CN105941427B - A kind of bactericidal composition and its application containing volution bacterium amine and zinc thiazole - Google Patents
A kind of bactericidal composition and its application containing volution bacterium amine and zinc thiazole Download PDFInfo
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- CN105941427B CN105941427B CN201610340206.8A CN201610340206A CN105941427B CN 105941427 B CN105941427 B CN 105941427B CN 201610340206 A CN201610340206 A CN 201610340206A CN 105941427 B CN105941427 B CN 105941427B
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- China
- Prior art keywords
- volution bacterium
- bacterium amine
- bactericidal composition
- zinc thiazole
- zinc
- Prior art date
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- 241000894006 Bacteria Species 0.000 title claims abstract description 86
- 150000001412 amines Chemical class 0.000 title claims abstract description 81
- FXVNBZGTAWLLNE-UHFFFAOYSA-N 1,3-thiazole;zinc Chemical compound [Zn].C1=CSC=N1 FXVNBZGTAWLLNE-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 208000031888 Mycoses Diseases 0.000 claims abstract description 11
- 230000002265 prevention Effects 0.000 claims abstract description 11
- 230000001580 bacterial effect Effects 0.000 claims abstract description 10
- 241000221785 Erysiphales Species 0.000 claims abstract description 7
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241001272684 Xanthomonas campestris pv. oryzae Species 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 241000196324 Embryophyta Species 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 239000000839 emulsion Substances 0.000 claims description 9
- 239000000375 suspending agent Substances 0.000 claims description 8
- 239000011701 zinc Substances 0.000 claims description 8
- 239000006185 dispersion Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- 239000000575 pesticide Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- RABBMOYULJIAFU-UHFFFAOYSA-N 1h-pyrrole;thiophene Chemical class C=1C=CNC=1.C=1C=CSC=1 RABBMOYULJIAFU-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 235000013339 cereals Nutrition 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 230000002045 lasting effect Effects 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 208000035143 Bacterial infection Diseases 0.000 abstract description 2
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 2
- 230000003111 delayed effect Effects 0.000 abstract description 2
- 229940084434 fungoid Drugs 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 26
- 238000000034 method Methods 0.000 description 18
- 239000003921 oil Substances 0.000 description 16
- 235000019198 oils Nutrition 0.000 description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 12
- -1 alkyl phenol Chemical compound 0.000 description 11
- 229920000056 polyoxyethylene ether Polymers 0.000 description 11
- 229940051841 polyoxyethylene ether Drugs 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 239000004530 micro-emulsion Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- 241000209094 Oryza Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- OIWIYLWZIIJNHU-UHFFFAOYSA-N 1-sulfanylpyrazole Chemical compound SN1C=CC=N1 OIWIYLWZIIJNHU-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 239000005837 Spiroxamine Substances 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 241000589652 Xanthomonas oryzae Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- VSXGXPNADZQTGQ-UHFFFAOYSA-N oxirane;phenol Chemical compound C1CO1.OC1=CC=CC=C1 VSXGXPNADZQTGQ-UHFFFAOYSA-N 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- PUYXTUJWRLOUCW-UHFFFAOYSA-N spiroxamine Chemical compound O1C(CN(CC)CCC)COC11CCC(C(C)(C)C)CC1 PUYXTUJWRLOUCW-UHFFFAOYSA-N 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
- A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
- A01N43/30—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing volution bacterium amine and zinc thiazole and its applications.The bactericidal composition is using volution bacterium amine and zinc thiazole as principle active component, and wherein the mass ratio of volution bacterium amine and zinc thiazole is 1~90：1~90.The bactericidal composition can be applied to prevention Cereal, fruit tree, vegetable disease, has higher synergistic function, overcomes and delayed the drug resistance of germ, and sterilization speed is fast, the lasting period is long, reduces application cost, and control effect is substantially better than the use of its single dose.The present invention can be used for preventing fungoid and bacterial disease on crops, it is particularly possible to which, for preventing the fungal diseases such as powdery mildew, rust, stripe disease, bacterial blight of rice, bacterial stripe, anthracnose and bacteriosis, effect is better than single dose use.
Description
Technical field：
The present invention relates to a kind of bactericidal compositions and application thereof, especially a kind of to be lived to be main with volution bacterium amine and zinc thiazole
The bactericidal composition of property ingredient and its application.
Background technology
Volution bacterium amine (Spiroxamine), chemical formula：C18H35NO2, chemical name：The tertiary fourths of N- ethyl-N- propyl -8-
Base -1,4- dioxo spiros [4.5] decane -2- methylamines.Structural formula：
Volution bacterium amine is substitutional amine-group fungicide, and sterol biosynthesis inhibitor is main to inhibit germ C-14 deoxidation methyl
Change the synthesis of enzyme.Controlling object is wheat powdery mildew and various rust, barley leaf blotch and stripe disease.Volution bacterium amine is a kind of new
The foliage fungicide of type, absorbability, is effective for white powder disease.The work fast and lasting period is long, has both protection and therapeutic effect.
Zinc thiazole (Zinc Thiazloe, Zn Thiodiazole), molecular formula：C4H4N6S4Zn, chemical name：2- ammonia
Base -5- sulfydryl -1,3,4- thiadiazoles zinc.
The structure of zinc thiazole is made of two groups.First, thiazolyl group, no inhibition on bacteria outside the plant, but
It is efficient therapeutic agent in plant, in the plant's holey catheter, bacterium is severely damaged for medicament, and cell wall is thinning
Then disintegrate, lead to the death of bacterium.Second is that zinc ion, has the function of not only antifungal but also bactericidal.Zinc ion in medicament
It is exchanged with the cation (H+, K+ etc.) on pathogen cell membrane surface, the protein coagulating on germ cell film is caused to kill disease
Bacterium；It is intracellular that part zinc ion penetrates into pathogen, is combined with certain enzymes, its activity is influenced, and leads to dysfunction, germ because
And failure is dead.Under the collective effect of two groups, kill that germ is more thorough, and control effect is more preferable, controlling object is more extensive.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with the change of pattern of farming, melon fruits and vegetables etc.
Industrial crops cultivated area gradually expands, and disease occurrence degree, generation quantity increase, and is increased in the upper difficulty of prevention；Separately
On the one hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the control effect of single dose is had a greatly reduced quality, plant
Disease control is faced with significant challenge.
Invention content：
The purpose of the present invention is provide in view of the above technical problems a kind of applied widely, at low cost, effect it is good contain spiral shell
The plant bactericidal composition of ring bacterium amine and zinc thiazole.
It is a still further object of the present invention to provide the bactericidal compositions to cause answering on fungal disease in prevention plant epiphyte
With, especially prevention powdery mildew, rust, stripe disease, bacterial blight of rice, bacterial stripe, the fungal diseases such as anthracnose,
Purposes in bacteriosis.
The purpose of the present invention is be achieved through the following technical solutions：
A kind of bactericidal composition containing volution bacterium amine and zinc thiazole, the bactericidal composition is based on volution bacterium amine and zinc thiazole
Active ingredient is wanted, the wherein mass ratio of volution bacterium amine and zinc thiazole is 1~90：1~90, wherein effective ingredient in bactericidal composition
It is present in composition with enhancing effective amount.
The mass ratio of the bactericidal composition, wherein volution bacterium amine and zinc thiazole is preferably 1~70：1~50, further
Preferably 70：1、50：1、30：1、20：1、10：1、5：1、2.5：1、1：1、1：2、1：4、1：6、1：10、1：20、1：30、1：50.
The mass ratio of the bactericidal composition, wherein volution bacterium amine and zinc thiazole is preferably 1：30.
In the compositions of the present invention, the mass percentage that both volution bacterium amine and zinc thiazole account for composition is 2~80%.
It is preferred that 10~40%.
The bactericidal composition, wherein using volution bacterium amine and zinc thiazole as principle active component and known auxiliary agent and tax
Shape agent is re-dubbed any one dosage form allowed on pesticide.These known auxiliary agents, excipients have dispersant, diffusant, defoaming
Calcium dodecyl benzene sulfonate, alkyl phenol polyoxyethylene ether, benzyl phenol polyethenoxy may be used in agent, wetting agent, disintegrant etc.
Ether, phenethyl phenol polyethenoxy ether, fatty alcohol polyoxyethylene ether and its similar products, aliphatic amine polyoxyethylene ether, aliphatic acid ring
Oxidative ethane addition product, castor oil polyoxyethylene ether, nonylphenol polyoxyethylene ether, is spat at polyoxyethylene polyoxy propylene block compound
Warm series, fatty alcohol polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite,
One or more of lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, quaternary etc. combine, and excipient includes
Cyclohexanone, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propylene glycol), deionized water.The above auxiliary agent, excipient and other
Auxiliary material can be applied alone or be used in combination.
The bactericidal composition, dosage form are missible oil, wettable powder, suspending agent, aqueous emulsion or water dispersion granule.
Application of the above-mentioned bactericidal composition on preparing prevention fungal diseases of plants drug.Especially in prevention cereal
Application in terms of class, fruit tree, vegetable crop disease.
Above-mentioned application, the fungal diseases of plants and bacteriosis are powdery mildew, rust, stripe disease, the white leaf of rice
At least one of blight, bacterial stripe, anthracnose.
Beneficial effects of the present invention：
1, the volution bacterium amine and zinc thiazole used in the present invention, the mechanism of action is different, mutual mixture not will produce it is low touch, can assist
Same synergy reduces dosage, reduces cost.
2, the present composition scope of application increase, be suitable for prevent Cereal, fruit tree, vegetables refractory fungal disease and
Bacteriosis, especially preventing powdery mildew, rust, stripe disease, bacterial blight of rice, bacterial stripe, anthracnose etc. has
Significant effect.Bactericidal composition of the present invention is to sac fungus, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease and bacterial disease
With good control effect；And pest or fungi or bacterium is inhibited to resist single formulation (volution bacterium amine and zinc thiazole are any)
The generation of pharmacological property.Bactericidal composition of the present invention can generate higher synergistic function, and the amount ratio of the mixture is independent
The dosage of reactive compound substantially reduces, i.e., the activity of mixture is more than the activity of independent component.
Beneficial effects of the present invention compared with prior art：(1) compared with single dose, the composition antagonism fungal disease is such as
The fungal diseases such as powdery mildew, rust, stripe disease, bacterial blight of rice, bacterial stripe, anthracnose have apparent synergistic work
With overcoming and delayed drug resistance, expand prevention spectrum, hence it is evident that improve control effect；(2) prevention recruitment, drug cost are reduced；
(3) alternative routine and the pesticide for being also easy to produce resistance；(4) compared with single dose, production and application cost reduces；(5) inhibit fungi,
The generation of resistance, it is with obvious effects to be used higher than its single dose.
Specific implementation mode
The invention will be further described with reference to embodiments, and the preparation method of dosage form is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Indoor biometrics experiment：
Mycelial growth rate method is used indoors, measures EC of the different agents to bacterial strain50Value, using co-toxicity coefficient calculating side
Method calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, circular is as follows：
Using a certain single dose in mixture (EC is generally selected as standard agent50Junior), it is calculated：
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
The toxicity index of the toxicity index of theoretical toxicity index=A single doses × A single doses proportion+B single doses in mixture
× B single doses proportion in mixture
The EC of survey toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=survey toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：It is antagonism when being less than 80 that mixture, which has synergetic, CTC, when CTC is more than 120, and CTC exists
It is summation action between 80-120.
According to active ingredient volution bacterium amine (A)：Zinc thiazole (B) quality proportioning is：70：1、50：1、30：1、20：1、10：1、
5：1、2.5：1、1：1、1：2、1：4、1：6、1：10、1：20、1：30、1：50 are tested, and measure it to paddy bacterial streak
Germ (Xanthomonas oryzae Swing et al.pv.oryzlcola (Fang et al) Swing et al.'s) is total to
Malicious coefficient.
Table 1：Indoor biometrics result of the volution bacterium amine+zinc thiazole different ratio to bacterial leaf streak of rice
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 25% volution bacterium amine EC | Y=4.176+1.258X | 4.521 | - |
| 20% zinc thiazole SC | Y=2.319+3.263X | 6.632 | - |
| A:B=70:1 | Y=1.412+5.020X | 5.186 | 87.56 |
| A:B=50:1 | Y=3.014+3.203X | 4.170 | 109.09 |
| A:B=30:1 | Y=4.137+1.524X | 3.681 | 124.09 |
| A:B=20:1 | Y=2.769+3.632X | 4.115 | 111.55 |
| A:B=10:1 | Y=3.697+2.058X | 4.298 | 108.32 |
| A:B=5:1 | Y=2.512+3.629X | 4.848 | 98.47 |
| A:B=2.5:1 | Y=3.256+2.560X | 4.800 | 103.61 |
| A:B=1:1 | Y=3.225+2.322X | 5.816 | 92.44 |
| A:B=1:2 | Y=4.303+0.855X | 6.531 | 87.86 |
| A:B=1:4 | Y=2.237+3.633X | 5.760 | 105.30 |
| A:B=1:6 | Y=2.567+2.785X | 7.473 | 83.19 |
| A:B=1:10 | Y=2.252+3.236X | 7.067 | 90.02 |
| A:B=1:20 | Y=3.801+1.524X | 6.117 | 106.06 |
| A:B=1:30 | Y=2.917+2.965X | 5.041 | 129.60 |
| A:B=1:50 | Y=2.716+2.877X | 6.226 | 105.55 |
Field control effectiveness test：
The pesticidal preparations prevention bacterial leaf streak of rice experiment made from above-described embodiment.
1, test process：This test medicine dosage sets three concentration for the treatment of, comparison medicine respectively according to the difference of each ingredient
Agent is pesticide single dose 25% volution bacterium amine EC and 20% zinc thiazole SC and blank clean water experiment respectively.
2, each plot area of test method is 66.7m2, it is repeated 3 times；Investigation drug effect side after investigating and prevent before dispenser
Method is：5 points of grab sample in test process area carry out severity Scaling according to national field trial relevant criterion, calculate preventive effect.
Test result is shown in Table 2：
2 field test effect of table
By indoor biometrics and field efficacy, the result shows that, volution bacterium amine has with thiazole Zn composition significantly cooperates with increasing
Effect acts on, and the control effect of composition is excellent, and control effect is better than single dose kind, has application value in agricultural is applied.
Two kinds of reactive compounds can be processed into any one dosage form of permission, illustrate two kinds below with specific embodiment
The preparation that active ingredient is processed into, but the preparation that can process of the two kinds of active components be not limited only to it is set forth below.
Embodiment 1：15% volution bacterium amine zinc thiazole wettable powder (1:2)
By volution bacterium amine 5g, zinc thiazole 10g, detergent LS (to methoxyl group aliphatic acid amido benzene sulfonic acid sodium salt) 2g, diffusant
NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin add to 100g mixtures carry out air-flow crushing, be made effectively at
It is 15% volution bacterium amine zinc thiazole wettable powder to divide mass percent.
Embodiment 2：15% volution bacterium amine zinc thiazole wettable powder (1:4)
By volution bacterium amine 3g, zinc thiazole 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin
It adds to 100g mixtures and carries out air-flow crushing, it is 15% volution bacterium amine zinc thiazole wettable that active ingredient mass percent, which is made,
Pulvis.
Embodiment 3：14% volution bacterium amine zinc thiazole wettable powder (1:6)
By volution bacterium amine 2g, zinc thiazole 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin
It adds to 100g mixtures and carries out air-flow crushing, it is 14% volution bacterium amine zinc thiazole wettable that active ingredient mass percent, which is made,
Pulvis.
Embodiment 4：20% volution bacterium amine thiazole zincium suspension agent (1:1)
10g volution bacterium amines, 10g zinc thiazoles, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate 4g are weighed, it is yellow
Virgin rubber 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g with water, under the action of sand mill
It is 20% volution bacterium amine thiazole zincium suspension agent that effective ingredient percent, which is made,.
Embodiment 5：55% volution bacterium amine zinc thiazole aqueous emulsion (1:10)
Weigh 5g volution bacterium amines, 50g zinc thiazoles, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol
Polyoxyethylene ether 1g, solvent naphtha 13g, adds water to 100g.The method that the above raw material routinely prepares aqueous emulsion is put into mixing kettle
High speed mixes, and it is 55% volution bacterium amine zinc thiazole aqueous emulsion that effective ingredient percent, which is made,.
Embodiment 6：42% volution bacterium amine zinc thiazole missible oil (1:20)
Weigh 2g volution bacterium amines, 40g zinc thiazoles, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent
Oil is to 100g.The above raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil, effective composition quality percentage is made
Than for 42% volution bacterium amine zinc thiazole missible oil.
Embodiment 7：70% volution bacterium amine zinc thiazole missible oil (2.5:1)
Weigh 50g volution bacterium amines, 20g zinc thiazoles, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor
Sesame oil polyoxyethylene ether 2g, solvent naphtha to 100g.The above raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil,
It is 70% volution bacterium amine zinc thiazole missible oil that effective ingredient percent, which is made,.
Embodiment 8：18% volution bacterium amine zinc thiazole water dispersion granule (5：1)
Weigh 15g volution bacterium amines, 3g zinc thiazoles, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, poly- second
Enol 5g, borax 2g, diatomite 28g complement to 100g, and the above raw material is formed with effect into sub-prime by water dispersible granular agent method
Amount percentage is 17% volution bacterium amine zinc thiazole water dispersion granule.
Embodiment 9：11% volution bacterium amine zinc thiazole missible oil (10:1)
Weigh 10g volution bacterium amines, 1g zinc thiazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent
Oil is to 100g.The above raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil, effective composition quality percentage is made
Than for 11% volution bacterium amine zinc thiazole missible oil.
Embodiment 10：31.5% volution bacterium amine zinc thiazole microemulsion (20:1)
Weigh 30g volution bacterium amines, 1.5g zinc thiazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphoric acid
Ester 3g, agriculture breast 33#2g, alkyl phenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.The above raw material is routinely prepared micro-
It is mixed in the method input mixing kettle of emulsion, it is 32% volution bacterium amine zinc thiazole micro emulsion that effective ingredient percent, which is made,
Agent.
Embodiment 11：31% volution bacterium amine zinc thiazole missible oil (30:1)
Weigh 30g volution bacterium amines, 1g zinc thiazoles, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent
Oil is to 100g.The above raw material is routinely prepared and is mixed in the method input mixing kettle of missible oil, effective composition quality percentage is made
Than for 31% volution bacterium amine zinc thiazole missible oil.
Embodiment 12：51% volution bacterium amine thiazole zincium suspension agent (50:1)
Weigh 50g volution bacterium amines, 1g zinc thiazoles, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate 4g, xanthan
Glue 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g with water, in sand mill under the action of system
It is 51% volution bacterium amine thiazole zincium suspension agent at active ingredient mass percent.
Embodiment 13：32% volution bacterium amine zinc thiazole microemulsion (1:15)
Weigh 2g volution bacterium amines, 30g zinc thiazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate
3g, agriculture breast 33#2g, alkyl phenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.The above raw material is routinely prepared into micro emulsion
It is mixed in the method input mixing kettle of agent, it is 32% volution bacterium amine zinc thiazole microemulsion that effective ingredient percent, which is made,.
Embodiment 14：6% volution bacterium amine zinc thiazole aqueous emulsion (1:5)
It is poly- to weigh 1g volution bacterium amines, 5g zinc thiazoles, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol
Ethylene oxide ether 1g, solvent naphtha 13g add water to 100g.In the method input mixing kettle that the above raw material is routinely prepared to aqueous emulsion
Mixed at high speed, it is 6% volution bacterium amine zinc thiazole aqueous emulsion that effective ingredient percent, which is made,.
Embodiment 15：62% volution bacterium amine zinc thiazole microemulsion (1:30)
Weigh 2g volution bacterium amines, 60g zinc thiazoles, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate
3g, agriculture breast 33#2g, alkyl phenol polyoxyethylene ether 1g, isopropanol 10g add water to 100g.The above raw material is routinely prepared into micro emulsion
It is mixed in the method input mixing kettle of agent, it is 62% volution bacterium amine zinc thiazole microemulsion that effective ingredient percent, which is made,.
Embodiment 16：51% volution bacterium amine thiazole zincium suspension agent (1:50)
Weigh 1g volution bacterium amines, 50g zinc thiazoles, lignin 2g, polyoxyethylene poly-oxygen propylene aether and its sulfate 4g, xanthan
Glue 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g complement to 100g with water, in sand mill under the action of system
It is 51% volution bacterium amine thiazole zincium suspension agent at active ingredient mass percent.
Embodiment 17：7% volution bacterium amine zinc thiazole water dispersion granule (1：2.5)
Weigh 2g volution bacterium amines, 5g zinc thiazoles, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyethylene
Alcohol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, by the above raw material by water dispersible granular agent method be formed with effect at
It is 7% volution bacterium amine zinc thiazole water dispersion granule to divide mass percent.
Claims (7)
1. a kind of bactericidal composition containing volution bacterium amine and zinc thiazole, it is characterised in that the bactericidal composition is with volution bacterium amine and thiophene
Azoles zinc is principle active component, and wherein the mass ratio of volution bacterium amine and zinc thiazole is 1：30 or 30：1.
2. bactericidal composition according to claim 1, it is characterised in that both described volution bacterium amine and zinc thiazole account for group
The mass percentage for closing object is 2-80%.
3. bactericidal composition according to claim 2, it is characterised in that both described volution bacterium amine and zinc thiazole account for group
The mass percentage for closing object is 10-40%.
4. bactericidal composition according to claim 1, it is characterised in that with volution bacterium amine and zinc thiazole be it is main effectively at
Divide and insecticides adjuvant is configured to any one dosage form allowed on pesticide.
5. bactericidal composition according to claim 4, it is characterised in that the dosage form be missible oil, suspending agent, aqueous emulsion,
Wettable powder or water dispersion granule.
6. application of the bactericidal composition described in claim 1 on preparation prevention fungal diseases of plants, bacteriosis drug.
7. application according to claim 6, it is characterised in that the fungal diseases of plants and bacteriosis be powdery mildew,
At least one of rust, stripe disease, bacterial blight of rice, bacterial stripe, anthracnose.
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|---|---|---|---|---|
| US4851405A (en) * | 1987-03-07 | 1989-07-25 | Bayer Aktiengesellschaft | Aminomethyl heterocyclic compounds |
| CN1308070A (en) * | 2000-12-15 | 2001-08-15 | 浙江新农化工有限公司 | Anilidothiobiazole metal complex and its preparation and use |
| CN101194611A (en) * | 2007-06-08 | 2008-06-11 | 浙江新农化工股份有限公司 | Zinc thiazole suspension and preparation method thereof |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
| CN101953346A (en) * | 2010-09-15 | 2011-01-26 | 浙江新农化工股份有限公司 | Zinc thiazole-containing bactericidal composition |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851405A (en) * | 1987-03-07 | 1989-07-25 | Bayer Aktiengesellschaft | Aminomethyl heterocyclic compounds |
| CN1308070A (en) * | 2000-12-15 | 2001-08-15 | 浙江新农化工有限公司 | Anilidothiobiazole metal complex and its preparation and use |
| CN101194611A (en) * | 2007-06-08 | 2008-06-11 | 浙江新农化工股份有限公司 | Zinc thiazole suspension and preparation method thereof |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
| CN101953346A (en) * | 2010-09-15 | 2011-01-26 | 浙江新农化工股份有限公司 | Zinc thiazole-containing bactericidal composition |
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