CN104351208B - A kind of containing ZEN 90160 and the bactericidal composition of cycloheximide triazole and application - Google Patents
A kind of containing ZEN 90160 and the bactericidal composition of cycloheximide triazole and application Download PDFInfo
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- CN104351208B CN104351208B CN201410629418.9A CN201410629418A CN104351208B CN 104351208 B CN104351208 B CN 104351208B CN 201410629418 A CN201410629418 A CN 201410629418A CN 104351208 B CN104351208 B CN 104351208B
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- Prior art keywords
- zen
- bactericidal composition
- cycloheximide triazole
- cycloheximide
- triazole
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- 239000003381 stabilizer Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing ZEN 90160 and the bactericidal composition of cycloheximide triazole and application.This bactericidal composition is with ZEN 90160 and cycloheximide triazole as principle active component, and wherein ZEN 90160 is 1～90:1～90 with the weight ratio of cycloheximide triazole.This bactericidal composition can be applicable to prevent and treat Cereal, fruit tree, vegetable disease, has higher synergistic function, overcomes and delayed the Drug resistance of pathogenic bacteria, and sterilization speed is fast, lasting period length, reduce application cost, and prevention effect is substantially better than its single dose and uses.The present invention may be used for preventing and treating the fungal disease on crops, it is particularly possible to is used for preventing and treating the fungal diseases such as powdery mildew, rust, Ying's rot, net blotch, downy mildew, gray mold, anthrachose of grape, anthrax, epidemic disease and damping-off, and effect is better than single dose and uses.
Description
Technical field
The present invention relates to a kind of bactericidal composition and application thereof, especially one become for chief active with ZEN 90160 with cycloheximide triazole
The bactericidal composition divided and application thereof.
Background technology
ZEN 90160 (Picoxystrobin), chemical name: (E)-3-methoxyl group-2-{2-[6-(trifluoromethyl)-2-pyridine oxygen methyl]
Phenyl } acrylic acid methyl ester., molecular formula: C18H16F3NO4.Structural formula is as follows:
The mechanism of action and feature: mitochondrial respiratory inhibitor, i.e. by the suppression line grain of electron transfer between cytochrome b and C1
The breathing of body.Prevent and treat and 14-demethylation enzyme inhibitor, benzamides, tri carboxylic acid amide class and benzimidazole are produced resistance
Bacterial strain effective.ZEN 90160 is once absorbed by blade, will move in xylem, flows in transportation system with current；
It also flows and along with flowing in xylem again after being absorbed into blade from gas phase in the gas phase of blade surface.Due to pyridine oxygen
The systemic activity of bacterium ester and fumigation activity, thus after dispenser, effective ingredient can effectively reallocate and fully transmit, therefore pyridine oxygen bacterium
Ester has extraordinary therapeutic activity.Break and recommend under dosage to crop safety, without poisoning.ZEN 90160 controlling object wide spectrum, interior suction
Property strong, resistance of rainwater washing against.It is mainly used in preventing and treating Cereal, fruit tree and foliage disease such as the leaf blight, leaf rust of vegetable, clever withered
Disease, brown spot, powdery mildew, scab, anthrax, brown spot etc..
Cycloheximide triazole (Famoxadone), chemical name: 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1,3-oxazoline-2,4-
Diketone, molecular formula: C22H18N2O4, chemical structural formula is as follows:
Cycloheximide triazole belongs to azoles fungicide, have protection, treat, root out, permeate, systemic activity.Mechanism of action is energy
Inhibitor, i.e. Mitochondrial electron transmission suppression system.For Semen Tritici aestivi, Fructus Hordei Vulgaris, Semen Pisi sativi, Radix Betae, Brassica campestris L, Fructus Lycopersici esculenti, Fructus Capsici, melon
Class, Rhizoma Solani tuber osi.Prevent and treat the important disease in Ascomycetes, Basidiomycetes, Oomycete, such as powdery mildew, downy mildew, filigree
Disease, rust, glume blight, late blight etc., and can compound with other protective fungicides.Thus cycloheximide triazole is widely used
A kind of antibacterial.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, along with economy such as the change of pattern of farming, melon fruits and vegetables
Crops planting area progressively expands, and disease occurrence degree, generation quantity all increase, and in preventing and treating, difficulty strengthens；The opposing party
Face, the resistance of pathogen rises under lasting medicament selection pressure year by year, and the prevention effect of single dose is had a greatly reduced quality, plant disease
Preventing and treating is faced with significant challenge.
Summary of the invention
It is an object of the invention to provide a kind of applied widely, low cost for above-mentioned technical problem, effective containing ZEN 90160
Plant bactericidal composition with cycloheximide triazole.
A further object of the invention is the application as preparation preventing and treating fungal diseases of plants medicine of this bactericidal composition, especially should
Bactericidal composition as preparation prevent and treat powdery mildew, rust, Ying's rot, net blotch, downy mildew, gray mold, anthrachose of grape,
Anthrax, epidemic disease and the application of damping-off medicine.
It is an object of the invention to be realized by following measures:
A kind of containing ZEN 90160 with the bactericidal composition of cycloheximide triazole, the effective ingredient of this bactericidal composition is ZEN 90160 and azoles
Bacterium ketone, wherein, ZEN 90160 is 1～90:1～90 with the weight ratio of cycloheximide triazole；Preferably described ZEN 90160 and azoles bacterium
The weight ratio of ketone is 1～20:1～45；The most described ZEN 90160 is 1～10 with the weight ratio of cycloheximide triazole:
1～8.
Of the present invention containing ZEN 90160 with the bactericidal composition of cycloheximide triazole, both described ZEN 90160 and cycloheximide triazole account for
The weight percentage of bactericidal composition is 2～90%；Both preferably described ZEN 90160 and cycloheximide triazole account for bactericidal composition
Weight percentage is 10～80%；Both the most described ZEN 90160 and cycloheximide triazole account for the weight of bactericidal composition
Percentage composition is 10～60%.
Bactericidal composition of the present invention is configured to as effective ingredient with insecticides adjuvant, excipient with cycloheximide triazole with ZEN 90160
Any one dosage form allowed on pesticide；Described dosage form is water dispersible granules, wettable powder, wet seed dressing, cream, wettable
Any one in property powder, suspending agent, oil suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion and microemulsion.
Auxiliary agent known to these has emulsifying agent, wetting dispersing agent, suspending agent, defoamer, disintegrating agent, binding agent etc..
Wherein, described emulsifying agent selected from calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether,
Phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid epoxy second
Alkane addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, dodecylbenzene sodium sulfonate, dodecane
Base sulfate, TWEEN Series, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol series, Sulfonates, carboxylate, sulfate, phosphorus
One or more combinations in hydrochlorate, phosphite, lignosulfonates, phenol formaldehyde condensate, ammonium salt, quaternary etc..
The excipient of the aforementioned present invention of can be applicable to is one or more in water, solvent or filler.
Described solvent include, but are not limited to toluene, dimethylbenzene, solvent naphtha series, mixed methylnaphthalene, Oleum Terebinthinae, vegetable oil,
Methyl oleate, dichloromethane, chloroform, methanol, ethanol, isopropanol, n-butyl alcohol, Ketohexamethylene, isophorone, pyrroles
One or more of alkanone, tetrahydrofurfuryl alcohol, acetic acid dimethyl ester, 1-Phenylethanone., ethyl acetate, DMF, dimethyl sulfoxide etc..
Described filler is selected from white carbon, Kaolin, precipitated calcium carbonate, kieselguhr, corn starch, quartz sand, Pulvis Talci, sulfur
One or more of acid ammonium, sodium sulfate, sodium chloride, potassium chloride etc..
As required, the functional aids such as antifreezing agent, thickening agent, stabilizer, defoamer can also be added.
Described antifreezing agent is selected from one or more of ethylene glycol, propylene glycol, carbamide, diethylene glycol, glycerol etc..
Described thickening agent selected from xanthan gum, polyvinyl alcohol, bentonite, hydroxymethyl cellulose, aluminium-magnesium silicate one or more.
The preferred water dispersible granules of described dosage form, wettable powder, wet seed dressing, cream, wettable powder, suspending agent, oil are outstanding
Agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion or microemulsion.
Bactericidal composition containing ZEN 90160 and cycloheximide triazole of the present invention is as preparation preventing and treating resistance plant fungal disease medicine
Application.Powdery mildew, rust, Ying's rot, net blotch, downy mildew, gray mold, hemorrhagic black smallpox is prevented and treated especially as preparation
Disease, anthrax, epidemic disease and the application of damping-off medicine.
Beneficial effects of the present invention:
Bactericidal composition of the present invention is prevented and treated as preparation in the application of preparation preventing and treating refractory fungal disease medicine, especially this compound
Powdery mildew, rust, Ying's rot, net blotch, downy mildew, gray mold, anthrachose of grape, anthrax, epidemic disease and damping-off
The application of medicine all has significant effect.Above-mentioned bactericidal composition can produce higher synergistic function, and this mixture
The consumption of the independent reactive compound of amount ratio is substantially reduced, and i.e. the activity of mixture is more than the activity of independent component.
Compared with prior art beneficial effects of the present invention:
(1) compared with single dose, said composition antagonism fungal disease such as powdery mildew, rust, Ying's rot, net blotch, downy mildew
Disease, anthrax, epidemic disease, damping-off fungal disease have obvious synergistic function, overcome and delayed Drug resistance, expand anti-
Control spectrum, hence it is evident that improve prevention effect；
(2) preventing and treating recruitment, drug cost are reduced；
(3) alternative routine and the pesticide being easily generated resistance；
(4) compared with single dose, produce and use cost reduces；
(5) the suppression drug-fast generation of fungus, its effect uses apparently higher than its single dose.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but protection scope of the present invention is not limited to this.
Two kinds of reactive compounds can be processed on pesticide any one dosage form allowed, and illustrates two kinds with specific embodiment below
The preparation that effective ingredient is processed into, but the preparation that these two kinds of active component can be processed is not limited only to set forth below.
Embodiment 1
By ZEN 90160 30g, cycloheximide triazole 3g, sodium lignin sulfonate 4, sodium lauryl sulphate 2g, white carbon 2g, beautiful
Rice starch adds to 100g, and being configured to weight/mass percentage composition according to conventional formulation method is 33% water dispersible granules.
Embodiment 2
Weigh 10g ZEN 90160,2g cycloheximide triazole, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol-polyethenoxy
Ether 2g, solvent naphtha 13g, ethylene glycol 5g, add water to 100g.Being configured to weight/mass percentage composition according to conventional formulation method is
The aqueous emulsion of 12%.
Embodiment 3
Weigh 15g ZEN 90160,5g cycloheximide triazole, calcium dodecyl benzene sulfonate 6g, dodecylbenzene sodium sulfonate 3g, alkyl
Phenol polyethenoxy ether 1g, solvent naphtha 15g, propylene glycol 10g, add water to 100g.It is configured to quality according to conventional formulation method
Percentage composition is 20% microemulsion
Embodiment 4
Weigh 30g ZEN 90160,30g cycloheximide triazole, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol-polyethenoxy
Ether 1g, xanthan gum 0.1g, propylene glycol 5g, add water to 100g.Being configured to weight/mass percentage composition according to conventional formulation method is
60% suspending agent.
Embodiment 5
Weigh 10g ZEN 90160,20g cycloheximide triazole, sodium lignin sulfonate 5g, calcium dodecyl benzene sulfonate 2g, Kaolin
To 100g.Being configured to weight/mass percentage composition according to conventional formulation method is 30% wettable powder.
Embodiment 6
Weigh 5g ZEN 90160,20g cycloheximide triazole, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, molten
Agent is oily to 100g.Being configured to weight/mass percentage composition according to conventional formulation method is 25% cream.
Embodiment 7
Weigh 5g ZEN 90160,40g cycloheximide triazole, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol-polyethenoxy
Ether 1g, organobentonite 1g, propylene glycol 5g, vegetable oil complements to 100g.It is configured to quality hundred according to conventional formulation method
Dividing content is 45% oil suspending agent.
Embodiment 8
Weigh 20g ZEN 90160,60g cycloheximide triazole, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g,
White carbon 3g, fine particle calcium carbonate complement to 100g, and being configured to weight/mass percentage composition according to conventional formulation method is 80% water-dispersible grain
Agent.
Embodiment 9
Weigh 10g ZEN 90160,40g cycloheximide triazole, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g,
Kaolin complements to 100g, and being configured to weight/mass percentage composition according to conventional formulation method is 50% wet seed dressing.
Embodiment 10
Weigh 5g ZEN 90160,45g cycloheximide triazole, sodium lignin sulfonate 4g, polyoxyethylene poly-oxygen propylene aether 2g, xanthan gum
0.15g, propylene glycol 5g, aluminium-magnesium silicate 0.5g, complement to 100g with water, is configured to percent mass according to conventional formulation method
Content is 50% suspension seed-coating agent.
Embodiment 11
Weigh 10g ZEN 90160,20g cycloheximide triazole, calcium dodecyl benzene sulfonate 1g, alkylphenol polyoxyethylene phosphate ester
3g, aliphatic acid polyethenoxy ether 2g, organobentonite 1g, propylene glycol 5g, vegetable oil 10g, water complement to 100g.According to
It is 30% suspension emulsion that conventional formulation method is configured to weight/mass percentage composition.
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure the different agents EC to bacterial strain50Value, uses co-toxicity coefficient calculating side
Method, calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, and circular is as follows:
In mixture, a certain single dose (is generally selected EC as standard agent50Junior), calculate:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × A single dose toxicity index × B of proportion+B single dose in mixture of theoretical toxicity index=A single dose is mono-
Agent is proportion in mixture
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theory toxicity index × 100
When co-toxicity coefficient classification: CTC is more than 120, mixture has synergetic, is antagonism when CTC is less than 80, and CTC exists
It it is summation action between 80-120.
The table 1 ZEN 90160+cycloheximide triazole different ratio indoor biometrics result to wheat leaf rust
Result of the test illustrates, ZEN 90160 is compounding with cycloheximide triazole prevents and kill off wheat leaf rust, and proportioning all has increasing in said ratio
Effect effect, wherein ZEN 90160 is the most notable with the potentiation of proportioning 1:2 of cycloheximide triazole.
The table 2 ZEN 90160+cycloheximide triazole different ratio indoor biometrics result to powdery mildew of cucumber
Table 2 result illustrates, ZEN 90160 and cycloheximide triazole use above-mentioned compounding to have preferable Synergistic work to powdery mildew of cucumber
With, the when that wherein ZEN 90160 being 1:2 with the proportioning of cycloheximide triazole, potentiation is the most notable.
Field control effectiveness test:
The present invention has carried out the field medicine effect test of reality, and field medicine effect test is finally to evaluate under the influence of the integrated environment of field
Whether Pesticidal composition has the important means of using value.Therefore, the pesticide prepared by embodiment on the basis of indoor biometrics mixes
Preparaton has carried out preventing and treating wheat leaf rust and the field medicine effect test of powdery mildew of cucumber.
Test middle ZEN 90160 (A) and cycloheximide triazole (B) different ratio according to raw test, prepare ZEN 90160 different with cycloheximide triazole
The preparation of ratio carries out field control effectiveness test, contrast ZEN 90160 (A) and cycloheximide triazole (B) different ratio to wheat leaf rust with
The preventive effect of powdery mildew of cucumber.Testing each plot area is 66.7m2, sample 7 points, 0.5 square metre every, check wheat leaf
Rust and powdery mildew of cucumber occurrence degree.In use, ZEN 90160 (A) is configured to 25% ZEN 90160 SC, azoles
Bacterium ketone (B) is configured to 80% cycloheximide triazole WP.Dosing is effective ingredient ZEN 90160 (A) and effective ingredient cycloheximide triazole
(B) quality and, comparison medicament be 25% ZEN 90160 SC and 80% cycloheximide triazole WP.
Table 3: the double different ratio field control effectiveness test to wheat leaf rust of ZEN 90160 cycloheximide triazole EC:
As shown in Table 3, the field control effectiveness test of the medicament of the present invention is used, it is known that wheat leaf rust is had preferably by medicament of the present invention
Prevention effect, prevention effect significantly better than single dose use.
Table 4: the ZEN 90160 cycloheximide triazole EC different ratio field control effectiveness test to powdery mildew of cucumber:
As shown in Table 4, the field control effectiveness test of the medicament of the present invention is used, it is known that powdery mildew of cucumber is had preferably by medicament of the present invention
Prevention effect, prevention effect significantly better than single dose use.
To sum up: shown by the result of indoor biometrics and field medicine effect test, ZEN 90160 and cycloheximide triazole compositions have substantially
Synergistic function, the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, agricultural apply in have relatively
Good using value.
Claims (6)
1. the bactericidal composition application on the germ killing drugs preparing control rust and powdery mildew, the effective ingredient that it is characterized in that described bactericidal composition is ZEN 90160 and cycloheximide triazole, and the weight ratio of ZEN 90160 and cycloheximide triazole is 5:1,3:1,1:1,1:2,1:4 or 1:8.
2. according to the application described in claim 1, it is characterised in that: it is 2～90% that both described ZEN 90160 and cycloheximide triazole account for the weight percentage of bactericidal composition.
3. according to the application described in claim 2, it is characterised in that: it is 10～80% that both described ZEN 90160 and cycloheximide triazole account for the weight percentage of bactericidal composition.
4. according to the application described in claim 3, it is characterised in that: it is 10～60% that both described ZEN 90160 and cycloheximide triazole account for the weight percentage of bactericidal composition.
5. according to the application described in claim 1, it is characterised in that: described bactericidal composition is with ZEN 90160 and cycloheximide triazole as effective ingredient and insecticides adjuvant is configured on pesticide any one dosage form of allowing.
6. according to the application described in claim 5, it is characterised in that: described dosage form is any one in water dispersible granules, wettable powder, wet seed dressing, cream, oil suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion and microemulsion.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101400260A (en) * | 2006-03-14 | 2009-04-01 | 巴斯夫欧洲公司 | Method of inducing tolerance of plants against bacterioses |
| CN101703053A (en) * | 2009-11-13 | 2010-05-12 | 陕西上格之路生物科学有限公司 | Germicide composite containing famoxadone |
| WO2013062141A1 (en) * | 2011-10-27 | 2013-05-02 | Sumitomo Chemical Company, Limited | Composition and method for controlling plant diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101400260A (en) * | 2006-03-14 | 2009-04-01 | 巴斯夫欧洲公司 | Method of inducing tolerance of plants against bacterioses |
| CN101703053A (en) * | 2009-11-13 | 2010-05-12 | 陕西上格之路生物科学有限公司 | Germicide composite containing famoxadone |
| WO2013062141A1 (en) * | 2011-10-27 | 2013-05-02 | Sumitomo Chemical Company, Limited | Composition and method for controlling plant diseases |
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Denomination of invention: Picoxystrobin and famoxadone containing bactericidal composition and application thereof Effective date of registration: 20191012 Granted publication date: 20160810 Pledgee: Jiangsu Jiangnan Rural Commercial Bank Limited by Share Ltd Pledgor: JIANGSU FENGDENG CROP SCIENCE CO., LTD. Registration number: Y2019320010015 |