CN104430389A - Bactericidal composition comprising famoxadone and boscalid and application thereof - Google Patents
Bactericidal composition comprising famoxadone and boscalid and application thereof Download PDFInfo
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- CN104430389A CN104430389A CN201410628854.4A CN201410628854A CN104430389A CN 104430389 A CN104430389 A CN 104430389A CN 201410628854 A CN201410628854 A CN 201410628854A CN 104430389 A CN104430389 A CN 104430389A
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- Prior art keywords
- boscalid
- famoxadone
- bactericidal composition
- han
- application
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition comprising famoxadone and boscalid and application thereof. According to the bactericidal composition, famoxadone and boscalid are taken as main active ingredients, and a weight ratio of famoxadone to boscalid is (1-90):(1-90). The bactericidal composition can be applied to control of diseases of cereals, fruit trees and vegetables. The bactericidal composition has a good synergistic effect, the drug resistance of pathogenic bacteria is overcome and delayed, the bactericidal speed is high, the lasting period is long, the application cost is reduced, and the control effect of the bactericidal composition is obviously superior to that of a single dosage. The bactericidal composition disclosed by the invention can be used for controlling fungal diseases on crops and can be particularly used for controlling powdery mildew, rust disease, gray mold, black spot, brown spot, black shank and rice blast. The effect of the bactericidal composition is better than that of a single dosage.
Description
Technical field
The present invention relates to a kind of bactericidal composition and uses thereof, especially Yi Zhong Yi famoxadone and Boscalid be main active bactericidal composition and application thereof.
Background technology
Famoxadone (Famoxadone), chemical name: 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1,3-azoles quinoline-2,4-diketone, molecular formula: C
22h
18n
2o
4, chemical structural formula is as follows:
Famoxadone Shu oxazole series bactericidal agent, has protection, treats, roots out, permeates, systemic activity.Mechanism of action is inhibitor of energy, and namely Mitochondrial electron transmission suppresses system.For wheat, barley, pea, beet, rape, tomato, capsicum, melon, potato.Prevent and treat the important disease in Ascomycetes, Basidiomycetes, Oomycete, as powdery mildew, downy mildew, net blotch, rust, glume blight, late blight etc., and can be composite with other protective fungicides.Yin Er, famoxadone is widely used a kind of bactericide.
Boscalid (Boscalid), the chloro-N-of chemical name: 2-(4-chlordiphenyl-2-base) nicotinanilide, molecular formula: C
18h
12cl
2n
2o, chemical structural formula is as follows:
Boscalid belongs to respiration inhibition series bactericidal agent; fungicidal spectrum is wider; the mechanism of action is shifted in plant by blade face infiltration; suppress mitochondrial succinate acid esters dehydrase; hinder tricarbonic acid cycle, make amino acid, sugar lacks, energy reduces, the division of interference cell and growth; there is neural activity to disease, there is protection and therapeutic action.Suppress spore germination, the extension of bacterium pipe, mycelial growth and spore mother cell to form the Main Stage of conk and breeding, bactericidal action is directly caused by parent active agent, does not have corresponding metabolic activity.Almost there is activity to all types of fungal disease, to preventing and treating, powdery mildew, gray mold, stalk break and various rots etc. are very effective, and also effective to the resistance bacterium of other medicaments, be mainly used in the control comprising the diseases such as rape, grape, fruit tree, vegetables and field crop.
At present, along with the change of pattern of farming, disease occurrence degree, the generation quantity of melon and fruit, vegetables, cereal crop all increase, and are are objectively preventing and treating difficulty increasing; On the other hand, SM, under the medicament selection pressure continued, cause the resistance of pathogen to rise year by year, the control efficiency of single dose is had a greatly reduced quality; 3rd, the speed to introduce of current new varieties of pesticides obviously declines, and lacks new action target medicament; 4th, strict gradually due to environmental requirement, portioned product is limited to use, and causes medication selectivity to become less.In a word, how effective control plant disease is the important topic that vast plant protection work person faces.
Summary of the invention
The object of the invention is for above-mentioned technical problem provide a kind of applied widely, cost is low, the plant bactericidal composition of effective Han famoxadone and Boscalid.
A further object of the invention is to provide this bactericidal composition and causes application on fungal disease at control plant epiphyte.
The object of the invention is to be realized by following measures:
A bactericidal composition for Han famoxadone and Boscalid, the active ingredient Wei famoxadone of this bactericidal composition and Boscalid, wherein the weight ratio of ， famoxadone and Boscalid is 1 ~ 90:1 ~ 90; The weight ratio of You Xuan famoxadone and Boscalid is 2 ~ 70:1 ~ 60; The weight ratio of Jin mono-step You Xuan famoxadone and Boscalid is 2 ~ 40:1 ~ 50; The weight ratio of most You Xuan famoxadone and Boscalid is 10:1 ~ 1:8.
Bactericidal composition Zhong famoxadone of the present invention and the weight percentage of Boscalid in described bactericidal composition are 2 ~ 90%; You Xuan famoxadone and the weight percentage of Boscalid in described bactericidal composition are 10 ~ 70%; Most You Xuan famoxadone and the weight percentage of Boscalid in described bactericidal composition are 15 ~ 50%.
Bactericidal composition Yi famoxadone of the present invention and Boscalid are mixed with any one formulation that agricultural chemicals allows for active ingredient and insecticides adjuvant, excipients; Described formulation is any one in water dispersible granules, wetting powder, wet seed dressing, missible oil, wetting powder, suspending agent, oil suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion and microemulsion.
These known auxiliary agents have emulsifier, wetting dispersing agent, suspending agent, defoamer, disintegrant, binding agent etc.
Wherein, described emulsifier is selected from calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, the rare block compound of polyoxyethylene polyoxy third, castor oil polyoxyethylene ether, neopelex, lauryl sulfate, TWEEN Series, fatty alcohol-polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulphate, phosphate, phosphite, lignosulfonates, phenol formaldehyde condensate, ammonium salt, one or more combinations in quaternary etc.
It is aforementioned that to can be applicable to excipient of the present invention be one or more in water, solvent or filler.
Described solvent includes, but are not limited to one or more of toluene, dimethylbenzene, solvent naphtha series, mixed methylnaphthalene, turpentine oil, vegetable oil, methyl oleate, carrene, chloroform, methyl alcohol, ethanol, isopropyl alcohol, n-butanol, cyclohexanone, isophorone, pyrrolidones, tetrahydrofurfuryl alcohol, acetic acid dimethyl ester, acetophenone, ethyl acetate, DMF, dimethyl sulfoxide (DMSO) etc.
Described filler is selected from one or more of white carbon, kaolin, precipitated calcium carbonate, diatomite, corn starch, quartz sand, talcum powder, ammonium sulfate, sodium sulphate, sodium chloride, potassium chloride etc.
As required, also the functional aids such as antifreezing agent, thickener, stabilizing agent, defoamer can be added.
Described antifreezing agent is selected from one or more of ethylene glycol, propane diols, urea, diethylene glycol (DEG), glycerine etc.
Described thickener be selected from xanthans, polyvinyl alcohol, bentonite, CMC, aluminium-magnesium silicate one or more.
Described formulation preferred water dispersible granule, wetting powder, wet seed dressing, missible oil, wetting powder, suspending agent, oil suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion or microemulsion.
The application of bactericidal composition of the present invention in the medicine of preparation control resistance plant fungal disease, the application preferably in preparation control Cereal, fruit tree, vegetable crop powdery mildew, rust, gray mold, black spot, brown spot, balck shank or rice blast medicine.
The application of bactericide of the present invention on control resistance plant fungal disease, the application preferably in control Cereal, fruit tree, vegetable crop powdery mildew, rust, gray mold, black spot, brown spot, balck shank or rice blast.
Beneficial effect of the present invention:
The present composition scope of application increases, and is applicable to the disease of preventing and treating Cereal, fruit tree, vegetables, particularly prevents and treats the fungal diseases such as powdery mildew, rust, gray mold, black spot, brown spot, balck shank, rice blast.Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; And Antifungi to unitary agent (famoxadone and Boscalid arbitrary) drug-fast generation.
The application of bactericidal composition of the present invention on preparation control refractory fungal, especially all has significant effect in the application preventing and treating the fungal diseases such as powdery mildew, rust, gray mold, black spot, brown spot, balck shank, rice blast.Famoxadone and the composite energy of Boscalid produce higher synergistic function, and the consumption of the independent reactive compound of the amount ratio of this mixture reduces greatly, and namely the activity of mixture is greater than the activity of independent component.
Compared with prior art beneficial effect of the present invention: (1) is compared with single dose, said composition antagonism fungal disease such as the fungal diseases such as powdery mildew, rust, gray mold, black spot, brown spot, balck shank, rice blast have obvious synergistic function, overcome and delayed pesticide resistance, expanding prevention is composed, and significantly improves control efficiency; (2) control recruitment, drug cost is reduced; (3) alternative routine and the easy agricultural chemicals producing resistance; (4) compared with single dose, produce and use cost reduction; (5) the drug-fast generation of Antifungi, its successful uses higher than its single dose.
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method, and " % " of the present invention is mass percent.
Two kinds of reactive compounds can be processed into any one formulation of permission, with specific embodiment, the preparation that two kinds of active ingredients are processed into are described below, but the preparation that these two kinds of active components can be processed be not limited only to following listed by.
Embodiment 1:
Take 20g famoxadone, 2g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 22% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 2:
Take 25g famoxadone, 5g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 30% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 3:
Take 30g famoxadone, 10g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 40% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 4:
Take 25g famoxadone, 25g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 50% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 5:
Take 5g famoxadone, 10g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 15% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 6:
Take 5g famoxadone, 20g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 25% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 7:
Take 5g famoxadone, 40g Boscalid, triphen ethyl phenol polyoxyethylene ether phosphate 3g, alkylphenol polyoxyethylene 1g, xanthans 0.1g, propane diols 5g, add water to 100g.It is 45% suspending agent that formulation method is conveniently mixed with mass percentage.
Embodiment 8:
Take 40g famoxadone, 10g Boscalid, sodium lignin sulfonate 5g, calcium dodecyl benzene sulfonate 2g, kaolin are to 100g.It is 50% wetting powder that formulation method is conveniently mixed with mass percentage.
Embodiment 9:
Take 5g famoxadone, 10g Boscalid, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.It is 15% missible oil that formulation method is conveniently mixed with mass percentage.
Embodiment 10:
Take 40g famoxadone, 30g Boscalid, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, kaolin complements to 100g, and it is 70% wet seed dressing that formulation method is conveniently mixed with mass percentage.
Embodiment 11:
Take 5g famoxadone, 15g Boscalid, sodium lignin sulfonate 4g, polyoxyethylene poly-oxygen propylene aether 2g, xanthans 0.15g, propane diols 5g, aluminium-magnesium silicate 0.5g, complement to 100g with water, it is 20% suspension seed-coating agent that formulation method is conveniently mixed with mass percentage.
Yong famoxadone and the former medicine of Boscalid carry out biological activity determination.
In indoor employing mycelial growth rate method, measure different agents to the EC of bacterial strain
50value, adopt co-toxicity coefficient computational methods, calculate the co-toxicity coefficient (CTC) of mixture, determine the building performance of mixture, circular is as follows:
With single dose a certain in mixture for standard agent (selects EC usually
50junior), calculate:
Single dose toxicity index=standard agent EC
50/ certain single dose EC
50× 100
Toxicity index × B single dose proportion in mixture of toxicity index × A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
When co-toxicity coefficient classification: CTC is greater than 120, mixture has synergetic, and be antagonism when CTC is less than 80, CTC is summation action between 80-120.
Table 1 cycloheximide triazole+Boscalid different ratio is to the indoor biometrics result of rice blast
| Medicament | EC50(mg/L) | Actual measurement toxicity index | Theoretical coefficient | Co-toxicity coefficient |
| Famoxadone (A) | 32.68 | 100 | —— | |
| Boscalid (B) | 8.21 | 398.05 | —— | |
| A:B＝10:1 | 18.31 | 178.48 | 127.1 | 140 |
| A:B＝5:1 | 15.34 | 213.04 | 149.7 | 142 |
| A:B＝3:1 | 13.78 | 237.16 | 174.5 | 136 |
| A:B＝1:1 | 8.69 | 376.06 | 249 | 151 |
| A:B＝1:2 | 8.08 | 404.46 | 298.7 | 135 |
| A:B＝1:4 | 7.2 | 453.89 | 338.4 | 134 |
| A:B＝1:8 | 6.43 | 508.24 | 364.9 | 139 |
Result of the test illustrates, famoxadone and the composite control rice blast of Boscalid, in said ratio, all have synergistic effect, wherein the synergistic effect of proportioning 1:1 is the most remarkable.
Table 2 cycloheximide triazole+Boscalid different ratio is to the indoor biometrics result of powdery mildew of cucumber
| Medicament | EC50(mg/L) | Actual measurement toxicity index | Theoretical coefficient | Co-toxicity coefficient |
| Famoxadone (A) | 31.24 | 100 | - | |
| Boscalid (B) | 8.33 | 375.03 | - | |
| A:B＝10:1 | 18.52 | 168.68 | 125 | 135 |
| A:B＝5:1 | 16.34 | 191.19 | 145.8 | 131 |
| A:B＝3:1 | 14.18 | 220.31 | 168.8 | 131 |
| A:B＝1:1 | 8.71 | 358.67 | 237.5 | 151 |
| A:B＝1:2 | 8.31 | 375.93 | 283.4 | 133 |
| A:B＝1:4 | 7.22 | 432.69 | 320 | 135 |
| A:B＝1:8 | 6.63 | 471.19 | 344.5 | 137 |
， famoxadone is described result of the test and Boscalid is composite prevents and treats powdery mildew of cucumber, and in said ratio, all have synergistic effect, wherein the synergistic effect of proportioning 1:1 is the most remarkable.
Field control effectiveness test:
Indoor biometrics shows good Pesticidal composition, actual field medicine effect test must be carried out, field medicine effect test is the important means that whether final evaluation Pesticidal composition has using value under the impact of field integrated environment, therefore, the field medicine effect test preventing and treating rice blast and powdery mildew of cucumber has been carried out with the pesticide mixed preparation that embodiment obtains in the basis of indoor biometrics.
Obtain preparation according to raw test Yan Zhong famoxadone and Boscalid different ratio and carry out field control effectiveness test, contrast agents is 25% famoxadone EC and 20% Boscalid SC and clear water respectively, and each plot area is 66.7m
2, repeat 3 times; Inspection drug effect method before dispenser after Investigation and Prevention is: in test treatment region, adopt accidental sampling, sample 7 points, 0.5 square metre often, check rice sheath blight disease and powdery mildew of cucumber occurrence degree.
Table 3: famoxadone+Boscalid different ratio is to the field control effectiveness test of rice blast
Table 4: famoxadone+Boscalid different ratio is to the field control effectiveness test of powdery mildew of cucumber
Known by testing above, the present invention has good synergistic effect to plant disease.
Claims (10)
1. contain a bactericidal composition for famoxadone and Boscalid, it is characterized in that: the active ingredient of this bactericidal composition is famoxadone and Boscalid, wherein, the weight ratio of famoxadone and Boscalid is 1 ~ 90:1 ~ 90.
2. the bactericidal composition of Han famoxadone according to claim 1 and Boscalid, is characterized in that the weight ratio of: famoxadone and Boscalid is 2 ~ 70:1 ~ 60.
3. the bactericidal composition of Han famoxadone according to claim 2 and Boscalid, is characterized in that the weight ratio of Suo Shu famoxadone and Boscalid is 2 ~ 40:1 ~ 50.
4. the bactericidal composition of Han famoxadone according to claim 3 and Boscalid, is characterized in that the weight ratio of Suo Shu famoxadone and Boscalid is 10:1 ~ 1:8.
5. the bactericidal composition of Han famoxadone and Boscalid according to any one of claim 1-4, Qi feature Shi famoxadone and the weight percentage of Boscalid in described bactericidal composition are 2 ~ 90%.
6. the bactericidal composition of Han famoxadone according to claim 5 and Boscalid, Qi feature Shi famoxadone and the weight percentage of Boscalid in described bactericidal composition are 10 ~ 70%, You Xuan famoxadone and the weight percentage of Boscalid in described bactericidal composition is 15 ~ 50%.
7. the bactericidal composition of Han famoxadone and Boscalid according to any one of claim 1-4, is characterized in that: this bactericidal composition Yi famoxadone and Boscalid are mixed with any one formulation that agricultural chemicals allows for active ingredient and insecticides adjuvant, excipients.
8. the bactericidal composition containing famoxadone and Boscalid according to claim 7, it is characterized in that described formulation is water dispersible granules, wetting powder, wet in seed dressing, missible oil, wetting powder, suspending agent, oil suspending agent, suspension emulsion, suspension seed-coating agent, aqueous emulsion and microemulsion any one.
9. the application of bactericidal composition according to claim 1 in the medicine of preparation control resistance plant fungal disease.
10. application according to claim 9, is characterized in that: the application of bactericidal composition according to claim 1 in preparation control Cereal, fruit tree, vegetable crop powdery mildew, rust, gray mold, black spot, brown spot, balck shank or rice blast medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104488887A (en) * | 2014-12-03 | 2015-04-08 | 广东中迅农科股份有限公司 | Bactericidal composition containing famoxadone and boscalid |
| CN106135229A (en) * | 2015-04-13 | 2016-11-23 | 南京华洲药业有限公司 | A kind of containing Boscalid and the bactericidal composition of cycloheximide triazole and application |
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| CN1282215A (en) * | 1997-12-18 | 2001-01-31 | 巴斯福股份公司 | Fungicide mixtures based on carboxamides and pyridine derivatives |
| CN101808521A (en) * | 2007-09-26 | 2010-08-18 | 巴斯夫欧洲公司 | ternary fungicidal compositions comprising boscalid and chlorothalonil |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4957933A (en) * | 1989-04-21 | 1990-09-18 | E. I. Du Pont De Nemours And Company | Fungicidal oxazolidinones |
| CN1282215A (en) * | 1997-12-18 | 2001-01-31 | 巴斯福股份公司 | Fungicide mixtures based on carboxamides and pyridine derivatives |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104488887A (en) * | 2014-12-03 | 2015-04-08 | 广东中迅农科股份有限公司 | Bactericidal composition containing famoxadone and boscalid |
| CN106135229A (en) * | 2015-04-13 | 2016-11-23 | 南京华洲药业有限公司 | A kind of containing Boscalid and the bactericidal composition of cycloheximide triazole and application |
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