full play to the medicinal properties of each component:

Radix Paeoniae Alba, enter liver, spleen meridian, have the effect of nourishing blood and softening liver, relieving pain in the middle, astringing yin and sweating. Indications for chest and abdomen hypochondriac pain, diarrhea and abdominal pain, spontaneous sweating, night sweats, fever due to yin deficiency, irregular menstruation, uterine bleeding, leukorrhea embolism. Peppermint is one of the commonly used traditional Chinese medicines in China. It is a pungent and cool antipyretic medicine for sweating and treating influenza, headache, red eyes, body heat, sore throat and gums. External application can cure neuralgia, itchy skin, rash and eczema, etc. The mint picked in the Guangpeng Greenhouse is another fresh vegetable on the table during the Spring Festival. Refreshing and delicious. Usually use mint instead of tea to clear the heart and improve eyesight. Modern medicine has proved that peppermint has strong antiviral and antibacterial activity, and has certain antiallergic activity.

Epimedium, pungent, sweet, and warm, belongs to the liver and kidney meridians. "Compendium of Materia Medica" contains: "The nature is warm and not cold, and it can benefit essence and energy. It is also the medicine for the three energizers of the hands and feet." It is commonly used for various syndromes of kidney yang deficiency medicine. "Compendium of Materia Medica" contains: "Replenishing the gate of life, benefiting essence, strengthening muscles and bones, and facilitating urination."

Ligustrum lucidum is the dry ripe fruit of Oleaceae plant Ligustrum lucidum Ait. Harvest when the fruit is ripe in winter, remove branches and leaves, steam or put in boiling water for a while, and then dry; or directly dry. Nature and flavor are sweet, bitter, cool. Return liver, kidney channel. Can nourish the liver and kidney, improve eyesight and black hair. For liver and kidney yin deficiency, dizziness and tinnitus, soreness and weakness of the waist and knees, dry beard and hair, dark eyes, internal heat and quenching thirst, bone steaming and hot flashes.

Cuscutae: sweet, pungent, flat in nature, enters the liver, kidney, and spleen meridian, has the functions of nourishing the kidney and nourishing essence, nourishing the liver and improving eyesight, mainly used for impotence due to deficiency of kidney yang, seminal emission, premature ejaculation, frequent urination, dizziness and tinnitus; kidney deficiency, low back pain, Fetal qi is not solid when taken by a woman; liver and kidney deficiency, dim eyesight and blurred vision due to insufficient liver blood; loose stools and abdominal pain due to deficiency of both spleen and kidney, and inability to dissolve the grain.

Teng Yejiao: sweet and slightly bitter, flat. Go into the heart, Liver Channel. It has the effects of nourishing the heart, calming the nerves, dredging collaterals, and expelling wind. Control insomnia, overstrain, hyperhidrosis, blood deficiency body pain, carbuncle, scrofula, wind sore and scabies.

Polygonum cuspidatum: slightly bitter, slightly cold. Return liver, gallbladder, lung meridian. Function cures mainly dispelling wind and dampness, dispelling blood stasis and relieving pain, relieving cough and reducing phlegm. Used for arthralgia, damp-heat jaundice, amenorrhea, lump in the abdomen, water and fire burns, injuries from falls, carbuncles and sores, cough with excessive phlegm.

Red Ginseng: sweet, slightly bitter, warm. Return spleen, lung, heart channel. Functions and indications: tonify vital energy, restore pulse and solidify, replenish qi and absorb blood. It is used for the weakness of the body and the desire to dislodge, cold extremities and weak pulse, qi not absorbing blood, metrorrhagia and bleeding.

Eclipta japonica, sweet in taste, sour, cool in nature, returns to the liver and kidney channels, nourishes the liver and kidney; cools blood to stop bleeding. Insufficient liver and kidney; dizziness; premature graying of beard and hair; vomiting blood; hemoptysis; epistaxis; blood in stool; bloody dysentery; metrorrhagia; leakage; traumatic bleeding.

Rhodiola rosea: replenishing qi and activating blood circulation, dredging the veins and relieving asthma. It has the effects of improving sleep, promoting blood circulation, anti-brain hypoxia, anti-fatigue, promoting blood circulation and stopping bleeding, clearing lung and relieving cough, reducing stasis and swelling, antipyretic and fever, and nourishing vitality. The dried roots and rhizomes of Rhodiola grandiflora of the Crassulaceae plant were selected for use.

Knead white leaves, bitter, cool. Detoxification. For dysentery, acute gastroenteritis, stomatitis, urinary tract infection; for external use to treat burns, sores, swollen toxins, and itchy skin.

Herba Cistanche, sweet, salty, warm. Return kidney, large intestine channel. Tonifying kidney yang, benefiting essence and blood, moistening intestines and laxative. For impotence, infertility, soreness of the waist and knees, weakness of muscles and bones, dryness of the intestines and constipation. "The Classic": "Maintains five labors and seven injuries, nourishes the middle, removes cold and heat pain in the stem, nourishes the five internal organs, strengthens yin, benefits essence and qi, and relieves women's abdominal pain."

Eucommia ulmoides: nourishes liver and kidney, strengthens muscles and bones, and prevents miscarriage. It can treat back pain, remove garbage in the body, strengthen the metabolism of human cell substances, prevent musculoskeletal aging, balance human blood pressure, decompose cholesterol in the body, reduce body fat, restore blood vessel elasticity, diuresis and clear away heat, broad-spectrum antibacterial, excite the central nervous system, and improve blood circulation. Significant effects such as increasing the number of white blood cells and enhancing human immunity.

Lycium barbarum: It is the dry and mature fruit of Lycium barbarum L., a plant of the family Solanaceae. Nature and flavor are sweet, flat. Return liver, kidney, lung meridian. Efficacy: Nourish the liver, nourish the kidney.

Broken bone wind, bitter, temperature. Function cures mainly: expelling wind and removing dampness, promoting blood circulation and removing blood stasis. For rheumatic pain, lumbago, bruises.

Spatholobus Spatholobus suberectus Dunn is the dry cane of the leguminosae plant Spatholobus suberectus Dunn. Nature and flavor are bitter, sweet, warm. Return liver, kidney channel. Efficacy: nourishing blood, promoting blood circulation, dredging collaterals.

Mulberry: the leafy stems and branches of Loranthus parasiticus (L.) Merr. or mistletoe Viscumcoloratum (Komar.) Nakai. Nature and flavor are bitter, sweet, flat. Return liver, kidney channel. Efficacy: dispelling rheumatism, benefiting liver and kidney, strengthening muscles and bones. "Nihuazi Materia Medica": Helps muscles and bones, benefits blood vessels.

Shouwu: It is a processed product of the dried tuber root of Polygonum multiflorum Thunb. Nature and flavor are bitter, sweet, astringent, slightly warm. Return liver, heart, kidney channel. Efficacy: Nourishing liver and kidney, benefiting essence and blood, black beard and hair, strengthening bones and muscles.

Agrimonia pilose: the dry aerial part of Agrimoniapilose Ledeb. Nature and flavor are bitter, astringent, flat. GUIXIN, Liver Channel. Efficacy: astringent to stop bleeding.

Safflower is warm in nature and pungent in taste. Functions and indications apply to promoting blood circulation, dispelling blood stasis and relieving pain. For amenorrhea, dysmenorrhea, lochia, lumps in the abdomen, bruises. "Materia Medica Huiyan": Safflower, the medicine for breaking blood, promoting blood circulation, harmonizing blood, and regulating blood. The main fetal birth is caused by various diseases and blood, or blood troubles and blood dizziness, dizziness and silence; or lochia grabs the heart, umbilical abdominal colic; card, non-safflower cannot be cured. If postpartum haemorrhage, mouth silencing and finger pricking; or evil entering the blood chamber, delirium and madness; All such as amenorrhea and cold and heat, or expired abdominal pain with purple and black dripping, or injury from falls and blood stasis, or sores and sores with swelling and ulceration are all symptoms of disharmony between qi and blood, and non-safflower cannot Tune, safflower promotes blood circulation to stimulate menstruation, reduces swelling and relieves pain, has the effects of inhibiting thrombosis, anti-inflammation, and pain relief, has the effect of constricting blood vessels by eliminating adrenaline and norepinephrine, and has the effect of "tongli meridian".

Gentiana chinensis, hard work, flat. Go into liver, stomach, gallbladder meridian. Functions and indications: expelling wind and dampness, harmonizing blood and relaxing tendons, clearing away heat and diuresis. Control rheumatic arthralgia, muscle and bone spasms, jaundice, blood in the stool, bone steam hot flashes, infantile malnutrition, dysuria.

Ziheche: sweet, salty, warm, nourishing, soothing and nourishing blood, nourishing qi, tonifying essence, detoxifying, etc.

Sanleng: spicy; astringent; cool. Into the liver. Spleen meridian. Treatment of lumps in the abdomen, accumulation, hypochondrium distending pain, food accumulation distending pain, dysmenorrhea, amenorrhea, postpartum blood stasis abdominal pain, bruises. Mongolian medicine is used to treat cough due to lung heat, asthma with excessive phlegm, liver heat, pulse heat, tuberculosis heat and bone steaming, "Bao Ri" disease, and bone fractures.

Saussurea: Saussurea has physiologically active active ingredients. Among them, umbelliferone has obvious antibacterial, antihypertensive, sedative, and antispasmodic effects; it has wind-dispelling, anti-inflammatory, pain-relieving, expectorant, and anti-tumor effects, and can inhibit the growth of cancer cells. It is clinically used to treat cancer, especially with Breast cancer has a certain effect, and it also has a certain effect on skin cancer, leukemia and He Jin's disease. Specific effect on acute attack of gout.

Dried blood: oral administration for promoting blood circulation and dissipating blood stasis, analgesic therapy, external application for hemostasis and granulation promoting, astringing sores. Indications: ① Congestion, amenorrhea, dysmenorrhea, and postpartum stasis. ② lump in the abdomen, tingling pain in the chest and abdomen. ③ bruises, congestion, swelling and pain. ④ traumatic bleeding, ulcers are not restrained. Use Liliaceae Dracaena or Cambodian Dracaena resin.

Motherwort: spicy and sweet in taste, slightly warm in air, nontoxic. Go into the heart, liver, urinary bladder channel. Promoting blood circulation, dispelling blood stasis, regulating menstruation, eliminating water. Control irregular menstruation, fetal leakage and dystocia, retained afterbirth, postpartum haemorrhage, abdominal pain due to blood stasis, metrorrhagia, hematuria, diarrhea, carbuncle sores.

Radix Notoginseng: Radix Notoginseng is sweet in nature, slightly bitter in taste, warm in nature, and returns to the liver and stomach meridians. Its roots and rhizomes are used as medicine. It is a precious Chinese herbal medicine. It can stop bleeding, remove blood stasis, reduce swelling and relieve pain when used raw. It has good hemostatic effect and significant hematopoietic function; it can strengthen and improve coronary microcirculation. Sanqi has a long history of being used as medicine. Therefore, there is a saying that "gold is not exchanged". Notoginseng "slightly sweet and bitter, similar to the taste of ginseng." "Anyone who is injured by a stick and bruised and dripping with blood should stop immediately after chewing, and the bruise will disappear. If you receive a stick, take a dose first. , two coins, the blood does not rush to the heart, it is especially suitable to be taken after the stick, and it is also good to take after giving birth. Generally speaking, this medicine has a warm temperature, sweet and slightly bitter taste, and it is divided into Yangming and Jueyin blood, so it can cure all blood diseases." . "Materia Medica Seeking Truth" records: "Sanqi, the world only knows its function to stop bleeding and relieve pain. They don't know that pain is caused by blood stasis, and blood stops due to application. The smell of Sanqi is bitter and warm, and it can differentiate blood stasis in the blood." Panax notoginseng can increase coronary blood flow, slow down heart rate, reduce myocardial oxygen consumption, increase myocardial oxygen tolerance, improve microcirculation, and relieve smooth muscle spasm.

Radix Puerariae, sweet in taste, pungent, cool in nature. Go into spleen, stomach warp. It has the effects of promoting yang and relieving muscles, penetrating rash and stopping diarrhea, eliminating restlessness and stopping temperature. It is used for typhoid fever, warm-heat headache and strong neck, dysphoria and thirst, diarrhea, dysentery, impervious rash, high blood pressure, angina pectoris, and deafness. It is clinically used to treat stiff neck pain in hypertension, angina pectoris in coronary heart disease, and also has hypoglycemic effect.

Morinda officinalis, sweet, pungent, slightly warm. Return kidney, Liver Channel. Function cures mainly: invigorating kidney yang, strengthening muscles and bones, expelling rheumatism. For impotence and nocturnal emission, cold uterine infertility, irregular menstruation, cold pain in the lower abdomen, rheumatism arthralgia, flaccidity of muscles and bones.

Gastrodia elata: sex, flat. taste, sweet. Mainly enters the Liver Channel. This product relieves wind and spasm, calms liver-yang, dispels wind and dredges collaterals. It is an important medicine for treating dizziness and headache; it is also a good product for numbness of limbs, paralysis of hands and feet, rheumatic arthralgia, and spasm of muscles and bones.

Black Sesame: Nourishing liver and kidney, benefiting essence and blood, moistening intestines and dryness. For dizziness, tinnitus and deafness, premature graying of beard and hair, hair loss after illness, intestinal dryness and constipation.

In the traditional Chinese medicine composition of the present invention, Rhodiola has the effects of invigorating qi and clearing the lungs, improving intelligence and nourishing the heart, reducing astringency and hemostasis, dissipating blood stasis and reducing swelling, Polygonum cuspidatum dispelling wind and dampness, dissipating blood stasis and relieving pain, relieving cough and reducing phlegm, Zihe Che'anxin nourishes blood, nourishes qi, nourishes essence, detoxifies, and is a king drug;

Red ginseng nourishes the vital energy, restores the veins and strengthens the veins, nourishes the blood and nourishes the blood, Eclipta tonifies the liver and kidney, cools the blood to stop bleeding, and treats liver and kidney deficiency, rubs the white leaves for bruises, rheumatism and muscle pain, white peony nourishes blood and softens Liver, relieves pain in the middle, restrains yin and absorbs sweat, Tengjiao Tengshen soothes the nerves, dredges collaterals, dispels wind, and is a ministerial drug in the prescription;

Accompanied by broken bone wind, wolfberry fruit, Caulis Spatholobus, etc. as adjuvant drugs, wherein broken bone wind is mainly used for expelling wind and dampness, promoting blood circulation and relieving pain, treating rheumatism, waist and leg joint pain, bruises, sores, and ulcers; wolfberry fruit nourishes the liver , nourishing the kidney; Caulis Spatholobus tonifies blood, activates blood circulation, dredges collaterals; Gentiana quinquefolium dispels wind-damp, clears damp-heat, relieves arthralgia and pain; Triangle treats lumps in the abdomen, accumulation, hypochondrium pain, dysmenorrhea, amenorrhea, postpartum blood stasis and abdominal pain , bruises; Saussurea expelling wind, anti-inflammation, pain relief, expectorant, notoginseng to stop bleeding, remove blood stasis, reduce swelling and relieve pain, blood exhaustion, promote blood circulation and remove blood stasis, relieve pain, kudzu root promote yang and relieve muscle, penetrate rash and stop diarrhea, eliminate restlessness and relieve pain Warm, Gastrodia elata calms wind and spasm, calms liver yang, dispels wind and dredges collaterals, epimedium, pungent, sweet, and warm, returns to liver and kidney meridians, and is a commonly used medicine for various syndromes of kidney yang deficiency, Cuscuta nourishes kidney and essence, nourishes liver and improves eyesight , Cistanche tonifies kidney yang, nourishes essence and blood, Eucommia, Sangjisheng, Zhishouwu nourishes liver and kidney, strengthens muscles and bones, prevents miscarriage, safflower promotes blood circulation, dissipates blood stasis and relieves pain, agrimony astringes to stop bleeding.

Motherwort promotes blood circulation, removes blood stasis, regulates menstruation, eliminates water, black sesame nourishes liver and kidney, nourishes essence and blood, moisturizes intestines, Morinda officinalis nourishes kidney yang, strengthens muscles and bones, dispels rheumatism, and Ligustrum lucidum nourishes liver and kidney.

The selected medicinal materials of the Chinese medicine composition of the present invention are suitable for compatibility, which conforms to the theory of traditional Chinese medicine and modern medicine, and its compatibility conforms to the principle of "junchenzuoshi" of traditional Chinese medicine, and has a unique curative effect on postmenopausal osteoporosis. The medicine is scientifically compatible, and the curative effect is rapid and effective Fast, short course of treatment, high cure rate, low cost advantages.

detailed description

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments. Apparently, the described embodiments are part, but not all, of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention. Unless otherwise specified, the percentage of ethanol in the present invention is volume percentage, and v/v represents the volume ratio of the solution.

Example 1:

A kind of Chinese medicine composition of preventing and treating postmenopausal osteoporosis of the present invention, get following Chinese medicine crude drug: Radix Paeoniae Alba 12 grams, Epimedium 16 grams, Ligustrum lucidum 3 grams, Cuscuta 12 grams, Caulis Noctua 12 grams, 10 grams of red ginseng, 9 grams of safflower, 15 grams of Eclipta, 15 grams of rhodiola, 8 grams of rubbed white leaves, 5 grams of Cistanche, 3 grams of medlar, 14 grams of Caulis Spatholobus, 9 grams of Rhododendron, mulberry Parasitic 6 grams, Zhishouwu 8 grams, Saussurea 5 grams, Eucommia 1 gram, Agrimony 10 grams, Panax notoginseng 5 grams, Polygonum cuspidatum 16 grams, Gentiana chinensis 10 grams, Ziheche 8 grams, Sanleng 5 grams, dried blood 1 10 grams of kudzu root, 6 grams of motherwort, 8 grams of Morinda officinalis, 3 grams of Gastrodia elata, and 13 grams of black sesame.

Example 2:

A kind of traditional Chinese medicine composition of prevention and treatment of postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine crude drug: Radix Paeoniae Alba 20 grams, Epimedium 10 grams, Ligustrum lucidum 8 grams, Cuscuta 5 grams, Caulis Noctua 17 grams, 12 grams of red ginseng, 4 grams of safflower, 20 grams of Eclipta, 10 grams of rhodiola, 12 grams of kneading white leaves, 2 grams of Cistanche, 7 grams of medlar, 11 grams of Caulis Spatholobus, 15 grams of Rhododendron, mulberry 3 grams of Parasitic, 13 grams of Zhishouwu, 3 grams of Snow Lotus, 3 grams of Eucommia, 5 grams of Agrimony, 10 grams of Panax notoginseng, 13 grams of Polygonum cuspidatum, 3 grams of Gentiana chinensis, 13 grams of Ziheche, 3 grams of trigonum, 3 grams of dried blood 5 grams of kudzu root, 4 grams of motherwort, 10 grams of Morinda officinalis, 4 grams of Gastrodia elata, and 16 grams of black sesame.

Example 3:

A kind of traditional Chinese medicine composition of preventing and treating postmenopausal osteoporosis of the present invention, take following traditional Chinese medicine crude drug: Radix Paeoniae Alba 13 grams, Epimedium 11 grams, Ligustrum lucidum 4 grams, Cuscuta 6 grams, Caulis 13 grams, 7 grams of red ginseng, 5 grams of safflower, 18 grams of Eclipta, 11 grams of rhodiola, 9 grams of rubbed white leaves, 4 grams of Cistanche, 6 grams of medlar, 12 grams of Caulis Spatholobus, 13 grams of Rhododendron, mulberry 4 grams of Parasitic, 9 grams of Zhishouwu, 4 grams of Snow Lotus, 2 grams of Eucommia, 6 grams of Agrimony, 6 grams of Panax notoginseng, 14 grams of Polygonum cuspidatum, 5 grams of Gentiana chinensis, 10 grams of Ziheche, 4 grams of Sanleng, 2 6 grams of kudzu root, 5 grams of motherwort, 12 grams of Morinda officinalis, 3 grams of Gastrodia elata, and 14 grams of black sesame.

Example 4:

A kind of traditional Chinese medicine composition of prevention and treatment of postmenopausal osteoporosis of the present invention, take following traditional Chinese medicine crude drug: Radix Paeoniae Alba 17 grams, Epimedium 15 grams, Ligustrum lucidum 7 grams, Cuscuta 11 grams, Caulis Noctua 16 grams, 8 grams of red ginseng, 8 grams of safflower, 16 grams of Eclipta, 14 grams of rhodiola, 11 grams of rubbed white leaves, 3 grams of Cistanche, 5 grams of medlar, 13 grams of Caulis Spatholobus, 14 grams of Rhododendron, mulberry 5 grams of Parasitic, 12 grams of Shouwu, 3 grams of Snow Lotus, 1 gram of Eucommia, 10 grams of Agrimony, 9 grams of Panax notoginseng, 13 grams of Polygonum cuspidatum, 7 grams of Gentiana chinensis, 11 grams of Ziheche, 3 grams of trigonum, 1 10 grams of kudzu root, 4 grams of motherwort, 11 grams of Morinda officinalis, 4 grams of Gastrodia elata, and 15 grams of black sesame.

Example 5:

A kind of Chinese medicine composition of preventing and treating postmenopausal osteoporosis of the present invention, get following Chinese medicine crude drug: Radix Paeoniae Alba 15 grams, Epimedium 12 grams, Ligustrum lucidum 5 grams, Cuscuta 9 grams, Caulis Noctua 15 grams, 9 grams of red ginseng, 7 grams of safflower, 19 grams of Eclipta, 13 grams of rhodiola, 10 grams of white leaves, 4 grams of Cistanche, 4 grams of medlar, 11 grams of Caulis Spatholobus, 11 grams of Rhododendron, mulberry 5 grams of Parasitic, 10 grams of Zhishouwu, 5 grams of Snow Lotus, 3 grams of Eucommia, 8 grams of Agrimony, 8 grams of Panax notoginseng, 14 grams of Polygonum cuspidatum, 9 grams of Gentiana chinensis, 12 grams of Ziheche, 5 grams of trigonum, and 3 grams of blood 8 grams of kudzu root, 6 grams of Motherwort, 9 grams of Morinda officinalis, 5 grams of Gastrodia elata, and 14 grams of black sesame.

Embodiment 6:

A kind of traditional Chinese medicine composition of prevention and treatment of postmenopausal osteoporosis of the present invention, take following traditional Chinese medicine crude drug: Radix Paeoniae Alba 19 grams, Epimedium 14 grams, Ligustrum lucidum 6 grams, Cuscuta 7 grams, Caulis Noctua 14 grams, 9 grams of red ginseng, 6 grams of safflower, 17 grams of Eclipta, 13 grams of rhodiola, 10 grams of rubbing white leaves, 4 grams of Cistanche, 4 grams of medlar, 11 grams of Caulis Spatholobus, 11 grams of Rhododendron, mulberry 5 grams of Parasitic, 10 grams of Zhishouwu, 5 grams of Snow Lotus, 3 grams of Eucommia, 8 grams of Agrimony, 8 grams of Panax notoginseng, 14 grams of Polygonum cuspidatum, 4 grams of Gentiana chinensis, 9 grams of Ziheche, 5 grams of trigonum, 3 grams of blood 8 grams of kudzu root, 3 grams of Motherwort, 8 grams of Morinda officinalis, 5 grams of Gastrodia elata, and 16 grams of black sesame.

Wherein, the preparation method of the described Chinese medicine composition of embodiment 1-6 is:

(1) Get each medical material of weight component in the Chinese medicine composition described in any one of embodiments 1-6, be ground into coarse powder, add the ethanol that volume concentration is 70%-95% according to 4-10 times of coarse powder gross weight Solution, reflux extraction three times, the reflux time is 3-5h, filter, recover ethanol from the filtrate, cool and filter, wash with water, dry to obtain dry extract;

(2) Grinding the dry extract prepared in step (1), adding an appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and sizing to obtain granules; or step (1) ) dried extract obtained, pulverized, and made into a powder; or the dried extract obtained in step (1) was pulverized, mixed with an appropriate amount of micropowdered silica gel and α-galactose, and granulated with ethanol as a wetting agent, Drying, granulation, packing into capsules to obtain capsules; or crushing the dry extract obtained in step (1), adding appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and granulation, Tablets are produced; or an appropriate amount of sucrose and essence are added to the centrifuged concentrate obtained in the above step (1), mixed, sterilized, and filled to obtain a liquid medicine.

Acute toxicity test:

Get 60 mice with a body weight of 22-25 grams. The capsule solution was administrated to the mice, and the median lethal dose (LD50) of the administration was tested and determined, but the LD50 was not detected, so the maximum tolerated dose test was carried out. Result: with the maximum dosage of 120g/kg orally, which is equivalent to 280 times of adult clinical proposed daily dose, no mouse died within seven days, and no toxic reaction was found in the organs of the sacrificed mice. There were no differences in the control mice.

Six-month long-term toxicity test: Take 60 rats, weighing 180-220g, set the experimental drug to three doses of high, medium and low, respectively capsules 40g/kg, 20g/kg, 10g/kg, according to human Calculated with (75kg as the standard) dose of 1.1g/kg/day, it is 40 times, 20 times and 10 times of the effective dose for humans; another control group is set up, and it is administered continuously for 90 days, 180 days and some animals stop the drug After 10 days, the effects on various physiological and biochemical indexes of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, blood biochemistry, urine biochemistry and bone marrow slices, and there was no significant difference between each group and the control group.

Clinical Trials:

In order to verify the effect of the traditional Chinese medicine composition of the present invention, from January 2013 to November 2014, 200 patients with postmenopausal osteoporosis were randomly selected in the outpatient department, aged 60 to 82 years old, with an average of 66±2.7 years old, and divided into the experimental group And the control group, 100 cases in each group, the two groups were statistically analyzed in terms of age, menopausal years, height, weight and bone density, and the difference was not statistically significant (P>0.05), which was comparable.

Diagnostic criteria:

The diagnostic criteria for primary osteoporosis were formulated according to the "Guiding Principles for Clinical Research of New Chinese Medicines":

(1) There is general weakness and bone pain, mostly manifested by low back pain, which gradually worsens, may have kyphosis, and may cause fractures due to minor trauma;

(2) X-ray findings: the bones are generally sparse, especially in the spine, pelvis, and upper end of the femur. The changes in the spine are the most special. The vertebral body may appear fishtail-like double concave shape, the intervertebral space is widened, there are Schmorl nodules, the thoracic vertebrae are wedge-shaped, and the affected vertebral bodies are multiple and scattered;

(3) The peak bone density measured by dual-energy X-ray examination is greater than or equal to 2.5 standard deviations lower than that of healthy adults of the same sex and race.

TCM syndrome differentiation criteria:

(1) Main symptoms: ① Lumbar spine pain or bone pain all over the body; ② Soreness and weakness of the waist and knees.

(2) Secondary symptoms: ① Vertebral percussion pain or tenderness; ② Inability to hold weight; ③ Lower limbs are thin or numb; ④ Vertigo and tinnitus; ⑤ Reddish or pale tongue;

It is sufficient to have 2 of the main symptoms and one of the items ①～④ of the secondary symptoms.

Exclusion criteria:

Exclude patients with serious primary diseases of important organs such as heart, brain, kidney, and diseases affecting bone metabolism, those who have taken drugs that affect bone metabolism in the past six months, and those with fresh fractures.

treatment method:

The course of treatment for both the experimental group and the control group was 12 weeks.

Treatment group: take the tablet of the traditional Chinese medicine composition of the embodiment 3 of the present invention, 3 times a day, each time in the morning, noon and evening, 3 tablets each time, every 7 days is a course of treatment.

Control group: use salmon calcitonin injection (Beijing Shuanglu Pharmaceutical Co., Ltd., H20020694), after the skin test is negative, the first week: once a day, 50U each time, intramuscular injection; the second Week: once every other day, 50U each time, intramuscular injection; 3rd to 12th weeks: once a week, 50U each time, intramuscular injection.

Efficacy Judgment Criteria:

According to the standard of "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine":

Recovery: no pain, sore waist and knees, flaccidity and weakness of lower limbs, dizziness and tinnitus were significantly improved, and bone density increased by more than 2%.

Effective: the pain is significantly relieved, the waist and knees are sore and limp, the lower limbs are flaccid and weak, the symptoms of vertigo and tinnitus are partially improved, and the bone density value is increased by (0-2)%.

Invalid: No improvement in all aspects. Bone mineral density (BMD) of the lumbar spine and left femoral neck was measured by dual-energy X-ray absorptiometry in all patients before and after treatment.

Bone density curative effect standard calculation method: (T score percentage after treatment - T score percentage before treatment) × 100%.

result:

Comparison of curative effects between the two groups: the total effective rate of the treatment group was 96%, and the total effective rate of the control group was 65%; the difference between the two groups was significant and statistically significant (P<0.05).

The clinical observation results are shown in Table 1:

group cases cure markedly effective efficient invalid total effective rate control group 100 25 29 11 35 65% therapy group 100 76 13 7 4 96%

The above results showed that the cure rate and total effective rate of the treatment group were significantly higher than those of the control group.

Table 2: Comparison of BMD detection results before and after treatment in the two groups (g·cm-2, x±s)

Clinical curative effect observation results show that the Chinese medicine composition of the present invention has significant curative effect for preventing and treating postmenopausal osteoporosis; Safety observation finds that no clinical adverse reactions are observed, indicating that the Chinese medicine composition of the present invention is safe in clinical application and has no side effects .

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be Modifications are made to the technical solutions described in the foregoing embodiments, or equivalent replacements are made to some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. a Chinese medicine composition for preventing and treating postmenopausal osteoporosis, is characterized in that: the raw material drug of described Chinese medicine composition is made of Radix Paeoniae Alba, Epimedium, Ligustrum lucidum, Cuscuta Semen, Nightingale, Polygonum cuspidatum, Red Ginseng , Eclipta, Rhodiola, rubbing white leaves, Cistanche, Eucommia, medlar, Cracker, Millae, Sangji, Zhishouwu, Agrimony, safflower, Gentiana, Ziheche, Sanleng, Composition of snow lotus, dried blood, motherwort, notoginseng, kudzu root, Morinda officinalis, Gastrodia elata, and black sesame. 2. The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 1, characterized in that: the composition and parts by weight of raw materials for making said Chinese medicine composition are: Radix Paeoniae Alba 12-20 parts, Epimedium 10-16 parts of hydrangea, 3-8 parts of Ligustrum lucidum, 5-12 parts of Cuscuta, 12-17 parts of Noctilucia, 7-12 parts of red ginseng, 4-9 parts of safflower, 15-20 parts of Eclipta chinensis, 10-15 parts of rhodiola, 8-12 parts of kneading white leaves, 2-5 parts of cistanche, 3-7 parts of medlar, 11-14 parts of Caulis Spatholobus, 9-15 parts of broken bones, 3-6 parts of mulberry 8-13 parts of Shouwu, 3-5 parts of Snow Lotus, 1-3 parts of Eucommia, 5-10 parts of Agrimony, 5-10 parts of Panax notoginseng, 13-16 parts of Polygonum cuspidatum, 3-10 parts of Gentiana, Zihe 8-13 parts of car, 3-5 parts of Sanlong, 1-3 parts of dried blood, 5-10 parts of kudzu root, 3-6 parts of Motherwort, 8-13 parts of Morinda officinalis, 3-5 parts of Gastrodia elata, 13- 16 servings. 3. The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 2, characterized in that: the composition and parts by weight of raw materials for making said Chinese medicine composition are: 12 parts of Radix Paeoniae Alba, 16 parts of Epimedium 3 parts of Ligustrum lucidum, 12 parts of dodder, 12 parts of vine, 10 parts of red ginseng, 9 parts of safflower, 15 parts of Eclipta, 15 parts of rhodiola, 8 parts of white leaves, 5 parts of Cistanche, 3 parts of Lycium barbarum, 14 parts of Caulis Spatholobus, 9 parts of Crackers, 6 parts of Sangjisheng, 8 parts of Zhiwu, 5 parts of Snow Lotus, 1 part of Eucommia, 10 parts of Agrimony, 5 parts of Panax notoginseng, 16 parts of Polygonum cuspidatum, 10 parts of Gentiana chinensis, 8 parts of Ziheche, 5 parts of Sanleng, 1 part of dried blood, 10 parts of Pueraria lobata, 6 parts of motherwort, 8 parts of Morinda officinalis, 3 parts of Gastrodia elata, and 13 parts of black sesame. 4. The Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 2, characterized in that: the composition and parts by weight of raw materials for making said Chinese medicine composition are: 20 parts of Radix Paeoniae Alba, 10 parts of Epimedium 8 parts of Ligustrum lucidum, 5 parts of Cuscuta, 17 parts of night vine, 12 parts of red ginseng, 4 parts of safflower, 20 parts of Eclipta, 10 parts of Rhodiola rosea, 12 parts of white leaves, 2 parts of Cistanche, 7 parts of Lycium barbarum, 11 parts of Caulis Spatholobus, 15 parts of Bone Rhizoma, 3 parts of Sang Ji Sheng, 13 parts of Radix Polygoni Multiflori, 3 parts of Snow Lotus, 3 parts of Eucommia, 5 parts of Agrimony, 10 parts of Panax notoginseng, 13 parts of Polygonum cuspidatum, 3 parts of Gentiana, 13 parts of Ziheche, 3 parts of Sanleng, 3 parts of blood, 5 parts of Pueraria root, 4 parts of motherwort, 10 parts of Morinda officinalis, 4 parts of Gastrodia elata, and 16 parts of black sesame. 5. The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 2, characterized in that: the composition and parts by weight of raw materials for making said Chinese medicine composition are: 13 parts of Radix Paeoniae Alba, 11 parts of Epimedium 4 parts of Ligustrum lucidum, 6 parts of Cuscuta, 13 parts of night vine, 7 parts of red ginseng, 5 parts of safflower, 18 parts of Eclipta, 11 parts of rhodiola, 9 parts of white leaves, 4 parts of Cistanche, 6 parts of Lycium barbarum, 12 parts of Caulis Spatholobus, 13 parts of Bone Rhizoma, 4 parts of Sang Ji Sheng, 9 parts of Radix Polygoni Multiflori, 4 parts of Snow Lotus, 2 parts of Eucommia, 6 parts of Agrimony, 6 parts of Panax notoginseng, 14 parts of Polygonum cuspidatum, 5 parts of Gentiana, 10 parts of Ziheche, 4 parts of Sanleng, 2 parts of blood, 6 parts of Pueraria root, 5 parts of motherwort, 12 parts of Morinda officinalis, 3 parts of Gastrodia elata, and 14 parts of black sesame. 6. The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 2, characterized in that: the composition and parts by weight of raw materials for making said Chinese medicine composition are: 17 parts of Radix Paeoniae Alba, 15 parts of Epimedium 7 parts of privet privet, 11 parts of dodder, 16 parts of vine, 8 parts of red ginseng, 8 parts of safflower, 16 parts of Eclipta, 14 parts of rhodiola, 11 parts of white leaves, 3 parts of Cistanche, 5 parts of Lycium barbarum, 13 parts of Caulis Spatholobus, 14 parts of Bone Rhizoma, 5 parts of Sang Ji Sheng, 12 parts of Radix Polygoni Multiflori, 3 parts of Snow Lotus, 1 part of Eucommia, 10 parts of Agrimony, 9 parts of Panax notoginseng, 13 parts of Polygonum cuspidatum, 7 parts of Gentiana, 11 parts of Ziheche, 3 parts of Sanleng, 1 part of blood, 10 parts of Pueraria root, 4 parts of motherwort, 11 parts of Morinda officinalis, 4 parts of Gastrodia elata, and 15 parts of black sesame. 7. The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 2, characterized in that: the composition and parts by weight of raw materials for making said Chinese medicine composition are: 15 parts of Radix Paeoniae Alba, 12 parts of Epimedium 5 parts of Ligustrum lucidum, 9 parts of Cuscuta, 15 parts of night vine, 9 parts of red ginseng, 7 parts of safflower, 19 parts of Eclipta, 13 parts of rhodiola, 10 parts of white leaves, 4 parts of Cistanche, 4 parts of Lycium barbarum, 11 parts of Caulis Spatholobus, 11 parts of Bone Rhizoma, 5 parts of Sang Ji Sheng, 10 parts of Radix Polygoni Multiflori, 5 parts of Snow Lotus, 3 parts of Eucommia, 8 parts of Agrimony, 8 parts of Panax notoginseng, 14 parts of Polygonum cuspidatum, 9 parts of Gentiana, 12 parts of Ziheche, 5 parts of Sanleng, 3 parts of blood, 8 parts of Pueraria lobata, 6 parts of motherwort, 9 parts of Morinda officinalis, 5 parts of Gastrodia elata, and 14 parts of black sesame. 8. The traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to claim 2, characterized in that: the raw material composition and parts by weight for making said Chinese medicine composition are: 19 parts of Radix Paeoniae Alba, 14 parts of Epimedium 6 parts of Ligustrum lucidum, 7 parts of Cuscuta, 14 parts of night vine, 9 parts of red ginseng, 6 parts of safflower, 17 parts of Eclipta, 13 parts of rhodiola, 10 parts of white leaves, 4 parts of Cistanche, 4 parts of Lycium barbarum, 11 parts of Caulis Spatholobus, 11 parts of Bone Rhizoma, 5 parts of Sang Ji Sheng, 10 parts of Radix Polygoni Multiflori, 5 parts of Snow Lotus, 3 parts of Eucommia, 8 parts of Agrimony, 8 parts of Panax notoginseng, 14 parts of Polygonum cuspidatum, 4 parts of Gentiana, 9 parts of Ziheche, 5 parts of Sanleng, 3 parts of blood, 8 parts of Pueraria lobata, 3 parts of Motherwort, 8 parts of Morinda officinalis, 5 parts of Gastrodia elata, and 16 parts of black sesame. 9. The Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to any one of claims 2-8, characterized in that, said Chinese medicine composition is prepared according to the following method: (1) Get each medical material of weight component in the arbitrary described Chinese medicine composition of claim 2-8, be ground into coarse powder, add the ethanol that volume concentration is 70%-95% according to 4-10 times of coarse powder gross weight Solution, reflux extraction three times, the reflux time is 3-5h, filter, recover ethanol from the filtrate, cool and filter, wash with water, dry to obtain dry extract; (2) Grinding the dry extract prepared in step (1), adding an appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and sizing to obtain granules; or step (1) ) dried extract obtained, pulverized, and made into a powder; or the dried extract obtained in step (1) was pulverized, mixed with an appropriate amount of micropowdered silica gel and α-galactose, and granulated with ethanol as a wetting agent, Drying, granulation, packing into capsules to obtain capsules; or crushing the dry extract obtained in step (1), adding appropriate amount of sucrose and dextrin to mix, using ethanol as a wetting agent, granulating, drying, and granulation, Tablets are produced; or an appropriate amount of sucrose and essence are added to the centrifuged concentrate obtained in the above step (1), mixed, sterilized, and filled to obtain a liquid medicine. 10. The application of the traditional Chinese medicine composition for preventing and treating postmenopausal osteoporosis according to any one of claims 1-9 in the medicine for preventing and treating postmenopausal osteoporosis.